基于脑电的磁刺激穴位复杂脑功能网络研究
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摘要
穴位是体表刺激到体内神经系统调控的切入点，磁刺激技术因具有诸多不可比拟的优势而有望成为一种穴位新疗法，但是目前磁刺激穴位的疗效缺乏统一且合理的评定方法，还需进行深入探究。脑连接组学研究的逐步深入和复杂网络理论的飞速发展为磁刺激穴位的研究开辟了新途径。
本文利用复杂网络分析方法，以内关穴为例开展了基于高时间分辨率脑电的磁刺激穴位脑功能网络的构建与分析研究，旨在从整体性角度探索磁刺激穴位对大脑功能连接的影响，为穴位磁刺激的作用效应评价提供新手段，尤其为精神类等疾病的临床康复治疗效果评价提供新思路。本文主要研究内容如下：
1、设计并开展了不同频率磁刺激穴位和非穴位不同阶段的脑电采集实验，采用互相关和互信息方法对不同状态下高分辨率的脑电信号进行了多通道关联特性分析，结果发现3Hz磁刺激内关穴时脑功能连接增强的趋势较为明显。
2、基于磁刺激穴位的多通道脑电信号关联特性矩阵构建了无权和加权脑功能网络，并对网络特征量进行了深入分析，结果发现3Hz磁刺激内关穴时脑功能网络连接边、平均度、平均聚类系数和全局效率显著增加，平均路径长度显著降低。磁刺激非穴位时脑功能网络特征量的变化明显小于穴位刺激引起的变化。
3、对磁刺激穴位的无权和加权脑功能网络进行了中心度和中心化程度分析，结果发现3Hz磁刺激内关穴时额叶、中央区以及顶叶大部分节点的度中心度和紧密中心度明显升高，顶叶和中央区部分节点的介数中心度明显减小。磁刺激非穴位时脑功能网络中心度的变化明显小于穴位刺激引起的变化。
4、对磁刺激穴位的脑功能网络进行了“小世界”属性评价，结果发现所有被试不同刺激阶段的脑功能网络均具有“小世界”属性，3Hz磁刺激内关穴时脑功能网络的“小世界”属性显著增强。磁刺激非穴位时脑功能网络“小世界”属性的变化小于穴位刺激引起的变化。
Acupoint is the breakthrough point between body surface stimulation and internalnervous system regulation. Magnetic stimulation technique is expected to become a newacupoint therapy because of many incomparable advantages, but the curative effect ofmagnetic stimulation on acupoint is lack of unified and rational evaluation methods, whichneeds to be further explored. The rapid development of human connectome and complexnetwork theory provides a new way to the research of magnetic stimulation efficacy onacupuncture point.
The brain functional network construction and analysis of magnetic stimulation onNeigaun (PC6) is carried out based on the high temporal resolution electroencephalogramusing complex network method. It aims at exploring the influence of magnetic stimulationon the brain functional connection from a holistic point of view, and providing new ideas tothe efficacy evaluation of acupoint magnetic stimulation especially in psychiatric diseasesrehabilitation treatment. The main contents were as follows:
1. The EEG acquisition experiments of magnetic stimulation on acupoint andnon-acupoint with different frequencies were designed and carried out. The associatedfeatures of the acquired EEG data with high resolution were analyzed usingcross-correlation and mutual information method. The results found that brain functionalconnectivity obviously enhanced under high frequency magnetic stimulation on Neiguanacupoint.
2. The unweighted and weighted brain fuctional networks were constructed based onthe multi-channel EEG associated features of magnetic stimulation on, acupoint and thenetwork characteristics were further analysed. The results found that the edges, averagedegree, average clustering coefficient and global efficiency of brain functional networksobservably increased, however, the average path length decreased under high frequencymagnetic stimulation on Neiguan acupoint. The characteristics change caused bynon-acupoint stimulation was significantly less than the acupoint stimulation.
3. The centrality and centralized degree were analysed of the unweighted andweighted brain fuctional networks. The results found that the degree centrality and closecentrality obviously increased of nodes in frontal lobe, central region, and the parietal lobe,however, the betweenness centrality decreased in the parietal lobe and central region underhigh frequency magnetic stimulation on Neiguan acupoint. The centrality change caused by non-acupoint stimulation was significantly less than the acupoint stimulation.
4. The small world properties of the brain functional networks were also evaluated inthis paper. The results found that all brain functional networks had small world propertiesin different magnetic stimulation stages of all subjects, and the small world propertiessignificantly enhanced under high frequency magnetic stimulation on Neiguan acupoint.The small world properties change caused by non-acupoint stimulation was less than theacupoint stimulation.
本文利用复杂网络分析方法，以内关穴为例开展了基于高时间分辨率脑电的磁刺激穴位脑功能网络的构建与分析研究，旨在从整体性角度探索磁刺激穴位对大脑功能连接的影响，为穴位磁刺激的作用效应评价提供新手段，尤其为精神类等疾病的临床康复治疗效果评价提供新思路。本文主要研究内容如下：
1、设计并开展了不同频率磁刺激穴位和非穴位不同阶段的脑电采集实验，采用互相关和互信息方法对不同状态下高分辨率的脑电信号进行了多通道关联特性分析，结果发现3Hz磁刺激内关穴时脑功能连接增强的趋势较为明显。
2、基于磁刺激穴位的多通道脑电信号关联特性矩阵构建了无权和加权脑功能网络，并对网络特征量进行了深入分析，结果发现3Hz磁刺激内关穴时脑功能网络连接边、平均度、平均聚类系数和全局效率显著增加，平均路径长度显著降低。磁刺激非穴位时脑功能网络特征量的变化明显小于穴位刺激引起的变化。
3、对磁刺激穴位的无权和加权脑功能网络进行了中心度和中心化程度分析，结果发现3Hz磁刺激内关穴时额叶、中央区以及顶叶大部分节点的度中心度和紧密中心度明显升高，顶叶和中央区部分节点的介数中心度明显减小。磁刺激非穴位时脑功能网络中心度的变化明显小于穴位刺激引起的变化。
4、对磁刺激穴位的脑功能网络进行了“小世界”属性评价，结果发现所有被试不同刺激阶段的脑功能网络均具有“小世界”属性，3Hz磁刺激内关穴时脑功能网络的“小世界”属性显著增强。磁刺激非穴位时脑功能网络“小世界”属性的变化小于穴位刺激引起的变化。
Acupoint is the breakthrough point between body surface stimulation and internalnervous system regulation. Magnetic stimulation technique is expected to become a newacupoint therapy because of many incomparable advantages, but the curative effect ofmagnetic stimulation on acupoint is lack of unified and rational evaluation methods, whichneeds to be further explored. The rapid development of human connectome and complexnetwork theory provides a new way to the research of magnetic stimulation efficacy onacupuncture point.
The brain functional network construction and analysis of magnetic stimulation onNeigaun (PC6) is carried out based on the high temporal resolution electroencephalogramusing complex network method. It aims at exploring the influence of magnetic stimulationon the brain functional connection from a holistic point of view, and providing new ideas tothe efficacy evaluation of acupoint magnetic stimulation especially in psychiatric diseasesrehabilitation treatment. The main contents were as follows:
1. The EEG acquisition experiments of magnetic stimulation on acupoint andnon-acupoint with different frequencies were designed and carried out. The associatedfeatures of the acquired EEG data with high resolution were analyzed usingcross-correlation and mutual information method. The results found that brain functionalconnectivity obviously enhanced under high frequency magnetic stimulation on Neiguanacupoint.
2. The unweighted and weighted brain fuctional networks were constructed based onthe multi-channel EEG associated features of magnetic stimulation on, acupoint and thenetwork characteristics were further analysed. The results found that the edges, averagedegree, average clustering coefficient and global efficiency of brain functional networksobservably increased, however, the average path length decreased under high frequencymagnetic stimulation on Neiguan acupoint. The characteristics change caused bynon-acupoint stimulation was significantly less than the acupoint stimulation.
3. The centrality and centralized degree were analysed of the unweighted andweighted brain fuctional networks. The results found that the degree centrality and closecentrality obviously increased of nodes in frontal lobe, central region, and the parietal lobe,however, the betweenness centrality decreased in the parietal lobe and central region underhigh frequency magnetic stimulation on Neiguan acupoint. The centrality change caused by non-acupoint stimulation was significantly less than the acupoint stimulation.
4. The small world properties of the brain functional networks were also evaluated inthis paper. The results found that all brain functional networks had small world propertiesin different magnetic stimulation stages of all subjects, and the small world propertiessignificantly enhanced under high frequency magnetic stimulation on Neiguan acupoint.The small world properties change caused by non-acupoint stimulation was less than theacupoint stimulation.
引文
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