基于关联规则的病毒性肺炎热郁痰瘀病机理论研究
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摘要
小儿肺炎是儿科的常见病和多发病,是我国小儿重点防治的四病之一,而病毒性肺炎约占其中的1／2。小儿病毒性肺炎是中医药治疗的优势病种,取得良好的临床疗效和大量的临床研究成果,在辨治理论上也进行了许多探讨研究,达到一定的认识深度。但是对这一疾病的中医辨证论治方法尚有待客观化和规范化。在中医药学界当今注重中医传统研究方法与循证医学相结合的形势下,有必要应用传统研究方法与现代科学技术相结合,加强对该病的客观化和规范化的研究。
数据挖掘是近20年新兴的一门交叉学科,它和数据库中的知识发现是两个等价的概念。关联规则是数据挖掘技术的最常用和较为成熟的方法之一,它描述数据库中数据项(属性、变量)之间所存在的(潜在)关系,对于突出以症状体征关联出现的中医证候学的研究具有适用性,以及通过证候学分析认识病因病机,形成病机理论。
导师汪受传教授为全国名老中医,潜心研究病毒性肺炎十五年,诊治大量本病患者,形成独立的学术思想,在理论和临床研究中探讨、应用热、郁、痰、瘀病机理论指导病毒性肺炎的辨证论治,取得良好疗效和丰硕成果。
为了对深入开展病毒性肺炎中医辨证论治的客观化和规范化研究打下良好基础,为了探讨利用现代科技手段对名老中医经验和学术思想研究、总结的新模式、新方法,在此,运用数据挖掘技术,主要运用关联规则方法,开展病毒性肺炎热郁痰瘀病机理论研究。
目的：通过理论、临床、数理研究建立病毒性肺炎病机理论。
方法：在文献研究和理论研究的基础上,运用关联规则方法,对大样本、多中心、随机分组的病毒性肺炎临床研究数据源进行挖掘,开展理论、临床、数理三结合的病毒性肺炎病机理论研究。
结果：
1、理论研究方面：通过古今文献研究发现,古代医籍中有关于肺炎病机与热、郁、痰、瘀相关的散在论述,现代也有学者提出以痰热郁闭或痰热瘀闭论治本病的观点,并有相关的临床研究报道,说明病毒性肺炎热郁痰瘀病机理论具有古代和现代专家意见的基础。
2、临床研究和数理研究方面：在临床研究的基础上,利用本病临床研究的数据源,从临床的证候学入手,进行关联规则运算,发现在发病之际,常见热邪炽盛、肺气郁阻、痰涎壅盛和血脉瘀阻(简称热、郁、痰、瘀)的病机病理。轻度患儿的热邪与正气争斗的病机改变相对较轻,而肺气郁阻与痰涎壅盛以及血脉瘀阻的病机病理已较为严重；中度患儿热邪与正气剧烈争斗、肺气郁阻和痰涎壅盛的病机病理已较为严重,而血脉瘀阻的病机病理相对较轻。重度患儿热邪炽盛、肺气郁阻与痰涎壅盛以及血脉瘀阻的病机病理均较为严重。在治疗过程中,热邪炽盛、肺气郁阻、痰涎壅盛和血脉瘀阻的病机病理均逐渐减轻。热邪炽盛的病机病理在初、中期明显,末期轻微；肺气郁阻和痰涎壅盛的病机病理在疾病全过程都较明显：血脉瘀阻的病机病理在疾病初期较为明显,在疾病中后期相当轻微或消失。在药物干预下,试验组与对照组的病机演变规律相似,但作支持度比较,大多数时间上,大多数项集(如热证候、郁证候、痰证候或热与郁关联证候、热与痰关联证候、热与郁与痰关联证候等)两组差异有显著性(P＜0.05～0.01),且试验组比对照组提前1～3天消失。说明在改善热邪炽盛、肺气郁阻、痰涎壅盛或热邪炽盛与肺气郁阻关联病机、热邪炽盛与痰涎壅盛关联病机、热邪炽盛与肺气郁阻与痰涎壅盛关联病机等方面,试验组效果优于对照组。
在疾病全过程,治疗前后都有热、郁、痰、瘀四者之间形成的2～7项的关联病机,如形成热与郁、热与痰、热与瘀、郁与痰、郁与瘀、痰与瘀、热与郁与痰、热与郁与瘀、热与痰与瘀、郁与痰与瘀、热与郁与痰与瘀等关联的病机病理,且由热致郁、致痰、致瘀,或由郁致热、致痰、致瘀,或由痰致热、致郁、致瘀,或由瘀致热、致郁、致痰的病机演变均有一定的规律性和相互作用强度的概率。其规律性和概率的变化在治疗前后有部分基本不变,而部分呈逐日下降的变化,如由郁致痰或由痰致郁的概率极高,基本上在治疗前后一致,极少发生变化。由热或痰或瘀等致郁,以及由热或郁或瘀致痰的概率极高,也基本上是治疗前后极少变化。由郁或痰或瘀致热的概率常常可见治疗后逐日下降。由瘀致热或郁或痰的概率往往大于由热或郁或痰致瘀的概率。
3.病毒性肺炎热郁痰瘀病机理论的主要内容：在病毒性肺炎中,多数由热致病,热致气郁,热炼痰蓄,气郁血瘀。同时,气机郁阻、痰涎蓄积、血脉瘀阻又是热邪不散的影响因素。热、郁、痰、瘀四者并存且相互关联,循序渐变,互为因果,环环相连,在疾病过程中极易形成热郁、热痰、热瘀、痰郁、痰瘀或热郁痰、热郁瘀、热痰瘀、痰郁瘀或热郁痰瘀互结的病机病理改变。在本病中,热邪为患是本病的始动因素,热邪与正气相争贯穿疾病的全过程,.但在药物的干预下,此病因病机有逐渐减少的变化,其他病机对此病机影响的可能性也随之降低。各种病因病机影响到肺气郁阻与痰涎壅盛病机变化的可能性很少随时间改变,肺气郁阻与痰涎壅盛病机病理在本病中甚为重要,占主导地位。痰与瘀均为有形的病理产物(尤其是后者),其影响热或郁的可能性甚于热或郁对它们的影响,在病机演变中有重要作用。
结论：
1.热、郁、痰、瘀是病毒性肺炎急性期的基本病因病机病理。通过理论、临床和数理三结合建立的病毒性肺炎热郁痰瘀病机理论,具有良好的实践基础和循证基础,对建立病毒性肺炎中医诊治理论体系和中医辨证论治客观化、规范化、标准化研究具有启迪作用。
2.运用中医传统认识论与现代研究方法(包括数据挖掘方法)相结合研究名老中医学术思想,具有提炼病机病理辨证观点和总结处方用药规律的作用,有利于传承和弘扬名老中医学术思想。以导师汪受传教授论治病毒性肺炎的主要学术思想提炼形成的热郁痰瘀病机理论,是对病毒性肺炎急性期中医基本病机病理的概括,为创新病毒性肺炎中医诊治理论体系奠定了良好基础。
3.在改善热、郁、痰、瘀及其关联病机方面,中医试验组疗效优于西药对照组。应用关联规则方法可以建立突出中医辨证论治内涵、更加符合中医特点和规律的中医临床疗效评价方法。
Pneumonia, one of four key diseases prevention in our nation, is common and frequently-occurring for children, of them viral pneumonia accounts for about 1/2. Traditional Chinese Medicine specializes in the treatment of children with viral pneumonia, have a good effect and a large number of clinical studies. Many scholars have conducted many studies with syndrome differentiation and treatment methods, and have had a certain degree of understanding. However, the methods still need objective and normalization. In the situation of Traditional Chinese Medicine Schools emphasis on Chinese traditional research methods combined with evidence-based medicine. There is necessary to deepen the study of infantile pneumonia, using traditional research methods combined with the modern science and technology, make it more objective and normalized.
Data mining is an emerging interdisciplinary in the last 20 years, which means the knowledge discovery of databases. Association rule is one of the most common and sophisticated methods in the data mining, it describes the (potential) relationship among data items in the database (attributes, variables), applies to the study on the TCM Syndrome which stress the relations between diagnostics and physical sign.
As a national well-known old TCM, my mentor Professor Wang Shouchuan has studied the viral pneumonia for 15 years, treated a large number of the patients, and formed independent academic thought. With the guide of the pathogenesis of heat-constraint-phlegm-blood stasis, he had made good effect and outcome in the treatment of viral pneumonia.
In order to lay a solid foundation for the further objective and standard research of the TCM pattern differentiation and treatment for viral pneumonia, study and summarize the experience and academic thinking of the famous veteran doctors of TCM with the modern technology, we will carry out a research of viral pneumonia concerning Heat-Constraint-Phlegm-Blood stasis Pathogenesis theory, using the data mining, mainly the Association rule.
Objective
Through the theoretical, clinical and statistical studies, establish the pathogenesis theory of viral pneumonia.
Methods
To excavate the large sample, multi-center, randomized clinical study of viral pneumonia in the data source, carry out a research of the pathogenesis theory of viral pneumonia with the theoretical, clinical and statistical studies, using association rule, on the basis of literature and theoretical studies.
Results
1. Theoretical research:
Some scattered words about the pathogenesis of pneumonia which is relative with heat, constraint, phlegm and blood stasis in the ancient medical books, by studying the ancient and modern literatures; Some modern scholars put forward treatment with phlegm-heat-constraint block or phlegm-heat-stasis block, and there are some clinical research reports about them; all this shows that the study of Heat-Depression-Phlegm-Blood stasis Pathogenesis theory has ancient and modern basis of expert advices.
2. Clinical research and mathematical research:
Using the disease data sources from clinical studies, based on clinical studies, start from the clinical Syndrome, compute association rules, it can be found that the pathogenesis of intense heat pathogen, lung qi constraint, phlegm and fluid obstruction and blood vessels stasis obstruction (the "heat, constraint, phlegm and blood stasis") often can be seen in the onset of the occasion.
The pathogenesis of overabundance of pathogenic heat is clear in the early and middle stage, slight late, while the pathogenesis of lung qi constraint and phlegm-fluid accumulation are obvious in the whole process, blood stasis obvious in the early and minor late. Pathogenesis Evolution rule of the experimental group and control group is similar in drug intervention, but more for support, most of the time, most of the itemsset (such as heat syndrome, depressive syndrome, sputum or fever syndrome associated with depression syndrome, fever syndrome associated with sputum, fever and depression associated with syndrome of phlegm, etc.) between the two groups was significant (P<0.05-0.01), and compared with the control group 1 to 3 days before disappearing. It shows that the experimental group is better than the control group in the aspects of improving the rising heat pathogen, Qi constraint, hold the spit with the rising dampness or heat evil associated with lung disease resistance machines depression, the rising heat pathogen, hold the spit dampness associated with disease pathogenesis, the rising heat pathogen and lung resistance with depression pathogenesis associated with dampness.
In the whole process of disease, heat, constraint, phlegm and blood stasis associated each other and form the 2 to 7 interrelated pathogenesis, such as the formation of hot and constraint, hot and sputum, heat and blood stasis, phlegm and depression, depression and blood stasis, phlegm and blood stasis, heat and constraint and sputum, heat and depression and blood stasis, heat and phlegm and blood stasis, phlegm and blood stasis with depression, heat and depression associated with phlegm and stasis, or heat causing constraint, causing phlegm and causing stasis, or depression causing heat, causing phlegm, resulting in stasis, or phlegm causing depression, causing heat and causing blood stasis, or stasis causing heat, causing constraint and causing phlegm. There is a probability of regularity and strength of interactions in the evolution of the pathogenesis, the changes of the regularity and probability almost stay the same before and after treatment. By thermal or induced sputum or blood, etc. Depression and depression from the heat or phlegm or blood stasis caused by high probability, it is basically little changed before and after treatment. From the phlegm or blood caused by depression or the probability of heat treatment often can be seen daily decline. Stasis caused by the heat or the probability of depression or sputum is often greater than the heat or depression or the probability of stasis caused by phlegm.
3. The main content of heat-constraint-phlegm-stasis pathogenesis theory about viral pneumonia:
In viral pneumonia, the majority of pathogens from the heat, heat induced Qi constraint, phlegm accumulation due to heat, blood stasis due to qi constraint. Meanwhile, Qi constraint, phlegm accumulation, blood stasis are the factors which make heat pathogen retention. Heat, constrain, phlegm, blood stasis and the coexistence of the four inter-related, progressive gradual, reciprocal causation, ring linked to the disease process is extremely easy in the formation of thermal depression, the pathogenesis of heat-constraint, heat-phlegm, heat-stasis, phlegm-constraint, phlegm-stasis, or heat-constraint-phlegm, heat-constraint-stasis, phlegm-constraint-stasis, or binding of heat-constraint-phlegm-stasis often can be seen in the course of this disease. In this disease, the heat pathogen infestation is the initiating factor of this disease, the struggle between heat pathogen and healthy qi throughout the whole process of the disease, but under the drug intervention, the disease has gradually decreased due to illness changes, so dose the possible influence of the other pathogenesis. The possibilities of various etiology and pathogenesis will influence the pathogenesis variation of lung qi constraint and phlegm-fluid accumulation little change over time, and they are important pathogenesis in this disease and took the domination position. Phlegm and blood stasis are also the product of physical pathology, especially the blood stasis, which influence to the heat and stasis was larger than heat and stasis to them, play an important role in the evolution of pathogenesis.
Conclusion
1. Heat, constraint, phlegm and blood stasis are the basic pathogenesis of the acute viral pneumonia. This pathogenesis theory of viral pneumonia established through combining the theoretical, clinical and mathematical studies bases on good practice and evidence-based foundation, the establishment of viral pneumonia on the theoretical system of Chinese medicine and traditional Chinese medicine, diagnosis and treatment of objectivity, standardization, standardization of enlightening.
2. Study the academic thought of famous veteran doctors of TCM, using the traditional Chinese medicine theory of knowledge and modern research methods (including data mining), with refined pathogenesis pathological differentiation perspective and sum up the role of the law of prescription drugs is beneficial to promoting the heritage and name of the old Chinese academic thought. To mentor Professor Wang Shouchuan treatment of pneumonia, the major toxic form of academic thinking of the thermal depression refining the theory of phlegm and blood stasis disease was acute pneumonia virus basic pathogenesis pathology of TCM broad, innovative viral pneumonia theoretical system of TCM treatment laid a good foundation.
3. The TCM experimental group is better than western medicine group in improving the heat, constraint, phlegm, blood stasis and its associated pathogenesis. Application of association rules can create outstanding content of traditional Chinese medicine, more in line with Chinese characteristics and laws of TCM clinical efficacy evaluation.
数据挖掘是近20年新兴的一门交叉学科,它和数据库中的知识发现是两个等价的概念。关联规则是数据挖掘技术的最常用和较为成熟的方法之一,它描述数据库中数据项(属性、变量)之间所存在的(潜在)关系,对于突出以症状体征关联出现的中医证候学的研究具有适用性,以及通过证候学分析认识病因病机,形成病机理论。
导师汪受传教授为全国名老中医,潜心研究病毒性肺炎十五年,诊治大量本病患者,形成独立的学术思想,在理论和临床研究中探讨、应用热、郁、痰、瘀病机理论指导病毒性肺炎的辨证论治,取得良好疗效和丰硕成果。
为了对深入开展病毒性肺炎中医辨证论治的客观化和规范化研究打下良好基础,为了探讨利用现代科技手段对名老中医经验和学术思想研究、总结的新模式、新方法,在此,运用数据挖掘技术,主要运用关联规则方法,开展病毒性肺炎热郁痰瘀病机理论研究。
目的：通过理论、临床、数理研究建立病毒性肺炎病机理论。
方法：在文献研究和理论研究的基础上,运用关联规则方法,对大样本、多中心、随机分组的病毒性肺炎临床研究数据源进行挖掘,开展理论、临床、数理三结合的病毒性肺炎病机理论研究。
结果：
1、理论研究方面：通过古今文献研究发现,古代医籍中有关于肺炎病机与热、郁、痰、瘀相关的散在论述,现代也有学者提出以痰热郁闭或痰热瘀闭论治本病的观点,并有相关的临床研究报道,说明病毒性肺炎热郁痰瘀病机理论具有古代和现代专家意见的基础。
2、临床研究和数理研究方面：在临床研究的基础上,利用本病临床研究的数据源,从临床的证候学入手,进行关联规则运算,发现在发病之际,常见热邪炽盛、肺气郁阻、痰涎壅盛和血脉瘀阻(简称热、郁、痰、瘀)的病机病理。轻度患儿的热邪与正气争斗的病机改变相对较轻,而肺气郁阻与痰涎壅盛以及血脉瘀阻的病机病理已较为严重；中度患儿热邪与正气剧烈争斗、肺气郁阻和痰涎壅盛的病机病理已较为严重,而血脉瘀阻的病机病理相对较轻。重度患儿热邪炽盛、肺气郁阻与痰涎壅盛以及血脉瘀阻的病机病理均较为严重。在治疗过程中,热邪炽盛、肺气郁阻、痰涎壅盛和血脉瘀阻的病机病理均逐渐减轻。热邪炽盛的病机病理在初、中期明显,末期轻微；肺气郁阻和痰涎壅盛的病机病理在疾病全过程都较明显：血脉瘀阻的病机病理在疾病初期较为明显,在疾病中后期相当轻微或消失。在药物干预下,试验组与对照组的病机演变规律相似,但作支持度比较,大多数时间上,大多数项集(如热证候、郁证候、痰证候或热与郁关联证候、热与痰关联证候、热与郁与痰关联证候等)两组差异有显著性(P＜0.05～0.01),且试验组比对照组提前1～3天消失。说明在改善热邪炽盛、肺气郁阻、痰涎壅盛或热邪炽盛与肺气郁阻关联病机、热邪炽盛与痰涎壅盛关联病机、热邪炽盛与肺气郁阻与痰涎壅盛关联病机等方面,试验组效果优于对照组。
在疾病全过程,治疗前后都有热、郁、痰、瘀四者之间形成的2～7项的关联病机,如形成热与郁、热与痰、热与瘀、郁与痰、郁与瘀、痰与瘀、热与郁与痰、热与郁与瘀、热与痰与瘀、郁与痰与瘀、热与郁与痰与瘀等关联的病机病理,且由热致郁、致痰、致瘀,或由郁致热、致痰、致瘀,或由痰致热、致郁、致瘀,或由瘀致热、致郁、致痰的病机演变均有一定的规律性和相互作用强度的概率。其规律性和概率的变化在治疗前后有部分基本不变,而部分呈逐日下降的变化,如由郁致痰或由痰致郁的概率极高,基本上在治疗前后一致,极少发生变化。由热或痰或瘀等致郁,以及由热或郁或瘀致痰的概率极高,也基本上是治疗前后极少变化。由郁或痰或瘀致热的概率常常可见治疗后逐日下降。由瘀致热或郁或痰的概率往往大于由热或郁或痰致瘀的概率。
3.病毒性肺炎热郁痰瘀病机理论的主要内容：在病毒性肺炎中,多数由热致病,热致气郁,热炼痰蓄,气郁血瘀。同时,气机郁阻、痰涎蓄积、血脉瘀阻又是热邪不散的影响因素。热、郁、痰、瘀四者并存且相互关联,循序渐变,互为因果,环环相连,在疾病过程中极易形成热郁、热痰、热瘀、痰郁、痰瘀或热郁痰、热郁瘀、热痰瘀、痰郁瘀或热郁痰瘀互结的病机病理改变。在本病中,热邪为患是本病的始动因素,热邪与正气相争贯穿疾病的全过程,.但在药物的干预下,此病因病机有逐渐减少的变化,其他病机对此病机影响的可能性也随之降低。各种病因病机影响到肺气郁阻与痰涎壅盛病机变化的可能性很少随时间改变,肺气郁阻与痰涎壅盛病机病理在本病中甚为重要,占主导地位。痰与瘀均为有形的病理产物(尤其是后者),其影响热或郁的可能性甚于热或郁对它们的影响,在病机演变中有重要作用。
结论：
1.热、郁、痰、瘀是病毒性肺炎急性期的基本病因病机病理。通过理论、临床和数理三结合建立的病毒性肺炎热郁痰瘀病机理论,具有良好的实践基础和循证基础,对建立病毒性肺炎中医诊治理论体系和中医辨证论治客观化、规范化、标准化研究具有启迪作用。
2.运用中医传统认识论与现代研究方法(包括数据挖掘方法)相结合研究名老中医学术思想,具有提炼病机病理辨证观点和总结处方用药规律的作用,有利于传承和弘扬名老中医学术思想。以导师汪受传教授论治病毒性肺炎的主要学术思想提炼形成的热郁痰瘀病机理论,是对病毒性肺炎急性期中医基本病机病理的概括,为创新病毒性肺炎中医诊治理论体系奠定了良好基础。
3.在改善热、郁、痰、瘀及其关联病机方面,中医试验组疗效优于西药对照组。应用关联规则方法可以建立突出中医辨证论治内涵、更加符合中医特点和规律的中医临床疗效评价方法。
Pneumonia, one of four key diseases prevention in our nation, is common and frequently-occurring for children, of them viral pneumonia accounts for about 1/2. Traditional Chinese Medicine specializes in the treatment of children with viral pneumonia, have a good effect and a large number of clinical studies. Many scholars have conducted many studies with syndrome differentiation and treatment methods, and have had a certain degree of understanding. However, the methods still need objective and normalization. In the situation of Traditional Chinese Medicine Schools emphasis on Chinese traditional research methods combined with evidence-based medicine. There is necessary to deepen the study of infantile pneumonia, using traditional research methods combined with the modern science and technology, make it more objective and normalized.
Data mining is an emerging interdisciplinary in the last 20 years, which means the knowledge discovery of databases. Association rule is one of the most common and sophisticated methods in the data mining, it describes the (potential) relationship among data items in the database (attributes, variables), applies to the study on the TCM Syndrome which stress the relations between diagnostics and physical sign.
As a national well-known old TCM, my mentor Professor Wang Shouchuan has studied the viral pneumonia for 15 years, treated a large number of the patients, and formed independent academic thought. With the guide of the pathogenesis of heat-constraint-phlegm-blood stasis, he had made good effect and outcome in the treatment of viral pneumonia.
In order to lay a solid foundation for the further objective and standard research of the TCM pattern differentiation and treatment for viral pneumonia, study and summarize the experience and academic thinking of the famous veteran doctors of TCM with the modern technology, we will carry out a research of viral pneumonia concerning Heat-Constraint-Phlegm-Blood stasis Pathogenesis theory, using the data mining, mainly the Association rule.
Objective
Through the theoretical, clinical and statistical studies, establish the pathogenesis theory of viral pneumonia.
Methods
To excavate the large sample, multi-center, randomized clinical study of viral pneumonia in the data source, carry out a research of the pathogenesis theory of viral pneumonia with the theoretical, clinical and statistical studies, using association rule, on the basis of literature and theoretical studies.
Results
1. Theoretical research:
Some scattered words about the pathogenesis of pneumonia which is relative with heat, constraint, phlegm and blood stasis in the ancient medical books, by studying the ancient and modern literatures; Some modern scholars put forward treatment with phlegm-heat-constraint block or phlegm-heat-stasis block, and there are some clinical research reports about them; all this shows that the study of Heat-Depression-Phlegm-Blood stasis Pathogenesis theory has ancient and modern basis of expert advices.
2. Clinical research and mathematical research:
Using the disease data sources from clinical studies, based on clinical studies, start from the clinical Syndrome, compute association rules, it can be found that the pathogenesis of intense heat pathogen, lung qi constraint, phlegm and fluid obstruction and blood vessels stasis obstruction (the "heat, constraint, phlegm and blood stasis") often can be seen in the onset of the occasion.
The pathogenesis of overabundance of pathogenic heat is clear in the early and middle stage, slight late, while the pathogenesis of lung qi constraint and phlegm-fluid accumulation are obvious in the whole process, blood stasis obvious in the early and minor late. Pathogenesis Evolution rule of the experimental group and control group is similar in drug intervention, but more for support, most of the time, most of the itemsset (such as heat syndrome, depressive syndrome, sputum or fever syndrome associated with depression syndrome, fever syndrome associated with sputum, fever and depression associated with syndrome of phlegm, etc.) between the two groups was significant (P<0.05-0.01), and compared with the control group 1 to 3 days before disappearing. It shows that the experimental group is better than the control group in the aspects of improving the rising heat pathogen, Qi constraint, hold the spit with the rising dampness or heat evil associated with lung disease resistance machines depression, the rising heat pathogen, hold the spit dampness associated with disease pathogenesis, the rising heat pathogen and lung resistance with depression pathogenesis associated with dampness.
In the whole process of disease, heat, constraint, phlegm and blood stasis associated each other and form the 2 to 7 interrelated pathogenesis, such as the formation of hot and constraint, hot and sputum, heat and blood stasis, phlegm and depression, depression and blood stasis, phlegm and blood stasis, heat and constraint and sputum, heat and depression and blood stasis, heat and phlegm and blood stasis, phlegm and blood stasis with depression, heat and depression associated with phlegm and stasis, or heat causing constraint, causing phlegm and causing stasis, or depression causing heat, causing phlegm, resulting in stasis, or phlegm causing depression, causing heat and causing blood stasis, or stasis causing heat, causing constraint and causing phlegm. There is a probability of regularity and strength of interactions in the evolution of the pathogenesis, the changes of the regularity and probability almost stay the same before and after treatment. By thermal or induced sputum or blood, etc. Depression and depression from the heat or phlegm or blood stasis caused by high probability, it is basically little changed before and after treatment. From the phlegm or blood caused by depression or the probability of heat treatment often can be seen daily decline. Stasis caused by the heat or the probability of depression or sputum is often greater than the heat or depression or the probability of stasis caused by phlegm.
3. The main content of heat-constraint-phlegm-stasis pathogenesis theory about viral pneumonia:
In viral pneumonia, the majority of pathogens from the heat, heat induced Qi constraint, phlegm accumulation due to heat, blood stasis due to qi constraint. Meanwhile, Qi constraint, phlegm accumulation, blood stasis are the factors which make heat pathogen retention. Heat, constrain, phlegm, blood stasis and the coexistence of the four inter-related, progressive gradual, reciprocal causation, ring linked to the disease process is extremely easy in the formation of thermal depression, the pathogenesis of heat-constraint, heat-phlegm, heat-stasis, phlegm-constraint, phlegm-stasis, or heat-constraint-phlegm, heat-constraint-stasis, phlegm-constraint-stasis, or binding of heat-constraint-phlegm-stasis often can be seen in the course of this disease. In this disease, the heat pathogen infestation is the initiating factor of this disease, the struggle between heat pathogen and healthy qi throughout the whole process of the disease, but under the drug intervention, the disease has gradually decreased due to illness changes, so dose the possible influence of the other pathogenesis. The possibilities of various etiology and pathogenesis will influence the pathogenesis variation of lung qi constraint and phlegm-fluid accumulation little change over time, and they are important pathogenesis in this disease and took the domination position. Phlegm and blood stasis are also the product of physical pathology, especially the blood stasis, which influence to the heat and stasis was larger than heat and stasis to them, play an important role in the evolution of pathogenesis.
Conclusion
1. Heat, constraint, phlegm and blood stasis are the basic pathogenesis of the acute viral pneumonia. This pathogenesis theory of viral pneumonia established through combining the theoretical, clinical and mathematical studies bases on good practice and evidence-based foundation, the establishment of viral pneumonia on the theoretical system of Chinese medicine and traditional Chinese medicine, diagnosis and treatment of objectivity, standardization, standardization of enlightening.
2. Study the academic thought of famous veteran doctors of TCM, using the traditional Chinese medicine theory of knowledge and modern research methods (including data mining), with refined pathogenesis pathological differentiation perspective and sum up the role of the law of prescription drugs is beneficial to promoting the heritage and name of the old Chinese academic thought. To mentor Professor Wang Shouchuan treatment of pneumonia, the major toxic form of academic thinking of the thermal depression refining the theory of phlegm and blood stasis disease was acute pneumonia virus basic pathogenesis pathology of TCM broad, innovative viral pneumonia theoretical system of TCM treatment laid a good foundation.
3. The TCM experimental group is better than western medicine group in improving the heat, constraint, phlegm, blood stasis and its associated pathogenesis. Application of association rules can create outstanding content of traditional Chinese medicine, more in line with Chinese characteristics and laws of TCM clinical efficacy evaluation.
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