广西汉族多发性肌炎/皮肌炎与HLA-DQA1、-DQB1等位基因的相关性研究
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摘要
目的：研究广西汉族多发性肌炎/皮肌炎(PM/DM)与HLA-DQA1.-DQB1等位基因的相关性。
方法：采用聚合酶链反应-序列特异性引物(Polymerase chain reaction-special sequence primers,PCR-SSP)的方法,对广西地区汉族53例PM/DM患者和汉族100例健康对照者进行HLA-DQA110个、-DQB15个等位基因分型。
结果：1.HLA-DQA1等位基因频率分布
PM/DM患者组中,检出10个等位基因,基因频率范围为0.057～0.340。其中,DQA1*0101、*0102、*0302等位基因频率较高(分别为0.340、0.255.0.226),DQA1*0201、*0501、*0601等位基因频率较低(分别为0.057、0.094、0.057)。对照组中,检出10个等位基因,基因频率范围为0.015～0.260。其中,DQA1*0101、*0102、*0104、*0302等位基因频率较高(分别为0.260、0.215、0.240),DQA1*0103、*0302、*0601等位基因频率较低(分别为0.065、0.015、0.035、0.060)。
2.HLA-DQB1等位基因频率分布
PM/DM患者组中,检出5个等位基因,基因频率范围为0.009～0.123。其中DQB1*0301等位基因的频率较高(为0.094),DQB1*0201、*0401频率较低(为0.047、0.019)。对照组中,检出4个等位基因,基因频率范围为0.000～0.095。其中DQB1*0301等位基因的频率较高(为0.085),DQB1*0501、*0601频率较低(分别为0.070、0.055)。
3.HLA-DQA1、-DQB1等位基因频率比较
PM/DM患者组与正常对照组比较,PM/DM患者组HLA-DQA1*0302、*0401等位基因频率呈显著增高,差异有显著性(OR值分别为26.759、5.244；P值分别为0.000、0.000,校正Pc值分别为0.000,0.004)。而等位基因HLA-DQA1*0201.*0501频率降低(OR值分别为0.328、0.413；P值分别为(0.018、0.028),但校正Pc>0.05,无统计学意义。
4.伴间质性肺炎组HLA-DQA1、-DQB1等位基因分布
4.1PM/DM伴间质性肺炎患者组中,HLA-DQA1检出9个等位基因,基因频率范围为0.026～0.395。其中DQA1*0102、*0104、*0401等位基因的频率较高(分别为0.211、0.237、0.237),DQA1*0103、*0501频率较低(分别为0.079、0.079),DQA1*0201未检出。
4.2PM/DM伴间质性肺炎患者组中,HLA-DQB1检出5个等位基因,基因频率范围为0.026-0.132。其中DQB1*0201/、*0301等位基因的频率较高(分别为0.053、0.053),DQB1*0401、*0501频率较低(分别为0.026、0.026)。
5.不伴间质性肺炎组HLA-DQA1、-DQB1等位基因分布
5.1PM/DM不伴间质性肺炎患者组中,HLA-DQA1检出10个等位基因,基因频率范围为0.074～0.309。其中DQA1*0102、*0302等位基因的频率较高(分别为0.279、0.279),DQA1*0201、*0401频率较低(分别为0.088、0.088)。
5.2PM/DM不伴间质性肺炎患者组中,HLA-DQB1检出4个等位基因,基因频率范围为0.015-0.118。其中DQB1*0301、*0601等位基因的频率较高(分别为0.118、0.118),DQB1*0201频率较低(为0.044),DQB1*0401未检出。
6.伴间质性肺炎组和不伴间质性肺炎组HLA-DQA1、-DQB1等位基因分布比较
PM/DM患者伴间质性肺炎组等位基因HLA-DQA1*0302、*401频率明显高于正常对照组(OR值分别为11.548、11.957；P值分别为0.003、0.000,校正Pc值分别为0.026、0.000)。与正常对照组比较,PM/DM患者不伴间质性肺炎组等位基因HLA-DQA1*0302频率明显增高(OR=40.956,P=0.000, Pc=0.000),而等位基因HLA-DQB1*0501频率呈降低趋势(P=0.021),但校正Pc>0.05,无统计学意义。
结论：等位基因HLA-DQA1*0302、*0401可能是广西地区汉族PM/DM患者的易感基因。HLA-DQA1*0401可能是广西地区汉族PM/DM患者伴间质性肺炎的危险基因。
Objective:To investigate the genetic susceptibility of HLA-DQA1,-DQB1alleles to polymyositis/dermatomyositis in Chinese hans from guangxi area around.
Methods:53patients with polymyositis/dermatomyositis and100healthy controls were examined for genotypes, HLA-DQA1,-DQB1allele typing was carried out using the polymerase reaction-sequence specific primers PCR (PCR-SSP).
Results:1. HLA-DQA1allele frequency distribution
PM/DM patients group were detected10alleles, the gene frequency range of0.057-0.340. Among them, the DQA1*0101,*0102,*0302allele frequency was higher (0.340,0.255,0.226), DQA1*0201,*0501,*0601allele frequency was lower (respectively0.057,0.094,0.057). Control group were detected10alleles in the gene frequency range of0.015to0.260. Among them, the DQA1*0101,*0102,*0104,*0302allele frequency was higher (0.260,0.215,0.240), DQA1*0103,*0302,*0601allele frequency was lower (0.065,0.015,0.035,0.060).
2. HLA-DQB1allele frequencies
PM/DM patients group were detected five alleles, the gene frequency range of0.009to0.123. DQB1*0301allele frequency was higher (0.094), DQB1*0201,*0401frequency is low (0.047,0.019). The control group, were detected in the4alleles, gene frequency range of0.000to0.095. DQB1*0301allele frequency was higher (0.085), DQB1*0501,*0601frequency is lower (0.070,0.055).
3. HLA-DQA1,-DQB1alleles frequency
PM/DM patients group and normal control group, the PM/DM patients group of HLA-DQA1*0302,*0401allele frequency was significantly increased, the difference was significant (OR values were26.759,5.244; P values were0.000correction Pc value were0.000,0.000,0.004). Alleles of HLA-DQA1*0201,*0501frequency is reduced (OR value to0.328,0.413;P values were0.018,0.028), but the correction to the Pc>0.05, not statistically significant.
4. With interstitial pneumonia group, HLA-DQA1,-DQB1alleles distribution
4.1PM/DM with interstitial pneumonia patient group, the HLA-DQA1were detected in9alleles, gene frequency range of0.026-0.395. DQA1*0102,*0104,*0401allele frequency was higher (0.211,0.237,0.237), DQA1*0103,*0501frequency was lower (0.079,0.079) of DQA1*0201is not seized out.
4.2PM/DM with interstitial pneumonia patient group, the HLA-DQB1were detected five alleles, the gene frequency range of0.026-0.132. DQB1*0201,*0301allele frequency was higher (for the0.053,0.053), DQB1*0401,*0501frequency is lower (0.026,0.026).
5. Without interstitial pneumonia group, HLA-DQA1,-DQB1alleles distribution
5.1PM/DM without interstitial pneumonia patient group, the HLA-DQA1were detected in10alleles, gene frequency range from0.074to0.309, Which DQA1*0102,*0302allele frequency was higher (for the0.279,0.279), DQA1*0201,*0401frequency was lower (respectively, are0.088,0.088).
5.2PM/DM without interstitial pneumonia patient group, the HLA-DQB1were detected in the4alleles, gene frequency range of0.015to0.118. DQB1*0301,*0601allele frequency was higher (for the0.118,0.118), DQB1*0201frequency was lower (0.044), DQB1*0401were not detected.
6. With interstitial pneumonia group and without interstitial pneumonia group, HLA-DQA1,-DQB1alleles distribution
PM/DM patients with interstitial pneumonia group alleles of HLA-DQA1*0302,*0401frequency was significantly higher than the heathy control group (OR=11.548,11.957; P values were0.003,0.000; correction Pc values were0.026,0.000). Compared with the normal control group, the PM/DM patients with interstitial pneumonia group of alleles of HLA-DQA1*0302frequency was significantly higher (OR=40.956, P=0.000, Pc=0.000), while the alleles of HLA-DQB1*0501frequency was decreased (P=0.021), but correction Pc>0.05, not statistically significant.
Conclusion:Alleles of HLA-DQA1*0302,*0401have a significant genetic correlation with PM/DM, HLA-DQA1*0302,*0401with PM/DM were susceptibility genes in Guangxi Han patients with or without interstitial pneumonia may have different genetic immunological background. HLA-DQA1*0401may be dangerous gene of Han nationality in Guangxi region associated interstitial pneumonia in PM/DM patients.
方法：采用聚合酶链反应-序列特异性引物(Polymerase chain reaction-special sequence primers,PCR-SSP)的方法,对广西地区汉族53例PM/DM患者和汉族100例健康对照者进行HLA-DQA110个、-DQB15个等位基因分型。
结果：1.HLA-DQA1等位基因频率分布
PM/DM患者组中,检出10个等位基因,基因频率范围为0.057～0.340。其中,DQA1*0101、*0102、*0302等位基因频率较高(分别为0.340、0.255.0.226),DQA1*0201、*0501、*0601等位基因频率较低(分别为0.057、0.094、0.057)。对照组中,检出10个等位基因,基因频率范围为0.015～0.260。其中,DQA1*0101、*0102、*0104、*0302等位基因频率较高(分别为0.260、0.215、0.240),DQA1*0103、*0302、*0601等位基因频率较低(分别为0.065、0.015、0.035、0.060)。
2.HLA-DQB1等位基因频率分布
PM/DM患者组中,检出5个等位基因,基因频率范围为0.009～0.123。其中DQB1*0301等位基因的频率较高(为0.094),DQB1*0201、*0401频率较低(为0.047、0.019)。对照组中,检出4个等位基因,基因频率范围为0.000～0.095。其中DQB1*0301等位基因的频率较高(为0.085),DQB1*0501、*0601频率较低(分别为0.070、0.055)。
3.HLA-DQA1、-DQB1等位基因频率比较
PM/DM患者组与正常对照组比较,PM/DM患者组HLA-DQA1*0302、*0401等位基因频率呈显著增高,差异有显著性(OR值分别为26.759、5.244；P值分别为0.000、0.000,校正Pc值分别为0.000,0.004)。而等位基因HLA-DQA1*0201.*0501频率降低(OR值分别为0.328、0.413；P值分别为(0.018、0.028),但校正Pc>0.05,无统计学意义。
4.伴间质性肺炎组HLA-DQA1、-DQB1等位基因分布
4.1PM/DM伴间质性肺炎患者组中,HLA-DQA1检出9个等位基因,基因频率范围为0.026～0.395。其中DQA1*0102、*0104、*0401等位基因的频率较高(分别为0.211、0.237、0.237),DQA1*0103、*0501频率较低(分别为0.079、0.079),DQA1*0201未检出。
4.2PM/DM伴间质性肺炎患者组中,HLA-DQB1检出5个等位基因,基因频率范围为0.026-0.132。其中DQB1*0201/、*0301等位基因的频率较高(分别为0.053、0.053),DQB1*0401、*0501频率较低(分别为0.026、0.026)。
5.不伴间质性肺炎组HLA-DQA1、-DQB1等位基因分布
5.1PM/DM不伴间质性肺炎患者组中,HLA-DQA1检出10个等位基因,基因频率范围为0.074～0.309。其中DQA1*0102、*0302等位基因的频率较高(分别为0.279、0.279),DQA1*0201、*0401频率较低(分别为0.088、0.088)。
5.2PM/DM不伴间质性肺炎患者组中,HLA-DQB1检出4个等位基因,基因频率范围为0.015-0.118。其中DQB1*0301、*0601等位基因的频率较高(分别为0.118、0.118),DQB1*0201频率较低(为0.044),DQB1*0401未检出。
6.伴间质性肺炎组和不伴间质性肺炎组HLA-DQA1、-DQB1等位基因分布比较
PM/DM患者伴间质性肺炎组等位基因HLA-DQA1*0302、*401频率明显高于正常对照组(OR值分别为11.548、11.957；P值分别为0.003、0.000,校正Pc值分别为0.026、0.000)。与正常对照组比较,PM/DM患者不伴间质性肺炎组等位基因HLA-DQA1*0302频率明显增高(OR=40.956,P=0.000, Pc=0.000),而等位基因HLA-DQB1*0501频率呈降低趋势(P=0.021),但校正Pc>0.05,无统计学意义。
结论：等位基因HLA-DQA1*0302、*0401可能是广西地区汉族PM/DM患者的易感基因。HLA-DQA1*0401可能是广西地区汉族PM/DM患者伴间质性肺炎的危险基因。
Objective:To investigate the genetic susceptibility of HLA-DQA1,-DQB1alleles to polymyositis/dermatomyositis in Chinese hans from guangxi area around.
Methods:53patients with polymyositis/dermatomyositis and100healthy controls were examined for genotypes, HLA-DQA1,-DQB1allele typing was carried out using the polymerase reaction-sequence specific primers PCR (PCR-SSP).
Results:1. HLA-DQA1allele frequency distribution
PM/DM patients group were detected10alleles, the gene frequency range of0.057-0.340. Among them, the DQA1*0101,*0102,*0302allele frequency was higher (0.340,0.255,0.226), DQA1*0201,*0501,*0601allele frequency was lower (respectively0.057,0.094,0.057). Control group were detected10alleles in the gene frequency range of0.015to0.260. Among them, the DQA1*0101,*0102,*0104,*0302allele frequency was higher (0.260,0.215,0.240), DQA1*0103,*0302,*0601allele frequency was lower (0.065,0.015,0.035,0.060).
2. HLA-DQB1allele frequencies
PM/DM patients group were detected five alleles, the gene frequency range of0.009to0.123. DQB1*0301allele frequency was higher (0.094), DQB1*0201,*0401frequency is low (0.047,0.019). The control group, were detected in the4alleles, gene frequency range of0.000to0.095. DQB1*0301allele frequency was higher (0.085), DQB1*0501,*0601frequency is lower (0.070,0.055).
3. HLA-DQA1,-DQB1alleles frequency
PM/DM patients group and normal control group, the PM/DM patients group of HLA-DQA1*0302,*0401allele frequency was significantly increased, the difference was significant (OR values were26.759,5.244; P values were0.000correction Pc value were0.000,0.000,0.004). Alleles of HLA-DQA1*0201,*0501frequency is reduced (OR value to0.328,0.413;P values were0.018,0.028), but the correction to the Pc>0.05, not statistically significant.
4. With interstitial pneumonia group, HLA-DQA1,-DQB1alleles distribution
4.1PM/DM with interstitial pneumonia patient group, the HLA-DQA1were detected in9alleles, gene frequency range of0.026-0.395. DQA1*0102,*0104,*0401allele frequency was higher (0.211,0.237,0.237), DQA1*0103,*0501frequency was lower (0.079,0.079) of DQA1*0201is not seized out.
4.2PM/DM with interstitial pneumonia patient group, the HLA-DQB1were detected five alleles, the gene frequency range of0.026-0.132. DQB1*0201,*0301allele frequency was higher (for the0.053,0.053), DQB1*0401,*0501frequency is lower (0.026,0.026).
5. Without interstitial pneumonia group, HLA-DQA1,-DQB1alleles distribution
5.1PM/DM without interstitial pneumonia patient group, the HLA-DQA1were detected in10alleles, gene frequency range from0.074to0.309, Which DQA1*0102,*0302allele frequency was higher (for the0.279,0.279), DQA1*0201,*0401frequency was lower (respectively, are0.088,0.088).
5.2PM/DM without interstitial pneumonia patient group, the HLA-DQB1were detected in the4alleles, gene frequency range of0.015to0.118. DQB1*0301,*0601allele frequency was higher (for the0.118,0.118), DQB1*0201frequency was lower (0.044), DQB1*0401were not detected.
6. With interstitial pneumonia group and without interstitial pneumonia group, HLA-DQA1,-DQB1alleles distribution
PM/DM patients with interstitial pneumonia group alleles of HLA-DQA1*0302,*0401frequency was significantly higher than the heathy control group (OR=11.548,11.957; P values were0.003,0.000; correction Pc values were0.026,0.000). Compared with the normal control group, the PM/DM patients with interstitial pneumonia group of alleles of HLA-DQA1*0302frequency was significantly higher (OR=40.956, P=0.000, Pc=0.000), while the alleles of HLA-DQB1*0501frequency was decreased (P=0.021), but correction Pc>0.05, not statistically significant.
Conclusion:Alleles of HLA-DQA1*0302,*0401have a significant genetic correlation with PM/DM, HLA-DQA1*0302,*0401with PM/DM were susceptibility genes in Guangxi Han patients with or without interstitial pneumonia may have different genetic immunological background. HLA-DQA1*0401may be dangerous gene of Han nationality in Guangxi region associated interstitial pneumonia in PM/DM patients.
引文
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[1]赵辨.中国临床皮肤病学.第1版[M].江苏：江苏科学技术出版社,2009.
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[5]Tomono N, Mori M, Nakajima S, et al. HLA-DRB1*1502 is the predominant allele in Japanese patients with juvenile dermatomyositis[J]. The Journal of Rheumatology,2004,31(9):1847.
[6]边红,焉传祝.多发性肌炎/皮肌炎免疫发病机制研究进展[J].国际神经病学神经外科学杂志,2006,33(1)：86-87.
[7]王培珍,管剑龙,韩星海.特发性炎性肌病的免疫学研究进展[J].第二军医大学学报,2008,29(4)：443-445.
[8]龚非力.医学免疫学.第3版[M].北京：科学技术出版社,2009.
[9]张开明.最新皮肤科学理论与实践[M].北京：中国医药科技出版社,2011,445.
[10]Pachman LM, Jonasson O, Cannon RA, et al. HLA-B8 in juvenile dermatomyositis[J]. Lancet,1977,2(8037):567-568.
[11]Hirsch TJ, Enlow RW, Bias WB, et al. HLA-D related (DR) antigens in various kinds of myositis[J]. Hum Immunol,1981,3(2):181-186.
[12]Friedman JM, Pachman LM, Maryjowski ML, et al. Immunogenetic studies of juvenile dermatomyositis. HLA antigens in patients and their families[J]. Tissue Antigens,1983,21(1):45-49.
[13]Pachman LM, Maryjowski MC. Juvenile dermatomyositis and polymyositis[J].Clin Rheum Dis,1984,10(1):95-115.
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