蝉翼藤根及茎化学成分的研究
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摘要
蝉翼藤(Securidaca Inappendiculata Hassk．)为远志科远志族蝉翼藤属攀援灌木其根茎味辛、甘、苦，性微寒。有活血化瘀、消肿止痛、清热利尿的功效，用于跌打损伤、风湿骨痛、腰肌劳损、急慢性肠胃炎、产后恶露不净等，其茎叶常用于治疗过敏性皮疹。广西玉林制药厂生产的国家中药保护品种玉林牌正骨水和芸香精，即采用此药作为主药，且正骨水被2000年及2005年版中国药典收载，本课题组在该植物的研究工作中发现其具有一定的抗HIV病毒活性。因此，该植物具有重要的研究价值和开发前景。为了充分利用我国的植物资源，进一步开发蝉翼藤的药用部位，寻找蝉翼藤的活性成分，我们对蝉翼藤的根及茎进行了化学成分的系统研究。
从蝉翼藤根及茎中，我们分离得到了四类主要成分—(口山)酮、二苯酮、木脂体苷、皂苷等共42个化合物。通过经典的化学方法和各种先进的波谱学技术(包括IR，UV，~1H NMR，~(13)C NMR，DEPT，~1H-~1H COSY，~(13)C-~1H COSY，HMBC，TOCSY，NOESY，EI-MS，FAB-MS，ESI-MS~n)，鉴定了41个化合物。其中11个为新化合物，两个为新的天然产物，16个为首次从该属植物中分离得到。
新化合物包括1个二苯酮、3个(口山)酮、2个木脂体苷和5个皂苷，分别命名为蝉翼藤二苯酮B(2-甲氧基-3，4-亚甲二氧基二苯酮Sr01)，蝉翼藤(口山)酮E(7-羟基-1，2-二甲氧基(口山)酮Sr06)，蝉翼藤(口山)酮F(1，7-二羟基-2-甲氧基(口山)酮Sr11)，蝉翼藤(口山)酮G(3，7-二羟基-1，2，8-三甲氧基(口山)酮Sr13)，(+)丁香树脂醇4-O-β-D-葡糖-(1→4)-葡糖-4′-O-β-D-葡糖苷(Sb04)，(+)丁香树脂醇4-O-β-D-葡糖-(1→4)-β-D-葡糖-4′-O-β-D-葡糖-(1→4)-β-D-葡糖苷(Sb05)，蝉翼藤皂苷C
Securidaca inappendiculata Hassk. (polygalaceae) is distributed in tropical regions of Asia included Yunnan, Guangxi, Guangdong and Hainan provinces of China. The roots and stems of the plant were used as anti-inflammatory, antibacterial and antirheumatism agents with names "Chan Yi Teng", "Wu Wei Teng " and "Diu Le Bang" in the south of China. Previous screening studies in our group showed that the crude extract of S. inappendiculata exhibited potent anti-HIV, anti-oxidant and nuropharmacological activities. As a result, the main aim of the present study was to find active compounds from the stems and roots of S. inappendiculata collected from Yunnan province.
Phytochemical studies in the present study had led to the isolation of 42 compounds using different chromatographic techniques and subsequently the structures were elucidated by using spectrometric approaches, including IR, UV, 1D and 2D NMR, EI-MS, FAB-MS, ESI-MS~n etc., and classical chemical methods. Of the 41 compounds identified, 11 of them were found to be new compounds, 2 to be new natural products and 16 isolated from this genus for the first time.
The new compounds consisted of three xanthones, one benzophenone, five saponins, and two olegansides and named as securixanthone E (Sr06), securixanthone F (Sr11), securixanthone G (Sr13), securibenzophenone B (Sr01), securioside C (Sb10), securioside D (Sb11), securioside E (Sr23), securioside F (Sr24), securioside G (Sr25), (+) syringaresinol 4-O-β-D-glucopyranosyl-(1→4) -β-D-glucopyranosyl-4'-O-β-D-gIucopyranoside (Sb04), (+) syringaresinol 4-O-β-D-glucopyranosy-(1→4)-β-D-glucopyranosyl-4'-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (Sb05), respectively, whilst two new natural products were
从蝉翼藤根及茎中，我们分离得到了四类主要成分—(口山)酮、二苯酮、木脂体苷、皂苷等共42个化合物。通过经典的化学方法和各种先进的波谱学技术(包括IR，UV，~1H NMR，~(13)C NMR，DEPT，~1H-~1H COSY，~(13)C-~1H COSY，HMBC，TOCSY，NOESY，EI-MS，FAB-MS，ESI-MS~n)，鉴定了41个化合物。其中11个为新化合物，两个为新的天然产物，16个为首次从该属植物中分离得到。
新化合物包括1个二苯酮、3个(口山)酮、2个木脂体苷和5个皂苷，分别命名为蝉翼藤二苯酮B(2-甲氧基-3，4-亚甲二氧基二苯酮Sr01)，蝉翼藤(口山)酮E(7-羟基-1，2-二甲氧基(口山)酮Sr06)，蝉翼藤(口山)酮F(1，7-二羟基-2-甲氧基(口山)酮Sr11)，蝉翼藤(口山)酮G(3，7-二羟基-1，2，8-三甲氧基(口山)酮Sr13)，(+)丁香树脂醇4-O-β-D-葡糖-(1→4)-葡糖-4′-O-β-D-葡糖苷(Sb04)，(+)丁香树脂醇4-O-β-D-葡糖-(1→4)-β-D-葡糖-4′-O-β-D-葡糖-(1→4)-β-D-葡糖苷(Sb05)，蝉翼藤皂苷C
Securidaca inappendiculata Hassk. (polygalaceae) is distributed in tropical regions of Asia included Yunnan, Guangxi, Guangdong and Hainan provinces of China. The roots and stems of the plant were used as anti-inflammatory, antibacterial and antirheumatism agents with names "Chan Yi Teng", "Wu Wei Teng " and "Diu Le Bang" in the south of China. Previous screening studies in our group showed that the crude extract of S. inappendiculata exhibited potent anti-HIV, anti-oxidant and nuropharmacological activities. As a result, the main aim of the present study was to find active compounds from the stems and roots of S. inappendiculata collected from Yunnan province.
Phytochemical studies in the present study had led to the isolation of 42 compounds using different chromatographic techniques and subsequently the structures were elucidated by using spectrometric approaches, including IR, UV, 1D and 2D NMR, EI-MS, FAB-MS, ESI-MS~n etc., and classical chemical methods. Of the 41 compounds identified, 11 of them were found to be new compounds, 2 to be new natural products and 16 isolated from this genus for the first time.
The new compounds consisted of three xanthones, one benzophenone, five saponins, and two olegansides and named as securixanthone E (Sr06), securixanthone F (Sr11), securixanthone G (Sr13), securibenzophenone B (Sr01), securioside C (Sb10), securioside D (Sb11), securioside E (Sr23), securioside F (Sr24), securioside G (Sr25), (+) syringaresinol 4-O-β-D-glucopyranosyl-(1→4) -β-D-glucopyranosyl-4'-O-β-D-gIucopyranoside (Sb04), (+) syringaresinol 4-O-β-D-glucopyranosy-(1→4)-β-D-glucopyranosyl-4'-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (Sb05), respectively, whilst two new natural products were
引文
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