胡荫奇主任医师治疗强直性脊柱炎学术思想总结及辨治经验研究
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摘要
胡荫奇主任医师从事中医临床医疗、教学、科研工作40余年,是我国著名的风湿病学家。其治疗强直性脊柱炎经验丰富,有自己独到的认识与见解,临床疗效显著。本文对老师治疗强直性脊柱炎学术思想及辨治经验进行总结研究。
首先对当代名老中医论治强直性脊柱炎临床经验进行总结,本病中医病名尚未统一,多认为其属于“肾痹”、“骨痹”、“大偻”范畴。其发生根本原因在于先天肝肾不足、肾督亏虚。疾病治疗多分为活动期和缓解期。活动期多属湿热偏盛或者湿热毒瘀证。治疗以清热解毒,化湿通络为原则。稳定期以补益肝肾、温肾壮督为原则。强调化痰通瘀治疗的重要意义。在辨证论治的同时,多注重引经药物的使用,以增加疗效。
老师深谙经典理论,博采众家之长,结合多年临床实践,提出独到见解。他认为：强直性脊柱炎早期以“脊强”命名较为贴切,病至后期,出现腰背弯曲,不能伸直时,则应冠名为“背偻”。本病的病因病机应从虚、邪、痰瘀几方面认识,即：肝肾不足是发病之根本；邪气潜伏是发病之根源；后期易出现痰瘀互结,胶着于经隧骨骱。
临床辨证宜以脏腑辨证为主,经络辨证与气血津液辨证灵活结合。治疗上根据现代医学上骶髂关节、腰椎等部位的影像学改变,分为早、中、晚期,每一期根据患者临床表现及相关检查,分为活动期和稳定期。以各期不同临床表现特点及病理变化辨证论治。活动期以湿热痹阻证多见,处方以四妙散、四妙勇安汤及当归拈痛汤加减治疗。疾病早期病情稳定者,多辨证为肝肾不足、寒湿痹阻证,处方以阳和汤加减治疗。疾病后期,临床腰背疼痛不甚,以脊柱僵直或强直畸形等筋骨受损为主要表现者,则以补益肝肾为重点,据阴阳虚损之不同,给予滋养肝肾或温肾壮督之治疗。本病发病始终均存在不同程度的瘀血症状,所以活血行血.是治疗本病的基本方法。病至中晚期,常出现痰瘀痹阻证候,特别是病久椎体韧带钙化而致腰背僵直、活动受限者,应重视化痰软坚散结的治疗。
强直性脊柱炎发病主要累及骶髂关节、髋关节、椎间关节及肋椎关节等。约1／3患者可见周围关节症状,还可累及眼、心、肺等多器官。老师在辨证治疗的同时,根据不同临床症状,如中轴关节疼痛、外周关节肿胀疼痛等情况,酌情选用具有针对性治疗意义的药物,可以大大增加疗效。另外,根据患者疼痛不同部分,导师灵活选用些针对性治疗药物增加疗效。如：颈肩部疼痛者,可选用葛根、自芷、片姜黄、羌活、白芍等；脊背部疼痛者常酌加全蝎、蜈蚣、佣蚕等补肾通督。胸痛者则选用元胡檀香、三七及虫蛇类药物以通络,同时酌加郁金、香附、枳壳等入肝经行气解郁之剂；足跟疼痛者,导师常于方中加用红花、川断、桑寄生、威灵仙等。在临床上还常常根据疾病症状出现的部位,结合经络循行部位,进行循经辨证,在临床遣方用药时,可根据药味的归经,增强药物治疗的定位,提高疗效。如：腰背颈项僵痛者,属太阳经病证,常加用羌活、防风、藁本、葛根等归膀胱经之剂。对于强直性脊柱炎病程久,痰瘀痹阻关节骨骱,脊背僵痛不舒、转侧俯仰受限,关节漫肿难消者,此时非一般草木所能奏效,需借虫蛇走窜搜剔之功,穿透筋骨,祛浊逐瘀。在使用虫类药物时,导师强调在辨证准确的前提下,注意药物之间的配伍。
在强直性脊柱炎治疗中,老师常常选择两味以上的药物,或相辅相成,既复合了中医“七情”配伍原则,又有现代药理学新进展的灵活应用。临床应用往往事半功倍,形成了其治疗强直性脊柱炎的特色。常用的药对有：鳖甲和三七粉、羌活和独活、半枝莲和细辛、徐长卿和穿山龙等。
老师治疗用药平和,在祛风湿除痹治疗时常常注意顾护正气。如治疗湿热痹阻证时,常使用土茯苓以清热利湿,除非舌苔厚腻者,否则少用茵陈,因茵陈苦寒宜伤阴。又如选用的祛风通络药物常用鸡血藤、徐长卿等。其中鸡血藤最为多用,因其药性平和,且无副作用。徐长卿也较常用,因其药性平和,性温而不燥,散中有补,补中有散,不仅具有祛风除湿、通络止痛之功效,尚兼有扶正作用。病至后期,不主张一味温补肾阳,提倡阴阳双补。应用温补肾阳的药物,常选用阴阳平调之剂,从而达到阴中求阳的目的。导师循古而不拘于古,临床治疗风湿病主张在中医辨证用药的基础上,选用一些经现代药理研究证实对风湿病具有针对性治疗作用的药物,明显提高了临床治疗效果。对于强直性脊柱炎,导师一贯提倡综合性治疗以提高疗效。他常常在诊治过程中指导患者进行适度的功能锻炼,增加肌肉力量,保持关节旁韧带柔韧性及关节活动度。另外,对于出现椎体僵直、活动受限或外周关节症状明显患者,还要配合局部中药热敷及中频导入治疗以缓解症状。
为进一步总结导师治疗强直性脊柱炎的经验,我们选取经导师治疗临床有效患者,通过收集和分析其门诊病例资料,对其用药规律进行了初步研究。本次研究选取病例189例,共收集387人次的门诊资料,中药处方395张。使用频数法对导师治疗强直性脊柱炎的常用药物使用频次(百分率＞10％)及其临床使用药物的性味归经进行统计。结果可见使用频率在10%以上的药物有49味。这些药物性味多为辛甘苦,以温性药物为主,其次是寒性药物。药物归经以肝肾经为主。将以上常用药物在每张处方的使用情况输入数据库,以49种常用药物作为变量,对这些药物进行聚类分析。初步总结出导师常用药物有以下几类：祛风湿药物、通经止痛药物、补益肝肾药物、活血逐瘀药物、软坚散结药物、清热利湿类药物及养阴清热类药物。使用SPSS18.0统计软件中的Pearson correlation(皮尔逊相关)方法,计算导师395张处方中各中药之间的相关系数,相关系数>0.300的有25对,总结导师治疗强直性脊柱炎常用药对,并对常用药物及药物之间的配伍意义进行分析。借助计算机技术和数据挖掘等方法从临床实证出发,对名中医的学术经验进行总结,既验证了临床总结之经验,并有可能从数据分析中发现确实存在但尚未被专家升华为“经验”的独特用药特色。
以导师的学术思想及辨治经验为指导原则,采用辨证论治的方法治疗强直性脊柱炎,观察临床疗效。结果表明,运用导师经验方治疗强直性脊柱炎可以明显的改善患者临床症状、控制疾病活动、控制病情进展的作用。同时,也将跟师过程中总结的导师经验,再次运用到临床中,得到临床验证,提高了研究的科学性和可重复性。
Professor Hu Yinqi dedicates his life to rheumatism of traditional Chinese medicine more than40years, including the fields of clinical practice, research and teaching. He has formed his own theory in treating ankylosing spondylitis and its pattern identification,which is worthinheriting and further approaching. This article is the Summary of research on the academic thinking on teacher treatment of ankylosing spondylitis and Treating experience.
First on the contemporary name of traditional Chinese medicine on treating ankylosing spondylitis clinical experience summary. This disease in TCM disease names have not yet been reunified, many believe that it belongs to "kidney obstruction","bone-bi","big Lv" category. Its root cause is congenital deficiency of liver and kidney and kidney deficiency of Governor Patten. Disease is divided into active and stable. Activities are sung or of dampness-heat syndrome of damp-heat toxin and stasis. Treatment of heat-clearing and detoxifying, dampness and dredging collaterals on the principle. Stable to the principle of tonifying the liver and kidney and warming kidney and strengthening supervision. Stressed the importance of phlegm and blood stasis in treatment. In the diagnosis and treatment at the same time, more emphasis on the cited drug use, in order to increase efficacy. Professor Hu said early ankylosing spondylitis "Ji-qiang" named more appropriately, of late, back bending occurs, when you cannot be straightened, it should be named as "Bei-lv". Etiology and pathogenesis of this disease should be imaginary, evil, and the Phlegm several aspects of understanding. Clinical syndrome differentiation should be dominated by Zang-Fu differentiation, Meridian differentiation of syndrome and syndrome of m-blood syndrome differentiation of body fluid and flexible combination. On the treatment of sac ro iliac joint, based on modern medical imaging of the lumbar spine and other parts, divided into early, middle, late, each period based on the clinical manifestations and the related checks, are divided into active and stable. The treatment based on syndrome differentiation of different clinical manifestations and pathological changes in the period. This sickness morbidity has the varying degree throughout the ecchymosis symptom, therefore invigorates the blood the good blood treats the essential method which the book gets sick. The disease to the late, often appear Phlegm Blockage of certificate designate, in particular the disease as long as vertebral ligament calcification Erzhi back stiffness, activity is limited by attention should be paid a phlegm Endometriosis treatment.
Pathogenesis of ankylosing spondylitis involving the sacroiliac joint, hip joint, facet and rib vertebral joints. About1/3of patients with visible symptoms of peripheral joints may also involve the eyes, heart, lung and many other organs. while dialectical treatment, according to the different clinical symptom, Professor Hu often uses judgment to select has the pointed treatment significance medicine, may increase the curative effect greatly. Also, according to a different part of the patients with pain, instructors flexibility in selecting a number of targeted therapy to increase efficacy. in clinical practice according to the site of the symptoms of the disease, Professor Hu often combined with the meridian line parts, followed by dialectical, according to the Smell of Meridian, and enhance the positioning of the drug treatment, to improve efficacy in clinical Herbal Prescription.
in the treatment of ankylosing spondylitis, teachers often choose more than two drugs, or complementary, compound traditional Chinese medicine "the seven emotions" principle of compatibility, and modern pharmacology development of flexible applications. This is one of his formation of its treatment for ankylosing spondylitis characteristics.
Professor Hu treats the medication to be gentle, when dispels rheumatism except fheiimatism Ireatment pays altention frequently attends to protects the healthy tendency. Disease to the late, do not advocate blindly warming yang, promoting yin and yang, double up. Application of warming and recuperating kidney Yang drugs, often use flat regulation of agents of yin and Yang, so as to achieve the aim of seeking Yang in yin. Clinical treatment of rheumatism argued in TCM differentiation on the basis of selection were confirmed through modern pharmacological research on rheumatic diseases targeted therapeutic drug, significantly improving the clinical treatment effects. For ankylosing spondylitis, the tutor has consistently advocated a comprehensive treatment to improve the outcome. He frequently instructs the patient in the diagnosis process to carry on the moderate function exercise, increases the muscle strength, maintains nearby the joint the ligament flexibility and the joint activity. For the spine rigid, activities are limited or peripheral joint symptoms Clear Patient, but also to tie in with local Chinese medicine thermal and mid import treatment to relieve the symptoms.
For further summarizes teacher to treat the strong straight rachitis the experience, we select after teacher treat the clinical effective patient, through collects and analyzes its outpatient service case of illness material, has conducted the preliminary study to its medication rule. This study selected cases of189cases,387people out-patient data collected395traditional Chinese medicine prescriptions. Use frequency of mentors in the treatment of ankyiosing spondylitis by common drug use frequency (percentage>10%) and its clinical use of drugs by statistics, it can be seen in the frequency of use for more than10per cent have a49. Taste of these drugs for more than two people, with a temperature of drug-based, followed by winter, drug in the liver kidney. The commonly used drugs in the usage of each prescription entered into the database,49kinds of commonly used drugs as a variable cluster analysis of these drugs. Preliminary summary of the instructors commonly used drugs arc the following categories:rheumatism drugs pass through the pain medications, liver and kidney tonic drugs, blood stasis drugs Endometriosis drugs, heat and dampness drugs and clearing away heat and drugs. Uses in SPSS18.0statistical software Pearson correlation (Pearson to be connected) the method, calculates teacher in395prescriptions between various Chinese native medicines correlation coefficient, correlation coefficient>0.300has25pairs, summarizes teacher to treat the strong straight rachitis often to apply drugs to, and blends the significance to between the commonly used medicine and the medicine to carry on the analysis. With the help of computer technology and data mining methods, such as proceeding from the clinical evidence, on the summary of the academic experience of one Chinese, not only verify the clinical experience, and likely do exist but have not yet been found in the data analysis experts into "experience" of the unique characteristics of drug use.
首先对当代名老中医论治强直性脊柱炎临床经验进行总结,本病中医病名尚未统一,多认为其属于“肾痹”、“骨痹”、“大偻”范畴。其发生根本原因在于先天肝肾不足、肾督亏虚。疾病治疗多分为活动期和缓解期。活动期多属湿热偏盛或者湿热毒瘀证。治疗以清热解毒,化湿通络为原则。稳定期以补益肝肾、温肾壮督为原则。强调化痰通瘀治疗的重要意义。在辨证论治的同时,多注重引经药物的使用,以增加疗效。
老师深谙经典理论,博采众家之长,结合多年临床实践,提出独到见解。他认为：强直性脊柱炎早期以“脊强”命名较为贴切,病至后期,出现腰背弯曲,不能伸直时,则应冠名为“背偻”。本病的病因病机应从虚、邪、痰瘀几方面认识,即：肝肾不足是发病之根本；邪气潜伏是发病之根源；后期易出现痰瘀互结,胶着于经隧骨骱。
临床辨证宜以脏腑辨证为主,经络辨证与气血津液辨证灵活结合。治疗上根据现代医学上骶髂关节、腰椎等部位的影像学改变,分为早、中、晚期,每一期根据患者临床表现及相关检查,分为活动期和稳定期。以各期不同临床表现特点及病理变化辨证论治。活动期以湿热痹阻证多见,处方以四妙散、四妙勇安汤及当归拈痛汤加减治疗。疾病早期病情稳定者,多辨证为肝肾不足、寒湿痹阻证,处方以阳和汤加减治疗。疾病后期,临床腰背疼痛不甚,以脊柱僵直或强直畸形等筋骨受损为主要表现者,则以补益肝肾为重点,据阴阳虚损之不同,给予滋养肝肾或温肾壮督之治疗。本病发病始终均存在不同程度的瘀血症状,所以活血行血.是治疗本病的基本方法。病至中晚期,常出现痰瘀痹阻证候,特别是病久椎体韧带钙化而致腰背僵直、活动受限者,应重视化痰软坚散结的治疗。
强直性脊柱炎发病主要累及骶髂关节、髋关节、椎间关节及肋椎关节等。约1／3患者可见周围关节症状,还可累及眼、心、肺等多器官。老师在辨证治疗的同时,根据不同临床症状,如中轴关节疼痛、外周关节肿胀疼痛等情况,酌情选用具有针对性治疗意义的药物,可以大大增加疗效。另外,根据患者疼痛不同部分,导师灵活选用些针对性治疗药物增加疗效。如：颈肩部疼痛者,可选用葛根、自芷、片姜黄、羌活、白芍等；脊背部疼痛者常酌加全蝎、蜈蚣、佣蚕等补肾通督。胸痛者则选用元胡檀香、三七及虫蛇类药物以通络,同时酌加郁金、香附、枳壳等入肝经行气解郁之剂；足跟疼痛者,导师常于方中加用红花、川断、桑寄生、威灵仙等。在临床上还常常根据疾病症状出现的部位,结合经络循行部位,进行循经辨证,在临床遣方用药时,可根据药味的归经,增强药物治疗的定位,提高疗效。如：腰背颈项僵痛者,属太阳经病证,常加用羌活、防风、藁本、葛根等归膀胱经之剂。对于强直性脊柱炎病程久,痰瘀痹阻关节骨骱,脊背僵痛不舒、转侧俯仰受限,关节漫肿难消者,此时非一般草木所能奏效,需借虫蛇走窜搜剔之功,穿透筋骨,祛浊逐瘀。在使用虫类药物时,导师强调在辨证准确的前提下,注意药物之间的配伍。
在强直性脊柱炎治疗中,老师常常选择两味以上的药物,或相辅相成,既复合了中医“七情”配伍原则,又有现代药理学新进展的灵活应用。临床应用往往事半功倍,形成了其治疗强直性脊柱炎的特色。常用的药对有：鳖甲和三七粉、羌活和独活、半枝莲和细辛、徐长卿和穿山龙等。
老师治疗用药平和,在祛风湿除痹治疗时常常注意顾护正气。如治疗湿热痹阻证时,常使用土茯苓以清热利湿,除非舌苔厚腻者,否则少用茵陈,因茵陈苦寒宜伤阴。又如选用的祛风通络药物常用鸡血藤、徐长卿等。其中鸡血藤最为多用,因其药性平和,且无副作用。徐长卿也较常用,因其药性平和,性温而不燥,散中有补,补中有散,不仅具有祛风除湿、通络止痛之功效,尚兼有扶正作用。病至后期,不主张一味温补肾阳,提倡阴阳双补。应用温补肾阳的药物,常选用阴阳平调之剂,从而达到阴中求阳的目的。导师循古而不拘于古,临床治疗风湿病主张在中医辨证用药的基础上,选用一些经现代药理研究证实对风湿病具有针对性治疗作用的药物,明显提高了临床治疗效果。对于强直性脊柱炎,导师一贯提倡综合性治疗以提高疗效。他常常在诊治过程中指导患者进行适度的功能锻炼,增加肌肉力量,保持关节旁韧带柔韧性及关节活动度。另外,对于出现椎体僵直、活动受限或外周关节症状明显患者,还要配合局部中药热敷及中频导入治疗以缓解症状。
为进一步总结导师治疗强直性脊柱炎的经验,我们选取经导师治疗临床有效患者,通过收集和分析其门诊病例资料,对其用药规律进行了初步研究。本次研究选取病例189例,共收集387人次的门诊资料,中药处方395张。使用频数法对导师治疗强直性脊柱炎的常用药物使用频次(百分率＞10％)及其临床使用药物的性味归经进行统计。结果可见使用频率在10%以上的药物有49味。这些药物性味多为辛甘苦,以温性药物为主,其次是寒性药物。药物归经以肝肾经为主。将以上常用药物在每张处方的使用情况输入数据库,以49种常用药物作为变量,对这些药物进行聚类分析。初步总结出导师常用药物有以下几类：祛风湿药物、通经止痛药物、补益肝肾药物、活血逐瘀药物、软坚散结药物、清热利湿类药物及养阴清热类药物。使用SPSS18.0统计软件中的Pearson correlation(皮尔逊相关)方法,计算导师395张处方中各中药之间的相关系数,相关系数>0.300的有25对,总结导师治疗强直性脊柱炎常用药对,并对常用药物及药物之间的配伍意义进行分析。借助计算机技术和数据挖掘等方法从临床实证出发,对名中医的学术经验进行总结,既验证了临床总结之经验,并有可能从数据分析中发现确实存在但尚未被专家升华为“经验”的独特用药特色。
以导师的学术思想及辨治经验为指导原则,采用辨证论治的方法治疗强直性脊柱炎,观察临床疗效。结果表明,运用导师经验方治疗强直性脊柱炎可以明显的改善患者临床症状、控制疾病活动、控制病情进展的作用。同时,也将跟师过程中总结的导师经验,再次运用到临床中,得到临床验证,提高了研究的科学性和可重复性。
Professor Hu Yinqi dedicates his life to rheumatism of traditional Chinese medicine more than40years, including the fields of clinical practice, research and teaching. He has formed his own theory in treating ankylosing spondylitis and its pattern identification,which is worthinheriting and further approaching. This article is the Summary of research on the academic thinking on teacher treatment of ankylosing spondylitis and Treating experience.
First on the contemporary name of traditional Chinese medicine on treating ankylosing spondylitis clinical experience summary. This disease in TCM disease names have not yet been reunified, many believe that it belongs to "kidney obstruction","bone-bi","big Lv" category. Its root cause is congenital deficiency of liver and kidney and kidney deficiency of Governor Patten. Disease is divided into active and stable. Activities are sung or of dampness-heat syndrome of damp-heat toxin and stasis. Treatment of heat-clearing and detoxifying, dampness and dredging collaterals on the principle. Stable to the principle of tonifying the liver and kidney and warming kidney and strengthening supervision. Stressed the importance of phlegm and blood stasis in treatment. In the diagnosis and treatment at the same time, more emphasis on the cited drug use, in order to increase efficacy. Professor Hu said early ankylosing spondylitis "Ji-qiang" named more appropriately, of late, back bending occurs, when you cannot be straightened, it should be named as "Bei-lv". Etiology and pathogenesis of this disease should be imaginary, evil, and the Phlegm several aspects of understanding. Clinical syndrome differentiation should be dominated by Zang-Fu differentiation, Meridian differentiation of syndrome and syndrome of m-blood syndrome differentiation of body fluid and flexible combination. On the treatment of sac ro iliac joint, based on modern medical imaging of the lumbar spine and other parts, divided into early, middle, late, each period based on the clinical manifestations and the related checks, are divided into active and stable. The treatment based on syndrome differentiation of different clinical manifestations and pathological changes in the period. This sickness morbidity has the varying degree throughout the ecchymosis symptom, therefore invigorates the blood the good blood treats the essential method which the book gets sick. The disease to the late, often appear Phlegm Blockage of certificate designate, in particular the disease as long as vertebral ligament calcification Erzhi back stiffness, activity is limited by attention should be paid a phlegm Endometriosis treatment.
Pathogenesis of ankylosing spondylitis involving the sacroiliac joint, hip joint, facet and rib vertebral joints. About1/3of patients with visible symptoms of peripheral joints may also involve the eyes, heart, lung and many other organs. while dialectical treatment, according to the different clinical symptom, Professor Hu often uses judgment to select has the pointed treatment significance medicine, may increase the curative effect greatly. Also, according to a different part of the patients with pain, instructors flexibility in selecting a number of targeted therapy to increase efficacy. in clinical practice according to the site of the symptoms of the disease, Professor Hu often combined with the meridian line parts, followed by dialectical, according to the Smell of Meridian, and enhance the positioning of the drug treatment, to improve efficacy in clinical Herbal Prescription.
in the treatment of ankylosing spondylitis, teachers often choose more than two drugs, or complementary, compound traditional Chinese medicine "the seven emotions" principle of compatibility, and modern pharmacology development of flexible applications. This is one of his formation of its treatment for ankylosing spondylitis characteristics.
Professor Hu treats the medication to be gentle, when dispels rheumatism except fheiimatism Ireatment pays altention frequently attends to protects the healthy tendency. Disease to the late, do not advocate blindly warming yang, promoting yin and yang, double up. Application of warming and recuperating kidney Yang drugs, often use flat regulation of agents of yin and Yang, so as to achieve the aim of seeking Yang in yin. Clinical treatment of rheumatism argued in TCM differentiation on the basis of selection were confirmed through modern pharmacological research on rheumatic diseases targeted therapeutic drug, significantly improving the clinical treatment effects. For ankylosing spondylitis, the tutor has consistently advocated a comprehensive treatment to improve the outcome. He frequently instructs the patient in the diagnosis process to carry on the moderate function exercise, increases the muscle strength, maintains nearby the joint the ligament flexibility and the joint activity. For the spine rigid, activities are limited or peripheral joint symptoms Clear Patient, but also to tie in with local Chinese medicine thermal and mid import treatment to relieve the symptoms.
For further summarizes teacher to treat the strong straight rachitis the experience, we select after teacher treat the clinical effective patient, through collects and analyzes its outpatient service case of illness material, has conducted the preliminary study to its medication rule. This study selected cases of189cases,387people out-patient data collected395traditional Chinese medicine prescriptions. Use frequency of mentors in the treatment of ankyiosing spondylitis by common drug use frequency (percentage>10%) and its clinical use of drugs by statistics, it can be seen in the frequency of use for more than10per cent have a49. Taste of these drugs for more than two people, with a temperature of drug-based, followed by winter, drug in the liver kidney. The commonly used drugs in the usage of each prescription entered into the database,49kinds of commonly used drugs as a variable cluster analysis of these drugs. Preliminary summary of the instructors commonly used drugs arc the following categories:rheumatism drugs pass through the pain medications, liver and kidney tonic drugs, blood stasis drugs Endometriosis drugs, heat and dampness drugs and clearing away heat and drugs. Uses in SPSS18.0statistical software Pearson correlation (Pearson to be connected) the method, calculates teacher in395prescriptions between various Chinese native medicines correlation coefficient, correlation coefficient>0.300has25pairs, summarizes teacher to treat the strong straight rachitis often to apply drugs to, and blends the significance to between the commonly used medicine and the medicine to carry on the analysis. With the help of computer technology and data mining methods, such as proceeding from the clinical evidence, on the summary of the academic experience of one Chinese, not only verify the clinical experience, and likely do exist but have not yet been found in the data analysis experts into "experience" of the unique characteristics of drug use.
引文
1.朱良春临床中医家-朱良春北京：中国中医药出版社2001年1月第一版185.
2.焦树德强直性脊柱炎的治疗经验河北中医2004年第26卷第10期725-726.
3.项红焦树德治疗强直性脊柱炎的临床经验北京中医2003,23(3)：142-144.
4.王北.王为兰教授治疗强直性脊柱炎的临床经验.北京中医药大学学报(中医临床版)2008年9月,15(5)：23-24.
5.王鑫.房定亚运用补肾疏督法治疗强直性脊柱炎探微.上海中医药杂志2008年第42卷第7期1-2.
6.邓长财,鞠中斌.张鸣鹤治疗活动期强直性脊柱炎经验探讨.山东中医药大学学报2006,30(5)：372-373.
7.顾军花、茅建春、周时高等陈湘君运用扶正法治疗强直性脊柱炎经验撷菁土海中医药杂志2008年第42卷第3期12-13.
8.林昌松,刘晓玲,关彤等陈纪藩教授治疗强直性脊柱炎经验新中医2001年2月第33卷第2期10-11.
9.方路,许东云 舒尚义老师治疗强直性脊柱炎经验举要云南中医中药杂志2004年第29卷第6期1-2.
10.张梅红、谷万里、于秀梅等谷越涛治疗强直性脊柱炎经验 四川中医2004年第22卷第8期5-7.
11.韩善夯金实教授治疗强直性脊柱炎经验 四川中医2005,23(1)：1-2.
1.邱德文,吴元黔,熊兴平等.中国当代名老中医药专家学术经验的整理研究(上)贵阳中医学院学报,2000,22(3)；52.
2.王映辉,张润顺,吴洁等,名老中医经验传承研究模式探索.中国中医基础医学杂志,2008,14(6)：417-419.
3.邓铁涛.怎样正确认识中医.上海中医药杂志,2001,35(1)：4.
4.邓铁涛。中医成才之路。新中医2000；32(11)：11.
5.陆晴友,吴岳嵩.人工智能专家系统及其在骨科领域中的应用.中国矫形外科杂志,2005,13(1)：141-143.
6.刘保延.数字中医药与中医药的跨越式发展[J].中国中医药信息杂志,2002(08)：3-4.
7.张华,刘保延,田从豁等.“人机结合、以人为主”的名老中医经验整理研究方法.中医研究.2007,20(2)：4-6.
8.陈涛,李克乾,陈茂华,等.4400例当代名医医案的舌象分布频数分析[J].辽宁中医杂志,2007,34(9)：1217.
9.张华东,赵冰,王映辉等.谢海洲“治痹三要四宜”学术思想之信息化研究.湖北中医杂志.2008,30(11)：4-7.
10.张启明,王永炎,张志斌等.外感病因中证候要素的提取[J].山东中医药大学学报,2005,29(5)：339-341.
11.谢元华,张京春,蒋跃绒等.陈可冀辨治高血压病医案的数据挖掘分析[J].中西医结合心脑血管病杂志,2008,6(2)：135.
12.张京春,谢元华.陈可冀院士辨治冠心病医案的数据挖掘[J].世界中西医结合杂志,2008,3(1)：4.
13.叶放,陶帅,徐吉敏等.周仲瑛教授应用犀角地黄汤临床经验要素数据挖掘分析.中华中医药杂志(原中国医药学报).2010,25(10)：1577-1579.
14.田琳,闫英杰,朱建贵等.整理挖掘名老中医诊疗眩晕病辨证思维模式的思路与探讨.中国中医基础医学杂志,2006,12(8)：618-622.
15.吴荣,王阶,任延革等.基于数据挖掘的名老中医冠心病诊疗规律研究.中华中医药学刊.2008,26(12)：2581-2583.
16.王映辉,姜在旸,刘保延等.基于信息和数据挖掘技术的名老中医临床诊疗经验研究思路[J].世界科学技术·中医药现代化,2005,7(1)：98-105.
17.谭定英,老膺荣,古求知等.面向循证传承的名老中医个人医案数据挖掘研究思路初探.新中医,2011,43(8)：162-164.
1.刘吉人.中国医学大成·卷三·伏邪新书[M].长沙：岳麓书社,1990.777.
2.尤在泾.尤在泾医学全书·医学读书记[M].北京：中国中医药出版社,2002：344
3.李顺保.温病学全书[M].北京：学苑出版社,2002.352,518,20,522.519
4.尤在泾.中国医学大成·卷四·金匮翼·卷六[M].长沙：岳麓书社,1990.304.
5.蒋明,张奉春主编.风湿病诊断与诊断评析.上海：上海科学技术出版社.2004年9月第一版,166
6.胡荫奇,唐先平主编.简明中西医结合风湿病学.北京：科学技术文献出版社.2009年2月第一版,62
7.绵解对去卵巢大鼠骨代谢改变的干预作用。中国中药杂志>2007年18期
8.李中华；赵晓芳半枝莲水煎液对肝纤维化模型大鼠间质胶原和TGF-β_1的影响山东中医杂志2010年1期41-43
9.蒋明,朱立平,林孝义主编风湿病学北京：科学出版社1995年4月465
10.杨珺,邹全明.鳖甲超微细粉增加大鼠骨密度的研究[J].食品科学,2001,22(3)：86-88.
11.王全权,陈海林,宗芳,等.补骨脂复方制剂干预绝经后骨质疏松症的作用.中国临床康复,2006,35(10)：145-148。
12.杨荣平,寿清耀,涂永勤,等.补骨脂提取物对体外培养新生大鼠颅骨成骨细胞的影响.中国新药与临床药理,2007,18(1)：32-34.
13.张军,马锡金摘译.补骨脂种子提取物的粗组分对骨钙化的影响(英).国外医学·中医中药分册,1997,19(1)：55)。
14.蒙海燕；曲晓波；李娜等.鹿茸及鹿角胶对去卵巢大鼠骨质疏松的影响.中药材.2009,(2)：179-182
15.廖悦华,梁琼,王卓等.中药骨碎补对去睾丸骨质疏松症动物模型的影响.中国骨质疏松杂志,2007,(4)：277-280
16.刘稼聚类分析在中医药研究中的应用及意义中医药学刊2004；22(5)：927-928
2.焦树德强直性脊柱炎的治疗经验河北中医2004年第26卷第10期725-726.
3.项红焦树德治疗强直性脊柱炎的临床经验北京中医2003,23(3)：142-144.
4.王北.王为兰教授治疗强直性脊柱炎的临床经验.北京中医药大学学报(中医临床版)2008年9月,15(5)：23-24.
5.王鑫.房定亚运用补肾疏督法治疗强直性脊柱炎探微.上海中医药杂志2008年第42卷第7期1-2.
6.邓长财,鞠中斌.张鸣鹤治疗活动期强直性脊柱炎经验探讨.山东中医药大学学报2006,30(5)：372-373.
7.顾军花、茅建春、周时高等陈湘君运用扶正法治疗强直性脊柱炎经验撷菁土海中医药杂志2008年第42卷第3期12-13.
8.林昌松,刘晓玲,关彤等陈纪藩教授治疗强直性脊柱炎经验新中医2001年2月第33卷第2期10-11.
9.方路,许东云 舒尚义老师治疗强直性脊柱炎经验举要云南中医中药杂志2004年第29卷第6期1-2.
10.张梅红、谷万里、于秀梅等谷越涛治疗强直性脊柱炎经验 四川中医2004年第22卷第8期5-7.
11.韩善夯金实教授治疗强直性脊柱炎经验 四川中医2005,23(1)：1-2.
1.邱德文,吴元黔,熊兴平等.中国当代名老中医药专家学术经验的整理研究(上)贵阳中医学院学报,2000,22(3)；52.
2.王映辉,张润顺,吴洁等,名老中医经验传承研究模式探索.中国中医基础医学杂志,2008,14(6)：417-419.
3.邓铁涛.怎样正确认识中医.上海中医药杂志,2001,35(1)：4.
4.邓铁涛。中医成才之路。新中医2000；32(11)：11.
5.陆晴友,吴岳嵩.人工智能专家系统及其在骨科领域中的应用.中国矫形外科杂志,2005,13(1)：141-143.
6.刘保延.数字中医药与中医药的跨越式发展[J].中国中医药信息杂志,2002(08)：3-4.
7.张华,刘保延,田从豁等.“人机结合、以人为主”的名老中医经验整理研究方法.中医研究.2007,20(2)：4-6.
8.陈涛,李克乾,陈茂华,等.4400例当代名医医案的舌象分布频数分析[J].辽宁中医杂志,2007,34(9)：1217.
9.张华东,赵冰,王映辉等.谢海洲“治痹三要四宜”学术思想之信息化研究.湖北中医杂志.2008,30(11)：4-7.
10.张启明,王永炎,张志斌等.外感病因中证候要素的提取[J].山东中医药大学学报,2005,29(5)：339-341.
11.谢元华,张京春,蒋跃绒等.陈可冀辨治高血压病医案的数据挖掘分析[J].中西医结合心脑血管病杂志,2008,6(2)：135.
12.张京春,谢元华.陈可冀院士辨治冠心病医案的数据挖掘[J].世界中西医结合杂志,2008,3(1)：4.
13.叶放,陶帅,徐吉敏等.周仲瑛教授应用犀角地黄汤临床经验要素数据挖掘分析.中华中医药杂志(原中国医药学报).2010,25(10)：1577-1579.
14.田琳,闫英杰,朱建贵等.整理挖掘名老中医诊疗眩晕病辨证思维模式的思路与探讨.中国中医基础医学杂志,2006,12(8)：618-622.
15.吴荣,王阶,任延革等.基于数据挖掘的名老中医冠心病诊疗规律研究.中华中医药学刊.2008,26(12)：2581-2583.
16.王映辉,姜在旸,刘保延等.基于信息和数据挖掘技术的名老中医临床诊疗经验研究思路[J].世界科学技术·中医药现代化,2005,7(1)：98-105.
17.谭定英,老膺荣,古求知等.面向循证传承的名老中医个人医案数据挖掘研究思路初探.新中医,2011,43(8)：162-164.
1.刘吉人.中国医学大成·卷三·伏邪新书[M].长沙：岳麓书社,1990.777.
2.尤在泾.尤在泾医学全书·医学读书记[M].北京：中国中医药出版社,2002：344
3.李顺保.温病学全书[M].北京：学苑出版社,2002.352,518,20,522.519
4.尤在泾.中国医学大成·卷四·金匮翼·卷六[M].长沙：岳麓书社,1990.304.
5.蒋明,张奉春主编.风湿病诊断与诊断评析.上海：上海科学技术出版社.2004年9月第一版,166
6.胡荫奇,唐先平主编.简明中西医结合风湿病学.北京：科学技术文献出版社.2009年2月第一版,62
7.绵解对去卵巢大鼠骨代谢改变的干预作用。中国中药杂志>2007年18期
8.李中华；赵晓芳半枝莲水煎液对肝纤维化模型大鼠间质胶原和TGF-β_1的影响山东中医杂志2010年1期41-43
9.蒋明,朱立平,林孝义主编风湿病学北京：科学出版社1995年4月465
10.杨珺,邹全明.鳖甲超微细粉增加大鼠骨密度的研究[J].食品科学,2001,22(3)：86-88.
11.王全权,陈海林,宗芳,等.补骨脂复方制剂干预绝经后骨质疏松症的作用.中国临床康复,2006,35(10)：145-148。
12.杨荣平,寿清耀,涂永勤,等.补骨脂提取物对体外培养新生大鼠颅骨成骨细胞的影响.中国新药与临床药理,2007,18(1)：32-34.
13.张军,马锡金摘译.补骨脂种子提取物的粗组分对骨钙化的影响(英).国外医学·中医中药分册,1997,19(1)：55)。
14.蒙海燕；曲晓波；李娜等.鹿茸及鹿角胶对去卵巢大鼠骨质疏松的影响.中药材.2009,(2)：179-182
15.廖悦华,梁琼,王卓等.中药骨碎补对去睾丸骨质疏松症动物模型的影响.中国骨质疏松杂志,2007,(4)：277-280
16.刘稼聚类分析在中医药研究中的应用及意义中医药学刊2004；22(5)：927-928