除湿胃苓汤加减方治疗脾虚湿蕴型亚急性湿疹的临床疗效观察
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摘要
目的：
比较除湿胃苓汤加减方联合西药和单纯西药治疗脾虚湿蕴型亚急性湿疹的临床疗效和安全性。拟通过课题研究找到更安全、更有效的治疗湿疹的方法,在临床医疗上能够起到一定的指导作用。
方法：
所选54例患者均来源于武汉市第一医院皮肤科湿疹专科门诊和病房,符合湿疹诊断标准,通过中医辨证属于脾虚湿蕴证。随机分为治疗组和对照组,治疗组30例,对照组24例。两组在性别、年龄、病程、湿疹面积及严重度指数(EASI)评分上无显著性差异(P>0.05),具有可比性。
治疗组口服除湿胃苓汤加减方,1剂/d,分早晚两次服,静脉注射复方甘草酸苷,每次80mg(以甘草酸苷计)加入5%葡萄糖注射液或注射用生理盐水250ml中静脉滴注,1次/d,并口服抗组胺药氯苯那敏片4 mg/次,3次/d,疗程为2w,外用本院制剂复方醋酸曲安奈德软膏或复方氧化锌搽剂。对照组静脉注射复方甘草酸苷并口服抗组胺药氯苯那敏片,用法同治疗组,外用药同治疗组。
通过临床有效率、自觉症状瘙痒治疗前后的变化、有效率、不良反应的发生率、复发率方面来进行评定,进行统计学处理,观察除湿胃苓汤治疗脾虚湿蕴型亚急性湿疹的有效性、安全性。
结果：
1.有效率比较：治疗组痊愈16例,显效10例,好转3例,无效1例,有效率86.67%；对照组痊愈7例,显效8例,好转8例,无效1例,有效率62.50%。治疗组有效率明显高于对照组。两组有效率比较经x2检验,P<0.05,差异有统计学意义,治疗组疗效优于对照组。
2.瘙痒评分比较：两组间治疗前比较P>0.05,无显著性差异；两组治疗1周后组内比较P<0.01,具有显著性差异,说明治疗组与对照组治疗前后瘙痒程度均明显减轻；治疗2周后治疗组与对照组比较P<0.05,有显著性差异,说明在瘙痒程度的改善情况方面治疗组优于对照组。
3.不良反应发生率比较：治疗组发生4例,不良反应发生率13.33%,对照组发生2例,不良反应发生率8.33%,两组比较经x2检验,P>0.05,差异无统计学意义。
4.复发率比较：对治疗组和对照组痊愈患者在完成治疗后进行2周的随访,治疗组16例,复发2例,复发率12.50%,对照组7例,复发2例,复发率28.57%,两组复发率比较：P>0.05,差异无统计学意义。
结论：
通过本课题的临床观察表明,在西医常规治疗的基础上联用除湿胃苓汤加减方治疗脾虚湿蕴型亚急性湿疹,患者的皮损状况、瘙痒程度等指标得到更好改善,临床应用证实有效、安全,值得推广应用。
Objective:
Comparison of clinical efficacy and safety of modification of Chushi Weiling Decoction combined with western medicine and western medicine alone cureing Spleen wet Yun subacute eczema. To be adopted by the research to find safer, more effective method of treatment of eczema, to be able to play a guiding role in the clinical. Method:54 patients were selected from Eczema Specialist Outpatient Clinics and wards, Wuhan First Hospital. All patients were met the diagnostic criteria for eczema and belonged of Spleen wet Yun card through the TCM. Patients were randomly divided into treatment group and control group, treatment group,30 cases, in the control group 24 cases. The two groups in gender, age, course of disease, eczema area and severity index (EASI) score was no significant difference (P>0.05), comparable. Treatment group:
Oral modification of Chushi Weiling Decoction, day 1, divided into morning and evening to take; SNMC ived,80mg per-use (With the calculation of the amount of Glycyrrhizin), in 250ml of 5% glucose injection or Saline injection,1 time/d; chlorpheniramine oral tablets 4 mg/time,3 times/d, Topical triamcinolone acetonide acetate ointment compound and compound zinc oxide liniment.
Control group:SNMC ived while chlorpheniramine oral chlorpheniramine tablets tablets, usage with the treatment group and for external use with the treatment group. Treatment for the 2w.
Through effective rate, change of itching symptom before and after treatment, efficiency and the incidence of adverse reactions, relapse rate assessed for statistical analysis to observe the effectiveness, safety.
Rusults:
1. Effective rate:the treatment group cured 16 cases, effective in 10 cases, improvement in 3 cases, ineffective in 1 case, efficiency rate 86.67%; The control group healed in 7 cases, markedly effective in 8 cases improved in 8 cases, ineffective in 1 case, efficiency rate 62.50%. The treatment group were more efficient than that in control group significantly. Comparing the efficiency of two groups by theχ2test, P<0.05, statistically significant differences; the treatment group were more effective than the control group.
2. Comparison of pruritus score:comparison of the scores between the two groups before treatment, (P>0.05),no significant difference;the comparison in the group of the each group after 1 week treatment (P<0.01),the difference was significant, noteing the itching degree of treatment group and control group reduced significantly after treatment; After 2 weeks of treatment the treatment group compared with control group(P<0.05),there was significant difference, indicating the treatment group was better than the control group in the degree of itching improvement.
3. The incidence of adverse reactions:the treatment group occurred in 4 cases, the incidence of 13.33%; the control group occurred in 2 cases, the incidence of 8.33%. Comparing the two groups by theχ2test (P>0.05), the difference was not statistically significant.
4. Relapse rate:
Follow-up of patients cured in treatment group and control group 2 weeks after the completion of treatment. The treatment group 16 cases,2 cases of recurrence, the recurrence rate of 12.50%, control group,7 cases,2 cases of recurrence, the recurrence rate of 28.57%. Relapse rate compared between two groups:P>0.05, the difference was not statistically significant.
Conclusion:
Clinical observation of the subject shoued that in the treatment of Spleen wet Yun subacute eczema on the basis of conventional treatment combined with modification of Chushi Weiling Decoction, Status of patients with skin lesions, itching indicated of the degree of improvement to be better. Clinical studies proved to be effective, safe and worthy of popularization.
比较除湿胃苓汤加减方联合西药和单纯西药治疗脾虚湿蕴型亚急性湿疹的临床疗效和安全性。拟通过课题研究找到更安全、更有效的治疗湿疹的方法,在临床医疗上能够起到一定的指导作用。
方法：
所选54例患者均来源于武汉市第一医院皮肤科湿疹专科门诊和病房,符合湿疹诊断标准,通过中医辨证属于脾虚湿蕴证。随机分为治疗组和对照组,治疗组30例,对照组24例。两组在性别、年龄、病程、湿疹面积及严重度指数(EASI)评分上无显著性差异(P>0.05),具有可比性。
治疗组口服除湿胃苓汤加减方,1剂/d,分早晚两次服,静脉注射复方甘草酸苷,每次80mg(以甘草酸苷计)加入5%葡萄糖注射液或注射用生理盐水250ml中静脉滴注,1次/d,并口服抗组胺药氯苯那敏片4 mg/次,3次/d,疗程为2w,外用本院制剂复方醋酸曲安奈德软膏或复方氧化锌搽剂。对照组静脉注射复方甘草酸苷并口服抗组胺药氯苯那敏片,用法同治疗组,外用药同治疗组。
通过临床有效率、自觉症状瘙痒治疗前后的变化、有效率、不良反应的发生率、复发率方面来进行评定,进行统计学处理,观察除湿胃苓汤治疗脾虚湿蕴型亚急性湿疹的有效性、安全性。
结果：
1.有效率比较：治疗组痊愈16例,显效10例,好转3例,无效1例,有效率86.67%；对照组痊愈7例,显效8例,好转8例,无效1例,有效率62.50%。治疗组有效率明显高于对照组。两组有效率比较经x2检验,P<0.05,差异有统计学意义,治疗组疗效优于对照组。
2.瘙痒评分比较：两组间治疗前比较P>0.05,无显著性差异；两组治疗1周后组内比较P<0.01,具有显著性差异,说明治疗组与对照组治疗前后瘙痒程度均明显减轻；治疗2周后治疗组与对照组比较P<0.05,有显著性差异,说明在瘙痒程度的改善情况方面治疗组优于对照组。
3.不良反应发生率比较：治疗组发生4例,不良反应发生率13.33%,对照组发生2例,不良反应发生率8.33%,两组比较经x2检验,P>0.05,差异无统计学意义。
4.复发率比较：对治疗组和对照组痊愈患者在完成治疗后进行2周的随访,治疗组16例,复发2例,复发率12.50%,对照组7例,复发2例,复发率28.57%,两组复发率比较：P>0.05,差异无统计学意义。
结论：
通过本课题的临床观察表明,在西医常规治疗的基础上联用除湿胃苓汤加减方治疗脾虚湿蕴型亚急性湿疹,患者的皮损状况、瘙痒程度等指标得到更好改善,临床应用证实有效、安全,值得推广应用。
Objective:
Comparison of clinical efficacy and safety of modification of Chushi Weiling Decoction combined with western medicine and western medicine alone cureing Spleen wet Yun subacute eczema. To be adopted by the research to find safer, more effective method of treatment of eczema, to be able to play a guiding role in the clinical. Method:54 patients were selected from Eczema Specialist Outpatient Clinics and wards, Wuhan First Hospital. All patients were met the diagnostic criteria for eczema and belonged of Spleen wet Yun card through the TCM. Patients were randomly divided into treatment group and control group, treatment group,30 cases, in the control group 24 cases. The two groups in gender, age, course of disease, eczema area and severity index (EASI) score was no significant difference (P>0.05), comparable. Treatment group:
Oral modification of Chushi Weiling Decoction, day 1, divided into morning and evening to take; SNMC ived,80mg per-use (With the calculation of the amount of Glycyrrhizin), in 250ml of 5% glucose injection or Saline injection,1 time/d; chlorpheniramine oral tablets 4 mg/time,3 times/d, Topical triamcinolone acetonide acetate ointment compound and compound zinc oxide liniment.
Control group:SNMC ived while chlorpheniramine oral chlorpheniramine tablets tablets, usage with the treatment group and for external use with the treatment group. Treatment for the 2w.
Through effective rate, change of itching symptom before and after treatment, efficiency and the incidence of adverse reactions, relapse rate assessed for statistical analysis to observe the effectiveness, safety.
Rusults:
1. Effective rate:the treatment group cured 16 cases, effective in 10 cases, improvement in 3 cases, ineffective in 1 case, efficiency rate 86.67%; The control group healed in 7 cases, markedly effective in 8 cases improved in 8 cases, ineffective in 1 case, efficiency rate 62.50%. The treatment group were more efficient than that in control group significantly. Comparing the efficiency of two groups by theχ2test, P<0.05, statistically significant differences; the treatment group were more effective than the control group.
2. Comparison of pruritus score:comparison of the scores between the two groups before treatment, (P>0.05),no significant difference;the comparison in the group of the each group after 1 week treatment (P<0.01),the difference was significant, noteing the itching degree of treatment group and control group reduced significantly after treatment; After 2 weeks of treatment the treatment group compared with control group(P<0.05),there was significant difference, indicating the treatment group was better than the control group in the degree of itching improvement.
3. The incidence of adverse reactions:the treatment group occurred in 4 cases, the incidence of 13.33%; the control group occurred in 2 cases, the incidence of 8.33%. Comparing the two groups by theχ2test (P>0.05), the difference was not statistically significant.
4. Relapse rate:
Follow-up of patients cured in treatment group and control group 2 weeks after the completion of treatment. The treatment group 16 cases,2 cases of recurrence, the recurrence rate of 12.50%, control group,7 cases,2 cases of recurrence, the recurrence rate of 28.57%. Relapse rate compared between two groups:P>0.05, the difference was not statistically significant.
Conclusion:
Clinical observation of the subject shoued that in the treatment of Spleen wet Yun subacute eczema on the basis of conventional treatment combined with modification of Chushi Weiling Decoction, Status of patients with skin lesions, itching indicated of the degree of improvement to be better. Clinical studies proved to be effective, safe and worthy of popularization.
引文
[1]国家中医药管理局.中医病证诊断疗效标准[S].南京：南京大学出版社,1994：137
[2]赵辨.临床皮肤病学,第3版.南京：江苏科学技术出版社,2001,604
[3]Hanif in JM, Thurston M, Omoto M, et al. The eczema erea and severity index(EASI):assessment of reliability in atopic dermatitis. EASI Evaluator Grop[J].Exp Dermatol,2001,10(1):1-8
[4]李林峰.接触性皮炎与皮肤变态反应[M].第2版.北京：北京大学医学出版社,2003：79
[5]张洁,刘艳,杨蓉娅.接触性皮炎和湿疹斑贴试验400例分析[J].中国误诊学杂志,2008,8(3)：630-631
[6]石岩,李文政,普雄明.158例皮炎湿疹斑贴试验结果分析[J].新疆医学,2008,38,138-139
[7]王德旭,张炜,苏东宝,等.皮炎湿疹致病因素分析[J].中国麻风皮肤病杂志,2008,24(5)：396-397
[8]吴蓓玲,孙洁,余土根,等.462例慢性湿疹患者斑贴试验分析[J].检验医学与临床,2009,6(1)：40-41
[9]张利,赖蓉,尹洁.湿疹患者食物过敏原特异性IgG检测及意义[J].四川医学,2009,30(2)：256-257
[10]林颖,陈达灿.变态反应性疾病发病相关因素的研究进展[J].中国中西医结合皮肤性病学杂志,2005,4(1)：60-63
[11]王学艳,杨雪飞,张明,等.过敏性皮肤病与食物过敏原特异性免疫球蛋白G的临床分析[J].南方医科大学学报,2006,26(1)：15-21
[12]袁茵,郑苏蓉,张炜.慢性湿疹患者的心理健康水平测查分析[J].健康心理学杂志,2004,12(1)：22-23
[13]程宇琪,许秀峰,徐健,等.影响慢性皮炎、湿疹患者心理健康状况及心理社会因素的研究[J].昆明医学院学报,2008,29(5)：170-175
[14]Hashirn M. Okumura M The relationship betweeen the psy-chological and immunological state in patients with atopic dermatitis [J].Dermatol Science,1998,16(3):231
[15]刘瓦利.湿疹类皮肤病中西医结合治疗[J].北京：人们卫生出版社,2004：22
[16]Bahna SL. Food allergy and intolerance [J]. Pediatr Ann,2006, 35 (10):690,692-693
[17]Wollenberg A, et al. Atopic dermatitis:pathogenetic mechanisms .Clin Exp Dermatol.2000,25:530-534
[18]陈丽芳,李林峰.微生物与特应性皮炎.国外医学皮肤性病分册,2001,27：265-267
[19]王鹰,刁庆春.特异性皮炎病因及发病机制的研外医学,皮肤性病学分册,2002,28(3)：154
[20]Baldacci S,Modena P, Carrozzi L, et al. Skin prick test reactivity to common aeroallergens in relation to total IgE, respiratory symptoms, and smoking in a general population sample of northern Italyv[J].Allergy,1996,51 (3):149-156
[21]北京中医医院.赵炳南临床经验集.北京：人民卫生出版社,1975.130-144
[22]朱仁康.湿疹证治.中医杂志,1986,27(8)：(总570)
[23]中医研究院.岳美中医案集.北京：人们卫生出版社,1978：144-145
[24]秦万章.湿疹证治[J].中医杂志,1986,27(8)：571
[25]张洪恩.周鸣岐老中医治疗慢性湿疹的经验[J].辽宁中医杂志,1985,(1)：14-15
[26]马绍尧.适用中医皮肤病学.上海：上海中医药大学出版社,1995：231-235
[27]徐恩波.浅谈湿疹证治[J].浙江中医学院学报,1995,19(6)：8
[28]翟幸.中医辨证治疗湿疹85例[J].中医杂志,1995,36(10)：615
[29]张健臣.速效湿疹灵的研制与临床应用[J].中药材1995,18(12)：641
[30]余恒先,施梓桥.以扶正为主治疗慢性湿疹经验[J].辽宁中医杂志,1997,24 (11)：483
[31]白彦平.湿疹的中医治疗与研究现状[J].北京中医,1999,18(6)：50
[32]郭盾,张友仁.胃苓汤加减治疗手部慢性湿疹120例[J].中国中西医结合杂志,2000,20(4)：301
[33]向阳,张毅.湿疹内服方用药规律分析[J].云南中医中药杂志,2008,29(1)：21-23
[34]廖建芬,李烜,吴波.中西医结合治疗湿疹60例观察[J].实用中医药杂志,2009,25(4)：232
[35]杨凡,甘海芳,艾儒棣.艾儒棣教授治疗湿疹经验[J].四川中医,2009,27(2)：4-5
[36]白彦萍.湿疹的中医诊治[J].中国中西医结合皮肤性病学杂志,2009年,8(4)：259-261
[37]李健波,周锡生,黄耀创.复方甘草酸苷注射液治疗湿疹的疗效观察[J].岭南皮肤性病科杂志,2009,16(2)：113-114
[38]金顺福,李莲花.复方甘草酸苷治疗急性湿疹68例分析[J].吉林医学,2008,29(5)：381-382
[39]周小勇,袁勇谋,孙庆云,等.复方甘草酸苷注射液治疗泛发性湿疹临床疗效评价[J].中国皮肤性病学杂志,2006,20(2)：124-125
[40]Shiki Y, ShiraiK,Saito Y. Effect of glycyrrhizin on lysis of hepato-cyte membranes induced by anti-liver cell membrane antibody. Gas-troenterol Hepatol,1992,7:12
[41]TeruakiA. Inhititory effects ofglycyrrhetic acid derivatives n11 β-and3α-hydroxysteroid dehydrogenases of rat liver. CHEMICAL AND PHARMACEUTICAL BULLETIN,1992,40(11):3021
[42]Shiro Iino, Toshiro Tango, TakashiMatsushima,et a. 1Therapeutic effects of stronger neo-minophagerC at diffenet doses on chronic hep-atitis and liver cirrhosis. HepatologyResearch,2001,19:31
[43]韩冰雪.复方甘草酸苷联合中药治疗湿疹疗效观察[J].赤峰学院学报,2009,25(4)：51-53
[44]金顺福,李莲花.复方甘草酸苷治疗急性湿疹68例分析[J].吉林医学,2008,29(5)：381-382
[45]李健波,周锡生,黄耀创.复方甘草酸苷注射液治疗湿疹的疗效观察[J].岭南皮肤性病科杂志,2009,16(2)：113-114
[46]刘淑芳.美能与氯雷他啶联合治疗亚急性湿疹的疗效观察[J].青海医药杂志,2009,39(4)：24
[47]陈办成,姚思敏,朱亦男,等.咪唑斯汀联合复方甘草酸苷治疗慢性湿疹疗效观察[J].2009,5：84
[48]白彦萍.湿疹的中医诊治[J].中国中西医结合皮肤性病学杂志,2009,8(4)：259-261
[49]李德龙,耿春梅.除湿胃苓汤治验3例[J].山西中医,2006,22(3)：35
[50]黄其清.除湿胃苓汤加减治疗亚急性湿疹26例临床观察[J].海南医学,2001,12(7)：67-68
[51]陈希明.除湿胃苓汤加减治疗亚急性湿疹临床观察[J].中医中药,1999,13(4)：236-237
[52]吴春燕,李永海.除湿胃苓汤治愈掌跖脓疱病1例[J].北京中医2007,26(8)：520
[53]于藤,孙龙,王欣.健脾化湿治疗天疱疮[J].山东中医杂志,2002,21(7)：439-44
[1]赵辨.临床皮肤病学,第3版.南京：江苏科学技术出版社,2001,604
[2]栾天庆.中医药治疗亚急性湿疹临床观察[J].现代中西医结合杂志,2008,17(33)：5168-5169
[3]邴雅珺,姚明.除湿饮治疗老年湿热内蕴型亚急性湿疹31例临床研究[J].甘肃中医,2008,21(11)：30-31
[4]陈希明.除湿胃苓汤加减治疗亚急性湿疹临床观察[J].中国皮肤性病学杂志,1999,13(4)：236-237
[5]张军弼.加味石兰草方治疗热盛型亚急性湿疹68例临床观察[J].四川中医,2005,23(12)：87-88
[6]朱霞,杨志波.凉血消风散治疗亚急性湿疹60例临床观察[J].中医药导报,2005,11(9)：33-34
[7]丁文,王玉玺.湿疹汤加减治疗亚急性湿疹的疗效观察[J].中医药学报,2008,36(3)：52-54
[8]任少杰.二黄茯苓汤治疗亚急性湿疹临床观察[J].中医药临床杂志,2008,20(4)：392-393
[9]邴雅珺,姚明.除湿饮治疗老年湿热内蕴型亚急性湿疹31例临床研究[J].甘肃中医,2008,21(11)：30-31
[10]郭继华,张皖敏.自拟湿疹方为主治疗急性湿疹85例分析[J].安徽中医临床杂志,2002,11(1)：24-25
[11]涂彩霞,刘芳,李敬,等.复方茯苓汤治疗湿疹582例临床观察及实验研究[J].中国中西医结合皮肤性病学杂志,2002,1(1)：13-15
[12]施康能.银蛇汤为主治疗亚急性湿疹62例[J].江西中医药,2001,32(5)：52
[13]苏惜香,李森真,蔡怿,等.中西药结合治疗接触性皮炎,急性、亚急性湿疹的疗效观察[J].中国医药导报,2008,5(2)：88
[14]李晓睿,李咏梅.冰黄肤乐软膏治疗亚急性湿疹103例临床疗效观察 [J].中国中西医结合皮肤性病学杂志,2007,6(4)：242-243
[15]刘水萍,黄小兰,范春颖.中药外用联合西替利嗪和丁酸氢化可的松软膏治疗湿疹疗效观察[J].岭南皮肤性病科杂志,2008,15(3)：161-162
[16]刘涛,张燕萍.中药湿敷治疗急性、亚急性湿疹134例[J].宁夏医学杂志,1997,19(3)：183
[17]商燕畦,雷翠云.中药离子喷雾治疗亚急性湿疹效果观察[J].护理学杂志,2005,20(10)：45-46
[18]王延峰,李兰云,王文庆.湿疹油浸剂治疗亚急性肛门湿疹76例临床观察[J].河北中医,2009,31(1)：40-41
[19]张春香,刘家玉,王亚平.湿敷Ⅱ号液联合派瑞松霜治疗足部亚急性湿疹临床观察[J].中国麻风皮肤病病杂,2005,21,(5)：360
[20]高宜云,许月清.如意金黄散合尤卓尔治疗亚急性湿疹120例[J].浙江中医杂志,2004,39(11)：484
[21]邹继英.除湿止痒洗液治疗亚急性湿疹78例疗效观察[J].中医药临床杂,2008,20(4)：839-840
[22]黄霞,黄忠田.湿疹治验[J].光明中医,2008,2(1)：88-89
[23]马洪明,张新洁,乔嘉伟.自拟湿疹煎治疗急性、亚急性湿疹98例临床观察[J].中国麻风皮肤病杂志,2000,16(3)：147
[24]郭继华,张皖敏.自拟湿疹方为主治疗急性亚急性湿疹85例分析[J].安徽中医临床杂志,2002,14(1)：24-25
[25]黄尧洲.内外合治湿疹经验[J].中国中西医结合杂志,2008,28(8)：681
邢建军,宋玲娟,段逸群,等.丘疹性梅毒疹误诊1例.中国中西医结合皮肤性病学杂志.(待刊)
[2]赵辨.临床皮肤病学,第3版.南京：江苏科学技术出版社,2001,604
[3]Hanif in JM, Thurston M, Omoto M, et al. The eczema erea and severity index(EASI):assessment of reliability in atopic dermatitis. EASI Evaluator Grop[J].Exp Dermatol,2001,10(1):1-8
[4]李林峰.接触性皮炎与皮肤变态反应[M].第2版.北京：北京大学医学出版社,2003：79
[5]张洁,刘艳,杨蓉娅.接触性皮炎和湿疹斑贴试验400例分析[J].中国误诊学杂志,2008,8(3)：630-631
[6]石岩,李文政,普雄明.158例皮炎湿疹斑贴试验结果分析[J].新疆医学,2008,38,138-139
[7]王德旭,张炜,苏东宝,等.皮炎湿疹致病因素分析[J].中国麻风皮肤病杂志,2008,24(5)：396-397
[8]吴蓓玲,孙洁,余土根,等.462例慢性湿疹患者斑贴试验分析[J].检验医学与临床,2009,6(1)：40-41
[9]张利,赖蓉,尹洁.湿疹患者食物过敏原特异性IgG检测及意义[J].四川医学,2009,30(2)：256-257
[10]林颖,陈达灿.变态反应性疾病发病相关因素的研究进展[J].中国中西医结合皮肤性病学杂志,2005,4(1)：60-63
[11]王学艳,杨雪飞,张明,等.过敏性皮肤病与食物过敏原特异性免疫球蛋白G的临床分析[J].南方医科大学学报,2006,26(1)：15-21
[12]袁茵,郑苏蓉,张炜.慢性湿疹患者的心理健康水平测查分析[J].健康心理学杂志,2004,12(1)：22-23
[13]程宇琪,许秀峰,徐健,等.影响慢性皮炎、湿疹患者心理健康状况及心理社会因素的研究[J].昆明医学院学报,2008,29(5)：170-175
[14]Hashirn M. Okumura M The relationship betweeen the psy-chological and immunological state in patients with atopic dermatitis [J].Dermatol Science,1998,16(3):231
[15]刘瓦利.湿疹类皮肤病中西医结合治疗[J].北京：人们卫生出版社,2004：22
[16]Bahna SL. Food allergy and intolerance [J]. Pediatr Ann,2006, 35 (10):690,692-693
[17]Wollenberg A, et al. Atopic dermatitis:pathogenetic mechanisms .Clin Exp Dermatol.2000,25:530-534
[18]陈丽芳,李林峰.微生物与特应性皮炎.国外医学皮肤性病分册,2001,27：265-267
[19]王鹰,刁庆春.特异性皮炎病因及发病机制的研外医学,皮肤性病学分册,2002,28(3)：154
[20]Baldacci S,Modena P, Carrozzi L, et al. Skin prick test reactivity to common aeroallergens in relation to total IgE, respiratory symptoms, and smoking in a general population sample of northern Italyv[J].Allergy,1996,51 (3):149-156
[21]北京中医医院.赵炳南临床经验集.北京：人民卫生出版社,1975.130-144
[22]朱仁康.湿疹证治.中医杂志,1986,27(8)：(总570)
[23]中医研究院.岳美中医案集.北京：人们卫生出版社,1978：144-145
[24]秦万章.湿疹证治[J].中医杂志,1986,27(8)：571
[25]张洪恩.周鸣岐老中医治疗慢性湿疹的经验[J].辽宁中医杂志,1985,(1)：14-15
[26]马绍尧.适用中医皮肤病学.上海：上海中医药大学出版社,1995：231-235
[27]徐恩波.浅谈湿疹证治[J].浙江中医学院学报,1995,19(6)：8
[28]翟幸.中医辨证治疗湿疹85例[J].中医杂志,1995,36(10)：615
[29]张健臣.速效湿疹灵的研制与临床应用[J].中药材1995,18(12)：641
[30]余恒先,施梓桥.以扶正为主治疗慢性湿疹经验[J].辽宁中医杂志,1997,24 (11)：483
[31]白彦平.湿疹的中医治疗与研究现状[J].北京中医,1999,18(6)：50
[32]郭盾,张友仁.胃苓汤加减治疗手部慢性湿疹120例[J].中国中西医结合杂志,2000,20(4)：301
[33]向阳,张毅.湿疹内服方用药规律分析[J].云南中医中药杂志,2008,29(1)：21-23
[34]廖建芬,李烜,吴波.中西医结合治疗湿疹60例观察[J].实用中医药杂志,2009,25(4)：232
[35]杨凡,甘海芳,艾儒棣.艾儒棣教授治疗湿疹经验[J].四川中医,2009,27(2)：4-5
[36]白彦萍.湿疹的中医诊治[J].中国中西医结合皮肤性病学杂志,2009年,8(4)：259-261
[37]李健波,周锡生,黄耀创.复方甘草酸苷注射液治疗湿疹的疗效观察[J].岭南皮肤性病科杂志,2009,16(2)：113-114
[38]金顺福,李莲花.复方甘草酸苷治疗急性湿疹68例分析[J].吉林医学,2008,29(5)：381-382
[39]周小勇,袁勇谋,孙庆云,等.复方甘草酸苷注射液治疗泛发性湿疹临床疗效评价[J].中国皮肤性病学杂志,2006,20(2)：124-125
[40]Shiki Y, ShiraiK,Saito Y. Effect of glycyrrhizin on lysis of hepato-cyte membranes induced by anti-liver cell membrane antibody. Gas-troenterol Hepatol,1992,7:12
[41]TeruakiA. Inhititory effects ofglycyrrhetic acid derivatives n11 β-and3α-hydroxysteroid dehydrogenases of rat liver. CHEMICAL AND PHARMACEUTICAL BULLETIN,1992,40(11):3021
[42]Shiro Iino, Toshiro Tango, TakashiMatsushima,et a. 1Therapeutic effects of stronger neo-minophagerC at diffenet doses on chronic hep-atitis and liver cirrhosis. HepatologyResearch,2001,19:31
[43]韩冰雪.复方甘草酸苷联合中药治疗湿疹疗效观察[J].赤峰学院学报,2009,25(4)：51-53
[44]金顺福,李莲花.复方甘草酸苷治疗急性湿疹68例分析[J].吉林医学,2008,29(5)：381-382
[45]李健波,周锡生,黄耀创.复方甘草酸苷注射液治疗湿疹的疗效观察[J].岭南皮肤性病科杂志,2009,16(2)：113-114
[46]刘淑芳.美能与氯雷他啶联合治疗亚急性湿疹的疗效观察[J].青海医药杂志,2009,39(4)：24
[47]陈办成,姚思敏,朱亦男,等.咪唑斯汀联合复方甘草酸苷治疗慢性湿疹疗效观察[J].2009,5：84
[48]白彦萍.湿疹的中医诊治[J].中国中西医结合皮肤性病学杂志,2009,8(4)：259-261
[49]李德龙,耿春梅.除湿胃苓汤治验3例[J].山西中医,2006,22(3)：35
[50]黄其清.除湿胃苓汤加减治疗亚急性湿疹26例临床观察[J].海南医学,2001,12(7)：67-68
[51]陈希明.除湿胃苓汤加减治疗亚急性湿疹临床观察[J].中医中药,1999,13(4)：236-237
[52]吴春燕,李永海.除湿胃苓汤治愈掌跖脓疱病1例[J].北京中医2007,26(8)：520
[53]于藤,孙龙,王欣.健脾化湿治疗天疱疮[J].山东中医杂志,2002,21(7)：439-44
[1]赵辨.临床皮肤病学,第3版.南京：江苏科学技术出版社,2001,604
[2]栾天庆.中医药治疗亚急性湿疹临床观察[J].现代中西医结合杂志,2008,17(33)：5168-5169
[3]邴雅珺,姚明.除湿饮治疗老年湿热内蕴型亚急性湿疹31例临床研究[J].甘肃中医,2008,21(11)：30-31
[4]陈希明.除湿胃苓汤加减治疗亚急性湿疹临床观察[J].中国皮肤性病学杂志,1999,13(4)：236-237
[5]张军弼.加味石兰草方治疗热盛型亚急性湿疹68例临床观察[J].四川中医,2005,23(12)：87-88
[6]朱霞,杨志波.凉血消风散治疗亚急性湿疹60例临床观察[J].中医药导报,2005,11(9)：33-34
[7]丁文,王玉玺.湿疹汤加减治疗亚急性湿疹的疗效观察[J].中医药学报,2008,36(3)：52-54
[8]任少杰.二黄茯苓汤治疗亚急性湿疹临床观察[J].中医药临床杂志,2008,20(4)：392-393
[9]邴雅珺,姚明.除湿饮治疗老年湿热内蕴型亚急性湿疹31例临床研究[J].甘肃中医,2008,21(11)：30-31
[10]郭继华,张皖敏.自拟湿疹方为主治疗急性湿疹85例分析[J].安徽中医临床杂志,2002,11(1)：24-25
[11]涂彩霞,刘芳,李敬,等.复方茯苓汤治疗湿疹582例临床观察及实验研究[J].中国中西医结合皮肤性病学杂志,2002,1(1)：13-15
[12]施康能.银蛇汤为主治疗亚急性湿疹62例[J].江西中医药,2001,32(5)：52
[13]苏惜香,李森真,蔡怿,等.中西药结合治疗接触性皮炎,急性、亚急性湿疹的疗效观察[J].中国医药导报,2008,5(2)：88
[14]李晓睿,李咏梅.冰黄肤乐软膏治疗亚急性湿疹103例临床疗效观察 [J].中国中西医结合皮肤性病学杂志,2007,6(4)：242-243
[15]刘水萍,黄小兰,范春颖.中药外用联合西替利嗪和丁酸氢化可的松软膏治疗湿疹疗效观察[J].岭南皮肤性病科杂志,2008,15(3)：161-162
[16]刘涛,张燕萍.中药湿敷治疗急性、亚急性湿疹134例[J].宁夏医学杂志,1997,19(3)：183
[17]商燕畦,雷翠云.中药离子喷雾治疗亚急性湿疹效果观察[J].护理学杂志,2005,20(10)：45-46
[18]王延峰,李兰云,王文庆.湿疹油浸剂治疗亚急性肛门湿疹76例临床观察[J].河北中医,2009,31(1)：40-41
[19]张春香,刘家玉,王亚平.湿敷Ⅱ号液联合派瑞松霜治疗足部亚急性湿疹临床观察[J].中国麻风皮肤病病杂,2005,21,(5)：360
[20]高宜云,许月清.如意金黄散合尤卓尔治疗亚急性湿疹120例[J].浙江中医杂志,2004,39(11)：484
[21]邹继英.除湿止痒洗液治疗亚急性湿疹78例疗效观察[J].中医药临床杂,2008,20(4)：839-840
[22]黄霞,黄忠田.湿疹治验[J].光明中医,2008,2(1)：88-89
[23]马洪明,张新洁,乔嘉伟.自拟湿疹煎治疗急性、亚急性湿疹98例临床观察[J].中国麻风皮肤病杂志,2000,16(3)：147
[24]郭继华,张皖敏.自拟湿疹方为主治疗急性亚急性湿疹85例分析[J].安徽中医临床杂志,2002,14(1)：24-25
[25]黄尧洲.内外合治湿疹经验[J].中国中西医结合杂志,2008,28(8)：681
邢建军,宋玲娟,段逸群,等.丘疹性梅毒疹误诊1例.中国中西医结合皮肤性病学杂志.(待刊)