锦灯笼宿萼化学成分的分离与鉴定
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摘要
锦灯笼为茄科植物酸浆属植物Physalis alkekengi L．var．franchetii(Mast．)Makino的干燥宿萼或带果实的宿萼。气微，宿萼味苦，果实味甘，微酸。具有清热解毒、利咽、化痰、利尿的作用，常用于咽痛音哑，痰热咳嗽。
本文从锦灯笼中分离得到了11个化合物，其中8个化合物通过光谱及色谱手段确定了结构，分别是4，7-二脱氢新酸浆苦素B(4，7-didehydroneophysalin B)、酸浆苦素D(physalin D)、酸浆苦素P(physalin P)、β-谷甾醇(β-sitosterol)、木犀草素(luteolin)、木犀草素-7-葡萄糖苷(luteolin-7-glucoside)、3′，4′．二甲氧基杨梅皮素(3′，4′-dimethoxymyricetin)、胡萝卜苷(daucosterol)。其中3′，4′-二甲氧基杨梅皮素为首次从该植物中分离。对该药材的乙醇提取物进行了体外抗菌实验，证明锦灯笼的醇提物具有明显的抗菌活性，为该药材的新药开发和临床应用提供了实验基础。
Physalis alkekengi is persistent calyx with fruits or the dried persistent calyx of physalis alkekengi L. var. franchetii (Mast.) Makino. The persistent calyx is bitter and the fruits are sweet and slight acidic. It has the function of clearing away heat and toxic materials, relieving sore-throat and is proved to have obvious clinical effect.
We got eleven compounds from Physalis alkekengi through isolation. Eight of their structureshave been established by spectrum methods, which are 4,7-didehydroneophysalin B, physalin D, physalin P,β-sitosterol, luteolin, luteolin-7- glucoside, 3′,4′-dimethoxymyricetin and daucosterol. One of them named 3′,4′-dimethoxymyricetin is the first time isolated from this plant. Wesearched the antibacterial activity of extracts in ethanol in vitro and proved that it had obviously antibacterial activity, developing the demulcent therapy, reconciliation clinical application to provide the experiment basal for the new drugs.
本文从锦灯笼中分离得到了11个化合物，其中8个化合物通过光谱及色谱手段确定了结构，分别是4，7-二脱氢新酸浆苦素B(4，7-didehydroneophysalin B)、酸浆苦素D(physalin D)、酸浆苦素P(physalin P)、β-谷甾醇(β-sitosterol)、木犀草素(luteolin)、木犀草素-7-葡萄糖苷(luteolin-7-glucoside)、3′，4′．二甲氧基杨梅皮素(3′，4′-dimethoxymyricetin)、胡萝卜苷(daucosterol)。其中3′，4′-二甲氧基杨梅皮素为首次从该植物中分离。对该药材的乙醇提取物进行了体外抗菌实验，证明锦灯笼的醇提物具有明显的抗菌活性，为该药材的新药开发和临床应用提供了实验基础。
Physalis alkekengi is persistent calyx with fruits or the dried persistent calyx of physalis alkekengi L. var. franchetii (Mast.) Makino. The persistent calyx is bitter and the fruits are sweet and slight acidic. It has the function of clearing away heat and toxic materials, relieving sore-throat and is proved to have obvious clinical effect.
We got eleven compounds from Physalis alkekengi through isolation. Eight of their structureshave been established by spectrum methods, which are 4,7-didehydroneophysalin B, physalin D, physalin P,β-sitosterol, luteolin, luteolin-7- glucoside, 3′,4′-dimethoxymyricetin and daucosterol. One of them named 3′,4′-dimethoxymyricetin is the first time isolated from this plant. Wesearched the antibacterial activity of extracts in ethanol in vitro and proved that it had obviously antibacterial activity, developing the demulcent therapy, reconciliation clinical application to provide the experiment basal for the new drugs.
引文
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