新型荧光介孔纳米微粒的制备及应用
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摘要
功能化介孔二氧化硅材料由于在药物缓释体系,光学应用,染料掺杂能量传递等许多方面具有潜在的应用而成为研究热点。特别是荧光功能介孔材料由于在作为药物传递的载体,诊断分析和荧光标签等生物医学领域的潜在应用而受到广泛关注。不同的荧光发射中心,包括染料分子、共轭聚合物、稀土配合物、8-羟基喹啉接枝的金属配合物和CdSe/ZnS量子点(QDs)等已经被引入到介孔二氧化硅中,制备出了具有荧光发射特性的介孔材料。
本文选择介孔二氧化硅纳米粒子作为主体材料,分别通过原位生成和离子交换原位聚合的方法将8-羟基喹啉锌配合物(Znqx)和聚对苯撑乙烯(PPV)引入到介孔SiO_2纳米微粒中制备出具有不同荧光发射特性和稳定发光的介孔二氧化硅纳米微粒(MSNs)。此外,三(2,2-联吡啶)氯化钌和罗丹明6G染料还通过简单吸附法被成功引入到介孔SiO_2中。我们对这些不同荧光MSNs的结构和光物理性质进行了详细研究。研究结果表明:(1)在具有不同内环境的孔道中原位合成的8-羟基喹啉锌配合物(Znq_x)都以单配位(Znq)形式存在。这种原位生成方法得到的样品(MSNs-Znq)与通过简单的化学吸附法在孔中引入Znq_2的样品相比具有更好的荧光发射,并且在不同pH值下具有突出的光学稳定性。得到的荧光MSNs还可用于缓释布洛芬药物。(2) MSNs孔道内原位生成的PPV含量和介孔二氧化硅微粒的大小都对PPV@MSNs复合纳米微粒的发光性质有影响。我们所制备的这些不同荧光介孔二氧化硅纳米微粒均可分散在水中,这使它们在药物缓释、生物标记及基因载体等生物学方面具有重要的应用价值。
Functionalized mesoporous silica materials have received much attention because of their potential applications in areas such as drug-delivery systems, optical and dye-doped energy-transfer schemes. Fluorescent mesoporous silica nanoparticles have received considerable attention, since the materials hold great promise for biomedical applications such as drug delivery carriers, diagnostic analysis and ?uorescent labeling. Different emission centers, including dye molecules, conjugated polymers, rare earth complexes, 8-hydroxyquinoline grafting metal complexes and CdSe/ZnS quantum dots (QDs) have already been introduced into the mesoporous silica to prepare high fluorescence mesoporous materials.
In this study, we choose the mesoporous silica as host material, incorporated 8-hydroxyquinolinate zinc complexes (Znqx) and poly(p-phenylenevinylene) (PPV) into the channels of mesoporous silica nanoparticles by in situ formation and in situ polymerization method. Tris(2,2'-bipyridyl)ruthenium(II) chloride hexahydrate and Rhodamine 6G have also been successfully introduced into the mesoporous silica by direct chemical adsorption. Thus, through this way, we prepared different fluorescence mesoporous silica nanoparticles (MSNs) with stable emission. At the same time, the structures and photophysical properties of the different fluorescent MSNs were studied in detail. The results show that: (1) the 8-hydroxyquinolinate zinc complexes (Znqx) in situ synthesized in the channels of MSNs with different inner surroundings were determined as a single coordination mode (Znq). The MSNs-Znq obtained by in situ generation procedure possess highly ?uorescence emission, outstanding optical stability at different pH values as compared with that obtained by direct chemical adsorption of Znq2. The obtained ?uorescent MSNs were used in the controlled release of ibuprofen. (2) The fluorescence properties of PPV@MSNs composite materials depend on the concentration of PPV in MSNs and the size of mesoporous silica particles. The different fluorescent mesoporous silica nanoparticles can be dispersed in water, which makes them have the potential applications in biomedical fields such as drug delivery, biological markers and gene carriers.
本文选择介孔二氧化硅纳米粒子作为主体材料,分别通过原位生成和离子交换原位聚合的方法将8-羟基喹啉锌配合物(Znqx)和聚对苯撑乙烯(PPV)引入到介孔SiO_2纳米微粒中制备出具有不同荧光发射特性和稳定发光的介孔二氧化硅纳米微粒(MSNs)。此外,三(2,2-联吡啶)氯化钌和罗丹明6G染料还通过简单吸附法被成功引入到介孔SiO_2中。我们对这些不同荧光MSNs的结构和光物理性质进行了详细研究。研究结果表明:(1)在具有不同内环境的孔道中原位合成的8-羟基喹啉锌配合物(Znq_x)都以单配位(Znq)形式存在。这种原位生成方法得到的样品(MSNs-Znq)与通过简单的化学吸附法在孔中引入Znq_2的样品相比具有更好的荧光发射,并且在不同pH值下具有突出的光学稳定性。得到的荧光MSNs还可用于缓释布洛芬药物。(2) MSNs孔道内原位生成的PPV含量和介孔二氧化硅微粒的大小都对PPV@MSNs复合纳米微粒的发光性质有影响。我们所制备的这些不同荧光介孔二氧化硅纳米微粒均可分散在水中,这使它们在药物缓释、生物标记及基因载体等生物学方面具有重要的应用价值。
Functionalized mesoporous silica materials have received much attention because of their potential applications in areas such as drug-delivery systems, optical and dye-doped energy-transfer schemes. Fluorescent mesoporous silica nanoparticles have received considerable attention, since the materials hold great promise for biomedical applications such as drug delivery carriers, diagnostic analysis and ?uorescent labeling. Different emission centers, including dye molecules, conjugated polymers, rare earth complexes, 8-hydroxyquinoline grafting metal complexes and CdSe/ZnS quantum dots (QDs) have already been introduced into the mesoporous silica to prepare high fluorescence mesoporous materials.
In this study, we choose the mesoporous silica as host material, incorporated 8-hydroxyquinolinate zinc complexes (Znqx) and poly(p-phenylenevinylene) (PPV) into the channels of mesoporous silica nanoparticles by in situ formation and in situ polymerization method. Tris(2,2'-bipyridyl)ruthenium(II) chloride hexahydrate and Rhodamine 6G have also been successfully introduced into the mesoporous silica by direct chemical adsorption. Thus, through this way, we prepared different fluorescence mesoporous silica nanoparticles (MSNs) with stable emission. At the same time, the structures and photophysical properties of the different fluorescent MSNs were studied in detail. The results show that: (1) the 8-hydroxyquinolinate zinc complexes (Znqx) in situ synthesized in the channels of MSNs with different inner surroundings were determined as a single coordination mode (Znq). The MSNs-Znq obtained by in situ generation procedure possess highly ?uorescence emission, outstanding optical stability at different pH values as compared with that obtained by direct chemical adsorption of Znq2. The obtained ?uorescent MSNs were used in the controlled release of ibuprofen. (2) The fluorescence properties of PPV@MSNs composite materials depend on the concentration of PPV in MSNs and the size of mesoporous silica particles. The different fluorescent mesoporous silica nanoparticles can be dispersed in water, which makes them have the potential applications in biomedical fields such as drug delivery, biological markers and gene carriers.
引文
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