我院10年间ICP发生率的变迁及妊娠结局分析
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摘要
目的:探讨新疆医科大学第一附属医院十年间妊娠期肝内胆汁淤积症(ICP)发生率变迁、不同民族之间发生率及妊娠结局比较。方法:选择自1999年1月1日至2008年12月31日期间在我院住院的ICP孕妇共626例为研究对象,排除有合并症并在我院剖宫产分娩的ICP患者有397例,按民族分为汉族、维吾尔族、哈萨克族、回族四个组,对十年间、各民族间发生率及母婴并发症进行统计分析。结果:1999年至2008年总十年ICP发生率为4.10%,各年间ICP发生率分别13.98%、11.57%、8.2%、1.60%、1.70%、2.78%、2.62%、4.02%、3.9%、5.28%,汉族、维吾尔族、哈萨克族、回族中ICP发生率分别3.47%、7.35%、6.02%、3.14%,维吾尔族与汉族、回族之间(x2 =70.554、15.212),p<0.0083,差异有统计学意义,汉族与哈萨克族、回族,哈萨克族与维吾尔族、回族之间(x2 =5.556、0.211、0.694、4.436),p>0.0083,差异无统计学意义。十年间ICP分娩孕妇发生早产率为16.62%,羊水污染率为19.14%,胎儿窘迫发生率为4.53%,新生儿窒息发生率为8.56%,产后出血发生率为0.76%,无发生死胎、死产及新生儿死亡。各民族间早产(x2 =17.400,p=0.001),p<0.05,差异有统计学意义,其余无统计学意义。行其各民族间两两比较,维吾尔族与汉族早产(x2 =14.342,p=0.000),p<0.0083,差异有统计学意义,羊水污染、胎儿宫内窘迫、新生儿窒息、产后出血(x2 =4.816、1.698、7.519、1.398),p>0.05,差异无统计学意义。结论:十年间我院ICP发生率呈先高后低,又缓慢上升趋势。维吾尔族ICP的发生率高于汉族和回族,且维吾尔族发生早产率高于汉族。因此,应重视少数民族的ICP患者,并早期、合理地治疗少数民族ICP患者。
Objective: To explore the First Affiliated Hospital of Xinjiang Medical University, ten years in intrahepatic cholestasis of pregnancy (ICP) the incidence of changes in incidence among different ethnic groups, and compared pregnancy outcomes. Methods: Since January 1, 1999 to December 2008 31 of the ICP in our hospital a total of 626 cases of pregnant women as research object, rule out complications and caesarean section deliveries in our hospital 397 cases of ICP patients , divided by ethnic Han, Uygur, Kazak, Hui four groups of ten years, the incidence of various nationalities and perinatal complications were analyzed. Results: from 1999 to 2008 decade, the total rate of 4.10% occurred ICP, ICP for each year, rates were 13.98%, 11.57%, 8.2%, 1.60%, 1.70%, 2.78%, 2.62%, 4.02%, 3.9%, 5.28%, the Han, Uygur, Kazak, Hui ICP in incidence of 3.47%, 7.35%, 6.02%, 3.14%, Uygur and Han, Hui between (x2 = 70.554,15.212), p <0.0083, difference statistically significant, Han and Kazak, Hui, Kazak and Uygur, Hui between (x2 = 5.556,0.211,0.694,4.436), p> 0.0083, difference was not statistically significant. Decade, ICP occurs in premature birth rate of pregnant women, 16.62%, sheep and water pollution rate of 19.14%, fetal distress rate was 4.53%, neonatal asphyxia incidence of 8.56%, the incidence of postpartum hemorrhage was 0.76%, no place stillbirth, stillbirth and newborn deaths. Preterm birth among various ethnic groups (x2 = 17.400, p = 0.001), p <0.05, statistically significant differences between the remaining non-statistical significance. Line 22 of its inter-ethnic comparison, the Uygur and Han preterm (x2 = 14.342, p = 0.000), p <0.0083, the difference was statistically significant, sheep and water pollution, fetal distress, neonatal asphyxia, postpartum hemorrhage (x2 = 4.816,1.698,7.519,1.398), p> 0.05, difference was not statistically significant. Conclusion: The ten years in our hospital the incidence of ICP was the first high to low, then slowly rise. ICP is higher than the incidence of Uighur and Hui Han and Uygur preterm birth rate of occurrence is higher than the Han. Therefore, we should focus on minority ICP patients with early and reasonable treatment of minority patients with ICP.
Objective: To explore the First Affiliated Hospital of Xinjiang Medical University, ten years in intrahepatic cholestasis of pregnancy (ICP) the incidence of changes in incidence among different ethnic groups, and compared pregnancy outcomes. Methods: Since January 1, 1999 to December 2008 31 of the ICP in our hospital a total of 626 cases of pregnant women as research object, rule out complications and caesarean section deliveries in our hospital 397 cases of ICP patients , divided by ethnic Han, Uygur, Kazak, Hui four groups of ten years, the incidence of various nationalities and perinatal complications were analyzed. Results: from 1999 to 2008 decade, the total rate of 4.10% occurred ICP, ICP for each year, rates were 13.98%, 11.57%, 8.2%, 1.60%, 1.70%, 2.78%, 2.62%, 4.02%, 3.9%, 5.28%, the Han, Uygur, Kazak, Hui ICP in incidence of 3.47%, 7.35%, 6.02%, 3.14%, Uygur and Han, Hui between (x2 = 70.554,15.212), p <0.0083, difference statistically significant, Han and Kazak, Hui, Kazak and Uygur, Hui between (x2 = 5.556,0.211,0.694,4.436), p> 0.0083, difference was not statistically significant. Decade, ICP occurs in premature birth rate of pregnant women, 16.62%, sheep and water pollution rate of 19.14%, fetal distress rate was 4.53%, neonatal asphyxia incidence of 8.56%, the incidence of postpartum hemorrhage was 0.76%, no place stillbirth, stillbirth and newborn deaths. Preterm birth among various ethnic groups (x2 = 17.400, p = 0.001), p <0.05, statistically significant differences between the remaining non-statistical significance. Line 22 of its inter-ethnic comparison, the Uygur and Han preterm (x2 = 14.342, p = 0.000), p <0.0083, the difference was statistically significant, sheep and water pollution, fetal distress, neonatal asphyxia, postpartum hemorrhage (x2 = 4.816,1.698,7.519,1.398), p> 0.05, difference was not statistically significant. Conclusion: The ten years in our hospital the incidence of ICP was the first high to low, then slowly rise. ICP is higher than the incidence of Uighur and Hui Han and Uygur preterm birth rate of occurrence is higher than the Han. Therefore, we should focus on minority ICP patients with early and reasonable treatment of minority patients with ICP.
引文
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