中医药综合疗法治疗葡萄膜炎方案的规范化临床研究
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摘要
目的：应用中医药综合疗法治疗葡萄膜炎,观察其临床疗效,并为规范中西医治疗葡萄膜炎方案提供依据。方法：将符合纳入标准的葡萄膜炎患者,先确定其葡萄膜炎类型,再将每一类型的所属葡萄膜炎患者按随机化原则分在治疗组和对照组,共329例。其中治疗组167例,226眼。对照组162例,223眼。治疗组以中医药综合疗法治疗,对照组以西医治疗。观察临床疗效、症状和体征缓解程度、视力提高、病程、复发率、糖皮质激素的不良反应等临床资料。结果：临床研究表明,治疗组总体与对照组相比,其在临床疗效、缓解临床症状和体征、视力提高、复发率、减少糖皮质激素的不良反应方面有显著性差异(P<0.05),治疗组总体优于对照组；两组总体在病程长短上差别不明显(P)0.05)。结论：中医药综合疗法治疗葡萄膜炎取得了较好的临床效果,具有明显提高临床疗效、缓解症状和体征、提高视力、减少复发、减少糖皮质激素的不良反应等优点,是一种安全有效、疗效较好、患者依从性较好的治疗方法,值得临床推广应用。
Objective:Treating the uveitis with the traditional chinese medicine composite treatmentes, to observe its clinical curative effect, and to provide the basis for the standard treating plan of the uveitis with the traditional chinese medicine and western medicine. Method:Selected 329 the uveitis patients who conform to the standard, to decide the type of the uveitis first, and then put the patients of each of the uveitis into the treatment group and the control group according to the randomisation principle,167 cases (226 eyes)in the treatment group,162 cases(223 eyes) in the control group. The treatment group was treated with traditional chinese medicine composite treatmentes,and the control group was treated with the western medicine therapy,to observe their clinical materiales:the clinical curative effect, the alleviation of symptoms,the enhancing of the vision, the clinical course, the recurrence rate, the adverse reactions of the glucocorticoid. Result:The clinical research indicated that the treatment group has the significant difference compared with the control group in the the clinical curative effect, the alleviation of symptom, the enhancing of the vision, the recurrence rate and the adverse reactions of the glucocorticoid(P< 0.05). The treatment group surpasses the control group. The clinical courses of the two groups has not the significant difference (P>0.05). Conclusion:Treating uveitis with the traditional Chinese medicine composite treatmentes gets the good clinical effect.It enhances the clinical curative effect, alleviates the symptom of the uveitis, enhances the vision, reduces the recrudescence of the uveitis,and reduces the adverse reaction of the glucocorticoid. It was one kind of good method of treatment that is securite and effective.It has good compliance of the patients.It is a clinical application worth to be promoted.
Objective:Treating the uveitis with the traditional chinese medicine composite treatmentes, to observe its clinical curative effect, and to provide the basis for the standard treating plan of the uveitis with the traditional chinese medicine and western medicine. Method:Selected 329 the uveitis patients who conform to the standard, to decide the type of the uveitis first, and then put the patients of each of the uveitis into the treatment group and the control group according to the randomisation principle,167 cases (226 eyes)in the treatment group,162 cases(223 eyes) in the control group. The treatment group was treated with traditional chinese medicine composite treatmentes,and the control group was treated with the western medicine therapy,to observe their clinical materiales:the clinical curative effect, the alleviation of symptoms,the enhancing of the vision, the clinical course, the recurrence rate, the adverse reactions of the glucocorticoid. Result:The clinical research indicated that the treatment group has the significant difference compared with the control group in the the clinical curative effect, the alleviation of symptom, the enhancing of the vision, the recurrence rate and the adverse reactions of the glucocorticoid(P< 0.05). The treatment group surpasses the control group. The clinical courses of the two groups has not the significant difference (P>0.05). Conclusion:Treating uveitis with the traditional Chinese medicine composite treatmentes gets the good clinical effect.It enhances the clinical curative effect, alleviates the symptom of the uveitis, enhances the vision, reduces the recrudescence of the uveitis,and reduces the adverse reaction of the glucocorticoid. It was one kind of good method of treatment that is securite and effective.It has good compliance of the patients.It is a clinical application worth to be promoted.
引文
[1]葛坚.眼科学[M].第一版.北京：人民卫生出版社,2005,8：275-276
[2]廖品正.中医眼科学[M]。上海：上海科技出版社,1997：101-104,114,119
[3]姚芳蔚.葡萄膜炎辨证施治[J].中西医结合眼科杂志,1997,15(3)：129-131
[4]章淑华,陆绵绵.治疗葡萄膜炎的经验[J].湖北中医杂志,2000,22(6)：3-4
[5]刘志宏,张庆莲.中药内服外熏治疗憧神紧小症84例[J].长春中医学院学报,2004,20(1)：11
[6]刘晶晶,崔浩,傅少颖,等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[7]孙虹,孟亚泉,王素兰.针灸联合扩瞳治疗虹膜睫状体炎疗效观察[J].现代中西医结合杂志,2004,13(24)：：3278-3279
[8]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454-455
[9]郜青叶,王翠珍等.中药“熏疗”治疗眼外伤及手术后并发症等350例[J].眼外伤职业眼病杂志,2004,26(2)：130
[10]中医病证诊断疗效标准.国家中医药管理局[M].zy/T001.5-94：107
[11]Bloch ME, Nussenblatt RB. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol,1987,103: 234-235.
[12]杨培增,李绍珍,主编.葡萄膜炎[M].北京：人民卫生出版社,1998.157-158.
[13]李凤鸣.《眼科全书》[M]上册.第一版.人民卫生出版社,1996： 655
[14]杨培增.葡萄膜炎的研究进展[J].中华眼底病杂志,2005,41：1150
[15]杨培增.葡萄膜炎的诊断及相关问题[J].中华眼底病杂志,2002,38： 252
[16]杨培增.准确诊断和合理治疗葡萄膜炎[J].中华眼底病杂志,2004,40：：506
[17]谭敏治,胡因铭,赵诗云.龙胆泻肝汤的药理作用研究[J],中药药理与临床.1991,7(1)：5-7
[18]肖哲夫,夏远春,曾明葵.抑阳酒连散对急性葡萄膜炎模型大鼠房水及外周血TNF-a的影响[J].中医药导报,2009,15(3)：69-71
[19]王永炎,庄曾渊.今日中医眼科[M],北京：人民卫生出版社,2000,128-129.
[20]刘静霞,陈大颖.葡萄膜炎的中西医防治研究[J].中华现代眼耳鼻喉科杂志,2007,4(4)：314.
[21]陆南山.吴氏玉女煎治疗亚急性虹膜炎[J].中西医结合杂志,1981,1(1)：91.
[22]郑虎占,主编.中药现代研究与应用(第二卷)[M].北京：学苑出版社,1997.1760.
[23]施玉华.中药对小鼠氢化考的松模型小肠浆细胞IgG及腹膜肥大细胞的影响[J].中西医结合杂志,1984.4(2)：104.
[24]蔡定芳.右归饮对大鼠下丘脑-垂体-肾上腺-胸腺轴抑制模型的影响[J].中国免疫学杂志,1994,10(4)：236.
[25]吴铁.壮骨肾宝对抗泼尼松不良反应的实验研究[J].中国中医药科技,1996,3(4)：16.
[26]吴铁.淫羊藿对抗肾上腺皮质激素不良反应的实验研究[J].中国中药杂志,1996,21(12)：748.
[27]骆保.益气助阳养血滋阴方药对氢化可的松作用下的小鼠腹腔巨噬细胞Fc、C3b受体的调整作用[J].北京医科大学学报,1987, 19(6)：419.
[28]叶任高,梁萌.中药配合激素治疗原发性肾病综合征[J].中西医结合临床杂志,1991,(创刊号)：1-4.
[29]张丽丽.长期用激素动物模型对温肾与滋肾药的不同效应探讨[J].上海中医药杂志,1988,(3)：46.
[30]梁俊芳.中西医结合治疗葡萄膜大脑炎32例[J].上海中医药杂志,2001,35(4)：32-33.
[31]邓春雷,殷克敬,主编.实验针灸学[M].北京：人民卫生出版社,1998：359-373.
[32]孙华.针灸治疗类风湿关节炎研究进展[J].中国针灸,2001,21(3)：186-187.
[33]石德光.针刺对慢性炎症疾病中炎症介质的影响[J].中国针灸,2003,23(7)：429-430.
[34]李忠仁,沈梅红,曲鹤年,等.针刺阻抑和延缓自内障形成的机理研究[J].中国针灸,2003,23(9)：548.
[35]高巍,黄裕新,陈洪,等.电针“足三里”对大鼠脑肠肽含量的影响及其对免疫系统的调控作用[J].针刺研究,2002,27(1)：50-55.
[36]和中浚,袁晓辉.熏眼法及熏眼方药的治疗特色[J].中国中医眼科杂志,2002,12(4)：232-233
[37]刘晶晶,崔浩等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[38]乔志恒简易物理疗法[M].第2版.北京：人民出版杜,1984,35-46
[39]A.戈尔茨坦L.阿罗诺夫S.M.卡尔曼等,药物作用原理[M].北京：科学出版社,198-1.118-120.
[40]A.M.柯克.医用治疗设备应用和设计[M].上海：上海科学出版社,1988,149.
[41]朱立刚.清开灵注射液致过敏反应11例[J].浙江中医杂志,2001,36(9)：388
[42]阮克宽,白云辉.清开灵注射液致过敏反应2例[J].中国药师,2002,5(6)：363
[43]宋立.清开灵在眼科临床的应用示例[J].中国中医眼科杂志,1993,.3(4)：231-232
[44]孔玉峰,程远.清开灵注射液在眼科疾病中的应用体会[J].实用中医药杂志,2003,19(2)：94
[45]毛华,马荣,高淑清,等.清开灵注射液治疗眼科疾病的临床分析[J].中国实用眼科杂志,1997,,15(6)：381
[46]Suzuki Y,Kondo K,Ikeda Y, Umemura K.Antithrombotic effect of geniposide and genipin in the mouse thrombosis model.Planta Med,2001,67(9):807-810
[47]Kou WH.Wang CJ,Young SC,etc..Differential induction of the expression of GST subunits by geniposide in ra the patocytes Pharmacology,2004,70(1):15-22
[48]胡士星,李绍珍,谢楚芳,等.清开灵对T淋巴细胞有丝分裂反应的影响[J].中国实验免疫学杂志,1992,4：45-47
[49]朱琏著,主编.新针灸学[M].北京：人民卫生出版社,1954.321-323.
[50]杨培增.我国葡萄膜炎的诊治水平亟待提高[J].中华眼科杂志,2005,38：193-195
[1]廖品正.中医眼科学[M]。上海：上海科技出版社,1997.：101-104,114,119
[2]姚芳蔚.葡萄膜炎辨证施治[J].中西医结合眼科杂志,1997,15(3)：129-131
[3]章淑华,陆绵绵.治疗葡萄膜炎的经验[J].湖北中医杂志,2000,22(6)：3-4
[4]刘志宏,张庆莲.中药内服外熏治疗憧神紧小症84例[J].长春中医学院学报,2004,20(1)：11
[5]刘晶晶,崔浩,傅少颖,等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[6]孙虹,孟亚泉,王素兰.针灸联合扩瞳治疗虹脱睫状体炎疗效观察[J].现代中西医结合杂志,2004,13(24)：3278-3279
[7]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454—455
[8]郜青叶,王翠珍等.中药“熏疗”治疗眼外伤及手术后并发症等350例[J].眼外伤职业眼病杂志,2004,26(2)：130
[9]Yang PZ, Chen L, Zwart R, etc.Immune cells in the porcine retina Distribution, characterization, morphological features. Invest Ophthalmol V is Sci 2002,43: 1488-1492.
[10]Chen L, Yang PZ, KijlstraA. Distribution, markers and functions of retinal microglia. Ocul Immunol Inflamma,2002,10:27-39.
[11]Yang PZ, Das PK, Kijlstra A. Localization and characterization of immunocompetent cells in the retina. Ocul Immunol Inflamma,2000.8:149-157.
[12]Rao NA, Kimoto T, Zamir E, etc.Pathogenic role of retinal microglia in experime-ntal uveoretinitis. InvestOphthalmol Vis Sci,2003,44:22-31.
[13]RaiG, Saxena S, KumarH, etc.Human retinalS-antigen:T cell epitopemapping in posterioruveitispatients. ExpMolPathol.2001,70:140-145.
[14]LiB, Yang PZ, ZhouHY, etc. T-bet expression is upregulated in active Behcet's disease. Br JOphthalmol.2003,87:1264-1267.
[15]Yang PZ, Herzberg NH, Zhou HY, etc.Apoptosis of infiltrating cells in experimental autoimmune uveoretinitis. ChinMed J,2000,113:643-646.
[16]Yang P, Justine R, Smith K, etc. Visualization of cell death in vivo duringmurine endotoxin-induced uveitis. InvestOphthalmolVis Sci 2003,44:1993-1997.
[17]Yang PZ, JiL, ZhouHY, etc. Disturbed expression of Fas/FasL on CD4+ and CD8+ T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome and Idiopathic anterior uveitis. Ocul Immunol Inflamma,2001,9:185-191.
[18]Yang PZ, Chen L, Zhou HY, etc.Resistance of lymphocytes to Fas-mediated apoptosis in Behcet's disease and Vogt-Koyanagi-Harada syndrome. Ocul Immunol Inflamma, 2002.10：47-52.
[19]杨培增.葡萄膜炎的研究进展[J].中华眼科杂志,2005,41：1149-1151
[20]杨培增.葡萄膜炎免疫治疗的进展与展望[J].中华眼科杂志,2002,38：574-576
[21]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454-455.
[22]陈丽芳.中药为主治疗色素膜炎[J].中国中医眼科杂志.1993.3：78
[23]徐先耀.中西医综合治疗葡萄膜炎疗效观察[J].中西医结合眼科,1986；5(4)：3
[24]周先贡.中西医综合治疗葡萄膜炎疗效观察[J].中西医结合眼科,1986.6(4)：23
[25]杨培增.准确诊断和合理治疗葡萄膜炎[J].中华眼科杂志,2004,40：505-506
[26]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454-455.
[27]庞凤,郑新青.中西医结合治疗特殊类型葡萄膜炎36例临床分析[J].山东中医药大学学报,2002,26(2)：118-119.
[28]张红,巢国俊,庄曾渊.辩证治疗全葡萄膜炎并发渗出性视网膜脱离2例[J].中国中药眼科杂志,2002,12(3)：169-169.
[29]许立军,陈少军,何春燕,等.竹叶石膏汤加减预防葡萄膜炎治疗中的激素反跳现象[J].中西医结合眼科杂志,1997,15(3)：133-134
[30]赵桂霞.半夏泻心汤治疗葡萄膜炎的体会[J].中国中医眼科杂志,2000,10(2)：113-114
[31]郭霞,吕璐,刘玲,等.抗炎明目袋泡剂治疗慢性葡萄膜炎临床研究[J].山东中医药大学学报,2001,25(4)：256
[32]徐大梅,吕海江.清肝利湿汤治疗急性前葡萄膜炎100例[J].中医研究,1998,11(5)：22-23.
[33]崔文治.复明冲剂对急性葡萄膜炎患者视野的影响[J].中国中医眼科杂志,1999,11(9)：13-16.
[34]胡士星,李绍珍,谢楚芳,等.清开灵对T淋巴细胞有丝分裂反应的影响[J].中国实验免疫学杂志,1992,4：45-47
[35]刘晶晶,崔浩,傅少颖,等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[36]孙虹,孟亚泉,王素兰.针灸联合扩瞳治疗虹膜睫状体炎疗效观察[J].现代中西医结合杂志,2004,13(24)：3278-3279
[37]张铭端,等.白芍总贰对内因性葡萄膜炎患者的免疫调节作用[J].中华眼底病杂志,1994,10(3)：14
[38]蔡桂英.雷公藤治疗慢性色素膜炎[J].中西医结合眼科杂志,1997,15(3)：140-141
[39]马翠萍,杨培增,钟晖,等.汉防已碱对实验性葡萄膜炎的抑制作用[J].中山大学学报(医学科学版),2003,24(1)：74-76
[40]杨培增,王红,周红颜,等.葡萄膜炎药物治疗中的问题分析[J].中华眼科杂志,2004,40(10)：679-682.
[41]杨培增,李绍珍,谢楚芳.Behet病的现代药物治疗.中华眼底病杂志,1994,10：138-141.
[42]杨培增,著.临床葡萄膜炎[M].北京：人民卫生出版社,2004.33-178,107-210.
[43]K tter I, Zierhut M, Eckstein AK, etc. Human recombinant interferon alfa-2a for the treatment of Behcet's disease with sight threatening posteriororpanuveitis. Br JOphthalmol.2003,87:423-431.
[44]JosephA, Raj D, Dua HS, etc. Infliximab in the treatment of refractory posterioruveitis. Ophthalmology,2003,110:1449-1453.
[45]FosterCS, VitaleAT. Immunosuprressive chemotherapy. In:Foster CS, Vital AT, eds. Diagnosis and treatment of uveitis.Philadelphia:WB Saunders,2002.177-214.
[46]Tacrolimus (FK506) in the treatment ofposterior uveitis refratory to cyclosporine. Ophthalmology,1999,106:723-728.
[47]Thurau SR, W ildnerG Oral tolerance for treating uveitis-new hope for an old immunologicalme chanism. Prog Retin Eye Res,2002,21:577-589.
[2]廖品正.中医眼科学[M]。上海：上海科技出版社,1997：101-104,114,119
[3]姚芳蔚.葡萄膜炎辨证施治[J].中西医结合眼科杂志,1997,15(3)：129-131
[4]章淑华,陆绵绵.治疗葡萄膜炎的经验[J].湖北中医杂志,2000,22(6)：3-4
[5]刘志宏,张庆莲.中药内服外熏治疗憧神紧小症84例[J].长春中医学院学报,2004,20(1)：11
[6]刘晶晶,崔浩,傅少颖,等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[7]孙虹,孟亚泉,王素兰.针灸联合扩瞳治疗虹膜睫状体炎疗效观察[J].现代中西医结合杂志,2004,13(24)：：3278-3279
[8]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454-455
[9]郜青叶,王翠珍等.中药“熏疗”治疗眼外伤及手术后并发症等350例[J].眼外伤职业眼病杂志,2004,26(2)：130
[10]中医病证诊断疗效标准.国家中医药管理局[M].zy/T001.5-94：107
[11]Bloch ME, Nussenblatt RB. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol,1987,103: 234-235.
[12]杨培增,李绍珍,主编.葡萄膜炎[M].北京：人民卫生出版社,1998.157-158.
[13]李凤鸣.《眼科全书》[M]上册.第一版.人民卫生出版社,1996： 655
[14]杨培增.葡萄膜炎的研究进展[J].中华眼底病杂志,2005,41：1150
[15]杨培增.葡萄膜炎的诊断及相关问题[J].中华眼底病杂志,2002,38： 252
[16]杨培增.准确诊断和合理治疗葡萄膜炎[J].中华眼底病杂志,2004,40：：506
[17]谭敏治,胡因铭,赵诗云.龙胆泻肝汤的药理作用研究[J],中药药理与临床.1991,7(1)：5-7
[18]肖哲夫,夏远春,曾明葵.抑阳酒连散对急性葡萄膜炎模型大鼠房水及外周血TNF-a的影响[J].中医药导报,2009,15(3)：69-71
[19]王永炎,庄曾渊.今日中医眼科[M],北京：人民卫生出版社,2000,128-129.
[20]刘静霞,陈大颖.葡萄膜炎的中西医防治研究[J].中华现代眼耳鼻喉科杂志,2007,4(4)：314.
[21]陆南山.吴氏玉女煎治疗亚急性虹膜炎[J].中西医结合杂志,1981,1(1)：91.
[22]郑虎占,主编.中药现代研究与应用(第二卷)[M].北京：学苑出版社,1997.1760.
[23]施玉华.中药对小鼠氢化考的松模型小肠浆细胞IgG及腹膜肥大细胞的影响[J].中西医结合杂志,1984.4(2)：104.
[24]蔡定芳.右归饮对大鼠下丘脑-垂体-肾上腺-胸腺轴抑制模型的影响[J].中国免疫学杂志,1994,10(4)：236.
[25]吴铁.壮骨肾宝对抗泼尼松不良反应的实验研究[J].中国中医药科技,1996,3(4)：16.
[26]吴铁.淫羊藿对抗肾上腺皮质激素不良反应的实验研究[J].中国中药杂志,1996,21(12)：748.
[27]骆保.益气助阳养血滋阴方药对氢化可的松作用下的小鼠腹腔巨噬细胞Fc、C3b受体的调整作用[J].北京医科大学学报,1987, 19(6)：419.
[28]叶任高,梁萌.中药配合激素治疗原发性肾病综合征[J].中西医结合临床杂志,1991,(创刊号)：1-4.
[29]张丽丽.长期用激素动物模型对温肾与滋肾药的不同效应探讨[J].上海中医药杂志,1988,(3)：46.
[30]梁俊芳.中西医结合治疗葡萄膜大脑炎32例[J].上海中医药杂志,2001,35(4)：32-33.
[31]邓春雷,殷克敬,主编.实验针灸学[M].北京：人民卫生出版社,1998：359-373.
[32]孙华.针灸治疗类风湿关节炎研究进展[J].中国针灸,2001,21(3)：186-187.
[33]石德光.针刺对慢性炎症疾病中炎症介质的影响[J].中国针灸,2003,23(7)：429-430.
[34]李忠仁,沈梅红,曲鹤年,等.针刺阻抑和延缓自内障形成的机理研究[J].中国针灸,2003,23(9)：548.
[35]高巍,黄裕新,陈洪,等.电针“足三里”对大鼠脑肠肽含量的影响及其对免疫系统的调控作用[J].针刺研究,2002,27(1)：50-55.
[36]和中浚,袁晓辉.熏眼法及熏眼方药的治疗特色[J].中国中医眼科杂志,2002,12(4)：232-233
[37]刘晶晶,崔浩等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[38]乔志恒简易物理疗法[M].第2版.北京：人民出版杜,1984,35-46
[39]A.戈尔茨坦L.阿罗诺夫S.M.卡尔曼等,药物作用原理[M].北京：科学出版社,198-1.118-120.
[40]A.M.柯克.医用治疗设备应用和设计[M].上海：上海科学出版社,1988,149.
[41]朱立刚.清开灵注射液致过敏反应11例[J].浙江中医杂志,2001,36(9)：388
[42]阮克宽,白云辉.清开灵注射液致过敏反应2例[J].中国药师,2002,5(6)：363
[43]宋立.清开灵在眼科临床的应用示例[J].中国中医眼科杂志,1993,.3(4)：231-232
[44]孔玉峰,程远.清开灵注射液在眼科疾病中的应用体会[J].实用中医药杂志,2003,19(2)：94
[45]毛华,马荣,高淑清,等.清开灵注射液治疗眼科疾病的临床分析[J].中国实用眼科杂志,1997,,15(6)：381
[46]Suzuki Y,Kondo K,Ikeda Y, Umemura K.Antithrombotic effect of geniposide and genipin in the mouse thrombosis model.Planta Med,2001,67(9):807-810
[47]Kou WH.Wang CJ,Young SC,etc..Differential induction of the expression of GST subunits by geniposide in ra the patocytes Pharmacology,2004,70(1):15-22
[48]胡士星,李绍珍,谢楚芳,等.清开灵对T淋巴细胞有丝分裂反应的影响[J].中国实验免疫学杂志,1992,4：45-47
[49]朱琏著,主编.新针灸学[M].北京：人民卫生出版社,1954.321-323.
[50]杨培增.我国葡萄膜炎的诊治水平亟待提高[J].中华眼科杂志,2005,38：193-195
[1]廖品正.中医眼科学[M]。上海：上海科技出版社,1997.：101-104,114,119
[2]姚芳蔚.葡萄膜炎辨证施治[J].中西医结合眼科杂志,1997,15(3)：129-131
[3]章淑华,陆绵绵.治疗葡萄膜炎的经验[J].湖北中医杂志,2000,22(6)：3-4
[4]刘志宏,张庆莲.中药内服外熏治疗憧神紧小症84例[J].长春中医学院学报,2004,20(1)：11
[5]刘晶晶,崔浩,傅少颖,等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[6]孙虹,孟亚泉,王素兰.针灸联合扩瞳治疗虹脱睫状体炎疗效观察[J].现代中西医结合杂志,2004,13(24)：3278-3279
[7]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454—455
[8]郜青叶,王翠珍等.中药“熏疗”治疗眼外伤及手术后并发症等350例[J].眼外伤职业眼病杂志,2004,26(2)：130
[9]Yang PZ, Chen L, Zwart R, etc.Immune cells in the porcine retina Distribution, characterization, morphological features. Invest Ophthalmol V is Sci 2002,43: 1488-1492.
[10]Chen L, Yang PZ, KijlstraA. Distribution, markers and functions of retinal microglia. Ocul Immunol Inflamma,2002,10:27-39.
[11]Yang PZ, Das PK, Kijlstra A. Localization and characterization of immunocompetent cells in the retina. Ocul Immunol Inflamma,2000.8:149-157.
[12]Rao NA, Kimoto T, Zamir E, etc.Pathogenic role of retinal microglia in experime-ntal uveoretinitis. InvestOphthalmol Vis Sci,2003,44:22-31.
[13]RaiG, Saxena S, KumarH, etc.Human retinalS-antigen:T cell epitopemapping in posterioruveitispatients. ExpMolPathol.2001,70:140-145.
[14]LiB, Yang PZ, ZhouHY, etc. T-bet expression is upregulated in active Behcet's disease. Br JOphthalmol.2003,87:1264-1267.
[15]Yang PZ, Herzberg NH, Zhou HY, etc.Apoptosis of infiltrating cells in experimental autoimmune uveoretinitis. ChinMed J,2000,113:643-646.
[16]Yang P, Justine R, Smith K, etc. Visualization of cell death in vivo duringmurine endotoxin-induced uveitis. InvestOphthalmolVis Sci 2003,44:1993-1997.
[17]Yang PZ, JiL, ZhouHY, etc. Disturbed expression of Fas/FasL on CD4+ and CD8+ T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome and Idiopathic anterior uveitis. Ocul Immunol Inflamma,2001,9:185-191.
[18]Yang PZ, Chen L, Zhou HY, etc.Resistance of lymphocytes to Fas-mediated apoptosis in Behcet's disease and Vogt-Koyanagi-Harada syndrome. Ocul Immunol Inflamma, 2002.10：47-52.
[19]杨培增.葡萄膜炎的研究进展[J].中华眼科杂志,2005,41：1149-1151
[20]杨培增.葡萄膜炎免疫治疗的进展与展望[J].中华眼科杂志,2002,38：574-576
[21]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454-455.
[22]陈丽芳.中药为主治疗色素膜炎[J].中国中医眼科杂志.1993.3：78
[23]徐先耀.中西医综合治疗葡萄膜炎疗效观察[J].中西医结合眼科,1986；5(4)：3
[24]周先贡.中西医综合治疗葡萄膜炎疗效观察[J].中西医结合眼科,1986.6(4)：23
[25]杨培增.准确诊断和合理治疗葡萄膜炎[J].中华眼科杂志,2004,40：505-506
[26]郭霞.蔡华松治疗色素膜炎经验[J].山东中医药大学学报,1998,22(6)：454-455.
[27]庞凤,郑新青.中西医结合治疗特殊类型葡萄膜炎36例临床分析[J].山东中医药大学学报,2002,26(2)：118-119.
[28]张红,巢国俊,庄曾渊.辩证治疗全葡萄膜炎并发渗出性视网膜脱离2例[J].中国中药眼科杂志,2002,12(3)：169-169.
[29]许立军,陈少军,何春燕,等.竹叶石膏汤加减预防葡萄膜炎治疗中的激素反跳现象[J].中西医结合眼科杂志,1997,15(3)：133-134
[30]赵桂霞.半夏泻心汤治疗葡萄膜炎的体会[J].中国中医眼科杂志,2000,10(2)：113-114
[31]郭霞,吕璐,刘玲,等.抗炎明目袋泡剂治疗慢性葡萄膜炎临床研究[J].山东中医药大学学报,2001,25(4)：256
[32]徐大梅,吕海江.清肝利湿汤治疗急性前葡萄膜炎100例[J].中医研究,1998,11(5)：22-23.
[33]崔文治.复明冲剂对急性葡萄膜炎患者视野的影响[J].中国中医眼科杂志,1999,11(9)：13-16.
[34]胡士星,李绍珍,谢楚芳,等.清开灵对T淋巴细胞有丝分裂反应的影响[J].中国实验免疫学杂志,1992,4：45-47
[35]刘晶晶,崔浩,傅少颖,等.应用中药熏眼治疗前葡萄膜炎的临床观察[J].伤残医学杂志,2004,12(4)：22-23
[36]孙虹,孟亚泉,王素兰.针灸联合扩瞳治疗虹膜睫状体炎疗效观察[J].现代中西医结合杂志,2004,13(24)：3278-3279
[37]张铭端,等.白芍总贰对内因性葡萄膜炎患者的免疫调节作用[J].中华眼底病杂志,1994,10(3)：14
[38]蔡桂英.雷公藤治疗慢性色素膜炎[J].中西医结合眼科杂志,1997,15(3)：140-141
[39]马翠萍,杨培增,钟晖,等.汉防已碱对实验性葡萄膜炎的抑制作用[J].中山大学学报(医学科学版),2003,24(1)：74-76
[40]杨培增,王红,周红颜,等.葡萄膜炎药物治疗中的问题分析[J].中华眼科杂志,2004,40(10)：679-682.
[41]杨培增,李绍珍,谢楚芳.Behet病的现代药物治疗.中华眼底病杂志,1994,10：138-141.
[42]杨培增,著.临床葡萄膜炎[M].北京：人民卫生出版社,2004.33-178,107-210.
[43]K tter I, Zierhut M, Eckstein AK, etc. Human recombinant interferon alfa-2a for the treatment of Behcet's disease with sight threatening posteriororpanuveitis. Br JOphthalmol.2003,87:423-431.
[44]JosephA, Raj D, Dua HS, etc. Infliximab in the treatment of refractory posterioruveitis. Ophthalmology,2003,110:1449-1453.
[45]FosterCS, VitaleAT. Immunosuprressive chemotherapy. In:Foster CS, Vital AT, eds. Diagnosis and treatment of uveitis.Philadelphia:WB Saunders,2002.177-214.
[46]Tacrolimus (FK506) in the treatment ofposterior uveitis refratory to cyclosporine. Ophthalmology,1999,106:723-728.
[47]Thurau SR, W ildnerG Oral tolerance for treating uveitis-new hope for an old immunologicalme chanism. Prog Retin Eye Res,2002,21:577-589.