基于IHE的医学影像协作网的构建研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
区域卫生信息协同系统的建设是大规模、多系统集成的研究课题,包括了集成技术和各类技术和信息标准的使用问题。近年来,以互联网为代表的新一代信息技术已经广泛地渗透到人们的日常生活中,网络上各种信息的互操作已经成为各行个业共同研究课题。医疗卫生服务行业也毫无例外,作为世界经济体系中最大的行业之一,正在经受着现代信息生活方式的巨大改变所带来的前所未有的挑战。与其他信息密集型服务型产业部门,如银行金融、工程通讯、新闻媒介、商品销售相比,医疗卫生部门的信息化程度,特别是信息处理的标准化程度与不同信息源之间的信息交换及兼容程度,处于较为落后的状况。近几年的研究表明,国内外专家们一致认为在当前医疗健康信息海量增长的环境下,只有通过广泛采用以电子病历为核心现代医疗信息技术,将彼此相互分割的各医疗信息系统有机地连接起来,建立基于通用的信息标准、以共享为目标的医疗卫生信息网络,才能促成异构系统问数据信息的相互交换和医疗卫生服务领域整体变革的实现,促进国家医疗改革中有序医疗的实现,满足人们对医疗服务质量与方式不断更新的需求。
     随着IT技术的发展逐渐能够支撑起各行业集成应用,中间件技术、HIS集成技术等也开始引入医疗信息化并且得到了一定程度的应用。DICOM和HL7解决了医学影像信息化中的互联问题,但是由于标准之间存在着差异以及针对的数据处理对象不同,所以实现图像与文字系统之间的集成等方面仍存在较多的问题。HIMSS和RSNA从1999年开始着手定制基于DICOM和HL7标准的IHE。IHE的目的在于解决医疗行业中软硬件间的沟通问题,为信息的整合提供流程导向的标准架构,它从一个高层次定义和规范了不同医疗信息系统在不同医院和不同部门间相互连接和集成的问题,给RIS/PACS的信息流程和工作流程带来了规范化的文档指引。基于逐渐发展成熟的技术基础,2004年,IHE制定了解决互操作性问题的规范——“跨机构文档共享规范(Cross-Enterprise DocumentSharing,XDS)”,以解决区域性的医疗信息共享问题。XDS主要为医疗机构之间文档共享的管理提供一个规范,这些医疗企业可以包括私人诊所和门诊部甚至是一个住院病人的紧急看护科室。目前,IHE解决互操作性的一组规范包括PIX(病人ID交叉索引)、XDG(跨机构文档共享)、XDS-I(跨机构图像信息文档共享)等一系列规范,已经成为医学信息共享标准的基础规范。该规范得到世界各国医疗行业人士的公认,国际上许多的国家和地区的基于该规范设计本土区域医疗卫生信息系统的体系结构。
     IHE及医疗卫生信息的共享在我国的研究应用较其它国家而言较为滞后。作者认为,造成这种现状的因素是多样的,主要体现在几点上。一是国内医疗信息化行业缺乏组织性,各自为营,没有从长远的角度来考虑病人信息的共享问题;二是国内医疗信息化产品虽数目众多,但大都局限于对某个产品功能上研究应用,对国际标准的采用鲜有,忽略了日后系统整合和数据信息共享的需求,先天的形成数据源及信息系统异构性,为将来医疗卫生信息区域化再次产生资源的共享和互操作上的不便;三是缺乏一个标准化的框架来指引信息的共享流程,形成了各地区或研究机构相互独立的“信息孤岛”现象;四是医疗机构的决策者对于医疗信息共享的不够重视,仅将信息化理解成“手工流程”的取代,未能深刻理解到医疗信息在共享方面带来的医疗服务水平的提升的可能性,只重视内部应用,不重视与外界的交流沟通。
     面对差距与需求,本文试图通过参照IHE实现医疗工作流程的优化和信息的共享,提出适合我国医疗信息化特点的医疗卫生信息共享方式,探索符合当前医疗改革趋势的医疗信息化模式的发展道路。医学影像检查是病人诊断的重要依据之一,作者关注到如果能将不同医院的RIS/PACS连接在一起,让医生能随时获取病人的历史病历,就能更有效的利用这些电子资源提高诊治的有效性。然而,在现实应用中这些系统往往是独立的,RIS/PACS一般只能接受和保存自己的数据,并不具有对外开外数据的能力。同时,这些数据的保存格式多样,并没有一个统一的规范和标准,这些都给医学影像信息及相关数据带来了极大的困难。随着国家区域医疗信息化的发展,各医疗机构之间信息的共享是必然的发展趋势。医学影像数据的共享作为诊断凭据的原始数据,无论从医疗价值还是技术难度和支撑环境在医疗信息共享和集成中都是必须高度重视和首先突破的。研究过程中作者与其他国家在HIT方面所作的工作进行分析对比,希望能学习和借鉴国外成功经验的同时避免其间的某些失误,实现跨越式发展。
     本文在研究的基础上,提出了基于IHE医学影像协作网的构建方法,希望通过一个第三方的平台,组成一个医学影像协作网内的医疗联盟,在遵循国际IHE规范的条件下,纳入需要资源共享的医疗机构,突破地理位置的局限性,在网内实现病人资源的规范性共享和互操作性,更有效的支持对病人的医疗服务以及医学影像相关科研及医学教育的应用,实现医疗服务机构和科研教育机构的利益最大化。与一般的区域性PACS不同的是,医学影像协作网可以比区域性PACS具有更广泛的应用范围,允许各类异构但符合国际标准的信息系统接入其中,应用上更关注的协作网内各组织之间的协作,侧重于工作流、沟通交流、信息的集成共享等方面。
     本文总结了医学影像信息化环境的特点,在IHE技术框架下根据本土医院操作的实际流程,构建了放射科的工作流模式,并对涉及的互操作性关键问题做了分析和实现的研究。本文重点研究了医学影像协作网平台的构建和其中实现异构系统间互操作性的技术。医学影像协作网互操作性的实现需要建立在独立的RIS/PACS系统高度集成与IHE规范化的基础上。本文互操作的对象主要是病人ID相关信息,DICOM影像、报告和相关的文档。以往的医疗信息系统一般采用封闭的私有协议和基于C/S的系统架构,带来的问题是开放性、互操作性和扩展性的不足,为了联入更多的医院和用户,需要很大的软件开发工作量。随着软件工程技术的发展,以Web service为基础的SOA架构已经走向成熟,以其优良的可扩展、互操作、可复用的优势在各类软件系统的研发中逐步占据重要地位。根据医学影像协作网跨平台的分布式综合应用特点,我们采用SOA的架构,应用了Web Services和.NET等计算机前沿技术。研究的关键技术包括放射科IHE工作流模式的研究、基于IHE XDS和XDS-I的跨院文档流程的设计和传输设计,基于IHE PIX的病人ID交叉索引技术研究,基于广域网的DICOM影像传输研究等。
     本研究的特色与创新主要有:
     1.基于.NET的web service SOA开放式标准架构的医学影像协作网平台。现有的区域性PACS或类似的共享平台一般采用集成的存储方式,C/S或C/S与B/S结合的方式,开放性、互操作性和扩展性不足,当新的用户要求加入时,需要单独进行集成开发,成本高昂。以Web service为基础的SOA架构在跨医院、跨区域、跨平台的分布式综合应用比传统的方式更具灵活性。
     2.跨平台的病人ID交叉索引。病人ID的识别是医疗机构基础性的工作,在国内长期以来得不到重视,导致数据建立的标准不统一,各地区医院间系统形形色色,难以实现集成和共享。病人ID在跨院跨平台时的共享是各类系统集成时极为复杂的问题,该技术问题的解决对医疗集团和区域卫生信息系统的发展意义重大。本研究基于IHE PIX集成规范,采用开放的协议和系统架构,在多个产生病人标识符的应用中,实现病人标识的交叉引用,也就是将不同应用系统中的病人ID进行匹配,建立跨系统的病人ID检索系统。这种方式简化病人ID管理,减少出错的机会。
     3.实现基于开放式标准的跨院跨平台的医学影像及相关文档的无缝共享。在大多数医院的信息系统中,病人的医疗文档大部分是非结构化的自由文本的形式,实现共享十分的困难。本研究采用标准通用的协议、结构化的方式来封装处理医疗文档,结合病人ID共享的索引系统自动搜索病人的在线注册文档资料,实现了病人信息在网络上的无缝集成,消除了病人信息在多家医院中形成的“信息孤岛”。
The constitution of regional healthcare information system is a large-scaled, multi-system integration research, which is involved in all of the integration technologies and standards. In recent years, the new generation of information technologies, typically, the Internet, has wildly and deeply touched every corner of people's daily life. The interoperability of various kinds of information has been the focus of all industries and service departments. Healthcare service industries, as the biggest and primary domain of world economic system, is facing the challenges from the modern lifestyle. Comparing with other information-intensive industries, such as bank financial, engineering communications, media, merchandise sales, the degree of information in healthcare industry always falls behind them. In recent years, studies show that both domestic and foreign experts agreed that with the massive increase of the healthcare information, we should widespread adoption electronic medical records at the core of modern medical information technology, to meet the demand of the information interoperability in different system. To reach the goal for information share, the new healthcare network should be built on the common information standards. Then the data between heterogeneous systems can be exchange and reused based on the communication. This contributes to the regional healthcare services to achieve. In addition, these methods help the healthcare reform policy in our national, especially for the realization of healthcare services in an orderly manner and the solution for the structural imbalance between healthcare resources and patients.
     With the development of IT technology, now it can support the integration of applications from various industries. Middleware technology and HIS integration technology have been introduced in healthcare industry. DICOM and HL7 have solve a problem about connection between heterogeneous systems in the Internet, but there are still more problems to realize interoperability. Due to the difference between the standard and data processing objects, so the integration for the systems against image and text will be more trouble. Integrating the Healthcare Enterprise (IHE) is an initiative designed to stimulate the integration of the information systems that support modern healthcare institutions. It was stared in 1999 by RSNA and HIMSS. Its fundamental objective is to ensure that in the care of patients all required information for medical decisions is both correct and available to healthcare professionals. The approach employed in the IHE initiative is to support the use of existing standards, e.g HL7, ASTM, DICOM, ISO, IETF, OASIS and others as appropriate, rather than to define new standards. Especially, it defines several profiles for the implementation of established messaging standards to achieve interoperability in 2004, which mainly includes XDS, XDS-I. The effect of IHE is recognized around the world. In Many international countries and regions, the design of regional healthcare systems be considered to comply with IHE.
     The research on IHE and the sharing of healthcare information in China is lagging behind other countries for many reasons. First, the developing of healthcare information is Lack of organizational. There is no long-term perspective to consider the issue of patients' information sharing. Second, although the products of healthcare information are numerous, but just a few of them was designed by standards inadequately, which ignores the need of information systems integration and data sharing in the future. Third, the absence of a standardization framework to guide the information sharing processes leads to 'information islands'. Fourth, decision-makers for medical institutions pay not enough attention to the sharing of healthcare information. They believe that information is just a replace of 'manual process' on computer and refuse to communicate with other healthcare institutes.
     This research aims to achieve healthcare information sharing and medical business workflow optimization by reference to IHE. We put forward the methods to sharing healthcare information suited to the medical business characteristics in china. The patterns of healthcare information development is discussed in the current healthcare reform trends. Medical imaging is one of an important basis for the diagnosis of patients, so the PACS acts as an important role in medical business. When a patient transfers to different hospital, the Clinicians desires to access all of the patient's healthcare intonations including the document outside there own hospital. They hope to connect the RIS/PACS in different institutions to improve the rate of diagnostic accuracy .But it is difficult to do for heterogeneous systems and heterogeneous data formats. With the development of regional healthcare information, information sharing between medical institutions has become an inevitable trend. So medical images as the raw data for diagnosis are required to share at any time when clinicians need. It is worth to do efforts on this research. We analysis the use of HIT in other countries in the course of study and hope to learn from the successful experience of foreign countries to avoid the errors they have done.
     This paper proposes the means to construct a medical image coordinating system based on IHE for information sharing. We hope that through a third-party platform we can organize a collaborative network of medical imaging medical Union in accordance with IHE. The healthcare institutions admit to the union and share resources to break through the limitations of geographical location by network. Then we will reach the goal of information sharing and interoperability by internet. Simultaneously the system can provide medical education service and medical imaging-related research service based the data sharing. Compared with regional PACS carried out in many cities of china., it is widely used and allows heterogeneous systems to participate. In the other hand, it gives more attention on the collaboration in the union which aims to data integration.
     This paper summarizes the characters of medical imaging environment, and builds a radiology workflow model under the IHE technical framework in accordance with the actual process of local hospital in china. What's more, the key issues of interoperability between different applications are discussed and used on the system to some extend. If the RIS/PACS have been highly integrated, it will easy the realization of interoperability in the medical image coordinating system. This approach is related to many legacy hospital systems. These systems usually take private protocol and C/S architecture. Then many problems emerge when we require to share the data from them, such as Openness, interoperability and scalability. With the development of software engineering, Web service-based SOA architecture has been mature and good enough to give a help to HIT for its advantages such as scalable, interoperable, reusable. In fact, a series of potential advantages and innovations can be identified for such an approach. (1)The use of patient identifier cross-referencing. The patient ID cross-referencing is the basic of the document sharing of the system. But the IDs are different in hospitals for the same person. So it is significant to identify the patient and mach the information. (2)The system is based on .NET and web service-base SOA. In terms of tele-diagnostics of medical imaging, this way is much better than the legacy systems. (3) by the use of MTOM, we promote the performance of medical image files transmission on web and share the medical image and related documents seamlessly.
引文
1.文峰,顾强,朱兆丰.PACS在放射科管理中的应用初探.现代医用影像学,2008,17(3):105-107
    2.中国医院信息化发展研究报告,2008
    3.美国HIMSS协会2006年医院信息化现状调查
    4.陈诺夫,谭祖春,苏永林.关于整合和联合应用区域卫生资源的几点思考.西南军医,2008,10(2):137-138
    5.陈智生,陈金雄,余轮.基于HL7标准与中间件技术集成方法的信息化平台.特别策划,2006,10(8):6-8
    6.王世威,吕旭东,许茂盛.基于IHE技术框架实现工作流集成.中国医学计算机成像杂志,2007,13(1):63-67
    7.李玉杰,熊文举,姜浩娜.基于SOA架构的医院信息系统集成.中国数字医学,2008,3(8):54-56
    8.蔡晋龙,陈金雄.基于集成平台的医院信息系统集成方案.中国医疗器械杂志,2007,31(6):419-421
    9.郑然,金海,章勤.基于网格的医疗信息集成及图像处理应用.华中科技大学学报(自然科学版),2007,35(sup.2):117-120
    10.杨媛媛,孙健永,张凯.基于网格及IHE XDS/XDS-I技术框架和协议的区域影像电子健康记录系统的设计与实现.中国生物医学工程学报,2008,27(2):191-198
    11.刘丽华,周丹,金水高.面向医院管理者的HIS信息集成与应用服务设计.中国医院,2006,10(11):59-61
    12.柴鹏飞,郑裕青,陈玉平.浅析桐庐县区域卫生信息系统建设方案.现代医院,2008,8(5):146-148
    13.江一民,杜兆辉,孟仲莹.区域卫生信息共享模式的探索研究.中国数字医学,2008,3(8):21-23
    14.李华才.区域卫生信息化建设任重道远访中国医院协会信息管理专业委员会常务副主任委员李包罗.中国数字医学,2008,3(1):13-14
    15.余元龙等.论医院信息化建设对原有工作流程的改变.中国卫生,2003,7:59-60
    16.樊小玲.区域卫生信息资源开发利用模式的建立与应用.中国数字医学,2008,3(4):10-13
    17.张义,张鹭鹭,扈长茂.区域卫生资源分布优化建模.第二军医大学学报,2005,26(11):1224-1225
    18.彭想,陈敏.区域医疗卫生信息共享的类型及内容.中国医院院长,01 091:43-45
    19.吕旭东,段会龙,王曦.现有系统扩展IHE集成功能的设计方法.中国生物医学工程学报,2008,27(1):76-81
    20.高波,查志琴,郑成增.医保系统异构软件集成实现的研究.常州工学院学报,2007,20(1):9-12
    21.包国峰,秦成勇,杨兵.医疗应用集成平台的研究.医学信息学,2007,20(1):10-12
    22.王骏.影响PACS的相关因素.医疗卫生装备,2005,26(11):41-44
    23.董建华.走向互操作的中国医疗信息网络-议如何借鉴美国经验加快发展过程.中国数字医学杂志,2007,2(7):9-20
    24.田军章,张雪林,江桂华.影像诊断结构化报告的临床应用优势.中国组织工程研究与临床康,2007,11(5):850-853
    25.贾冬焱,徐元胜.DICOM MPPS的原理及应用.中国医疗器械信息,2006,12(7):65-68
    26.陈鎏 张建国.DICOM结构化报告技术.红外,2003,11(月刊):23-31
    27.孙凯,汤韦华,吕晓辉.RIS与PACS集成中worklist功能的实现.中国医学装备,2005,2(11):43-44
    28.辛海燕,黄燕.Worklist在医学影像系统的作用和实现.中国数字医学,2008,2(8):41-44
    29.杨小燕,郭文明.基于B/S架构的DICOM结构化报告的设计与应用.中国医学物理学杂志,2006,23(5):370-372转383
    30.田军章,张雪林,江桂华.基于医学影像存储与传输系统的结构化报告模块的设计与实现.中华放射学杂志,2004,38(5):539-542
    31.伏光莲,杨延成,董守华.结构化报告的设计与开发.北京生物医学工程,2006,25(3):304-306
    32.田军章,张雪林,江桂华.数据挖掘在医学影像储存与传输系统结构化报告中的应用.中国临床康复,2006,10(45):108-110
    33.罗敏,彭承琳,王小林.通过工作列表实现数字化网络各系统之间患者信息的一致性.中华放射学杂志,2003,37(5):472-474
    34.杜先懋,李澄.医学影像存储与传输系统中结构化报告的初步应用研究[J].中华放射学杂志,2005,39(4):428-431.
    35.端妮.南方医科大学博士学位论文.基于Web Service的远程医学影像协作平台的研究,2007
    36.严静东.南方医科大学博士学位论文.数字医学影像存储网格关键技术研究,2007
    37.刘谦.区域性医学影像信息系统的实现策略[J].中国医疗器械信息,2008,14(5):36-38
    38.苏锦梅,郭平.区域医疗网络案例研究[J].中国数字医学,2007年07期:21-24
    39.陶勇浩,IHE-集成医疗卫生企业,世界医疗器械,2005
    40.钟国康 陈星荣.医疗信息系统集成的进展[J].中国医学计算机成像杂志.2004,10(4):281-283
    41.http://www.ihe.net/
    42.标准化基本术语第一部分:GB3935.1-83,中国标准化综合研究所,1984
    43.www.gartner.com
    44.www.hl7.org
    45.http://www.rsna.org/IHE/index.shtml
    46.http://www.agilelabs.cn/blogs/linldn/archive/2006/04/22/1029.aspx
    47.郑俊辉,许雷.Web Service与CORBA的比较及分析[J].西南民族大学学报自然科学版.2005,31(1):134-137
    48.储晓阳,黄庆丰,黄邻彬.PACS在我院应用的现状和发展对策之探讨[J].医疗装备.2008,16(8):26-27
    49.王光华,谢长生.医学影像存档与通讯系统中存储系统分析[J].医学信息,2005,18(11):1111-1113.
    50.Marco Beltrame,Pierpaolo Bosazzi,Davide Cicuta.challenges and original solutions in developing an open source project for the PACS critical system.Int J CARS,DOI 10.1007/s 11548-008-0252-3
    51.Luke E.Wilkinson,MSc and Sam R.Gledhill,BSc.An Integrated Approach to a Teaching File Linked to PACS.Journal of Digital Imaging,2007,20(4):402-410
    52.W.Khaliq,C.J.Blakeley,S.Maheshwaran.Comparison of a PACS Workstation with Laser Hard Copies for Detecting Scaphoid Fractures in the Emergency Department.Journal of Digital Imaging,doi:10.1007/s10278-008-9165-5
    53.Gustavo S.P.Meirelles,Peter Kijewski,Ph.D,Timothy Akhurst,M.D.Correlation of PET/CT Standardized Uptake Value Measurements Between Dedicated Workstations and a PACS-Integrated Workstation System.Journal of Digital Imaging,2007,20(3):307-313
    54.Bj(o|¨)rn Bergh.Enterprise imaging and multi-departmental PACS.Eur Radiol,(2006)16:2775-2791
    55.Ebba Helmrot,H(?)kan Pettersson,Michael Sandborg.Estimation of dose to the unborn child at diagnostic X-ray examinations based on data registered in RIS/PACS.Eur Radiol,(2007) 17:205-209
    56.Vincent Rev(?)ret,Philippe Andr(?),Michel Talvard.HERSCHEL-PACS Bolometer Arrays for Submillimeter Ground-Based Telescopes.J Low Temp Phys(2008) 151:32-39
    57.Shuji Sakai,Hidetake Yabuuchi,Yoshio Matsuo.Integration of Temporal Subtraction and Nodule Detection System for Digital Chest Radiographs into Picture Archiving and Communication System (PACS) Four-year Experience.Journal of Digital Imaging,2008,21 (1):91-98
    58.Petter Hurlen,Truls 0stbye,Arne Borthne.Introducing PACS to the Late Majority.A Longitudinal Study.Journal of Digital Imaging,doi:10.1007/s10278-008-9160-x
    59.Steve Langer.Issues Surrounding PACS Archiving to External,Third-Party DICOM Archives.Journal of Digital Imaging,doi:10.1007/s10278-008-9125-0
    60.Philippe Duyck,Bram Pynoo,Pieter Devolder.Monitoring the PACS Implementation Process in a Large University Hospital—Discrepancies Between Radiologists and Physicians.Journal of Digital Imaging,doi:10.1007/s10278-008-9163-7
    61.P.Devolder,B.Pynoo,T.Voet.Optimizing Physicians' Instruction of PACS Through E-Learning-Cognitive Load Theory Applied.Journal of Digital Imaging,doi:10.1007/s10278-007-9089-5
    62.Moritz T,Brandstaetter J,Tiani M.Pacs-Beyond Radiology and E-learning.Int J CARS,2008,3 (Suppl 1):S164-S168
    63.G.Graschew,T.A.Roelofs,S.Rakowsky.PACS Beyond radiology.Int J CARS,2007,2 (Suppl 1):S326-S329
    64.C.Bongardo,P.M.Andreani,K.Okumura.Simulations of galactic cosmic ray impacts on the Herschel/PACS bolometer arrays with Geant4 code.Exp Astron (2008)22:109-128
    65.Dong Keun Kim,Sun K.Yoo,Jeong Jin Park.PDA-Phone-Based Instant Transmission of Radiological Images over a CDMA Network by Combining the PACS Screen with a Bluetooth-Interfaced Local Wireless Link.Journal of Digital Imaging,2007,20(2):131-139
    66.P.B.Marthinsen,J.Hald,R.Bergstram.Regional Pacs and Telemedicine.Int J CARS (2008) 3 (Suppl 1):S155-S163
    67.Uwe Engelmanna,H.Munch,A.Schro.The last 10 years of evolution in teleradiology:an overview of concepts and approaches of CHILL,Int J CARS (2007) 2 (Suppl 1):S315-S325
    68.O.Abri,M.Neubauer,M.Schonherr.Process oriented integration of an operating room in minimally invasive surgery:enabling medical HiTech developments for efficient every day use in hospitals.hat J CARS(2007) 2(Suppl 1):S427-S444
    70.Kent Fridell,Lars Edgren,Lars Lindskold.The Impact of PACS on Radiologists_ Work Practice.Journal of Digital Imaging,2007,20(4):411-421
    71.Jonathan Mates,Barton F.Branstetter,Matthew B.Morgan.'Wet Reads'in the Age of PACS:Technical and Workflow Considerations for a Preliminary Report System.Journal of Digital Imaging,2007,20(3):296-306
    72.Carney,D.;Smith,J.;& Place,P.Topics in Interoperability:Infrastructure Replacement in a System of Systems Pittsburgh,PA:Software Engineering Institute,Carnegie Mellon University
    73.杨小燕,郭文明,陈光杰.放射科工作流程标准化的临床应用研究.实用放射学
    74.张海,杨小燕,郭文明.基于XML的DICOM SR信息模型的研究.中国医学物理学杂志.2006,23(7):276-279
    75.http://www.moh.gov.cn/publicfiles/business/htmlfiles/mohbgt/s6690/200902/39201.htm.卫生部新闻办公室.
    76.http://se.csai.cn/Monograph/200611141116331889.htm
    77.魏东,陈晓江,房鼎益.基于SOA体系结构的软件开发方法研究[J].微电子学与计算机,2005,22(6):73-76

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700