河南沈丘县HIV感染者和AIDS患者的营养状况调查
摘要
目的
了解河南沈丘县HIV感染者和AIDS患者的营养现状和营养需求,为进一步实施营养干预收集基线资料。
方法
按随机化原则从健康者(采用血清检测方法筛选未受HIV感染)、HIV感染者和AIDS患者,抽取正常对照组30人、HIV感染者40人和AIDS患者组44人,共计114人。对各组被调查者进行营养状况问卷调查、体格测试和实验室检测,采用统计软件分析比较各组人群的膳食营养素摄入量,了解其膳食构成和健康状况。
结果
1.三组调查对象的食物摄入中,谷类和蛋类摄入达到《中国居民平衡膳食宝塔》(2007)推荐量,水果、蔬菜、动物性食物、豆类摄入低于推荐量,正常对照组每人每天奶类摄入量仅为10g左右,而HIV感染组和AIDS患者组没有饮奶。
2.三组调查对象的脂肪摄入不足,且脂肪供能占总能量的不足20%；蛋白质摄入量满足正常推荐量,但其中超过85%来自植物性食物。
3.三组调查对象每日人均维生素A、维生素B2、维生素C、维生素E摄入量严重不足,分别只占推荐摄入量(RNI)的30%、50%、50%和60%。
4.三组调查对象每日人均钙和锌的摄入量低于RNI的25%和65%。
5.HIV感染组和AIDS患者组血浆钙水平低于正常对照组(P<0.05),AIDS患者组血浆锌水平低于正常对照组(P<0.05)。
结论
1.三组调查对象的膳食结构均不合理,除谷类和蛋类,其他食物的摄入量,尤其是奶类均不足。
2.HIV感染组和AIDS患者组的能量、碳水化合物、脂肪和蛋白质摄入不足。
3.三组调查对象的维生素和矿物质存在不同程度的摄入不足。
4.HIV感染组和AIDS患者组血中常量元素钙和微量元素锌下降。
Objective
To investigate the nutritional status and needs among individuals infected by HIV and AIDS patients to provide the evidence for further nutritional intervention study.
Methods
The healthy people came from people who were not affected by HIV screened through serum test. A total of30healthy people aged30～60years old were randomly selected as the control group, and40individuals with HIV infection and44AIDS patients were randomly selected as HIV infection group and AIDS patient group respectively. Dietary survey, physical examination and laboratory test of the subjects were carried out. The ANOVA were performed to compare the difference among three groups by use of SPSS12.0. The statistics standard was a=0.05.
Results
1. The amount of cereal and eggs reached the level recommended in "the dietary guideline and Dietary Pagoda for Chinese Resident in2007", while the intake of the other food, especially milk, were insufficient. The HIV and AIDS patients did not intake milk.
2. The fat intake of the subjects in three groups was not enough, which could not meet20%of the total of energy; the protein intake of the subjects in three groups met the normal need, but more than85%of it came from plant food.
3. The daily intake of vitamin A, vitamin C, vitamin B2, and vitamin E were less than30%,50%,50%, and65%of recommended nutrients intake (RNI) respectively.
4. The daily consumption of calcium and zinc of the subjects in three groups were less than25%RNI and65%RNI respectively.
5. The serum calcium levels of subjects in HIV and AIDS groups were lower than that in control group(P<0.05); and the serum zinc levels of subjects in AIDS group was lower than that in control group(P<0.05), too.
Conclusions
1. The dietary structure of the subjects in three groups was not suitable, and the intake of milk should be increased.
2. The total energy of the subjects in HIV and AIDS groups was not enough, which should be reasonably increased.
3. The daily intake of vitamin and mineral of the subjects was insufficient, which could be supplied by vegetable and fruit and some animal food.
4. The serum calcium and zinc levels of subjects in AIDS groups and the serum calcium level in HIV group were seriously lower than that in control group.
了解河南沈丘县HIV感染者和AIDS患者的营养现状和营养需求,为进一步实施营养干预收集基线资料。
方法
按随机化原则从健康者(采用血清检测方法筛选未受HIV感染)、HIV感染者和AIDS患者,抽取正常对照组30人、HIV感染者40人和AIDS患者组44人,共计114人。对各组被调查者进行营养状况问卷调查、体格测试和实验室检测,采用统计软件分析比较各组人群的膳食营养素摄入量,了解其膳食构成和健康状况。
结果
1.三组调查对象的食物摄入中,谷类和蛋类摄入达到《中国居民平衡膳食宝塔》(2007)推荐量,水果、蔬菜、动物性食物、豆类摄入低于推荐量,正常对照组每人每天奶类摄入量仅为10g左右,而HIV感染组和AIDS患者组没有饮奶。
2.三组调查对象的脂肪摄入不足,且脂肪供能占总能量的不足20%；蛋白质摄入量满足正常推荐量,但其中超过85%来自植物性食物。
3.三组调查对象每日人均维生素A、维生素B2、维生素C、维生素E摄入量严重不足,分别只占推荐摄入量(RNI)的30%、50%、50%和60%。
4.三组调查对象每日人均钙和锌的摄入量低于RNI的25%和65%。
5.HIV感染组和AIDS患者组血浆钙水平低于正常对照组(P<0.05),AIDS患者组血浆锌水平低于正常对照组(P<0.05)。
结论
1.三组调查对象的膳食结构均不合理,除谷类和蛋类,其他食物的摄入量,尤其是奶类均不足。
2.HIV感染组和AIDS患者组的能量、碳水化合物、脂肪和蛋白质摄入不足。
3.三组调查对象的维生素和矿物质存在不同程度的摄入不足。
4.HIV感染组和AIDS患者组血中常量元素钙和微量元素锌下降。
Objective
To investigate the nutritional status and needs among individuals infected by HIV and AIDS patients to provide the evidence for further nutritional intervention study.
Methods
The healthy people came from people who were not affected by HIV screened through serum test. A total of30healthy people aged30～60years old were randomly selected as the control group, and40individuals with HIV infection and44AIDS patients were randomly selected as HIV infection group and AIDS patient group respectively. Dietary survey, physical examination and laboratory test of the subjects were carried out. The ANOVA were performed to compare the difference among three groups by use of SPSS12.0. The statistics standard was a=0.05.
Results
1. The amount of cereal and eggs reached the level recommended in "the dietary guideline and Dietary Pagoda for Chinese Resident in2007", while the intake of the other food, especially milk, were insufficient. The HIV and AIDS patients did not intake milk.
2. The fat intake of the subjects in three groups was not enough, which could not meet20%of the total of energy; the protein intake of the subjects in three groups met the normal need, but more than85%of it came from plant food.
3. The daily intake of vitamin A, vitamin C, vitamin B2, and vitamin E were less than30%,50%,50%, and65%of recommended nutrients intake (RNI) respectively.
4. The daily consumption of calcium and zinc of the subjects in three groups were less than25%RNI and65%RNI respectively.
5. The serum calcium levels of subjects in HIV and AIDS groups were lower than that in control group(P<0.05); and the serum zinc levels of subjects in AIDS group was lower than that in control group(P<0.05), too.
Conclusions
1. The dietary structure of the subjects in three groups was not suitable, and the intake of milk should be increased.
2. The total energy of the subjects in HIV and AIDS groups was not enough, which should be reasonably increased.
3. The daily intake of vitamin and mineral of the subjects was insufficient, which could be supplied by vegetable and fruit and some animal food.
4. The serum calcium and zinc levels of subjects in AIDS groups and the serum calcium level in HIV group were seriously lower than that in control group.
引文
[1]束莉,博庆丽,李李.阜阳市艾滋病感染者/病人的营养知识、态度及饮食行为调查[J].现代预防医学,2009,136(9)：1619～1623
[2]王文芝.健康教育对AIDS患者知识与行为方而的影响[J].中国科学,2010,38(5)：724～726
[3]徐春华.农村HIV感染者/AIDS病人对营养知识晓状况及干预效果评价[J].河南职工医学院学报,201(),22(1)：49～51
[4]刘爱玲.关于艾滋病防治医务人员营养知识的调查[J].中国健康教育,2004,120(15)：424～426
[5]翁田波,魏霞,蔡卫平.艾滋病合并消耗综合征的营养治疗疗效观察[J].实用医学杂志,2009,25(3)：413～414
[6]Nemechek PM, Polsky B, Gottlieb MS. Treatment guidelines for HIV-associated wasting[J].Mayo Clin Proc,2000,75(4):386～3941
[7]Fields-Gardner C. Nutrition intervention in the care of persons with human immunodeficiency virus infection-posit ion of the ADA and the Canada dietitians association[J].J Am Diet Assoc,1994,94:1042～ 10451
[8]李娟娟,万青青,郑克勤.营养干预与艾滋病防治[J].皮肤病与性病,2009,31(1)：19～22
[9]戴芬,梁雪梅,敖小敏.艾滋病患者的饮食宣教[J].医疗论坛,2011,03：1165～1166
[10]孙长颢.营养与食品卫生学(第6版)[M].北京：人民卫生出版社,2007：213
[11]中国营养学会.中国居民膳食营养素参考摄入量[J].营养学报,2001,23(3)：193～200
[12]杜丽群,李新萍,韦彩云.营养支持疗法对AIDS患者营养状况的干预效果研究[J].护士进修杂志,2008,23(16)：1486～1488
[13]Jain VK, Chandra RK. Does nutritional deficiency predispose to acquired deficiency syndrome[J].Nutr Res,1984,4:537～543
[14]Beisel WR. Nutrition and immune function; Overview[J].J Nutr,1996,126:2611～2615
[15]崔嵛.牛奶是健康膳食的基石[J].中国教育报,2008,8：1
[16]Wong C. W.牛奶蛋白的免疫潜能[J].中国兽医杂志,1999,25(1)：48～49
[17]朱新义,朱言蹊,许世禄.农村HIV感染者/AIDS病人膳食营养宣教效果评价[J].中国艾滋病性病.2010,16(8)：579～581
[18]Stack JA, Bell SJ, Burk e PA, et al.. High-energy, high-protein, oral liquid, nutrition supplementation in patients with HIV infection:effect on weight status in relation to incidence of secondary infection[J]J Am Diet Assoc,1996,96 (4):337～341
[19]Alessandro Federico, Elena D'Aiuto, Francesco Borriello. Fat:A matter of disturbance for the immune system[J].World J Gastroenterol,2010,16(38):4762～4772
[20]孟海南.维生素A(VA)与人体健康的关系[J].饮料工业,2011,117(10)：19～23
[21]袁旭鹏,陈立祥,陈志云.维生素A与免疫[J].应用研究,2010,6：23～24
[22]马维江,杨文学.人体免疫与膳食调配[J],扬州大学烹饪学报,2004,1：23～26
[23]解丽君,赵松,郝娜.锌和维生素A对乙醇致大鼠睾丸损伤的保护作用[J].河北医药,2010.32(11)：1349～1351
[24]周占琴,武和平,付明哲.反刍家畜营养免疫学研究进展[J].1999～2000年全国养羊生产与学术研讨会议论文集,2010,23：33-36
[25]Tang AM, Graham NM, Semba, et al. Association between serum vitamin A and E levels and HIV-1 disease progression[J].AIDS,1997,11(5):124～126
[26]Lai H, Lai S, Shor-Posner G, et al. Plasma zinc, copper, copper:zinc ratio, and survival in a cohort of HIV-1-infected homosexual men[J].J Aquir Immune Dific Syndr Humm Retrovirol,2001,27(1):56～62
[27]张日俊,周毓平,黄燕,等.锌对肉仔鸡免疫器官生长发育及免疫功能调节作用的研究[J].畜牧兽医学报,1999,14(2)：113～115
[28]盛晓阳,薛敏波,沈理笑,等.小剂量补锌剂对学龄前儿童血清锌水平及细胞免疫功能的影响[J].临床儿科杂志,2002,20(4)：221～2233
[29]Fawzi W, Msamanga G, Spiegelman D, et al. Studies of vitamins and minerals and HIV transmission and disease progression[J].J Nutr,2005,135(4):938-944
[30]黄玉华.艾滋病病人营养失调的原因分析及护理[J].护理研究,2004,18(2)：252
[31]许萱荷,杜丽群,苏春雄.艾滋病病人营养不良的原因分析及及护理[JJ].现代医药卫生,2007,233(141)：2159～2160
[32]Sauerwein H.P艾滋病人营养耗竭[J].中国临床营养杂志,2001,9(2)：87～88
[33]田均平,姚金朋,余卫.男性HIV相关脂肪营养不良综合征患者骨矿含量DXA测量结果浅析[J].中华骨质疏松和骨矿盐疾病杂志,2010,3(3)：164-167
[34]张明志,于宏林,赵昇皓.钙结合蛋白CaBP-72免疫特性的研究[J].河北医药,2010,32(11)：73～74
[35]刘英,程翔,廖玉华.钙通道阻滞剂与心血管免疫炎症的关系[J].中国药理学通报,2007,23(2)：141～144
[36]Beck K.W, Schramel P, Hedl A, et al. Trace element concentrations in HIV infected patients[J].Oncologie, 1989,12:43～47
[37]Graham NM, Sorensen D, Odaka N, et al. Relationship of serum cooper and zinc level to HIV-1 seropositivity and progression to AIDS [J].Acquir Immune Defic Syndr,1991,4:976～980
[38]郭松超,普力,孙斌.HIV感染者血清中4种微量元素含量分析[J].中国公共卫,2007,23(9)：1054～1055
[39]王永会,王绮,安晓肖.锌和艾滋病自愿咨询检测及其在艾滋病防治工作中的作用[J].医学研究与教育,2009,26(4)：64-66
[1]束莉,博庆丽,李李.阜阳市艾滋病感染者/病人的营养知识、态度及饮食行为调查[J].现代预防医学,2009,36(9)：1619～1623
[2]王文芝.健康教育对AIDS患者知识与行为方面的影响[J].中国科学,2010,38(5)：724～726
[3]杜建伟,聂绍发.艾滋病流行因素及干预措施研究进展[J].中国热带医学,2008,8(7)：1249～1251
[4]杨秀卿.艾滋病流行状况和控制措施.应用预防医学[J].2008,z1：24～28
[5]Brookmeyer R. Measuring the HIV/AIDS epidemic:approaches and challenges[J].Epidemiol Rev,2010, 32(1):26-37
[6]李延军.艾滋病流行趋势及预防策略和措施[J].长春大学学报,2007,17(2)：61～65
[7]邓国姣.艾滋病流行现状与控制措施[J].应用预防医学,2010,(16)：49～52
[8]何浩岚,雷春亮,唐小平,等HIV/AIDS病人264例的流行病学及临床特征分析[J].世界感染杂志,2005：5(3)：189～192
[9]Germain A.Women and the global AIDS epidemic[J].Lancet,2009,373(9663):544-566
[10]葛可佑.中国营养科学全书[M].北京：人民卫生出版社,2004：127～238
[11]杨绍基,任红.传染病学[M].第七版,北京：人民卫生出版社,2006：116～117
[12]Gray RT, Heymer KJ, Hoare A. What impact might the economic crisis have on HIV epidemics in Southeast Asia[J]. Curr HIVRes,2009,7(6):656～665
[13]Jain VK, Chandra RK. Does nutritional deficiency predispose to acquired deficiency syndrome[J].Nutr Res,1984,4:537～543
[14]Brookmeyer R. Measuring the HIV/AIDS epidemic:approaches and challenges[J]. Epidemiol Rev,2010. 32(1):26～37.
[15]Ajayi AO, Ajayi EA, Fasakin KA. CD4- T-Lymphocytes cell counts in adults with human immunodeficiency virus infection at the medical depart of a tertiary health institution in Nigeria[J].Ann Afr Med,2009,8(4):257～260
[16]Tisoncik J.R, Belisle S.E, Diamond D.L et al. Is systems biology the key to preventing the next pandemic? [J]. Future Virol, 2009,4(6):553～561.
[17]Schenk K.D, Michaelis A, Sapiano T.N, et al. Improving the lives of vulnerable children:implications of Horizons research among orphans and other children affected by AIDS[J]. Public Health Rep,2010. 125(2):325～336
[18]Faintuch J, Soeters PB, Osmo HG. Nutritional and metabolic abnormalities in pre-AIDS HIV infection[J]. Nutrition,2006,22(6):683～690
[19]Bloem M.W, Saadeh R. The role of nutrition and food insecurity in HIV and tuberculosis infections and the implications for interventions in resource-limited settings[J]. Foreword Food Nutr Bull,2010.31(4): 89-91
[20]陈丽珠,汪亚玲.营养支持治疗对艾滋病患者生化指标的影响[J].国际检验医学杂志,2007,28(12)：1143～1146
[21]Burnett, R.J, Reents S.B. Severe hypomagnesemia induced by pentamidine[J]. DICP,1990,24(3): 239～40
[22]Beck KW, Schramel P, Hedl A, et al. Trace element concentrations in HIV infected patients[J].Oncologie, 1989,12:43～47
[23]Graham NM, Sorensen D, Odaka N, et al. Relationship of serum cooper and zinc leverl to HIV-1 seropositivity and progression to AIDS [J].Acquir Immune Defic Syndr,1991,4:976～980
[24]刘爱玲.关于艾滋病防治医务人员营养知识的调查[J].中国健康教育,2004,120(15)：424～426
[25]孙长颢.营养与食品卫生学[M].6版.北京：人民卫生出版社,2007
[26]李娟娟,万青青,郑克勤.营养干预与艾滋病防治[J].皮肤病与性病,2009,31(1)：19～22
[27]Jain VK, Chandra RK. Does nutritional deficiency predispose to acquired deficiency syndrome[J].Nutr Res,1984,4:537～543
[28]Beisel WR. Nutrion and immune function; Overview[J].J Nutr,1996,126:2611～2615
[29]郭松超,普力,孙斌.HIV感染者血清中4种微量元素含量分析[J].中国公共卫,2007,23(9)：1054～1055
[30]Chandra RK. Nutrition and immunology from clinic to cellular biology and back again[J].Proc Nutr soc, 1999,58:681～683
[31]Suttajit M. Advances in nutrition support for quality of life in HIV/AIDS[J].Asia Pac J Clin Nutr,2007, 16:318-322
[32]Faulk WP, Demaeye EM, Davis AJS. Some effects of malnutrition on the immune response in man[J].Am J Clin Nutr,1974,27:638～646
[33]李强,谢小军,罗毅平,等.饲料淀粉水平对南方鲇免疫的影响[J].水生生物学报,2007,31(4)：557～562
[34]Stack JA, Bell SJ, Burk e PA, et al. High-energy, high-protein, oral liquid, nutrition supplementation in patients with HIV infection:effect on weight status in relation to incidence of secondary infection[I].J Am Diet Assoc.1996,96 (4):337～341
[35]郑纪山,唐祖明,周宗安,等.蛋白质营养不良对小鼠免疫状态的影响[J].南京部队医药,2000,2(5)：7～10
[36]谢红.运动员营养对免疫力及运动能力的影响[J].体育世界·学术,2006,4：13～14
[37]季成叶,刘宝林.儿童少年卫生学[M].6版.北京：人民卫生出版社,2011：32～38
[38]Jayarajan P, Reddy V, Mohanram M. Effect of dietary fat on absorption of β-carotene from green leafy vegetables in children[J].Indian Journal of Medical Research,1980,71:53～56.
[39]李云甫,周庆安,刘文刚,等.脂类在动物营养中的作用与研究进展[J].中国医学杂志,2009,26(6)：84～87
[40]Arminio A, Sabin CA, Phillips AN, et al. Cardio-and cerebrovascular events in HIV-infected persons[J].AIDS,2004,18:1811-1817
[41]Friis-Meller N, Sabin CA, Weber R, et al. Combination antiretroviral therapy and the risk of myocardial infarction[J]J Med,2003,349:1993～2003
[42]孟海南.维生素A(VA)与人体健康的关系[J].饮料工业,2011,117(10)：19～23
[43]袁旭鹏,陈立祥,陈志云.维生素A与免疫[J].应用研究,2010,6：23～24
[44]马维江,杨文学.人体免疫与膳食调配[J].扬州大学烹饪学报,2004,1：23～26
[45]Blomhoff R, Green MH, Green JB, et al. Vitamin A metabolism:new perspectives on absorption, transport, and storage[J].Physiological Reviews,1991,71:951～990
[46]周占琴,武和平,付明哲.反刍家畜营养免疫学研究进展[J].1999～2000年全国养羊 生产与学术研讨会议论文集,2010,23：33～36
[47]陈志云,袁旭鹏,陈立祥.维生素A与免疫.湖南饲料[J].2010(6)：23～24
[48]Beisel WR营养与免疫功能[J].国外医学卫生学分册,1997,24(4)：241～243
[49]Lyn Patrick. Nutrients and HIV:part two-vitamins A and E, zinc, B-vitamins, and magnesium[J].Altern Med Rev,2000,5(1):39～51
[50]陈雷,安军,郭海燕,等.维生素B2在家禽养殖中的应用[J].饲料研究,2010,11：：37～38
[51]赵秀花,杨海明,王志跃.营养物质对鸡免疫功能的影响[J].山地农业生物学报,2004.23(2)：164～168.
[52]邱荣斌,吴发兴.不同剂量维生素C对蛋鸡免疫机能的影响[J].动物医学进展,2009,30(11)：72～75
[53]李思明,欧阳玲花,韦启鹏, 等.维生素D对动物免疫细胞的调节作用[J].江西农业学报,2011,23(12)：147～149
[54]杭雁.维生素D对人免疫功能影响的研究[J].内蒙古医学院学报,2010,32(1)：43-46
[55]祁晓平,黎介寿.1,25-二羟维生素D3对Th1优势应答大鼠免疫功能的影响[J].解放军医学杂志,2006,31(11)：1053～1055
[56]Boonstra A, Barrat FJ, Crain C, et al 1 alpha,25-Dihydroxyvitamin D3 has a direct effect on native CD4(+)T cells to enhance the development of Th2 cells[J]. J Immunol,2001,167(9):4974～4980
[57]袁国华,罗雄燕,吴凤霞,等.维生素D与自身免疫性疾病[J].中华临床免疫和变态反应杂志,2010,4(4)：312～316
[58]史新娥,龚月生.维生素E对鸡免疫功能的影响畜禽业[J].2005,(10)：38～39
[59]郑麦青,韩慕俊,赵桂苹.维生素E对蛋鸡血清皮质酮浓度的影响[J].饲料研究,2009,8：7～9
[60]付弘赞,李吕木.矿物质对动物营养与免疫的影响[J].饲料工业,2006,27(8)：49～51
[61]张文众,崔文明,刘泽嵌,等.多种维生素矿物质补充剂对小鼠免疫功能的影响[J].中国临床营养杂志,2005.13(5)：259～262
[62]章沙沙,刘素纯,刘仲华,等.部分维生素和矿物质调节机体免疫系统的作用机制研究进展[J].中国食物与营养,2009(7)：50-53
[63]吴建设,呙于明.微量元素铜的营养与免疫研究进展[J].国外畜牧科技,1999,26(1)：67～69.
[64]解丽君,赵松,郝娜.锌和维生素A对乙醇致大鼠睾丸损伤的保护作用[J].河北医药,2010,32(11)：1349～1351
[65]Scrimgeour AG, Condlin ML. Zinc and micronutrient combinations to combat gastrointestinal inflammation[J].Curr Opin Clin Nutr Metab Care,2009,12(6):653～660
[66]Kassu A, Yabutani T. Serum zinc, copper, selenium, calcium, and magnesium levels in pregnant and non-pregnant woman in Gondar, Northwest[J].Ethiopia.Biol Trace Elem Res,2008,22(2):97～106
[67]罗绪,王刚.饲粮铬对热应激肉仔鸡免疫功能的影响[J].营养学报,2002,24(3)：286～291
[68]Beck MA, Levander OA. Dietary oxidative stress and the potentiation of viral infection[J].Annu Rev Nutr. 2003,18(2):93-116
[69]Nemechek PM, Polsky B, Gottlieb MS. Treatment guidelines for HIV-associated wasting[J].Mayo Clin Proc,2000,75(4):386～3941
[70]Mahungu TW, Rodger AJ, Johnson MA. HIV as a chronic disease[J].Clin Med,2009,9(2):125～128
[71]Fields-Gardner C. Nutrition intervention in the care of persons with human immunodeficiency virus infect ion-posit ion of the ADA and the Canada dietitians association[J].J Am Diet Assoc,1994,94:1042～ 10451
[72]戴芬,梁雪梅,敖小敏.艾滋病患者的饮食宣教[J].医疗论坛,2011,03：1165～1166
[73]Serrano C, Laporte R, Ide M. Family nutrition support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country[J]..Asia Pac J Clin Nutr,2010,19(1): 68-75
[74]马冠生,刘爱玲,胡小琪,等.艾滋病病毒感染者和病人的营养调查[J].中国食物与营养,2003,10：48～50
[75]Wheeler DA. Weight loss and disease progression in HIV infection[J].AIDS Read,1999,9(5):347～353
[2]王文芝.健康教育对AIDS患者知识与行为方而的影响[J].中国科学,2010,38(5)：724～726
[3]徐春华.农村HIV感染者/AIDS病人对营养知识晓状况及干预效果评价[J].河南职工医学院学报,201(),22(1)：49～51
[4]刘爱玲.关于艾滋病防治医务人员营养知识的调查[J].中国健康教育,2004,120(15)：424～426
[5]翁田波,魏霞,蔡卫平.艾滋病合并消耗综合征的营养治疗疗效观察[J].实用医学杂志,2009,25(3)：413～414
[6]Nemechek PM, Polsky B, Gottlieb MS. Treatment guidelines for HIV-associated wasting[J].Mayo Clin Proc,2000,75(4):386～3941
[7]Fields-Gardner C. Nutrition intervention in the care of persons with human immunodeficiency virus infection-posit ion of the ADA and the Canada dietitians association[J].J Am Diet Assoc,1994,94:1042～ 10451
[8]李娟娟,万青青,郑克勤.营养干预与艾滋病防治[J].皮肤病与性病,2009,31(1)：19～22
[9]戴芬,梁雪梅,敖小敏.艾滋病患者的饮食宣教[J].医疗论坛,2011,03：1165～1166
[10]孙长颢.营养与食品卫生学(第6版)[M].北京：人民卫生出版社,2007：213
[11]中国营养学会.中国居民膳食营养素参考摄入量[J].营养学报,2001,23(3)：193～200
[12]杜丽群,李新萍,韦彩云.营养支持疗法对AIDS患者营养状况的干预效果研究[J].护士进修杂志,2008,23(16)：1486～1488
[13]Jain VK, Chandra RK. Does nutritional deficiency predispose to acquired deficiency syndrome[J].Nutr Res,1984,4:537～543
[14]Beisel WR. Nutrition and immune function; Overview[J].J Nutr,1996,126:2611～2615
[15]崔嵛.牛奶是健康膳食的基石[J].中国教育报,2008,8：1
[16]Wong C. W.牛奶蛋白的免疫潜能[J].中国兽医杂志,1999,25(1)：48～49
[17]朱新义,朱言蹊,许世禄.农村HIV感染者/AIDS病人膳食营养宣教效果评价[J].中国艾滋病性病.2010,16(8)：579～581
[18]Stack JA, Bell SJ, Burk e PA, et al.. High-energy, high-protein, oral liquid, nutrition supplementation in patients with HIV infection:effect on weight status in relation to incidence of secondary infection[J]J Am Diet Assoc,1996,96 (4):337～341
[19]Alessandro Federico, Elena D'Aiuto, Francesco Borriello. Fat:A matter of disturbance for the immune system[J].World J Gastroenterol,2010,16(38):4762～4772
[20]孟海南.维生素A(VA)与人体健康的关系[J].饮料工业,2011,117(10)：19～23
[21]袁旭鹏,陈立祥,陈志云.维生素A与免疫[J].应用研究,2010,6：23～24
[22]马维江,杨文学.人体免疫与膳食调配[J],扬州大学烹饪学报,2004,1：23～26
[23]解丽君,赵松,郝娜.锌和维生素A对乙醇致大鼠睾丸损伤的保护作用[J].河北医药,2010.32(11)：1349～1351
[24]周占琴,武和平,付明哲.反刍家畜营养免疫学研究进展[J].1999～2000年全国养羊生产与学术研讨会议论文集,2010,23：33-36
[25]Tang AM, Graham NM, Semba, et al. Association between serum vitamin A and E levels and HIV-1 disease progression[J].AIDS,1997,11(5):124～126
[26]Lai H, Lai S, Shor-Posner G, et al. Plasma zinc, copper, copper:zinc ratio, and survival in a cohort of HIV-1-infected homosexual men[J].J Aquir Immune Dific Syndr Humm Retrovirol,2001,27(1):56～62
[27]张日俊,周毓平,黄燕,等.锌对肉仔鸡免疫器官生长发育及免疫功能调节作用的研究[J].畜牧兽医学报,1999,14(2)：113～115
[28]盛晓阳,薛敏波,沈理笑,等.小剂量补锌剂对学龄前儿童血清锌水平及细胞免疫功能的影响[J].临床儿科杂志,2002,20(4)：221～2233
[29]Fawzi W, Msamanga G, Spiegelman D, et al. Studies of vitamins and minerals and HIV transmission and disease progression[J].J Nutr,2005,135(4):938-944
[30]黄玉华.艾滋病病人营养失调的原因分析及护理[J].护理研究,2004,18(2)：252
[31]许萱荷,杜丽群,苏春雄.艾滋病病人营养不良的原因分析及及护理[JJ].现代医药卫生,2007,233(141)：2159～2160
[32]Sauerwein H.P艾滋病人营养耗竭[J].中国临床营养杂志,2001,9(2)：87～88
[33]田均平,姚金朋,余卫.男性HIV相关脂肪营养不良综合征患者骨矿含量DXA测量结果浅析[J].中华骨质疏松和骨矿盐疾病杂志,2010,3(3)：164-167
[34]张明志,于宏林,赵昇皓.钙结合蛋白CaBP-72免疫特性的研究[J].河北医药,2010,32(11)：73～74
[35]刘英,程翔,廖玉华.钙通道阻滞剂与心血管免疫炎症的关系[J].中国药理学通报,2007,23(2)：141～144
[36]Beck K.W, Schramel P, Hedl A, et al. Trace element concentrations in HIV infected patients[J].Oncologie, 1989,12:43～47
[37]Graham NM, Sorensen D, Odaka N, et al. Relationship of serum cooper and zinc level to HIV-1 seropositivity and progression to AIDS [J].Acquir Immune Defic Syndr,1991,4:976～980
[38]郭松超,普力,孙斌.HIV感染者血清中4种微量元素含量分析[J].中国公共卫,2007,23(9)：1054～1055
[39]王永会,王绮,安晓肖.锌和艾滋病自愿咨询检测及其在艾滋病防治工作中的作用[J].医学研究与教育,2009,26(4)：64-66
[1]束莉,博庆丽,李李.阜阳市艾滋病感染者/病人的营养知识、态度及饮食行为调查[J].现代预防医学,2009,36(9)：1619～1623
[2]王文芝.健康教育对AIDS患者知识与行为方面的影响[J].中国科学,2010,38(5)：724～726
[3]杜建伟,聂绍发.艾滋病流行因素及干预措施研究进展[J].中国热带医学,2008,8(7)：1249～1251
[4]杨秀卿.艾滋病流行状况和控制措施.应用预防医学[J].2008,z1：24～28
[5]Brookmeyer R. Measuring the HIV/AIDS epidemic:approaches and challenges[J].Epidemiol Rev,2010, 32(1):26-37
[6]李延军.艾滋病流行趋势及预防策略和措施[J].长春大学学报,2007,17(2)：61～65
[7]邓国姣.艾滋病流行现状与控制措施[J].应用预防医学,2010,(16)：49～52
[8]何浩岚,雷春亮,唐小平,等HIV/AIDS病人264例的流行病学及临床特征分析[J].世界感染杂志,2005：5(3)：189～192
[9]Germain A.Women and the global AIDS epidemic[J].Lancet,2009,373(9663):544-566
[10]葛可佑.中国营养科学全书[M].北京：人民卫生出版社,2004：127～238
[11]杨绍基,任红.传染病学[M].第七版,北京：人民卫生出版社,2006：116～117
[12]Gray RT, Heymer KJ, Hoare A. What impact might the economic crisis have on HIV epidemics in Southeast Asia[J]. Curr HIVRes,2009,7(6):656～665
[13]Jain VK, Chandra RK. Does nutritional deficiency predispose to acquired deficiency syndrome[J].Nutr Res,1984,4:537～543
[14]Brookmeyer R. Measuring the HIV/AIDS epidemic:approaches and challenges[J]. Epidemiol Rev,2010. 32(1):26～37.
[15]Ajayi AO, Ajayi EA, Fasakin KA. CD4- T-Lymphocytes cell counts in adults with human immunodeficiency virus infection at the medical depart of a tertiary health institution in Nigeria[J].Ann Afr Med,2009,8(4):257～260
[16]Tisoncik J.R, Belisle S.E, Diamond D.L et al. Is systems biology the key to preventing the next pandemic? [J]. Future Virol, 2009,4(6):553～561.
[17]Schenk K.D, Michaelis A, Sapiano T.N, et al. Improving the lives of vulnerable children:implications of Horizons research among orphans and other children affected by AIDS[J]. Public Health Rep,2010. 125(2):325～336
[18]Faintuch J, Soeters PB, Osmo HG. Nutritional and metabolic abnormalities in pre-AIDS HIV infection[J]. Nutrition,2006,22(6):683～690
[19]Bloem M.W, Saadeh R. The role of nutrition and food insecurity in HIV and tuberculosis infections and the implications for interventions in resource-limited settings[J]. Foreword Food Nutr Bull,2010.31(4): 89-91
[20]陈丽珠,汪亚玲.营养支持治疗对艾滋病患者生化指标的影响[J].国际检验医学杂志,2007,28(12)：1143～1146
[21]Burnett, R.J, Reents S.B. Severe hypomagnesemia induced by pentamidine[J]. DICP,1990,24(3): 239～40
[22]Beck KW, Schramel P, Hedl A, et al. Trace element concentrations in HIV infected patients[J].Oncologie, 1989,12:43～47
[23]Graham NM, Sorensen D, Odaka N, et al. Relationship of serum cooper and zinc leverl to HIV-1 seropositivity and progression to AIDS [J].Acquir Immune Defic Syndr,1991,4:976～980
[24]刘爱玲.关于艾滋病防治医务人员营养知识的调查[J].中国健康教育,2004,120(15)：424～426
[25]孙长颢.营养与食品卫生学[M].6版.北京：人民卫生出版社,2007
[26]李娟娟,万青青,郑克勤.营养干预与艾滋病防治[J].皮肤病与性病,2009,31(1)：19～22
[27]Jain VK, Chandra RK. Does nutritional deficiency predispose to acquired deficiency syndrome[J].Nutr Res,1984,4:537～543
[28]Beisel WR. Nutrion and immune function; Overview[J].J Nutr,1996,126:2611～2615
[29]郭松超,普力,孙斌.HIV感染者血清中4种微量元素含量分析[J].中国公共卫,2007,23(9)：1054～1055
[30]Chandra RK. Nutrition and immunology from clinic to cellular biology and back again[J].Proc Nutr soc, 1999,58:681～683
[31]Suttajit M. Advances in nutrition support for quality of life in HIV/AIDS[J].Asia Pac J Clin Nutr,2007, 16:318-322
[32]Faulk WP, Demaeye EM, Davis AJS. Some effects of malnutrition on the immune response in man[J].Am J Clin Nutr,1974,27:638～646
[33]李强,谢小军,罗毅平,等.饲料淀粉水平对南方鲇免疫的影响[J].水生生物学报,2007,31(4)：557～562
[34]Stack JA, Bell SJ, Burk e PA, et al. High-energy, high-protein, oral liquid, nutrition supplementation in patients with HIV infection:effect on weight status in relation to incidence of secondary infection[I].J Am Diet Assoc.1996,96 (4):337～341
[35]郑纪山,唐祖明,周宗安,等.蛋白质营养不良对小鼠免疫状态的影响[J].南京部队医药,2000,2(5)：7～10
[36]谢红.运动员营养对免疫力及运动能力的影响[J].体育世界·学术,2006,4：13～14
[37]季成叶,刘宝林.儿童少年卫生学[M].6版.北京：人民卫生出版社,2011：32～38
[38]Jayarajan P, Reddy V, Mohanram M. Effect of dietary fat on absorption of β-carotene from green leafy vegetables in children[J].Indian Journal of Medical Research,1980,71:53～56.
[39]李云甫,周庆安,刘文刚,等.脂类在动物营养中的作用与研究进展[J].中国医学杂志,2009,26(6)：84～87
[40]Arminio A, Sabin CA, Phillips AN, et al. Cardio-and cerebrovascular events in HIV-infected persons[J].AIDS,2004,18:1811-1817
[41]Friis-Meller N, Sabin CA, Weber R, et al. Combination antiretroviral therapy and the risk of myocardial infarction[J]J Med,2003,349:1993～2003
[42]孟海南.维生素A(VA)与人体健康的关系[J].饮料工业,2011,117(10)：19～23
[43]袁旭鹏,陈立祥,陈志云.维生素A与免疫[J].应用研究,2010,6：23～24
[44]马维江,杨文学.人体免疫与膳食调配[J].扬州大学烹饪学报,2004,1：23～26
[45]Blomhoff R, Green MH, Green JB, et al. Vitamin A metabolism:new perspectives on absorption, transport, and storage[J].Physiological Reviews,1991,71:951～990
[46]周占琴,武和平,付明哲.反刍家畜营养免疫学研究进展[J].1999～2000年全国养羊 生产与学术研讨会议论文集,2010,23：33～36
[47]陈志云,袁旭鹏,陈立祥.维生素A与免疫.湖南饲料[J].2010(6)：23～24
[48]Beisel WR营养与免疫功能[J].国外医学卫生学分册,1997,24(4)：241～243
[49]Lyn Patrick. Nutrients and HIV:part two-vitamins A and E, zinc, B-vitamins, and magnesium[J].Altern Med Rev,2000,5(1):39～51
[50]陈雷,安军,郭海燕,等.维生素B2在家禽养殖中的应用[J].饲料研究,2010,11：：37～38
[51]赵秀花,杨海明,王志跃.营养物质对鸡免疫功能的影响[J].山地农业生物学报,2004.23(2)：164～168.
[52]邱荣斌,吴发兴.不同剂量维生素C对蛋鸡免疫机能的影响[J].动物医学进展,2009,30(11)：72～75
[53]李思明,欧阳玲花,韦启鹏, 等.维生素D对动物免疫细胞的调节作用[J].江西农业学报,2011,23(12)：147～149
[54]杭雁.维生素D对人免疫功能影响的研究[J].内蒙古医学院学报,2010,32(1)：43-46
[55]祁晓平,黎介寿.1,25-二羟维生素D3对Th1优势应答大鼠免疫功能的影响[J].解放军医学杂志,2006,31(11)：1053～1055
[56]Boonstra A, Barrat FJ, Crain C, et al 1 alpha,25-Dihydroxyvitamin D3 has a direct effect on native CD4(+)T cells to enhance the development of Th2 cells[J]. J Immunol,2001,167(9):4974～4980
[57]袁国华,罗雄燕,吴凤霞,等.维生素D与自身免疫性疾病[J].中华临床免疫和变态反应杂志,2010,4(4)：312～316
[58]史新娥,龚月生.维生素E对鸡免疫功能的影响畜禽业[J].2005,(10)：38～39
[59]郑麦青,韩慕俊,赵桂苹.维生素E对蛋鸡血清皮质酮浓度的影响[J].饲料研究,2009,8：7～9
[60]付弘赞,李吕木.矿物质对动物营养与免疫的影响[J].饲料工业,2006,27(8)：49～51
[61]张文众,崔文明,刘泽嵌,等.多种维生素矿物质补充剂对小鼠免疫功能的影响[J].中国临床营养杂志,2005.13(5)：259～262
[62]章沙沙,刘素纯,刘仲华,等.部分维生素和矿物质调节机体免疫系统的作用机制研究进展[J].中国食物与营养,2009(7)：50-53
[63]吴建设,呙于明.微量元素铜的营养与免疫研究进展[J].国外畜牧科技,1999,26(1)：67～69.
[64]解丽君,赵松,郝娜.锌和维生素A对乙醇致大鼠睾丸损伤的保护作用[J].河北医药,2010,32(11)：1349～1351
[65]Scrimgeour AG, Condlin ML. Zinc and micronutrient combinations to combat gastrointestinal inflammation[J].Curr Opin Clin Nutr Metab Care,2009,12(6):653～660
[66]Kassu A, Yabutani T. Serum zinc, copper, selenium, calcium, and magnesium levels in pregnant and non-pregnant woman in Gondar, Northwest[J].Ethiopia.Biol Trace Elem Res,2008,22(2):97～106
[67]罗绪,王刚.饲粮铬对热应激肉仔鸡免疫功能的影响[J].营养学报,2002,24(3)：286～291
[68]Beck MA, Levander OA. Dietary oxidative stress and the potentiation of viral infection[J].Annu Rev Nutr. 2003,18(2):93-116
[69]Nemechek PM, Polsky B, Gottlieb MS. Treatment guidelines for HIV-associated wasting[J].Mayo Clin Proc,2000,75(4):386～3941
[70]Mahungu TW, Rodger AJ, Johnson MA. HIV as a chronic disease[J].Clin Med,2009,9(2):125～128
[71]Fields-Gardner C. Nutrition intervention in the care of persons with human immunodeficiency virus infect ion-posit ion of the ADA and the Canada dietitians association[J].J Am Diet Assoc,1994,94:1042～ 10451
[72]戴芬,梁雪梅,敖小敏.艾滋病患者的饮食宣教[J].医疗论坛,2011,03：1165～1166
[73]Serrano C, Laporte R, Ide M. Family nutrition support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country[J]..Asia Pac J Clin Nutr,2010,19(1): 68-75
[74]马冠生,刘爱玲,胡小琪,等.艾滋病病毒感染者和病人的营养调查[J].中国食物与营养,2003,10：48～50
[75]Wheeler DA. Weight loss and disease progression in HIV infection[J].AIDS Read,1999,9(5):347～353