蔗糖基聚合物的预辐射法和酶法合成及其应用研究
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摘要
含糖聚合物是指通过不同的反应途径把糖组分引入到聚合物分子链中而形成的高分子聚合物。蔗糖基聚合物(Sucrose-based polymer，SBP)就是其中之一。本文采用一种新的方法——预辐射法合成蔗糖基聚合物，即蔗糖在~(60)C_o的γ射线辐照下变成了具有引发活性的活化蔗糖，离开辐射场后再和另一种单体发生聚合反应，从而生成蔗糖基聚合物。同时对蔗糖基聚合物的有机相酶催化合成法进行了初步研究。
在预辐照法中，研究了反应单体、蔗糖预辐射剂量、存放时间、温度、反应物料配比对蔗糖基聚合物的粘均相对分子量和产率的影响。研究表明，要获得适合于农业生产应用的蔗糖基聚合物，其相对分子量为6万左右，蔗糖和单体的最优聚合反应条件为：预辐射剂量1kGy、反应温度为常温20℃；反应时间15h；水、蔗糖与单体配比为5：5：1(v/w/v)。
有机相酶催化法研究表明，Novozmy-435催化己二酸二乙烯酯与蔗糖反应中具有很高的选择性，己二酸二乙烯酯主要和蔗糖的C-6和C-6′反应生成蔗糖二酯。
本文对预辐射法合成的蔗糖基聚合物在药物缓释、水果保鲜和植物生长调节剂等方面的应用进行了研究。结果表明，蔗糖基聚合物对药物缓释有较好的效果，缓释时间可达12小时左右。蔗糖基聚合物制备非诺洛芬钙缓释片的最佳实验条件是：非诺洛芬钙、蔗糖基聚合物、海藻酸钠的质量配比为1：5：3。蔗糖基聚合物作为水果保鲜剂，可以保持水果品质，有较明
Sugar-containing polymers mean that through different responses to lead to sugar polymer molecular chain group and to form macromolecular polymers. Sucrose-based polymer (SBP) is the one of them. This dissertation focuses on a new method to synthesize sucrose-based polymer (SBP) — pre-irradiation method. Sucrose crystal was pre-irradiated by γ-ray of ~(60)Co and turned into an activated form, then the activated sucrose was polymerizes directly with another monomer (e.g. acrylic acid) to yield SBP.Preliminary study on enzymatic synthesis of polymerisable vinyl sugar esters in non-aqueous media and preparation of polymers containing sugar branches.
The effects of different monomers, pre-irradiation dose, store days of pre-irradiation sucrose, reaction temperature, monomer concentration ratio to the relative molecular weight and yield of the polymers were studied. The results
在预辐照法中，研究了反应单体、蔗糖预辐射剂量、存放时间、温度、反应物料配比对蔗糖基聚合物的粘均相对分子量和产率的影响。研究表明，要获得适合于农业生产应用的蔗糖基聚合物，其相对分子量为6万左右，蔗糖和单体的最优聚合反应条件为：预辐射剂量1kGy、反应温度为常温20℃；反应时间15h；水、蔗糖与单体配比为5：5：1(v/w/v)。
有机相酶催化法研究表明，Novozmy-435催化己二酸二乙烯酯与蔗糖反应中具有很高的选择性，己二酸二乙烯酯主要和蔗糖的C-6和C-6′反应生成蔗糖二酯。
本文对预辐射法合成的蔗糖基聚合物在药物缓释、水果保鲜和植物生长调节剂等方面的应用进行了研究。结果表明，蔗糖基聚合物对药物缓释有较好的效果，缓释时间可达12小时左右。蔗糖基聚合物制备非诺洛芬钙缓释片的最佳实验条件是：非诺洛芬钙、蔗糖基聚合物、海藻酸钠的质量配比为1：5：3。蔗糖基聚合物作为水果保鲜剂，可以保持水果品质，有较明
Sugar-containing polymers mean that through different responses to lead to sugar polymer molecular chain group and to form macromolecular polymers. Sucrose-based polymer (SBP) is the one of them. This dissertation focuses on a new method to synthesize sucrose-based polymer (SBP) — pre-irradiation method. Sucrose crystal was pre-irradiated by γ-ray of ~(60)Co and turned into an activated form, then the activated sucrose was polymerizes directly with another monomer (e.g. acrylic acid) to yield SBP.Preliminary study on enzymatic synthesis of polymerisable vinyl sugar esters in non-aqueous media and preparation of polymers containing sugar branches.
The effects of different monomers, pre-irradiation dose, store days of pre-irradiation sucrose, reaction temperature, monomer concentration ratio to the relative molecular weight and yield of the polymers were studied. The results
引文
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