颈椎形状记忆椎管成形固定器的研制及基础研究
|
摘要
本研究以Ni-Ti记忆合金为材料研制一种颈椎形状记忆椎管成形固定器(CSMLP)应用于颈椎椎管扩大成形术的固定系统。方法采用颈椎后路椎管成形山羊动物模型,通过X线、CT、组织形态学、生物力学对该固定器进行评价。结果CSMLP的环抱支尖端最大应力值为25.40±1.33Mpa,其尖端回弹力为119.86±7.59N,在30℃回弹力最大,在温度达到26℃时到达平台期。CSMLP不增加手术出血量和手术时间,可提高椎管成形术后即刻屈伸活动的稳定性,骨质愈合良好,可促进椎板再造,椎管再塑形。结论CSMLP可促进椎管成形术后铰链侧的骨愈合程度;对椎板再生有支架作用,新生骨可沿其生长。CSMLP可恢复颈椎椎管的完整性,增加颈椎椎管成形术后早期颈椎的稳定性,术中可以自行抱夹、撑开椎板,其安装简便,固定牢靠,用于颈椎椎管扩大成形术是安全、快速、有效的,即时椎管扩大效果明显,CSMLP有进一步研究的价值。
To design and manufacture a new kind of cervical spinal shape memory alloy laminoplasty system. Method Evaluate the basic character of the CSMLP with electric measurement assessment and encircle strength of holding part. Establish laminoplasty animal model, two group,ODL group (9 goats) and CSMLP group (9 goats), undergoing C4-C6 laminoplasty in ODL group and the other open-door laminoplasty with CSMLP fixation. Lateral cervical spine radiographs and cervical spine CT scan were obtained preoperatively and at 1week and 12 week post-operation. After 3 goats in each group were killed at 12 weeks post-operation, histomorphological observation were performed. After 6 goats in each group were killed at 24 weeks post-operation, biomechanical testing (range of motion in flexion-extension, lateral flexion and axial rotation) was performed using pure moment loading on 30 intact cervical spinal columns, blank group(6 goats)、instant post-laminoplasty(6 goats) and instant post-laminoplasty with CSMLP fixation (6 goats). Result The maximum Stress of the CSML's holding part was 25.40±1.33Mpa, encircle strength was 119.86±7.59N. The hinged side of All specimen in CSMLP group were fused and 7of 9 in ODL group were fused also. Newly formed bone grew along CSMLP which was a frame. CSMLP could promote lamina regeneration. Instant flexion-extension range of post-operation was larger than the control group(p<0.05). Conclusions .CSMLP can open and cramp lamina automatically. It was easy to be performed and the fixation effect was stably. IThe instant cervical spine curvature and cervical spine curvature 24 weeks post-operation decreased significantly. The healing of hinged side was good by using CSMLP. Instant range of flexion- extension decreased after laminoplasty. laminoplasty increase unsteadiness at the early time post-operation. CSMLP can improve the instant stability in flexion-extension post-operation by increase the antibending section modulus. Laminoplasty did not change instant lateral flexion and axial rotation post-operation in the condition of weather use CSMLP or not. The range of motion decreased significantly medium or long period after laminoplasty in the condition of weather use CSMLP or not.
To design and manufacture a new kind of cervical spinal shape memory alloy laminoplasty system. Method Evaluate the basic character of the CSMLP with electric measurement assessment and encircle strength of holding part. Establish laminoplasty animal model, two group,ODL group (9 goats) and CSMLP group (9 goats), undergoing C4-C6 laminoplasty in ODL group and the other open-door laminoplasty with CSMLP fixation. Lateral cervical spine radiographs and cervical spine CT scan were obtained preoperatively and at 1week and 12 week post-operation. After 3 goats in each group were killed at 12 weeks post-operation, histomorphological observation were performed. After 6 goats in each group were killed at 24 weeks post-operation, biomechanical testing (range of motion in flexion-extension, lateral flexion and axial rotation) was performed using pure moment loading on 30 intact cervical spinal columns, blank group(6 goats)、instant post-laminoplasty(6 goats) and instant post-laminoplasty with CSMLP fixation (6 goats). Result The maximum Stress of the CSML's holding part was 25.40±1.33Mpa, encircle strength was 119.86±7.59N. The hinged side of All specimen in CSMLP group were fused and 7of 9 in ODL group were fused also. Newly formed bone grew along CSMLP which was a frame. CSMLP could promote lamina regeneration. Instant flexion-extension range of post-operation was larger than the control group(p<0.05). Conclusions .CSMLP can open and cramp lamina automatically. It was easy to be performed and the fixation effect was stably. IThe instant cervical spine curvature and cervical spine curvature 24 weeks post-operation decreased significantly. The healing of hinged side was good by using CSMLP. Instant range of flexion- extension decreased after laminoplasty. laminoplasty increase unsteadiness at the early time post-operation. CSMLP can improve the instant stability in flexion-extension post-operation by increase the antibending section modulus. Laminoplasty did not change instant lateral flexion and axial rotation post-operation in the condition of weather use CSMLP or not. The range of motion decreased significantly medium or long period after laminoplasty in the condition of weather use CSMLP or not.
引文
1.Hirabayashi K,Watanabe K,Wakano K,et al.Expansive open-door laminoplasty for cervical spinal stenotic myelopathy.[J].Spine,1983,8(7):693-699.
2.Hukuka S,Shichikawa K,Mochizuki T,et al.Cervical hyperostic myelopathy and its surgical treatment.[J].Rheumatologie,1981,33:78-81.
3.Itoh T,Tsuji H.Technical improvements and results of laminoplasty for compressive myelopathy in the cervical spine.[J].Spine.1985,10(8):729-736
4.Goto T,Ohata K,rakami T,et al.hydroxyapatite laminar spacers and titanium miniplates in cervical laminoplasty.[J].J Neurosurg,2002,97(Suppl 3):323-329.
5.KeisukeN.Spinous Process splitting laminoplasty using hydroxyapatite spinous process spacer.[J].Spine,1992,17(1):240-243.
6.O' Brien MF,Peterson D,Casey AT,et al.A novel technique for laminoplasty augmentation of spinal canal area using titanium miniplate stabilization:a computerized morphometric analysis.[J].Spine,1996,15,21(4):474-483
7.李义凯,圭兰塑,钟世镇,颈腰椎椎板厚度测量及意义.颈腰痛杂志 1997,18(3):155-156
8.Jiayong Liu,Nabil A.Ebraheim,et al.Preservation of the spinous process-ligament-muscle complex to prevent kyphotic deformity following laminoplasty.[J].The Spine.2007,7(1):159-164
9.Harel Deutsch,Praveen V.Mummaneni,Gerald E.Rodts,et al.Posterior Cervical haminoplasty Using a New Plating System.[J].J Spinal Disord Tech.2004,17(4):317-320
10.Montero-Ocamo C,hopez H,Salinas Rodriguez A.Effect of compressive straining on corrosion resistance of a shape memory Ni-Ti alloy in Ringer's solution.[J].J Biomed Mater Res 1996:32(4):583-591
11.杨大智,张连生,王凤庭.形状记忆合金[M].大连:大连工学院出版社,1988
12.Dai K Chu Y.Studies and applications of Ni-Ti shape memory alloys in the medicaI field in China.[J].Biomed Mater Eng 1996;6(4):233-240
13.Castleman h.S.,Mofzkin S M.,Alicandri F.P.,et al.Maler.[J].Bionmterials,1976,(10):695-731
1.赵建宁,王强,王以进,等.波形钢板固定股骨骨折的生物力学研究.[J].金陵医院学报.1999,12(1):4-5
2.戴克戎,倪诚,吴小涛,等1形状记忆锯齿臂环抱内固定器的实验研究与临床应用.[J].中华外科杂志,1994,32(10):629-631
3.徐莘香.L-梯形加压钢板固定股骨粗隆骨折的力学原理与应用.[J].中华医学杂志.1992.72(5):261-263
4.许硕贵,张春才,王家林等.镍钛聚髌器治疗髌骨骨折的电测分析.[J].上海生物医学工程,2001,22(3):14-16
5.许硕贵,张春才.天鹅记忆接骨器治疗骨折与骨不连动态记忆生物力学电测分析[J].上海生物医学工程,2001,22(3):11-13
6.Maliniak MM,Szivek JA,DeYoung DW,et al.Hydroxyapatite-coated strain gauges for long-term in vivo bone strain measure2ments[J].Appl Biomater,1993,4(2):143-148
7.Cben ZH,Su JC,Zhang CC,et al.Clinical significance of three dimensional model establishing and finite element analysis on humerus fracture.Zhongguo Linchuang Kanfu(Chin J Clin Rehabil)2002;6(24):3663-3664
8.苏佳灿,张春才,王家林等.天鹅型记忆加压接骨器记忆生物力学实验研究.中国临床康复,2003,7:2804-2805
1.Baisden J,Voo LM,Cusick JF,et al.Evaluation of cervical laminectomy and laminoplasty.A longitudinal study in the goat model.[J].Spine.1999;24:1283-1288;discussion 1288-1289
2.Pintar FA,Maiman DJ,Hollowell JP,et al.Fusion rate and biomechanical stiffness of hydroxylapatite versus autogenous bone grafts for anterior discectomy.An in vivo animal study.[J].Spine.1994;19:2524-2528
3.Takahashi T,Tominaga T,Watabe N,et al.Use of porous hydroxyapatite graft containing recombinant human bone morphogenetic protein-2 for cervical fusion in a caprine model.[J].J Neurosurg.1999:90:224-230
4.海涌、马华松、邹德威.应用新型合成韧带施行颈椎前路椎间融合术的实验研究.[J].中国矫形外科杂志 2002;10(11):1097-1099
5.G.P.Pal,R.V.Routal.The role of the vertebral laminae in the stability of the cervical spine.[J].J Anat.1996 April:188(Pt 2):485-489
6.Montero-Ocampo C,Lopez H,Salinas Rodriguez A.Effect of compressive straining on corrosion resistance of a shape memory Ni-Ti alloy in Ringer's solution.[J].J Biomed Mater Res 1996;32(4):583-591
1.郭世绂,陈伸欣,邱敬清,等.腰椎管骨性结构的测量与椎管狭窄.中华外科杂志,1984,22(10):623-626
2.藤村祥一,户山芳昭,柳贵裕,等.高位颈椎损伤的诊断.[J].中国脊柱脊髓杂志,1994.4(2):85-88
3.张大伟,牛广明,张建功.成人腰椎管MRI几何测量的定量研究.内蒙古医学院学报.2007,29:3172-3175
4.Dullerud R.Naksiad H.CT changes after conservative treatment for lumbar disk herniation[J].Acta Radiol,1994,35(5):415-419.
5.刘正津,陈尔瑜.1临床解剖学丛书·胸部和脊柱分册[M].北京:人民卫生出版社.1989.318-320
6..Cargill SC,Pearcy M,Barry MD.Three-dimensional lumbar spine postures measured by magnetic resonance imaging reconstruction.[J].Spine.2007,32(11):1242-1245
7.Tilson ER,Strickland GD,Gibson SD.An overview of radiography,computed tomography,and magnetic resonance imaging in the diagnosis of lumbar spine pathology[J].Orthop Nuts,2006,25(6):415-420.
8.边卫国,党晓谦,汤少杰等.计算机辅助下腰椎CT图像自动化测量及其临床价值.中国脊柱脊髓杂志.2007:17(10):749-75
1. Pal GP. Sherk HH. The vertical stability of the cervical spine. Spine, 1988, 13(5): 447
2. Jeong GK, Bendo JA. Spinal disorders in the elderly Clin Orthop Relat Res, 2004, (425): 110
3.Frank K., Georg S., Matti S. et al. Influence of cage design on interbody fusion in a sheep cervical spine model. J Neurosurg (Spine 3) 96:321-332, 2002
4. Edwards CC II, Heller JG, Silcox DH III. T-saw laminoplasty for the management of cervical spondylotic myelopathy: clinical and radiographic outcome. Spine 2000;24:1788 - 94
5. Kawai S, Sunago K, Doi K, Saka M, Taguchi T. Cervical laminoplasty (Hattori's method), procedure and follow-up results). Spine 1988:13:1245-50.
6. Seichi A, Takeshita K, Ohishi I, et al. Long-term results of double door laminoplasty for cervical stenotic myelopathy. Spine 2001;479 - 87
7. Lee T, Manazano GR, Green BA. Modified open-door cervical expansive laminoplasty for spondylotic myelopathy: operative technique, outcome, and predictors for gait improvement. J Neurosurg 1997;86:64-8
8. Kawaguchi Y, Kanamori M. Ishiara H, et al. Preventive measures for axial symptoms following cervical laminoplasty. [J]. J Spinal Disor Tech, 2003. 16(6): 497-501
1.Boden SD,Schimandle JH,Hutton WC.An experimental lumbar intertransverse process spinal fusion model.Spine 1995;20:412-420
2.Burwell RG.The function of bone marrow in the incorporation of a bone graft.Clin Orthop 1985;200:125-134
3.Kirkeby OJ.Revascularization of bone graft in rats.J Bone Joint Surg[Br]1991;73:501-5055
4.Berger-Gorbet MB,Broxup C,Rivard LH.Biocompatibility testing of NiTi screws using immunohistochemistry on sections containing metallic implants.J Biomed Mater Res.1996,32(2):243-247.
5.Yashia LH,Lombardi S,Hagemeister N,et alImprovement of cytocompatibility and biomechanical of NiTi shape memory alloys.医用生物力学 1995,10(2):19-21
6.杨贤金,梁玉,朱胜利,崔振铎.钙磷层对NiTi形状记忆合金与骨组织结合特性的影响.材料热处理学报,2002,23(1):4-6
7.Ryhlanen J,Kallioinen M,Tuukkanen J,et al.Bone modeling and cell-material interface responses induced by nickeltitanium shape memory alloy after periosteal implantaton. Biomaterials, 1999, 20: 1039-1043.
8. Ryhlanen J, Kallioinen M, Serlo W, et al. Bone healing and mineralization , implant corrosion and trace metals after nickeltitanium shape memory metal intramedullary fixation. J Biomed M ater Res, 1 999, 47: 472-477.
9.Bogdanski D, Manfred K. Dietmar M. et al. Easy assessment of the biocompatibility of NiTi alloy-s by in vitro cell culture experiments on a fun ctionally graded Ni-NiTi-Ti material. Biomaterials, 2002, 23: 4549-4554.
1.Christian M.Puttlitz Vedat Deviren Jason A.Smith.et.al.Biomechanics of cervical laminoplasty:kinetic studies comparing different surgical techniques,temporal effects and the degree of level involvement.Eur Spine J(2004) 13:213-221
2.Deutsch H,Mummaneni PV,Rodts GE,et al.Posterior cervical laminoplasty using a new plating system.J Spinal Disord Tech,2004,17(4):31-35
3.Hirabayashi K,Miyagawa J,Satomi K,et al.Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament.Spine 1981;6:354-364
4.Mochida J,Nomura T,Chiba M,et.al..Modified expansive open-door laminoplasty in cervical myelopathy.J Spinal Disord 1999;12:386-391
5.Wada E,Suzuki S,Kanazawa A,et.al.Subtotal corpectomy versus laminoplasty for multilevel cervical spondylotic myelopathy:a long-term follow-up study over 10 years.Spine 2001;26:1443-1448
6.Miyazaki K,Hirohuji E,Ono S.Extensive simultaneous multi-segmental laminectomy and posterior decompression with posterolateral fusion.J Jpn Spine Res Soc 1994;5:167-171.
7.Kimura I,Shingu H,Nasu Y.Long-term follow-up of cervical spondylotic myelopathy treated by canal-expansive laminoplasty.J Bone Joint Surg Br 1995;77:956- 961.
8.Yoshida M,Otani K,Shibasaki K,Ueda S.Expansive laminoplasty with reattachment of spinous process and extensor musculature for cervical myelopathy.Spine 1992;17:491-497.
9 Seichi A,Takeshita K,Ohishi I,et al.Long-term results of double door laminoplasty for cervical stenotic myelopathy.Spine 2001:479-487.
10.高峰,田军,单宇 等.棘突悬吊椎管扩大成形术固定效果的生物力学研究.临床骨科杂志2006 Apr;9(2)176-178
1.蔡钦林.日本颈脊髓硅压术式的新进展一颈椎管扩大术.中华骨科杂志,1987,7:152-155.
2.Surredin CE,MeAfee PC,Warden KE,et al.A biomechanical evaluation of cervical spinal stabilization methods in a bovine model:Static and cyclical loading.Spine,1988,13:795-802.
3.杨金江,王炳强,王志义,等.下颈椎单侧侧块钢板内固定的稳定性研究.颈腰痛杂志,2006,27(3):166-169.
4.Lindscy RW,Miclau T.Posterior lateral mass plate fixation of the cervical spine.J South Oahop Asso,2000,9(1):36-44.
5.Nabil Ebraheim,M.D.Posterior lateral mass screw fixation:anatomic and radiographic considerations.Orthopaedic Journal,1999,12:66-72.
6.王少波,蔡钦林,党耕町,等.单开门颈椎管扩大成形术的远期疗效观察.中华骨科杂志,1999,19(9):520-522.
7.王少波,蔡钦林,党耕町,等.颈椎管扩大术后硬膜外血肿.中华骨科杂志,1999,19(2):87-89.
8.Young Do Koh.Tae-Hong Lim,Jae Won You.M.D.et al.A biomechanical eomp,uison of modem anterior and posterior plate fixation of the cervical spine.Spine,2001,26:15-21.
9.Margaret E,Smiith MS,Maurizio Cibischino,MD,el al.A biomechanical study of a cevieal spine stab ilization device:Roy-Camille Plates.Spine,1997,22(1):38-43.
10.Oxland TR,Lund T.Biomeehanics of standalone cages and cages in combination with posterior fixation:a literature,review.Eur Spine J,2000,9(1):95-101.
11.杨雍,王炳强,李东,等.单侧短节段侧块内固定系统在颈椎病单开门减压术中的应用.颈腰痛杂志,2006,27(4):254-257.
12.王少波,蔡钦林,党耕町,等.单开门颈椎管扩大术后第5颈神经根麻痹.中华骨杂志,1999,19(12):717-720.
13.蔡钦林,党耕町,杨克勤,等.“单开门”椎管扩大术治疗颈椎管狭窄症疗效观察.中华骨科杂志,1990,10(10):325-328.
14.Spivak JM,Chen D,Kurtmaer FJ.The effect of locking fixation screws on the stability of anterior cervical plating,spine,1999,24:334-338.
15.Ryken TC,Clausen JD,Traynelis VC,et al.Biomechanical analysis of hone mieral density,insertion technique,screw torque,and holding strengh of anterior cervical plate screws.J Neurosurg,1995,83:325-329.
16.陈波,柳峰.颈椎前路单纯椎间融合器与钢板并用恢复颈椎生理曲度.中国临床康复,2003,7(8):1279-1282.
17.Coe JD,Warden KE,Stutterlin CE,et al.Biomechanical evaluation of cervical spinal stabilization mothods in human cadaveric model.Spine,1989,14:1122-1131.
18.Pair TG,al-Mefty O,Boop FA,et al.Inside-outside technique for posterior occipitocervical spine instrumentation and stabilization:preliminary rcsults.J Neurosurg Spine,1999,90:1-7.
19.Zdeblick TA,Cooke ME,Wilson D,et al.Anterior cervical discectomy,fusion and plating,spine,1993,18:1794-1783.
20.Connony PJ,Esses SI,Kostuik JP.Anterior cervical fusion:Out-come analysis of patients used with and without anterior cervical plates.J Spinal Disord,1996,9:202-206.
21.Lowery GL,McDonotlgh RF.The significance of hardware failure in anterior cervical plate fixetion.Spine.1998,23:181-186.
22.昌耘冰,尹庆水,夏虹,等.AXIS侧板钢板螺钉内固定系统对下颈椎骨折脱位后颈髓功能恢复作用.中国临床康复,2003,7(6):998-1002.
23.蒋振松,张佐伦,刘兰成.脊髓型颈椎病患者的颈椎CT测量及临床意义.中国脊柱脊髓杂志,2003,13(4):220-223.
24.Smlth MD,Emery SE,Dudley A,et al.Vertebral antery injury during anterior decompression of the cervical spine.A retrospective review of ten patients.J Bone Joira Surg Br.1993,75:410-415.
25.Ebrabeim NA,Lu J,Brown JA,et al.Vulnerability of vertebral antery in anterolateral decompression for cervical spondylosis.Clin Orthop.1996,322:146-151.
26.Pair TG,Killefer JA,Amantovic KI.Surgical anatomy of the anterior cervical spine:the disc space,vertebral antery and associated bony structures.Neurosurgery,1996,39:769-776.
27.Oga M,Yuge I,Terada K,et al.Tortuosity of the vertebral artery in patients with cervical spondylotic myelopathy:risk factor for the vertebral artery injury during anterior cervical decompression.Spine,1996,21:1085-1089.
28.Heller JG,Estes BT,Zaouall M,et al.Biomechanical study of screws in the lateral mass.vailables afecting pull-out resistance.J Bone Joint Surg Am,1996,78(9):1315-1321.
29.范少地,罗卓荆,闫自强.全椎板减压侧块内固定治疗颈椎管狭窄对脊髓神经功能恢复的临床观察.中国临床康复,2003,7(23):3264-3268.
30.Grabam AW,Swank ML,Kinard RE,et al.Posterior cervical arthradesis and stabilization with a lateral mass Plate.Spine,1996,21:323-328.
31.An MS,Gordin R,Rennet K.Anatomic considerations for plate -screw fixation of the cervical.Spine.1991,16(10):548-551.
32.徐波,金大地.下颈椎后路钢板螺钉固定的解剖学研究.中华骨科杂志,2000,20(5):279-282.
33.Pair TC,McAIlister PV,Kaufman HH.Quadrant anatomy of the articular pillars (lateral cervical mass)of the cervical spine.J Neurosurg.1995,82:1011-1014.
34.Lowery GL,Swank ML,McDonough RF,Surgical revision for failed anterior cervical fusions,Articular pillar plating or anterior revision.Spine,1995,20:2436-2441.
35.党耕町,王超,阎明,等.后路寰枢椎侧块钉板植骨融合术的临床初探.中国脊柱脊髓杂志,2003,13(1):7-10.
36.Ebraheim NA,Rupp RE,Savolaine·ER,et al.Posterior platingof the cervical spine.J Spinal Disord,1995,8:111-115.
37.Koekro Ram,Serra L,Tseng-Tsai Y,et al.Planning and simulation of neurosurgery in a virtual reality environment.Neurosurgery,2000,46:118-135.
38.钟世镇.数字人—微创外科可能结合的新技术.广东医学,2005,26(1):1-2.
39.钟世镇.数字化虚拟人体研究现状和展望.解放军医学杂志,2003,28(5):385-388.
1.赵连城等.合金的形状记忆效应与超弹性.国防工业出版社.2002.
2.郑玉峰等.生物医用镍钛台金.科学出版社.2004.
3.Frank J,Criado.Endvascular lnterve nltioa:basic concepts and techniques.Tutura Pubitshing Company.1999.
4.O.Cisse,O.Savadogo,M.Wu and L.H.Yahia.Effcet surface treatment of NiTi alloy on its corrosion behayior in Hanks solution.J Biomed Mater Res,2002.
5.赵维彪.镍钛形状记忆合金的材料学特征与医学应用.中国组织工程研究与临床康复,2007,11(22):4376-4379.
6.Machado LG,Savi MA.Medical applications of shape memory alloys.Braz J Med Biol Res,2003,36(6):683-691.
7.Kapanen A,Ilvesam J,Danilov A,et al.Behaviour of nitinol in osteoblast-like ROS-17cell cultures.Biomaterials,2002,23(3):645-650.
8.Pooh RW,Yeung KW,Liu XY,et al.Carbon plasma immersion ion implantation ofnickel-titanium shape memory alloys,Biomaterials,2005,26(15):2265-2272.
9.Bogdanski D,Koller M,Muller D,et al,Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material.Biomaterials,2002,23(23):4549-4555.
10.Kapanen A,Kinnunen A,Ryhanen J,et al.TGF-betal secretion of ROS-17/2.8 cultures on NiTi implant material.Biomaterials,2002,23(16):3341-3346.
11.Armitage DA,Parker TL,Grant DM.Biocompatibility and hemocompatibility of surface-modified NiTi alloys.Biomed Mater Res,2003,66A(1):129-137.
12.Kujala S,Ryhanen J,Jamsa T,et al.Bone modeling contmlled by a nickel-titanium shape memory alloy intramedullary nail.Biomaterials,2002,23(12):2535-2543.
13.Kapanen A,Ryhanen J,Danilov A,et al.Efieet of nickel-titanium shape memory metal alloy on bone formation.Biomaterials,2001,22(18):2475-2480.
14.Shabalovskaya SA.Surface,corrosion and biocompatibility aspects of Nitinol as an implant material.Biomed Mater Eng,2002,12(1):69-109.
15.Thierry B,Tabfizian M,Trepanier C,et al.Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy.J Biomed Mater Res,2000,51(4):685-693.
16.Firstov GS,Vitchev RG,Kumar H,et al,Suface oxidation of NiTi shape memory alloy.Biomaterials,2002,23(24):4863-4871.
17.Tan L,Dodd RA,Crone WC.Corosion and wear-corosion behavior of NiTi modified by plasma source ion implantation.Biomaterials,2003,24(22):3931-3939.
18.Choi J,Bogdanski D,Koller M,et al.Calcium phosphate coating of nickel-titanium shape-memory alloys:Coating procedure and adherence of leukccytes and platelets.Biomaterials,2003,24(21):3689-3696.
19.Knjala S,Ryhanen J,DanilovA,et al.Efect of porosity onthe osteointegration and bone ingrowth of a weight-bearing nickel-titanium bone graft substitute.Biomaterials,2003,24(25):4691-4697.
20.张春才,许硕贵,王家林,等.髋臼骨折记忆合金三维内固定系统的设计与临床应用.中华骨科杂志,2002,12(22):709-713.
21.康庆林,张春才,高堂成.天鹅记忆接骨器对长骨干骨折愈合的影响.中华骨科杂志,2004,24(2):113-118.
22.Es-Souni M,Fischer-Brandies H.On the properties of two binary Ni-Ti shape memory alloys:Effects of surface finish on the corrosion behaviour and in vitro biocompatibility.Biomaterials,2002,23(14):2887-2894.
23.Starosvetsky D,Gotman I.Corrosion behavior of titanium nitride coated Ni-Ti shape memory surgical alloy.Biomatefials.2001.22(13):1853-1859.
2.Hukuka S,Shichikawa K,Mochizuki T,et al.Cervical hyperostic myelopathy and its surgical treatment.[J].Rheumatologie,1981,33:78-81.
3.Itoh T,Tsuji H.Technical improvements and results of laminoplasty for compressive myelopathy in the cervical spine.[J].Spine.1985,10(8):729-736
4.Goto T,Ohata K,rakami T,et al.hydroxyapatite laminar spacers and titanium miniplates in cervical laminoplasty.[J].J Neurosurg,2002,97(Suppl 3):323-329.
5.KeisukeN.Spinous Process splitting laminoplasty using hydroxyapatite spinous process spacer.[J].Spine,1992,17(1):240-243.
6.O' Brien MF,Peterson D,Casey AT,et al.A novel technique for laminoplasty augmentation of spinal canal area using titanium miniplate stabilization:a computerized morphometric analysis.[J].Spine,1996,15,21(4):474-483
7.李义凯,圭兰塑,钟世镇,颈腰椎椎板厚度测量及意义.颈腰痛杂志 1997,18(3):155-156
8.Jiayong Liu,Nabil A.Ebraheim,et al.Preservation of the spinous process-ligament-muscle complex to prevent kyphotic deformity following laminoplasty.[J].The Spine.2007,7(1):159-164
9.Harel Deutsch,Praveen V.Mummaneni,Gerald E.Rodts,et al.Posterior Cervical haminoplasty Using a New Plating System.[J].J Spinal Disord Tech.2004,17(4):317-320
10.Montero-Ocamo C,hopez H,Salinas Rodriguez A.Effect of compressive straining on corrosion resistance of a shape memory Ni-Ti alloy in Ringer's solution.[J].J Biomed Mater Res 1996:32(4):583-591
11.杨大智,张连生,王凤庭.形状记忆合金[M].大连:大连工学院出版社,1988
12.Dai K Chu Y.Studies and applications of Ni-Ti shape memory alloys in the medicaI field in China.[J].Biomed Mater Eng 1996;6(4):233-240
13.Castleman h.S.,Mofzkin S M.,Alicandri F.P.,et al.Maler.[J].Bionmterials,1976,(10):695-731
1.赵建宁,王强,王以进,等.波形钢板固定股骨骨折的生物力学研究.[J].金陵医院学报.1999,12(1):4-5
2.戴克戎,倪诚,吴小涛,等1形状记忆锯齿臂环抱内固定器的实验研究与临床应用.[J].中华外科杂志,1994,32(10):629-631
3.徐莘香.L-梯形加压钢板固定股骨粗隆骨折的力学原理与应用.[J].中华医学杂志.1992.72(5):261-263
4.许硕贵,张春才,王家林等.镍钛聚髌器治疗髌骨骨折的电测分析.[J].上海生物医学工程,2001,22(3):14-16
5.许硕贵,张春才.天鹅记忆接骨器治疗骨折与骨不连动态记忆生物力学电测分析[J].上海生物医学工程,2001,22(3):11-13
6.Maliniak MM,Szivek JA,DeYoung DW,et al.Hydroxyapatite-coated strain gauges for long-term in vivo bone strain measure2ments[J].Appl Biomater,1993,4(2):143-148
7.Cben ZH,Su JC,Zhang CC,et al.Clinical significance of three dimensional model establishing and finite element analysis on humerus fracture.Zhongguo Linchuang Kanfu(Chin J Clin Rehabil)2002;6(24):3663-3664
8.苏佳灿,张春才,王家林等.天鹅型记忆加压接骨器记忆生物力学实验研究.中国临床康复,2003,7:2804-2805
1.Baisden J,Voo LM,Cusick JF,et al.Evaluation of cervical laminectomy and laminoplasty.A longitudinal study in the goat model.[J].Spine.1999;24:1283-1288;discussion 1288-1289
2.Pintar FA,Maiman DJ,Hollowell JP,et al.Fusion rate and biomechanical stiffness of hydroxylapatite versus autogenous bone grafts for anterior discectomy.An in vivo animal study.[J].Spine.1994;19:2524-2528
3.Takahashi T,Tominaga T,Watabe N,et al.Use of porous hydroxyapatite graft containing recombinant human bone morphogenetic protein-2 for cervical fusion in a caprine model.[J].J Neurosurg.1999:90:224-230
4.海涌、马华松、邹德威.应用新型合成韧带施行颈椎前路椎间融合术的实验研究.[J].中国矫形外科杂志 2002;10(11):1097-1099
5.G.P.Pal,R.V.Routal.The role of the vertebral laminae in the stability of the cervical spine.[J].J Anat.1996 April:188(Pt 2):485-489
6.Montero-Ocampo C,Lopez H,Salinas Rodriguez A.Effect of compressive straining on corrosion resistance of a shape memory Ni-Ti alloy in Ringer's solution.[J].J Biomed Mater Res 1996;32(4):583-591
1.郭世绂,陈伸欣,邱敬清,等.腰椎管骨性结构的测量与椎管狭窄.中华外科杂志,1984,22(10):623-626
2.藤村祥一,户山芳昭,柳贵裕,等.高位颈椎损伤的诊断.[J].中国脊柱脊髓杂志,1994.4(2):85-88
3.张大伟,牛广明,张建功.成人腰椎管MRI几何测量的定量研究.内蒙古医学院学报.2007,29:3172-3175
4.Dullerud R.Naksiad H.CT changes after conservative treatment for lumbar disk herniation[J].Acta Radiol,1994,35(5):415-419.
5.刘正津,陈尔瑜.1临床解剖学丛书·胸部和脊柱分册[M].北京:人民卫生出版社.1989.318-320
6..Cargill SC,Pearcy M,Barry MD.Three-dimensional lumbar spine postures measured by magnetic resonance imaging reconstruction.[J].Spine.2007,32(11):1242-1245
7.Tilson ER,Strickland GD,Gibson SD.An overview of radiography,computed tomography,and magnetic resonance imaging in the diagnosis of lumbar spine pathology[J].Orthop Nuts,2006,25(6):415-420.
8.边卫国,党晓谦,汤少杰等.计算机辅助下腰椎CT图像自动化测量及其临床价值.中国脊柱脊髓杂志.2007:17(10):749-75
1. Pal GP. Sherk HH. The vertical stability of the cervical spine. Spine, 1988, 13(5): 447
2. Jeong GK, Bendo JA. Spinal disorders in the elderly Clin Orthop Relat Res, 2004, (425): 110
3.Frank K., Georg S., Matti S. et al. Influence of cage design on interbody fusion in a sheep cervical spine model. J Neurosurg (Spine 3) 96:321-332, 2002
4. Edwards CC II, Heller JG, Silcox DH III. T-saw laminoplasty for the management of cervical spondylotic myelopathy: clinical and radiographic outcome. Spine 2000;24:1788 - 94
5. Kawai S, Sunago K, Doi K, Saka M, Taguchi T. Cervical laminoplasty (Hattori's method), procedure and follow-up results). Spine 1988:13:1245-50.
6. Seichi A, Takeshita K, Ohishi I, et al. Long-term results of double door laminoplasty for cervical stenotic myelopathy. Spine 2001;479 - 87
7. Lee T, Manazano GR, Green BA. Modified open-door cervical expansive laminoplasty for spondylotic myelopathy: operative technique, outcome, and predictors for gait improvement. J Neurosurg 1997;86:64-8
8. Kawaguchi Y, Kanamori M. Ishiara H, et al. Preventive measures for axial symptoms following cervical laminoplasty. [J]. J Spinal Disor Tech, 2003. 16(6): 497-501
1.Boden SD,Schimandle JH,Hutton WC.An experimental lumbar intertransverse process spinal fusion model.Spine 1995;20:412-420
2.Burwell RG.The function of bone marrow in the incorporation of a bone graft.Clin Orthop 1985;200:125-134
3.Kirkeby OJ.Revascularization of bone graft in rats.J Bone Joint Surg[Br]1991;73:501-5055
4.Berger-Gorbet MB,Broxup C,Rivard LH.Biocompatibility testing of NiTi screws using immunohistochemistry on sections containing metallic implants.J Biomed Mater Res.1996,32(2):243-247.
5.Yashia LH,Lombardi S,Hagemeister N,et alImprovement of cytocompatibility and biomechanical of NiTi shape memory alloys.医用生物力学 1995,10(2):19-21
6.杨贤金,梁玉,朱胜利,崔振铎.钙磷层对NiTi形状记忆合金与骨组织结合特性的影响.材料热处理学报,2002,23(1):4-6
7.Ryhlanen J,Kallioinen M,Tuukkanen J,et al.Bone modeling and cell-material interface responses induced by nickeltitanium shape memory alloy after periosteal implantaton. Biomaterials, 1999, 20: 1039-1043.
8. Ryhlanen J, Kallioinen M, Serlo W, et al. Bone healing and mineralization , implant corrosion and trace metals after nickeltitanium shape memory metal intramedullary fixation. J Biomed M ater Res, 1 999, 47: 472-477.
9.Bogdanski D, Manfred K. Dietmar M. et al. Easy assessment of the biocompatibility of NiTi alloy-s by in vitro cell culture experiments on a fun ctionally graded Ni-NiTi-Ti material. Biomaterials, 2002, 23: 4549-4554.
1.Christian M.Puttlitz Vedat Deviren Jason A.Smith.et.al.Biomechanics of cervical laminoplasty:kinetic studies comparing different surgical techniques,temporal effects and the degree of level involvement.Eur Spine J(2004) 13:213-221
2.Deutsch H,Mummaneni PV,Rodts GE,et al.Posterior cervical laminoplasty using a new plating system.J Spinal Disord Tech,2004,17(4):31-35
3.Hirabayashi K,Miyagawa J,Satomi K,et al.Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament.Spine 1981;6:354-364
4.Mochida J,Nomura T,Chiba M,et.al..Modified expansive open-door laminoplasty in cervical myelopathy.J Spinal Disord 1999;12:386-391
5.Wada E,Suzuki S,Kanazawa A,et.al.Subtotal corpectomy versus laminoplasty for multilevel cervical spondylotic myelopathy:a long-term follow-up study over 10 years.Spine 2001;26:1443-1448
6.Miyazaki K,Hirohuji E,Ono S.Extensive simultaneous multi-segmental laminectomy and posterior decompression with posterolateral fusion.J Jpn Spine Res Soc 1994;5:167-171.
7.Kimura I,Shingu H,Nasu Y.Long-term follow-up of cervical spondylotic myelopathy treated by canal-expansive laminoplasty.J Bone Joint Surg Br 1995;77:956- 961.
8.Yoshida M,Otani K,Shibasaki K,Ueda S.Expansive laminoplasty with reattachment of spinous process and extensor musculature for cervical myelopathy.Spine 1992;17:491-497.
9 Seichi A,Takeshita K,Ohishi I,et al.Long-term results of double door laminoplasty for cervical stenotic myelopathy.Spine 2001:479-487.
10.高峰,田军,单宇 等.棘突悬吊椎管扩大成形术固定效果的生物力学研究.临床骨科杂志2006 Apr;9(2)176-178
1.蔡钦林.日本颈脊髓硅压术式的新进展一颈椎管扩大术.中华骨科杂志,1987,7:152-155.
2.Surredin CE,MeAfee PC,Warden KE,et al.A biomechanical evaluation of cervical spinal stabilization methods in a bovine model:Static and cyclical loading.Spine,1988,13:795-802.
3.杨金江,王炳强,王志义,等.下颈椎单侧侧块钢板内固定的稳定性研究.颈腰痛杂志,2006,27(3):166-169.
4.Lindscy RW,Miclau T.Posterior lateral mass plate fixation of the cervical spine.J South Oahop Asso,2000,9(1):36-44.
5.Nabil Ebraheim,M.D.Posterior lateral mass screw fixation:anatomic and radiographic considerations.Orthopaedic Journal,1999,12:66-72.
6.王少波,蔡钦林,党耕町,等.单开门颈椎管扩大成形术的远期疗效观察.中华骨科杂志,1999,19(9):520-522.
7.王少波,蔡钦林,党耕町,等.颈椎管扩大术后硬膜外血肿.中华骨科杂志,1999,19(2):87-89.
8.Young Do Koh.Tae-Hong Lim,Jae Won You.M.D.et al.A biomechanical eomp,uison of modem anterior and posterior plate fixation of the cervical spine.Spine,2001,26:15-21.
9.Margaret E,Smiith MS,Maurizio Cibischino,MD,el al.A biomechanical study of a cevieal spine stab ilization device:Roy-Camille Plates.Spine,1997,22(1):38-43.
10.Oxland TR,Lund T.Biomeehanics of standalone cages and cages in combination with posterior fixation:a literature,review.Eur Spine J,2000,9(1):95-101.
11.杨雍,王炳强,李东,等.单侧短节段侧块内固定系统在颈椎病单开门减压术中的应用.颈腰痛杂志,2006,27(4):254-257.
12.王少波,蔡钦林,党耕町,等.单开门颈椎管扩大术后第5颈神经根麻痹.中华骨杂志,1999,19(12):717-720.
13.蔡钦林,党耕町,杨克勤,等.“单开门”椎管扩大术治疗颈椎管狭窄症疗效观察.中华骨科杂志,1990,10(10):325-328.
14.Spivak JM,Chen D,Kurtmaer FJ.The effect of locking fixation screws on the stability of anterior cervical plating,spine,1999,24:334-338.
15.Ryken TC,Clausen JD,Traynelis VC,et al.Biomechanical analysis of hone mieral density,insertion technique,screw torque,and holding strengh of anterior cervical plate screws.J Neurosurg,1995,83:325-329.
16.陈波,柳峰.颈椎前路单纯椎间融合器与钢板并用恢复颈椎生理曲度.中国临床康复,2003,7(8):1279-1282.
17.Coe JD,Warden KE,Stutterlin CE,et al.Biomechanical evaluation of cervical spinal stabilization mothods in human cadaveric model.Spine,1989,14:1122-1131.
18.Pair TG,al-Mefty O,Boop FA,et al.Inside-outside technique for posterior occipitocervical spine instrumentation and stabilization:preliminary rcsults.J Neurosurg Spine,1999,90:1-7.
19.Zdeblick TA,Cooke ME,Wilson D,et al.Anterior cervical discectomy,fusion and plating,spine,1993,18:1794-1783.
20.Connony PJ,Esses SI,Kostuik JP.Anterior cervical fusion:Out-come analysis of patients used with and without anterior cervical plates.J Spinal Disord,1996,9:202-206.
21.Lowery GL,McDonotlgh RF.The significance of hardware failure in anterior cervical plate fixetion.Spine.1998,23:181-186.
22.昌耘冰,尹庆水,夏虹,等.AXIS侧板钢板螺钉内固定系统对下颈椎骨折脱位后颈髓功能恢复作用.中国临床康复,2003,7(6):998-1002.
23.蒋振松,张佐伦,刘兰成.脊髓型颈椎病患者的颈椎CT测量及临床意义.中国脊柱脊髓杂志,2003,13(4):220-223.
24.Smlth MD,Emery SE,Dudley A,et al.Vertebral antery injury during anterior decompression of the cervical spine.A retrospective review of ten patients.J Bone Joira Surg Br.1993,75:410-415.
25.Ebrabeim NA,Lu J,Brown JA,et al.Vulnerability of vertebral antery in anterolateral decompression for cervical spondylosis.Clin Orthop.1996,322:146-151.
26.Pair TG,Killefer JA,Amantovic KI.Surgical anatomy of the anterior cervical spine:the disc space,vertebral antery and associated bony structures.Neurosurgery,1996,39:769-776.
27.Oga M,Yuge I,Terada K,et al.Tortuosity of the vertebral artery in patients with cervical spondylotic myelopathy:risk factor for the vertebral artery injury during anterior cervical decompression.Spine,1996,21:1085-1089.
28.Heller JG,Estes BT,Zaouall M,et al.Biomechanical study of screws in the lateral mass.vailables afecting pull-out resistance.J Bone Joint Surg Am,1996,78(9):1315-1321.
29.范少地,罗卓荆,闫自强.全椎板减压侧块内固定治疗颈椎管狭窄对脊髓神经功能恢复的临床观察.中国临床康复,2003,7(23):3264-3268.
30.Grabam AW,Swank ML,Kinard RE,et al.Posterior cervical arthradesis and stabilization with a lateral mass Plate.Spine,1996,21:323-328.
31.An MS,Gordin R,Rennet K.Anatomic considerations for plate -screw fixation of the cervical.Spine.1991,16(10):548-551.
32.徐波,金大地.下颈椎后路钢板螺钉固定的解剖学研究.中华骨科杂志,2000,20(5):279-282.
33.Pair TC,McAIlister PV,Kaufman HH.Quadrant anatomy of the articular pillars (lateral cervical mass)of the cervical spine.J Neurosurg.1995,82:1011-1014.
34.Lowery GL,Swank ML,McDonough RF,Surgical revision for failed anterior cervical fusions,Articular pillar plating or anterior revision.Spine,1995,20:2436-2441.
35.党耕町,王超,阎明,等.后路寰枢椎侧块钉板植骨融合术的临床初探.中国脊柱脊髓杂志,2003,13(1):7-10.
36.Ebraheim NA,Rupp RE,Savolaine·ER,et al.Posterior platingof the cervical spine.J Spinal Disord,1995,8:111-115.
37.Koekro Ram,Serra L,Tseng-Tsai Y,et al.Planning and simulation of neurosurgery in a virtual reality environment.Neurosurgery,2000,46:118-135.
38.钟世镇.数字人—微创外科可能结合的新技术.广东医学,2005,26(1):1-2.
39.钟世镇.数字化虚拟人体研究现状和展望.解放军医学杂志,2003,28(5):385-388.
1.赵连城等.合金的形状记忆效应与超弹性.国防工业出版社.2002.
2.郑玉峰等.生物医用镍钛台金.科学出版社.2004.
3.Frank J,Criado.Endvascular lnterve nltioa:basic concepts and techniques.Tutura Pubitshing Company.1999.
4.O.Cisse,O.Savadogo,M.Wu and L.H.Yahia.Effcet surface treatment of NiTi alloy on its corrosion behayior in Hanks solution.J Biomed Mater Res,2002.
5.赵维彪.镍钛形状记忆合金的材料学特征与医学应用.中国组织工程研究与临床康复,2007,11(22):4376-4379.
6.Machado LG,Savi MA.Medical applications of shape memory alloys.Braz J Med Biol Res,2003,36(6):683-691.
7.Kapanen A,Ilvesam J,Danilov A,et al.Behaviour of nitinol in osteoblast-like ROS-17cell cultures.Biomaterials,2002,23(3):645-650.
8.Pooh RW,Yeung KW,Liu XY,et al.Carbon plasma immersion ion implantation ofnickel-titanium shape memory alloys,Biomaterials,2005,26(15):2265-2272.
9.Bogdanski D,Koller M,Muller D,et al,Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material.Biomaterials,2002,23(23):4549-4555.
10.Kapanen A,Kinnunen A,Ryhanen J,et al.TGF-betal secretion of ROS-17/2.8 cultures on NiTi implant material.Biomaterials,2002,23(16):3341-3346.
11.Armitage DA,Parker TL,Grant DM.Biocompatibility and hemocompatibility of surface-modified NiTi alloys.Biomed Mater Res,2003,66A(1):129-137.
12.Kujala S,Ryhanen J,Jamsa T,et al.Bone modeling contmlled by a nickel-titanium shape memory alloy intramedullary nail.Biomaterials,2002,23(12):2535-2543.
13.Kapanen A,Ryhanen J,Danilov A,et al.Efieet of nickel-titanium shape memory metal alloy on bone formation.Biomaterials,2001,22(18):2475-2480.
14.Shabalovskaya SA.Surface,corrosion and biocompatibility aspects of Nitinol as an implant material.Biomed Mater Eng,2002,12(1):69-109.
15.Thierry B,Tabfizian M,Trepanier C,et al.Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy.J Biomed Mater Res,2000,51(4):685-693.
16.Firstov GS,Vitchev RG,Kumar H,et al,Suface oxidation of NiTi shape memory alloy.Biomaterials,2002,23(24):4863-4871.
17.Tan L,Dodd RA,Crone WC.Corosion and wear-corosion behavior of NiTi modified by plasma source ion implantation.Biomaterials,2003,24(22):3931-3939.
18.Choi J,Bogdanski D,Koller M,et al.Calcium phosphate coating of nickel-titanium shape-memory alloys:Coating procedure and adherence of leukccytes and platelets.Biomaterials,2003,24(21):3689-3696.
19.Knjala S,Ryhanen J,DanilovA,et al.Efect of porosity onthe osteointegration and bone ingrowth of a weight-bearing nickel-titanium bone graft substitute.Biomaterials,2003,24(25):4691-4697.
20.张春才,许硕贵,王家林,等.髋臼骨折记忆合金三维内固定系统的设计与临床应用.中华骨科杂志,2002,12(22):709-713.
21.康庆林,张春才,高堂成.天鹅记忆接骨器对长骨干骨折愈合的影响.中华骨科杂志,2004,24(2):113-118.
22.Es-Souni M,Fischer-Brandies H.On the properties of two binary Ni-Ti shape memory alloys:Effects of surface finish on the corrosion behaviour and in vitro biocompatibility.Biomaterials,2002,23(14):2887-2894.
23.Starosvetsky D,Gotman I.Corrosion behavior of titanium nitride coated Ni-Ti shape memory surgical alloy.Biomatefials.2001.22(13):1853-1859.