哈萨克族冠心病危险因素与冠状动脉病变程度的关系
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摘要
目的探讨哈萨克族患冠心病的危险因素与冠脉病变程度的关系。方法选择2002年1月-2007年5月在我院住院疑诊冠心病并行选择性冠状动脉造影检查的哈萨克族病人,对其发生冠心病的危险因素进行回顾性研究。结果选择性冠状动脉造影记录结果显示:两组间的血浆甘油三脂、糖化血红蛋白水平、高密度脂蛋白水平有显著性差异(P〈0.05)。病变组甘油三脂、糖化血红蛋白水平、年龄明显高于无病变组(P〈0.05)。两组血浆胆固醇水平无显著性差异。经回归分析表明,在哈萨克族中冠心病的病变程度与年龄(B=0.809,p= 0.005),甘油三脂具有显著回归关系(B=12.603,p= 0.000).与高密度脂蛋白水平无独立相关性(B=-4.502,p= 0.523)。与性别、高血压病程,胆固醇水平、糖尿病病程等因素无关。结论哈萨克族冠心病与高甘油三脂血症具有独立相关性。
Objective To investigate the relationship between the risk factors of coronary artery disease and the severity of the coronary artery lesions in Kazak races. Methods A total of 123 consecutively admitted Kazak races patients were studied retrospectively. All patients suspected to have coronary artery disease and underwent a selective coronary angiography and a survey of risk factors during the hospitalization. Results Through Logistic regression analysis, advanced age, HTG ,were confirmed to be independent risk factors for coronary artery disease in KAZAK races.. And course of diabetes mellitus, course of hypertension, smoking, HTC were not confirmed to have great relationship with coronary artery disease in KAZAK races from the mult iple regression analysis. Conclusions different from the Han Nationality Relationship between the risk factors of coronary artery disease and the severity of coronary artery lesions in KAZAK races were confirmed as age,HTG, increase of HbA1c in blood plasma .
Objective To investigate the relationship between the risk factors of coronary artery disease and the severity of the coronary artery lesions in Kazak races. Methods A total of 123 consecutively admitted Kazak races patients were studied retrospectively. All patients suspected to have coronary artery disease and underwent a selective coronary angiography and a survey of risk factors during the hospitalization. Results Through Logistic regression analysis, advanced age, HTG ,were confirmed to be independent risk factors for coronary artery disease in KAZAK races.. And course of diabetes mellitus, course of hypertension, smoking, HTC were not confirmed to have great relationship with coronary artery disease in KAZAK races from the mult iple regression analysis. Conclusions different from the Han Nationality Relationship between the risk factors of coronary artery disease and the severity of coronary artery lesions in KAZAK races were confirmed as age,HTG, increase of HbA1c in blood plasma .
引文
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[3] Austen W G, Edwards JE, Faye RL , et al. American heart association report: a reporting system in patients evaluated for coronary artery disease. report of the ad hoc committee for grading of coronary artery disease. Circulation, 1975, 51: 7-21.
[4]高密度质蛋白对老年人冠心病的保护作用[J]中华医学杂志2003,83(10):827—831.
[5] Mnrrugat J,Solanas P,D’Agostino R,et al.coronary risk estimation in Spain using a calibrated framingham fnuction.Rev Esp Cardiol,2003,56:253-261.
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[8]冠心病患者血浆纤维蛋白质与小而密低密度脂蛋白的关系[J]中华心血管病杂志2003,(31)8:584-587.
[9]周玲,李南方,殷晓娟,新疆牧区少数民族血脂水平调查[ J ].现代预防医学2003,30(4):529-532.
[10] Knapp R G,Sutherland S E ,Keil J E , et al . A comparison of the effects of cholesterol on CHD mortality in black and white women :twenty-eight years of follow2up in the Charleston Heart Study[J] .J Clin Epidemiol ,1992 ,45 (10) :1119-1129.
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[12] Monacci W T , Merrill M J , Oldfield E H. Expression of vascularpermeability factor/ vascular endothelial growth factor in normal rattissue[J ] . Am J Phyiol , 1993 ,264 (4) -C995.
[13] Yarnell JW,Patterson CC,Sweetnam PM,et a1.Do total and high density lipoprotein cholesterol and triglycerides act independently in the prediction of ischemic heartdisease?Ten-year follow-up of Caer-philly and Speedwell Cohorts.Arterioscler Thromb Vasc Biol,200l;21:1340-1345
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[16] Bittner V,Tripputi M,Hsia J,et a1.Remnant-like lipoproteins,hormone therapy,and anglo-graphic and clinical outcomes:The Women's An-giographic Vitamin & Estrogen Tria1.Am Heart J,2004;48(2):293-299
[17] Mahley RW, Huang YD, Rall SC Jr. Pathogene-is of type III hyperlipo- proteinemia (dysbetalipopro-teinemia):questions,quandaries,and paradoxes.J Lipid Res,1999;40:1933-1949
[18] Wang T,Nakajima K,Leary ET,et a1.Ratio of remnant-like particle-cholesterol to serum total tri-glycerides is an effective alternative to ultracentriiu-gal and electrophoretic methods in the diagnosis of familial type 11I hyperlipo- proteinemia.Clin Chem,1999;45:1981—1987
[19]陈名道.脂肪细胞产物与肥胖和代谢综合征.中华内分泌代谢杂志, 2003, 19: 161-163.
[20] Schaefer EJ,McNamara JR,Shah PK,et a1.Elevated remnant.1ike particle cholester01 and tri-glyceride levels in diabetic men and women in the Framingham Offspring Study.Diabetes Care,2002;25:989-994
[21] Guerin M,Le Goff W. Lassel TS,et a1.Proatherogenic role of elevated cholesteryl ester transfer from HDL to VLDLl and dense LDL in type 2 diabetes:impact of the degree of triglyceri-demia.Arterioscler Thromb Vasc Biol,2001;21:282-288
[22] Kugiyama K,Doi H,Takazoe K,et a1.Rem-nant lipoprotein levels in tasting serum predict cor-onary events in patients with coronary artery dis-ease.Circulation,1999:99:2858-2860
[23] Fukushima H,Kugiyama K,Sugiyama S,et a1.Companson of remnant-like lipoprotem particles ln postmenopausal women with and without coronarv artery disease and in men with coronary artery dis-ease.Am J Cardiol,2001;88:1370.1373
[24] Claudia I,Beatriz L R,John S G,et a1.Are Remnant-Like Particles Independent Predi ctors of Coronary’Hcart Disease Incidence?The Honolulu HeartStudy. Arterioscler Thromb Vasc Biol,2005;25(8):1718—1722
[25] Oi K,Shimokawa J,Hiroki J,et a1.Remnant Lipoproteins from Patients with Sudden Cardiac Death Enhance Coronary Vasospastic Activity Through Upregulation of Rho-Kinase.Arterioscler Thromb Vasc Biol,2004;24(5):918-922
[26] Shin HK,Kim YK,Kim KY,et a1.Remnant Lipoprotein Particles Induce Apoptosis in Endothe-lial Cells bv NAD(P)H Oxidase—Mediated Pro.duction ot 5uperoxide and Cvtokines via LIectin-Like Oxidized Low Density Lipoprotein Receptor-1 Activation:Prevention by Cilostaz01.C irculation,2004:109:1022-1028
[27] Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of anovel, adipose2specific p rotein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol, 2000, 20: 159521599.
[28] Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadi-ponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol, 2003, 23: 85289.
[29] Gensini GG. A more meaningful scoring system for determining the everity of coronary heart disease. Am J Cardiol, 1983, 51: 606.
[30] Kurth T, Gaziano JM, Berger K, et al. Bodymass index and the risk ofstroke in men. Arch InternMed, 2002, 162: 2557-2562.
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