高等真菌Sarcodon joedes子实体化学成分的研究
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摘要
高等真菌Sarcodon joedes为担子菌纲真菌,主要分布于我国云南省。近年来国内外学者从Sarcodon属高等真菌中发现了许多结构新颖、生物活性多样的次生代谢产物,,但Sarcodon joedes的化学成分和生物活性的研究尚未见报道。
本文以采自云南昆明的高等真菌Sarcodon joedes的子实体为研究对象,利用正向硅胶柱层析、Sephadex LH-20凝胶柱层析、RP-18柱层析、薄层制备等方法,从Sarcodon joedes子实体甲醇提取物中分离得到9个单体化合物。经氢谱(1H-NMR)、碳谱(13C-NMR)、质谱(EI-MS, ESI-MS)等波谱技术鉴定了其中的8个化合物,它们的结构分别为:ergosta-7,22-dien-3β-ol(1),麦角甾醇过氧化物(2),3β,5α-dihydroxy-6β-methoxyergosta-7,22- diene(3),(22E,24R)-3β-hydroxy-24-methylcholesta-5,22-dien-7-one(4),苯甲酸(5),对羟基苯甲酸甲酯(6),3,4-二羟基苯甲酸(7),(2S,3R,4E,8E)-1-β-D-glucopyranosyl-3-hydroxy-2-[(R)-2'-hydroxyhexadecanoyl]amino-9-methyl-4,8-octadecadiene(9)。所有化合物均为首次从Sarcodon joedes中分离得到。
Sarcodon joedes, a higher fungus belonging to the class Basidiomycete, is mainly distributed in Yunnan Province of China. In recent years, great attention has been paid to the genus Sarcodon, and many secondary metabolites with new structures and biological activities have been discovered at home and abroad. However, there is no report on the chemical constituents and biological activities of Sarcodon joedes.
In this thesis, the chemical constituents from the fruiting body of Sarcodon joedes were studied, and the research progress in chemical constituents and biological activity of higer fungi was overviewed.
The MeOH extract from Sarcodon joedes was subjected to repeated chromatographic columns such as silica gel, Sephadex LH-20, RP-18 column chromatography and preparative TLC to afford 9 compounds, on the basis of spectroscopic analysis including 1H-NMR, 13C-NMR, EI-MS and ESI-MS, the structures of 8 compounds were elucidated as ergosta-7,22-dien-3β-ol ( 1), ergosterol peroxide (2), 3β,5α-dihydroxy-6β-methoxyergosta-7, 22-diene (3), (22E,24R)-3β-hydroxy-24-methylcholesta-5,22-dien-7-one (4), benzoic acid (5), methyl p-hydroxybenzoate (6), 3,4-dihydroxybenzoic acid (7), (2S,3R,4E,8E)-1-β-D-gluco- pyranosyl-3-hydroxy-2-[(R)-2'-hydroxyhexadecanoyl]amino-9-methyl-4,8-octadecadiene (9), respectively. All of the compounds were isolated from Sarcodon joedes for the first time.
本文以采自云南昆明的高等真菌Sarcodon joedes的子实体为研究对象,利用正向硅胶柱层析、Sephadex LH-20凝胶柱层析、RP-18柱层析、薄层制备等方法,从Sarcodon joedes子实体甲醇提取物中分离得到9个单体化合物。经氢谱(1H-NMR)、碳谱(13C-NMR)、质谱(EI-MS, ESI-MS)等波谱技术鉴定了其中的8个化合物,它们的结构分别为:ergosta-7,22-dien-3β-ol(1),麦角甾醇过氧化物(2),3β,5α-dihydroxy-6β-methoxyergosta-7,22- diene(3),(22E,24R)-3β-hydroxy-24-methylcholesta-5,22-dien-7-one(4),苯甲酸(5),对羟基苯甲酸甲酯(6),3,4-二羟基苯甲酸(7),(2S,3R,4E,8E)-1-β-D-glucopyranosyl-3-hydroxy-2-[(R)-2'-hydroxyhexadecanoyl]amino-9-methyl-4,8-octadecadiene(9)。所有化合物均为首次从Sarcodon joedes中分离得到。
Sarcodon joedes, a higher fungus belonging to the class Basidiomycete, is mainly distributed in Yunnan Province of China. In recent years, great attention has been paid to the genus Sarcodon, and many secondary metabolites with new structures and biological activities have been discovered at home and abroad. However, there is no report on the chemical constituents and biological activities of Sarcodon joedes.
In this thesis, the chemical constituents from the fruiting body of Sarcodon joedes were studied, and the research progress in chemical constituents and biological activity of higer fungi was overviewed.
The MeOH extract from Sarcodon joedes was subjected to repeated chromatographic columns such as silica gel, Sephadex LH-20, RP-18 column chromatography and preparative TLC to afford 9 compounds, on the basis of spectroscopic analysis including 1H-NMR, 13C-NMR, EI-MS and ESI-MS, the structures of 8 compounds were elucidated as ergosta-7,22-dien-3β-ol ( 1), ergosterol peroxide (2), 3β,5α-dihydroxy-6β-methoxyergosta-7, 22-diene (3), (22E,24R)-3β-hydroxy-24-methylcholesta-5,22-dien-7-one (4), benzoic acid (5), methyl p-hydroxybenzoate (6), 3,4-dihydroxybenzoic acid (7), (2S,3R,4E,8E)-1-β-D-gluco- pyranosyl-3-hydroxy-2-[(R)-2'-hydroxyhexadecanoyl]amino-9-methyl-4,8-octadecadiene (9), respectively. All of the compounds were isolated from Sarcodon joedes for the first time.
引文
[1]高锦明.高等真菌代谢产物.西北农林科技大学出版社, 2003,12:1.
[2]中国食用菌网. http://www.mushroom.org.cn/html/articles/machinings/base/20061024328-1.htm [2004-9-30]
[3]刘正南,郑淑芳.中国药用真菌的现状和种质资源.中国食用菌, 1996,15(5):20-21.
[4]兰进,徐锦堂,贺秀霞.我国子囊菌亚门药用真菌资源及利用.中药材, 1996,19(1):11-13.
[5]黄茂先.对我国药用真菌研究发展的浅见.中国食用菌, 1991, 10(2):3.
[6]黄年来.中国食用菌产业的现状和展望.中国食用菌, 1998, 17(5):5.
[7]吴锦文.食用菌的医疗保健作用及其发展趋势.生物学通报, 1999, 34(9):18-19.
[8]杨革.担子菌纲8种真菌的营养成分.无锡轻工大学学报, 2000, 19(2):173-176.
[9] Reiko Watanabe, Masaki Kita, Daisuke Uemura. A novel dipeptide, N-γ-glutamyl boletine, and a cyclic iminium toxin from the mushroom Tylopilus sp. (Boletaceae). Tetrahedron Letters, 2002, 43(37): 6501–6504.
[11]Edwin Biachel, Ulrike Martini, Anke Mayer, Heidrun Anke and Olov Sterner. Omphalotins B, C and D, nematicidal cyclopeptides from Omphalotus olearius. Absolute configuration of omphalotin A, Tetrahedron, 1998, 54(20):5345-5352.
[12]Yoshiaki Amakura, Kazunari Kondo, Hiroshi Akiyama, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, and Tamio Maitani. Conjugated Ketonic Fatty Acids from Pleurocybella porrigens. Chem. Pharm. Bull., 2006, 54(8):1213-1215.
[13]Falk Rasser, Timm Anke and Olov Sterner. Terpenoids from Bovista sp. 96042. Tetrahedron, 2002, 58(39):7785–7789.
[14]Hirotaka Hoshi, Yoko Yagi, Hiroko Iijima, Kenichi Matsunaga, Yoko Ishihara, and Tadashi Yasuhara. Isolation and Characterization of a Novel Immunomodulatoryα-Glucan?Protein Complex from the Mycelium of Tricholoma matsutake in Basidiomycetes. J. Agric. Food Chem., 2005, 53 (23): 8948–8956.
[15]Hirotaka Hoshi, Yoko Yagi, Kenichi Matsunaga, Yoko Ishihara and Tadashi Yasuhara. Development of an Enzyme-Linked Immunosorbent Assay To Detect an Immunomodulatoryα-d-Glucan–Protein Complex, MPG-1, in Basidiomycete Tricholoma matsutake and Related Processed Foods. J. Agric. Food Chem., 2007, 55 (21):8508–8515.
[16]Jiun-Tsai Lin and Wen-Hsiung Liu.ο-Orsellinaldehyde from the Submerged Culture of the Edible Mushroom Grifola frondosa Exhibits Selective Cytotoxic Effect Against Hep 3B Cells Through Apoptosis. J. Agric. Food Chem., 2006, 54 (20):7564–7569.
[17]Hahk-Soo Kang, Eun-Mi Jun, Soon-Hye Park, Soo-Jin Heo, Tae-Soo Lee, Ick-Dong Yoo, and Jong-Pyung Kim, Cyathusals A, B, and C. Antioxidants from the Fermented Mushroom Cyathus stercoreus. J. Nat. Prod., 2007, 70 (6):1043–1045.
[18]Kubo I, Kim M, Wood W F. Clitocine, a new insecticidal nucleoside from the mush room Clitocybe inversa. Tetrahedron Letters, 1986, 27:4277.
[19]Charles L. Cantrell, Bethany P. Case, E. Edward Mena, Toby M. Kniffin, Stephen O. Duke and David E. Wedge. Isolation and Identification of Antifungal Fatty Acids from the Basidiomycete Gomphus floccosus. J. Agric. Food Chem., 2008, 56 (13):5062–5068.
[20]Laura M. Levy, Gabriela M. Cabreraa, Jorge E. Wright, Alicia M. Seldes. 5H-Furan-2-ones fromfungal cultures of Aporpium caryae. Phytochemistry, 2003, 62(22):239–243.
[21]Veronika Hellwig, Johannes Dasenbrock, D?rte Klostermeyer, Stefan Kroi?, Tilman Sindlinger, Peter Spiteller, Bert Steffan and Wolfgang Steglich, New Benzodioxepin Type Strobilurins from Basidiomycetes. Structural Revision and Determination of the Absolute Configuration of Strobilurin D and Relatedβ-Methoxyacrylate Antibiotics. Tetrahedron, 1999, 55(33):10101-10118.
[22]William A. Ayer, Rudong Shan, Latchezar S. Trifonov and Leonard J. Hutchison. Sesquiterpenes from the Nematicidal Fungus Clitocybula oculus. Phytochemistry, 1998,49(2):589-592.
[23]Alberto Arnone, Cristiana De Gregorio, Gianluca Nasini and Orso Vajna de Pava, Isolation and Structure Elucidation of Tsugicolines F-H, Novel Furosesquiterpenes, and Tsugicoline I from the Fungus Laurilia tsugicola. Tetrahedron, 1998, 54(34):10199-10204.
[24]Giovanni Vidari, Zongling Che and Luigi Garlaschelli. New Nardosinane and Aristolane Sesquiterpenes from the Fruiting Bodies of Russula lepida. Tetrahedron Letters, 1998, 39(33):6073 -6076.
[25]Dong-Ze Liu, Fei Wang and Ji-Kai Liu. Sesquiterpenes from Cultures of the Basidiomycete Conocybe siliginea. J. Nat. Prod., 2007, 70(9):1503-1506.
[26]Matías Reina, Juan C. Orihuela, Azucena González-Coloma, Concepción de Inés, Mercedes de la Cruz, Antonio González del Valc, JoséR. Torno, Braulio M. Fraga. Four illudane sesquiterpenes from Coprinopsis episcopalis. Phytochemistry, 2004, 65(4):381–385.
[27]Guo-Hong Li, Meng Duan, Ze-Fen Yu, Lei Li, Jin-Yan Dong, Xing-Biao Wang, Jian-Wei Guo, Rong Huang, Min Wang, Ke-Qin Zhang. Stereumin A–E, sesquiterpenoids from the fungus Stereum sp. CCTCC AF 207024. Phytochemistry, 2008, 69(6):1439-1445.
[28]Fuminori Hiramatsu, Tetsuya Murayama, Takuya Koseki, Yoshihito Shiono. Strobilols A–D: Four cadinane-type sesquiterpenes from the edible mushroom Strobilurus ohshimae. Phytochemistry, 2007, 68(9):1267-1271.
[29]Di Xu, Yu Sheng, Zhong-Yu Zhou, Rong Liu,Ying Leng and Ji-Kai Liu. Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11β-Hydroxysteroid Dehydrogenase Inhibitory Activity. Chem. Pharm. Bull., 2009, 57(4):433-435.
[30]Noemia Kazue Ishikawa, Keiko Yamaji, Satoshi Tahara, Yukiharu Fukushi, Kunihide Takahashi. Highly oxidized cuparene-type sesquiterpenes from a mycelial culture of Flammulina velutipes. Phytochemistry, 2000, 54(8):777-782.
[31]Ying Wang, Michael Dreyfuss, Monique Ponelle, Lukas Oberer, Howard Riezman, A Glycosylphosphatidylinositol-Anchoring Inhibitor with an Unusual Tetracarbocyclic Sesterterpene Skeleton from the Fungus Codinaea simplex, Tetrahedron, 1998, 54(23):6415-6426.
[32]Hiromichi Kenmoku, Takeshi Sassa, and Nobuo Kato. Isolation of erinacine P, a new parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic conversion into erinacines A and B. Tetrahedron Letters, 2000, 41(22):4389-4393.
[33]Carola Valdivia, Melanie Kettering, Heidrun Anke, Eckhard Thines and Olov Sterner. Diterpenoids from Coprinus heptemerus. Tetrahedron, 2005, 61(40):9527-9532.
[34]Zhong-Yu Zhou, Rong Liu, Meng-Yuan Jiang, Ling Zhang, Yun Niu, Ying-Cheng Zhu, Ze-Jun Dong and Ji-Kai Liu. Two New Cleistanthane Diterpenes and a New Isocoumarine from Cultures of the Basidiomycete Albatrellus confluens. Chem. Pharm. Bull., 2009, 57(9):975-978.
[35]Timo H. J. Niedermeyer, Ulrike Lindequist, Renate Mentel, Dirk G?rdes, Enrico Schmidt, Kerstin Thurow, and Michael Lalk. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J. Nat. Prod., 2005, 68(12):1728-1731.
[36]Dang Ngoc Quang, Yuuki Arakawa, Toshihiro Hashimoto, Yoshinori Asakawa. Lanostane triterpenoids from the inedible mushroom Fomitopsis spraguei. Phytochemistry, 2005, 66(14):1656-1661.
[37]E. Dilip de Silva, Sonia A. van der Sar, R. G. Lalith Santha, Ravi L. C. Wijesundera, Anthony L. J. Cole, John W. Blunt, and Murray H. G. Munro. Lanostane Triterpenoids from the Sri Lankan Basidiomycete Ganoderma applanatum. J. Nat. Prod., 2006, 69(8):1245-1248.
[38]Riham Salah El Dine, Ali Mahmoud El Halawany, Norio Nakamura, Chao-Mei Ma, and Masao Hattori. New Lanostane Triterpene Lactones from the Vietnamese Mushroom Ganoderma colossum (FR.) C. F. BAKER. Chem. Pharm. Bull., 2008, 56(5):642-646.
[39]Joachim R?secke, Wilfried A. K?nig. Steroids from the fungus Fomitopsis pinicola. Phytochemistry, 1999, 52(8):1621-1627.
[40]Masao Hirotani, Kou Sai, Seiko Hirotani, Takafumi Yoshikawa. Blazeispirols B, C, E and F, des-A-ergostane-type compounds, from the cultured mycelia of the fungus Agaricus blazei. Phytochemistry, 2002, 59(5):571-577.
[41]F. Wang, J.K. Liu. Two new steryl esters from the basidiomycete Tricholomopsis rutilans. Steroids, 2005, 70(2):127-130.
[42]Henk J. Swarts, Frank J. M. Verhagen, Jim A. Field and Joannes B. P. A. Wijnberg. Trichlororinated phenols from Hypholoma Elongatum. Phytochemistry, 1998, 49(1):203-206.
[43]Sven Silberborth, Anja Stumpf, Gerhard Erkel, Timm Anke, Olov Sterner. Gerronemins A–F, cytotoxic biscatechols from a Gerronema species. Phytochemistry, 2002, 59(6):643-648.
[44]Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Isao Yamamoto, Yuki Hitaka, Masami Tanaka, Yoshinori Asakawa. Thelephantins A, B and C: three benzoyl p-terphenyl derivatives from the inedible mushroom Thelephora aurantiotincta. Phytochemistry, 2003, 62(1):109-113.
[45]Dang Ngoc Quang, Toshihiro Hashimoto, Yuki Hitaka, Masami Tanaka, Makiko Nukada, Isao Yamamoto, Yoshinori Asakawa. Thelephantins D–H: five p-terphenyl derivatives from the inedible mushroom Thelephora aurantiotincta. Phytochemistry, 2003, 63(8):919-924.
[46]Dang Ngoc Quang, Toshihiro Hashimoto, Yuki Hitaka, Masami Tanaka, Makiko Nukada, Isao Yamamoto, Yoshinori Asakawa, Thelephantins I–N: p-terphenyl derivatives from the inedible mushroom Hydnellum caeruleum. Phytochemistry, 2004, 65(8):1179-1184.
[47]Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Isao Yamamoto, Masami Tanaka, Yoshinori Asakawa. Curtisians E–H: four p-terphenyl derivatives from the inedible mushroom Paxillus curtisii. Phytochemistry, 2003, 64(2):649-654.
[48]Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Isao Yamamoto, Masami Tanaka, and Yoshinori Asakawa. Curtisians M - Q: Five Novel p-Terphenyl Derivatives from the Mushroom Paxillus curtisii. Chem. Pharm. Bull., 2003, 51(9):1064-1067.
[49]Niko Radulovic, Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Yoshinori Asakawa. Terrestrins A–G: p-Terphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochemistry, 2005, 66(9):1052-1059.
[50]Huijuan Guo, Hejiao Hu, Shuchun Liu, Xingzhong Liu, Yuguang Zhou and Yongsheng Che. Bioactive p-Terphenyl Derivatives from a Cordyceps-Colonizing Isolate of Gliocladium sp. J. Nat. Prod., 2007, 70(9):1519-1521.
[51]Laura M. Levy, Gabriela M. Cabrera, Jorge E. Wright, Alicia M. Seldes. Indole alkaloids from a culture of the fungus Aporpium caryae. Phytochemistry, 2000, 54(8):941-943.
[52]Alberto Arnone, Adriana Bava, Giovanni Fronza, Gianluca Nasini, and Enzio Ragg. Concavine, an unusual diterpenic alkaloid produced by the fungus Clitocybe concave. Tetrahedron Letters, 2005, 46(46):8037-8039.
[53]Chien-Hui Chen, Gerhard Lang, Maya I. Mitova, Annabel C. Murphy, Anthony L. J. Cole, Laily B. Din, John W. Blunt, and Murray H. G. Munro. Pteratides I?IV, New Cytotoxic Cyclodepsipeptides from the Malaysian Basidiomycete Pterula sp. J. Org. Chem., 2006, 71(21):7947-7951.
[54]Maya I. Mitova, Blair G. Stuart, Grace H. Cao, John W. Blunt, Anthony L. J. Cole, and Murray H. G. Munro. Chrysosporide, a Cyclic Pentapeptide from a New Zealand Sample of the Fungus Sepedonium chrysospermum. J. Nat. Prod., 2006, 69(10):1481-1484.
[55]Alverto Arnone, Gianluca Nasini and Orso Vajna de Pava. A hydroxytetradecatrienoic acid from Mycosphaerella Rubella. Phytochemistry, 1998, 48(3):507-510.
[56]Tatsuya Hasegawa, Mayumi Ishibashi, Takanobu Takata, Fumihide Takano, and Tomihisa Ohta. Cytotoxic Fatty Acid from Pleurocybella porrigens. Chem. Pharm. Bull., 2007, 55(12):1748-1749.
[57]Marlene Svensson, Lennart N. Lundgren, Caroline Woods, Jamshid Fatehi, Jan Stenlid. Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. Phytochemistry, 2001, 56(7):747-751.
[58]Hahk-Soo Kang, Eun-Mi Jun, Soon-Hye Park, Soo-Jin Heo, Tae-Soo Lee, Ick-Dong Yoo, and Jong-Pyung Kim, Cyathusals A, B, and C. Antioxidants from the Fermented Mushroom Cyathus stercoreus. J. Nat. Prod., 2007, 70(6):1043–1045.
[59]Dong-Ze Liu, Fei Wang, Tou-Gen Liao, Jian-Guo Tang, Wolfgang Steglich, Hua-Jie Zhu, and Ji-Kai Liu. Vibralactone: A Lipase Inhibitor with an Unusual Fusedβ-Lactone Produced by Cultures of the Basidiomycete Boreostereum vibrans. Org. Lett., 2006, 8(25):5749-5752.
[60]F.R. Smiderle, L.M. Olsen, E.R. Carbonero, R. Marcon, C.H. Baggio, C.S. Freitas, A.R.S. Santos, G. Torri, P.A.J. Gorin, M. Iacomini. A 3-O-methylated mannogalactan from Pleurotus pulmonarius: Structure and antinociceptive effect. Phytochemistry, 2008, 69(15):2731-2736.
[61]Hisao Shibata, Takashi Tokunaga, Den’ei Karasawa, Akira Hirota, Mitsuru Nakayama, Hiroshi Nozaki and Toshiji Tada. Isolation and Characterization of New Bitter Diterpenoids from the Fungus Sarcodon scabrosus. Agric. Biol. Chem., 1989, 53(12):3373-3375.
[62]Hisao Shibata, Atsushi Irie and Yasufumi Morita. New Antibacterial Diterpenoids from the Sarcodon scabrosus Fungus. Bioscience, Biotechnology, and Biochemistry, 1998, 62(12):2450-2452.
[63]Bing-Ji Ma and Ji-Kai Liu. An Unusual Nitrogenous Terphenyl Derivative from Fruiting Bodies of the Basidiomycete Sarcodon scabrosus. Zeitschrift für Naturforschung. B, 2005, 60(15):565-568.
[64]Mitsuru Hirota, Keiji Morimura, and Hisao Shibata, Anti-inflammatory Compounds from the Bitter Mushroom, Sarcodon scabrosus, Biosci. Biotechnol. Biochem., 2002, 66(1):179-184.
[65]Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, and Yoshiteru Oshima. Scabronine A, a Novel Diterpenoid Having Potent Inductive Activity of the Nerve Growth Factor Synthesis, Isolated From the Mushroom, Sarcodon scabrosus. Tetrahedron Letters, 1998, 39(34):6229-6232.
[66]Takako Kita, Yoshiaki Takaya and Yoshiteru Oshima. Scabronines B, C, D, E and F, Novel Diterpenoids Showing Stimulating Activity. Tetrahedron, 1998, 54(39):11877-11886.
[67]Yutaro Obara, Norimichi Nakahata, Takako Kita, Yoshiaki Takaya, Hironori Kobayashi, Shinzo Hosoi, Fumiyuki Kiuchi, Tomihisa Ohta, Yoshiteru Oshima, Yasushi Ohizumi. Stimulation of Neurotrophic Factor Secretion from 1321N1 Human Astrocytoma Cells by Novel Diterpenoids, Scabronines A and G. European Journal of Pharmacology. 1999, 370(1):79–84.
[68]Bing-Ji Ma, Hua-Jie Zhu, and Ji-Kai Liu. Isolation and Characterization of New Bitter Diterpenoids from the Basidiomycete Sarcodon scabrosus. Helvetica Chimica Acta, 2004, 87(11):2877-2881.
[69]Bing-Ji Ma and Yuan Ruan. Scabronine J, a New Cyathane-type Diterpenoid from the Basidiomycete Sarcodon scabrosus. The journal of Antibiotics, 2008, 61(2):86-88.
[70]Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Curini, M. Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, cyrneines A and B. Planta Medica, 2006, 72(9):819-23.
[71]Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara and Norimichi Nakahata. Cyathane Diterpenes from Sarcodon cyrneus and Evaluation of Their Activities of Neuritegenesis and Nerve Growth Factor Production. Bioorganic & Medicinal Chemistry, 2007, 15(8):2878-2882.
[72]Curini, M., Maltese, F., Marcotullio, M. C., Menghini, L., Pagiotti, R., Rosati, O., Altinier, G., Tubaro, A., Glaucopines A and B, New Cyathane Diterpenes from the Fruiting Bodies of Sarcodon glaucopus. Planta Medica, 2005, 71(2):194-196.
[73]Maria Carla Marcotullio, Rita Pagiotti, Valerio Campagna, Federica Maltese, Giuseppe Fardella, Gianmario Altinier, Aurelia Tubaro. Glaucopine C. A New Diterpene from the Fruiting Bodies of Sarcodon glaucopus. Natural Product Research, 2006, 20(10):917-921.
[74]C. Tringali, M. Piattelli, C. Geraci, G. Nicolosi and C. Rocco. Previously Unreported p-terphenyl Derivatives with Antibiotic Properties from the Fruiting Bodies of Sarcodon leucopus (Basidiomycetes). A Two-dimensional Nuclear Magnetic Resonance Study. Can. J. Chem. 1987, 65:2369-2372.
[75]Valeria Cali, Carmela Spatafora, and Corrado Tringali. Sarcodonins and Sarcoviolins, Bioactive Polyhydroxy-p-terphenyl Pyrazinediol Dioxide Conjugates from Fruiting Bodies of the Basidiomycete Sarcodon leucopus. Eur. J. Org. Chem., 2004, 3:592-599.
[76]Yutaro Obara, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata. A Novel Cyathane Diterpene, Cyrneine A, Induces Neurite Outgrowth in a Rac1-dependent Mechanism in PC12 cells. Life Sciences. 2007, 80(18):1669-1677.
[77]Yutaro Obara, Hironori Kobayashi, Tomihisa Ohta, Yasushi Ohizumi, and Norimichi Nakahata. Scabronine G-Methylester Enhances Secretion of Neurotrophic Factors Mediated by an Activation of Protein Kinase C-ζ. Molecular Pharmacology, 2001, 59(5):1287-1297.
[78]赵丽芳,冯颖,陈晓鸣,惠雅玲,王绍云.翘鳞肉齿菌抑菌试验研究.西南林学院学报, 1998, 18(2): 114-117.
[79]Masashi Mizuno, Yoichi Shiomi, Ken-ichiro Minato, Sachiko Kawakami, Hitoshi Ashida, Hironobu Tsuchida. Fucogalactan Isolated from Sarcodon aspratus Elicits Release of Tumor Necrosis Factor-αand Nitric Oxide from Murine macrophages. Immunopharmacology, 2000, 46(2):113-121.
[80]Toshiyuki Takei, Mitusuru Yoshida, Mayumi Ohnishi-Kameyama, and Masuko Kobori. Ergosterol Peroxide, an Apoptosis-inducing Component Isolated from Sarcodon aspratus (Berk.) S. Ito. Bioscience Biotechnology Biochemistry, 2005, 69(1):212-215.
[81]Tateishi, K, Hosono, T, Shimazu, S, Fujimoto, M. Anti-allergenic Properties of the Fruiting Bodies of Sarcodon aspratus. Journal of the Japanese Society for Food Science and Technology (Japan), 2000, 47(4):281-286.
[82]James F Riordan. Angiotensin-I-converting enzyme and its relatives. Genome Biology, 2003, 4(8): 225-227.
[83]Masaaki Kiyoto, Shingo Saito, Kazuyuki Hattori, Nam-Seok Cho, Takaaki Hara, Yuzo Yagi, Masakazu Aoyama. Inhibitory Effects of L-pipecolic Acid from the Edible Mushroom, Sarcodon aspratus, on Angiotensin I-converting Enzyme. J Wood Sci., 2008, 54(2):179-181.
[84]冯颖,赵丽芳,陈晓鸣,周德群,惠雅玲.翘鳞肉齿菌粗多糖提取和抗肿瘤试验研究.西南林学院学报, 2000, 20(2):117-120.
[85]董玫,王刚,郭文智,孙卓,广田满,丛斌.鳞盖肉齿茵的抗肿瘤细胞增殖活性及抗肿瘤细胞增殖机制的研究.天然产物研究与开发. 2007, 19:88-91.
[86]Anne Caroline Keller, Marc P. Maillard and Kurt Hostettmann. Antimicrobial Steroids from the Fungus Formitopsis Pinicola. Phytochemistry, 1996, 41(4):1041-1046.
[87]高锦明,董泽军,刘吉开.蓝黄红菇的化学成分.云南植物研究. 2000, 22(1):85-89.
[88]Hirokazu Kawagishi, Ruosuke Katsumi, Toshimi Sazawa, Takashi Mizuno, Toshihiko Hagiwara, and Takuji Nakamura. Cytotoxic steroids from the mushroom Agaricus blazei. Phytochemistry, 1988, 27(9): 2777-2779.
[89]G. notaro, V. piccialli, and D.sica. New steroidal hydroxyketones and closely related diols from the marine sponge Cliona copiosa. Journal of natural products, 1992, 55(11), 1588-1594.
[90]杜建厂,王兴娜,谭仁祥,刘吉开.担子菌黄卷缘齿菌的化学成分.中草药,2005, 36(8): 1126-1130.
[91]黄伟欢,薛珺,李药兰,岑颖洲.了哥王芳香类化学成分研究.中草药, 2008, 31(8):1174-1176.
[92]单承莺,叶永浩,姜洪芳,张玖.灯心草化学成分研究.中药材, 2008, 31(3):374-376.
[93]王素娟,裴月湖.白桦叶化学成分的研究.沈阳药科大学学报. 2000, 17(4): 256-257.
[94]Jin-Ming Gao, Lin Hu, Ze-Jun Dong, and Ji-Kai Liu. New glycosphingolipid containing an unusual sphingoid base from the Basidiomycete Polyporus ellisii. Lipids, 2001, 36(5 ).
[2]中国食用菌网. http://www.mushroom.org.cn/html/articles/machinings/base/20061024328-1.htm [2004-9-30]
[3]刘正南,郑淑芳.中国药用真菌的现状和种质资源.中国食用菌, 1996,15(5):20-21.
[4]兰进,徐锦堂,贺秀霞.我国子囊菌亚门药用真菌资源及利用.中药材, 1996,19(1):11-13.
[5]黄茂先.对我国药用真菌研究发展的浅见.中国食用菌, 1991, 10(2):3.
[6]黄年来.中国食用菌产业的现状和展望.中国食用菌, 1998, 17(5):5.
[7]吴锦文.食用菌的医疗保健作用及其发展趋势.生物学通报, 1999, 34(9):18-19.
[8]杨革.担子菌纲8种真菌的营养成分.无锡轻工大学学报, 2000, 19(2):173-176.
[9] Reiko Watanabe, Masaki Kita, Daisuke Uemura. A novel dipeptide, N-γ-glutamyl boletine, and a cyclic iminium toxin from the mushroom Tylopilus sp. (Boletaceae). Tetrahedron Letters, 2002, 43(37): 6501–6504.
[11]Edwin Biachel, Ulrike Martini, Anke Mayer, Heidrun Anke and Olov Sterner. Omphalotins B, C and D, nematicidal cyclopeptides from Omphalotus olearius. Absolute configuration of omphalotin A, Tetrahedron, 1998, 54(20):5345-5352.
[12]Yoshiaki Amakura, Kazunari Kondo, Hiroshi Akiyama, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, and Tamio Maitani. Conjugated Ketonic Fatty Acids from Pleurocybella porrigens. Chem. Pharm. Bull., 2006, 54(8):1213-1215.
[13]Falk Rasser, Timm Anke and Olov Sterner. Terpenoids from Bovista sp. 96042. Tetrahedron, 2002, 58(39):7785–7789.
[14]Hirotaka Hoshi, Yoko Yagi, Hiroko Iijima, Kenichi Matsunaga, Yoko Ishihara, and Tadashi Yasuhara. Isolation and Characterization of a Novel Immunomodulatoryα-Glucan?Protein Complex from the Mycelium of Tricholoma matsutake in Basidiomycetes. J. Agric. Food Chem., 2005, 53 (23): 8948–8956.
[15]Hirotaka Hoshi, Yoko Yagi, Kenichi Matsunaga, Yoko Ishihara and Tadashi Yasuhara. Development of an Enzyme-Linked Immunosorbent Assay To Detect an Immunomodulatoryα-d-Glucan–Protein Complex, MPG-1, in Basidiomycete Tricholoma matsutake and Related Processed Foods. J. Agric. Food Chem., 2007, 55 (21):8508–8515.
[16]Jiun-Tsai Lin and Wen-Hsiung Liu.ο-Orsellinaldehyde from the Submerged Culture of the Edible Mushroom Grifola frondosa Exhibits Selective Cytotoxic Effect Against Hep 3B Cells Through Apoptosis. J. Agric. Food Chem., 2006, 54 (20):7564–7569.
[17]Hahk-Soo Kang, Eun-Mi Jun, Soon-Hye Park, Soo-Jin Heo, Tae-Soo Lee, Ick-Dong Yoo, and Jong-Pyung Kim, Cyathusals A, B, and C. Antioxidants from the Fermented Mushroom Cyathus stercoreus. J. Nat. Prod., 2007, 70 (6):1043–1045.
[18]Kubo I, Kim M, Wood W F. Clitocine, a new insecticidal nucleoside from the mush room Clitocybe inversa. Tetrahedron Letters, 1986, 27:4277.
[19]Charles L. Cantrell, Bethany P. Case, E. Edward Mena, Toby M. Kniffin, Stephen O. Duke and David E. Wedge. Isolation and Identification of Antifungal Fatty Acids from the Basidiomycete Gomphus floccosus. J. Agric. Food Chem., 2008, 56 (13):5062–5068.
[20]Laura M. Levy, Gabriela M. Cabreraa, Jorge E. Wright, Alicia M. Seldes. 5H-Furan-2-ones fromfungal cultures of Aporpium caryae. Phytochemistry, 2003, 62(22):239–243.
[21]Veronika Hellwig, Johannes Dasenbrock, D?rte Klostermeyer, Stefan Kroi?, Tilman Sindlinger, Peter Spiteller, Bert Steffan and Wolfgang Steglich, New Benzodioxepin Type Strobilurins from Basidiomycetes. Structural Revision and Determination of the Absolute Configuration of Strobilurin D and Relatedβ-Methoxyacrylate Antibiotics. Tetrahedron, 1999, 55(33):10101-10118.
[22]William A. Ayer, Rudong Shan, Latchezar S. Trifonov and Leonard J. Hutchison. Sesquiterpenes from the Nematicidal Fungus Clitocybula oculus. Phytochemistry, 1998,49(2):589-592.
[23]Alberto Arnone, Cristiana De Gregorio, Gianluca Nasini and Orso Vajna de Pava, Isolation and Structure Elucidation of Tsugicolines F-H, Novel Furosesquiterpenes, and Tsugicoline I from the Fungus Laurilia tsugicola. Tetrahedron, 1998, 54(34):10199-10204.
[24]Giovanni Vidari, Zongling Che and Luigi Garlaschelli. New Nardosinane and Aristolane Sesquiterpenes from the Fruiting Bodies of Russula lepida. Tetrahedron Letters, 1998, 39(33):6073 -6076.
[25]Dong-Ze Liu, Fei Wang and Ji-Kai Liu. Sesquiterpenes from Cultures of the Basidiomycete Conocybe siliginea. J. Nat. Prod., 2007, 70(9):1503-1506.
[26]Matías Reina, Juan C. Orihuela, Azucena González-Coloma, Concepción de Inés, Mercedes de la Cruz, Antonio González del Valc, JoséR. Torno, Braulio M. Fraga. Four illudane sesquiterpenes from Coprinopsis episcopalis. Phytochemistry, 2004, 65(4):381–385.
[27]Guo-Hong Li, Meng Duan, Ze-Fen Yu, Lei Li, Jin-Yan Dong, Xing-Biao Wang, Jian-Wei Guo, Rong Huang, Min Wang, Ke-Qin Zhang. Stereumin A–E, sesquiterpenoids from the fungus Stereum sp. CCTCC AF 207024. Phytochemistry, 2008, 69(6):1439-1445.
[28]Fuminori Hiramatsu, Tetsuya Murayama, Takuya Koseki, Yoshihito Shiono. Strobilols A–D: Four cadinane-type sesquiterpenes from the edible mushroom Strobilurus ohshimae. Phytochemistry, 2007, 68(9):1267-1271.
[29]Di Xu, Yu Sheng, Zhong-Yu Zhou, Rong Liu,Ying Leng and Ji-Kai Liu. Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11β-Hydroxysteroid Dehydrogenase Inhibitory Activity. Chem. Pharm. Bull., 2009, 57(4):433-435.
[30]Noemia Kazue Ishikawa, Keiko Yamaji, Satoshi Tahara, Yukiharu Fukushi, Kunihide Takahashi. Highly oxidized cuparene-type sesquiterpenes from a mycelial culture of Flammulina velutipes. Phytochemistry, 2000, 54(8):777-782.
[31]Ying Wang, Michael Dreyfuss, Monique Ponelle, Lukas Oberer, Howard Riezman, A Glycosylphosphatidylinositol-Anchoring Inhibitor with an Unusual Tetracarbocyclic Sesterterpene Skeleton from the Fungus Codinaea simplex, Tetrahedron, 1998, 54(23):6415-6426.
[32]Hiromichi Kenmoku, Takeshi Sassa, and Nobuo Kato. Isolation of erinacine P, a new parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic conversion into erinacines A and B. Tetrahedron Letters, 2000, 41(22):4389-4393.
[33]Carola Valdivia, Melanie Kettering, Heidrun Anke, Eckhard Thines and Olov Sterner. Diterpenoids from Coprinus heptemerus. Tetrahedron, 2005, 61(40):9527-9532.
[34]Zhong-Yu Zhou, Rong Liu, Meng-Yuan Jiang, Ling Zhang, Yun Niu, Ying-Cheng Zhu, Ze-Jun Dong and Ji-Kai Liu. Two New Cleistanthane Diterpenes and a New Isocoumarine from Cultures of the Basidiomycete Albatrellus confluens. Chem. Pharm. Bull., 2009, 57(9):975-978.
[35]Timo H. J. Niedermeyer, Ulrike Lindequist, Renate Mentel, Dirk G?rdes, Enrico Schmidt, Kerstin Thurow, and Michael Lalk. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J. Nat. Prod., 2005, 68(12):1728-1731.
[36]Dang Ngoc Quang, Yuuki Arakawa, Toshihiro Hashimoto, Yoshinori Asakawa. Lanostane triterpenoids from the inedible mushroom Fomitopsis spraguei. Phytochemistry, 2005, 66(14):1656-1661.
[37]E. Dilip de Silva, Sonia A. van der Sar, R. G. Lalith Santha, Ravi L. C. Wijesundera, Anthony L. J. Cole, John W. Blunt, and Murray H. G. Munro. Lanostane Triterpenoids from the Sri Lankan Basidiomycete Ganoderma applanatum. J. Nat. Prod., 2006, 69(8):1245-1248.
[38]Riham Salah El Dine, Ali Mahmoud El Halawany, Norio Nakamura, Chao-Mei Ma, and Masao Hattori. New Lanostane Triterpene Lactones from the Vietnamese Mushroom Ganoderma colossum (FR.) C. F. BAKER. Chem. Pharm. Bull., 2008, 56(5):642-646.
[39]Joachim R?secke, Wilfried A. K?nig. Steroids from the fungus Fomitopsis pinicola. Phytochemistry, 1999, 52(8):1621-1627.
[40]Masao Hirotani, Kou Sai, Seiko Hirotani, Takafumi Yoshikawa. Blazeispirols B, C, E and F, des-A-ergostane-type compounds, from the cultured mycelia of the fungus Agaricus blazei. Phytochemistry, 2002, 59(5):571-577.
[41]F. Wang, J.K. Liu. Two new steryl esters from the basidiomycete Tricholomopsis rutilans. Steroids, 2005, 70(2):127-130.
[42]Henk J. Swarts, Frank J. M. Verhagen, Jim A. Field and Joannes B. P. A. Wijnberg. Trichlororinated phenols from Hypholoma Elongatum. Phytochemistry, 1998, 49(1):203-206.
[43]Sven Silberborth, Anja Stumpf, Gerhard Erkel, Timm Anke, Olov Sterner. Gerronemins A–F, cytotoxic biscatechols from a Gerronema species. Phytochemistry, 2002, 59(6):643-648.
[44]Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Isao Yamamoto, Yuki Hitaka, Masami Tanaka, Yoshinori Asakawa. Thelephantins A, B and C: three benzoyl p-terphenyl derivatives from the inedible mushroom Thelephora aurantiotincta. Phytochemistry, 2003, 62(1):109-113.
[45]Dang Ngoc Quang, Toshihiro Hashimoto, Yuki Hitaka, Masami Tanaka, Makiko Nukada, Isao Yamamoto, Yoshinori Asakawa. Thelephantins D–H: five p-terphenyl derivatives from the inedible mushroom Thelephora aurantiotincta. Phytochemistry, 2003, 63(8):919-924.
[46]Dang Ngoc Quang, Toshihiro Hashimoto, Yuki Hitaka, Masami Tanaka, Makiko Nukada, Isao Yamamoto, Yoshinori Asakawa, Thelephantins I–N: p-terphenyl derivatives from the inedible mushroom Hydnellum caeruleum. Phytochemistry, 2004, 65(8):1179-1184.
[47]Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Isao Yamamoto, Masami Tanaka, Yoshinori Asakawa. Curtisians E–H: four p-terphenyl derivatives from the inedible mushroom Paxillus curtisii. Phytochemistry, 2003, 64(2):649-654.
[48]Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Isao Yamamoto, Masami Tanaka, and Yoshinori Asakawa. Curtisians M - Q: Five Novel p-Terphenyl Derivatives from the Mushroom Paxillus curtisii. Chem. Pharm. Bull., 2003, 51(9):1064-1067.
[49]Niko Radulovic, Dang Ngoc Quang, Toshihiro Hashimoto, Makiko Nukada, Yoshinori Asakawa. Terrestrins A–G: p-Terphenyl derivatives from the inedible mushroom Thelephora terrestris. Phytochemistry, 2005, 66(9):1052-1059.
[50]Huijuan Guo, Hejiao Hu, Shuchun Liu, Xingzhong Liu, Yuguang Zhou and Yongsheng Che. Bioactive p-Terphenyl Derivatives from a Cordyceps-Colonizing Isolate of Gliocladium sp. J. Nat. Prod., 2007, 70(9):1519-1521.
[51]Laura M. Levy, Gabriela M. Cabrera, Jorge E. Wright, Alicia M. Seldes. Indole alkaloids from a culture of the fungus Aporpium caryae. Phytochemistry, 2000, 54(8):941-943.
[52]Alberto Arnone, Adriana Bava, Giovanni Fronza, Gianluca Nasini, and Enzio Ragg. Concavine, an unusual diterpenic alkaloid produced by the fungus Clitocybe concave. Tetrahedron Letters, 2005, 46(46):8037-8039.
[53]Chien-Hui Chen, Gerhard Lang, Maya I. Mitova, Annabel C. Murphy, Anthony L. J. Cole, Laily B. Din, John W. Blunt, and Murray H. G. Munro. Pteratides I?IV, New Cytotoxic Cyclodepsipeptides from the Malaysian Basidiomycete Pterula sp. J. Org. Chem., 2006, 71(21):7947-7951.
[54]Maya I. Mitova, Blair G. Stuart, Grace H. Cao, John W. Blunt, Anthony L. J. Cole, and Murray H. G. Munro. Chrysosporide, a Cyclic Pentapeptide from a New Zealand Sample of the Fungus Sepedonium chrysospermum. J. Nat. Prod., 2006, 69(10):1481-1484.
[55]Alverto Arnone, Gianluca Nasini and Orso Vajna de Pava. A hydroxytetradecatrienoic acid from Mycosphaerella Rubella. Phytochemistry, 1998, 48(3):507-510.
[56]Tatsuya Hasegawa, Mayumi Ishibashi, Takanobu Takata, Fumihide Takano, and Tomihisa Ohta. Cytotoxic Fatty Acid from Pleurocybella porrigens. Chem. Pharm. Bull., 2007, 55(12):1748-1749.
[57]Marlene Svensson, Lennart N. Lundgren, Caroline Woods, Jamshid Fatehi, Jan Stenlid. Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. Phytochemistry, 2001, 56(7):747-751.
[58]Hahk-Soo Kang, Eun-Mi Jun, Soon-Hye Park, Soo-Jin Heo, Tae-Soo Lee, Ick-Dong Yoo, and Jong-Pyung Kim, Cyathusals A, B, and C. Antioxidants from the Fermented Mushroom Cyathus stercoreus. J. Nat. Prod., 2007, 70(6):1043–1045.
[59]Dong-Ze Liu, Fei Wang, Tou-Gen Liao, Jian-Guo Tang, Wolfgang Steglich, Hua-Jie Zhu, and Ji-Kai Liu. Vibralactone: A Lipase Inhibitor with an Unusual Fusedβ-Lactone Produced by Cultures of the Basidiomycete Boreostereum vibrans. Org. Lett., 2006, 8(25):5749-5752.
[60]F.R. Smiderle, L.M. Olsen, E.R. Carbonero, R. Marcon, C.H. Baggio, C.S. Freitas, A.R.S. Santos, G. Torri, P.A.J. Gorin, M. Iacomini. A 3-O-methylated mannogalactan from Pleurotus pulmonarius: Structure and antinociceptive effect. Phytochemistry, 2008, 69(15):2731-2736.
[61]Hisao Shibata, Takashi Tokunaga, Den’ei Karasawa, Akira Hirota, Mitsuru Nakayama, Hiroshi Nozaki and Toshiji Tada. Isolation and Characterization of New Bitter Diterpenoids from the Fungus Sarcodon scabrosus. Agric. Biol. Chem., 1989, 53(12):3373-3375.
[62]Hisao Shibata, Atsushi Irie and Yasufumi Morita. New Antibacterial Diterpenoids from the Sarcodon scabrosus Fungus. Bioscience, Biotechnology, and Biochemistry, 1998, 62(12):2450-2452.
[63]Bing-Ji Ma and Ji-Kai Liu. An Unusual Nitrogenous Terphenyl Derivative from Fruiting Bodies of the Basidiomycete Sarcodon scabrosus. Zeitschrift für Naturforschung. B, 2005, 60(15):565-568.
[64]Mitsuru Hirota, Keiji Morimura, and Hisao Shibata, Anti-inflammatory Compounds from the Bitter Mushroom, Sarcodon scabrosus, Biosci. Biotechnol. Biochem., 2002, 66(1):179-184.
[65]Tomihisa Ohta, Takako Kita, Norihiro Kobayashi, Yutaro Obara, Norimichi Nakahata, Yasushi Ohizumi, Yoshiaki Takaya, and Yoshiteru Oshima. Scabronine A, a Novel Diterpenoid Having Potent Inductive Activity of the Nerve Growth Factor Synthesis, Isolated From the Mushroom, Sarcodon scabrosus. Tetrahedron Letters, 1998, 39(34):6229-6232.
[66]Takako Kita, Yoshiaki Takaya and Yoshiteru Oshima. Scabronines B, C, D, E and F, Novel Diterpenoids Showing Stimulating Activity. Tetrahedron, 1998, 54(39):11877-11886.
[67]Yutaro Obara, Norimichi Nakahata, Takako Kita, Yoshiaki Takaya, Hironori Kobayashi, Shinzo Hosoi, Fumiyuki Kiuchi, Tomihisa Ohta, Yoshiteru Oshima, Yasushi Ohizumi. Stimulation of Neurotrophic Factor Secretion from 1321N1 Human Astrocytoma Cells by Novel Diterpenoids, Scabronines A and G. European Journal of Pharmacology. 1999, 370(1):79–84.
[68]Bing-Ji Ma, Hua-Jie Zhu, and Ji-Kai Liu. Isolation and Characterization of New Bitter Diterpenoids from the Basidiomycete Sarcodon scabrosus. Helvetica Chimica Acta, 2004, 87(11):2877-2881.
[69]Bing-Ji Ma and Yuan Ruan. Scabronine J, a New Cyathane-type Diterpenoid from the Basidiomycete Sarcodon scabrosus. The journal of Antibiotics, 2008, 61(2):86-88.
[70]Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata, Curini, M. Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, cyrneines A and B. Planta Medica, 2006, 72(9):819-23.
[71]Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara and Norimichi Nakahata. Cyathane Diterpenes from Sarcodon cyrneus and Evaluation of Their Activities of Neuritegenesis and Nerve Growth Factor Production. Bioorganic & Medicinal Chemistry, 2007, 15(8):2878-2882.
[72]Curini, M., Maltese, F., Marcotullio, M. C., Menghini, L., Pagiotti, R., Rosati, O., Altinier, G., Tubaro, A., Glaucopines A and B, New Cyathane Diterpenes from the Fruiting Bodies of Sarcodon glaucopus. Planta Medica, 2005, 71(2):194-196.
[73]Maria Carla Marcotullio, Rita Pagiotti, Valerio Campagna, Federica Maltese, Giuseppe Fardella, Gianmario Altinier, Aurelia Tubaro. Glaucopine C. A New Diterpene from the Fruiting Bodies of Sarcodon glaucopus. Natural Product Research, 2006, 20(10):917-921.
[74]C. Tringali, M. Piattelli, C. Geraci, G. Nicolosi and C. Rocco. Previously Unreported p-terphenyl Derivatives with Antibiotic Properties from the Fruiting Bodies of Sarcodon leucopus (Basidiomycetes). A Two-dimensional Nuclear Magnetic Resonance Study. Can. J. Chem. 1987, 65:2369-2372.
[75]Valeria Cali, Carmela Spatafora, and Corrado Tringali. Sarcodonins and Sarcoviolins, Bioactive Polyhydroxy-p-terphenyl Pyrazinediol Dioxide Conjugates from Fruiting Bodies of the Basidiomycete Sarcodon leucopus. Eur. J. Org. Chem., 2004, 3:592-599.
[76]Yutaro Obara, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti, Norimichi Nakahata. A Novel Cyathane Diterpene, Cyrneine A, Induces Neurite Outgrowth in a Rac1-dependent Mechanism in PC12 cells. Life Sciences. 2007, 80(18):1669-1677.
[77]Yutaro Obara, Hironori Kobayashi, Tomihisa Ohta, Yasushi Ohizumi, and Norimichi Nakahata. Scabronine G-Methylester Enhances Secretion of Neurotrophic Factors Mediated by an Activation of Protein Kinase C-ζ. Molecular Pharmacology, 2001, 59(5):1287-1297.
[78]赵丽芳,冯颖,陈晓鸣,惠雅玲,王绍云.翘鳞肉齿菌抑菌试验研究.西南林学院学报, 1998, 18(2): 114-117.
[79]Masashi Mizuno, Yoichi Shiomi, Ken-ichiro Minato, Sachiko Kawakami, Hitoshi Ashida, Hironobu Tsuchida. Fucogalactan Isolated from Sarcodon aspratus Elicits Release of Tumor Necrosis Factor-αand Nitric Oxide from Murine macrophages. Immunopharmacology, 2000, 46(2):113-121.
[80]Toshiyuki Takei, Mitusuru Yoshida, Mayumi Ohnishi-Kameyama, and Masuko Kobori. Ergosterol Peroxide, an Apoptosis-inducing Component Isolated from Sarcodon aspratus (Berk.) S. Ito. Bioscience Biotechnology Biochemistry, 2005, 69(1):212-215.
[81]Tateishi, K, Hosono, T, Shimazu, S, Fujimoto, M. Anti-allergenic Properties of the Fruiting Bodies of Sarcodon aspratus. Journal of the Japanese Society for Food Science and Technology (Japan), 2000, 47(4):281-286.
[82]James F Riordan. Angiotensin-I-converting enzyme and its relatives. Genome Biology, 2003, 4(8): 225-227.
[83]Masaaki Kiyoto, Shingo Saito, Kazuyuki Hattori, Nam-Seok Cho, Takaaki Hara, Yuzo Yagi, Masakazu Aoyama. Inhibitory Effects of L-pipecolic Acid from the Edible Mushroom, Sarcodon aspratus, on Angiotensin I-converting Enzyme. J Wood Sci., 2008, 54(2):179-181.
[84]冯颖,赵丽芳,陈晓鸣,周德群,惠雅玲.翘鳞肉齿菌粗多糖提取和抗肿瘤试验研究.西南林学院学报, 2000, 20(2):117-120.
[85]董玫,王刚,郭文智,孙卓,广田满,丛斌.鳞盖肉齿茵的抗肿瘤细胞增殖活性及抗肿瘤细胞增殖机制的研究.天然产物研究与开发. 2007, 19:88-91.
[86]Anne Caroline Keller, Marc P. Maillard and Kurt Hostettmann. Antimicrobial Steroids from the Fungus Formitopsis Pinicola. Phytochemistry, 1996, 41(4):1041-1046.
[87]高锦明,董泽军,刘吉开.蓝黄红菇的化学成分.云南植物研究. 2000, 22(1):85-89.
[88]Hirokazu Kawagishi, Ruosuke Katsumi, Toshimi Sazawa, Takashi Mizuno, Toshihiko Hagiwara, and Takuji Nakamura. Cytotoxic steroids from the mushroom Agaricus blazei. Phytochemistry, 1988, 27(9): 2777-2779.
[89]G. notaro, V. piccialli, and D.sica. New steroidal hydroxyketones and closely related diols from the marine sponge Cliona copiosa. Journal of natural products, 1992, 55(11), 1588-1594.
[90]杜建厂,王兴娜,谭仁祥,刘吉开.担子菌黄卷缘齿菌的化学成分.中草药,2005, 36(8): 1126-1130.
[91]黄伟欢,薛珺,李药兰,岑颖洲.了哥王芳香类化学成分研究.中草药, 2008, 31(8):1174-1176.
[92]单承莺,叶永浩,姜洪芳,张玖.灯心草化学成分研究.中药材, 2008, 31(3):374-376.
[93]王素娟,裴月湖.白桦叶化学成分的研究.沈阳药科大学学报. 2000, 17(4): 256-257.
[94]Jin-Ming Gao, Lin Hu, Ze-Jun Dong, and Ji-Kai Liu. New glycosphingolipid containing an unusual sphingoid base from the Basidiomycete Polyporus ellisii. Lipids, 2001, 36(5 ).