针刺对急性脑梗死患者分泌相蛋白血清超敏C反应蛋白水平影响的临床研究
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摘要
目的:利用现代科学手段来探讨针刺对急性缺血性脑卒中的客观量度,评估病情变化,探讨其病理机制。
     方法:本课题通过对60例急性缺血性脑卒中患者进行随机分组,观察各组病例治疗前后超敏C反应蛋白水平的变化,治疗组为针刺加药物组,本组常规药物治疗第3天开始加入针刺治疗,治疗周期为12天;对照组为药物组,对照组常规药物治疗14天。在入院后1天、14天清晨抽取空腹静脉血3ml进行血清超敏C-反应蛋白含量的检测,系统客观地评价针刺疗法对急性脑梗死的临床疗效。
     结果:治疗组组内比较1d与14d有统计学意义(P<0.05)。对照组组内比较1d与14d有统计学意义(P<0.05)。治疗组与对照组组间比较1d无统计学意义(P>0.05),14d有统计学意义(P<0.05)。
     结论:1、于氏头针能降低急性缺血性脑梗死患者血清超敏C-反应蛋白水平,并有良好临床疗效;2、于氏头针加常规药物治疗疗效优于单纯常规药物治疗,有统计学意义。
[Object]:The purpose is to explore acupuncture on acute ischemic stroke with the measure of modern science, evaluate the changes of illness.
     [Methods]:Through this project,60 patients with acute ischemic stroke were randomly assigned to observe the changes of the high sensitive C-reactive protein, the treatment group is acupuncture and medication group, the acupuncture treatment started at the third day of conventional drugs treatment for the treatment group, the control group is medication group, the treatment cycle is 12 days; the conventional drugs treatment for the control group last for 14 days. The 1st and the 14th after admission, high sensitive C-reactive protein test of fasting venous blood for 3ml serum, the system objective assessment of acupuncture on acute cerebral infarction.
     [Results]:The compare in the treatment group of lst and 14th is significant in statistics (P<0.05). The compare between the control group and treatment group of 1st and 14th is significant in statistics(P<0.05). The compare between the treatment group and the control group of 1st is no significant in statistics, and 14th is significant in statistics (P<0.05).
     [Conclusion]:1.Yu's scalp acupuncture can reduce the high sensitive C-reactive protein of the acute ischemic stroke patients, and the effect of the treatment is prominent; 2.Therapy both the Yu's scalp acupuncture and conventional drugs treatment is better than conventional drugs treatment alone, and is significant in statistics.
引文
[1]Pepys MB, Berger A et al. The renaissance of C reactive protein. British Medical Journal,2001,322:4-5
    [2]王志静,吴敬,任铁生等.脑卒中临床流行病学分析.中华流行病学杂志2003:24(1):73-74
    [3]Eikelboom JW, Hankey GJ, Baker RI, et al. C-reactive protein in ischemic stroke and its etiologic subtypes [J]. Stroke Cerebrovasc Dis, 2003,12(2):74-81.
    [4]金惠铭.病理生理学[M].北京:人民卫生出版社,2001.
    [5]Tohgi H, Takahashi H. Ischemic stroke among in patients with preceding in flammatory response [J].Thromb Res,2001,104 (5):375-377.
    [6]Arenillas JF, Alvarez-Sabin J,Molina CA,et al.C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. Stroke,2003, 34:2463-2468
    [7]Di Napoli M, Papa F, Bocola V, et al. Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke. Stroke,2001, 32:133-138
    [8]Di Napoli M, Schwaninger M, Cappelli R,et al. Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP pooling project members. Stroke,2005,36:1316-1329
    [9]高建国,周农,翟金霞。血清C反应蛋自水平与脑梗死预后的关系[J].临床神经病学杂志,2005,258(2):145-152.
    [10]Hamidon BB, Sapiah S,Nawavi H,et al.The prognostic value of C-reactive protein(CRP) levels in patients with acute ischaemic stroke[J]. Med J Malaysia,2004,59 (5):631-637.
    [11]包来发主编.李中梓医学全书.中国中医药出版社,2004
    [12]张介宾原著,孙玉信,朱平生主校.景岳全书.第二军医大学出版社,2006
    [13]吴谦等编.医宗金鉴.人民卫生出版社,2002.
    [14]明.楼英编撰.医学纲目.中国中医药出版社,1998
    [15]赵斌.中风病系统概念的中西医学比较之我见.甘肃中医,2006,19(8):45-46
    [16]上海中医学院文献研究所主编..历代中医珍本集成.雪雅堂医案.上海三联书店,1990
    [17]张锡纯.医学衷中参西录.河北科学技术出版社,2002
    [18]田立,唐可清.中风病各期病机变化浅析[J].光明中医,1997, 12(2):2
    [19]邹怀忆.中风病外因致病学说的再认识[J].中国中医基础医学杂志,1997,:3(3):17
    [20]姬晓东,高志刚.姬乾园治疗中风临床经验撷粹.山西中医,1997,13(2):5
    [21]海丽,盛力.益气活血法治疗中风急性期30例临床体会.实用中医内科学,1997,11(1):38
    [22]潘源浩,郑天飞,韦月梅.祛痰化疲复遂汤治疗急性脑梗塞78例[J].广西中医学院学报,2000,17(4):26-27
    [23]鲁启洪,刘红艳,韩忠顾,许先金.缺血性中风的中医药疗法.中医药学刊,2006,24(8):1534-1535
    [24]陶根鱼,杜晓泉.益气活血法在缺血性中风病中的地位[J].陕西中医学院学报,1998,21(2):1-2
    [25]张树泉,李世杰.论补肾活血化寮是脑梗塞的基本治法[J].山东中医杂志,1997,16(12):534
    [26]张国亭,赵青春泻下逐癖汤治疗缺血牲中风急性期36例[J].中国中医急症,2001,40(4):237
    [27]魏和国,刘欣.平逆通络汤口服液治疗急性脑梗塞152例临床观察[J].天津中医,1995,12(4):17-21
    [28]王永炎.关于提高脑血管疾病疗效难点的思考[J].中国中西医结合杂志,1997,17(2):195-196
    [29]李澎涛,王永炎,黄启福.“毒损脑络”病机假说的形成及其理论与实践意义[J].北京中医药大学学报,2001,24(1):1-6
    [30]曹建忠,杨光田,刘书山.葛根素对脑缺血再灌注时海马CA1区细胞凋亡和C-fos蛋白表达的影响[J].中国中西医结合急救杂志,2002,9(4):238-240.
    [31]张海生.大剂量丹参注射液治疗缺血性脑血管病120例[J].陕西中医, 1991,12(4):155
    [32]曲友直,高国栋,赵振伟,等.川芎嗪、黄芪刘脑缺血再灌注后神经细胞凋亡及Fos蛋白表达的影响[J].卒中与神经疾病,2004,11(2):111-112.
    [33]匡忠生,谢宇晖,李翎,等.石菖蒲提取液对脑缺血-再灌注诱导的神经细胞凋亡的保护作用[J].广东医学,2002,23(5):459-460.
    [34]秦兵,张根葆,陈冬云,等.银杏内酯B对脑缺血再灌注神经元损伤的保护作用[J].中国中西医结合急救杂志,2005,12(1):17-20.
    [35]蔡卫斌,杨中汉,李朝阳,等.银杏内酯B对谷氨酸诱导脑皮质神经元凋亡及Ca2+超载的影响[J].中国病理生理杂志,2005,21(4):652-656.
    [36]曹翠丽,马常升,马文领,等.中药水蛭对缺血/再灌注后脑细胞的抗凋亡作用[J].河北医科大学学报,2000,21(4):193-195.
    [37]吴莘,汪坚敏,张春炳,等.葛根素联合丹参对急性脑梗死患者血管内皮功能的影响[J].医师进修杂志(内科版),2004.27(7):19-20.
    [38]王新高,童萼塘,孙圣刚.补阳还五汤对脑缺血再灌注大鼠皮质神经细胞凋亡的影响[J].现代中西医结合杂志,2005,14(3):306-309.
    [39]胡建鹏,王键,李净.益气活血方对脑缺血再灌注损伤神经细胞凋亡及HSP70蛋白表达的影响[J].中国实验方剂学杂志,2005,11(2):72-75.
    [40]李净,王键.脑络欣通对脑缺血再灌注损伤模型鼠神经细胞凋亡及相关基因的影响[J].中国中医基础医学杂志,2003,9(6):33-35.
    [41]罗薇,阎小萍,王吴.通脉益智胶囊对脑缺血再灌注损伤诱导的小鼠海马神经细胞凋亡的影响[J].北京中医药大学学报,2003,26(5):59-62.
    [42]刘泰,韦必清,韦玉进.醒脑通脉胶囊对脑缺血再灌注损伤神经细胞凋亡的影响[J].辽宁中医杂志,2005,32(2):8991.
    [43]傅强,崔华雷,孙中吉,等.酚脑静注射液对脑缺血再灌注诱导的脑神经细胞凋亡防治作用的实验研究[J].中国中西医结合急救杂志,2000,7(3):144-146.
    [44]顾玲.高玉培,王廷华等.血塞通对局灶性脑缺血细胞凋亡及Bax,Bcl一2表达的影响[J].昆明医学院学报.2002, (3):34-36.
    [45]逄涛,逄艳丽.疏血通治疗急性脑梗塞的疗效观察[J],药物与临床,2006,14(5):388.
    [46]王松.疏血通对急性脑梗死患者肿瘤坏死因子和细胞问粘附分子含量的影响[J]. 医药导报2004,23(2):5456.
    [47]姚宏军.舒血宁注射液治疗缺血性中风急性期不同证型的疗效观察[D]山西医科大学,2010
    [48]盛力.通窍活血汤加味治疗脑血栓154例.辽宁中医杂志,2003,30(12):1002
    [49]吴玉生,李士林,张道杰,王占奎.补阳还五汤对早期脑梗塞患者的治疗效果.中西医结合实用临床急救,1996;3(8):343-344.
    [50]黄敏.涤痰活血汤治疗急性脑梗死62例[J].中国中医药信息杂志.2002,11(3):245-246.
    [51]徐寅平化痰活血复原汤治疗急性缺血性中风60例的临床观察[J].2004,23(10):284-286.
    [52]承颖亮中风消积合剂治疗急性缺血性中风41例临床应用体会[J].时珍国医国药,2006,17(12):2576.
    [53]江翠红,丁爱国,天灵再造液治疗急性缺血性中风临床观察[J].中国中医急症,2006,15(9):937.
    [54]李小慧,范恒,石拓,陈克进.刺五加注射液治疗急性缺血性中风50例临床观察[J].湖北中医学院学报,2002,4(6):38.
    [55]郑安,等.华佗再造丸治疗急性脑血管病偏瘫56例临床疗效分析[J].福建中医药,1988,19(2):5.
    [56]陈文,谭敏,梁立安,等.艾灸足三里、悬钟对缺血性风脑血管功能的影响及其临床意义[J].中国针灸,2006,6(3):161-165.
    [57]陈文,顾红卫,马维平,等.针刺足三里、悬钟对缺血中风患者脑血管功的影响多中心随机对照研究[J].中国针灸,2006,26(12):851-553.
    [58]王艳君,袁军,李梅,等.氧针疗法治疗缺血性脑血病的临床研究[J].四川中医2006,24(11):98-99.
    [59]张红星,周利,张唐法.头针治疗脑卒中对相关血生指标的影响[J].中国临床康复,2006,10(19):9-11.
    [60]肖晓华,李瑞春,朱红霞,等.头穴透刺电针治疗缺血性中风临床观察[J].上海针灸杂志.2008,27(6):6-8
    [61]吴文岁,付克英.推拿治疗脑出血偏瘫48例疗效观察[J].中国中医药信息杂志,1997,4(10):46
    [62]周光辉.推拿治疗与易化技术对脑卒中患者运动功能影响的对比研究[J].按摩与导引,2002,18(6):17
    [63]蒋小燕,周淑花,王海清,等.治疗量超声波对青年血浆内皮素和心钠素的影响[J].中国康复,2002,17(1):27-28.
    [64]牛秀茹,邢军.康复训药联合高压氧综合治疗卒中后吞咽障碍[J].中国康复,2008,23(12):417
    [65]江震饮,张国忠.高压氧对脑梗死患者血浆C-反应蛋白含量的影响[J].内科2009,4(2):15-17
    [66]肖岚,黎吉群.白介素-6与脑缺血损伤[J].国外医学:神经病学与神经外科学分册,2000,27(5):259-261
    [67]黄松波,刘凤珍,董爱勤等.旱期主动性康复对脑梗塞偏瘫患者下肢运动功能的影响[J].现代康复,2000,4(6):832-833.
    [68]黄苡苹,黄丽君.早期康复干预对脑卒中患者日常生活活动能力的影响[J].现代康复,2000,4(4):578.
    [69]高丽萍,霍杏暖,张雅静等.旱期康复训练对急性脑梗塞患者功能恢复的影响[J].中华护理杂志,1999,34(7):392-393.
    [70]缪鸿石,朱铺连.脑卒中的康复评定和治疗[M].北京:华夏出版社.1996:162-165.182.
    [71]南登昆.实用物理疗法[M].北京:人民军医出版社,2001:316-318
    [72]东贵荣,张宣,李丹等.针刺治疗急性高血压性脑出血的临床研究[J].中国针灸1994;(3):13
    [73]周君,关亚新,孙中田.电针刺激头穴不同部位对中风偏瘫病人肌力即刻效应的观察.针灸临床杂志[J],2002,18(4):23
    [74]韩舰华.头皮针治疗急性缺血性中风120例疗效观察[J].上海针灸杂志2004;23(8):14
    [75]范春疆,王凤艳.针刺头穴为主治疗中风120例[J].针灸临床杂志,2004,20 (3):9
    [76]靳瑞.颞三针治疗中风后遗症的临床观察[J].中国针灸,1993,13(1):1.
    [77]伦新,彭增福,彭淑珍.颞三针为主治疗中风后遗症的临床观察[J].针灸临床杂志,1999,15(4):8
    [78]郭元琦,陈丽仪,符文彬等.分期整体针灸法治疗脑梗死临床对照研究[J].中国针灸.2005,25(6):395-398
    [79]陈晓军,方针,罗高权等.调和阴阳针刺法治疗急性脑梗死临床观察[J].上海针灸杂志.2009,28(4):211-213.
    [80]钱晓平,徐芳,宋佳霖等.不同针刺频次对脑梗死恢复期患者疗效的影响[J].中国针灸.2009,29(1):7
    [81]管遵惠.舌针的理论及临床运用[J].云南中医学院学报,188,11(4):23.
    [82]李湘力,蔡敬宙,江钢辉.舌三针治疗中风失语症30例[J].针灸临床杂志.2009,25(7):6-9
    [83]彭静山.眼针为主治疗中风167例临床观察[J].中国针灸,1987, (6):23.
    [84]樊莉,吴思平,李滋平等.眼针配合运动针法治疗脑梗死恢复期偏瘫临床观察[J].新中医.2009,41(6):93-94
    [85]车建丽.腹针治疗较长病程中风后遗症40例临床观察[J].江苏中医药,2002,23(1):31.
    [86]王东升,王顺,孔令丽等.腹部电针治疗中风后便秘临床观察[J].中国针灸.2008,28(1):7-9
    [87]苏尔亮.巨刺三步法治疗中风偏瘫120例[J].辽宁中医杂志,1998,25(4):178.
    [88]姜华,王满霞,郭力.子午流注纳甲法治疗急性缺血性脑中风及对血液流变学的影响[J].中国中医药信息杂志,2003,10(5):75-76.
    [89]张勇,张翠平,李志英.穴位注射提高气虚血瘀型中风偏瘫肢体肌力35例[J].中国针灸,2001,21(7):410
    [90]钟志国,李小龙.针刺结合穴位注射治疗中风偏瘫临床观察[J].上海针灸杂志2004,23(6):15-16.
    [91]黄金香.针刺治疗急性脑梗塞临床观察[J].中国全科医学杂志,2008,2(4):299
    [92]纪美玉.头针配合体针治疗缺血性中风86例临床观察[J].中国针灸,1999,增刊:12
    [93]李成永.针刺治疗急性脑梗塞的临床疗效研究[J].针灸临床杂志,2000,16(9):7-9
    [94]金从华.头针配合皮肤针治疗中风68例[J].上海针灸杂志,2001,20(4):3
    [95]陈有国.头针为主治疗急性脑梗塞近期疗效对比观察[J].中国针灸,2001, 21(10):589-590
    [96]俞吕德,吴炳煌,洪安辉等.头针加药物治疗早期脑梗塞患者的疗效观察[J].中国针灸,2003,23(2):67-69
    [97]孟庆刚,高兵兵,孔庆爱,等。头穴透刺配合溶栓治疗急性脑梗塞的监床机理研究。中国针灸,2001,21(4):243-246
    [98]Jenkins PO, TurnerMR, Jenkins PF. What is the p lace of thr ombolys is in acute stroke? A review of the literature and a current pers pective[J]. Clin Med,2008,8(3):238-253
    [99]De Graba TJ The role of inflammation after acute stroke:utility of pursuing anti-adhesion molecule theraphy [J]. Neurology.1998,51 (3 supply): s62-68
    [100]DimaglU, Iadecola C, Moskowitz MA.Pathobiology of ischacemic stroke: an intergrated view[J]. Trends Neurosci,1999,22; 391-397
    [101]Di Napoli M, Papa F, Bocola V.C-reactive protein in ischemic stroke: an independent prognostic factor[J]. Stroke,2001,32:917-924
    [102]Canova CR, Courtin C, Reinhart WH. C-reactive protein(CRP) in cerebrovascular events[J].Atherosclerosis,1999,147:49-53
    [103]Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation [J]. Circ Res.2001,89(9):763-771
    [104]Ma TZ, Wan Q. The fluctuation of plasm a inflammation cytokines fibrinolytic activity in patients with acute cerebralinfarctionon and elfeet on nerve function[J]. Zhongguo Linchuang Kangful,2003,7:1875-1878.
    [105]Emsley HC, Smith CJ, Gavin CM, et al. An early and sustained peripheral inflammatory response in acute ischaemic stroke:relationships with infection and atherosclerosis[J]. Neuroimmunol,2003,139:93-101
    [106]Venugopal SK, Devaraj S, Yuhanna I et al. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells[J]. Circulation,2002,17,106(12):1439-1441
    [107]Wolbinkv GJ, Brouwer MC, BuysmannS, et al:CRP mediated activation of complement in vivo:assessment by measuring circulating complement-C-reactive protein complexes[J]. Immunol 1996,157:473-479
    [1O8]Pepys MB, HirschfieldGM: C-reactiveprotein:acritical update[J]. Clin Invest 2003,111:1805-1812
    [109]Ryu SR, Choi IS, Bian RX, Kim JH, et al. The effect of C-react ive protein on functional outcome in ischemic strokepatients[J]. Neurosci,2009,119(3): 336-344
    [110]Montaner J, Fernandez. Caderms I, Molina CA. etal. Postmke C-reactive protein is a powerful prognostic tool among candidates forthrombolysis[J]. Stroke,2006,37(5):1205-1210.
    [111]王爱民,周颖,肖波,等.脑梗死患者血清C反应蛋白水平的变化及其临床意义[J].临床神经病学杂志,2005,18(2):153-154
    [112]Takai Y.Kishimoto A. Inoue M, et al.Studies on acyclic neurotide independent protein kinase and its proenzyme in mammalisan tissue[J].Bio Chem.1997,252 (61):7603
    [113]周伟,缺氧缺血性脑损伤的分子生物学研究进展[J].国外医学儿科学分册1998:25(1):33-35
    [114]Dawso VL,Dawson TM,Batley DA,et al.Mechanism of nitric oxide-mediated neurotoxity in primary brain cultures[J].Neurosic,1993,13(6):2651-2661
    [115]Kontos HA.Oxygen radicals in cerebral ischemia:the 2001 Willis leceture[J].Stroke,2001,32:2712-2716
    [116]Bates B,Hirt L,Thomas SS,et al.Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen glucose deprivat ion,and oxidative stress:possible involvement of oxygen free radicals[J]. Neurobiol Dis,2002,9(1):24-37
    [117]李炜如.兴奋性氨基酸及钙离子内流在缺氧缺血性脑损伤中的作用[J].中国实用儿科杂志,1997;12(4):245--246
    [118]孟强.单胺类神经递质与缺血性脑损伤[J].国外医学脑血管疾病分册1998:6(2):71-73
    [119]Di Napoli M, Papa F, Bocola V. C-reactive protein in ischemic stroke: an independent prognostic factor [J].Stroke,2001,32 (4):917-924.
    [120]Eikelboom JW,Hankey GJ, Baker RI, et a1. C-reactive protein in ischemic stroke and its etiologic subtypes[J].Stroke Cerebrovasc Dis, 2003,12(2):74-81.
    [121]金惠铭.病理生理学[M].北京:人民卫生出版社,2001.
    [122]Tohgi H, Takahashi H.Ischemic stroke among in patients with preceding in flammatory response[J].Thromb Res,2001,104 (5):375一:377.
    [123]Calabro P. will erson JT, Yeh ET. Inflamatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cell s[J].Citculat-ion 2003,108:1930-1932
    [124]张敬伟,魏殿军.超敏C-反应蛋白检测在脑梗死诊断中的应用[J].天津医科大学学报,2006,12(2):311.
    [125]王国庆,康爱英.超敏C反应蛋白和白细胞介素6与缺血性脑卒中的关系[J].第四军医大学学报,2005,26(3):137.
    [126]陈应柱,邵国富,吴冠会等.急性脑梗死病人血清超敏C反应蛋白水平变化及其与TOAST分型关系的研究[J].临床神经病学杂志,2006,19(1):15.
    [127]李倩.缺血性脑卒中病人血清hs-CRP和SF水平[J].放射免疫学杂志.2006,19(1):59.
    [128]王爱民,周颖,肖波等.脑梗死患者血清高敏C-反应蛋白水平的变化及其临床意义[J].临床神经病学杂志,2005,18(2):153-154
    [129]Di Napoli M, Papa F, Bocola V. C-reactive protein in ischemic Stro ke:an i-ndependent prognostic fator[J]. Stroke 2001,32:917-924
    [130]BI ann AD, Lip GY. Effects of C-reactive protein on the release of von Willebrand factor, E-selectin, thrombomodulin and intercellular adhesion molecule-1 from human umbilical vein endothelial cells [J]. Blood Coagul Fibrinolysis,2003,14:335-340.
    [131]Ridker PM,Cushman M,stampfer MJ,et al.Plasma-concentration of C-reactive rotein and risk of developing peripheral vascular disease[J]. Circulation, 1998,97(5):425-428
    [132]Pence S, Yilmaz G, Yimaz N,et al.Determination of plasma fibronectin and serum C-reactive protein in patients with cerebrocacular events[J].CIin Prac t,2003,57(2):91一95.
    [133]郭毅,姜昕,陈实,等.C-反应蛋白-缺血性脑卒中预后的重要标志物[J].中华预防医学杂志,2003,37(2):102-104.
    [134]Mu i r Kw, weri CJ, Alwann W, et aI. C-reactive protein and outcome after ischemic stroke [J]. Stroke,1999,30:981-985
    [135]Cermak J, Key NS, Bach RR, etal. C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor[J]. Blood,1993,82:513-520
    [136]Landi G, D'Angelo A, Boccardi E, et al. Hyper-coagulability in acute stroke:prognostic significance[J]. Neurology,1987,37:1167一1671
    [137]Dirnagl U,Iadecola C,Moskowitz MAl.Pathobiology of ischaemic stroke: an integrated view [J]. Trends Neurosci,1999,22:391-397
    [138]Iyigum I, Bakirei Y. Plasma coneetradons of C-reactive protein and fibrinogen in ischaemic stroke[J].Med Res,2002:30:591-596
    [139]Torzewski J,Torzewski M, Bowyer DE, et al. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early at herosclerotic lesions of human coronary arteries[J]. Arterioscler Thromb Vasc Biol,1998,18:1386一1392.
    [140]Montaner J, Fernandez Cadenas I, Molina CA, et al. Post stroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis[J]. Stroke,2006,37:1205.
    [141]Inaba K, Inaba M, Romani N,et al.Generation of Iarge numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulatingfactor[J]. J Exp Med,1992,176(6):1693-1702.
    [142]Rost NS, Wolf PA, Kase CS, et al. Plasma concent ration of C-reactive protein and risk of ischemic stroke and transient ischemic attack:the Framingham study[J].Stroke,2001,32:2575-2579.
    [143]Di Napoli M,Papa F, Bocola V, et aI. C-reactive protein in ishemic stroke:an independent prognostic factor[J]. Stroke,2001,32:917.
    [144]Astrup J, Siesjo symonm L.Thresholdsin cerebral ischemic theischemia penumbra[J].Stroke.1981,12:723.
    [145]包华.尿激酶静脉溶栓治疗脑梗塞研究[J].中国综合临床.2002,18(1):55-56
    [146]李朝晖.超早期rt-PA溶栓治疗脑梗塞的临床研究[J].中国康复理论与实践.2007,13(1):72-73.
    [147]International Stroke Trial Collaborative Group.The international Stroke Trial (IST):arandomized among 19345 patients with acute isehemic stroke[J]. Lancet,1997,349:1569-1581.
    [148]CAST(Chinese Acute Stroke Trial)Collaboration Group.CAST:randomized Placebo-controlled trial of early patients with acute isehemic stroke[J].Lancet,1997,1641-1649.
    [149]Lapchak PA.Development of thrombolytic therapy for stroke:a perspective. Expert Opinion Investig Drugs,2002,11 (11):1623-1632
    [150]Saxena R,Koudstal PJ. Anticogulants for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or ransient ischemic attack [J]. Cochrane Database SystRev.2000,2:CD000185.
    [151]张洪春,石志华,张秀林.观察大剂量巴曲酶对急性脑梗死患者的疗效[J].中国医药导报.2008,5(4):48
    [152]韩丽,刘彦书,马新顺等.巴曲酶注射液治疗进展性脑梗死疗效观察[J].中国实用神经疾病杂志2008,11(1):68
    [153]张立群,陈洁丽,程焱等.尼莫地平对局灶性脑缺血鼠脑血浆蛋白的影响[J].中风与神经疾病杂志,2001:18:300
    [154]Danton GH,Dietrich WD. Inflammatory mechanisms after ischemia and stroke[J]. Neuropathol Exp Neurol,2003.62 (2):127-136
    [155]Jung N, Chopp M, Chawala S. Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat[J]. Brain Res,1998.788 (1-2):25-34
    [156]Hara H, Friedlander RM, GanIiardim V,et al. Inhibition of inerleukin I beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage[J]. Proc Natl Acad Sci USA.1997,94 (5):2007-2012
    [157]Emsley HC, Yynell PJ Inflatmnation and infection in clinical stroke[J].Cereb Blood Flow Metab.2002,22(12):1399-1419
    [158]Watanabe T, Yuki S, Egawa M. Protective effects of MCI-186 on cerebral ischemia:possible involvement of free radical scavenging and antioxidant acions[J]. Phannacol Exp Ther,1994,268(3)1597-1604
    [159]Wu TW, Zeng LH, Wu J, Fung KP. MCI-186:further histochemical and biochemical evidence of neuroprotection[J]. Life Sci,2002,67(19):2387-2392
    [160]陈静宜. 一种改善脑卒中病残性药物-依达拉奉[J].中国临床药学杂志,2002,11(4):244-245
    [161]Alkayed NJ, Goto S, Sugo N, et al. Estrogen and Bcl-2:gene induction and effect of reansgene in experimental stroke[J]. Neurosci,2001,21(9) 7543-7550
    [162]李文,包仕尧.碱性成纤维细胞生长因子治疗脑梗死研究进展[J].国外医学脑血管疾病分册,1997,7(4):227
    [163]Shinn ZL, Holler BJ, KaPlan P, et al. Osteogenic protein-1 Protects against cerebral infarction induced by MCA ligation in adult rats[J]. Stroke,1999:30(1):126-133
    [164]徐仁,黄怀钧,王凤霞等.神经节苷脂对缺血性大鼠脑保护作用的研究[J].中风与神经疾病杂志,1999,16(3):155-156
    [165]Yasmernin G, Bolay H. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischernia[J]. Stroke,2000,31(8):1974-1980
    [166]苏庆杰,黄如训,李玲等.胰岛素对局灶性脑缺血再灌注损伤的作用[J].中医神经病疾病杂志,1999,25(5):283-285
    [167]BelayevL, liuY, etal. Human albumin therapy of acute ischernic stroke marked neuroprotective efficacy at moderate doses and with a broad therapeutic window[J]. Stroke.2001,32(2):553-560
    [168]Bradley J, Hindman, Michael M, et al.Mild hypothermia as a protective therapy during intracranial aneurysm surgery:a randomized prospective pilot trial[J].Neurosurgery,1999,44(1):23-32
    [169]Yang Z J, Camporesi C, Yang X, et al. hyperbar ic oxygenation mitigate(?) focal cerebral injury and reduces striatal dopamine release in a rat model of transident middle cerebral artery occlusion[J].Appl Physiol.2002.87(2): 101-107
    [170]Badr AE, Yin W, Mychaskiw q et al. Effect of hyperbaric oxygen on striatal metabolites:amicrodialysis study in awake freely moving rats after MCA occlusion[J].Brain Res.2011,916 (1-2):85-90
    [171]中华神经科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996;29(6):379-380
    [172]国家中医药管理局脑病急症科研组.中风病诊断与疗效评定标准(试行)[J].北京中医药大学学报,1996,19(1):55-56
    [173]Graham LM Daly LE, Refsum HM, et al. Plasma homocysteine asariskfactor for vascular disease[J].JAMA,1997,277951):1775-1781.
    [174]王泽.于氏头针对脑卒中危险因素血清超敏C-反应蛋白的影响[D].2009
    [175]王富春,于仙玫,邓瑜等.头针疗法[M].第一版.人民卫生出版社,2003:8
    [176]Libby P, Ridker PM. Novel inflammatory markers of coronary risk:theory versus practice[J]. Circulation,1999:100:1148-50.
    [177]Pearson TA,Mensah GA,Alexander RW,et al.Markers of inflammation and cardiovascular disease:application to clinical and public health practice:a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association[J]. Circulation.2003;107:499-511.
    [178]马健浩.C反应蛋白测定在维持血液透析患者中的临床意义[J].中国基层医药,2005,12(11):1154-1155
    [179]Biasucci LM,Liuzzo G,Grillo RL,et al.Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instablity [J]. Cir-culation,1999,99(7):855.
    [180]DiNapoli M, Papa F, Bocola V.C-reactive protein in ischemic stoke:an independent prognostic factor [J].Stroke,2001,32(4):917.
    [181]曹理璞.急性脑血管病患者超敏C反应蛋白测定的临床意义[J].实用临床医 学,2005,6(3):16-17.
    [182]王玉升,电针对急性局灶性脑缺血模型大鼠的影响[J].中国针灸,1996,(9):34
    [183]朱蓓蕾,王贞,叶天中等.醒脑开窍针刺加头针法对急性脑梗死的临床疗效及超敏C反应蛋白水平的影响[J].中国康复理论与实践.2008,14(11):1059-1061
    [184]下鹏琴,李敬林,王健.眼针对急性脑梗死患者神经功能缺损及血清c-反应蛋白水平的影响[J].针灸临床杂志2007,23(12):23-25
    [185]唐巍,高忻洙.针剌治疗脑卒中作用机制研究进展[J].安徽中医学院学报,2001,20(1):56-59

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