胁腹宁颗粒治疗慢性胆囊炎的药效学研究
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摘要
本课题为胁腹宁颗粒治疗慢性胆囊炎属湿热蕴结证的药效学实验,以明确该病的发病机制及本制剂治疗该病的作用机理。胁腹宁颗粒是长春中医药大学第一附属医院刘铁军教授根据多年临床经验组方而成,作为院内制剂临床已应用多年,疗效确切。该方具有疏肝解郁、行气止痛功效。
实验结果表明:本方具有对胆囊炎细胞浸润有明显抑制作用,有较好的解热镇痛作用,对小鼠的肠蠕动有明显的促进作用。说明本方具有明显的抗炎、利胆等作用,为临床治疗胆囊炎提供了药效学依据。
The prescription is in order to observe the clinical curative effect that the xiefuning granule treats chronic cholecystitis of syndrome of damt-heat ftagnation and carry on researching experiment about pharmacodynamics, make clear the pathogenesis of the disease and mechanism of action of this prescription. Professor Liu Tiejun of the First Affiliated Hospital of Changchun College of Traditional Chinese Medicine succeeded on researching the xiefuning granule by clinical experience of donkey's years. The xiefuning granule has been applied as clinical pharmacy in the First Affiliated Hospital of Changchun College of Traditional Chinese Medicine for donkey's years. It has curative effect exact. This prescription has the efficacy of soothing the Liver and regulating the Circulation of qi and promoting circulation of qi and to relieve pain.
The experiment results show that the prescription restrains the infiltration of chronic cholecystitis cells, has antipyretic and analgesic effects and accelerates the intestiral peristalsis of the mouse obviously. The effect of anti-inflammatory and cholagogic has been proved actively. It offer the basis of pharmacodynamics for chronic cholecystitis on clinical treatment.
实验结果表明:本方具有对胆囊炎细胞浸润有明显抑制作用,有较好的解热镇痛作用,对小鼠的肠蠕动有明显的促进作用。说明本方具有明显的抗炎、利胆等作用,为临床治疗胆囊炎提供了药效学依据。
The prescription is in order to observe the clinical curative effect that the xiefuning granule treats chronic cholecystitis of syndrome of damt-heat ftagnation and carry on researching experiment about pharmacodynamics, make clear the pathogenesis of the disease and mechanism of action of this prescription. Professor Liu Tiejun of the First Affiliated Hospital of Changchun College of Traditional Chinese Medicine succeeded on researching the xiefuning granule by clinical experience of donkey's years. The xiefuning granule has been applied as clinical pharmacy in the First Affiliated Hospital of Changchun College of Traditional Chinese Medicine for donkey's years. It has curative effect exact. This prescription has the efficacy of soothing the Liver and regulating the Circulation of qi and promoting circulation of qi and to relieve pain.
The experiment results show that the prescription restrains the infiltration of chronic cholecystitis cells, has antipyretic and analgesic effects and accelerates the intestiral peristalsis of the mouse obviously. The effect of anti-inflammatory and cholagogic has been proved actively. It offer the basis of pharmacodynamics for chronic cholecystitis on clinical treatment.
引文
[1]周端求.胆石康合剂治疗胆石症临床研究[J].医药研究通讯,1998,27(1):45-46.
[2]麻晓慧.慢性胆囊炎的临床研究现状及评价[J].中国中西医结合脾胃杂志,2000,8(3):192-193.
[3]赵金禄.活血愈胆汤治疗慢性胆囊炎82例.中华实用中西医杂志,2004,VOL.4(17) NO.4,503
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[5]张桂明等.中西医结合治疗慢性胆囊炎89例.实用中西医结合杂志,1995,第8卷,第11期.
[6]李家邦.清肝利湿汤治疗肝胆湿热证的临床研究[J].湖南中医学院学报,1996,16(2):26
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[10]李明杰.辨证治疗慢性胆囊炎60例.四川中医,2000,Vol 18,.No.8:20-21
[11]黄朝阳.周英武.柴胡肝胆舒免煎颗粒治疗慢性胆囊炎75例.2004.Vol.22,No.9:42-43
[12]张晔等.疏肝利胆煎治疗慢性胆囊炎80例.山东中医杂志.2005,VOL.24NO.3:143-144
[13]朱承胜.辨证分型治疗慢性胆囊炎54例疗效观察.新中医,1996,3:28-30
[14]甄丙杜.辨证分型治疗慢性胆囊炎180例疗效观察.河北中医,2001,Vol 23,.No.9:669-670
[15]王波.中医治疗慢性胆囊炎100例[J].实用中医内科杂志,1999,13(1):30.
[16]张晓文.慢性胆囊炎辨治七法[J].中医药研究,1998,.14(15):31-32.
[17]王凤学.血府逐瘀汤加减治疗胆囊炎100例[J].甘肃中医学院学 报,2001,18(2):24.
[18]杨华.仙方活命饮治疗慢性胆囊炎85例[J].河南中医,2001,21(4):39-40.
[19]李学明.利胆活血汤治疗慢性胆囊炎48例[J].河北中医,2002,22(12):935.
[20]刘红英,牛祖智,尹亚君.柴芩丹参汤治疗慢性胆囊炎76例临床观察[J].云南中医中药杂志,2000,21(2):11-12.
[21]卢泓.补中益气汤加味治疗慢性胆囊炎97例.浙江中医杂志.2001.
[22]张友堂.李艳萍.加味大柴胡汤治疗慢性胆囊炎胆石症84例.中国中医药科技.2004,Vol.11 No.6:377
[23]李峰,等.中医研究1995,8(5):26
[24]余靖,张炳厚等.肝胆湿热型慢性胆囊炎一氧化氮、内皮素水平及中药治疗影响.中国中医药信息杂志2001年5月,第8卷,第5期:42-43
[25]夏苏英,李家邦.清肝利湿汤治疗肝胆湿热证的临床研究.湖南中医学院学报,2000,20(3):56-58
[26]孙立忠等.丹栀逍遥散加减治疗慢性胆囊炎急性发作30例疗效观察.中华实用中西医杂志.2005,VOL.(18)NO.3:371
[27]刘学强等.胆复康胶囊治疗慢性胆囊炎临床观察.河南中医.2002,7月,Vol.22,NO.4:33
[28]党中勤.华春肝胆舒治疗慢性胆囊炎120例疗效观察.中国中药杂.2004,Vol.29,NO.2:182
[29]袁平,谢日晶.舒胆2号治疗慢性胆囊炎临床观察.黑龙江中医药.2004.(1)15-16
[30]毛宇湘等.清胆1号治疗慢性胆囊炎的临床研究.中华实用中西医杂志.2004,VOL.4(17)NO.5:651
[31]岳兴如,岳兴太,阮耀.消炎利胆散治疗慢性胆囊炎300例临床观察.国医论坛.2004,VOL19(4):31
[32]王振怀.三金汤治疗慢性胆囊炎50例.山东中医杂志.2000,VOL.19 NO.6:353
[33]张友堂.李艳萍.加味大柴胡汤治疗慢性胆囊炎胆石症84例.中国中医药科技.2004,Vol.11 No.6:377
[34]马骥,刘文洲.中药治疗慢性胆囊炎60例[J].陕西中医学院学报,2000,23(3):19.
[35]喻坚柏,周萍.茵柴利胆汤治疗慢性胆囊炎40例[J]湖南中医杂志,1998,14(3):57.
[36]曾亚庆.胆炎汤治疗慢性非结石性胆囊炎80例[J].实用中医内科杂志,1998,12(4):42-43.
[37]黄晓桃.自拟利胆和胃汤治疗慢性胆囊炎108例[J].实用中医内科杂志,2000,14(4):19.
[38]张明,孙守法,肖玉堂,等.健脾清胆汤治疗慢性胆囊炎疗效观察[J].四川中医,1997,15(3):23.
[39]熊玉钟.应用通降法治疗慢性胆囊炎150例[J].福建中医药,2000,31(3):35-36.
[40]周长芳,朱永生.慢性胆囊炎从胃论治[J].吉林中医药,1999,19(2):35.
[41]张恒录,刘士英.自拟新方胆炎汤治疗慢性胆囊炎102例临床研究.中华医学写作杂志.2003,VOL10.(5):452-453
[42]何容春.柴胡疏肝散加减治疗慢性胆囊炎24例疗效观察.中华实用中西医杂志.2001,VOL.1(14)NO.7:1527
[43]余松辉.柴佛苓术汤治疗慢性胆囊炎31例.新中医.1997,VOL29.(5):40
[44]汪玲.中西医结合治疗慢性胆囊炎137例.陕西中医.1996,17(1):18
[45]顾乃阁,钱道乾,满爱芹.中西医结合治疗慢性胆囊炎100例[J].陕西中医学院学报,2000,23(16):19.
[46]王革,王辉.中西医结合治疗慢性胆囊炎32例[J].山东中医杂志,2000,19(7):421-422.
[47]胡剑秋,周映华.中医综合治疗慢性胆囊炎[J].云南中医中药杂志,1999,21(4):19.
[48]谢业,陈士准.内服外敷法治疗胆囊炎体会[J].江西中医药,1996,27(增刊):51.
[49]孟祥辉,胡静萍.综合疗法治疗慢性胆囊炎100例[J].
[50]邵泽善,邹志宏.胆痹膏治疗慢性胆囊炎的临床观察.2004,13(2):6
[2]麻晓慧.慢性胆囊炎的临床研究现状及评价[J].中国中西医结合脾胃杂志,2000,8(3):192-193.
[3]赵金禄.活血愈胆汤治疗慢性胆囊炎82例.中华实用中西医杂志,2004,VOL.4(17) NO.4,503
[4]陈亚军,陈广平.中西医结合治疗慢性胆囊炎78例.实用中西医结合杂志,1997,第10卷,第9期,871
[5]张桂明等.中西医结合治疗慢性胆囊炎89例.实用中西医结合杂志,1995,第8卷,第11期.
[6]李家邦.清肝利湿汤治疗肝胆湿热证的临床研究[J].湖南中医学院学报,1996,16(2):26
[7]朱培庭.胆道感染及胆石症的中医治疗进展.国内外中医药科技进展.上海:上海科学技术文献出版社,1992,108
[8]陈国林.中医肝病征候临床辩证标准的研究[J].中国医药学报,1990,16(2):26.
[9]周继福等.化痰汤治疗慢性胆囊炎50例.实用中医药杂志.2004,Vol.20.NO.12:680
[10]李明杰.辨证治疗慢性胆囊炎60例.四川中医,2000,Vol 18,.No.8:20-21
[11]黄朝阳.周英武.柴胡肝胆舒免煎颗粒治疗慢性胆囊炎75例.2004.Vol.22,No.9:42-43
[12]张晔等.疏肝利胆煎治疗慢性胆囊炎80例.山东中医杂志.2005,VOL.24NO.3:143-144
[13]朱承胜.辨证分型治疗慢性胆囊炎54例疗效观察.新中医,1996,3:28-30
[14]甄丙杜.辨证分型治疗慢性胆囊炎180例疗效观察.河北中医,2001,Vol 23,.No.9:669-670
[15]王波.中医治疗慢性胆囊炎100例[J].实用中医内科杂志,1999,13(1):30.
[16]张晓文.慢性胆囊炎辨治七法[J].中医药研究,1998,.14(15):31-32.
[17]王凤学.血府逐瘀汤加减治疗胆囊炎100例[J].甘肃中医学院学 报,2001,18(2):24.
[18]杨华.仙方活命饮治疗慢性胆囊炎85例[J].河南中医,2001,21(4):39-40.
[19]李学明.利胆活血汤治疗慢性胆囊炎48例[J].河北中医,2002,22(12):935.
[20]刘红英,牛祖智,尹亚君.柴芩丹参汤治疗慢性胆囊炎76例临床观察[J].云南中医中药杂志,2000,21(2):11-12.
[21]卢泓.补中益气汤加味治疗慢性胆囊炎97例.浙江中医杂志.2001.
[22]张友堂.李艳萍.加味大柴胡汤治疗慢性胆囊炎胆石症84例.中国中医药科技.2004,Vol.11 No.6:377
[23]李峰,等.中医研究1995,8(5):26
[24]余靖,张炳厚等.肝胆湿热型慢性胆囊炎一氧化氮、内皮素水平及中药治疗影响.中国中医药信息杂志2001年5月,第8卷,第5期:42-43
[25]夏苏英,李家邦.清肝利湿汤治疗肝胆湿热证的临床研究.湖南中医学院学报,2000,20(3):56-58
[26]孙立忠等.丹栀逍遥散加减治疗慢性胆囊炎急性发作30例疗效观察.中华实用中西医杂志.2005,VOL.(18)NO.3:371
[27]刘学强等.胆复康胶囊治疗慢性胆囊炎临床观察.河南中医.2002,7月,Vol.22,NO.4:33
[28]党中勤.华春肝胆舒治疗慢性胆囊炎120例疗效观察.中国中药杂.2004,Vol.29,NO.2:182
[29]袁平,谢日晶.舒胆2号治疗慢性胆囊炎临床观察.黑龙江中医药.2004.(1)15-16
[30]毛宇湘等.清胆1号治疗慢性胆囊炎的临床研究.中华实用中西医杂志.2004,VOL.4(17)NO.5:651
[31]岳兴如,岳兴太,阮耀.消炎利胆散治疗慢性胆囊炎300例临床观察.国医论坛.2004,VOL19(4):31
[32]王振怀.三金汤治疗慢性胆囊炎50例.山东中医杂志.2000,VOL.19 NO.6:353
[33]张友堂.李艳萍.加味大柴胡汤治疗慢性胆囊炎胆石症84例.中国中医药科技.2004,Vol.11 No.6:377
[34]马骥,刘文洲.中药治疗慢性胆囊炎60例[J].陕西中医学院学报,2000,23(3):19.
[35]喻坚柏,周萍.茵柴利胆汤治疗慢性胆囊炎40例[J]湖南中医杂志,1998,14(3):57.
[36]曾亚庆.胆炎汤治疗慢性非结石性胆囊炎80例[J].实用中医内科杂志,1998,12(4):42-43.
[37]黄晓桃.自拟利胆和胃汤治疗慢性胆囊炎108例[J].实用中医内科杂志,2000,14(4):19.
[38]张明,孙守法,肖玉堂,等.健脾清胆汤治疗慢性胆囊炎疗效观察[J].四川中医,1997,15(3):23.
[39]熊玉钟.应用通降法治疗慢性胆囊炎150例[J].福建中医药,2000,31(3):35-36.
[40]周长芳,朱永生.慢性胆囊炎从胃论治[J].吉林中医药,1999,19(2):35.
[41]张恒录,刘士英.自拟新方胆炎汤治疗慢性胆囊炎102例临床研究.中华医学写作杂志.2003,VOL10.(5):452-453
[42]何容春.柴胡疏肝散加减治疗慢性胆囊炎24例疗效观察.中华实用中西医杂志.2001,VOL.1(14)NO.7:1527
[43]余松辉.柴佛苓术汤治疗慢性胆囊炎31例.新中医.1997,VOL29.(5):40
[44]汪玲.中西医结合治疗慢性胆囊炎137例.陕西中医.1996,17(1):18
[45]顾乃阁,钱道乾,满爱芹.中西医结合治疗慢性胆囊炎100例[J].陕西中医学院学报,2000,23(16):19.
[46]王革,王辉.中西医结合治疗慢性胆囊炎32例[J].山东中医杂志,2000,19(7):421-422.
[47]胡剑秋,周映华.中医综合治疗慢性胆囊炎[J].云南中医中药杂志,1999,21(4):19.
[48]谢业,陈士准.内服外敷法治疗胆囊炎体会[J].江西中医药,1996,27(增刊):51.
[49]孟祥辉,胡静萍.综合疗法治疗慢性胆囊炎100例[J].
[50]邵泽善,邹志宏.胆痹膏治疗慢性胆囊炎的临床观察.2004,13(2):6