摘要
在传统医学发展的历史长河中,一些如波斯,阿拉伯和中国的医学扮演了十分重要的角色。在九、十世纪间,中国和这些中东国家对医学知识的交流尤其频繁,其中也包括来自欧洲一些国家的相关知识,使得亚洲大陆两端地区的治疗技术更为丰富,而就因为如此,在当时的葡萄牙药店里,我们能找到来自中国的药物,并在十八世纪葡萄牙的许多医学资料中也能查到一系列关于很多来自于东方动植物药品的记载。葡萄牙耶稣会士在澳门的圣保禄学院对这些药物进行了亲身的试验和使用,因此他们对这些药物的宣传和引进起着至关重要的作用。鉴于这些历史事件,我们尝试通过研究葡萄牙人和中国人对石蚕的认识,分析中国和葡萄牙两国之间在医学上的相互影响,进而产生了一种新的混合医学的过程。
本论文共为五章
第一章中葡医学交流状况:中葡医学用药交流的历史介绍、十六世纪澳门医疗状况、澳门圣保禄学院的秘方、澳门耶稣会士秘方中中西医并用情况、澳门耶稣会士秘方对葡萄牙药学著作的影响。
第二章历史上石蚕的应用状况:古代葡萄牙文献中石蚕用于发烧的状况、石蚕在葡萄牙主要药学著作中的记载、石蚕在中国主要药学著作中的记载、对石蚕品种的认识和讨论。
第三章石蚕在世界其他各国的现代研究状况:英文文献对于Teucrium和Stachys的认识。
第四章石蚕在中国的现代应用和研究状况:中文文献对于Teucrium和Stachys的认识。
第五章讨论和总结:(1)中葡古代书籍对石蚕的认识:从古今中葡医学书籍中对石蚕认识状况的分析,我们可推断中国和葡萄牙两国在用药上的间接相互影响。这种间接影响主要由阿拉伯人于五、六世纪前后与东、西方同时进行贸易及文化交流时开始。阿拉伯人和世界各地交往联系之中的成果之一,就是他们对许多国家的医学及植物的应用所产生的影响,如葡萄牙医学和中国医学对石蚕的认识。通过研究石蚕的古今记载我们能确认中医和葡萄牙医学之间的这种间接相互影响。(2)世界各国关于石蚕化学成分、毒性成分、临床应用及药理作用的研究:从研究结果我们可以证实知道,石蚕不管归类于Teucrium还是Stachys,这两种药物都具有类似化学成分及重要的临床价值,可用于治疗一系列常见疾病,如癌症和各种炎症、糖尿病等。
希望这篇论文可以重新引起中国科研人员对石蚕进一步的重视,并能够挖掘出对于其他疾病可能具有的治疗功效,从而对中国现代医学作出贡献。
All throughout the worldwide development history of traditional healing practices, the persian, arab, greek and chinese medicines played a fundamental and important role in the use of medicinal plants. The highlights of such outgrow were mainly intensified starting from the 9th and 10th centuries AD. While an exchange of medical knowledge started to exist between China and several Arab speaking countries even before, part of such expertise had also undoubtedly been inherited from the mediterranean world, thus this east-west interchange enabled the art of healing on both extremes of the asian continent to become ever richer. Thus, it's difficult even when nowadays one tries to analyze different chinese remedies the portuguese used in medicine (16/17/18th century), since Europe (specially the southwest) had also received an earlier arab influence as well as China, thus also determining both east and west medical practices. Still, several portuguese herbal classical written works of the 18th century list such an immensity of medicinal plants of asian origin. In the process of introduction and exchange of western medical knowledge in China, one must not however discard the crucial role the portuguese Jesuits had in promoting and introducing new experimental ways as herbs were tested and utilized in their own colleges, infermeries and apothecaries, specially after the arrival of the Jesuit order to Macao and consequent construction of the Saint Paul's college (first western university in Asia). Under such historical base and through the analysis of one medicinal plant:Teucrium sp(石蚕),across this study, we purpose to trace back the mutual influence in the area of medical sciences either in China and Portugal, using this herb has a reference for the appearance of a mixed or integrated kind of medicine.
This thesis is composed of 5 chapters:
Chapter 1. Researching the mutual influence in traditional medicines, in Portugal and China:Historical introduction, Interchange process between western and chinese medicines started in 16th century Macao; Secret herbal formulas of the Jesuits from the St. Paul's College in Macao; The use of herbal medicines of oriental and western origin used by the jesuits; The influence this mixed medicine created by the Jesuits in Macao had in the portuguese pharmacopeas.
Chapter 2. Historical background of the medicinal herb Teucrium(石蚕)Teucrium(石蚕)in the treatment of fever according with the Portuguese references; Research on Teucrium(石蚕)in the portuguese herbal medicine classical written works; Study of Teucrium(石蚕)in chinese herbal medicine classical written works; The classification and use of Teucrium(石蚕)according to contemporary chinese bibliography.
Chapter 3. West clinical usage of Teucrium(石蚕)Research study on international english written articles referring Teucrium and Stachys.
Chapter 4. Chinese clinical usage of Teucrium(石蚕)Research study on chinese published articles referring Teucrium(石蚕).
Chapter 5. Discussion and Conclusion:
Conclusion over the discussion on the classical portuguese and chinese botanical-medical knowledge over the plant, Teucrium(石蚕)Analyzing the portuguese and chinese herbal classical data, we conclude the expertise both of these medical systems hold about the plant(石蚕)may reflect that a mutual influence existed in the area of herbal medicine between China and the west, manly through an earlier interchange with arab speaking countries (during the 9th and 10th centuries A.D.), and such influence is predominately seen as result of the clinical usage of the plant.
Discussion and conclusion over the contemporary scientific knowledge China and the rest of the world have concerning Teucrium sp. and Stachys sp. From the analysis of several published articles covering studies on both these medicinal plants, we come to the conclusion that regardless石蚕is classified as Teucrium sp. or Stachys sp., both hold essentially the same chemical constituents and have an extensive clinical value when dealing with a whole range of diseases considered difficult to treat such as cancer, diabetes, rheumatism, etc. Unfortunately, such species of medicinal plants among the chinese scientific community, the researchs for both Teucrium sp. and Stachys sp. has yet to flourish.
We hope this research will serve to incentive the chinese scientists and doctors to recognize the clinical and scientific value of石蚕so it may become an important bibliographic key reference on the contemporary herbal knowledge, thus contributing to improve the therapeutical efficacy when dealing with various diseases forthcoming an advancement of chinese medicine.
引文
[1]董少新.形神之间·早期西洋医学如华史稿[M].上海:上海古籍出版社,2008,69.
[2]董少新.形神之间·早期西洋医学如华史稿[M].上海:上海古籍出版社,2008,78.
[3]BA, Jesuitas na Asia, Cod.49-V-66,fl.17v.
[4]董少新.形神之间·早期西洋医学如华史稿[M].上海:上海古籍出版社,2008,85.
[5]AMARO, Ana Maria. Contribuicdo para o Estudo de Flora Macaense[M]. Macao: Imprensa Nacional,1976.
[6]董少新.形神之间·早期西洋医学如华史稿[M].上海:上海古籍出版社,2008,16.
[7]AMARO, Ana Maria. Medicina Popular de Macau-um processo de adaptacao cultural[M]. Lisboa,1986.
[8]AMARO, Ana Maria. The influence of Monastery Dispensaries on Folk Medicine in Macao [M]. Macao:Review of Culture,1995.
[9]Collecao das Varias Receitas e Segredos pariculares das principals boticas da nossa Companhia de Portugal, da India, de Macao e do Brasil compostos e experimentadas pelos melhores Medicos, e Boticarios masi celebres que tem havido nessas partes. Aumentada com alguns indices e noticias curiosas necessarias para a boa direccao e acerto contra enfermidades, Roma,1766. ARSI (Archivum Romanum Societatis ISEU), Cod., OPP. NN17, paginas (I-XVIII)-610(Ⅰ-IX):68.
[10]董少新.形神之间·早期西洋医学如华史稿[M].上海:上海古籍出版社,2008,65.
[11]AMARO, Ana Maria.Introducao da Medicina Ocidental em Macau e as receitas de segredo da Botica do Colegio de Sao Paulo[M]. Macau:Instituto Cultural de Macau,1992.
[12]董少新.形神之间·早期西洋医学如华史稿[M].上海:上海古籍出版社,2008,113.
[13]董少新.形神之间·早期西洋医学入华史稿[M],112:《明清时期澳门问题档案文献汇编》第一册,第85页。康熙四十八年正月初五日“两广总督赵弘灿等奏为遵旨恭进西洋药格而墨斯折”中内容略同,参见中国第一历史档案馆编:《康熙朝汉文朱批奏折汇编》第二册,298-302.
[14]清.赵学敏.本草纲目抬遗[M].北京:人民卫生出版社,1983,361.
[15]唐.苏敬等编尚志钧辑校.新修本草[M].安徽:安徽科技出版社,1981.
[16]明.李时珍.本草纲目(下)[M].上海:上海科学技术出版社,2008,1739.
[17]董少新.形神之间·早期西洋医学入华史稿[M].147:中国第一史档案馆编:《康熙朝满 文朱批秦析全译》,43.
[18]董少新.形神之间·早期西洋医学入华史稿[M].上海:上海古籍出版社,2008,49.
[19]Mira, Ferreira de. Historia da Medicina Portuguesa[M]. Lisboa:Emprensa Nacional, 1948,126,133.
[20]清.赵学敏.漆浩张瑞贤主编.本草纲目抬遗[M].北京:学苑出版社,1994,46.
[21]VIGIER, Joao(约翰.维克尔)Farmacopeia Ulissiponense, Farmacopeia (药典) Ulissiponense(古代里斯本的名字、[M]. Lisboa:Impressor de St. Magestade,1756.
[22]DIOSCORIDES, Pedanius(狄欧斯考里德斯)Materia Medica(药物学)[M]. Madrid: En casa de Iuan Latio,1555.
[23]DIOSCORIDES, Pedanius(狄欧斯考里德斯)Materia Medica(药物学)[M]. Madrid: En casa de Iuan Latio,1555,343.
[24]DIOSCORIDES, Pedanius(狄欧斯考里德斯)Materia Medica(药物学)[M]. Madrid: En casa de Iuan Latio,1555,335.
[25]DIOSCORIDES, Pedanius(狄欧斯考里德斯)Materia Medica(药物学)[M]. Madrid: En casa de Iuan Latio,1555,339.
[26]LOUREIRO, Joao de(约翰·德·洛雷罗)Flora Conchinsinensis(东南亚植物群)[M].Lisboa:Jussu Acad. R. Scient.,1790.
[27]LOUREIRO, Joao de(约翰·德·洛雷罗)Flora Conchinsinensis(东南亚植物群)[M].Lisboa:Jussu Acad. R. Scient.,1790,362.
[28]LOUREIRO, Joao de(约翰·德·洛雷罗)Flora Conchinsinensis(东南亚植物群)[M].Lisboa:Jussu Acad. R. Scient.,1790.
[29]魏.吴普等述.神农本草经[M].山西:山西科学技术出版社,2010,229.
[30]唐.苏敬等撰.新修本草[M].上海:中国古典医学丛刊,1985,253.
[31]梁.陶弘景集.名医别录[M].北京:人民卫生出版社,1986,287.
[32]梁.陶弘景编.本草经集注[M].人民卫生出版社,1994,397.
[33]宋.苏颂编撰.本草图经[M].安徽:安徽科学技术出版社,1994,507.
[34]元.忽思慧撰.饮膳正要[M].北京:人民卫生出版社,1986,146.
[35]明.李时珍.本草纲目[M].北京:人民卫生出版社,2007,1683.
[36]清.吴其浚著.植物名实图考[M].上海:商务印书馆出版,1957,100,409.
[37]贵州省中医研究所编.贵州草药[M].贵州:人民出版社,1970.
[38]清.赵学敏.纲目抬遗[M].上海:商务印书馆出版,1954,166.
[39]谢宗万编撰.汉拉英对照中药材正名词典[M].北京:北京科学技术出版社,2004,1.1363,7.844,1.1364,1.1365,7.845,7.846.
[40]谢宗万 余友芩 主编.全国中草药名鉴下册·中国中医研究院中药研究所[M].北京:人民卫生出版社,1996,547,703.
[41]李薇,喻良文 主编.名贵珍稀鉴别图册[M].广东:广东科技术出版社,2009,102.
[42]李衍文 编.汉拉英中草药名称词典[M].广东:广东科技书出版社,1998,586,337:
[43]侯士良 主编.中药八百种详解[M].河南:河南科学技术出版社,2009,80,102.
[44]李建生,郝近大 主编.解药图谱[M].北京:中国医药科技出版社,2009,19.
[45]王锦鸿 主编.临床实用中药辞典[M].北京:金盾出版社,2003,0247.
[46]李衍文 主编.中草药异名词典[M].北京:人民卫生出版社,2004,971.
[47]朱建平 主编.中药名考证与规范[M].上海:中国古籍出版社,2000,289,373.
[48]中国中草药汇编主编.全国中草药汇编彩色图谱[M].北京:人民卫生出版社,1997,247.
[49]刘道清 主编.中草别名大辞典[M].郑州:中原农民出版社,1999,77.
[50]Aravind S, Balachandran J, Ramanujam Ganesh M, Krishna Kumari GN. Further anti-feedant neo-clerodanes from Teucrium tomentosum [J]. Nat Prod Res,2010;24(1):7-12.
[51]Formisano C, Rigano D, Senatore F, Al-Hillo MR, Piozzi F, Rosselli S. Analysis of essential oil from Teucrium maghrebinum Greuter et Burdet growing wild in Algeria [J]. Nat Prod Commun,2009;4(3):411-4.
[52]Ozel MZ, Gogiis F, Lewis AC. Determination of Teucrium chamaedrys volatiles by using direct thermal desorption-comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry [J]. J Chromatogr A.,2006;1114(1):164-9.
[53]Kisiel W, Piozzi F, Grzybek J. Terpenoids from Teucrium montanus subsp. Pannonicum [J]Planta Med.,1995;61(2):191-2.
[54]J Kandouz M, Alachkar A, Zhang L, Dekhil H, Chehna F, Yasmeen A, Al Moustafa AE. Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex [J].Ethnopharmacol,2010;129(3): 410-5.
[55]Kasabri V, Afifi FU, Hamdan I. In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine[J]. J Ethnopharmacol,2011;133(2):888-96.
[56]Afifi FU, Al-Khalidi B, Khalil E. Studies on the in vivo hypoglycemic activities of two medicinal plants used in the treatment of diabetes in Jordanian traditional medicine following intranasal administration[J]. J Ethnopharmacol,2005;100(3):314-8.
[57]Elayan HH, Salhab AS, Gharaibeh MN. Hypoglycemic effects of Teucrium polium [J]. J Ethnopharmacol,1988;24(1):93-9.
[58]Yaniv Z, Dafni A, Friedman J, Palevitch D. Plants used for the treatment of diabetes in Israel[J].J Ethnopharmacol,1987; 19(2):145-51.
[59]Al-Mustafa AH, Al-Thunibat OY. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes [J]. J Ethnopharmacol,1988,24(1); 93-9.
[60]Gharaibeh MN, Elayan HH, Salhab AS. Hypoglycemic effects of Teucrium polium [J]. Pak J Biol Sci.,2008;11(3):351-8.
[61]Ben Sghaier M, Chraief I, Skandrani I, Bouhlel I, Boubaker J, Kilani S, Neffati A, Mahmoud A, Hammami M, Chekir-Ghedira L, Ghedira K. Chemical composition and antimicrobial activity of the essential oil of Teucrium ramosissimum (Lamiaceae)[J].Chem Biodivers,2007;4(7):1480-6.
[62]Baluchnejadmojarad T, Roghani M, Roghani-Dehkordi F. Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test [J]. J Ethnopharmacol,2005;97(2):207-10.
[63]Esmaeili MA, Yazdanparast R. Hypoglycaemic effect of Teucrium polium:studies with rat pancreatic islets [J]. J Ethnopharmacol,2004;95(1):27-30.
[64]Rasekh HR, Khoshnood-Mansourkhani MJ, Kamalinejad M. Hypolipidemic effects of Teucrium polium in rats [J]. Fitoterapia,2001;72(8):937-9.
[65]Amini R, Yazdanparast R, Aghazadeh S, Ghaffari SH. Teucrium polium reversed the MCD diet-induced liver injury in rats [J]. Hum Exp Toxicol,2010.
[66]Nosrati N, Aghazadeh S, Yazdanparast R. Effects of Teucrium polium on Insulin Resistance in Nonalcoholic Steatohepatitis [J]. J Acupunct Meridian Stud,2010;3(2):104-10.
[67]Aghazadeh S, Yazdanparast R.Clin. Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats [J]..Nutr.,2010;29(3):381-5.
[68]Amini R, Nosrati N, Yazdanparast R, Molaei M. Teucrium polium in prevention of steatohepatitis in rats [J]. Liver Int.,2009;29(8):1216-21.
[69]Panovska TK, Kulevanova S., Gjorgoski I., Bogdanova M., Petrushevska G.. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats [J]. Acta Pharm.,2007;57(2):241-8.
[70]Ben Sghaier M, Bhouri W, Neffati A, Boubaker J, Skandrani I, Bouhlel I, Kilani S, Chekir-Ghedira L, Ghedira K.Chemical investigation of different crude extracts from Teucrium ramosissimum leaves. Correlation with their antigenotoxic and antioxidant properties [J]. Food Chem Toxicol,2011;49(1):191-201.
[71]Sghaier MB, Boubaker J, Neffati A, Limem I, Skandrani I, Bhouri W, Bouhlel I, Kilani S, Chekir-Ghedira L, Ghedira K. Antimutagenic and antioxidant potentials of Teucrium ramosissimum essential oil [J]. Chem Biodivers,2010, (7)7; 1754-63.
[72]Yin G, Zeng H, He M, Wang M. Extraction of Teucrium manghuaense and evaluation of the bioactivity of its extract [J]. Int J Mol Sci.,2009;10(10):4330-41.
[73]Kandouz M, Alachkar A, Zhang L, Dekhil H, Chehna F, Yasmeen A, Al Moustafa AE. Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex [J].J Ethnopharmacol,2010; 129(3): 410-5.
[74]BaniHani MN, Al Manasra AR. Spontaneous regression in alveolar soft part sarcoma: case report and literature review [J].World J Surg Oncol,2009;7:53.
[75]Rajabalian S. Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines [J].Exp Oncol,2008;30(2):133-8.
[76]Tepe B, Degerli S, Arslan S, Malatyali E, Sarikurkcu C. Determination of chemical profile, antioxidant, DNA damage protection and antiamoebic activities of Teucrium polium and Stachys iberica[J]. Fitoterapia,2010.
[77]Fernandez Puntero B, Iglesias Peinado I, Villar del Fresno AM. Anti-inflammatory and antiulcer activity of Teucrium buxifolium [J]. JEthnopharmacol,1997;55(2):93-8.
[78]Mehrabani D, Rezaee A, Azarpira N, Fattahi MR, Amini M, Tanideh N, Panjehshahin MR, Saberi-Firouzi M. The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats [J]. Saudi Med J.,2009;30(4):494-9.
[79]Al-Mustafa AH, Al-Thunibat OY. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes [J]. J Ethnopharmacol,1988;24(1):93-9.
[80]Khader M, Bresgen N, Eckl PM. Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants [J]. J Ethnopharmacol,2010;127(2):319-24.
[81]Ljubuncic P, Azaizeh H, Portnaya I, Cogan U, Said O, Saleh KA, Bomzon A. Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel[J].J Ethnopharmacol,2005;99(1):43-7.
[82]Tariq M, Ageel AM, al-Yahya MA, Mossa JS, al-Said MS. Anti-inflammatory activity of Teucrium polium [J]. Int J Tissue React,1989; 11 (4):185-8.
[83]Vukovic N, Milosevic T, Sukdolak S, Solujic S. Antimicrobial Activities of Essential Oil and Methanol Extract of Teucrium montanum [J]. Evid Based Complement Alternat Med.,2007;4(1):17-20.
[84]Ben Sghaier M, Chraief I, Skandrani I, Bouhlel I, Boubaker J, Kilani S, Neffati A, Mahmoud A, Hammami M, Chekir-Ghedira L, Ghedira K. Chemical composition and antimicrobial activity of the essential oil of Teucrium ramosissimum (Lamiaceae)[J].Chem Biodivers,2007;4(7):1480-6.
[85]Salah KB, Mahjoub MA, Chaumont JP, Michel L, Millet-Clerc J, Chraeif I, Ammar S, Mighri Z, Aouni M. Chemical composition and in vitro antifungal and antioxidant activity of the essential oil and methanolic extract of Teucrium sauvagei Le Houerou [J]. Nat Prod Res.2006;20(12):1089-97.
[86]Djilas SM, Markov SL, Cvetkovic DD, Canadanovic-Brunet JM, Cetkovic GS, Tumbas VT. Antimicrobial and free radical scavenging activities of Teucrium montanum [J]. Fitoterapia,2006;77(5):401-3.
[87]Autore G, Capasso F, De Fusco R, Fasulo MP, Lembo M, Mascolo N, Menghini A. Antipyretic and antibacterial actions of Teucrium polium (L.) [J]. Pharmacol Res Commun,1984;16(1):21-9.
[88]Darwish RM, Aburjai TA. Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli[J]. BMC Complement Altern Med.,2010;10:9.
[89]Mothana RA, Gruenert R, Bednarski PJ, Lindequist U. Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in folk medicine[J].Pharmazie,2009;64(4):260-8
[90]Mothana RA, Lindequist U, Gruenert R, Bednarski PJ. Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra [J]. BMC Complement Altern Med.,2009;9:7.
[91]Motamedi H, Darabpour E, Gholipour M, Seyyed Nejad SM. In vitro assay for the anti-Brucella activity of medicinal plants against tetracycline-resistant Brucella melitensis [J]. J Zhejiang Univ Sci B.,2010;11(7):506-11.
[92]Kim SH, Park SB, Kang SM, Jeon H, Lim JP, Kwon TK, Park WH, Kim HM, Shin TY. Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model [J]. Food Chem Toxicol,2009;47(2):398-403.
[93]Azaizeh H, Ljubuncic P, Portnaya I, Said O, Cogan U, Bomzon A. Fertilization-induced changes in growth parameters and antioxidant activity of medicinal plants used in traditional Arab medicine [J]. Evid Based Complement Alternat Med.,2005;2(4):549-56.
[94]Fiorentino A, D'Abrosca B, Pacifico S, Scognamiglio M, D'Angelo G, Monaco P. Bioorg. Abeo-abietanes from Teucrium polium roots as protective factors against oxidative stress [J]. Med Chem.,2010;18(24):8530-6.
[95]Abdolghaffari AH, Baghaei A, Moayer F, Esmaily H, Baeeri M, Monsef-Esfahani HR, Hajiaghaee R, Abdollahi M. On the benefit of Teucrium in murine colitis through improvement of toxic inflammatory mediators [J]. Hum Exp Toxicol.,2010;29(4):287-95.
[96]Esmaeili MA, Zohari F, Sadeghi H. Antioxidant and protective effects of major flavonoids from Teucrium polium on beta-cell destruction in a model of streptozotocin-induced diabetes [J].Planta Med.,2009;75(13):1418-20.
[97]Al-Mustafa AH, Al-Thunibat OY. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes [J]. Pak J Biol Sci.,2008;11(3):351-8.
[98]Ardestani A, Yazdanparast R, Jamshidi Sh.Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induced diabetic rats[J]. J Med Food.,2008;11(3):525-32.
[99]Mehrabani D, Rezaee A, Azarpira N, Fattahi MR, Amini M, Tanideh N, Panjehshahin MR, Saberi-Firouzi M. The healing effects of Teucrium polium in the repair of indomethacin-induced gastric ulcer in rats [J]. Saudi Med J.,2009;30(4):494-9.
[100]Orhan I, Aslan M. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants[J]. Turkey.Erratum in:J Ethnopharmacol,2011;133(1):251.
[101]Couladis M, Tzakou O, Verykokidou E, Harvala C. Screening of some Greek aromatic plants for antioxidant activity [J]. Phytother Res.2003;17(2):194-5.
[102]Dilsiz N, Sahaboglu A, Yildiz MZ, Reichenbach A. Graefes. Protective effects of various antioxidants during ischemia-reperfusion in the rat retina [J]. Arch Clin Exp Ophthalmol. 2006,244(5):627-33.
[103]Wassel GM, Ahmed SS. GLC-mass spectrometry of Teucrium polium oil [J]. J Pharm Sci.,1979;68(6):800-1.
[104]Saric-Kundalic B, Dobes C, Klatte-Asselmeyer V, Saukel J. Ethnobotanical study on medicinal use of wild and cultivated plants in middle, south and west Bosnia and Herzegovina[J]. J Ethnopharmacol.,2010; 131 (1):33-55
[105]Rabbani M, Sajjadi SE, Jalali A. Hydroalcohol extract and fractions of Stachys lavandulifolia Vahl:effects on spontaneous motor activity and elevated plus-maze behaviour [J]. Phytother Res.,2005;19(10):854-8.
[106]Muntean D, Vari CE, Imre S, Dogaru MT. Qualitative determination of flavonoids and phenol-carboxylic acids of indigene Stachys species using HPLC method [J]. Rev Med Chir Soc Med Nat Iasi.,2004; 108(3):712-7.
[107]Murata T, Endo Y, Miyase T, Yoshizaki F. Iridoid glycoside constituents of Stachys lanata [J]. J Nat Prod.,2008;71(10):1768-70.
[108]Ali NA, Marongiu B, Piras A, Porcedda S, Falconieri D, Molicotti P, Zanetti S. Essential oil composition of leaves of Stachys yemenensis obtained by supercritical [J]. Nat Prod Res., 2010;24(19):1823-9
[109]Cavar S, Maksimovic M, Vidic D, Solic ME. Chemical composition of the essential oil of Stachys menthifolia Vis [J].Pharm Biol,2010;48(2):170-6.
[110]Maleki-Dizaji N, Nazemiyeh H, Maddah N, Mehmani F, Garjani A. Screening of extracts and fractions from aerial parts of Stachys schtschegleevii Sosn.for anti-inflammatory activities [J]. Pak J Pharm Sci,2008;21(4):338-43.
[111]Maleki N, Garjani A, Nazemiyeh H, Nilfouroushan N, Eftekhar Sadat AT, Allameh Z, Hasannia N. Potent anti-inflammatory activities of hydroalcoholic extract from aerial parts of Stachys inflata on rats [J]. J Ethnopharmacol,2001;75(2-3):213-8.
[112]Khanavi M, Sharifzadeh M, Hadjiakhoondi A, Shafiee A. Phytochemical investigation and anti-inflammatory activity of aerial parts of Stachys byzanthina C. Koch. [J]. J Ethnopharmacol.,2005;97(3):463-8.
[113]Skaltsa H, Bermejo P, Lazari D, Silvan AM, Skaltsounis AL, Sanz A, Abad MJ. Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida [J].Biol Pharm Bull.2000,23(1); 47-53.
[114]Hayashi K, Nagamatsu T, Ito M, Hattori T, Suzuki Y. Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent (2):Effect of acteoside on leukocyte accumulation in the glomeruli of nephritic rats [J]. Jpn J Pharmacol,1994;66(1):47-52.
[115]Hayashi K, Nagamatsu T, Ito M, Yagita H, Suzuki Y. Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent (3):effect of aceteoside on expression of intercellular adhesion molecule-1 in experimental nephritic glomeruli in rats and cultured endothelial cells [J]. Jpn J Pharmacol,1996;70(2):157-68.
[116]Ozturk M, Duru ME, Aydogmus-Ozturk F, Harmandar M, Mahlicli M, Kolak U,Ulubelen A.GC-MS analysis and antimicrobial activity of essential oil of Stachys cretica subsp. Smyrnaea [J]. Nat Prod Commun.,2009;4(1):109-14.
[117]Ivanova A, Nechev J, Tsvetkova I, Stefanov K, Popov S. Chemical composition of the halophyte plant Stachys maritima Gouan from the Bulgarian Black Sea coast [J]. Nat Prod Res,2009;23(5):448-54.
[118]Saeedi M, Morteza-Semnani K, Mahdavi MR, Rahimi F. Antimicrobial studies on extracts of four species of stachys [J]. Indian J Pharm Sci,2008;70(3):403-6.
[119]Skaltsa HD, Demetzos C, Lazari D, Sokovic M. Essential oil analysis and antimicrobial activity of eight Stachys species from Greece [J]. Phytochemistry,2003;64(3):743-52.
[120]J Stamatis G, Kyriazopoulos P, Golegou S, Basayiannis A, Skaltsas S, Skaltsa H. In vitro anti-Helicobacter pylori activity of Greek herbal medicines [J]. J Ethnopharmacol,2003;88(2-3):175-9.
[121]Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K. Immunomodulatory and apoptotic effects of Stachys obtusicrena on proliferative lymphocytes [J]. Med Sci Monit,2007; 13(6):BR145-50.
[122]Voitenko GN, Umel' VB, Tarapon OIu, Zosim GL.Use of stachyrene in combined treatment of patients with obstructive jaundice. Klin Khir.,1990;(11):26-7.
[123]Shin TY. Stachys riederi inhibits mast cell-mediated acute and chronic allergic reactions [J]. Immunopharmacol Immunotoxicol,2004;26(4):621-30.
[124]Amirghofran Z. Medicinal plants as immunosuppressive agents in traditional Iranian medicine [J]. Imunoinibitoria. Iran J Immunol,2010;7(2):65-73.
[125]J Stamatis G, Kyriazopoulos P, Golegou S, Basayiannis A, Skaltsas S, Skaltsa H. In vitro anti-Helicobacter pylori activity of Greek herbal medicines [J]. Ethnopharmacol,2003;88(2-3):175-9.
[126]Di Giorgio C, Delmas F, Tueni M, Cheble E, Khalil T, Balansard G. Alternative and complementary antileishmanial treatments:assessment of the antileishmanial activity of 27 Lebanese plants, including 11 endemic species [J]. J Altern Complement Med.,2008;14(2): 157-62.
[127]Cavar S, Maksimovic M, Vidic D, Solic ME. Chemical composition of the essential oil of Stachys menthifolia Vis [J].Pharm Biol,2010;48(2):170-6.
[128]Haznagy-Radnai E, Czigle S, Zupko I, Falkay G, Mathe I. Comparison of antioxidant activity in enzyme-independent system of six Stachys species [J]. Fitoterapia,2006;77(7-8):521-4.
[129]Kukic J, Petrovic S, Niketic M. Antioxidant activity of four endemic Stachys taxa [J].Biol Pharm Bull,2006;29(4):725-9.
[130]Erdemoglu N, Turan NN, Cakici I, Sener B, Aydin A. Antioxidant activities of some Lamiaceae plant extracts [J]. Phytother Res,2006;20(1):9-13.
[131]Couladis M, Tzakou O, Verykokidou E, Harvala C. Screening of some Greek aromatic plants for antioxidant activity [J]. Phytother Res.,2003; 17(2):194-5.
[132]Chen P, Lin LZ, Harnly JM. Mass spectroscopic fingerprinting method for differentiation between Scutellaria lateriflora and the germander (Teucrium canadense and T. chamaedrys) species [J].J AOAC Int.,2010;93(4):1148-54.
[133]Herrera S, Bruguera M. Hepatotoxicity induced by herbs and medicines used to induce weight loss [J]. Gastroenterol Hepatol,2008;31(7):447-53.
[134]Poon WT, Chau TL, Lai CK, Tse KY, Chan YC, Leung KS, Chan YW. Hepatitis induced by Teucrium viscidum [J]. Clin Toxicol (Phila),2008;46(9):819-22.
[135]Chitturi S, Farrell GC. Hepatotoxic slimming aids and other herbal hepatotoxins [J]. J Gastroenterol Hepatol,2008;23(3):366-13.
[136]Starakis I, Siagris D, Leonidou L, Mazokopakis E, Tsamandas A, Karatza C.; Hepatitis caused by the herbal remedy Teucrium polium L. [J]. Eur J Gastroenterol Hepatol,2006;18(6):681-3.
[137]Mazokopakis EE, Papadakis JA, Kofteridis DP. Unusual causes of intrahepatic cholestatic liver disease [J]. World J Gastroenterol,2007; 13(12):1879-82.
[138]Savvidou S, Goulis J, Giavazis I, Patsiaoura K, Hytiroglou P, Arvanitakis C. Herb-induced hepatitis by Teucrium polium L.:report of two cases and review of the literature [J]. Eur J Gastroenterol Hepatol,2007;19(6):507-11.
[139]Pauwels A, Thierman-Duffaud D, Azanowsky JM, Loiseau D, Biour M, Levy VG. Acute hepatitis caused by wild germander. Hepatotoxicity of herbal remedies. Two cases [J]. Gastroenterol Clin Biol,1992;16(1):92-5.
[140]Stickel F, Egerer G, Seitz HK.Department of Medicine and Gastroenterology, Krankenhaus der Barmherzigen Briider [J]. Public Health Nutr.,2000;3(2):111.
[141]Panovska TK, Kulevanova S, Gjorgoski I, Bogdanova M, Petrushevska G. Hepatoprotective effect of the ethyl acetate extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats [J]. Acta Pharm.,2007;57(2):241-8.
[142]Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ. Herbal bioactivation:the good, the bad and the ugly [J]. Life Sci,2004;74(8):935-68.
[143]Zhang qian jun, Mou ming yue, Bai song, Chen qing, Yao rong jun. Study on Liposoluble Constituents if Teucrium labiosum[J].中药材,2008;(31)7:1004.
[144]孙迪安,李广义.香科科属植物中二萜类研究进展[J].天然产物研究与开发,1995;7(4):58-64.
[145]Wang Lei. Luo Shurong. Li guang yi. Determination of four neo2clerodane diterpenoids of Teucirum sp. By HPTLC scanning[J]药学学报,2000;35(4)B:294~296.
[146]蒋忠,李广义.二齿香科科化学成份的研究[J].中国中医杂志,1997;(22):105.
[147]王磊,罗淑宋,李广义.薄层扫描法测定香科属植物中4种新克罗烷型二萜的含量[J].药学学报,2000;35(4)B:294-296
[148]王文燕,张铁军.卡他金石蚕的甲醇及二氯甲烷提取物对心血管系统的作用[J].国外医学.植物药分册,1998;(13)6:273.
[153]雷磊.冬虫夏草与伪品地蚕草石蚕的鉴别[J].武警辽宁省总队医院药剂科.辽宁沈阳。中医药学刊,2001;(18)1:91.
[149]《中药辞海》编审委员会.中药辞海[M].北京:中国医药科技出版社,1993:1948.
[150]国家中医药管理局《中华本草》编委会.中华本草(第7册)[M].上海:上海科学技术出版社,1999:221.
[151]杨中琳,唐登峰,程启厚,胡永美.地蚕不同药用部位的比较研究[J].ITCM,2003;4(20):24.
[152]杨中琳,唐登峰,程启厚,胡永美.地蚕不同药用部位挥发油的气质联析[J].中成药,2002;3(24):205.
[153]雷磊.冬虫夏草与伪品地蚕草石蚕的鉴别[J].武警辽宁省总队医院药剂科.辽宁沈阳。中医药学刊,2001;1(18):91.
[154]张磊,王军花,濮存海.地蚕指纹图谱的初步研究[J].时珍国医国药,2008;11(19):2574.
[155]杨琳,杨志学.地蚕化学成份的预实验[J].中国民族医药杂志,2007;(2):51.