电针结合激光对单纯性肥胖患者内脏脂肪含量影响的临床研究
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摘要
研究背景：
肥胖病是常见的营养障碍性疾病,其根本原因是能量的正平衡。它是由特定的生化因子所引起的一系列进食调控和能量代谢紊乱而导致的疾病,与遗传、环境、膳食结构等多种因素有关,其中基因是主要的决定因素。随着经济的发展,人民生活水平的提高,肥胖发病率的上升幅度令人担忧。近些年采用传统的中医药方法治疗本病取得了显着效果,特别是针灸减肥以其疗效显着,无毒副作用而广泛被患者接受,而其针灸减肥的作用机理也成为目前医学研究热点。近几年来,国内对针灸治疗单纯性肥胖症的临床及作用机理做了大量研究,取得了可喜的成绩。
研究目的：
观察电针结合激光治疗对单纯性肥胖患者内脏脂肪含量的影响,寻找针灸治疗单纯性肥胖的优化方案。
研究方法：
将60例单纯性肥胖患者随机分为电针组、电针结合激光组,并分别给予电针,电针加激光治疗,观察针刺治疗前后患者肥胖指标(腰围、臀围、股围、体重、体重指数、体脂百分比、内脏脂肪含量)的变化,进行统计分析。
研究结果：
经单纯电针治疗、电针结合激光治疗后,两组患者的体重、腰围、臀围、股围、BMI、FAT和VFA均下降,治疗前后比较各项指标差异均有显着性(P<0.01)；两组总有效率分别为90.00%、90.00%；这些均提示单纯电针、电针结合激光都是治疗单纯性肥胖病的有效方法。治疗后两组各指标下降值经两组独立样本T检验比较示电针结合激光组体重、FAT下降值较单纯电针组比较差异具有显着性统计学意义(P<0.05)；腰围及VFA下降值比较差异具有极显着性统计学意义(P<0.01)；BMI、臀围及股围方面两者差异比较无统计学意义；说明电针结合激光减肥疗效在降低内脏脂肪方面优于电针。电针结合激光组的显效率高于单纯电针组,但经统计学分析,差异无统计学意义。
研究结论：
电针、电针结合激光都是单纯性肥胖的有效治疗方法,电针结合激光治疗在降低体重、FAT、腰围、VFA方面优于电针。
Background:
The obesiyt is a kind of common dystrophic disease which basic reason is positive balance of the energy. It is a series of regulation of diet and energy metabolism disorder caused by particular bio-chemical factor. It related to various factors, such as heredity, environment and the meal strurcturc.etc…Among them, the gene is a main decisive factor. With the economic development and improvement of living condition, the rising range of the incidence of obesity is troubling. In recent years the use of traditional Chinese medicine treatment of the disease has achieved significant results, especially acupuncture slimming effect of its significant, non-toxic side effects in patients with widely accepted, and the mechanism of acupuncture slimming of the current medical research have also become hot spots. In recent years, the domestic acupuncture treatment of obesity and simple mechanism to do a lot of research, has made gratifying achievements.
Purpose:
Observe the effect to simple obesity patient's visceral fat quantity by combining electric-acupuncture with laser, find out the better treatment program.
Method:
Sixty simple obesity patients were randomly divided into two groups:lectro-cupuncture roup, electro-acupuncture and laser group. After treatment, obesity index(waistline, hip circumference, thigh circumference, body mass, body mass index, percentage of body fat and fat content of internal organs), and post-treatment were observed.SPSS13.0 software was performed in the statistical analysis.
Result:
After treatment, the body mass, waistline, hip circumference, thigh circumference, BMI, FAT and VFA were all descended(P<0.01). The total effective rate of electro-acupuncture group, electro-acupuncture and laser group were 90.00%,90.00%respectively. These prompted that electr-acupuncture, electro-acupuncture and laser were both the effective treatments on simple obesity. With independent-samples T test, there was statistical significance between electro-acupuncture group and electro-acupuncture with laser group on FAT and bodymass (PO.05). There was remarkably statistical significance between the two group on waistlin and VFA(PO.O1). There was no statistical significance between the two group on BMI, hip circumference, thigh circumference and the total effective rate. All these indicated that electro-acupuncture and laser was better than electro-acupuncture on degrading the visceral fat.
Conclusion:
Both the electro-acupuncture and the electro-acupuncture with laser are effective treatments on simple obesity, the electro-acupuncture with laser group's changes in waist circumference, FAT, bodymass and VFA are obvious than the electro-acupuncture group's.
肥胖病是常见的营养障碍性疾病,其根本原因是能量的正平衡。它是由特定的生化因子所引起的一系列进食调控和能量代谢紊乱而导致的疾病,与遗传、环境、膳食结构等多种因素有关,其中基因是主要的决定因素。随着经济的发展,人民生活水平的提高,肥胖发病率的上升幅度令人担忧。近些年采用传统的中医药方法治疗本病取得了显着效果,特别是针灸减肥以其疗效显着,无毒副作用而广泛被患者接受,而其针灸减肥的作用机理也成为目前医学研究热点。近几年来,国内对针灸治疗单纯性肥胖症的临床及作用机理做了大量研究,取得了可喜的成绩。
研究目的：
观察电针结合激光治疗对单纯性肥胖患者内脏脂肪含量的影响,寻找针灸治疗单纯性肥胖的优化方案。
研究方法：
将60例单纯性肥胖患者随机分为电针组、电针结合激光组,并分别给予电针,电针加激光治疗,观察针刺治疗前后患者肥胖指标(腰围、臀围、股围、体重、体重指数、体脂百分比、内脏脂肪含量)的变化,进行统计分析。
研究结果：
经单纯电针治疗、电针结合激光治疗后,两组患者的体重、腰围、臀围、股围、BMI、FAT和VFA均下降,治疗前后比较各项指标差异均有显着性(P<0.01)；两组总有效率分别为90.00%、90.00%；这些均提示单纯电针、电针结合激光都是治疗单纯性肥胖病的有效方法。治疗后两组各指标下降值经两组独立样本T检验比较示电针结合激光组体重、FAT下降值较单纯电针组比较差异具有显着性统计学意义(P<0.05)；腰围及VFA下降值比较差异具有极显着性统计学意义(P<0.01)；BMI、臀围及股围方面两者差异比较无统计学意义；说明电针结合激光减肥疗效在降低内脏脂肪方面优于电针。电针结合激光组的显效率高于单纯电针组,但经统计学分析,差异无统计学意义。
研究结论：
电针、电针结合激光都是单纯性肥胖的有效治疗方法,电针结合激光治疗在降低体重、FAT、腰围、VFA方面优于电针。
Background:
The obesiyt is a kind of common dystrophic disease which basic reason is positive balance of the energy. It is a series of regulation of diet and energy metabolism disorder caused by particular bio-chemical factor. It related to various factors, such as heredity, environment and the meal strurcturc.etc…Among them, the gene is a main decisive factor. With the economic development and improvement of living condition, the rising range of the incidence of obesity is troubling. In recent years the use of traditional Chinese medicine treatment of the disease has achieved significant results, especially acupuncture slimming effect of its significant, non-toxic side effects in patients with widely accepted, and the mechanism of acupuncture slimming of the current medical research have also become hot spots. In recent years, the domestic acupuncture treatment of obesity and simple mechanism to do a lot of research, has made gratifying achievements.
Purpose:
Observe the effect to simple obesity patient's visceral fat quantity by combining electric-acupuncture with laser, find out the better treatment program.
Method:
Sixty simple obesity patients were randomly divided into two groups:lectro-cupuncture roup, electro-acupuncture and laser group. After treatment, obesity index(waistline, hip circumference, thigh circumference, body mass, body mass index, percentage of body fat and fat content of internal organs), and post-treatment were observed.SPSS13.0 software was performed in the statistical analysis.
Result:
After treatment, the body mass, waistline, hip circumference, thigh circumference, BMI, FAT and VFA were all descended(P<0.01). The total effective rate of electro-acupuncture group, electro-acupuncture and laser group were 90.00%,90.00%respectively. These prompted that electr-acupuncture, electro-acupuncture and laser were both the effective treatments on simple obesity. With independent-samples T test, there was statistical significance between electro-acupuncture group and electro-acupuncture with laser group on FAT and bodymass (PO.05). There was remarkably statistical significance between the two group on waistlin and VFA(PO.O1). There was no statistical significance between the two group on BMI, hip circumference, thigh circumference and the total effective rate. All these indicated that electro-acupuncture and laser was better than electro-acupuncture on degrading the visceral fat.
Conclusion:
Both the electro-acupuncture and the electro-acupuncture with laser are effective treatments on simple obesity, the electro-acupuncture with laser group's changes in waist circumference, FAT, bodymass and VFA are obvious than the electro-acupuncture group's.
引文
[1]张宽智.从肝论治肥胖症[J].北京中医,1994,13(4)：33-34.
[2]林应华.实脾轻身饮治疗单纯性肥胖症的临床研究[J].中国中西医结合脾胃杂志,1999,7(2)：110、111
[3]刘志诚,孙凤岷.肥胖症的针灸治疗[J].现代康复,2001,5(9)：16-17.
[4]李晶,陈筱云,赵莉娟.肥胖病的中医辨证.中国医药学报,2003,18(1)：59,60
[5]孙庆涪,徐有强.肥胖症的中医治疗概况[J].中医杂志,1990,31(5)：53-55.
[6]危北海等.单纯性肥胖症的诊断及疗效评定标准[J].中国中西医结合杂志,1998,18(5)：317-319.
[7]汪受传.中医儿科学[M]北京：中国中医药科技出版社,1999,735-736.
[8]崔鸿峥.单纯性肥胖症的传统康复治疗[J].锦州医学院学报,1996,17(6)：26-27
[9]宋咏梅,宋昌红.肥胖体型者辨证论治规律初探[J].甘肃中医院学报,1997,14(3)：8-9
[10]日本原桃介.肥胖症的汉方治疗[J].国外医学.中医中药分册1994,15(2)：96,97
[11]张淑亭,宋福生,李玉英,等.降脂减肥健美饮治疗高脂肥胖症18例观察[J].河北中医,1994,16(4)：12,13
[12]万力生.剖析儿童单纯性肥胖症的致肥因素及对策[J].天津中医药2003,20(6)15-17.
[13]王玉芬.妇女单纯性肥胖病的中医治疗[J].中国农村医学,1987,5(10)
[14]基础与临床内分泌学Basic and clinical endocrinology世界图书出版社,2001年5月第一版Raneis S, Greenspan.
【15】 BouebardC, Perusse L.Genetic aspects of obesity [J] AmNYAcadSci,1993,699:26-35.
[16]张健,华琦主编.代谢综合症[M].北京：人民卫生出版社,2003：129.
[17]张朝佑.人体解剖学下册2版.北京.北京人民出版社.1998：1264.
【18】KalraSP.Neuron.l997;19:227.
【19】 Amer P.Free fatty acids-do they play a central role in type 2 Diabetes Obes.Metab,2001;3:11.
[20]宁光.脂肪内分泌功能与胰岛素抵抗.中华老年多器官疾病杂志,2005；4(1)：13.
[21]王忠英.精神过度紧张容易导致肥胖.世界新闻报,2004-8-1.
【22】 Bray G Popkin B.Dietary fat intake does affeet obesity[J].Am J Clin Nutr,1998,68:1157-1173.
【23】 Jequier E.Nutrient effeets:Post absorptive interaetions[J]Proc Nutr Soc,1995,54:253-265.
【1245】Suganami L Nishida L Ogawa Y.A paracrine loop between adipocytes and macrophages aggravates inflammatory changes:role of free fatty acids and tumor necrosis factor alpha [J].Arterioscler Thromb VascBiol,2005,25(10):2O62-2068.
【25】NishimuraS, Manabel, Nagasaki M, et al.In vivo imaging in mice reveals local cell dynamics and infl ammation in obese adipose tissue [J].J Clin Invest,2008,118(2):710-721.
[26]王红玉·针刺治疗单纯性肥胖病60例临床疗效观察·针灸临床杂志.2001,17(4)：27,28
[27]沈洁,侯庆.针刺华佗夹脊治疗单纯性肥胖疗效观察[J].上海针灸杂志,2000；(1)：29.
[28]赵喜新,田开宇,王培育.平刺透穴法治疗肥胖症34例[J].中医针灸杂志,2006,26(8)：574
[29]王森,黄根兰,王培艳,等.针刺水穴治疗单纯性肥胖病疗效观察[J].针灸临床杂志,2005,21(10)：41-42
[30]郝重耀,张居元.耳穴贴压磁珠治疗单纯性肥胖症50例[J].山西中医,2004,20(6)：36
[31]Shkaish.双侧耳针刺激对健康志愿者和轻度肥胖患者体重的影响.国外医学中医中药分册,2001,23(2)：115
[32]唐春雨,李思唐.灸疗减肥临床疗效分析[J].针刺研究,1992；17(4)：261.
[33]陈俊鸿,郭佳世.针灸治疗单纯性肥胖症30例[J].中国针灸,1984：(4)：24.
[34]杨涛,欧桂珍.穴位埋线为主治疗单纯性肥胖症60例[J].上海针灸杂志,2003,22(2)：35
[35]植兰英.埋线治疗单纯性肥胖症30例[J].shanghai J Acu-mox, Jun2004,23(6):24
[36]陈怀生.电针结合耳穴贴压治疗单纯性肥胖150例[J].Journal of Qiqihar Medieal College,2008, 29(5):582
【37】 Wozniak P, OszukowskiP, StaehowiakG, et al.The Effectiveness of Low-calorie Dietor Dlet with Acupuncture Treatment in Obese Peri-and post-menopausal[J].WomenGine koiPol,2003, 74(2):102.
[38]赵琛,张旭萍,施茵等.灸补脾胃之主方治疗单纯性肥胖病32例临床观察[J].辽宁中医杂志,2006,33(8)：1016-1017.
[39]林兵宾.腹部电针配合背部走罐为主治疗单纯性肥胖68例[J].Shanghai J Acu-mox,2009, 28(5):28
[40]李明高,李树人.针刺拔罐治疗单纯性肥胖症80例临床观察[J].中国针灸,1991；11(6)：27.
[41]吴军君,王海燕,周启棣.针刺配合刮疹治疗单纯性肥胖108例临床观察[J].中医中药,2006,3(18)：107-108.
[42]刘志诚,孙凤岷,徐斌等.针刺对肥胖大鼠大脑皮质神经信息物质的影响[J].中国临床康复,2004,8(18)：3543-3545
[43]刘志诚,孙风岷,朱苗花等.针刺对肥胖大鼠纹状体作用的研究[J].针刺研究.2001,26(2)：122-126
[44]刘志诚,孙凤岷,朱苗花等.针刺对肥胖大鼠杏仁核作用的研究[J].针剌研究,2000,25(1)：18-21
[45]刘志诚,孙风岷,韩燕等.针刺对肥胖大鼠下丘脑外侧区单胺类递质和ATP酶活性的影响[J].中国中西医结合杂志,2000,20(7)：521-523
[46]刘志诚,孙凤岷,苏静等.针刺对肥胖大鼠腹内侧核作用的研究[J].中医杂志,2000,41(1)：25-26
[47]赵玫,袁锦虹,李嘉等.针刺对实验性肥胖大鼠下丘脑摄食中枢的影响[J].中国针灸,2001,21(5)：305-306
[48]相希,钟莉.神经系统在肥胖和针灸减肥中的作用机理[J].中国针灸,2007,25(2)：396-397
[49]崔蒙.针灸对中枢神经的影响[J].国外医学·中医中药分册,1990,12(4)：1.
[50]刘志诚,孙凤岷,王沂争,等.针刺治疗对单纯性肥胖胃肠实热型患者的良性调整作用探讨[J]. 中国中西医结合杂志,1995,15(3)：137.
[51]刘志诚,孙凤岷,赵东红等.针刺对肥胖大鼠瘦素水平和瘦素受体基因表达的作用[J].中国针灸,2003,23(7)：412-416.
[52]刘志诚,孙凤岷,赵东红等.针刺对肥胖大鼠脂肪组织β-肾上腺素能受体的基因表达的影响[J].中医杂志,2003,44(7)：503-505.
[53]赵银龙.针灸对单纯性肥胖患者糖代谢的影响[J].江西中医药,1992,23(6)：44.
[54]刘志诚,孙凤岷,胡丽梅,等.针灸减肥的临床观察及其降低脂质的研究[J].中国康复,1990,5(3)：110.
[55]王晓燕,李静茁.针刺对单纯性肥胖症患者体表胃电图影响的研究[J].中国美容医学,2006,15(5)：570
[56]李嘉,胡葵.针刺对单纯性肥胖病唾液淀粉酶活性的影响[J].针灸临床杂志,1998,14(11)：48-49
[57]祝之明等.代谢综合征病因探索与临床实践.2005：308-323.
[58]AscasoJF, Romero P, RealJT, etaLAbdominal obesity, insulin resistance, and metabolic syndrome in a southern European population.Eur J Intern Med,2003,14:101-106.
[59]Bjorntorp PAbdominal obesity and the metabolic syndrome.Ann Med,1992,24:465-468.
[60]DespresJP, Lemieux I.Abdominal obesity and metabolic syndrome.Nature,2006,444:881-887.
[61]DespresJP, Lemieux I, Bergeron J, et al.Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk.Arterioscler Thromb Vase Biol,2008,28:1039-1049.
[62]HeHB, ZhaoZG, PuYF, etal. [Relationship of different types of abdominal obesity to risk of metabolic syndromeJ.Zhonghua Yi Xue Za Zhi,2008,88:1251-1254.
[63]Kim HM, Kim DJ, Jung IH, et al.Prevalence of the metabolic syndrome among Korean adults using the new International Diabetes Federation definition and the new abdominal obesity criteria for the Korean people.Diabetes Res ClinPract,2007,77:99-106.
[64]GabrielssonBG, Johansson JM, LonnM, etal.High expression of complement components in omental adipose tissue in obese men.Obes Res,2003,11:699-708.
[65]Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin.Science,2005,307:426-430.
[66]Hayashi T, Boyko EJ, Leonetti DL, et al. Visceral adiposity and the risk of impaired glucose to lerance:a prospective study among Japanese Americans.Diabetes Care,2003,26:650-655.
[67]邵新宇,贾伟平.腹内脂肪与代谢综合征.中华内分泌代谢杂志,2004,3：279-282.
[68]Appel SJ, Jones ED, Kennedy-Malone L.Central obesity and the metabolic syndrome:implications for primary care providers.J Am Acad Nurse Pract,2004,16:335-342.
[69]New criteria for'obesity disease'in Japan.Circ J,2002,66:987-992.
[2]林应华.实脾轻身饮治疗单纯性肥胖症的临床研究[J].中国中西医结合脾胃杂志,1999,7(2)：110、111
[3]刘志诚,孙凤岷.肥胖症的针灸治疗[J].现代康复,2001,5(9)：16-17.
[4]李晶,陈筱云,赵莉娟.肥胖病的中医辨证.中国医药学报,2003,18(1)：59,60
[5]孙庆涪,徐有强.肥胖症的中医治疗概况[J].中医杂志,1990,31(5)：53-55.
[6]危北海等.单纯性肥胖症的诊断及疗效评定标准[J].中国中西医结合杂志,1998,18(5)：317-319.
[7]汪受传.中医儿科学[M]北京：中国中医药科技出版社,1999,735-736.
[8]崔鸿峥.单纯性肥胖症的传统康复治疗[J].锦州医学院学报,1996,17(6)：26-27
[9]宋咏梅,宋昌红.肥胖体型者辨证论治规律初探[J].甘肃中医院学报,1997,14(3)：8-9
[10]日本原桃介.肥胖症的汉方治疗[J].国外医学.中医中药分册1994,15(2)：96,97
[11]张淑亭,宋福生,李玉英,等.降脂减肥健美饮治疗高脂肥胖症18例观察[J].河北中医,1994,16(4)：12,13
[12]万力生.剖析儿童单纯性肥胖症的致肥因素及对策[J].天津中医药2003,20(6)15-17.
[13]王玉芬.妇女单纯性肥胖病的中医治疗[J].中国农村医学,1987,5(10)
[14]基础与临床内分泌学Basic and clinical endocrinology世界图书出版社,2001年5月第一版Raneis S, Greenspan.
【15】 BouebardC, Perusse L.Genetic aspects of obesity [J] AmNYAcadSci,1993,699:26-35.
[16]张健,华琦主编.代谢综合症[M].北京：人民卫生出版社,2003：129.
[17]张朝佑.人体解剖学下册2版.北京.北京人民出版社.1998：1264.
【18】KalraSP.Neuron.l997;19:227.
【19】 Amer P.Free fatty acids-do they play a central role in type 2 Diabetes Obes.Metab,2001;3:11.
[20]宁光.脂肪内分泌功能与胰岛素抵抗.中华老年多器官疾病杂志,2005；4(1)：13.
[21]王忠英.精神过度紧张容易导致肥胖.世界新闻报,2004-8-1.
【22】 Bray G Popkin B.Dietary fat intake does affeet obesity[J].Am J Clin Nutr,1998,68:1157-1173.
【23】 Jequier E.Nutrient effeets:Post absorptive interaetions[J]Proc Nutr Soc,1995,54:253-265.
【1245】Suganami L Nishida L Ogawa Y.A paracrine loop between adipocytes and macrophages aggravates inflammatory changes:role of free fatty acids and tumor necrosis factor alpha [J].Arterioscler Thromb VascBiol,2005,25(10):2O62-2068.
【25】NishimuraS, Manabel, Nagasaki M, et al.In vivo imaging in mice reveals local cell dynamics and infl ammation in obese adipose tissue [J].J Clin Invest,2008,118(2):710-721.
[26]王红玉·针刺治疗单纯性肥胖病60例临床疗效观察·针灸临床杂志.2001,17(4)：27,28
[27]沈洁,侯庆.针刺华佗夹脊治疗单纯性肥胖疗效观察[J].上海针灸杂志,2000；(1)：29.
[28]赵喜新,田开宇,王培育.平刺透穴法治疗肥胖症34例[J].中医针灸杂志,2006,26(8)：574
[29]王森,黄根兰,王培艳,等.针刺水穴治疗单纯性肥胖病疗效观察[J].针灸临床杂志,2005,21(10)：41-42
[30]郝重耀,张居元.耳穴贴压磁珠治疗单纯性肥胖症50例[J].山西中医,2004,20(6)：36
[31]Shkaish.双侧耳针刺激对健康志愿者和轻度肥胖患者体重的影响.国外医学中医中药分册,2001,23(2)：115
[32]唐春雨,李思唐.灸疗减肥临床疗效分析[J].针刺研究,1992；17(4)：261.
[33]陈俊鸿,郭佳世.针灸治疗单纯性肥胖症30例[J].中国针灸,1984：(4)：24.
[34]杨涛,欧桂珍.穴位埋线为主治疗单纯性肥胖症60例[J].上海针灸杂志,2003,22(2)：35
[35]植兰英.埋线治疗单纯性肥胖症30例[J].shanghai J Acu-mox, Jun2004,23(6):24
[36]陈怀生.电针结合耳穴贴压治疗单纯性肥胖150例[J].Journal of Qiqihar Medieal College,2008, 29(5):582
【37】 Wozniak P, OszukowskiP, StaehowiakG, et al.The Effectiveness of Low-calorie Dietor Dlet with Acupuncture Treatment in Obese Peri-and post-menopausal[J].WomenGine koiPol,2003, 74(2):102.
[38]赵琛,张旭萍,施茵等.灸补脾胃之主方治疗单纯性肥胖病32例临床观察[J].辽宁中医杂志,2006,33(8)：1016-1017.
[39]林兵宾.腹部电针配合背部走罐为主治疗单纯性肥胖68例[J].Shanghai J Acu-mox,2009, 28(5):28
[40]李明高,李树人.针刺拔罐治疗单纯性肥胖症80例临床观察[J].中国针灸,1991；11(6)：27.
[41]吴军君,王海燕,周启棣.针刺配合刮疹治疗单纯性肥胖108例临床观察[J].中医中药,2006,3(18)：107-108.
[42]刘志诚,孙凤岷,徐斌等.针刺对肥胖大鼠大脑皮质神经信息物质的影响[J].中国临床康复,2004,8(18)：3543-3545
[43]刘志诚,孙风岷,朱苗花等.针刺对肥胖大鼠纹状体作用的研究[J].针刺研究.2001,26(2)：122-126
[44]刘志诚,孙凤岷,朱苗花等.针刺对肥胖大鼠杏仁核作用的研究[J].针剌研究,2000,25(1)：18-21
[45]刘志诚,孙风岷,韩燕等.针刺对肥胖大鼠下丘脑外侧区单胺类递质和ATP酶活性的影响[J].中国中西医结合杂志,2000,20(7)：521-523
[46]刘志诚,孙凤岷,苏静等.针刺对肥胖大鼠腹内侧核作用的研究[J].中医杂志,2000,41(1)：25-26
[47]赵玫,袁锦虹,李嘉等.针刺对实验性肥胖大鼠下丘脑摄食中枢的影响[J].中国针灸,2001,21(5)：305-306
[48]相希,钟莉.神经系统在肥胖和针灸减肥中的作用机理[J].中国针灸,2007,25(2)：396-397
[49]崔蒙.针灸对中枢神经的影响[J].国外医学·中医中药分册,1990,12(4)：1.
[50]刘志诚,孙凤岷,王沂争,等.针刺治疗对单纯性肥胖胃肠实热型患者的良性调整作用探讨[J]. 中国中西医结合杂志,1995,15(3)：137.
[51]刘志诚,孙凤岷,赵东红等.针刺对肥胖大鼠瘦素水平和瘦素受体基因表达的作用[J].中国针灸,2003,23(7)：412-416.
[52]刘志诚,孙凤岷,赵东红等.针刺对肥胖大鼠脂肪组织β-肾上腺素能受体的基因表达的影响[J].中医杂志,2003,44(7)：503-505.
[53]赵银龙.针灸对单纯性肥胖患者糖代谢的影响[J].江西中医药,1992,23(6)：44.
[54]刘志诚,孙凤岷,胡丽梅,等.针灸减肥的临床观察及其降低脂质的研究[J].中国康复,1990,5(3)：110.
[55]王晓燕,李静茁.针刺对单纯性肥胖症患者体表胃电图影响的研究[J].中国美容医学,2006,15(5)：570
[56]李嘉,胡葵.针刺对单纯性肥胖病唾液淀粉酶活性的影响[J].针灸临床杂志,1998,14(11)：48-49
[57]祝之明等.代谢综合征病因探索与临床实践.2005：308-323.
[58]AscasoJF, Romero P, RealJT, etaLAbdominal obesity, insulin resistance, and metabolic syndrome in a southern European population.Eur J Intern Med,2003,14:101-106.
[59]Bjorntorp PAbdominal obesity and the metabolic syndrome.Ann Med,1992,24:465-468.
[60]DespresJP, Lemieux I.Abdominal obesity and metabolic syndrome.Nature,2006,444:881-887.
[61]DespresJP, Lemieux I, Bergeron J, et al.Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk.Arterioscler Thromb Vase Biol,2008,28:1039-1049.
[62]HeHB, ZhaoZG, PuYF, etal. [Relationship of different types of abdominal obesity to risk of metabolic syndromeJ.Zhonghua Yi Xue Za Zhi,2008,88:1251-1254.
[63]Kim HM, Kim DJ, Jung IH, et al.Prevalence of the metabolic syndrome among Korean adults using the new International Diabetes Federation definition and the new abdominal obesity criteria for the Korean people.Diabetes Res ClinPract,2007,77:99-106.
[64]GabrielssonBG, Johansson JM, LonnM, etal.High expression of complement components in omental adipose tissue in obese men.Obes Res,2003,11:699-708.
[65]Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin.Science,2005,307:426-430.
[66]Hayashi T, Boyko EJ, Leonetti DL, et al. Visceral adiposity and the risk of impaired glucose to lerance:a prospective study among Japanese Americans.Diabetes Care,2003,26:650-655.
[67]邵新宇,贾伟平.腹内脂肪与代谢综合征.中华内分泌代谢杂志,2004,3：279-282.
[68]Appel SJ, Jones ED, Kennedy-Malone L.Central obesity and the metabolic syndrome:implications for primary care providers.J Am Acad Nurse Pract,2004,16:335-342.
[69]New criteria for'obesity disease'in Japan.Circ J,2002,66:987-992.