抚顺城区大气悬浮颗粒物污染及其对小学生肺功能和城市人口部分疾病死亡率影响的研究
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摘要
目的
辽宁省抚顺市是我国北方典型的以工业生产燃煤污染为主的城市之一,为了解抚顺市城区大气颗粒物污染现状及对学龄儿童肺功能和城市人口部分疾病死亡率的影响,结合抚顺市近五年气象、环保监测、城市人口死亡报告等资料,分析室内、外大气及个人暴露颗粒污染物状况(TSP、PM_(10)、PM_(2.5)、PM_(1.0)、PAH_s和NPAH_s等指标)、学龄儿童肺功能改变(FVC、FEV_(1.0)和FEV_(1.0)%等指标)和大气悬浮颗粒物污染对心脑血管疾病、呼吸系统疾病死亡率影响的时序分析研究结果,评价抚顺城市空气质量,为政府改善大气环境决策提供科学依据。
1、根据抚顺市1999～2003年大气监测资料,在重污染区内选距离同一工业污染源不等距离的三所小学为监测点。监测室外大气TSP、PM_(10)、PM_(2.5)、PM_(1.0)浓度和TSP中的粒径构成;分析悬浮颗粒物中PAH_s和NPAH_s含量、来源和所携颗粒物的粒径构成;了解监测点周围居民室内、外及个人暴露环境中空气颗粒污染物浓度特征。
2、了解2002年7月～2003年4月间不同季节三个监测点小学生肺功能的变化。
3、收集抚顺市1999～2003年大气TSP监测资料、气象资料、城市人口死亡报告资料,利用生态学研究方法,采用Poisson回归加局部自动回归统计方法,定量分析TSP浓度对心脑血管疾病、呼吸系统疾病死亡率的影响。
方法
1、监测点的选择
利用抚顺市近五年环保监测、主要污染企业污染物排放量变化资料,在
ObjectivesIn order to learn that status of atmospheric particle pollution, impact on lung functions of children, and TSPs influence to mortality in Fushun, combine meteorological materials, environment monitoring materials and urban population death report materials at the past five years in such city as Fushun, Liaoning China, the research has been carried on also to analysed polluted particles at indoor and outdoor atmosphere and individual expose to pollutant and monitor the state (TSP , PM_(10), PM_(2.5) PM_(1.0), Such indexes as PAHS and NPAHS ,etc. ) , school - agers lung function changes (FVC , FEV_(1.0)and FEV_(1.0)% of the grade indexes ) and the atmospheric TSP pollute the time sequence influenced to mortality of the cardiovascular disease and respiratory disease. Through analyzing the result of study, evaluate the air quality of Fushun, we can offer scientific basis for the fact that the municipal government improves the atmospheric environment and makes policy.1. According to the data of the atmosphere monitoring from the Fushun Environmental Protection Monitoring Station in past five years ( 1999 - 2003) , three primary schools of different distances from the same pollution sources of industrial enterprises in the heavy contaminated area (Wanghua) has been selected as the monitoring sites, which atmospheric PM_(10), PM_(2.5), PM_(1.0) and ones percentage in TSP have been monitored. It is analyzed that much ring of Polycyclic Aromatic Hydrocarbons ( PAHs) and Nitre - Polycyclic Aromatic Hydrocarbon (NPAHS) content, the source and also concentration percentage in TSP, even the health effect. Understand residents indoor, outdoor and individuals expose to
the characteristic of density of particle and pollutant of air in the environment, such as PM10 and PM2 5.2. The pulmonary functions of pupils in the three monitoring primary schools had been measured to determine the change of the index from Jul. 2002 to Apr. 2003.3. Collecting data of 1999 -2003 of Fushun, including the atmospheric TSP concentration, meteorologic data, mortality of everyday and Chinese time calendar, using the ecological principle, Possion Regression and Local Auto -Regression has been implenmented to detect the association between TSP densities and cardiovascular disease & respiratory disease death rate.Methods1. The choice of the monitoring spotsBased on the meteorologic data, environment monitoring data, the emission of main pollutant of enterprise with heavy pollution in nearly five years of Fushun , confirm where the air pollution is light, middle and heavy, we selected three primary schools which are different distances from the same pollution sources in serious contaminated area (No. 3 petrochemical industry, Fushun A-luminum smelters and The special steel group of Fushun, etc. Wanghua south industrial area) on the leeward side of the city throughout the year, namely punctuation mark diameter distance 2,5- 11 km about three primary school respectively at edge object of reference (rail) pursue from pollution sources, i. e. Gaiping, Faku and Guangming, the sampling device was laid in the playground.2. Collection and measure of particle pollutants and hazaous matters in samples(1) The atmospheric particulate samplesSampling happened in every season, keep 2 weeks on each time ( change strain membrane every 2 days, amounts to 7 times) , SIBATA AN - 200 automatic air sampling devices (Japan) , on the flow of 28. 3L/min have been e-quipped with 3 points, which are gathered in succession in 14 days at the same time. Use HOBO ONSET RH TEMP warm hygrometer to measure the tempera-
ture, relative humidity and pressure of atmospheric at the same time. Sample the detailed record of the course at the unified list.(2) The atmospheric particulates density (PM10, PM25) of indoor, outdoor and individual exposesSelect 10 adults, not to smoke and even there are no smoker in home, within 1000M2 around of 3 monitoring schools, age at 40 -60 years old, living more than 3 years in here, the half of them is male and another half is female, who has no expose to material of studying in job, and no plumary diseases previously. The total number is 30 peoples. Individuals sampling device was carrying in 24 hours. When sleeping, put the sampling device in a sound insulation case and keep the sampler on working in succession. At the same time, on outdoor and indoor of the room, one of each MP - X300 sampling devices have been e-quipped, on the same flow, changing membrane once regularly every day, every cycle is 7 days, at heating issue (January ) and no - heating issue ( June ) respectively. The measured temperature, relative humidity of environment should be written down at the same time.(3 ) Measuring of atmospheric particlesUsing fibre membrane of vary aperture ( divide into 9 ) , we had collected suspended particulate in air. Then put them in refrigerate after being sealed with the aluminum foil. Each time gather membranes were equilibrium in the constant temperature, permanent humidity in the weighs room ( Institute of Environmental Science of Japan) , then weigh with the accurate electronic balance of UMT2 (METTER SYSTEM ) , record the weight of the membrane before and after sampling.(4) Measure and analysis the content of PAHS and NPAHS in the particlesPAHS, NPAHS samples has been adopted with huge flow sections dust sampling device, ( SIBATA AH600) , one time every season , flow 566L/MIN, 4 times each cycle, the strain membrane was changed over48h. . After each period of season, the filter should be cleaning by ultrasonic. All samples were took to Japanese Kenzawa University for detecting of 9 kinds PAHS, by high - pressure liquid phase chromatogram /fluorescence detector ( HPLC/FLD) for and with the high - pressure liquid phase chromatogram / chemistry detector
(HPLC/CLP) for 12 kinds of NPAHS.3. Survey of pupil & lung functionHealthy children of 8 - 10 year - old (3 grade pupil) , total 1060, living within lkm vicinity to the school for 3 years at least, were selected as the subjects for lung function checking (about 100 pupils for each school). The inspection phase is divided in four times of namely no - heating issue (July) , heating issue ago ( October) , heating issue ( December) and heating after issue (A-pril). Special Chest HI -701 advanced spirometer (Japan) had been used. The major indicators are: Forced vital capacity (FVC) , Forced expiratory volume in the one second (FEV, 0) , and the rate of one second (FEV, 0/ FVC) , etc.4. The data TSP pollution and mortalityCollect TSP polluting data of atmospheric monitoring points from 1999 to 2003 of the city then calculate the average density monthly (mg/m3). Get such meteorologic materials as the temperature, atmospheric pressure, relative humidity and wind - force of wind direction, etc. Be offered the reported mortality data by Fushun Centre of Diseases Control and prevention, which have be drawn of the cardiovascular disease, respiratory disease case and divided into groups " during the five years.5. Statistical analysisThe data of air particles and harmful substance (TSP, PM10, PM2 5, PM, 0, PAHS and NPAHS index) , together with children's lung function determine data had been input EPI 6.0 databases. SPSS 10.0 software was used for such statistical analysis as significance inspection, analyzing relevant, etc.Time sequence data were inputed in databases with EXCEL. Data processing had been done by SAS software. Describes analyzing of the time distributed of TSP density, mortality of the cardiovascular disease and the respiratory disease were done by S -PLUS software. First, and divide into 6 groups according to the age, sex, the item of time was introduced, and then add the meteorological condition, and carry on local regression at each parts, make the model accord with AIC ( Akaikes Information Criterion) , lead TSP into finally, and analyse TSP density changes associate with the impact on cardiovascular disease,
respiratory disease death rate by automatically with POSSION.Results1. The concentration of suspended particles in atmosphereThe TSP concentrations of Gainping, Faku, Guangming in Winter and Spring are 290. 9|xg/m\280. 4jxg/m3;308. 5|xg/m\285. 4|xg/m3;256. 3jxg/ m3 ,300. 3|jLg/m and have be the 1. 28 ~ 1. 54 times of the Standard of China. All PM10are from 107. 7 to 221. 6|xg/m3 exceed 1. 07 -2. 22 times to the standard. The concentration of PM2 5is between 57. 6fig/m3 and 113. 7jxg/m3, it exceeds American EPA PM2 5 air quality standard 3. 84 -7.76 times. During periods of no heating, the concentration of suspend particle in the air have no significant difference between sites. During periods of heating, the concentration of PM2 5 and PM10 in Guangming is the lowest in the all measure spots. Its values separately are 190. 2|xg/m3 ( PM10 ), 104. 3|jLg/m3 ( PM2 5 ) , 78. 4jxg/m3 (PM, 0) , in the same school, the concentration of particle in winter is more than that in summer, such as PM2 5 and PM, 0 are the most remarkable, PM2 5 concentration of Gaiping is 113. 7jxg/m in winter and 79. 5jxg/m in summer, PM2 5 concentration of Guangming is 104. 3jxg/m in winter and 65. 7p^g/m in summer. The concentrations of PM2 5 and PM, 0 in winter are 1. 53 ~ 1. 75 and 1. 43 ~ 1. 72 times than them at summer.2. The content of PAHS and NPAHS in the particlesThe content of PAHS are dozens of times than the content of NPAHS of atmosphere suspended particles from three primary schools. The PAHS density (total is 2094. OOpmol/m ) of components in winter is 1. 72 ~ 3. 71 times in summer (total is 784.94 pmol/m ) , but the difference is not significant in the summer and winter for total NPAHS density.Through analysis of the composition, the Chr ( Chrysene) , Flu ( Fluoran-thene) , Pyr (Pyrene) and BaA [Benzo Anthracene] , which have 4 Benzo cycles, are higher density in the 9 PAHS be measured in winter, (are 246. 5 pmol/m3,5101 pmol/m3;483. 3 pmol/m3,232. 9 pmol/m3);the 2 - NF (2 -Nitrofluozene) , 2 NP (2 - Nitropyrene) and 6 NC (1 - Nitropyrene) are the
higher ones in 12 kind NPAHS, which are 21. 00 pmol/m3 v4. 97 pmol/m\4.47 pmol/m . The distribution rule of different season are similar in some of NPAHS and PAHS, heating period (December) most high with 2NF, with most high 2NP are on no - heating period (July) , it separate is dozens to thousands of times to other pollutants which be examined.The content of PAHS and NPAHS in air pollution suspended particulate, which under <2. ljxm are 67. 23% and 79. 73% , and which between 2.1 -7. 0 fxm are 25.78% and 12. 67% , and one s >7pjn are 6.99% and 7.6%.3. The content of PM10, PM2 5in indoor, outdoor and individual expose Indoor PM2 5 density in winter is Gaiping 111.7|xg/m3, Faku 147. 4 jxg/m3, Guangmingl32. l|i,g/m3. Not only winter indoor air pollution is higher than summer notably, but also the indoor and outdoor density are very nearly the same. The content of PM2 5 in indoor and outdoor of summer is 103. 8, 99. 4, 100. 1 }JLg/m . Indoor PM2 5 and outdoor density present the positive correlation relation, and the intensity is bigger in winter. The correlation equation is y =0. 529x + 91. 017, the coefficient correlation is R =0. 1551. The density of PM2 5 people sucking have no significance with occupying the indoor and outdoor density at difference sites.Gaiping, Fushun PM]0 individual sucking density is lower than outdoors to expose (P <0.05). Other places have not demonstrated the difference between the density of individual exposes and the indoor and/or outdoor.4. Pupil' s lung functionLung functionality index of pupil in Gaiping ,as FVCNFEVj 0 are(2. 54 ± 0.44 ,1.92 ±0.30) in winter and (2.46 ±0.38 ,1.90 ±0.31 ) in spring.Lung functionality index of pupil in Faku ,as FVC^FEV, 0 are(2. 21 ±0. 39,1.82 ±0.32) in winter and (2. 36 ±0.40 ,2. 02 ±0. 34)in spring.Lung functionality index of pupil in Guangming ,as FVC^FEV,0 are(2.25 ±0.36 ,1.88 ±0.33 ) in winter and (2. 36 ±0. 34 ,2.02 ±0.40 ) in spring.After through a heating period, function index FVC, FEV\ 0 and FEVK 0% of children receives some impact with the heating air pollution in winter maybe. FEV, 0% obviously dropped in winter, then rebounding again after the beginning of Spring. The Gaiping (primary school) students'FVC, FEV, 0 value at which
more close to the industrial pollution sources does not increase but dropped instead in Spring after a heating cycle. Gaiping femals kept in low level of PEFN EFE50^EFE75 comparing with the others, even no -growth or less.5. Results of the evaluation for the association between atmospheric TSP and the mortality of cardiovascular and cerebro - deaths, respiratory? TSP and 4 - days lag TSP density increases per 50jxg/m3 each time, the total group and especially mans every group mortality with cardiovascular and cerebro - deaths had a significant positive correlation, with the increase of TSP, the excess mortality of the cardiovascular and cerebro - deaths increases by 1. 542% , 2. 24% , 0. 826% , 1. 627% and 1. 665% respectively, increase of corresponding different time TSP, the daily mortality of old man's group increased 0. 698% and 0. 038% more. The TSP density increases 50 jmg/m3 of lag behind for 4 days, OR of influenced to the respiratory mortality of total group is 1. 02195 (95% CI = 1. 00195 - 1. 04245). Namely with the increase of TSP density, the excess mortality of respiratory is 2. 195%.Conclusions1. The pollution of air suspend particle is serious in Fushun.The PM10and PM2 5 which injure to human body are more serious matter which have not been reported before, are exceeds Chinas national standard and U.S.A. EPA standard separately by 1. 07 - 2. 22 times and 3. 84 - 7. 76 times. The fire coal gets warm to make pollution aggravate in winter. The fine particles (PM2.5, PM1.0) are higher proportion in TSP. The PM10, PM2.5 and PM, 0 have appeared the trend that nearly pollutant density increases of distance only in winter. Therefore, the coal burning and the meteorological factors make the particles pollution aggravated in winter of Fushun. To improve the process of industrial producing and coal — fired equipments of central heating, and advance the smoke and dust discharge craft, and reduce emission of the particulate matter of tiny diameter, the tasks are extremely urgent.2. The concentration of hazards substance in the particles measuring is relatively higher in the atmosphere of Fushun.
PAHS and NPAHsare absorbed in particles reducing with a grain of increase of diameter gradually. PAHS and NPAHS is almost absorbed in ( <2.1 jxm) particle. The content of PAHsshow that is low in winter and high in summer, and NPAHS is not difference in summer or winter. In summer, the nearer is the distance to industrial pollution sources , the higher are the content of PAHS and NPAHS. We believe that the main source of the particles should be the factories in summer. As there is not this law in winter, but the concentration is relatively high, we can think it is the mainly source that residents dispersing type of coal burning to get warm and cooking.3. The pollution of PM2. 5 in indoor air of Fushun is serious.PM2 5 is 100% over the EPA standard of U. S. A. , The pollution became worsen in winter. The content of PM2.5, PM1.0 in indoors is positive correlation with that in outdoors. PM25of inbreathe by Individual exposes showed no significant difference with that of indoor and outdoor. We believe the monitoring value in outside and indoor can represent level of individual actual expose to pollution.4. Some indexes of pupils lung function in Fushun became worse to some extent after winter. It shows that air particle pollution influences to growth of pupil s lung function in winter.5. Results show that change of urban TSP pollute of 1999 ~ 2003 have effect on the mortality of cardiovascular and cerebro - deaths, respiratory deaths in Fushun.With TSP and 4 - days lag TSP density increases 50jxg/m each time, total group and male vs mortality of cardiovascular and cerebro - deaths and total crowd group respirator}7 excess death rate have increased.
辽宁省抚顺市是我国北方典型的以工业生产燃煤污染为主的城市之一,为了解抚顺市城区大气颗粒物污染现状及对学龄儿童肺功能和城市人口部分疾病死亡率的影响,结合抚顺市近五年气象、环保监测、城市人口死亡报告等资料,分析室内、外大气及个人暴露颗粒污染物状况(TSP、PM_(10)、PM_(2.5)、PM_(1.0)、PAH_s和NPAH_s等指标)、学龄儿童肺功能改变(FVC、FEV_(1.0)和FEV_(1.0)%等指标)和大气悬浮颗粒物污染对心脑血管疾病、呼吸系统疾病死亡率影响的时序分析研究结果,评价抚顺城市空气质量,为政府改善大气环境决策提供科学依据。
1、根据抚顺市1999～2003年大气监测资料,在重污染区内选距离同一工业污染源不等距离的三所小学为监测点。监测室外大气TSP、PM_(10)、PM_(2.5)、PM_(1.0)浓度和TSP中的粒径构成;分析悬浮颗粒物中PAH_s和NPAH_s含量、来源和所携颗粒物的粒径构成;了解监测点周围居民室内、外及个人暴露环境中空气颗粒污染物浓度特征。
2、了解2002年7月～2003年4月间不同季节三个监测点小学生肺功能的变化。
3、收集抚顺市1999～2003年大气TSP监测资料、气象资料、城市人口死亡报告资料,利用生态学研究方法,采用Poisson回归加局部自动回归统计方法,定量分析TSP浓度对心脑血管疾病、呼吸系统疾病死亡率的影响。
方法
1、监测点的选择
利用抚顺市近五年环保监测、主要污染企业污染物排放量变化资料,在
ObjectivesIn order to learn that status of atmospheric particle pollution, impact on lung functions of children, and TSPs influence to mortality in Fushun, combine meteorological materials, environment monitoring materials and urban population death report materials at the past five years in such city as Fushun, Liaoning China, the research has been carried on also to analysed polluted particles at indoor and outdoor atmosphere and individual expose to pollutant and monitor the state (TSP , PM_(10), PM_(2.5) PM_(1.0), Such indexes as PAHS and NPAHS ,etc. ) , school - agers lung function changes (FVC , FEV_(1.0)and FEV_(1.0)% of the grade indexes ) and the atmospheric TSP pollute the time sequence influenced to mortality of the cardiovascular disease and respiratory disease. Through analyzing the result of study, evaluate the air quality of Fushun, we can offer scientific basis for the fact that the municipal government improves the atmospheric environment and makes policy.1. According to the data of the atmosphere monitoring from the Fushun Environmental Protection Monitoring Station in past five years ( 1999 - 2003) , three primary schools of different distances from the same pollution sources of industrial enterprises in the heavy contaminated area (Wanghua) has been selected as the monitoring sites, which atmospheric PM_(10), PM_(2.5), PM_(1.0) and ones percentage in TSP have been monitored. It is analyzed that much ring of Polycyclic Aromatic Hydrocarbons ( PAHs) and Nitre - Polycyclic Aromatic Hydrocarbon (NPAHS) content, the source and also concentration percentage in TSP, even the health effect. Understand residents indoor, outdoor and individuals expose to
the characteristic of density of particle and pollutant of air in the environment, such as PM10 and PM2 5.2. The pulmonary functions of pupils in the three monitoring primary schools had been measured to determine the change of the index from Jul. 2002 to Apr. 2003.3. Collecting data of 1999 -2003 of Fushun, including the atmospheric TSP concentration, meteorologic data, mortality of everyday and Chinese time calendar, using the ecological principle, Possion Regression and Local Auto -Regression has been implenmented to detect the association between TSP densities and cardiovascular disease & respiratory disease death rate.Methods1. The choice of the monitoring spotsBased on the meteorologic data, environment monitoring data, the emission of main pollutant of enterprise with heavy pollution in nearly five years of Fushun , confirm where the air pollution is light, middle and heavy, we selected three primary schools which are different distances from the same pollution sources in serious contaminated area (No. 3 petrochemical industry, Fushun A-luminum smelters and The special steel group of Fushun, etc. Wanghua south industrial area) on the leeward side of the city throughout the year, namely punctuation mark diameter distance 2,5- 11 km about three primary school respectively at edge object of reference (rail) pursue from pollution sources, i. e. Gaiping, Faku and Guangming, the sampling device was laid in the playground.2. Collection and measure of particle pollutants and hazaous matters in samples(1) The atmospheric particulate samplesSampling happened in every season, keep 2 weeks on each time ( change strain membrane every 2 days, amounts to 7 times) , SIBATA AN - 200 automatic air sampling devices (Japan) , on the flow of 28. 3L/min have been e-quipped with 3 points, which are gathered in succession in 14 days at the same time. Use HOBO ONSET RH TEMP warm hygrometer to measure the tempera-
ture, relative humidity and pressure of atmospheric at the same time. Sample the detailed record of the course at the unified list.(2) The atmospheric particulates density (PM10, PM25) of indoor, outdoor and individual exposesSelect 10 adults, not to smoke and even there are no smoker in home, within 1000M2 around of 3 monitoring schools, age at 40 -60 years old, living more than 3 years in here, the half of them is male and another half is female, who has no expose to material of studying in job, and no plumary diseases previously. The total number is 30 peoples. Individuals sampling device was carrying in 24 hours. When sleeping, put the sampling device in a sound insulation case and keep the sampler on working in succession. At the same time, on outdoor and indoor of the room, one of each MP - X300 sampling devices have been e-quipped, on the same flow, changing membrane once regularly every day, every cycle is 7 days, at heating issue (January ) and no - heating issue ( June ) respectively. The measured temperature, relative humidity of environment should be written down at the same time.(3 ) Measuring of atmospheric particlesUsing fibre membrane of vary aperture ( divide into 9 ) , we had collected suspended particulate in air. Then put them in refrigerate after being sealed with the aluminum foil. Each time gather membranes were equilibrium in the constant temperature, permanent humidity in the weighs room ( Institute of Environmental Science of Japan) , then weigh with the accurate electronic balance of UMT2 (METTER SYSTEM ) , record the weight of the membrane before and after sampling.(4) Measure and analysis the content of PAHS and NPAHS in the particlesPAHS, NPAHS samples has been adopted with huge flow sections dust sampling device, ( SIBATA AH600) , one time every season , flow 566L/MIN, 4 times each cycle, the strain membrane was changed over48h. . After each period of season, the filter should be cleaning by ultrasonic. All samples were took to Japanese Kenzawa University for detecting of 9 kinds PAHS, by high - pressure liquid phase chromatogram /fluorescence detector ( HPLC/FLD) for and with the high - pressure liquid phase chromatogram / chemistry detector
(HPLC/CLP) for 12 kinds of NPAHS.3. Survey of pupil & lung functionHealthy children of 8 - 10 year - old (3 grade pupil) , total 1060, living within lkm vicinity to the school for 3 years at least, were selected as the subjects for lung function checking (about 100 pupils for each school). The inspection phase is divided in four times of namely no - heating issue (July) , heating issue ago ( October) , heating issue ( December) and heating after issue (A-pril). Special Chest HI -701 advanced spirometer (Japan) had been used. The major indicators are: Forced vital capacity (FVC) , Forced expiratory volume in the one second (FEV, 0) , and the rate of one second (FEV, 0/ FVC) , etc.4. The data TSP pollution and mortalityCollect TSP polluting data of atmospheric monitoring points from 1999 to 2003 of the city then calculate the average density monthly (mg/m3). Get such meteorologic materials as the temperature, atmospheric pressure, relative humidity and wind - force of wind direction, etc. Be offered the reported mortality data by Fushun Centre of Diseases Control and prevention, which have be drawn of the cardiovascular disease, respiratory disease case and divided into groups " during the five years.5. Statistical analysisThe data of air particles and harmful substance (TSP, PM10, PM2 5, PM, 0, PAHS and NPAHS index) , together with children's lung function determine data had been input EPI 6.0 databases. SPSS 10.0 software was used for such statistical analysis as significance inspection, analyzing relevant, etc.Time sequence data were inputed in databases with EXCEL. Data processing had been done by SAS software. Describes analyzing of the time distributed of TSP density, mortality of the cardiovascular disease and the respiratory disease were done by S -PLUS software. First, and divide into 6 groups according to the age, sex, the item of time was introduced, and then add the meteorological condition, and carry on local regression at each parts, make the model accord with AIC ( Akaikes Information Criterion) , lead TSP into finally, and analyse TSP density changes associate with the impact on cardiovascular disease,
respiratory disease death rate by automatically with POSSION.Results1. The concentration of suspended particles in atmosphereThe TSP concentrations of Gainping, Faku, Guangming in Winter and Spring are 290. 9|xg/m\280. 4jxg/m3;308. 5|xg/m\285. 4|xg/m3;256. 3jxg/ m3 ,300. 3|jLg/m and have be the 1. 28 ~ 1. 54 times of the Standard of China. All PM10are from 107. 7 to 221. 6|xg/m3 exceed 1. 07 -2. 22 times to the standard. The concentration of PM2 5is between 57. 6fig/m3 and 113. 7jxg/m3, it exceeds American EPA PM2 5 air quality standard 3. 84 -7.76 times. During periods of no heating, the concentration of suspend particle in the air have no significant difference between sites. During periods of heating, the concentration of PM2 5 and PM10 in Guangming is the lowest in the all measure spots. Its values separately are 190. 2|xg/m3 ( PM10 ), 104. 3|jLg/m3 ( PM2 5 ) , 78. 4jxg/m3 (PM, 0) , in the same school, the concentration of particle in winter is more than that in summer, such as PM2 5 and PM, 0 are the most remarkable, PM2 5 concentration of Gaiping is 113. 7jxg/m in winter and 79. 5jxg/m in summer, PM2 5 concentration of Guangming is 104. 3jxg/m in winter and 65. 7p^g/m in summer. The concentrations of PM2 5 and PM, 0 in winter are 1. 53 ~ 1. 75 and 1. 43 ~ 1. 72 times than them at summer.2. The content of PAHS and NPAHS in the particlesThe content of PAHS are dozens of times than the content of NPAHS of atmosphere suspended particles from three primary schools. The PAHS density (total is 2094. OOpmol/m ) of components in winter is 1. 72 ~ 3. 71 times in summer (total is 784.94 pmol/m ) , but the difference is not significant in the summer and winter for total NPAHS density.Through analysis of the composition, the Chr ( Chrysene) , Flu ( Fluoran-thene) , Pyr (Pyrene) and BaA [Benzo Anthracene] , which have 4 Benzo cycles, are higher density in the 9 PAHS be measured in winter, (are 246. 5 pmol/m3,5101 pmol/m3;483. 3 pmol/m3,232. 9 pmol/m3);the 2 - NF (2 -Nitrofluozene) , 2 NP (2 - Nitropyrene) and 6 NC (1 - Nitropyrene) are the
higher ones in 12 kind NPAHS, which are 21. 00 pmol/m3 v4. 97 pmol/m\4.47 pmol/m . The distribution rule of different season are similar in some of NPAHS and PAHS, heating period (December) most high with 2NF, with most high 2NP are on no - heating period (July) , it separate is dozens to thousands of times to other pollutants which be examined.The content of PAHS and NPAHS in air pollution suspended particulate, which under <2. ljxm are 67. 23% and 79. 73% , and which between 2.1 -7. 0 fxm are 25.78% and 12. 67% , and one s >7pjn are 6.99% and 7.6%.3. The content of PM10, PM2 5in indoor, outdoor and individual expose Indoor PM2 5 density in winter is Gaiping 111.7|xg/m3, Faku 147. 4 jxg/m3, Guangmingl32. l|i,g/m3. Not only winter indoor air pollution is higher than summer notably, but also the indoor and outdoor density are very nearly the same. The content of PM2 5 in indoor and outdoor of summer is 103. 8, 99. 4, 100. 1 }JLg/m . Indoor PM2 5 and outdoor density present the positive correlation relation, and the intensity is bigger in winter. The correlation equation is y =0. 529x + 91. 017, the coefficient correlation is R =0. 1551. The density of PM2 5 people sucking have no significance with occupying the indoor and outdoor density at difference sites.Gaiping, Fushun PM]0 individual sucking density is lower than outdoors to expose (P <0.05). Other places have not demonstrated the difference between the density of individual exposes and the indoor and/or outdoor.4. Pupil' s lung functionLung functionality index of pupil in Gaiping ,as FVCNFEVj 0 are(2. 54 ± 0.44 ,1.92 ±0.30) in winter and (2.46 ±0.38 ,1.90 ±0.31 ) in spring.Lung functionality index of pupil in Faku ,as FVC^FEV, 0 are(2. 21 ±0. 39,1.82 ±0.32) in winter and (2. 36 ±0.40 ,2. 02 ±0. 34)in spring.Lung functionality index of pupil in Guangming ,as FVC^FEV,0 are(2.25 ±0.36 ,1.88 ±0.33 ) in winter and (2. 36 ±0. 34 ,2.02 ±0.40 ) in spring.After through a heating period, function index FVC, FEV\ 0 and FEVK 0% of children receives some impact with the heating air pollution in winter maybe. FEV, 0% obviously dropped in winter, then rebounding again after the beginning of Spring. The Gaiping (primary school) students'FVC, FEV, 0 value at which
more close to the industrial pollution sources does not increase but dropped instead in Spring after a heating cycle. Gaiping femals kept in low level of PEFN EFE50^EFE75 comparing with the others, even no -growth or less.5. Results of the evaluation for the association between atmospheric TSP and the mortality of cardiovascular and cerebro - deaths, respiratory? TSP and 4 - days lag TSP density increases per 50jxg/m3 each time, the total group and especially mans every group mortality with cardiovascular and cerebro - deaths had a significant positive correlation, with the increase of TSP, the excess mortality of the cardiovascular and cerebro - deaths increases by 1. 542% , 2. 24% , 0. 826% , 1. 627% and 1. 665% respectively, increase of corresponding different time TSP, the daily mortality of old man's group increased 0. 698% and 0. 038% more. The TSP density increases 50 jmg/m3 of lag behind for 4 days, OR of influenced to the respiratory mortality of total group is 1. 02195 (95% CI = 1. 00195 - 1. 04245). Namely with the increase of TSP density, the excess mortality of respiratory is 2. 195%.Conclusions1. The pollution of air suspend particle is serious in Fushun.The PM10and PM2 5 which injure to human body are more serious matter which have not been reported before, are exceeds Chinas national standard and U.S.A. EPA standard separately by 1. 07 - 2. 22 times and 3. 84 - 7. 76 times. The fire coal gets warm to make pollution aggravate in winter. The fine particles (PM2.5, PM1.0) are higher proportion in TSP. The PM10, PM2.5 and PM, 0 have appeared the trend that nearly pollutant density increases of distance only in winter. Therefore, the coal burning and the meteorological factors make the particles pollution aggravated in winter of Fushun. To improve the process of industrial producing and coal — fired equipments of central heating, and advance the smoke and dust discharge craft, and reduce emission of the particulate matter of tiny diameter, the tasks are extremely urgent.2. The concentration of hazards substance in the particles measuring is relatively higher in the atmosphere of Fushun.
PAHS and NPAHsare absorbed in particles reducing with a grain of increase of diameter gradually. PAHS and NPAHS is almost absorbed in ( <2.1 jxm) particle. The content of PAHsshow that is low in winter and high in summer, and NPAHS is not difference in summer or winter. In summer, the nearer is the distance to industrial pollution sources , the higher are the content of PAHS and NPAHS. We believe that the main source of the particles should be the factories in summer. As there is not this law in winter, but the concentration is relatively high, we can think it is the mainly source that residents dispersing type of coal burning to get warm and cooking.3. The pollution of PM2. 5 in indoor air of Fushun is serious.PM2 5 is 100% over the EPA standard of U. S. A. , The pollution became worsen in winter. The content of PM2.5, PM1.0 in indoors is positive correlation with that in outdoors. PM25of inbreathe by Individual exposes showed no significant difference with that of indoor and outdoor. We believe the monitoring value in outside and indoor can represent level of individual actual expose to pollution.4. Some indexes of pupils lung function in Fushun became worse to some extent after winter. It shows that air particle pollution influences to growth of pupil s lung function in winter.5. Results show that change of urban TSP pollute of 1999 ~ 2003 have effect on the mortality of cardiovascular and cerebro - deaths, respiratory deaths in Fushun.With TSP and 4 - days lag TSP density increases 50jxg/m each time, total group and male vs mortality of cardiovascular and cerebro - deaths and total crowd group respirator}7 excess death rate have increased.
引文
1.郭蕾,金银龙.大气污染及对人体健康的影响.卫生与研究,2003,32(5):284-286
2. Ning Tang, Toriba Akird, Kizu Ryoichi, et al. Comparison of atmospheric polycyclic aromatic hydrocarbons and nitropolycylic aromatic hydrocarbons in cities of east. Asia Journal of Ecotechnology Research, 2002, 8(2): 14
3. US EPA office of Air and Radiation, Office of air quality planning and standards fact sheet-EPA's recommended final ozone and particulate matters standards, 1997
4.徐肇翊,金福杰.辽宁城市大气污染造成的居民健康损失及其货币化估计.环境与健康杂志,2003,20(2):67-71
5.刘润香,李鼎.抚顺市大气污染治理成本浅析.辽宁城乡环境科技,2003,23(1):8-10
6.王玮,汤大钢,刘红杰,等.中国PM_(2. 5)污染状况和污染特征的研究.环境科学研究.2000,13(1):1-5
7. Gunter O. Pulmonary effects of inhaled ultrafine particles.(Review)Int Arch Occup Environ Health, 2001, 74: 1-8
8.孙宪民,孙贵范,田村宪治,等.沈阳市大气悬浮颗粒物及PAHS、NPAHS分析.中国公共卫生,2003,19(7):800-802
9. Hayakawa K, Kawaguchi Y, Murahashi T, et al., Distributions of nitropyrenes and mutagenicity in airborne particulates collected with an Andersen sampler, Mutation Res 1995, 348: 57-61
10.武辉,房靖华,钱志强.太原市大气悬颗粒物上多环芳烃的测量与分布研究.中国环境监测,2002,18(4):17-21
11.冯沈迎,高春梅,仝青,等.不同粒径空气颗粒物中11种多环芳烃的分析测定.中国环境监测,2001,17(4):34-37
12.黄业茹,狄一安,施钧慧,等.北京、东京、筑波大气中有机污染物组成研究.环境科学研究,2001,14(1):4-8
13.黄翠玲,徐文箐,赵国栋,等.北京市大气颗粒物中多环芳烃的组成.环境科学,2001,22(4):16-20
14.魏复盛,胡伟,腾恩江,等.空气污染与儿童呼吸系统患病率的相关分析.中国环境科学,2000,20(3):220-224
15.孙强,赵丽,孙德岭,等.我国城市机动车尾气污染防治策略.环境保护,1999,11(2):43-45
16.冯滨,陈能坚.广州市移动源现状及其污染控制管理对策.环境科学研究,1999,12(6):21-24
17.谢绍东,张远航,唐孝炎,等.我国城市地区机动车污染现状与趋势.环境科学研究,2000,13(4):23-25
18.孙宪民.沈阳市大气颗粒物污染现状及对儿童肺功能的影响.博士论文,2003
19. Westerholm R, Li H. A multi-variate statistical analysis of fuel-related polycyclic aromatic hydrocarbone emission from heavy-duty diesel vehicles. Environ Sci Technol, 1994, 28(3): 965-72
20.徐利中,松下秀鹤.空气中多环芳烃的研究现状.环境科学进展,1997,5(5):18-29
21. Durlak SK, Bisowas P, Characterization of polycyclic aromatic hydrocarbones particulate and gaseouse emission from polystyrene combustion. Environ Sci Technol, 1998, 32: 2301-07
22.祈士华.澳门大气气溶胶中多环芳烃研究.环境科学学报,2000,13(4):6-9
23. Khalili NR, Scheff PA, Holssen TM, et al., PAH source fingerprints of cook ovens, diesel and gasline engine heavy trucks and wood combusion emissions. Atmospheric Environment, 1995, 29: 533-42
24.袁彦华,孙连军,郭秀兰,等.多环芳烃化合物毒理学研究.中国公共卫生,1999,15(8):675-76
25.杨文敏,吴丙耀,乌亚萍,等.大气颗粒物提取物的致突变性.中国公共卫生学报,1994,13(20):119-121
26.孙成均,田边(氵絜),小谷野道子,等,空气悬浮颗粒物中硝基多环芳烃多环芳烃化合物粒径分布的研究.现代预防医学,1994,21(3):129-132
27. George T. Wolff. Measurement of Hazards in Particles at a Rural Site on Atlantic Coast, for the Presentation to the 78th Anounce Meeting of Air Pol lution Control Association. 1985, 6, 1621
28. Greenborg A, PAH in New Jersy: A comparion of winter and summer concentration over a two-year period. Atmos Environ, 1998, 19(8): 1325-1339
29.姚渭溪.电厂燃煤锅排放烟尘和多环芳烃的分布及突变特征.环境科学,1993,53(15):3486-92
30.张文丽,徐东群,崔九思,等.空气细颗粒物污染特征及毒性机制的研究进展.中国环境监测,2002,18(1):59-63
31.阚海东,陈秉衡.我国部分城市大气污染对健康影响的研究十年回顾.中国预防医学杂志,2002,36(10):59-61
32.井立滨,秦怡,徐肇翊.本溪市大气污染对慢性呼吸系统疾病的关系.环境与健康杂志,2000,17(5):268-70
33.刘文影,董胜章.机动车尾气慢性毒性效应的研究进展.环境与健康杂志,2002,19(5):413-15
34.夏慧丽,倪小明,陈孟林,等.大气中多环芳烃的研究现状与展望.广西师范大学学报(自然科学版),2003,21(2):67-70
35.完莉莉,汪玉庭.室内空气有机污染的研究现状.环境监测管理与技术,2001,13(2):12-16
36.宋艳涛,王正萍,王厚俊,等.环境空气中多环芳烃的监测研究进展.环境监测管理与技术,2001,13(4):21-24
37.杨克敌主编,衡正昌副主编.环境卫生学(第五版).人民卫生出版社出版,2003
38.刘君卓.室内空气质量与人体健康研究回顾.中国预防医学杂志.2002,3(3):161-163
39.袁晶,夏世钧,室内空气污染与健康.医学与社会,1998,11(2):23-26
40. RobertsonJ. Indoor air quality and sick buildings. Med J Aust 1993;158(5): 358
41. Hoffman RE, et al. Building-related asthma in Denver office worker. Am J Public Health 1993;83(1): 89
42. NRC committee on Indoor Pollutants. In: Spengler JD, Lebowit MD, Hollowell CD, Lippman M, Moschan-dress DJ, Stowijk JAJ, Woods JEJr, Eds. Indoor Pollutants. Washington DC: National Academy Press, 1981
43.胡海红,戴修道.室内空气污染对健康的影响及控制.中国公共卫生,1996,12(1):13-14
44.周中平,赵寿堂.室内污染检测与控制,北京:化学工业出版社,2002.391
45.邵龙义,时宗波.都市大气环境中可吸入颗粒物的研究.环境保护,2000.(1):24-29
46. Pellizzari ED, Clayton CA, Rodes CE, et al. Particulate matter and mangnases exposures in Toronto, Canada. Atmos Environ, 1999, 33: 721-734
47. Geller MD, Chang MC, Sioutas C, et al. Indoor/outdoor relationship and chemical composition of fine and coarse particles in the southern California Deserts. Atmos Environ, 2002, 36: 1099-1110
48. Cao MX, Lin S, Liu JL, et al. Study on human exposure assessment to indoor/outdoor air pollutants. Transac Tianjin Uni, 1997, 3(2): 189-192
49.赵厚银,邵龙义,时宗波.室内空气PM2.5研究现状及发展趋势.环境与健康杂志,2003,20(5):310-312
50. Shima, Masayuki. Indoor nitrogen dioxide in home along trunk roads with heavy traffic. Occup. Envirom. Med. 1998, 55(6): 428-433
51. Lee K, Park E. Residential air quality in wood burning houses in Costa Rica. Symosia of 9th International Conference on Indoor Air Qoality and Climate, 2002, 612-617
52. Furtaw EJ Jr., An overview of human exposure modeling activities at the USEPA's National Exposure Research Laboratory, Toxico Ind Health. 2001 Jun;17(5-10): 302-14
53. Zhang JF, Qian ZM, Kong LZ, et al. Effects of air pollution on respiratory health of adults in there Chinese cities. Archives of Environmental Health, Washington: Nov/Dec 1999, Vol. 54, Iss 6;373-382
54. Xu X, Wang L H. Association of indoor and outdoor particulate Level with Chronic respirator), illness. Am Rev Respir Dis, 1993, 148: 1516-1522
55. Schnart Z, Dockery DW, Lucas MN, et al. Acute effects of Summer air pollution on respiratory symptom reporting in children. Am J Respir M ED, 1994, 150: 1234-1242
56. Brunekreef B, Holgate ST. Air pollution and health, Lancet. 2002 Oct 19;360()9341: 1233-42
57. Glinianaia SV, Rankin J, Bell R, etc., Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. Epidemiology. 2004 Jan;15(1): 36-45
58.董胜璋,张志勇,蔡乘铿,等.工业区大气污染对儿童肺功能影响的研究.环境与健康杂志,1999,16(2):71-73
59.王汉章,等.煤烟型大气污染对儿童肺功能的影响,卫生研究,2003,32(2),138-140
60.岛正之,安藤道子,山内常男.大气污染所带来的学童的肺功能的急性影响和血清lgG.日衡志,2001,56(1):202
61.魏复盛,胡伟,吴国平,等.空气污染与儿童肺功能指标的相关分析.中国环境科学,2001,21(5):389
62.金银龙,等.中国煤烟型大气污染对人群健康危害的定量研究,卫生研究,2002,31(5),342-348
63.席淑华,等.辽宁省工业区大气污染对学龄儿童肺功能影响研究,环境与健康杂志,2001,18(6),374-375
64. Bascom R, Bromberg PA, Costa DA, et al.(Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society). 1999a. Health effects of outdoor air pollution, part 1, Am J Respir Crit Care Med 153: 3-50
65. Bascom R, Bromberg PA, Costa DA, et al.(Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society). 1999b. Health effects of outdoor air pollution, part 2, Am J Respir Crit Care Med 153: 477-498
66. Health Effects Institute, 2001. Airborne Particles and Health: HEI Epidemiological Evidence. HEI Perspectives. Health Effects Institute, Cambridge MA.
67. Health Effects Institute, 2002. Understanding the Health Effects of Components of the Particulate Matter Mix: Progress and Next Steps. HEI Perspectives. Health Effects Institute, Boston MA.
68. Laucas M Neas, Joel Schwartz, Douglas Dockery. A case-crossover analysis of air pollution and mortality in Philadephia. Environ Health Perspect, 1999,107:629-31
69.徐肇翊,刘允清,俞大乾,等.沈阳市大气污染对死亡率的影响,中国公共卫生学报,1996,15(1):61-64
70.阚海东,贾健,陈秉衡.上海市某区居民脑卒中死亡与大气污染关系的时间序列研究,卫生研究,2004,33(1):36-38
71.陈秉衡,洪传洁,朱惠刚,等.上海市城区大气二氧化硫污染对健康影响的定量评价,环境与健康杂志,2002,19(1):11-13
72.常桂秋,潘小川,谢学琴,等.北京市大气污染与城区居民死亡率关系的时间序列分析,卫生研究,2003,32(6):565-568
73.王慧文,潘秀丹,林刚.沈阳市空气二氧化硫污染对心血管疾病死亡率的影响,环境与健康杂志,2002,19(1):50-52
74.王慧文,林刚,潘秀丹.沈阳市大气悬浮颗粒物与心血管疾病死亡率,环境与健康杂志,2003,20(1):13-15
75. Xu X, Gao J, Dockery DW, et al. Air pollution and dairly mortality in residential areas of Beijing, China. Arch Environ Health, 1994, 49(4):216-222
76. Xu Z, Yu D, Xu X, et al. Air pollution and daily mortality in Shenyang, China. Arch Environ Health, 2000, 55(2) :115-120
77. Dockery DW, Pope CA, et al. An Association between air pollution and mortality in six US cities. New Eng J Med 1993, 329:1753
78. Health Effects Institute, 2004, 4. Health Effects of Outdoor Air Pollution in Developing Countries of Asia: A Literature Review, HEI Perspectives. Health Effects Institute, Boston MA.
79. Hedley AJ, Wong GM, Thach TQ, et al. Cardiorespiratory and all-cause mortality after restrictions on sulphur content of fuel in Hong Kong: An intervention study. Lancet 2002, 360 : 1646-1652
80. Hong YC, Leem JH, Ha EH, et al. PM10 exposure, gaseouse pollutants, and daily mortality in Inchon, South Korea. Environ Health Perspect 1999, 107:873-878
81. Lee JT, Kim H, Hong YC, et al. Air pollution and Daily mortality in sev en major cities of Korea, 1991-1997. Environ Res, 2000, 84:247-254
82. Venners SA, Wang B, Peng Z, et al. Particulate matter, sulfur dioxide, and daily mortality in Chongqing, China. Environ Health Perspeet 2003, 111:562-567
83.邓迎东,方积乾.空气污染与健康时间序列资料的传递函数模型的识别与建立.数理医药学杂志,2001,14(4):292-293
84. Jeffrey M. Air pollution and daily mortality in Sydney, Astralia, 1989-1993. Am J Public Health, 1998,88(5) :759-764
85. Katsouyanni. Short-term effects of air pollution on health : a European approach using epidemiological time-series data. Europ Resp J, 1995, 78 (5) :1030-1038
86.马雁军,杨洪斌,方志刚,等.辽宁中部城市群大气污染现状及发展趋势分析,城乡环境与城市生态,2003,16(5):89-91
87. Jong TL, Dong CS, Yong C. Air pollution and daily mortality in Seoul and Ulsan, Korea. Environ Health Perspect, 1999,107 : 149-154
88. Fairley D. Daily mortality and air pollution in Santa Clara county, California: 1989-1996. Environ Health Perspect, 1999, 107:637-641
89. Wong GM, Ma S, Hedley AJ, et al. Effect of air pollution on daily mortalily in Hong Kong. Environ Heahh Perspect, 2001, 109:335-340
90. Ostro B, Chestnut L, Vichit-Vadakan N, et al. The impact of particulate matter on daily mortality in Bangkok, Thailand. J air Waste Manage Assoc 1999, 49 : PM100-PM107
91. Katsouvanni K, Touloumi G, Spix C, et al. Short term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: Results from time series data from the APHEA project. BMJ 314:1658-1663
92. Godleski JJ, Sioutas C, Kattern M, et al. Death from inhalation of concentrated air particles in animal models of pulmary disease. Am J Respir Dis Crit Care Med, 1996, 153 :A15
93. Godleski JJ, Sioutas C, Kattern M, et al. Inhalation exposure of canines to concentrated ambient air particles. Am J Respir Dis Crit Care Med, 1997, 155 : A246
94. Baskert OK. Hematological effects of air pollution. Arch Environ Health, 1990, 45:224-228
95. Liao DP. Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ Health Perspect, 1999, 107:521-525
96. Pope CA. Heart variability associated with particulate air pollution. Am Heart J, 1999, 138:890-899
97. Pope CA. Epidemiology of fine particulate air pollution and human health: Biologic mechanisms and who's at risk. Environ Health Perspect, 2000, 108(4) :713-722
98.魏复盛,Chapman RS.空气污染对呼吸健康影响的研究.北京:中国环境科学出版社,2001,81-105
99. Churg A, Brauer M, Ambient atmospheric particles in the airways of human lungs. Ultrastruct Pathol, 2000 Nov-Dec;24(6) :353-361
100. Chen Y, Yang QY, Daniel K, et al. Influence of Relatively Low Level of Particulate Air Pollution on Hospitalization for COPD in Elderly People. Inhalation Toxicology, 2004, 16:21-25
101. Schweta D. Air pollution and health in urban areas. Rev Environ Health. 2000, Jan-Jun;15 (1-2) : 13-42
102.董景五,徐希平,陈育德,等.1990-1991年北京市城区大气污染与每日居民死亡关系的研究.卫生研究,1995,24(4):212-214
103.罗红,王凤婕,陈小青,等.细颗粒物对呼吸系统疾病作用的研究进展,湖北预防医学杂志,2003,14(3):17-19
104.戴海夏,宋伟民.大气颗粒物健康效应生物学机制研究进展,环境与职业医学,2003,20(4):308-311
105. Becker S, Soukup JM, Gallagher JE, et al. Differential particulate air pollution induced oxidant stressing human granuluytes, monocytes and alveola macrophages. Tox in vitro, 2001, 16:209-218
106. Cassee FR, Muijser H, Duistemate E. et al. Particle size-dependent total mass, deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Arch Toxi, 2002, 76:277-286
2. Ning Tang, Toriba Akird, Kizu Ryoichi, et al. Comparison of atmospheric polycyclic aromatic hydrocarbons and nitropolycylic aromatic hydrocarbons in cities of east. Asia Journal of Ecotechnology Research, 2002, 8(2): 14
3. US EPA office of Air and Radiation, Office of air quality planning and standards fact sheet-EPA's recommended final ozone and particulate matters standards, 1997
4.徐肇翊,金福杰.辽宁城市大气污染造成的居民健康损失及其货币化估计.环境与健康杂志,2003,20(2):67-71
5.刘润香,李鼎.抚顺市大气污染治理成本浅析.辽宁城乡环境科技,2003,23(1):8-10
6.王玮,汤大钢,刘红杰,等.中国PM_(2. 5)污染状况和污染特征的研究.环境科学研究.2000,13(1):1-5
7. Gunter O. Pulmonary effects of inhaled ultrafine particles.(Review)Int Arch Occup Environ Health, 2001, 74: 1-8
8.孙宪民,孙贵范,田村宪治,等.沈阳市大气悬浮颗粒物及PAHS、NPAHS分析.中国公共卫生,2003,19(7):800-802
9. Hayakawa K, Kawaguchi Y, Murahashi T, et al., Distributions of nitropyrenes and mutagenicity in airborne particulates collected with an Andersen sampler, Mutation Res 1995, 348: 57-61
10.武辉,房靖华,钱志强.太原市大气悬颗粒物上多环芳烃的测量与分布研究.中国环境监测,2002,18(4):17-21
11.冯沈迎,高春梅,仝青,等.不同粒径空气颗粒物中11种多环芳烃的分析测定.中国环境监测,2001,17(4):34-37
12.黄业茹,狄一安,施钧慧,等.北京、东京、筑波大气中有机污染物组成研究.环境科学研究,2001,14(1):4-8
13.黄翠玲,徐文箐,赵国栋,等.北京市大气颗粒物中多环芳烃的组成.环境科学,2001,22(4):16-20
14.魏复盛,胡伟,腾恩江,等.空气污染与儿童呼吸系统患病率的相关分析.中国环境科学,2000,20(3):220-224
15.孙强,赵丽,孙德岭,等.我国城市机动车尾气污染防治策略.环境保护,1999,11(2):43-45
16.冯滨,陈能坚.广州市移动源现状及其污染控制管理对策.环境科学研究,1999,12(6):21-24
17.谢绍东,张远航,唐孝炎,等.我国城市地区机动车污染现状与趋势.环境科学研究,2000,13(4):23-25
18.孙宪民.沈阳市大气颗粒物污染现状及对儿童肺功能的影响.博士论文,2003
19. Westerholm R, Li H. A multi-variate statistical analysis of fuel-related polycyclic aromatic hydrocarbone emission from heavy-duty diesel vehicles. Environ Sci Technol, 1994, 28(3): 965-72
20.徐利中,松下秀鹤.空气中多环芳烃的研究现状.环境科学进展,1997,5(5):18-29
21. Durlak SK, Bisowas P, Characterization of polycyclic aromatic hydrocarbones particulate and gaseouse emission from polystyrene combustion. Environ Sci Technol, 1998, 32: 2301-07
22.祈士华.澳门大气气溶胶中多环芳烃研究.环境科学学报,2000,13(4):6-9
23. Khalili NR, Scheff PA, Holssen TM, et al., PAH source fingerprints of cook ovens, diesel and gasline engine heavy trucks and wood combusion emissions. Atmospheric Environment, 1995, 29: 533-42
24.袁彦华,孙连军,郭秀兰,等.多环芳烃化合物毒理学研究.中国公共卫生,1999,15(8):675-76
25.杨文敏,吴丙耀,乌亚萍,等.大气颗粒物提取物的致突变性.中国公共卫生学报,1994,13(20):119-121
26.孙成均,田边(氵絜),小谷野道子,等,空气悬浮颗粒物中硝基多环芳烃多环芳烃化合物粒径分布的研究.现代预防医学,1994,21(3):129-132
27. George T. Wolff. Measurement of Hazards in Particles at a Rural Site on Atlantic Coast, for the Presentation to the 78th Anounce Meeting of Air Pol lution Control Association. 1985, 6, 1621
28. Greenborg A, PAH in New Jersy: A comparion of winter and summer concentration over a two-year period. Atmos Environ, 1998, 19(8): 1325-1339
29.姚渭溪.电厂燃煤锅排放烟尘和多环芳烃的分布及突变特征.环境科学,1993,53(15):3486-92
30.张文丽,徐东群,崔九思,等.空气细颗粒物污染特征及毒性机制的研究进展.中国环境监测,2002,18(1):59-63
31.阚海东,陈秉衡.我国部分城市大气污染对健康影响的研究十年回顾.中国预防医学杂志,2002,36(10):59-61
32.井立滨,秦怡,徐肇翊.本溪市大气污染对慢性呼吸系统疾病的关系.环境与健康杂志,2000,17(5):268-70
33.刘文影,董胜章.机动车尾气慢性毒性效应的研究进展.环境与健康杂志,2002,19(5):413-15
34.夏慧丽,倪小明,陈孟林,等.大气中多环芳烃的研究现状与展望.广西师范大学学报(自然科学版),2003,21(2):67-70
35.完莉莉,汪玉庭.室内空气有机污染的研究现状.环境监测管理与技术,2001,13(2):12-16
36.宋艳涛,王正萍,王厚俊,等.环境空气中多环芳烃的监测研究进展.环境监测管理与技术,2001,13(4):21-24
37.杨克敌主编,衡正昌副主编.环境卫生学(第五版).人民卫生出版社出版,2003
38.刘君卓.室内空气质量与人体健康研究回顾.中国预防医学杂志.2002,3(3):161-163
39.袁晶,夏世钧,室内空气污染与健康.医学与社会,1998,11(2):23-26
40. RobertsonJ. Indoor air quality and sick buildings. Med J Aust 1993;158(5): 358
41. Hoffman RE, et al. Building-related asthma in Denver office worker. Am J Public Health 1993;83(1): 89
42. NRC committee on Indoor Pollutants. In: Spengler JD, Lebowit MD, Hollowell CD, Lippman M, Moschan-dress DJ, Stowijk JAJ, Woods JEJr, Eds. Indoor Pollutants. Washington DC: National Academy Press, 1981
43.胡海红,戴修道.室内空气污染对健康的影响及控制.中国公共卫生,1996,12(1):13-14
44.周中平,赵寿堂.室内污染检测与控制,北京:化学工业出版社,2002.391
45.邵龙义,时宗波.都市大气环境中可吸入颗粒物的研究.环境保护,2000.(1):24-29
46. Pellizzari ED, Clayton CA, Rodes CE, et al. Particulate matter and mangnases exposures in Toronto, Canada. Atmos Environ, 1999, 33: 721-734
47. Geller MD, Chang MC, Sioutas C, et al. Indoor/outdoor relationship and chemical composition of fine and coarse particles in the southern California Deserts. Atmos Environ, 2002, 36: 1099-1110
48. Cao MX, Lin S, Liu JL, et al. Study on human exposure assessment to indoor/outdoor air pollutants. Transac Tianjin Uni, 1997, 3(2): 189-192
49.赵厚银,邵龙义,时宗波.室内空气PM2.5研究现状及发展趋势.环境与健康杂志,2003,20(5):310-312
50. Shima, Masayuki. Indoor nitrogen dioxide in home along trunk roads with heavy traffic. Occup. Envirom. Med. 1998, 55(6): 428-433
51. Lee K, Park E. Residential air quality in wood burning houses in Costa Rica. Symosia of 9th International Conference on Indoor Air Qoality and Climate, 2002, 612-617
52. Furtaw EJ Jr., An overview of human exposure modeling activities at the USEPA's National Exposure Research Laboratory, Toxico Ind Health. 2001 Jun;17(5-10): 302-14
53. Zhang JF, Qian ZM, Kong LZ, et al. Effects of air pollution on respiratory health of adults in there Chinese cities. Archives of Environmental Health, Washington: Nov/Dec 1999, Vol. 54, Iss 6;373-382
54. Xu X, Wang L H. Association of indoor and outdoor particulate Level with Chronic respirator), illness. Am Rev Respir Dis, 1993, 148: 1516-1522
55. Schnart Z, Dockery DW, Lucas MN, et al. Acute effects of Summer air pollution on respiratory symptom reporting in children. Am J Respir M ED, 1994, 150: 1234-1242
56. Brunekreef B, Holgate ST. Air pollution and health, Lancet. 2002 Oct 19;360()9341: 1233-42
57. Glinianaia SV, Rankin J, Bell R, etc., Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. Epidemiology. 2004 Jan;15(1): 36-45
58.董胜璋,张志勇,蔡乘铿,等.工业区大气污染对儿童肺功能影响的研究.环境与健康杂志,1999,16(2):71-73
59.王汉章,等.煤烟型大气污染对儿童肺功能的影响,卫生研究,2003,32(2),138-140
60.岛正之,安藤道子,山内常男.大气污染所带来的学童的肺功能的急性影响和血清lgG.日衡志,2001,56(1):202
61.魏复盛,胡伟,吴国平,等.空气污染与儿童肺功能指标的相关分析.中国环境科学,2001,21(5):389
62.金银龙,等.中国煤烟型大气污染对人群健康危害的定量研究,卫生研究,2002,31(5),342-348
63.席淑华,等.辽宁省工业区大气污染对学龄儿童肺功能影响研究,环境与健康杂志,2001,18(6),374-375
64. Bascom R, Bromberg PA, Costa DA, et al.(Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society). 1999a. Health effects of outdoor air pollution, part 1, Am J Respir Crit Care Med 153: 3-50
65. Bascom R, Bromberg PA, Costa DA, et al.(Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society). 1999b. Health effects of outdoor air pollution, part 2, Am J Respir Crit Care Med 153: 477-498
66. Health Effects Institute, 2001. Airborne Particles and Health: HEI Epidemiological Evidence. HEI Perspectives. Health Effects Institute, Cambridge MA.
67. Health Effects Institute, 2002. Understanding the Health Effects of Components of the Particulate Matter Mix: Progress and Next Steps. HEI Perspectives. Health Effects Institute, Boston MA.
68. Laucas M Neas, Joel Schwartz, Douglas Dockery. A case-crossover analysis of air pollution and mortality in Philadephia. Environ Health Perspect, 1999,107:629-31
69.徐肇翊,刘允清,俞大乾,等.沈阳市大气污染对死亡率的影响,中国公共卫生学报,1996,15(1):61-64
70.阚海东,贾健,陈秉衡.上海市某区居民脑卒中死亡与大气污染关系的时间序列研究,卫生研究,2004,33(1):36-38
71.陈秉衡,洪传洁,朱惠刚,等.上海市城区大气二氧化硫污染对健康影响的定量评价,环境与健康杂志,2002,19(1):11-13
72.常桂秋,潘小川,谢学琴,等.北京市大气污染与城区居民死亡率关系的时间序列分析,卫生研究,2003,32(6):565-568
73.王慧文,潘秀丹,林刚.沈阳市空气二氧化硫污染对心血管疾病死亡率的影响,环境与健康杂志,2002,19(1):50-52
74.王慧文,林刚,潘秀丹.沈阳市大气悬浮颗粒物与心血管疾病死亡率,环境与健康杂志,2003,20(1):13-15
75. Xu X, Gao J, Dockery DW, et al. Air pollution and dairly mortality in residential areas of Beijing, China. Arch Environ Health, 1994, 49(4):216-222
76. Xu Z, Yu D, Xu X, et al. Air pollution and daily mortality in Shenyang, China. Arch Environ Health, 2000, 55(2) :115-120
77. Dockery DW, Pope CA, et al. An Association between air pollution and mortality in six US cities. New Eng J Med 1993, 329:1753
78. Health Effects Institute, 2004, 4. Health Effects of Outdoor Air Pollution in Developing Countries of Asia: A Literature Review, HEI Perspectives. Health Effects Institute, Boston MA.
79. Hedley AJ, Wong GM, Thach TQ, et al. Cardiorespiratory and all-cause mortality after restrictions on sulphur content of fuel in Hong Kong: An intervention study. Lancet 2002, 360 : 1646-1652
80. Hong YC, Leem JH, Ha EH, et al. PM10 exposure, gaseouse pollutants, and daily mortality in Inchon, South Korea. Environ Health Perspect 1999, 107:873-878
81. Lee JT, Kim H, Hong YC, et al. Air pollution and Daily mortality in sev en major cities of Korea, 1991-1997. Environ Res, 2000, 84:247-254
82. Venners SA, Wang B, Peng Z, et al. Particulate matter, sulfur dioxide, and daily mortality in Chongqing, China. Environ Health Perspeet 2003, 111:562-567
83.邓迎东,方积乾.空气污染与健康时间序列资料的传递函数模型的识别与建立.数理医药学杂志,2001,14(4):292-293
84. Jeffrey M. Air pollution and daily mortality in Sydney, Astralia, 1989-1993. Am J Public Health, 1998,88(5) :759-764
85. Katsouyanni. Short-term effects of air pollution on health : a European approach using epidemiological time-series data. Europ Resp J, 1995, 78 (5) :1030-1038
86.马雁军,杨洪斌,方志刚,等.辽宁中部城市群大气污染现状及发展趋势分析,城乡环境与城市生态,2003,16(5):89-91
87. Jong TL, Dong CS, Yong C. Air pollution and daily mortality in Seoul and Ulsan, Korea. Environ Health Perspect, 1999,107 : 149-154
88. Fairley D. Daily mortality and air pollution in Santa Clara county, California: 1989-1996. Environ Health Perspect, 1999, 107:637-641
89. Wong GM, Ma S, Hedley AJ, et al. Effect of air pollution on daily mortalily in Hong Kong. Environ Heahh Perspect, 2001, 109:335-340
90. Ostro B, Chestnut L, Vichit-Vadakan N, et al. The impact of particulate matter on daily mortality in Bangkok, Thailand. J air Waste Manage Assoc 1999, 49 : PM100-PM107
91. Katsouvanni K, Touloumi G, Spix C, et al. Short term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: Results from time series data from the APHEA project. BMJ 314:1658-1663
92. Godleski JJ, Sioutas C, Kattern M, et al. Death from inhalation of concentrated air particles in animal models of pulmary disease. Am J Respir Dis Crit Care Med, 1996, 153 :A15
93. Godleski JJ, Sioutas C, Kattern M, et al. Inhalation exposure of canines to concentrated ambient air particles. Am J Respir Dis Crit Care Med, 1997, 155 : A246
94. Baskert OK. Hematological effects of air pollution. Arch Environ Health, 1990, 45:224-228
95. Liao DP. Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly. Environ Health Perspect, 1999, 107:521-525
96. Pope CA. Heart variability associated with particulate air pollution. Am Heart J, 1999, 138:890-899
97. Pope CA. Epidemiology of fine particulate air pollution and human health: Biologic mechanisms and who's at risk. Environ Health Perspect, 2000, 108(4) :713-722
98.魏复盛,Chapman RS.空气污染对呼吸健康影响的研究.北京:中国环境科学出版社,2001,81-105
99. Churg A, Brauer M, Ambient atmospheric particles in the airways of human lungs. Ultrastruct Pathol, 2000 Nov-Dec;24(6) :353-361
100. Chen Y, Yang QY, Daniel K, et al. Influence of Relatively Low Level of Particulate Air Pollution on Hospitalization for COPD in Elderly People. Inhalation Toxicology, 2004, 16:21-25
101. Schweta D. Air pollution and health in urban areas. Rev Environ Health. 2000, Jan-Jun;15 (1-2) : 13-42
102.董景五,徐希平,陈育德,等.1990-1991年北京市城区大气污染与每日居民死亡关系的研究.卫生研究,1995,24(4):212-214
103.罗红,王凤婕,陈小青,等.细颗粒物对呼吸系统疾病作用的研究进展,湖北预防医学杂志,2003,14(3):17-19
104.戴海夏,宋伟民.大气颗粒物健康效应生物学机制研究进展,环境与职业医学,2003,20(4):308-311
105. Becker S, Soukup JM, Gallagher JE, et al. Differential particulate air pollution induced oxidant stressing human granuluytes, monocytes and alveola macrophages. Tox in vitro, 2001, 16:209-218
106. Cassee FR, Muijser H, Duistemate E. et al. Particle size-dependent total mass, deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Arch Toxi, 2002, 76:277-286