具有介孔表面磁性纳米复合材料的制备与研究
|
摘要
四氧化三铁纳米材料在很多领域都具有广泛的应用,合成尺寸和形貌可控的纳米颗粒及其复合物日益成为磁性纳米材料研究中的热点。近几年纳米材料的合成方法取得重大进展,利用各种不同的方法制备得到了一系列单分散的金属或金属氧化物的纳米颗粒。在磁性纳米氧化铁的合成及应用研究中,溶剂热方法由于其简便操作、容易控制的实验条件和好的实验重复性,得到了较高的关注。本论文采用溶剂热的方法,制备出具有超顺磁性的四氧化三铁磁性纳米颗粒。以这种方法合成得到的四氧化三铁纳米颗粒为基础,通过化学修饰以及模板法制备出了具有介孔二氧化硅表面的磁性纳米氧化铁微球,并进一步通过对照实验比较了这种具有介孔表面结构特征的材料与传统材料的应用优势。具体研究内容如下：
1.在乙二醇氛围下,利用氯化铁作为起始原料采用溶剂热法制备出四氧化三铁纳米微粒。并比较了加入己二胺作为形貌控制剂和不加入己二胺反应条件下对产物的不同影响,初步探讨了几种关键因素的作用。
2.通过硅胶包覆保护四氧化三铁纳米微粒作为核,以十六烷基三甲基溴化铵(CTAB)为模板剂,采用改进的脱模板方法得到了具有介孔表面的磁性氧化铁微球。
3.对比得到的介孔氧化铁微球和经过氨基化修饰的硅胶包覆氧化铁微球以及硅胶包覆的氧化铁微球等三种材料对于利巴韦林的吸附。发现该类具有介孔表面的磁性纳米氧化铁微球相对其他两种材料具有更好的吸附性能及优良的重复利用率。
Magnetic nanoparticles (MNPs) have been of great interests because of their extensive applications. The synthesis of this type of materials, such as monodisperse metal and metaloxide nanoparticles have been provided in recent years. This study focused on the solvothermal method synthesis of Fe3O4 nanoparticles and prepared mesoporous Fe3O4-SiO2 nanocomposite. The solvothermal method is easy controlled and offered a good reproducibility. In the process of preparing mesoporous Fe3O4 nanocomposite, we use the hexadecyl trimethyl ammonium bromide (HTAB) as the micelle template and use an improved method to remove this template. Finally, we got the mesoporous Fe3O4 nanocomposite and compared the adsorption ability of this material to that of the-NH2 functionalized Fe3O4 nanoparticles. The result showed that mesoporous Fe3O4 nanoconposite has a better ability of adsorption and good reuseability. The content of this thesis is as following:
1.Under the ethylene glycol circumstance, using iron chloride as starting material, we synthesis Fe3O4 nanoparticles and compare the difference between two experimental processes, with and without hexamethylene diamine.
2.Fe3O4-SiO2 nanocomposite were prepared by the storb method. This material was used as core to prepare the mesoporous nanocomposite with the HTAB template. A Soxhlet extraction method was used in removing template process.
3.Three different materials, mesoporous Fe3O4 nanocomposite,-NH2 functionalized Fe3O4 nanocomposite and Fe3O4-SiO2 were used to compare the adsorption of ribavirin, the result proving that the mesoporous Fe3O4 nanocomposite has the best adsorption ability and good reuseability.
1.在乙二醇氛围下,利用氯化铁作为起始原料采用溶剂热法制备出四氧化三铁纳米微粒。并比较了加入己二胺作为形貌控制剂和不加入己二胺反应条件下对产物的不同影响,初步探讨了几种关键因素的作用。
2.通过硅胶包覆保护四氧化三铁纳米微粒作为核,以十六烷基三甲基溴化铵(CTAB)为模板剂,采用改进的脱模板方法得到了具有介孔表面的磁性氧化铁微球。
3.对比得到的介孔氧化铁微球和经过氨基化修饰的硅胶包覆氧化铁微球以及硅胶包覆的氧化铁微球等三种材料对于利巴韦林的吸附。发现该类具有介孔表面的磁性纳米氧化铁微球相对其他两种材料具有更好的吸附性能及优良的重复利用率。
Magnetic nanoparticles (MNPs) have been of great interests because of their extensive applications. The synthesis of this type of materials, such as monodisperse metal and metaloxide nanoparticles have been provided in recent years. This study focused on the solvothermal method synthesis of Fe3O4 nanoparticles and prepared mesoporous Fe3O4-SiO2 nanocomposite. The solvothermal method is easy controlled and offered a good reproducibility. In the process of preparing mesoporous Fe3O4 nanocomposite, we use the hexadecyl trimethyl ammonium bromide (HTAB) as the micelle template and use an improved method to remove this template. Finally, we got the mesoporous Fe3O4 nanocomposite and compared the adsorption ability of this material to that of the-NH2 functionalized Fe3O4 nanoparticles. The result showed that mesoporous Fe3O4 nanoconposite has a better ability of adsorption and good reuseability. The content of this thesis is as following:
1.Under the ethylene glycol circumstance, using iron chloride as starting material, we synthesis Fe3O4 nanoparticles and compare the difference between two experimental processes, with and without hexamethylene diamine.
2.Fe3O4-SiO2 nanocomposite were prepared by the storb method. This material was used as core to prepare the mesoporous nanocomposite with the HTAB template. A Soxhlet extraction method was used in removing template process.
3.Three different materials, mesoporous Fe3O4 nanocomposite,-NH2 functionalized Fe3O4 nanocomposite and Fe3O4-SiO2 were used to compare the adsorption of ribavirin, the result proving that the mesoporous Fe3O4 nanocomposite has the best adsorption ability and good reuseability.
引文
[1].张立德,牟季美,纳米材料与纳米技术,科学出版社,2001年2月,74-78
[2]. Dirksen, J. A., Ring, T. A., Fundamentals of crystallization:Kinetic effects on particle size distributions and morphology, Chem. Eng. Sci.1991,46,2389-2427
[3]. Fu, L., V.P. David, D.L.Johnson, Self_assembled (SA) bilayer molecular coating on magnetic nanoparticles, Appl. Sulf. Sci.2001,181(1-2):173-178.
[4]. Kataby, G., Self-assembled monolayer coatings on amorphous iron and iron oxid nanoparticles:Thermal stability and chemical reactivity studies, Langmuir 1997,13(23):6151-6158)
[5]. L Wang,J Luo,M M Maye,et al.Iron oxide-gold core-shell nanoparticles and thin film assembly.J.Mater.Chem.,2005,15(18):1821-1832.
[6]. Sugimoto T,Matijevic E.Formation of uniform spherical magnetic particles by crystallization from ferrous hydroxide gels.J Colloid Interf Sci,1980,74 (1): 227-243.
[7]. GunkoY. K., Pillai, S. C., McInerney D., J. Mater. Sci., Mater.Electron.,2001, 12,299-302.
[8].周洁,马明,张宇等。东南大学学报(J. Southeast Univ.),2005,35(4): 616-618.
[9]. Y. Hou, J. Yu, S. Gao, Solvothermal reduction synthesis and characterization of suerparamagnetic magnetite nanoparticles, Electronic. J. Mater. Chem.,2003, 13(8):1983-1987.
[10]. K. Deshpande, M. Nersesyan, A. Mukasyan, et al. Novel haracterizat iron oxide nanopowders,.Ind. Eng. Chem. Res.,2005,44(16):6196-6199.
[11].施尔畏,夏长泰,王步国等,水热法的应用与发展,无机材料学报,1996,11(2)：193-206.
[12]. Tang K. B., Hu J. Q., Lu Q. Y, Adv. Mater.,1999,11 653
[13]. Li Y. D., Duan X. F., Qian Y. T., J. Am. Chem. Soc.,1997,119,7869
[14]. Li Y., Liao H., Ding Y., et al. Inorg. Chem.,1999,38,1382
[15]. Demazeau G. J. Mater. Chem.,1999,9,15
[16].杨华,黄可龙,刘素琴,磁性材料及器件,2003,34(2),4-6
[17]. Sahoo Y, Pizem H, Fried T, et al.Alkyl phosphonate/phosphate coating on magnetite nanoparticles:A comparison with fatty acids. Langmuir,2001,17(25): 7907-7911.
[18]. M H Sousa,J C Rubim,P G Sobrinho,et al.Biocompatible magnetic fluid precursors based on aspartic and glutamic acid modified maghemite nanostructures. J.Magn.Magn.Mater.,2001,225(1-2):67-72.
[19]. Morais P C,Oliveira A C,Tronconi A L,et al.Photoacoustic spectroscopy:a promising technique to investigate magnetic fluids IEEE Trans.Magn.,2003, 39(5):2654-2656.
[20]. Y Sahoo, A Goodarzi,M T Swihart,et al.Aqueous ferrofluid of magnetite nanoparticles:Fluorescence labeling and magnetophoretic control J.Phys.Chem. B,2005,109(9):3879-3885.
[21]. Xie J,Wang C.Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel.Pharm.Res.,2005,22(12):2079-2090.
[22]. Mornet S,Vasseur S,Grasset F,et al.Magnetic nanoparticle design for medical diagnosis and therapy J.Mater.Chem.,2004,14(14):2161-2175.
[23]. Bonacchi D,Caneschi A,Gatteschi D,et al.Synthesis and haracterization of metal oxides nanoparticles entrapped in cyclodextrin.J.Phys.Chem.Solids, 2004,65(4):719-722.
[24]. Bonacchi D,Caneschi A,Dorignac D,et al.Nanosized iron oxide particles entrapped in pseudo-single crystals ofy-cyclodextrin, Chem. Mater.,2004,16(10): 2016-2020.
[25]. D Caruntu,B L Cushing,G Caruntu,et al.Attachment of gold nanograins onto colloidal magnetite nanocrystals.Chem.Mater.,2005,17(13):3398-3402.
[26]. Ma M,Zhang Y,Yu W,et al.Preparation and characterization of magnetite nanoparticles coated by amino silane Colloids surf.A,2003,212(2-3):219-226.
[27]. Gupta A. K, Wells S., Surface-modified superparamagnetic nanoparticles for drug delivery:preparation, characterization, and cytotoxicity studies, IEEE Trans. Nanobio sci.,2004,3(1):66-73.
[28]. Gupta A. K, Curtis A. S. G, Surface modified superparamagnetic nanoparticles for drug delivery:Interaction studies with human fibroblasts in culture, J. Mater. Sci. Mater. Med.,2004,15(4):493-496.
[29]. D'Souza A. J., Schowen R. L., Topp E. M., Polyvinylpyrrolidone-drug conjugate:synthesis and release mechanism.J.Control Release,2004,94(1):91-100.
[30]. Pardoe H., Chua-anusorn W., St.Pierre T., G,et al.Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol.J.Magn.Magn.Mater.,2001,225(1-2):41-46.
[31]. Kim D. K., Mikhaylova M., Topark M., et al. Synthesis and Characterization of Magnetic Polymeric Nanospheres for Biomedical Applications, Mat. Res. Soc. Symp. Proc.,2003,750,Y9.2.1.
[32]. Singh H., Laibinis P. E., Hatton T. A. Rigid, superparamagnetic chains of permanently linked beads coated with magnetic nanoparticles.synthesis and rotational dynamics under applied magnetic fields, Langmuir,2005,21(24): 11500-11509.
[33].安丽娟,李兆强,王燕萍,等.超顺磁性高分子微球的制备与表征高等学校化学学报,2006,27(7)：1372-1375.
[34]. Shan G. B., Xing J. M., Luo M. F., et al. Immobilization of Pseudomonas delafieldii with magnetic polyvinyl alcohol beads and its application in biodesulfurization, Biotechnol. Lett.,2003,25(23):1977-1981.
[35]. Stephane Mornet, Josik Portier, Etienne Duguet, A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran. Journal of Magnetism and Magnetic Materials.2005; 293:127-134.
[36]. R. S. Molday and D. Mackenzie, Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells, J. Immunol. Methods.1982; 52:353-367.
[37]. Kim D. K., Mikhaylova M., Zhang Y, et al. Protective coating of superparamagnetic iron oxide nanoparticles.Chem.Mater.,2003,15(8):1617-1627.
[38]. Kim D. K., Mikhaylova M., Wang F. H., et al. Starch-Coated Superparamagnetic Nanoparticles as MR Contrast Agents, Chem. Mater.,2003, 15(23):4343-4351.
[39]. Olsen D,Yang C,Bodo M,et al.Recombinant collagen and gelatin for drug delivery, Adv. Drug Deliv. Rev.,2003,55(12):1547-1567.
[40]. Bodnar M,Hartmann JF,Borbely J.Preparation and characterization of chitosan-based nanoparticles.Biomacromolecules.2005;6(5):2521-2527.
[41]. Chang YC,Chen DH.Preparation and adsorption properties of monodisperse chitosan-bound Fe3O4 magnetic nanoparticles for removal of Cu(II)ions.J Colloid Interface Sci.2005; 283(2):446-451.
[42]. Burke N. A. D., Stover H. D. H., Dawson F. P., Magnetic Nanocomposites: Preparation and Characterization of Polymer-Coated Iron Nanoparticles Chem. Mater.,2002,14(11):4752-4761.
[43]. B L Frankamp,A K Boal,M T Tuominen,et al.Direct control of the magnetic interaction between iron oxide nanoparticles through dendrimer-mediated self-assembly. J. Am. Chem. Soc.,2005,127(27):9731-9735.
[44]. He H W,Liu H J,Zhou K C,et al.Characteristics of magnetic Fe3O4 nanoparticles encapsulated with human serum albumin. J. Cent. South Univ. T., 2006,13(1):6-11.
[45]. Mikhaylova M,Kim D K,Berry C C,et al.BSA immobilization on amine-functionalized superparamagnetic iron oxide nanoparticles Chem. Mater., 2004,16(12):2344-2354.
[46]. Lewin M,Carlesso N,Tung C-H,et al.Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol.,2000,18(4):410-414.
[47]. D G Georganopoulou,L Chang,Nam J M,et al.Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc. Natl. Acad. Sci. USA,2005,102(7):2273-2276.
[48]. Weizmann Y,Patolsky F,Lioubashevski O,I.Willner,Magneto-mechanical detection of nucleic acids and telomerase activity in cancer cells, J. Am. Chem. Soc.,2004,126(4):1073-1080.
[49]. Zhang Chunfu, Cao Jinquan, Yin Duanzhi, Wang Yongxian, Feng Yanlin, Tan Jiaju, Preparation and radiolabeling of human serum albumin(I)-coated magnetite nanoparticles for magnetically targeted therapy, Applied Radiation and Isotopes 2004; 61:1255-1259.
[50]. L. Wang, J. Bao, L. Wang, F. Zhang, Y. D. Li, One-pot synthesis and bioapplication of amine-functionalized magnetite nanoparticles and hollow nanospheres, Chem. Eur. J.2006,12,6341-6347.
[51]. D. R. Amorin, X. Wang, M. Gaboyard, R. Clerac, S. Nlate, K. Heuze, Dendron-Functionalized Core-Shell Superparamagnetic Nanoparticles: Magnetically Recoverable and Reusable Catalysts For Suzuki C-C Cross-Coupling Reactions, Chem. Eur. J.2009. (In Press)
[52]. Y. Chan, John P. Zimmer, M. Stroh, J. S. Steckel, R. K. Jain, M. G. Bawendi, Incorporation of luminescent nanocrystals into monodisperse Core-Shell silica microspheres, Adv. Mater.2004,16,23-24.
[53]. S. I. Stoeva, F. Huo, J-S Lee, et al. Three-layer composite magnetic nanoparticle probes for DNA, J. Am. Chem. Soc.,2005,127(44):15362-15363.
[54]. P. Wu, J. Zhu, Z. Xu, Template-assisted synthesis of mesoporous magnetic nanocomposite particles, Adv. Funct. Mater.2004,14,345-351.
[55]. W. Zhao, J. Gu, L. Zhang, H. Chen, J. Shi, Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure, J. Am. Chem. Soc,2005,127,8916-8917.
[56]. Y. Deng, D. Qi, C. Deng, X. Zhang, D. Zhao, superparamagnetic high-magnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesorporous SiO2 shell for removal of microcystins, J. Am. Chem. Soc., 2008,130,28-29.
[57]. M. Shokouhimehr, Y. Piao, J. Kim, Y. Jang, T. Hyeon, a magnetically recyclable nanocomposite catalyst for olefin epoxidation, J. Am. Chem. Soc., 2007,46,7039-7043.
[58]. A. J. Rosengart, M. D. Kaminski, H. Chen, P. L. Caviness, A. D. Ebner, J. A. Ritter, Magnetizable implants and functionalized magnetic carriers:A novel approach for noninvasive yet targeted drug delivery, J. Magn. Magn. Mater.,2005, 293,633-638.
[59]. X. Q. Xu, C. H. Deng, M. X. Gao, W. J. Yu, P. Y. Yang, X. G. Zhang, Synthesis of Magnetic Microspheres with Immobilizated Metal Ions for Enrichment and Direct Determination of Phosphopeptides by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry, Adv. Mater.2006,18, 3289-3293.
[60]. C. J Tan, H. G. Chua, K. H. Ker, Y. W. Tong, Preparation of Bovine Serum Albumin Surface-Imprinted Submicrometer Particles with Magnetic Susceptibility through Core-Shell Miniemulsion Polymerization, Anal. Chem., 2008,80,683-692.
[61]. L. Wang, J. Bao, L. Wang, F. Zhang, Y. Li, One-Pot Synthesis and Bioapplication of Amine-Functionlized Magnetite Nanoparticles and Hollow Nanospheres, Chem. Eur. J.2006,12,6341-6347.
[62]. Y. Sun, Y. Xia, Science,2002,298,2176-2179
[63]. Y L. Wang, Y. N. Xia, Nano. Lett.,2004,4,2047-2050.
[64]. G. Viau, R. Brayner, L. Poul, N. Chakroune, E. Lacaze, F. Fievet-Vincent, Chem. Mater.,2003,15,486-494.
[65]. K. R. Brown, D. G. Walter, M. J. Natan, Chem. Mater.2000,12,306-313.
[66]. X. Q. Xu, C. H. Deng, M. X. Gao, W. J. Yu, P. Y. Yang, X. M. Zhang, Adv. Mater.,2006,18,3289-3291.
[67]. Templated-Assisted Synthesis of Mesoporous Magnetic Nanocomposite Particles, P. Wu, J. Zhu, Zh. Xu, Adv. Funct. Mater.,2004,14,345-351.
[68]. Fabrication of Uniform Magnetic Nanocomposite Spheres with a Magnetic Core/Mesoporous Silica Shell Structure, W. Zhao, J. Gu, L. Zhang, H. Chen, J. Shi, J. Am. Chem. Soc.,2005,127,8916-8917.
[69]. Superparamagnetic High-Magnetization Microspheres with an Fe3O4@SiO2 Core and Perpendicularly Aligned Mesoporous SiO2 Shell for Removal of Microcystins, Y.H. Deng, D.W. Qi, C.H. Deng, X.M. Zhang, D.Y. Zhao, J. Am. Chem. Soc.,2008,130,28-29.
[2]. Dirksen, J. A., Ring, T. A., Fundamentals of crystallization:Kinetic effects on particle size distributions and morphology, Chem. Eng. Sci.1991,46,2389-2427
[3]. Fu, L., V.P. David, D.L.Johnson, Self_assembled (SA) bilayer molecular coating on magnetic nanoparticles, Appl. Sulf. Sci.2001,181(1-2):173-178.
[4]. Kataby, G., Self-assembled monolayer coatings on amorphous iron and iron oxid nanoparticles:Thermal stability and chemical reactivity studies, Langmuir 1997,13(23):6151-6158)
[5]. L Wang,J Luo,M M Maye,et al.Iron oxide-gold core-shell nanoparticles and thin film assembly.J.Mater.Chem.,2005,15(18):1821-1832.
[6]. Sugimoto T,Matijevic E.Formation of uniform spherical magnetic particles by crystallization from ferrous hydroxide gels.J Colloid Interf Sci,1980,74 (1): 227-243.
[7]. GunkoY. K., Pillai, S. C., McInerney D., J. Mater. Sci., Mater.Electron.,2001, 12,299-302.
[8].周洁,马明,张宇等。东南大学学报(J. Southeast Univ.),2005,35(4): 616-618.
[9]. Y. Hou, J. Yu, S. Gao, Solvothermal reduction synthesis and characterization of suerparamagnetic magnetite nanoparticles, Electronic. J. Mater. Chem.,2003, 13(8):1983-1987.
[10]. K. Deshpande, M. Nersesyan, A. Mukasyan, et al. Novel haracterizat iron oxide nanopowders,.Ind. Eng. Chem. Res.,2005,44(16):6196-6199.
[11].施尔畏,夏长泰,王步国等,水热法的应用与发展,无机材料学报,1996,11(2)：193-206.
[12]. Tang K. B., Hu J. Q., Lu Q. Y, Adv. Mater.,1999,11 653
[13]. Li Y. D., Duan X. F., Qian Y. T., J. Am. Chem. Soc.,1997,119,7869
[14]. Li Y., Liao H., Ding Y., et al. Inorg. Chem.,1999,38,1382
[15]. Demazeau G. J. Mater. Chem.,1999,9,15
[16].杨华,黄可龙,刘素琴,磁性材料及器件,2003,34(2),4-6
[17]. Sahoo Y, Pizem H, Fried T, et al.Alkyl phosphonate/phosphate coating on magnetite nanoparticles:A comparison with fatty acids. Langmuir,2001,17(25): 7907-7911.
[18]. M H Sousa,J C Rubim,P G Sobrinho,et al.Biocompatible magnetic fluid precursors based on aspartic and glutamic acid modified maghemite nanostructures. J.Magn.Magn.Mater.,2001,225(1-2):67-72.
[19]. Morais P C,Oliveira A C,Tronconi A L,et al.Photoacoustic spectroscopy:a promising technique to investigate magnetic fluids IEEE Trans.Magn.,2003, 39(5):2654-2656.
[20]. Y Sahoo, A Goodarzi,M T Swihart,et al.Aqueous ferrofluid of magnetite nanoparticles:Fluorescence labeling and magnetophoretic control J.Phys.Chem. B,2005,109(9):3879-3885.
[21]. Xie J,Wang C.Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel.Pharm.Res.,2005,22(12):2079-2090.
[22]. Mornet S,Vasseur S,Grasset F,et al.Magnetic nanoparticle design for medical diagnosis and therapy J.Mater.Chem.,2004,14(14):2161-2175.
[23]. Bonacchi D,Caneschi A,Gatteschi D,et al.Synthesis and haracterization of metal oxides nanoparticles entrapped in cyclodextrin.J.Phys.Chem.Solids, 2004,65(4):719-722.
[24]. Bonacchi D,Caneschi A,Dorignac D,et al.Nanosized iron oxide particles entrapped in pseudo-single crystals ofy-cyclodextrin, Chem. Mater.,2004,16(10): 2016-2020.
[25]. D Caruntu,B L Cushing,G Caruntu,et al.Attachment of gold nanograins onto colloidal magnetite nanocrystals.Chem.Mater.,2005,17(13):3398-3402.
[26]. Ma M,Zhang Y,Yu W,et al.Preparation and characterization of magnetite nanoparticles coated by amino silane Colloids surf.A,2003,212(2-3):219-226.
[27]. Gupta A. K, Wells S., Surface-modified superparamagnetic nanoparticles for drug delivery:preparation, characterization, and cytotoxicity studies, IEEE Trans. Nanobio sci.,2004,3(1):66-73.
[28]. Gupta A. K, Curtis A. S. G, Surface modified superparamagnetic nanoparticles for drug delivery:Interaction studies with human fibroblasts in culture, J. Mater. Sci. Mater. Med.,2004,15(4):493-496.
[29]. D'Souza A. J., Schowen R. L., Topp E. M., Polyvinylpyrrolidone-drug conjugate:synthesis and release mechanism.J.Control Release,2004,94(1):91-100.
[30]. Pardoe H., Chua-anusorn W., St.Pierre T., G,et al.Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol.J.Magn.Magn.Mater.,2001,225(1-2):41-46.
[31]. Kim D. K., Mikhaylova M., Topark M., et al. Synthesis and Characterization of Magnetic Polymeric Nanospheres for Biomedical Applications, Mat. Res. Soc. Symp. Proc.,2003,750,Y9.2.1.
[32]. Singh H., Laibinis P. E., Hatton T. A. Rigid, superparamagnetic chains of permanently linked beads coated with magnetic nanoparticles.synthesis and rotational dynamics under applied magnetic fields, Langmuir,2005,21(24): 11500-11509.
[33].安丽娟,李兆强,王燕萍,等.超顺磁性高分子微球的制备与表征高等学校化学学报,2006,27(7)：1372-1375.
[34]. Shan G. B., Xing J. M., Luo M. F., et al. Immobilization of Pseudomonas delafieldii with magnetic polyvinyl alcohol beads and its application in biodesulfurization, Biotechnol. Lett.,2003,25(23):1977-1981.
[35]. Stephane Mornet, Josik Portier, Etienne Duguet, A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran. Journal of Magnetism and Magnetic Materials.2005; 293:127-134.
[36]. R. S. Molday and D. Mackenzie, Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells, J. Immunol. Methods.1982; 52:353-367.
[37]. Kim D. K., Mikhaylova M., Zhang Y, et al. Protective coating of superparamagnetic iron oxide nanoparticles.Chem.Mater.,2003,15(8):1617-1627.
[38]. Kim D. K., Mikhaylova M., Wang F. H., et al. Starch-Coated Superparamagnetic Nanoparticles as MR Contrast Agents, Chem. Mater.,2003, 15(23):4343-4351.
[39]. Olsen D,Yang C,Bodo M,et al.Recombinant collagen and gelatin for drug delivery, Adv. Drug Deliv. Rev.,2003,55(12):1547-1567.
[40]. Bodnar M,Hartmann JF,Borbely J.Preparation and characterization of chitosan-based nanoparticles.Biomacromolecules.2005;6(5):2521-2527.
[41]. Chang YC,Chen DH.Preparation and adsorption properties of monodisperse chitosan-bound Fe3O4 magnetic nanoparticles for removal of Cu(II)ions.J Colloid Interface Sci.2005; 283(2):446-451.
[42]. Burke N. A. D., Stover H. D. H., Dawson F. P., Magnetic Nanocomposites: Preparation and Characterization of Polymer-Coated Iron Nanoparticles Chem. Mater.,2002,14(11):4752-4761.
[43]. B L Frankamp,A K Boal,M T Tuominen,et al.Direct control of the magnetic interaction between iron oxide nanoparticles through dendrimer-mediated self-assembly. J. Am. Chem. Soc.,2005,127(27):9731-9735.
[44]. He H W,Liu H J,Zhou K C,et al.Characteristics of magnetic Fe3O4 nanoparticles encapsulated with human serum albumin. J. Cent. South Univ. T., 2006,13(1):6-11.
[45]. Mikhaylova M,Kim D K,Berry C C,et al.BSA immobilization on amine-functionalized superparamagnetic iron oxide nanoparticles Chem. Mater., 2004,16(12):2344-2354.
[46]. Lewin M,Carlesso N,Tung C-H,et al.Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol.,2000,18(4):410-414.
[47]. D G Georganopoulou,L Chang,Nam J M,et al.Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc. Natl. Acad. Sci. USA,2005,102(7):2273-2276.
[48]. Weizmann Y,Patolsky F,Lioubashevski O,I.Willner,Magneto-mechanical detection of nucleic acids and telomerase activity in cancer cells, J. Am. Chem. Soc.,2004,126(4):1073-1080.
[49]. Zhang Chunfu, Cao Jinquan, Yin Duanzhi, Wang Yongxian, Feng Yanlin, Tan Jiaju, Preparation and radiolabeling of human serum albumin(I)-coated magnetite nanoparticles for magnetically targeted therapy, Applied Radiation and Isotopes 2004; 61:1255-1259.
[50]. L. Wang, J. Bao, L. Wang, F. Zhang, Y. D. Li, One-pot synthesis and bioapplication of amine-functionalized magnetite nanoparticles and hollow nanospheres, Chem. Eur. J.2006,12,6341-6347.
[51]. D. R. Amorin, X. Wang, M. Gaboyard, R. Clerac, S. Nlate, K. Heuze, Dendron-Functionalized Core-Shell Superparamagnetic Nanoparticles: Magnetically Recoverable and Reusable Catalysts For Suzuki C-C Cross-Coupling Reactions, Chem. Eur. J.2009. (In Press)
[52]. Y. Chan, John P. Zimmer, M. Stroh, J. S. Steckel, R. K. Jain, M. G. Bawendi, Incorporation of luminescent nanocrystals into monodisperse Core-Shell silica microspheres, Adv. Mater.2004,16,23-24.
[53]. S. I. Stoeva, F. Huo, J-S Lee, et al. Three-layer composite magnetic nanoparticle probes for DNA, J. Am. Chem. Soc.,2005,127(44):15362-15363.
[54]. P. Wu, J. Zhu, Z. Xu, Template-assisted synthesis of mesoporous magnetic nanocomposite particles, Adv. Funct. Mater.2004,14,345-351.
[55]. W. Zhao, J. Gu, L. Zhang, H. Chen, J. Shi, Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure, J. Am. Chem. Soc,2005,127,8916-8917.
[56]. Y. Deng, D. Qi, C. Deng, X. Zhang, D. Zhao, superparamagnetic high-magnetization microspheres with an Fe3O4@SiO2 core and perpendicularly aligned mesorporous SiO2 shell for removal of microcystins, J. Am. Chem. Soc., 2008,130,28-29.
[57]. M. Shokouhimehr, Y. Piao, J. Kim, Y. Jang, T. Hyeon, a magnetically recyclable nanocomposite catalyst for olefin epoxidation, J. Am. Chem. Soc., 2007,46,7039-7043.
[58]. A. J. Rosengart, M. D. Kaminski, H. Chen, P. L. Caviness, A. D. Ebner, J. A. Ritter, Magnetizable implants and functionalized magnetic carriers:A novel approach for noninvasive yet targeted drug delivery, J. Magn. Magn. Mater.,2005, 293,633-638.
[59]. X. Q. Xu, C. H. Deng, M. X. Gao, W. J. Yu, P. Y. Yang, X. G. Zhang, Synthesis of Magnetic Microspheres with Immobilizated Metal Ions for Enrichment and Direct Determination of Phosphopeptides by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry, Adv. Mater.2006,18, 3289-3293.
[60]. C. J Tan, H. G. Chua, K. H. Ker, Y. W. Tong, Preparation of Bovine Serum Albumin Surface-Imprinted Submicrometer Particles with Magnetic Susceptibility through Core-Shell Miniemulsion Polymerization, Anal. Chem., 2008,80,683-692.
[61]. L. Wang, J. Bao, L. Wang, F. Zhang, Y. Li, One-Pot Synthesis and Bioapplication of Amine-Functionlized Magnetite Nanoparticles and Hollow Nanospheres, Chem. Eur. J.2006,12,6341-6347.
[62]. Y. Sun, Y. Xia, Science,2002,298,2176-2179
[63]. Y L. Wang, Y. N. Xia, Nano. Lett.,2004,4,2047-2050.
[64]. G. Viau, R. Brayner, L. Poul, N. Chakroune, E. Lacaze, F. Fievet-Vincent, Chem. Mater.,2003,15,486-494.
[65]. K. R. Brown, D. G. Walter, M. J. Natan, Chem. Mater.2000,12,306-313.
[66]. X. Q. Xu, C. H. Deng, M. X. Gao, W. J. Yu, P. Y. Yang, X. M. Zhang, Adv. Mater.,2006,18,3289-3291.
[67]. Templated-Assisted Synthesis of Mesoporous Magnetic Nanocomposite Particles, P. Wu, J. Zhu, Zh. Xu, Adv. Funct. Mater.,2004,14,345-351.
[68]. Fabrication of Uniform Magnetic Nanocomposite Spheres with a Magnetic Core/Mesoporous Silica Shell Structure, W. Zhao, J. Gu, L. Zhang, H. Chen, J. Shi, J. Am. Chem. Soc.,2005,127,8916-8917.
[69]. Superparamagnetic High-Magnetization Microspheres with an Fe3O4@SiO2 Core and Perpendicularly Aligned Mesoporous SiO2 Shell for Removal of Microcystins, Y.H. Deng, D.W. Qi, C.H. Deng, X.M. Zhang, D.Y. Zhao, J. Am. Chem. Soc.,2008,130,28-29.