老年性骨质疏松血瘀病机的宏观论证
|
摘要
目的：
通过对老年性骨质疏松患者“血瘀”表现的宏观指标观察和分析,论证老年性骨质疏松症存在血瘀的改变,为运用活血通络法治疗老年性骨质疏松提供理论基础。方法：
对30例老年性骨质疏松症患者、30例老年性低骨量进行“血瘀”临床表现综合评分和甲皱微循环评分,并进行血液流变学检测,同时检测30例健康成年人作为正常值对照,并将血瘀综合评分与甲皱微循环评分、血液流变学检测和骨密度进行相关系数分析。
结果：
1.老年性骨质疏松症患者组、老年性低骨量组、健康成年人组间的骨密度有非常显著性差异(P<0.01),表明老年性骨质疏松的骨密度明显低于青壮年,老年同龄之间亦有非常显著性差异。
2.老年性骨质疏松症患者组“血瘀”临床表现评分与健康成年人组比较,有非常显著性差异(P<0.01)；老年性低骨量组“血瘀”临床表现评分与健康成年人组比较,有非常显著性差异(P<0.01)；老年性骨质疏松症患者组“血瘀”临床表现评分与老年性低骨量组比较,有显著性差异(P<0.05),表明老年性骨质疏松患者有痛有定处、舌下脉络曲张、舌质紫暗有瘀斑、口唇暗红皮肤粘膜瘀斑等血瘀证的表现,其“血瘀”临床表现评分与老年性骨质疏松程度呈正相关性。
3.老年性骨质疏松症患者组甲皱微循环综合评分与健康成年人组比较,有非常显著性差异(P<0.01)；老年性低骨量组甲皱微循环综合评分与健康成年人组比较,有显著性差异(P<0.05)；老年性骨质疏松症患者组甲皱微循环综合评分与老年性低骨量组比较,有非常显著性差异(P<0.01),表明老年人骨质疏松患者的甲皱微循环综合评分与老年性骨质疏松程度呈正相关性。
4.老年性骨质疏松症患者组血液流变学各项指标与健康成年人组比较,有非常显著性差异(P<0.01)；老年性低骨量组血液流变学各项指标与健康成年人组比较,有显著性差异(P<0.05)；老年性骨质疏松症患者组血液流变学各项指标与老年性低骨量组比较,有非常显著性差异(P<0.01)或显著性差异(P<0.05),表明老年性骨质疏松患者存在血液流变学变化,其血液流变学各项指标与老年性骨质疏松程度呈正相关性。
结论：
1.老年性骨质疏松症属中医“骨痿”、“骨痹”范畴,是伴随人体的衰老而发生的疾病,老年性骨质疏松症患者由于其生理病理过程的原因,血瘀在其发病有着重要作用。
2.老年性骨质疏松症患者均存在着痛有定处、舌下脉络曲张、舌质紫暗有瘀斑、口唇暗红皮肤粘膜瘀斑等血瘀证的表现,血瘀的程度与其股骨近端骨密度、甲皱微循环综合评分、血液流变学变化的变化有密切相关。
3.老年人骨质疏松程度与其血瘀程度呈正相关性,表明血瘀是老年性骨质疏松症发病的一个病机。
Objective:
Based on osteoporosis patients'blood stasis "performance index of the macroscopic observation and analysis, senile osteoporosis, blood stasis exists for blood to change by method of treating senile osteoporosis, providing theoretical basis.
Methods:
On 30 cases senile osteoporosis,30 cases of patients with low density for "blood stasis" clinical manifestations of integrated assessment and wrinkly to knit, microcirculation and hemorheology detection, and testing of 30 cases as normal, healthy adults and blood stasis comprehensive evaluation and wrinkly to knit microcirculation score, hemorheology detection and analysis of related coefficient of bone.
Results:
1. Senile osteoporosis patients, senile low bone mass, healthy adults between the bone has a very significant difference (P<0.01),show the bone osteoporosis obviously lower than older age between youths, also have very significant difference.
2.Senile osteoporosis patients'clinical performance rating and blood stasis "group compared with healthy adults, have very significant difference (P<0.01), Senile low bone mass groups "blood stasis" clinical performance rating group compared with healthy adults, have very significant difference (P<0.01),Senile osteoporosis patients'clinical performance rating and blood stasis"low bone mass groups with alzheimer's, have significant difference (P<0.05) that osteoporosis patients have a pain, varicose vein under the tongue is dark purple tongue, bruises, oral mucosa as dark skin bruises of blood stasis, its" blood stasis "clinical performance rating and osteoporosis degree of parturients.
3.Senile osteoporosis patients wrinkly to knit microcirculation comprehensive rating group compared with healthy adults, have very significant difference (P<0.01), Senile low bone mass groups with comprehensive rating wrinkly to knit microcirculation, healthy adults group compared with significant difference (P<0.05). Senile osteoporosis patients with comprehensive rating wrinkly to knit microcirculation low bone mass groups, amd is very significant difference (P<0.01), the elderly patients with osteoporosis microcirculation comprehensive pointrating wrinkly to knit with osteoporosis degree of parturients.
4. Senile osteoporosis patients hemorheology indices and healthy adults, have very significant group compared difference (P<0.01), Senile low bone mass groups with hemorheology indices, healthy adults group compared with significant difference (P< 0.05). Senile osteoporosis patients hemorheology indices and senile low bone mass groups have very significant difference (P<0.01)or significant difference (P<0.05) that osteoporosis patients exist the hemorrheologic changes of blood rheology and the index and osteoporosis degree of parturients.
Conclusion:
1.Senile osteoporosis belong to TCM bones paralysis","GuBi" category, is associated with human aging and disease, senile osteoporosis patients because of its physiological pathology process, blood stasis on its incidence plays an important role.
2.Senile osteoporosis patients have existed for varicose vein, under the tongue, tongue are dark purple lips bruises, dark skin bruises mucosal blood stasis etc, blood stasis degree and proximal femoral BMD,wrinkly to knit microcirculation comprehensive rating, the hemorrheologic changes are closely related to the change.
3.People with osteoporosis degree of blood stasis degree of parturients, blood stasis is that the pathogenesis of senile osteoporosis, a pathogenesis.
通过对老年性骨质疏松患者“血瘀”表现的宏观指标观察和分析,论证老年性骨质疏松症存在血瘀的改变,为运用活血通络法治疗老年性骨质疏松提供理论基础。方法：
对30例老年性骨质疏松症患者、30例老年性低骨量进行“血瘀”临床表现综合评分和甲皱微循环评分,并进行血液流变学检测,同时检测30例健康成年人作为正常值对照,并将血瘀综合评分与甲皱微循环评分、血液流变学检测和骨密度进行相关系数分析。
结果：
1.老年性骨质疏松症患者组、老年性低骨量组、健康成年人组间的骨密度有非常显著性差异(P<0.01),表明老年性骨质疏松的骨密度明显低于青壮年,老年同龄之间亦有非常显著性差异。
2.老年性骨质疏松症患者组“血瘀”临床表现评分与健康成年人组比较,有非常显著性差异(P<0.01)；老年性低骨量组“血瘀”临床表现评分与健康成年人组比较,有非常显著性差异(P<0.01)；老年性骨质疏松症患者组“血瘀”临床表现评分与老年性低骨量组比较,有显著性差异(P<0.05),表明老年性骨质疏松患者有痛有定处、舌下脉络曲张、舌质紫暗有瘀斑、口唇暗红皮肤粘膜瘀斑等血瘀证的表现,其“血瘀”临床表现评分与老年性骨质疏松程度呈正相关性。
3.老年性骨质疏松症患者组甲皱微循环综合评分与健康成年人组比较,有非常显著性差异(P<0.01)；老年性低骨量组甲皱微循环综合评分与健康成年人组比较,有显著性差异(P<0.05)；老年性骨质疏松症患者组甲皱微循环综合评分与老年性低骨量组比较,有非常显著性差异(P<0.01),表明老年人骨质疏松患者的甲皱微循环综合评分与老年性骨质疏松程度呈正相关性。
4.老年性骨质疏松症患者组血液流变学各项指标与健康成年人组比较,有非常显著性差异(P<0.01)；老年性低骨量组血液流变学各项指标与健康成年人组比较,有显著性差异(P<0.05)；老年性骨质疏松症患者组血液流变学各项指标与老年性低骨量组比较,有非常显著性差异(P<0.01)或显著性差异(P<0.05),表明老年性骨质疏松患者存在血液流变学变化,其血液流变学各项指标与老年性骨质疏松程度呈正相关性。
结论：
1.老年性骨质疏松症属中医“骨痿”、“骨痹”范畴,是伴随人体的衰老而发生的疾病,老年性骨质疏松症患者由于其生理病理过程的原因,血瘀在其发病有着重要作用。
2.老年性骨质疏松症患者均存在着痛有定处、舌下脉络曲张、舌质紫暗有瘀斑、口唇暗红皮肤粘膜瘀斑等血瘀证的表现,血瘀的程度与其股骨近端骨密度、甲皱微循环综合评分、血液流变学变化的变化有密切相关。
3.老年人骨质疏松程度与其血瘀程度呈正相关性,表明血瘀是老年性骨质疏松症发病的一个病机。
Objective:
Based on osteoporosis patients'blood stasis "performance index of the macroscopic observation and analysis, senile osteoporosis, blood stasis exists for blood to change by method of treating senile osteoporosis, providing theoretical basis.
Methods:
On 30 cases senile osteoporosis,30 cases of patients with low density for "blood stasis" clinical manifestations of integrated assessment and wrinkly to knit, microcirculation and hemorheology detection, and testing of 30 cases as normal, healthy adults and blood stasis comprehensive evaluation and wrinkly to knit microcirculation score, hemorheology detection and analysis of related coefficient of bone.
Results:
1. Senile osteoporosis patients, senile low bone mass, healthy adults between the bone has a very significant difference (P<0.01),show the bone osteoporosis obviously lower than older age between youths, also have very significant difference.
2.Senile osteoporosis patients'clinical performance rating and blood stasis "group compared with healthy adults, have very significant difference (P<0.01), Senile low bone mass groups "blood stasis" clinical performance rating group compared with healthy adults, have very significant difference (P<0.01),Senile osteoporosis patients'clinical performance rating and blood stasis"low bone mass groups with alzheimer's, have significant difference (P<0.05) that osteoporosis patients have a pain, varicose vein under the tongue is dark purple tongue, bruises, oral mucosa as dark skin bruises of blood stasis, its" blood stasis "clinical performance rating and osteoporosis degree of parturients.
3.Senile osteoporosis patients wrinkly to knit microcirculation comprehensive rating group compared with healthy adults, have very significant difference (P<0.01), Senile low bone mass groups with comprehensive rating wrinkly to knit microcirculation, healthy adults group compared with significant difference (P<0.05). Senile osteoporosis patients with comprehensive rating wrinkly to knit microcirculation low bone mass groups, amd is very significant difference (P<0.01), the elderly patients with osteoporosis microcirculation comprehensive pointrating wrinkly to knit with osteoporosis degree of parturients.
4. Senile osteoporosis patients hemorheology indices and healthy adults, have very significant group compared difference (P<0.01), Senile low bone mass groups with hemorheology indices, healthy adults group compared with significant difference (P< 0.05). Senile osteoporosis patients hemorheology indices and senile low bone mass groups have very significant difference (P<0.01)or significant difference (P<0.05) that osteoporosis patients exist the hemorrheologic changes of blood rheology and the index and osteoporosis degree of parturients.
Conclusion:
1.Senile osteoporosis belong to TCM bones paralysis","GuBi" category, is associated with human aging and disease, senile osteoporosis patients because of its physiological pathology process, blood stasis on its incidence plays an important role.
2.Senile osteoporosis patients have existed for varicose vein, under the tongue, tongue are dark purple lips bruises, dark skin bruises mucosal blood stasis etc, blood stasis degree and proximal femoral BMD,wrinkly to knit microcirculation comprehensive rating, the hemorrheologic changes are closely related to the change.
3.People with osteoporosis degree of blood stasis degree of parturients, blood stasis is that the pathogenesis of senile osteoporosis, a pathogenesis.
引文
[1]刘忠厚,杨定焯.中国人骨质疏松症建议诊断标准(第二稿)[J].中国骨质疏松杂志,2000,6(1)：2
[2]Cooper C. Epidemiology and public health impact of osteoporosis[J]. Baillieres. Clin Rheumatol,1993,7(3):459-77
[3]De Laet CE, Pols HA. Fractures in the elderly[J]:epidemiology and demography. Baillieres Best. Pract Res Clin Endocrinol Metab.2000,14 (2):171-9
[4]Torring O. Osteoporosis among the elderly is a "silent epidemics"[J]. Insufficient prophylaxis and underdiagnosing are big problems. Lakartidningen,2001,14(28-29):3220-3224
[5]赵冀伟.骨质疏松药物治疗概况[J].天津药学,2004,16(2)：683-684
[6]周文泉,于向东.骨质疏松症的中医及中西医结合研究评述[J].中国临床康复,2002,18(6)：2768-2769
[7]刘庆思.中西医结合诊治骨质疏松症[M].北京：中国中医药出版社,2001,第一版,3
[8]Meumie-HE. Predictions on future diagnosis and treatment of osteoporosis[J]. Calcif-Tissue-Int.1995,57(2):83
[9]第二届全国活血化瘀研究学术会议修订.血瘀证诊断标准[J].中西医结合杂志,1987,7(3)：129
[10]王宁华.疼痛定量评定的进展[J].中国临床康复,2002,6(18)：2738-2739
[11]周丕琪,沈霖,杜靖远,等.PMOP与血清IL-6, TNF-α浓度关系的临床研究[J].中国骨质疏松杂志,2001,7(1)：1-3,8
[12]田牛.实用临床微循环学[M].军事科学出版社,北京,1989,第一版,28-31
[13]刘钫,刘和娣,李恩.肾虚与骨质疏松及补肾中药的作用[J].中国骨质疏松杂志,2000,6(4)：83
[14]张继东,郭福新.陈忠强对衰老机理的认识[J]. 山东中医杂志,1992,11(6)：45
[15]薛红丽.补肾活血抗自由基损伤延缓衰老的研究进展[J].实用老年医学,1999,13(1)：34-35
[16]赵玉堂,刘凯军,李金花,等.骨矿含量与肾虚、肾主骨关系的研究[J].中国骨质疏松杂志,1996,2(3)：19
[17]李边达.中药治疗无茵性股骨头坏死及骨质疏松症的主要药效学研究技本要求[J].中药新药与临床,1992,3(2)：7
[18]朱凌凌,童瑶,陈慧娟,等.脾的中西医学比较研究[J].浙江中医杂 志,2006,41(1)：1-6
[19]王阶,姚魁武.血瘀证证候实质研究进展与思考[J].中国医药学报,2003,18(8)：490-493
[20]刘毅波.血瘀证的病理及活血化瘀中药的临床应用[J].天津中医药,2008,25(3)：246-249
[21]郭郡浩,蔡辉.从瘀论治原发性骨质疏松症研究进展[J].河北中医,2008,30(11)：1225-1227
[22]谢林,姚共和,郭振球.健脾养胃法治疗骨质疏松症初探[J].湖南中医学院学报[J],1996,16(4)：7-9
[23]陈中冀,史载祥.实用血瘀证学[M].北京：人民卫生出版杜,1999.28
[24]田牛,微循环学[M].北京：原子能出版社,2004.26-27
[25]陈建钢,吴小燕,李辉.血瘀证与老年舌微循环障碍[J].现代口腔医学杂志,2001,15(2)：109
[26]李爱萍,吴立红,罗,峰,徐晓峰.体检人群甲襞微循环检测结果分析[J].微循环学杂志,2008,18(2)：49-50,54
[27]眭承志,周军,刘志坤.绝经后骨质疏松症血瘀病机的客观初步论证[J].中医研究[J],2005,18(1)：30-34
[28]何成奇.骨质疏松症的康复治疗技术[M].北京：北京人民出版社,2008.87
[29]Pederson L, Kremer M, Judd J, et al. Androgen regulate bone re-sorption activity of isolated osteoblasts in vitro. Proc Nat Acad Sci USA[J],1999,96:505-510
[30]张大宁,多秀瀛,张免之,王之贤.肾阳虚与血瘀关系的实验研究[J].中国中医药信息杂志,2006,1(13)：26-27
[31]李鸥,樊贵玲.绝经前子宫切除术后雌激素及微循环的变化[J].中国煤炭工业医学杂志.2002,2,5(2)：151-152
[32]郭世绂,罗先正,邱贵兴.骨质疏松基础与临床[M].天津：天津科学技术出版,2001.188
[33]陈利国,孙兆贵,王蕾,等.血瘀证与血管内皮细胞内游离钙浓度关系的实验研究[J].山东中医药大学学报[J],2001,25(1)：55
[34]Uchio Y, Ochi N, et al. Intraosseous hypertension and venous congestion in osteonecrosis of the knee.Clin Orthop[J].2001,384(3):217-223
[35]马克昌,冯坤,朱太咏,等.骨生理学[M].郑州：河南医科大学出版社,2000,515-516
[36]喻晶,余学峰.骨代谢标志物和骨矿密度在骨质疏松症中的应用[J].临床内科杂志,2009,26(17)：29-31.
[37]王阶,姚魁武.血瘀证证候实质研究进展与思考[J].中国医药学报,2003,18(8)：490-493
[38]郑瑞璋,吴若銮,陈一鸣.心脑宁胶囊抗栓作用血流变的实验与临床研究[J].新中医,1997,29(2)：32-34
[39]魏艾红,白血病舌质及血瘀病理研究[J].中国医药学报,1995,10(5)：11
[40]田牛.微循环的临床与基础[M].北京：原子能出版社,1996,第一版,3
[41]翁维良.临床常用血液流变学指标的含义与评价(一)[J].微循环学杂志,1994,4(1)：43
[42]杨少锋.关子骨质疏松症与血瘀关系的探讨[J].湖南中医药导报,1996,2(4)：25-26
[1]Torring 0. Osteoporosis among the elderly is a "silent epidemics". Insufficient prophylaxis and underdiagnosing are big problems. Lakarti dningen[J],2001,14(28-29):32
[2]张华,朱洪民,宁显明.原发性骨质疏松症病因病机探析[J].国医论坛,2001,16(2)：24-25
[3]刘庆思.中西医结合诊治骨质疏松症[M].北京：中国中医药出版社,2001：73-83
[4]谢林,姚共和,郭振球.健脾养胃法治疗骨质疏松症初探[J].湖南中医学院学报,1996,16(4)：7-9
[5]陈可冀史载祥.实用血瘀证学[M].北京：人民卫生出版杜,1999：28
[6]田牛.微循环方法学[M].北京：原子能出版社,2004：26-27
[7]陈建钢,吴小燕,李辉奉.血瘀证与老年舌微循环障碍[J].现代口腔医学杂志,2001,15(2)：108-109
[8]李爱萍,吴立红,罗峰,等.体检人群甲襞微循环检测结果分析[J].微循环学杂志,2008,18(2)：49-50,54
[9]眭承志,周军,刘志坤.绝经后骨质疏松症血瘀病机的客观初步论证[J].中医研究,2005,18(1)：30-33
[10]何成奇.骨质疏松症的康复治疗技术[M].北京：北京人民出版社,2008：87
[11]Pederson L, Kremer M, Judd J, et al. Androgens regulate bone resorption activity of isolated osteoclasts in vitro [J]. Proc Natl Acad Sci U S A,1999, 96(2):505-510.
[12]Kasperk C,Helmboldt A, Borcsok I, et al. Skeletal site-dependent expression of the androgen receptor in human osteoblastic cell population. Calcif Tissue Int[J],1997,61:464-433
[13]张大宁,多秀瀛,张勉之,等.肾阳虚与血瘀关系的实验研究[J].中国中医药信息杂志,2006,13(1)：26-28
[14]Sasano H, Uzuki M, Sawai T, et al.Aromatase in human bone tissue.Bone Miner Res[J],1997,12:1416-1423
[15]李鸥,樊桂玲.绝经前子宫切除术后雌激素及微循环的变化[J].中国煤炭工业医学杂志,2002,5(2)：151-152.
[16]郭世绂,罗先正,邱贵兴.骨质疏松基础与临床[M].天津：天津科学技术出版社,2001：188
[17]陈利国,孙兆贵,王蕾,等.血瘀证与血管内皮细胞内游离钙浓度关系的实验研究[J].山东中医药大学学报,2001,25(1)：55-57
[18]Uchio Y,Ochi M, Adachi N, et al. Intraosseous hypertension and venous congestion in osteonecrosis of the knee[J].Clin Orthop Relat Res,2001, (384):217-223
[19]马克昌,冯坤,朱太咏,等.骨生理学[M].郑州：河南医科大学出版社,2000：515-516
[2]Cooper C. Epidemiology and public health impact of osteoporosis[J]. Baillieres. Clin Rheumatol,1993,7(3):459-77
[3]De Laet CE, Pols HA. Fractures in the elderly[J]:epidemiology and demography. Baillieres Best. Pract Res Clin Endocrinol Metab.2000,14 (2):171-9
[4]Torring O. Osteoporosis among the elderly is a "silent epidemics"[J]. Insufficient prophylaxis and underdiagnosing are big problems. Lakartidningen,2001,14(28-29):3220-3224
[5]赵冀伟.骨质疏松药物治疗概况[J].天津药学,2004,16(2)：683-684
[6]周文泉,于向东.骨质疏松症的中医及中西医结合研究评述[J].中国临床康复,2002,18(6)：2768-2769
[7]刘庆思.中西医结合诊治骨质疏松症[M].北京：中国中医药出版社,2001,第一版,3
[8]Meumie-HE. Predictions on future diagnosis and treatment of osteoporosis[J]. Calcif-Tissue-Int.1995,57(2):83
[9]第二届全国活血化瘀研究学术会议修订.血瘀证诊断标准[J].中西医结合杂志,1987,7(3)：129
[10]王宁华.疼痛定量评定的进展[J].中国临床康复,2002,6(18)：2738-2739
[11]周丕琪,沈霖,杜靖远,等.PMOP与血清IL-6, TNF-α浓度关系的临床研究[J].中国骨质疏松杂志,2001,7(1)：1-3,8
[12]田牛.实用临床微循环学[M].军事科学出版社,北京,1989,第一版,28-31
[13]刘钫,刘和娣,李恩.肾虚与骨质疏松及补肾中药的作用[J].中国骨质疏松杂志,2000,6(4)：83
[14]张继东,郭福新.陈忠强对衰老机理的认识[J]. 山东中医杂志,1992,11(6)：45
[15]薛红丽.补肾活血抗自由基损伤延缓衰老的研究进展[J].实用老年医学,1999,13(1)：34-35
[16]赵玉堂,刘凯军,李金花,等.骨矿含量与肾虚、肾主骨关系的研究[J].中国骨质疏松杂志,1996,2(3)：19
[17]李边达.中药治疗无茵性股骨头坏死及骨质疏松症的主要药效学研究技本要求[J].中药新药与临床,1992,3(2)：7
[18]朱凌凌,童瑶,陈慧娟,等.脾的中西医学比较研究[J].浙江中医杂 志,2006,41(1)：1-6
[19]王阶,姚魁武.血瘀证证候实质研究进展与思考[J].中国医药学报,2003,18(8)：490-493
[20]刘毅波.血瘀证的病理及活血化瘀中药的临床应用[J].天津中医药,2008,25(3)：246-249
[21]郭郡浩,蔡辉.从瘀论治原发性骨质疏松症研究进展[J].河北中医,2008,30(11)：1225-1227
[22]谢林,姚共和,郭振球.健脾养胃法治疗骨质疏松症初探[J].湖南中医学院学报[J],1996,16(4)：7-9
[23]陈中冀,史载祥.实用血瘀证学[M].北京：人民卫生出版杜,1999.28
[24]田牛,微循环学[M].北京：原子能出版社,2004.26-27
[25]陈建钢,吴小燕,李辉.血瘀证与老年舌微循环障碍[J].现代口腔医学杂志,2001,15(2)：109
[26]李爱萍,吴立红,罗,峰,徐晓峰.体检人群甲襞微循环检测结果分析[J].微循环学杂志,2008,18(2)：49-50,54
[27]眭承志,周军,刘志坤.绝经后骨质疏松症血瘀病机的客观初步论证[J].中医研究[J],2005,18(1)：30-34
[28]何成奇.骨质疏松症的康复治疗技术[M].北京：北京人民出版社,2008.87
[29]Pederson L, Kremer M, Judd J, et al. Androgen regulate bone re-sorption activity of isolated osteoblasts in vitro. Proc Nat Acad Sci USA[J],1999,96:505-510
[30]张大宁,多秀瀛,张免之,王之贤.肾阳虚与血瘀关系的实验研究[J].中国中医药信息杂志,2006,1(13)：26-27
[31]李鸥,樊贵玲.绝经前子宫切除术后雌激素及微循环的变化[J].中国煤炭工业医学杂志.2002,2,5(2)：151-152
[32]郭世绂,罗先正,邱贵兴.骨质疏松基础与临床[M].天津：天津科学技术出版,2001.188
[33]陈利国,孙兆贵,王蕾,等.血瘀证与血管内皮细胞内游离钙浓度关系的实验研究[J].山东中医药大学学报[J],2001,25(1)：55
[34]Uchio Y, Ochi N, et al. Intraosseous hypertension and venous congestion in osteonecrosis of the knee.Clin Orthop[J].2001,384(3):217-223
[35]马克昌,冯坤,朱太咏,等.骨生理学[M].郑州：河南医科大学出版社,2000,515-516
[36]喻晶,余学峰.骨代谢标志物和骨矿密度在骨质疏松症中的应用[J].临床内科杂志,2009,26(17)：29-31.
[37]王阶,姚魁武.血瘀证证候实质研究进展与思考[J].中国医药学报,2003,18(8)：490-493
[38]郑瑞璋,吴若銮,陈一鸣.心脑宁胶囊抗栓作用血流变的实验与临床研究[J].新中医,1997,29(2)：32-34
[39]魏艾红,白血病舌质及血瘀病理研究[J].中国医药学报,1995,10(5)：11
[40]田牛.微循环的临床与基础[M].北京：原子能出版社,1996,第一版,3
[41]翁维良.临床常用血液流变学指标的含义与评价(一)[J].微循环学杂志,1994,4(1)：43
[42]杨少锋.关子骨质疏松症与血瘀关系的探讨[J].湖南中医药导报,1996,2(4)：25-26
[1]Torring 0. Osteoporosis among the elderly is a "silent epidemics". Insufficient prophylaxis and underdiagnosing are big problems. Lakarti dningen[J],2001,14(28-29):32
[2]张华,朱洪民,宁显明.原发性骨质疏松症病因病机探析[J].国医论坛,2001,16(2)：24-25
[3]刘庆思.中西医结合诊治骨质疏松症[M].北京：中国中医药出版社,2001：73-83
[4]谢林,姚共和,郭振球.健脾养胃法治疗骨质疏松症初探[J].湖南中医学院学报,1996,16(4)：7-9
[5]陈可冀史载祥.实用血瘀证学[M].北京：人民卫生出版杜,1999：28
[6]田牛.微循环方法学[M].北京：原子能出版社,2004：26-27
[7]陈建钢,吴小燕,李辉奉.血瘀证与老年舌微循环障碍[J].现代口腔医学杂志,2001,15(2)：108-109
[8]李爱萍,吴立红,罗峰,等.体检人群甲襞微循环检测结果分析[J].微循环学杂志,2008,18(2)：49-50,54
[9]眭承志,周军,刘志坤.绝经后骨质疏松症血瘀病机的客观初步论证[J].中医研究,2005,18(1)：30-33
[10]何成奇.骨质疏松症的康复治疗技术[M].北京：北京人民出版社,2008：87
[11]Pederson L, Kremer M, Judd J, et al. Androgens regulate bone resorption activity of isolated osteoclasts in vitro [J]. Proc Natl Acad Sci U S A,1999, 96(2):505-510.
[12]Kasperk C,Helmboldt A, Borcsok I, et al. Skeletal site-dependent expression of the androgen receptor in human osteoblastic cell population. Calcif Tissue Int[J],1997,61:464-433
[13]张大宁,多秀瀛,张勉之,等.肾阳虚与血瘀关系的实验研究[J].中国中医药信息杂志,2006,13(1)：26-28
[14]Sasano H, Uzuki M, Sawai T, et al.Aromatase in human bone tissue.Bone Miner Res[J],1997,12:1416-1423
[15]李鸥,樊桂玲.绝经前子宫切除术后雌激素及微循环的变化[J].中国煤炭工业医学杂志,2002,5(2)：151-152.
[16]郭世绂,罗先正,邱贵兴.骨质疏松基础与临床[M].天津：天津科学技术出版社,2001：188
[17]陈利国,孙兆贵,王蕾,等.血瘀证与血管内皮细胞内游离钙浓度关系的实验研究[J].山东中医药大学学报,2001,25(1)：55-57
[18]Uchio Y,Ochi M, Adachi N, et al. Intraosseous hypertension and venous congestion in osteonecrosis of the knee[J].Clin Orthop Relat Res,2001, (384):217-223
[19]马克昌,冯坤,朱太咏,等.骨生理学[M].郑州：河南医科大学出版社,2000：515-516