5'-磷酸腺苷诱导低温治疗急性痛风性关节炎的实验研究
摘要
目的探讨5’-磷酸腺苷(Adenosine 5'-Monophosphate,5'一AMP)诱导的低温对于急性痛风性关节炎的早期炎症反应的抑制作用。
方法通过建立大鼠低温急性痛风性关节炎模型,分别检测大鼠踝关节滑膜组织病理切片,外周血白介素-1β(Interleukin-1β,IL-1β)和基质金属蛋白酶-9(Metall oproteinase-9,MMP-9)的水平以及关节滑膜组织核转录因子KB(Nuclear Factor-κappaB,NF-κB)通路的激活情况,来观察5’AMP是否能有效地抑制急性痛风性关节炎大鼠早期的炎症反应。结果5’-AMP诱导的低温能够有效地抑制急性痛风性关节炎早期的炎症反应。其作用表现在以下方面：1)大鼠踝关节肿胀度的明显减轻(p<0.001)；2)大鼠踝关节滑膜组织的炎症细胞浸润、水肿、充血的明显减轻；3)外周血IL-1β(p<0.001)和MMP-9(p<0.001)水平的显著降低；4)关节滑膜组织NF-KB活性的显著抑制(p<0.001)。
结论5’-AMP诱导的低温可以通过抑制NF-KB通路来抑制急性痛风性关节炎大鼠早期的炎症反应,为以后临床的治疗提供了理论和实验室依据。
Objectives:To investigate the effect of the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) on gouty arthritis.
Methods:Ankle joint injection with monosodium urate monohydrate (MSU) crystals in hypothermia rats model which was induced by 5'-AMP, and then observe the effect of hypothermia induced by 5'-AMP on acute gouty arthritis via detecting the swelling of rat ankle, serum level of Interleukin-1β(IL-1β) and metalloproteinase-9 (MMP-9), the synovium tissue of rat ankle and the Nuclear Factor-KappaB (NF-κB) activity.
Results:The hypothermia induced by 5'-AMP has protective effects on acute gouty arthritis, which was demonstrated by the following criteria:1) a significant reduction of the ankle swelling (p<0.001); 2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; and 3) a significant reduction in the presence of IL-1β(p<0.001) and MMP-9 (p<0.001).4) a significant inhibition in the Nuclear Factor-κappaB (NF-κB) activity (p<0.001).
Conclusions:Hypothermia induced by 5'-AMP could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.
方法通过建立大鼠低温急性痛风性关节炎模型,分别检测大鼠踝关节滑膜组织病理切片,外周血白介素-1β(Interleukin-1β,IL-1β)和基质金属蛋白酶-9(Metall oproteinase-9,MMP-9)的水平以及关节滑膜组织核转录因子KB(Nuclear Factor-κappaB,NF-κB)通路的激活情况,来观察5’AMP是否能有效地抑制急性痛风性关节炎大鼠早期的炎症反应。结果5’-AMP诱导的低温能够有效地抑制急性痛风性关节炎早期的炎症反应。其作用表现在以下方面：1)大鼠踝关节肿胀度的明显减轻(p<0.001)；2)大鼠踝关节滑膜组织的炎症细胞浸润、水肿、充血的明显减轻；3)外周血IL-1β(p<0.001)和MMP-9(p<0.001)水平的显著降低；4)关节滑膜组织NF-KB活性的显著抑制(p<0.001)。
结论5’-AMP诱导的低温可以通过抑制NF-KB通路来抑制急性痛风性关节炎大鼠早期的炎症反应,为以后临床的治疗提供了理论和实验室依据。
Objectives:To investigate the effect of the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) on gouty arthritis.
Methods:Ankle joint injection with monosodium urate monohydrate (MSU) crystals in hypothermia rats model which was induced by 5'-AMP, and then observe the effect of hypothermia induced by 5'-AMP on acute gouty arthritis via detecting the swelling of rat ankle, serum level of Interleukin-1β(IL-1β) and metalloproteinase-9 (MMP-9), the synovium tissue of rat ankle and the Nuclear Factor-KappaB (NF-κB) activity.
Results:The hypothermia induced by 5'-AMP has protective effects on acute gouty arthritis, which was demonstrated by the following criteria:1) a significant reduction of the ankle swelling (p<0.001); 2) a significant decrease in the occurrence of leukocyte infiltration and mild hemorrhage; and 3) a significant reduction in the presence of IL-1β(p<0.001) and MMP-9 (p<0.001).4) a significant inhibition in the Nuclear Factor-κappaB (NF-κB) activity (p<0.001).
Conclusions:Hypothermia induced by 5'-AMP could inhibit acute inflammation reaction and protect the synovial tissue against acute injury in a rat acute gouty arthritis model.
引文
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