六味能消胶囊合莫沙比利、达喜治疗胆汁反流性胃炎的临床观察
|
摘要
本课题研究分为理论研究和临床研究两部分。
理论研究部分,对古今医学文献关于本病的诊断认识、病因病机的研究以及近十年来中西医治疗胆汁反流性胃炎的概况进行总结,寻找中医药在治疗中的优势。
临床研究部分,将76例符合研究条件的胆汁反流性胃炎患者按1:1的比例,随机分为六味能消胶囊合达喜、莫沙比利治疗组(41例)与达喜、莫沙必利对照组(35例),经4周治疗,结果治疗组基本治愈3例,显效18例,好转17例,无效2例,总有效率90.47%:对照组分别为0例、13例、17例、5例和85.71%。两组疗效无显著性差异(P＞0.05)。同时,对两组患者的临床症状、胃镜征象、胃黏膜病理学检查及有关实验室指标等变化进行观察,并对胆汁反流胃炎的病因学、证候学进行分析,探讨六味能消胶囊的立法组方特点及疗效机制。通过研究表明:
1.情志因素和吸烟是胆汁反流性胃炎的主要病因,慢性萎缩性胃炎和十二指肠球部溃疡为胃镜下最常见的伴见症,分别为79.00%和21.05%:
2.胆汁反流性胃炎的证候学特点是临床以胃脘痞满(80.26%)、胃脘疼痛(78.95%)、嗳气(75.00%)与口中异味(69.74%)为四大主症,舌质多表现为红或暗红,舌苔黄腻或薄黄,脉多数:
3.本病病机以热邪郁结、胆胃不和、升降失常为要点:
4.清热通下、和胃降气为本病的治疗大法。六味能消胶囊在组方配伍上和、清、泄配合应用,以达和、通、降的目的:
5.六味能消胶囊的疗效机理体现于:(1)改善临床症状,减轻或阻止胆汁反流;
(2)改善胃肠功能,加快胃排空。
This study includes mainly two parts:theoretical research and clinical research.
In the part of the theoretical research. From studying the diagnosis, pathogenic factor and pathogenesis in historical documents of TCM, the author sums up the therapeutic methods of BRG in recent years so as to look for a better way to treat BRG. In the part of clinical research,76 cases of BRG were randomly divided into two groups by 1 to 1.The treatment group (taking capsules of liuweinengxiao and mosapride、Talcid) was 41 cases, and the control group (taking mosapride、Talcid) was 35 cases. The course of treatment was 4 weeks. The results showed that 3 cases were mostly cured, 18 cases were rem- arkably effective, 17 cases were improved,2 cases were ineffective, and the total effective rate was 90.47% in the treatment group. In the control group, there were 0 cases, 13 cases, 17 cases ,5 cases and 85.71% respectively. There was no statistical difference between these two groups (P>0.05). Meanwhile, the author compared the changes of primary symptoms, gastroscope, pathological examination and some related laboratory examination so as to analyze the capsules of liuweinengxiao's mechanism.
The above scientific researches indicate:
1) Smoking and emotion are two main aspects of the causes of BRG.Chronic Atrophic Gastritis and Duodenal ulcer are the main accompanying diseases;
2) The four primary symptoms of semiologicalc haracteristics are : stomachache (78.95%),fullness( 78.95%) ,hiccup(75%)and bitterness in mouth (69.74%). A patient of BRG often shows red or dark red tongue with yellow greasy or thin coating;
3) The chief pathogenesis is disharmony between the gallbladder and stomach, hepatic depression with heat-evil and abnormal ascent and descent;
4) The main treating method is Using Qingre Tongxia and Heweijiangqi.
5) The mechanism of capsules of liuweinengxiao shows as follows: 1)improving clinical symtoms,lessening or resisting bile reflux; 2) promoting the gastric motilily and emptying as well.
理论研究部分,对古今医学文献关于本病的诊断认识、病因病机的研究以及近十年来中西医治疗胆汁反流性胃炎的概况进行总结,寻找中医药在治疗中的优势。
临床研究部分,将76例符合研究条件的胆汁反流性胃炎患者按1:1的比例,随机分为六味能消胶囊合达喜、莫沙比利治疗组(41例)与达喜、莫沙必利对照组(35例),经4周治疗,结果治疗组基本治愈3例,显效18例,好转17例,无效2例,总有效率90.47%:对照组分别为0例、13例、17例、5例和85.71%。两组疗效无显著性差异(P＞0.05)。同时,对两组患者的临床症状、胃镜征象、胃黏膜病理学检查及有关实验室指标等变化进行观察,并对胆汁反流胃炎的病因学、证候学进行分析,探讨六味能消胶囊的立法组方特点及疗效机制。通过研究表明:
1.情志因素和吸烟是胆汁反流性胃炎的主要病因,慢性萎缩性胃炎和十二指肠球部溃疡为胃镜下最常见的伴见症,分别为79.00%和21.05%:
2.胆汁反流性胃炎的证候学特点是临床以胃脘痞满(80.26%)、胃脘疼痛(78.95%)、嗳气(75.00%)与口中异味(69.74%)为四大主症,舌质多表现为红或暗红,舌苔黄腻或薄黄,脉多数:
3.本病病机以热邪郁结、胆胃不和、升降失常为要点:
4.清热通下、和胃降气为本病的治疗大法。六味能消胶囊在组方配伍上和、清、泄配合应用,以达和、通、降的目的:
5.六味能消胶囊的疗效机理体现于:(1)改善临床症状,减轻或阻止胆汁反流;
(2)改善胃肠功能,加快胃排空。
This study includes mainly two parts:theoretical research and clinical research.
In the part of the theoretical research. From studying the diagnosis, pathogenic factor and pathogenesis in historical documents of TCM, the author sums up the therapeutic methods of BRG in recent years so as to look for a better way to treat BRG. In the part of clinical research,76 cases of BRG were randomly divided into two groups by 1 to 1.The treatment group (taking capsules of liuweinengxiao and mosapride、Talcid) was 41 cases, and the control group (taking mosapride、Talcid) was 35 cases. The course of treatment was 4 weeks. The results showed that 3 cases were mostly cured, 18 cases were rem- arkably effective, 17 cases were improved,2 cases were ineffective, and the total effective rate was 90.47% in the treatment group. In the control group, there were 0 cases, 13 cases, 17 cases ,5 cases and 85.71% respectively. There was no statistical difference between these two groups (P>0.05). Meanwhile, the author compared the changes of primary symptoms, gastroscope, pathological examination and some related laboratory examination so as to analyze the capsules of liuweinengxiao's mechanism.
The above scientific researches indicate:
1) Smoking and emotion are two main aspects of the causes of BRG.Chronic Atrophic Gastritis and Duodenal ulcer are the main accompanying diseases;
2) The four primary symptoms of semiologicalc haracteristics are : stomachache (78.95%),fullness( 78.95%) ,hiccup(75%)and bitterness in mouth (69.74%). A patient of BRG often shows red or dark red tongue with yellow greasy or thin coating;
3) The chief pathogenesis is disharmony between the gallbladder and stomach, hepatic depression with heat-evil and abnormal ascent and descent;
4) The main treating method is Using Qingre Tongxia and Heweijiangqi.
5) The mechanism of capsules of liuweinengxiao shows as follows: 1)improving clinical symtoms,lessening or resisting bile reflux; 2) promoting the gastric motilily and emptying as well.
引文
[1].Eriksson B.Duodenogastric bile reflux before and after selective proximal Vagobomy with and without phloroplasty.Scand J Gastroenterol,1990,25(2):161-164.
[2].Borsato N,Bonavina L,Zanco P,et al.Proposal of a modified scintigra-Phic method to evaluate duodenogastro-phageal reflux.J NuclMed,1991,32(3):436-440.
[3].Brown TH,Holbrook I,King RFG,et al.24-hour Zntragastric PH measurement in the assessment of duodenogastric reflux.World Jsurg,1992,16(5):995-999.
[4].Stein HJ,Smyrk TL,Demeester TR,et al.Clinical value of endoscopy and histology in the diagnosis of duodenogastric reflux disease.Surgrery,1992,112(4):796.
[5].Hausken T,Odegaard S,Matre K,et al.Antroduodenal motility and movements of luminal contents studied by duplex sonography.Gastroenterology,1992;102(5):1583-1590.
[6].曾锦章,张万岱,张洪海等.胆汁反流性胃炎诊断标准的探讨.中国实用内科杂志,1997.17:406-408.
[7].叶伯墓.胆汁反流性胃炎证治五法.四川中医,1995,13(10):14-15.
[8].殷凤礼,房长茂.对胆汁反流性胃炎的认识及43例临床治疗观察.中医杂志,1984.25(2):23-26.
[9].王啼星,肖汉玺,岳更山.辫证治疗非手术后胆汁反流性胃炎52例.山西中医,1993.9(1):12.
[10].谷成明,柯美云,朱昭辉,等.胃中间横带在调节糖尿病的胃内食物分布和胃排空.中华内科杂志,1999,38.476-477.
[11].江杨消.胆胃相关与胆汁反流性胃炎的证治.中医杂志,1985,26(4):35-37.
[12].郭建强,柯美云,秦明伟,等.胃中间横带对近端胃和远端胃食物分布的调节作用.中国医学科学报,2000,22(5):416-420.
[13].许国铭.胆汁反流相关性疾病.第一版.上海科学技术出版社,2002:34.
[14].张万岱.曾锦章.胆汁反流性胃炎的胃运动功能研究.胃肠病学,1997(2):71-73.
[15].Testoni PA,Fanti L,Bagnolo F,et al.Manometric evaluation of the interdigestive antroduodenal motility in subjects with fasting bile reflux,with and without antral gastritis.Gut.1989,30:443.
[16].Mirandam,defilippi C,Valenzuela JE.Abnormalities of interdigestive motility coplex and increased duodenogastric reflux in gastric ulcer patients.Dig Dos Sci,1982,30(1):16-21.
[17].Kellosalo J,Alavaikko M,Laitinen S.Effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa.Scand J Gadtrointerol,1991,26(12):1272-1278.
[18].柯美云,谷成明,姜玉新,等.消化不良患者的胃幽门十二指肠运动协调性研究.中国医学科学院报,2000,2(3):240-244.
[19].刘东明,徐肇敏.胆汁反流性胃炎的病因探讨.中华消化内镜杂志,2003,20(1) 51-52.
[20].龚茜玲,钱梓文.生理学.第二版.上海医科大学出版社,1992:116-119.
[21].冯伟华,周岱云,傅敏,等.胃液胆汁酸与黏膜炎症的关系.中华消化杂志,1992,12(2):78.
[22].陈仕珠,赵红,吴春艳,等.胆汁反流性胃炎患者胆囊排空功能研究.华人消化杂志,1998,6 (5):427-428.
[23].陈仕珠,沙建萍,陈旭春,等.胆汁反流性胃炎患者oddi括约肌松弛不良:硝本吡啶改善胆囊排空作用研究,世界华人消化杂志,1999,7(12):1020-1023.
[24].Wilson P,Welch NT,Hinder RA,et al.Abnormal plasma gut hormones in pathologic duodenogastric reflux and theirresponse to surgery.Am J Surg,1993,165(1):169-176.
[25].许国铭.胆汁反流相关性疾病.第一版.上海科学技术出版社.2002:162.
[26].张万岱,曾锦章,彭武和.胆汁反流性胃炎胃排空和促胃液素改变及其意义.解放军医学杂志,1997,22(5):318-320.
[27].陆保林.胆系病变与胆汁反流行胃炎.中国消化病基础与临床,2006,7(5):47-48.
[28].陈濒珠.内科学.第三版.人民卫生出版社,1995:333.
[29].Duane WC.Bile acid and bilt disrupt gastric mucosal barrier in the dog by different mechanis.Am J Physiol,1982,242:95.
[30].Bedi BS,Debas HT,Gillespie G,et al.Effect of bile salts on antralgastr in release.Gastroenterol,1971,60:256-262.
[31].Correa P.Chronic gastritis as a cancer precursor.Stand J Gastroenterol,1984,19(Suppl 104):131 - 136.
[32].张万岱.幽门螺杆菌研究的现状与展望.胃肠病学,1997.2(3):129-130.
[33].朱云华,翟颖,朱海青等.反流性胃炎与HP相关胃炎.内镜,1993.10(3):148-150.
[34].杨晋翔.蓝建华老中医从通降论治胆汁返流性胃炎的经验.新中医,1997.29(1):8-9.
[35].李碧霞.胆汁反流性胃炎150例临床分析.广东医学院学报.1997,2:138-139.
[36].孙绍雄.陈敏清.赵玉芬.胆汁发流性胃炎85例临床分析.实用内科学杂志.1990,10:245.
[37].陈灏珠.李宗明.内科学.第3版.人民卫生出版社.1993.333.
[38].王长洪.通降法治疗胆汁反流性胃炎.云南中医杂志,1984.5(1):7-8.
[39].王群.降逆和胃法治疗胆汁返流性胃炎32例.江苏中医,1993,14(7):18.
[40].黄龙辉.胆胃汤治疗慢性胃炎伴胆汁反流48例疗效观察.中国中西医结合脾胃杂,1997,5(1):46.
[41].郭路南,贾广才.中药治疗胆汁反流性胃炎35例.陕西中医.1991.12(3):108.
[42].轰志伟,郭黎明,李枫.疏胆和胃汤治疗胆汁反流性胃炎68例.辽宁中医杂志,1989,13(4):26.
[43].徐肇敏,幸宜芬,任雪峰.熊去氧胆酸及普瑞博思治疗碱性反流性胃炎的实验研究.中华消化杂志,1997.17(4):201-203.
[44].Tonini M.Recent advances in the pharmacology of gastrointestinal prokinetics.Pharmacol Res,1996:33(4-5):217-226.
[45].杨泽之,邵雪峰,张晓萍等.二甲基硅油治疗胆汁反流的临床实验室研究.临床消化病杂志,1997,9(2):70-72.
[46].宋国增,苏国琳,张忠惠等.中西医分组治疗胆汁反流性胃炎54例.中西医结合杂志,1987,7(6):345-346.
[47].淡培凤,孙咸茂.中西医结合治疗胆汁反流性胃炎的疗效分析.中西医结合杂志,1991,11(9):541-542.
[48].张德超,胆汁返流性胃炎中医证治心得.中医杂志,1992,33(1):22-33.
[49].曾锦章,张万岱,张洪海等.慢性胃炎的中医辨证与胆汁反流关系的研究.中国中西医结合脾胃杂志,1996,4(4):196-199.
[50].周大业,李方儒,刘淑云.胆汁反流性胃炎113例分析.天津医药,1984,12(3):162-165.
[51].许尤琪.浅论胆胃在生理上的相关性.陕西中医,1991,12(9):409-410.
[52].李恩复.JoanaH,林兆鑫,等.洛塞克对胃十二指肠黏膜保护作用的机制再探.中华消化杂志,2002,34.
[53].张万岱.曾锦章.胆汁反流性胃炎的胃运动功能研究.胃肠病学,1997,2:71-73.
[54].侯家玉.杨鸿.胆汁反流致慢性萎缩性胃炎的实验研究.北京中医药大学报,2001(05):15-16.
[55].Haba T,Sarma SK.Regulation of gastroduodenal emptying of solids by gastro pyloro-duodenal contractions.Am J Physiol,1993,264-261.
[56].曾锦章,张万岱,张洪海等.胆汁反流性胃炎诊断标准的探讨.中国实用内科杂志,1997,17:406-408.
[1].陈仕珠,张忠兵,荆文科,等.胆汁反流性胃炎患者胃、十二指肠粘膜胃肠激素含量及其意义研究.新消化病学杂志,1993,1(14):208-210.
[2].Miwa K,Hattori T,Miyazaki I.Duodenogastric reflux and foregut carcinogenesis.Cancer,1995,75(6):1426 - 1432.
[3].Madura JA.Primary bile reflux gastritis:which treatment is better,Roux-en-Y or biliary diversion?Am Surg,2000,66(5):417-423.
[4].谷成明,柯美云,朱昭辉,等.胃中间横带在调节糖尿病的胃内食物分布和胃排空.中华内科杂志,1999,38:476-477。
[5].郭建强,柯美云,秦明伟,等.胃中间横带对近端胃和远端胃食物分布的调节作用.中国医学科学报,2000,22(5):416-420.
[6].许国铭.胆汁反流相关性疾病.第一版.上海:上海科学技术出版社,2002,34.
[7].张万岱,曾锦章.胆汁反流性胃炎的胃运动功能研究.胃肠病学,1997,2:71-73.
[8].Camilleri M,Brown M and Malagelada JR.Relationship between impaired gastric emptying and abnormal gastrointestinal motility.Gastroenterology,1986,91-94.
[9].Haba T,Sarma SK.Regulation of gastroduodenal emptying of solids by gastropyloroduodenal contractions.Am J Physiol,1993,264-261.
[10].Testoni PA,Fanti L,Bagnolo F,et al.Manometric evaluation of the interdigestive antroduodenal motility in subjects with fasting bile reflux,with and without antral gastritis.Gut,1989,30:443.
[11].M IRANDA m,defilippi C,Valenzuela JE.Abnormalities of interdigestive motility coplex and increased duodenogastric reflux in gastric ulcer patients.Dig Dos Sci,1982,30(1):16-21.
[12].Kellosalo J,Alavaikko M,Laitinen S.Effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa.Scand J Gadtrointerol,1991,26(12):1272-1278.
[13].柯美云,谷成明,姜玉新,等.消化不良患者的胃幽门十二指肠运动协调性研究.中国医学科学院报,2000,2(3):240-244.
[14].刘东明,徐肇敏.胆汁反流性胃炎的病因探讨.中华消化内镜杂志,2003,20(1) 51-52.
[15].冯伟华,周岱云,傅敏,等.胃液胆汁酸与黏膜炎症的关系.中华消化杂志,1992,12(2):78.
[16].陈仕珠,赵红,吴春艳,等.胆汁反流性胃炎患者胆囊排空功能研究.华人消化杂志,1998,6(5):427-428.
[17].陈仕珠,沙建萍,陈旭春,等.胆汁反流性胃炎患者oddi括约肌松弛不良:硝本吡啶改善胆囊排空作用研究,世界华人消化杂志,1999,7(12):1020-1023.
[18].Wilson P,Welch NT,Hinder RA,et al.Abnormal plasma gut hormones in pathologic duodenogastric reflux and theirresponse to surgery.Am JSurg,1993,165(1):169-176.
[19]许国铭.胆汁反流相关性疾病.第一版.上海:上海科学技术出版社,2002,162.
[20].张万岱,曾锦章,彭武和,胆汁反流性胃炎胃排空和促胃液素改变及其意义.解放军医学杂志,1997,22(5):318-320.
[21].陆保林.胆系病变与胆汁反流行胃炎.中国消化病基础与临床,2006,7(5):47-48.
[22].李碧霞.胆汁反流性胃炎150例临床分析.广东医学院学报,1997,2:138-139.
[23].孙绍雄,陈敏清,赵玉芬.胆汁发流性胃炎85例临床分析.实用内科学杂志,1990,10:245.
[24].陈灏珠,李宗明.内科学.第3版.北京:人民卫生出版社,1993,333.
[2].Borsato N,Bonavina L,Zanco P,et al.Proposal of a modified scintigra-Phic method to evaluate duodenogastro-phageal reflux.J NuclMed,1991,32(3):436-440.
[3].Brown TH,Holbrook I,King RFG,et al.24-hour Zntragastric PH measurement in the assessment of duodenogastric reflux.World Jsurg,1992,16(5):995-999.
[4].Stein HJ,Smyrk TL,Demeester TR,et al.Clinical value of endoscopy and histology in the diagnosis of duodenogastric reflux disease.Surgrery,1992,112(4):796.
[5].Hausken T,Odegaard S,Matre K,et al.Antroduodenal motility and movements of luminal contents studied by duplex sonography.Gastroenterology,1992;102(5):1583-1590.
[6].曾锦章,张万岱,张洪海等.胆汁反流性胃炎诊断标准的探讨.中国实用内科杂志,1997.17:406-408.
[7].叶伯墓.胆汁反流性胃炎证治五法.四川中医,1995,13(10):14-15.
[8].殷凤礼,房长茂.对胆汁反流性胃炎的认识及43例临床治疗观察.中医杂志,1984.25(2):23-26.
[9].王啼星,肖汉玺,岳更山.辫证治疗非手术后胆汁反流性胃炎52例.山西中医,1993.9(1):12.
[10].谷成明,柯美云,朱昭辉,等.胃中间横带在调节糖尿病的胃内食物分布和胃排空.中华内科杂志,1999,38.476-477.
[11].江杨消.胆胃相关与胆汁反流性胃炎的证治.中医杂志,1985,26(4):35-37.
[12].郭建强,柯美云,秦明伟,等.胃中间横带对近端胃和远端胃食物分布的调节作用.中国医学科学报,2000,22(5):416-420.
[13].许国铭.胆汁反流相关性疾病.第一版.上海科学技术出版社,2002:34.
[14].张万岱.曾锦章.胆汁反流性胃炎的胃运动功能研究.胃肠病学,1997(2):71-73.
[15].Testoni PA,Fanti L,Bagnolo F,et al.Manometric evaluation of the interdigestive antroduodenal motility in subjects with fasting bile reflux,with and without antral gastritis.Gut.1989,30:443.
[16].Mirandam,defilippi C,Valenzuela JE.Abnormalities of interdigestive motility coplex and increased duodenogastric reflux in gastric ulcer patients.Dig Dos Sci,1982,30(1):16-21.
[17].Kellosalo J,Alavaikko M,Laitinen S.Effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa.Scand J Gadtrointerol,1991,26(12):1272-1278.
[18].柯美云,谷成明,姜玉新,等.消化不良患者的胃幽门十二指肠运动协调性研究.中国医学科学院报,2000,2(3):240-244.
[19].刘东明,徐肇敏.胆汁反流性胃炎的病因探讨.中华消化内镜杂志,2003,20(1) 51-52.
[20].龚茜玲,钱梓文.生理学.第二版.上海医科大学出版社,1992:116-119.
[21].冯伟华,周岱云,傅敏,等.胃液胆汁酸与黏膜炎症的关系.中华消化杂志,1992,12(2):78.
[22].陈仕珠,赵红,吴春艳,等.胆汁反流性胃炎患者胆囊排空功能研究.华人消化杂志,1998,6 (5):427-428.
[23].陈仕珠,沙建萍,陈旭春,等.胆汁反流性胃炎患者oddi括约肌松弛不良:硝本吡啶改善胆囊排空作用研究,世界华人消化杂志,1999,7(12):1020-1023.
[24].Wilson P,Welch NT,Hinder RA,et al.Abnormal plasma gut hormones in pathologic duodenogastric reflux and theirresponse to surgery.Am J Surg,1993,165(1):169-176.
[25].许国铭.胆汁反流相关性疾病.第一版.上海科学技术出版社.2002:162.
[26].张万岱,曾锦章,彭武和.胆汁反流性胃炎胃排空和促胃液素改变及其意义.解放军医学杂志,1997,22(5):318-320.
[27].陆保林.胆系病变与胆汁反流行胃炎.中国消化病基础与临床,2006,7(5):47-48.
[28].陈濒珠.内科学.第三版.人民卫生出版社,1995:333.
[29].Duane WC.Bile acid and bilt disrupt gastric mucosal barrier in the dog by different mechanis.Am J Physiol,1982,242:95.
[30].Bedi BS,Debas HT,Gillespie G,et al.Effect of bile salts on antralgastr in release.Gastroenterol,1971,60:256-262.
[31].Correa P.Chronic gastritis as a cancer precursor.Stand J Gastroenterol,1984,19(Suppl 104):131 - 136.
[32].张万岱.幽门螺杆菌研究的现状与展望.胃肠病学,1997.2(3):129-130.
[33].朱云华,翟颖,朱海青等.反流性胃炎与HP相关胃炎.内镜,1993.10(3):148-150.
[34].杨晋翔.蓝建华老中医从通降论治胆汁返流性胃炎的经验.新中医,1997.29(1):8-9.
[35].李碧霞.胆汁反流性胃炎150例临床分析.广东医学院学报.1997,2:138-139.
[36].孙绍雄.陈敏清.赵玉芬.胆汁发流性胃炎85例临床分析.实用内科学杂志.1990,10:245.
[37].陈灏珠.李宗明.内科学.第3版.人民卫生出版社.1993.333.
[38].王长洪.通降法治疗胆汁反流性胃炎.云南中医杂志,1984.5(1):7-8.
[39].王群.降逆和胃法治疗胆汁返流性胃炎32例.江苏中医,1993,14(7):18.
[40].黄龙辉.胆胃汤治疗慢性胃炎伴胆汁反流48例疗效观察.中国中西医结合脾胃杂,1997,5(1):46.
[41].郭路南,贾广才.中药治疗胆汁反流性胃炎35例.陕西中医.1991.12(3):108.
[42].轰志伟,郭黎明,李枫.疏胆和胃汤治疗胆汁反流性胃炎68例.辽宁中医杂志,1989,13(4):26.
[43].徐肇敏,幸宜芬,任雪峰.熊去氧胆酸及普瑞博思治疗碱性反流性胃炎的实验研究.中华消化杂志,1997.17(4):201-203.
[44].Tonini M.Recent advances in the pharmacology of gastrointestinal prokinetics.Pharmacol Res,1996:33(4-5):217-226.
[45].杨泽之,邵雪峰,张晓萍等.二甲基硅油治疗胆汁反流的临床实验室研究.临床消化病杂志,1997,9(2):70-72.
[46].宋国增,苏国琳,张忠惠等.中西医分组治疗胆汁反流性胃炎54例.中西医结合杂志,1987,7(6):345-346.
[47].淡培凤,孙咸茂.中西医结合治疗胆汁反流性胃炎的疗效分析.中西医结合杂志,1991,11(9):541-542.
[48].张德超,胆汁返流性胃炎中医证治心得.中医杂志,1992,33(1):22-33.
[49].曾锦章,张万岱,张洪海等.慢性胃炎的中医辨证与胆汁反流关系的研究.中国中西医结合脾胃杂志,1996,4(4):196-199.
[50].周大业,李方儒,刘淑云.胆汁反流性胃炎113例分析.天津医药,1984,12(3):162-165.
[51].许尤琪.浅论胆胃在生理上的相关性.陕西中医,1991,12(9):409-410.
[52].李恩复.JoanaH,林兆鑫,等.洛塞克对胃十二指肠黏膜保护作用的机制再探.中华消化杂志,2002,34.
[53].张万岱.曾锦章.胆汁反流性胃炎的胃运动功能研究.胃肠病学,1997,2:71-73.
[54].侯家玉.杨鸿.胆汁反流致慢性萎缩性胃炎的实验研究.北京中医药大学报,2001(05):15-16.
[55].Haba T,Sarma SK.Regulation of gastroduodenal emptying of solids by gastro pyloro-duodenal contractions.Am J Physiol,1993,264-261.
[56].曾锦章,张万岱,张洪海等.胆汁反流性胃炎诊断标准的探讨.中国实用内科杂志,1997,17:406-408.
[1].陈仕珠,张忠兵,荆文科,等.胆汁反流性胃炎患者胃、十二指肠粘膜胃肠激素含量及其意义研究.新消化病学杂志,1993,1(14):208-210.
[2].Miwa K,Hattori T,Miyazaki I.Duodenogastric reflux and foregut carcinogenesis.Cancer,1995,75(6):1426 - 1432.
[3].Madura JA.Primary bile reflux gastritis:which treatment is better,Roux-en-Y or biliary diversion?Am Surg,2000,66(5):417-423.
[4].谷成明,柯美云,朱昭辉,等.胃中间横带在调节糖尿病的胃内食物分布和胃排空.中华内科杂志,1999,38:476-477。
[5].郭建强,柯美云,秦明伟,等.胃中间横带对近端胃和远端胃食物分布的调节作用.中国医学科学报,2000,22(5):416-420.
[6].许国铭.胆汁反流相关性疾病.第一版.上海:上海科学技术出版社,2002,34.
[7].张万岱,曾锦章.胆汁反流性胃炎的胃运动功能研究.胃肠病学,1997,2:71-73.
[8].Camilleri M,Brown M and Malagelada JR.Relationship between impaired gastric emptying and abnormal gastrointestinal motility.Gastroenterology,1986,91-94.
[9].Haba T,Sarma SK.Regulation of gastroduodenal emptying of solids by gastropyloroduodenal contractions.Am J Physiol,1993,264-261.
[10].Testoni PA,Fanti L,Bagnolo F,et al.Manometric evaluation of the interdigestive antroduodenal motility in subjects with fasting bile reflux,with and without antral gastritis.Gut,1989,30:443.
[11].M IRANDA m,defilippi C,Valenzuela JE.Abnormalities of interdigestive motility coplex and increased duodenogastric reflux in gastric ulcer patients.Dig Dos Sci,1982,30(1):16-21.
[12].Kellosalo J,Alavaikko M,Laitinen S.Effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa.Scand J Gadtrointerol,1991,26(12):1272-1278.
[13].柯美云,谷成明,姜玉新,等.消化不良患者的胃幽门十二指肠运动协调性研究.中国医学科学院报,2000,2(3):240-244.
[14].刘东明,徐肇敏.胆汁反流性胃炎的病因探讨.中华消化内镜杂志,2003,20(1) 51-52.
[15].冯伟华,周岱云,傅敏,等.胃液胆汁酸与黏膜炎症的关系.中华消化杂志,1992,12(2):78.
[16].陈仕珠,赵红,吴春艳,等.胆汁反流性胃炎患者胆囊排空功能研究.华人消化杂志,1998,6(5):427-428.
[17].陈仕珠,沙建萍,陈旭春,等.胆汁反流性胃炎患者oddi括约肌松弛不良:硝本吡啶改善胆囊排空作用研究,世界华人消化杂志,1999,7(12):1020-1023.
[18].Wilson P,Welch NT,Hinder RA,et al.Abnormal plasma gut hormones in pathologic duodenogastric reflux and theirresponse to surgery.Am JSurg,1993,165(1):169-176.
[19]许国铭.胆汁反流相关性疾病.第一版.上海:上海科学技术出版社,2002,162.
[20].张万岱,曾锦章,彭武和,胆汁反流性胃炎胃排空和促胃液素改变及其意义.解放军医学杂志,1997,22(5):318-320.
[21].陆保林.胆系病变与胆汁反流行胃炎.中国消化病基础与临床,2006,7(5):47-48.
[22].李碧霞.胆汁反流性胃炎150例临床分析.广东医学院学报,1997,2:138-139.
[23].孙绍雄,陈敏清,赵玉芬.胆汁发流性胃炎85例临床分析.实用内科学杂志,1990,10:245.
[24].陈灏珠,李宗明.内科学.第3版.北京:人民卫生出版社,1993,333.