EMPs作用下人牙龈上皮细胞及牙周膜细胞基因表达差异研究
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摘要
牙周组织再生一直是牙周病治疗领域追求的目标，理想的牙周组织再生需达到以下要求：1)重建功能性上皮封闭；2)新的Sharpey氏纤维插入重建功能性牙周膜；3)暴露根面上形成新的无细胞性牙骨质；4)牙槽骨高度恢复到距釉牙骨质界2mm以内。但由于对牙周组织再生机理认识还不完全清楚，导致目前牙周组织再生还不能完全达到上述要求。
近年发现釉基质蛋白(Enamel Matrix Proteins，EMPs)也可以促进牙周组织再生，它可诱导出无细胞性牙骨质和生理性排列的牙周韧带，且很少伴随有长上皮结合。牙周组织再生的细胞学基础就在于如何促使牙周膜细胞优先占据缺损区、抑制牙龈上皮细胞的过度增殖。EMPs促进牙周组织再生可能遵循这一细胞学机制。但它作为一种细胞外基质蛋白，如何发挥这种作用还不清楚。对此进行深入研究，不仅有助于我们深入了解牙周组织再生的潜在机制，也能够指导临床应用，而且有希望开发出新的效果更好的牙周缺损治疗技术。
本课题以两种与牙周组织再生密切相关的细胞(牙周膜细胞和牙龈上皮细胞)为研究对象，从基因水平初步分析EMPs对它们发挥不同生物学作用的机理。通过本课题的研究，不仅可能发现介导EMPs对细胞增殖发生影响的关键信号转导通路和关键基因、为进一步研究EMPs如何促进牙周组织再生打下基础；而且可能发现参与牙周组织再生的因子。本课题分为两部分。第一部分 EMPs对人牙龈上皮细胞抑制作用的基因表达差异分析
本部分主要研究了EMPs对人牙龈上皮细胞(Human Gingival Epithelial
The regeneration of periodontal attachment apparatus destroyed or lost due to periodontitis is a major objective in periodontal therapy. These destroyed tissues should be repaired and regenerated into physiologic status, which is termed as "true regeneration of periodontal tissues". Recently, a derivative of enamel matrix proteins (EMPs) extracted from porcine tooth buds has been introduced as a device to achieve this goal predictably. They can induce the "true" regeneration of acellular cementum, alveolar bone, and periodontal ligament where the collagen fibers arranged physiologically, which are quite different with the histological results of other methods. However, the underlying biological mechanisms are not so clear.
In this study, we try to explore the genetic mechanism of EMPs in promoting periodontal regeneration by genechip methods. Two kinds of primary cultured cells, human periodontal ligament cells (hPDLCs) and gingival epithelial cells (hGECs), were used because their important role in periodontal tissues regeneration.
Our study would not only map the gene differential expression profiles of hPDLCs or hGECs challenged by EMPs, but also find some key genes and/or signaling pathways, and even some new promoting factors in periodontal regeneration.
We divided our study into 2 parts for the convenience of expression. Both of them shared the common investigation stratege including as follows: chosing a proper content of EMPs and test timepoint for gene chip, exploring the gene differential expression profile of hPDLCs or hGECs challenged by EMPs, and
近年发现釉基质蛋白(Enamel Matrix Proteins，EMPs)也可以促进牙周组织再生，它可诱导出无细胞性牙骨质和生理性排列的牙周韧带，且很少伴随有长上皮结合。牙周组织再生的细胞学基础就在于如何促使牙周膜细胞优先占据缺损区、抑制牙龈上皮细胞的过度增殖。EMPs促进牙周组织再生可能遵循这一细胞学机制。但它作为一种细胞外基质蛋白，如何发挥这种作用还不清楚。对此进行深入研究，不仅有助于我们深入了解牙周组织再生的潜在机制，也能够指导临床应用，而且有希望开发出新的效果更好的牙周缺损治疗技术。
本课题以两种与牙周组织再生密切相关的细胞(牙周膜细胞和牙龈上皮细胞)为研究对象，从基因水平初步分析EMPs对它们发挥不同生物学作用的机理。通过本课题的研究，不仅可能发现介导EMPs对细胞增殖发生影响的关键信号转导通路和关键基因、为进一步研究EMPs如何促进牙周组织再生打下基础；而且可能发现参与牙周组织再生的因子。本课题分为两部分。第一部分 EMPs对人牙龈上皮细胞抑制作用的基因表达差异分析
本部分主要研究了EMPs对人牙龈上皮细胞(Human Gingival Epithelial
The regeneration of periodontal attachment apparatus destroyed or lost due to periodontitis is a major objective in periodontal therapy. These destroyed tissues should be repaired and regenerated into physiologic status, which is termed as "true regeneration of periodontal tissues". Recently, a derivative of enamel matrix proteins (EMPs) extracted from porcine tooth buds has been introduced as a device to achieve this goal predictably. They can induce the "true" regeneration of acellular cementum, alveolar bone, and periodontal ligament where the collagen fibers arranged physiologically, which are quite different with the histological results of other methods. However, the underlying biological mechanisms are not so clear.
In this study, we try to explore the genetic mechanism of EMPs in promoting periodontal regeneration by genechip methods. Two kinds of primary cultured cells, human periodontal ligament cells (hPDLCs) and gingival epithelial cells (hGECs), were used because their important role in periodontal tissues regeneration.
Our study would not only map the gene differential expression profiles of hPDLCs or hGECs challenged by EMPs, but also find some key genes and/or signaling pathways, and even some new promoting factors in periodontal regeneration.
We divided our study into 2 parts for the convenience of expression. Both of them shared the common investigation stratege including as follows: chosing a proper content of EMPs and test timepoint for gene chip, exploring the gene differential expression profile of hPDLCs or hGECs challenged by EMPs, and
引文
~1 Wang HL, Greenwell H, Fiorellini J, Giannobile W, Offenbacher S, Salkin L, Townsend C, Sheridan P, Genco RJ; Research, Science and Therapy Committee. Periodontal regeneration. J Periodontol 2005; 76(9): 1601~1622
~2 Robinson C, Brookes SJ, Shore R.C, Kirkham J. The developing enmel matrix: nature and function. Eur J Oral Sci 1998; 106(Suppl 1): 282~291
~3 Brookes SJ, Robinson C, Kirkham J, Bonass WA. Biochemistry and molecular biology of amelogenin proteins of developing dental enamel. Archs Oral Biol 1995; 40(1): 1~14
~4 Hammarstrom L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscene model in monkeys after application of enamel matrix proteins. J Clin Periodontol 1997; 24 (9 Pt 2): 669~677
~5 Lau EC, Simmer JP, Bringas P, Hsu DD, Hu CC, Zeichner-David M, Thiemann F, Snead ML, Slavkin HC, Fincham AG. Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity. Biochem Biophys Res Comm 1992; 188(3): 1253~1260
~6 Hirooka H. The biologic concept for the use of enamel matrix: true periodontal regeneration. Quintessence Int 1998; 29(10): 621~630
~7 Slavkin HC, Boyde A. Cementum: an epithelial secretory product? J Dent Res 1975; 53: 157
~8 Hamamoto Y, Nakajima T, Ozawa H, Uchida T. Production of amelogenin by enamel epithelium of Hertwig's root sheath. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81(6): 703~709
~9 Slavkin HC, Bessem C, Fincham AG, Bringas P Jr, Santos V, Snead ML, Zeichner-David M. Human and mouse cementum proteins immunologically related to enamel proteins. Biochim Biophys Acta 1989; 991(1): 12~18
~(10) Hammarstrom L. The role of enamel matrix proteins in the development of cementum and periodontal tissues. Ciba Found Syrup 1997; 205: 246~255; discussion 255~260
~(11) Tompkins K, Veis A. Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture. Connect Tissue Res 2002; 43(2-3): 224~231
~(12) Hatakeyama J, Sreenath T, Hatakeyama Y, Thyagarajan T, Shum L, Gibson CW, Wright JT, Kulkarni AB. The receptor activator of nuclear factor-κB ligand-mediated osteoclastogenic pathway is elevatated in amelogenin-null mice. J Bio Chem 2003; 278(37): 35743~35748
~(13) Brice GL, Sampson WJ, Sims MR. An ultrastructureal evaluation of the relationship between epithelial rests of Malassz and orthodontic root resorption and repair in man. Aust Orthod J 1991; 12(2): 90~94
~(14) Hasegawa N, Kawaguchi H, Ogawa T, Uchida T, Kurihara H. Immunohistochemical characteristics of epithelial cell rests of Malassez during cementum repair. J Periodontal Res 2003; 38(1): 51~56
~(15) Luo W, Slavkin HC, Snead ML. Cells from Hertwig's epithelial root sheath do not transcribe amelogenin. J Periodont Res 1991; 26(1): 42~47
~(16) Bosshardt DD, Nanci A. Immunolocalization of epithelial and mesenchymal matrix constituents in association with inner enamel epithelial cells. J Histochem Cytochem 1998; 46(2): 135~142
~(17) Bosshardt DD, Nanci A. Hertwig's epithelial root sheath, enamel matrix proteins, and initiation of cementogenesis in porcine teeth. J Clin Periodonto12004; 31(3): 184~192
~(18) Oida S, Nagano T, Yamakoshi Y, Ando H, Yamada M, Fukae M. Amelogenin gene expression in porcine odontoblasts. J Dent Res 2002; 81 (2): 103~108
~(19) Papagerakis P, MacDougall M, Hotton D, Bailleul-Forestier I, Oboeuf M, Berdal A. Expression of amelogenin in odontoblasts. Bone 2003; 32(3): 228~240
~(20) Wang HL, MacNeil RL. Guided tissue regeneration. Absorbable barriers. Dent Clin North Am 1998; 42(3): 505~522
~(21) Melcher AH, McCulloch CA, Cheong T, Nemeth E, Shiga A. Cells from bone synthesize cementum-like and bone-like tissue in vitro and may migrate into periodontal ligament in vivo. J Periodontal Res 1987;22(3):246~247
~(22) Nohutcu RM, Somerman MJ, McCauley LK. Dexamethasone enhances the effects of parathyroid hormone on human periodontal ligament cells in vitro. Calcif Tissue Int 1995; 56(6): 571~577
~(23) Rincon JC, Xiao Y, Young WG, Bartold PM. Enhanced proliferation, attachment and osteopontin expression by porcine periodontal cells exposed to Emdogain. Arch Oral Bio1 2005; 50(12): 1047~1054
~(24) Hoang AM, Oates TW, Cochran DL. In vitro wound healing responses to enamel matrix derivative. JPeriodontol 2000; 71 (8) : 1270-1277
25 Matsuda N. , Horikawa M. , Watanabe M. , Kitagawa S, Kudo Y, Takata T. Possible involvement of extracellular signal-regulated kinases 1/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative. Eur J Oral Sci 2002; 110 (6) : 439～444
26 Okubo K, Kobayashi M, Takiguchi T, Takada T, Ohazama A, Okamatsu Y, Hasegawa K. Participation of endogenous IGF-and TGF-betal with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells. J Periodont Res 2003; 38 (1) : 1～9
27 Haase HR, Bartold PM. Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells. J Periodontul 2001; 72 (3) : 341～348
28 Lyngstadaas SP, Lundberg E, Ekdahi H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol 2001; 28 (2) : 181～188
29 Davenport DR, Mailhot JM, Wataha JC, Billman MA, Sharawy MM Shrout MK. Effects of enamel matrix protein application on the viability, proliferation, and attachment of human periodontal ligament fibroblasts to diseased root surfaces in vitro. J Clin Periodontol 2003; 30 (2) : 125～131
30 Suzuki N, Ohyama M, Maeno M, Ito K, Otsuka K. Attachment of human ligament ceils to enamel matrix-derived proteins is mediated via interaction between BSP-like molecules and integrin alpha(v)beta3. J Periodontol 2001; 72 (11) : 1520～1526
31 杜岩，吴织芬，董广英，万玲；袁乃梅；刘玲霞．釉基质蛋白对人牙周膜细胞形成Ⅰ型胶原、Ⅲ型胶原的影响．牙体牙髓牙周病学杂志 2003；13(3)：123～126
32 Inoue M, LeGeros RZ, Hoffman C, Diamond K, Rosenberg PA, Craig RG. Effect of enamel matrix proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. J Biomed Mater Res A 2004; 69 (1) : 172～179
33 Gao J, Symons AL, Haase H, Bartold PM. Should cementoblasts express alkaline phosphatase activity? Preliminary study of rat cementoblasts in vitro. J Periodontol 1999; 70 (9) : 951～959
34 Ashkenazi M, Shaked I. In vitro clonogenic capacity of periodontal ligament fibrobtasts cultured with Emdogain. Dent Traumatol 2006; 22 (1) : 25～29
35 Schwartz Z, Carnes DL, Pulliam R, Lohmann CH, Sylvia VL, Liu Y, Dean DD, Cochran DL, Boyan BD. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000; 71 (8) : 1287～1296
36 Tokiyasu Y, Takata T, Saygin E, Somerman M. Enamel factors regulate expression of gone associated with cementoblasts. J Periodontol 2000; 71 (12) : 1829～1839
37 He J, King Y, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Enamel matrix derivative inhibits TNF-alpha-induced apoptosis in osteoblastic MC3T3-El cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99 (6) : 761～767
38 Dean DD, Lohmann CH, Sylvia VL, Cochran DL, Liu Y, Boyan BD, Schwartz Z. Effect of porcine fetal enamel matrix derivative on chondrocyte proliferation, differentiation, and local factor production is dependent on cell maturation state. Cells Tissues Organs 2002; 171 (2-3) : 117～127
39 Keila S, Nemcovsky CE, Moses O, Artzi Z, Weinreb M. In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts. J Dent Res 2004; 83 (2) : 134～138
40 Shimizu E, Nakajima Y, Kato N, Nakayama Y, Saito R, Samoto H, Ogata Y. Regulation of rat bone sialoprotein gene transcription by enamel matrix derivative. J Periodontol 2004; 75 (2) : 260～267
41 Gurpinar A, Onur MA, Cehreli ZC, Tasman F. Effect of enamel matrix derivative on mouse fibroblasts and marrow stromal osteoblasts. J Biomater Appl 2003; 18 (1) : 25～33
42 Otsuka T, Kasai H, Yamaguchi K, Nishihara T. Enamel matrix derivative promotes osteoclast cell formation by RANKL production in mouse marrow cultures. J Dent 2005; 33 (9) : 749～755
43 Kawase T, Okuda K, Yoshie H, Bums DM. Cytostatic action of enamel matrix derivative (EMDOGAIN) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodont Res 2000; 35 (5) : 291～300
44 Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Bums DM. Enamel matrix derivative (Emdogain) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodont Res 2001; 36 (6) : 367～376
45 Kawase T, Okuda K, Yoshie H, Bums DM. Anti-TGF-beta antibody blocks enamel matrix??derivative-induced upregulation of p21WAF1/eipl and prevents its inhibition of human oral epthelial cell proliferation. J Periodont Res 2002; 37 (4) : 255～262
46 Tompkins K, Alvares K, George A, Veis A. Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro. J Bone Miner Res 2005; 20 (2) : 341～349
47 Veis A. Amelogenin gene splice products: potential signaling molecules. Cell Mol Life Sci 2003; 60 (1) : 38～55
48 Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, Brownell AG, Jengh SM, Healy KE. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem 2000; 275 (52) : 41263～41272
49 Viswanathan HL, Berry JE, Foster BL, Gibson CW, Li Y, Kulkami AB, Snead ML, Somerman MJ. Amelogenin: a potential regulator of cementum-associated genes. J Periodontol 2003; 74 (10) : 1423～1431
50 Boabaid F, Gibson CW, Kuehl MA, Berry JE, Snead ML, Nociti FH Jr, Katchburian E, Somerman MJ. Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol 2004; 75 (8) : 1126～1136
51 Inaba H, Kawai S, Nakayama K, Okahashi N, Amano A. Effect of enamel matrix derivative on periodontal ligament cells in vitro is diminished by Porphyromonas gingivalis. J Periodontol 2004; 75 (6) : 858～865
52 Shimizu E, Saito R, Nakayama Y, Nakajima Y, Kato N, Takai H, Kim DS, Ami M, Simmer J, Ogata Y. Amelogenin stimulates bone sialoprotein (BSP) expression through fibroblast growth factor 2 response element and transforming growth factor-betal activation element in the promoter of the BSP gene. J Periodontol 2005; 76 (9) : 1482～1489
53 Brett PM, Parkar M, Olsen I, Tonetti M. Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: a model for tissue regeneration J Dent Res 2002; 81 (11) : 776～783
54 Parkar MH, Tonetti M. Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: analysis using cDNA arrays. J Periodontol 2004; 75 (11) : 1539～1546
55 Paine M, Krebsbach P, Chen L, Paine CT, Yamada Y, Deutsch D, Snead ML. Protein-to-protein interactions: Criteria defining self-assembly of the enamel organic matrix. J Dent Res 1998; 77 (3) : 496～502
56 Fincham A, Moradian-Oldak J, Diekwisch T, Lyaruu DM, Wright JT, Bringas P Jr, Slavkin HC. Evidence for amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. J Struct Biol 1995; 115 (1) : 50～59
57 Fincham A, Moradian-Oldak J, Simmer JP. The structural biology of the developing dental enamel matrix. J Struct Biol 1999; 126 (3) : 270～299
58 Moradian-Oldak J. Amelogenins: assembly, processing and control of crystal morphology. Matrix Biol 2001; 2095-6) : 293～305
59 Ten Cate AR. The role of epithelium in the development, structure and function of the tissues of tooth support. Oral Dis 1996; 2 (1) : 55～62
60 Ryu OH, Hu CC, Simmer JP. Biochemical characterization of recombinant mouse amelogenins: protein quantitation, proton absorption, and relative affinity for enamel crystals. Connect Tissue Res 1998; 38 (1-4) : 207～214
61 Hoang AM, Klebe RJ, Steffensen B, Ryu OH, Simmer JP, Cochran DL. Amelogenin is a cell adhesion protein. J Dent Res 2002; 81 (7) : 497～500
62 Grayson RE, Yamakoshi Y, Wood EJ, Agren MS. The effect of the amelogenin fraction of enamel matrix proteins on fibroblast-mediated collagen matrix reorganization. Biomaterials 2006; 27 (15) : 2926～2933
63 Ohyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K, Ito K. Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Peridontol 2002; 73 (5) : 543～550
64 Nebgen DR, Inoue H, Sabsay B, Wei K, Ho CS, Veis A. Identification of the chondrogenic-inducing activity from bovine dentin (bCIA) as a low-molecular-mass amelogenin polypeptide. J Dent Res 1999; 78 (9) : 1484～1494
65 王伟，岳松龄．人胚牙釉质蛋白异位成骨实验．中华口腔医学杂志 1993；28(6)：362～364，384
66 Kim NH, Tominaga K, Tanaka A. Analysis of eosinophilic round bodies formed after injection of enamel matrix derivative into the backs of rats. J Periodontol 2005; 76 (11) : 1934～1941
67 Boyan BD, Weesner TC, Lohmann CH, Andreacchio D, Carnes DL, Dean DD, Cochran DL, Schwartz Z. Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. J Periodontol 2000; 71 (8) : 1278～128668 Koike Y, Murakami S, Matsuzaka K, Inoue T. The effect of Emdogain on ectopic bone formation in tubes of rat demineralized dentin matrix. J Periodontal Res 2005; 40 (5) : 385～394
69 Sawae Y, Sahara T, Kawana F, Sasaki T. Effects of enamel matrix derivative on mineralized tissue formation during bone wound healing in rat parietal bone defects. J Electron Microsc (Tokyo) 2002; 51 (6) : 413～423
70 Maycock J, Wood SR. Brookes SJ, Shore RC, Robinson C, Kirkham J. Characterization of porcine amelogenin preparation, Emdogain, a biological treatment for periodontal disease. Connect Tissue Res 2002; 43 (2-3) : 472～476
71 Moe D, Sailing E, Kirkeby S. Extraction of enamel proteins. Stand J Dent Res 1984; 92 (6) : 503～507
72 Nagano T, Iwata T, Ogata Y, Tanabe T, Gomi K, Fukae M, Arai T, Oida S. Effect of heat treatment on bioactivities of enamel matrix derivatives in human periodontal ligament (HPDL) cells. J Periodontal Res 2004; 39 (4) : 249～256
73 Yamakoshi Y, Tanabe T, Fukae M, Shimizu M. Molecular and cellular biology: porcine amelogenin. CalcifTissue Int 1994; 54 (1) : 69～75
74 Ryu OH, Fincham AG, Hu CC, Zhang C, Qian Q, Bartlett JD, Simmer JP. Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res 1999; 78 (3) : 743～750
75 Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD. Purification, characterization, and cloning of enamel matrix serine proteinase 1. J Dent Res 1998; 77 (2) : 377～386
76 Papagerakis P, Ibarra JM, Inozentseva N, DenBesten P, MacDougall M. Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution. J Dent Res 2005; 84 (7) : 613～617
77 Taylor AL, Haze-Filderman A, Blumenfeld A, Shay B, Dafni L, Rosenfeld E, Leiser Y, Fermon E, Gruenbaum-Cohen Y, Deutsch D. High yield of biologically active recombinant human amelogenin using the baculovirus expression system. Protein Expr Purif 2006; 45 (1) : 43～53
78 He J, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Direct contact between enamel matrix derivative (EMD) and osteoblasts is not required for EMD-induced cell proliferation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 98 (3) : 370～375
79 Suzuki S, Nagano T, Yamakoshi Y, Gomi K, Arai T, Fukae M, Katagiri T, Oida S. Enamel matrix devrivative gel stimulates signal transduction of BMP and TGF-β J Dent Res 2005; 84 (6) : 510～514
80 Iwata T, Morotome Y, Tanabe T, Fukae M, Ishikawa I, Oida S. Noggin blocks osteoinductive activity of porcine enamel extracts. J Dent Res 2002; 81 (6) : 387～391
81 Takayama T, Suzuki N, Narukawa M, Tokunaga T, Otsuka K, Ito K. Enamel matrix derivative stimulates core binding factor alphal/Runt-related transcription factor-2 expression via activation of Smadl in C2C 12 cells. J Periodontol 2005; 76 (2) : 244～249
82 Sculean A, Donos N, Reich E, Karring T, Brecx M. Regeneration ofoxytalan fibres in different types of periodontal defects: a histological study in monkeys. J Periodontal Res 1998; 33 (8) : 453～459
83 Heijl L. Periodontal tissue regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol 1997; 24 (9 Pt 2) : 693～696
84 束蓉，李超伦，刘正，王洪海；陈佩丽：刘文．猪釉基质蛋自的提取及N末端序列分析．口腔医学纵横杂志 1999；15(2)：67～68
85 张丽青，吴织芬，储庆，万玲，袁乃梅．釉基质蛋白治疗人工Ⅱ度根分叉区组织缺损的动物实验研究．牙体牙髓牙周病学杂志 2003；13(10)：565～568
86 Izumi K, Takacs G, Terashi H, Feinberg SE. Ex vivo development of a composite human oral mucosal equivalent. J Oral Maxillofac Surg 1999; 57 (5) : 571-577; discussion 577～578
87 Formanek M, Millesi W, Willheim M, Scheiner O, Komfehl J. Optimized growth medium for primary culture of human oral keratinocytes. Int J Oral Maxillofae Surg 1996; 25 (2) : 157～160
88 Steinman RA, Hoffman B, Iro A, GuilloufC, Liebermann DA, el-Houseini ME. Induction of p~(21WAFI/cipl) during differentiation. Oncogene 1994; 9 (11) : 3389～3396
89 Munneke B, Schlauch KA, Simonsen KL, Beavis WD, Doerge RW. Adding confidence to gene expression clustering. Genetics 2005; 170 (4) : 2003～2011
90 Jarvinen AK, Hautaniemi S, Edgren H, Auvinen P, Saarela J, Kallioniemi OP, Monni O. Are data from different gene expression microarray platforms comparable? Genomics 2004; 83 (6) : 1164～1168
91 Tyers M, Mann M. From genomics to proteomics. Nature 2003; 422 (6928) : 193～19792 Tomizaki KY, Usui K, Mihara H. Protein-detecting microarrays: current accomplishments and requirements. Chembiochem 2005; 6 (5) : 782～799
93 Li J, Pankratz M, Johnson JA. Differential gene expression patterns revealed by oligonucleotide versus long cDNA arrays. Toxicol Sci 2002; 69 (2) : 383～390
94 Carter MG, Hamatani T, Sharov AA, Carmack CE, Qian Y, Aiba K, Ko NT, Dudekula DB, Brzoska PM, Hwang SS, Ko MS. In Situ-Synthesized Novel Microarray Optimized for Mouse Stem Cell and Early Developmental Expression Profiling. Genome Res 2003; 13: 1011～1021
95 Hughes TR, Mao M, Jones AR, Burehard J, Marton MJ, Shannon KW, Lefkowitz SM, Ziman M, Schelter JM, Meyer MR, Kobayashi S, Davis C, Dai H, He YD, Stephaniants SB, Cavet G, Walker WL, West A, Coffey E, Shoemaker DD, Stoughton R, Blanchard AP, Friend SH, Linsley PS. Expression profiling using microarrays fabricated by an ink-jet oligonueleotide synthesizer. Nat Biotechnol 2001; 19 (4) : 342-7
96 Huang A, Ho CS, Ponzielli R, Barsyte-Lovejoy D, Bouffet E, Picard D, Hawkins CE, Penn LZ. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulioblastoma cells. Cancer Res 2005; 65 (13) : 5607～5619.
97 Rehtanz M, Schmidt HM, Warthorst U, Steger G Direct interaction between nueleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol 2004; 24 (5) : 2153～2168.
98 Johnstone RW, Wang J, Tommerup N, Vissing H, Roberts T, Shi Y. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. J Biol Chem 1998; 273 (18) : 10880～10887.
99 Berquin IM, Dziubinski ML, Nolan GP, Ethier SP. A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene 2001; 20 (30) : 4019～4028.
100 Ognjanovic S, Ku TL, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium. Am J Obstet Gynecol 2005; 193 (1) : 273～282.
101 Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG, Alberti S. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas, Int J Cancer 1995; 62 (5) : 610～618.
102 Simon MT, Pauloin A, Normand G, Lieu HT, Mouly H, Pivert G, Carnot F, Tralhao JG, Brechot C, Christa L. HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotie functions through the PKA signaling pathway. FASEB J 2003; 17 (11) : 1441～1450.
103 Kwak JC, Ongusaha PP, Ouchi T, Lee SW. IFI16 as a negative regulator in the regulation of p53 and p21(Wafl). J Biol Chem 2003; 278 (42) : 40899～40904
104 Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 2005; 280 (3) : 2092～2104.
105 Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovie J, Polyak K. HIN-1, a putative eytokine highly expressed in normal but not cancerous mammary epithelial cells. Proc Natl Acad Sci U S A 2001; 98 (17) : 9796～9801
106 Deb SP. Function and dysfunction of the human oncoprotein MDM2. Front Biosci 2002; 7: d235～d243
107 Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, Clemitson JR, Mason A, Bodyeote CL, Raleigh SM, Louis E, Samani NJ. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 2005; 76 (1) : 147～151
108 Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem 2002; 277 (42) : 39887～39898
109 Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H. Overproduction of human Mytl kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol 1999; 19 (7) : 5113～5123.
110 Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY. Functional association of TOF-beta receptor Ⅱ with cyclin B. Oncogene. 1999; 18 (1) : 269～275.
111 Hussein D, Taylor SS. Famesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J Cell Sci 2002; 115(Pt 17) : 3403～3014.
112 Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N. Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors, Oral Oncol??2005; 41 (7) : 716～722.
113 Flatt PM, Tang LJ, Seatena CD, Szak ST, Pietenpol JA. p53 regulation of G(2) checkpoint is retinoblastoma protein dependent. Mol Cell Biol 2000; 20 (12) : 4210～4223.
114 Li Y, Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science 1996; 274(5285) : 246～248
115 Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. Science 1993; 262 (5132) : 387～395
116 Puga A, Xia Y, Elferink C. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact 2002; 141 (1-2) : 117～130.
117 Shav-Tal Y, Zipori D. The role of activin a in regulation of hemopoiesis. Stem Cells. 2002; 20 (6) : 493～500.
118 Nakamura K, Senda T, Sato K, Mori S, Moriyama M. Accumulation of BCL10 at the perinuclear region is required for the BCL 10-mediated nuclear factor-kappa B activation. Pathobiology 2005; 72 (4) : 191～202.
119 Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Benin J. PYPAF7, a novel PYRIN-containing Apafl-like protein that regulates activation o fNF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem 2002; 277 (33) : 29874～29880
120 Liu XL, Wazer DE, Watanabe K, Band V. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. Cancer Res 1996; 56 (14) : 3371～3379.
121 Zandbergen F, Mandard S, Esther P, Tan NS, Patsouris D, Jatkoe T, Rojas-Caro S, Madore S, Wahli W, Tafuri S, Muller M, Kersten S. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 2005; 392 (Pt 2) : 313～324.
122 Vareli K, Frangou-Lazaridis M, van der Kraan I, Tsolas O, van Driel R. Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. Exp Cell Res 2000; 257 (1) : 152～161.
123 Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 2001; 6 (2) : 107～119.
124 Madge LA, Pober JS. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 2000; 275 (20) : 15458～15465.
125 Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A 1993; 90 (8) : 3516～3520.
126 Imal Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 1999; 398 (6730) : 777～785.
127 Benin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem 2000; 275 (52) : 41082～41086.
128 Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J. Regulation of the MSTI kinase by autophosphorylation, by the growth inhibitory proteins, RASSFI and NOREI, and by Ras. Biochem J 2004; 381 (Pt 2) : 453～462.
129 Liu YF, Dorow D, Marshall J. Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. J Biol Chem 2000; 275 (25) : 19035～19040.
130 Huang YQ, Li JJ, Karpatkin S. Thrombin inhibits tumor cell growth in association with up-regulation of p21 (waf/cip 1) and caspases via a p53-independent, STAT-1-dependent pathway. J Biol Chem 2000; 275 (9) : 6462～6468.
131 Kawal T, Akira S, Reed JC. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol 2003; 23 (17) : 6174～6186.
132 Brunet A, Bonni A, Zigrnond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999; 96 (6) : 857～868.
133 Yu J, Zhang L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell 2003; 4 (4) : 248～249
134 Horiguchi N, Arimoto K, Mizutani A, Endo-lchikawa Y, Nakada H, Taketani S. Galectin-1 induces cell??adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells. J Biochem (Tokyo) 2003; 134 (6) : 869～874.
135 Takahashi H, Hashimoto Y, Ishida-Yamamoto A, Iizuka H. Roxithromycin suppresses involucrin expression by modulation of activator protein-1 and nuclear factor-kappaB activities of keratinocytes. J Dermatol Sci 2005; 39 (3) : 175～182
136 Steinen PM, Kim SY, Chung SI, Marekov LN. The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes. J Biol Chem 1996; 271 (42) : 26242～26250.
137 Munaron L, Antoniotti S, Lovisolo D, et al. Intracellular calcium signals and control of cell proliferation: how many mechanisms? J Cell Mol Med 2004; 8 (2) : 161～168
138 Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast ceils. Mol Pharmacol 1999; 55 (4) : 726～734.
139 Cull-Candy S, Brickiey S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001; 11 (3) : 327～335.
140 Luciakova K, Barath P, Poliakova D, Persson A, Nelson BD. Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. J Biol Chem 2003; 278 (33) : 30624～30633.
141 Zhou J, Yan G, Zhang J, Chang Z. CREB DNA binding activation by a 50-Hz magnetic field in HL60 cells is dependent on extra-and intracellular Ca(2+) but not PKA, PKC, ERK, or p38 MAPK. Biochem Biophys Res Commun 2002; 296 (4) : 1013～1018.
142 Wang MG, Yi H, Guerini D, Klee CB, McBride OW. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. Cytogenet Cell Genet 1996; 72 (2-3) : 236～241.
143 Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A. IL-1 beta scavenging by the type Ⅱ IL-1 decoy receptor in human neutrophils. J Immunol 2003; 170 (12) : 5999～6005.
144 Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Talra K, Uezato H, Ogawa Y, Kariya K. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J Biol Chem 2004; 279 (16) : 15711～15714
145 Hayakawa J, Depatie C, Ohmichi M, Mercola D. The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J Biol Chem 2003; 278 (23) : 20582～20592
146 Lee KH, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG. Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1. J Biol Chem. 2005; 280 (13) : 13179～13186
147 Mulholland DJ, dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with the Wnt/β-Catenin/Tcf signaling axis; Wun you like to know? Endocrine Reviews 2005; 26 (7) : 898～915
148 Golan T, Yaniv A, Bafico A, gnizhong Liu, Gazit A. The human frizzled 6 (HFz6) acts as a negative regulator of the canonical wnt β-catenin signaling cascade. J Biol Chem 2004; 279 (15) : 14879～14888
149 Fedi P, Bafico A, Nieto Sofia A, Burgess WH, Miki T, Bottaro DP, Kraus MH, Aaronson SA. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 1999; 274 (27) : 19465～19472.
150 Holmen SL, Robertson SA, Zylstra CR, Williams BO. Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. Biochem Biophys Res Commun 2005; 328 (2) : 533～539.
151 Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science. 1997; 275 (5307) : 1784～1787.
152 Sun P, Xiong H, Kim TH, Ren B, Zhang Z. Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. Mol Pharmacol 2006; 69 (2) : 520～531
153 van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002; 111 (2) : 241～250.
154 Luo C, Laaja P. Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs. Drug??Discovery Today 2004; 9 (6) : 268～275
155 Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Lamer AC, Finbloom DS. Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jakl arid Jak2, with its receptor. J Biol Chem 1994; 269 (20) : 14333～14336
156 Bhattacharya N, Wang Z, Davitt C, McKenzie IF, Xing PX, Magnuson NS. Pim-1 associates with protein complexes necessary for mitosis. Chromosoma. 2002; 111 (2) : 80～95
157 Liu XD, Sun Y, Weinberg RA, Lodish HF. Ski/Sno and TGF-β signaling. Cytokine and Growth Factor Reviews 2001; 12 (1) 1～8
158 Schluter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD, Gerdes J. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 1993; 123 (3) : 513～522.
159 Nigg EA. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? Curr Opin in Cell Biol 1996; 8 (3) : 312～317
160 Behrens P, Brinkmann U, Wellmann A. CSEIL/CAS: Its role in proliferation and apoptosis. Apoptosis 2003; 8 (1) : 39～44
161 Kim MO, Yun SJ, Kim IS, Sohn S, Lee EH. Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of aipha6beta4 integrin. Neurosci Lett 2003; 336 (2) : 93～96.
162 Skonier J, Neubauer M, Madisen L, Bennett K, Plowman GD, Purchio AF. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol 1992; 11 (7) : 511～522.
163 Jardine H, MacNee W, Donaldson K, Rahman I. Molecular mechanism of transforming growth factor (TGF)-betal-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. J Biol Chem 2002; 277 (24) : 21158～21166
164 Popovici C, Zhang B, Gregoire MJ, Jonveanx P, Lafage-Pochitaloff M, Bimbaum D, Pebusque MJ. The t(6; 8)(q27; p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood 1999; 93 (4) : 1381～1389.
165 Moroz C, Traub L, Maymon R, Zahalka MA. PLIF, a novel human ferritin subunit from placenta with immunosuppressive activity. J Biol Chem 2002; 277 (15) : 12901～12905
166 Wu KJ, Polack A, Dalla-Favera R. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 1999; 283 (5402) : 676～679.
167 Kouprina N, Pavlicek A, Collins NK, Nakano M, Noskov VN, Ohzeki J, Moehida GH, Risinger JI, Goldsmith P, Gunsior M, Solomon G, Gersch W, Kim JH, Barrett JC, Walsh CA, Jurka J, Masumoto H, Larionov V. The microeephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum Mol Genet 2005; 14 (15) : 2155～2165
168 Martin-Lluesma S, Stucke VM, Nigg EA. Role of Hecl in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 2002; 297 (5590) : 2267～2270.
169 Li HY, Zheng Y. Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. Genes Dev 2004; 18 (5) : 512～527
170 Ballabeni A, Melixetian M, Zamponi R, Masiero L, Marinoni F, Helin K. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J 2004; 23 (15) : 3122～3132
171 Pati D, Zhang N, Plon SE. Linking sister chromatid cohesion and apoptosis: role of Rad21. Mol Cell Biol 2002; 22 (23) : 8267～8277.
172 Gaudet S, Branton D, Lue RA. Characterization of PDZ-binding kinase, a mitotic kinase. Proc Natl Acad Sci USA 2000; 97 (10) : 5167～5172
173 Nandi A, Tidwell M, Karp J, Rapoport AP. Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. Blood Cells Mol Dis 2004; 32 (1) : 240～245.
174 Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT. Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. Cancer Res 2000; 60 (13) : 3584～3591.
175 Breen EC, Tang K. Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro. J Cell Biochem 2003; 88 (4) : 848～854.176 Missotten M, Nichols A, Rieger K, Sadoul R. Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ 1999; 6 (2) : 124～129.
177 Ono T, Sekino-Suzuki N, Kikkawa Y, Yonekawa H, Kawashima S. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J Neurosci 2003; 23 (13) : 5887～5896.
178 Rabenau KE, O'Toole JM, Bassi R, Kotanides H, Witte L, Ludwig DL, Pereira DS. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Oncogene 2004; 23 (29) : 5056～5067.
179 Ricort JM, Binoux M. Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway. J Biol Chem 2002; 277 (22) : 19448～19454.
180 Rajah R, Lee KW, Cohen P. Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell Growth Differ 2002; 13 (4) : 163～171.
181 Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE. Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts. J Cell Physiol 2003; 195 (1) : 70～79.
182 Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G. Mehlen P. The netrin-Ⅰ receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 2003; 100 (7) : 4173～4178
183 Saitoh T, Hirai M, Katoh M. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p 11.2. Int J Oncol 2001; 18 (5) : 991～996.
184 Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S. Structural analysis of Siah 1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. J Biol Chem 2005; 280 (40) : 34278～34287.
185 Kurihara H, Shinohara H, Yoshino H, Takeda K, Shiba H. Neurotrophins in cultured cells from periodontal tissues. J Periodontol 2003; 74 (1) : 76～84.
186 Korchynskyi O, ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 2002; 277 (7) : 4883～4891
187 Cheung HW, Ling MT, Tsao SW, Wong YC, Wang X. Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells. Carcinogenesis 2004; 25 (6) : 881～887
188 Ling MT, Wang X, Ouyang XS, Xu K, Tsao SW, Wong YC. Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells. Oncogene 2003; 22 (29) : 4498～4508.
189 Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003; 11 (1) : 203～213.
190 Bi Y, Stuelten CH, Kilts T, Wadhwa S, Iozzo RV, Robey PG, Chen XD, Young ME Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem 2005; 280 (34) : 30481～30489
~2 Robinson C, Brookes SJ, Shore R.C, Kirkham J. The developing enmel matrix: nature and function. Eur J Oral Sci 1998; 106(Suppl 1): 282~291
~3 Brookes SJ, Robinson C, Kirkham J, Bonass WA. Biochemistry and molecular biology of amelogenin proteins of developing dental enamel. Archs Oral Biol 1995; 40(1): 1~14
~4 Hammarstrom L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscene model in monkeys after application of enamel matrix proteins. J Clin Periodontol 1997; 24 (9 Pt 2): 669~677
~5 Lau EC, Simmer JP, Bringas P, Hsu DD, Hu CC, Zeichner-David M, Thiemann F, Snead ML, Slavkin HC, Fincham AG. Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity. Biochem Biophys Res Comm 1992; 188(3): 1253~1260
~6 Hirooka H. The biologic concept for the use of enamel matrix: true periodontal regeneration. Quintessence Int 1998; 29(10): 621~630
~7 Slavkin HC, Boyde A. Cementum: an epithelial secretory product? J Dent Res 1975; 53: 157
~8 Hamamoto Y, Nakajima T, Ozawa H, Uchida T. Production of amelogenin by enamel epithelium of Hertwig's root sheath. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81(6): 703~709
~9 Slavkin HC, Bessem C, Fincham AG, Bringas P Jr, Santos V, Snead ML, Zeichner-David M. Human and mouse cementum proteins immunologically related to enamel proteins. Biochim Biophys Acta 1989; 991(1): 12~18
~(10) Hammarstrom L. The role of enamel matrix proteins in the development of cementum and periodontal tissues. Ciba Found Syrup 1997; 205: 246~255; discussion 255~260
~(11) Tompkins K, Veis A. Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture. Connect Tissue Res 2002; 43(2-3): 224~231
~(12) Hatakeyama J, Sreenath T, Hatakeyama Y, Thyagarajan T, Shum L, Gibson CW, Wright JT, Kulkarni AB. The receptor activator of nuclear factor-κB ligand-mediated osteoclastogenic pathway is elevatated in amelogenin-null mice. J Bio Chem 2003; 278(37): 35743~35748
~(13) Brice GL, Sampson WJ, Sims MR. An ultrastructureal evaluation of the relationship between epithelial rests of Malassz and orthodontic root resorption and repair in man. Aust Orthod J 1991; 12(2): 90~94
~(14) Hasegawa N, Kawaguchi H, Ogawa T, Uchida T, Kurihara H. Immunohistochemical characteristics of epithelial cell rests of Malassez during cementum repair. J Periodontal Res 2003; 38(1): 51~56
~(15) Luo W, Slavkin HC, Snead ML. Cells from Hertwig's epithelial root sheath do not transcribe amelogenin. J Periodont Res 1991; 26(1): 42~47
~(16) Bosshardt DD, Nanci A. Immunolocalization of epithelial and mesenchymal matrix constituents in association with inner enamel epithelial cells. J Histochem Cytochem 1998; 46(2): 135~142
~(17) Bosshardt DD, Nanci A. Hertwig's epithelial root sheath, enamel matrix proteins, and initiation of cementogenesis in porcine teeth. J Clin Periodonto12004; 31(3): 184~192
~(18) Oida S, Nagano T, Yamakoshi Y, Ando H, Yamada M, Fukae M. Amelogenin gene expression in porcine odontoblasts. J Dent Res 2002; 81 (2): 103~108
~(19) Papagerakis P, MacDougall M, Hotton D, Bailleul-Forestier I, Oboeuf M, Berdal A. Expression of amelogenin in odontoblasts. Bone 2003; 32(3): 228~240
~(20) Wang HL, MacNeil RL. Guided tissue regeneration. Absorbable barriers. Dent Clin North Am 1998; 42(3): 505~522
~(21) Melcher AH, McCulloch CA, Cheong T, Nemeth E, Shiga A. Cells from bone synthesize cementum-like and bone-like tissue in vitro and may migrate into periodontal ligament in vivo. J Periodontal Res 1987;22(3):246~247
~(22) Nohutcu RM, Somerman MJ, McCauley LK. Dexamethasone enhances the effects of parathyroid hormone on human periodontal ligament cells in vitro. Calcif Tissue Int 1995; 56(6): 571~577
~(23) Rincon JC, Xiao Y, Young WG, Bartold PM. Enhanced proliferation, attachment and osteopontin expression by porcine periodontal cells exposed to Emdogain. Arch Oral Bio1 2005; 50(12): 1047~1054
~(24) Hoang AM, Oates TW, Cochran DL. In vitro wound healing responses to enamel matrix derivative. JPeriodontol 2000; 71 (8) : 1270-1277
25 Matsuda N. , Horikawa M. , Watanabe M. , Kitagawa S, Kudo Y, Takata T. Possible involvement of extracellular signal-regulated kinases 1/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative. Eur J Oral Sci 2002; 110 (6) : 439～444
26 Okubo K, Kobayashi M, Takiguchi T, Takada T, Ohazama A, Okamatsu Y, Hasegawa K. Participation of endogenous IGF-and TGF-betal with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells. J Periodont Res 2003; 38 (1) : 1～9
27 Haase HR, Bartold PM. Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells. J Periodontul 2001; 72 (3) : 341～348
28 Lyngstadaas SP, Lundberg E, Ekdahi H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol 2001; 28 (2) : 181～188
29 Davenport DR, Mailhot JM, Wataha JC, Billman MA, Sharawy MM Shrout MK. Effects of enamel matrix protein application on the viability, proliferation, and attachment of human periodontal ligament fibroblasts to diseased root surfaces in vitro. J Clin Periodontol 2003; 30 (2) : 125～131
30 Suzuki N, Ohyama M, Maeno M, Ito K, Otsuka K. Attachment of human ligament ceils to enamel matrix-derived proteins is mediated via interaction between BSP-like molecules and integrin alpha(v)beta3. J Periodontol 2001; 72 (11) : 1520～1526
31 杜岩，吴织芬，董广英，万玲；袁乃梅；刘玲霞．釉基质蛋白对人牙周膜细胞形成Ⅰ型胶原、Ⅲ型胶原的影响．牙体牙髓牙周病学杂志 2003；13(3)：123～126
32 Inoue M, LeGeros RZ, Hoffman C, Diamond K, Rosenberg PA, Craig RG. Effect of enamel matrix proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. J Biomed Mater Res A 2004; 69 (1) : 172～179
33 Gao J, Symons AL, Haase H, Bartold PM. Should cementoblasts express alkaline phosphatase activity? Preliminary study of rat cementoblasts in vitro. J Periodontol 1999; 70 (9) : 951～959
34 Ashkenazi M, Shaked I. In vitro clonogenic capacity of periodontal ligament fibrobtasts cultured with Emdogain. Dent Traumatol 2006; 22 (1) : 25～29
35 Schwartz Z, Carnes DL, Pulliam R, Lohmann CH, Sylvia VL, Liu Y, Dean DD, Cochran DL, Boyan BD. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000; 71 (8) : 1287～1296
36 Tokiyasu Y, Takata T, Saygin E, Somerman M. Enamel factors regulate expression of gone associated with cementoblasts. J Periodontol 2000; 71 (12) : 1829～1839
37 He J, King Y, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Enamel matrix derivative inhibits TNF-alpha-induced apoptosis in osteoblastic MC3T3-El cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 99 (6) : 761～767
38 Dean DD, Lohmann CH, Sylvia VL, Cochran DL, Liu Y, Boyan BD, Schwartz Z. Effect of porcine fetal enamel matrix derivative on chondrocyte proliferation, differentiation, and local factor production is dependent on cell maturation state. Cells Tissues Organs 2002; 171 (2-3) : 117～127
39 Keila S, Nemcovsky CE, Moses O, Artzi Z, Weinreb M. In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts. J Dent Res 2004; 83 (2) : 134～138
40 Shimizu E, Nakajima Y, Kato N, Nakayama Y, Saito R, Samoto H, Ogata Y. Regulation of rat bone sialoprotein gene transcription by enamel matrix derivative. J Periodontol 2004; 75 (2) : 260～267
41 Gurpinar A, Onur MA, Cehreli ZC, Tasman F. Effect of enamel matrix derivative on mouse fibroblasts and marrow stromal osteoblasts. J Biomater Appl 2003; 18 (1) : 25～33
42 Otsuka T, Kasai H, Yamaguchi K, Nishihara T. Enamel matrix derivative promotes osteoclast cell formation by RANKL production in mouse marrow cultures. J Dent 2005; 33 (9) : 749～755
43 Kawase T, Okuda K, Yoshie H, Bums DM. Cytostatic action of enamel matrix derivative (EMDOGAIN) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodont Res 2000; 35 (5) : 291～300
44 Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Bums DM. Enamel matrix derivative (Emdogain) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodont Res 2001; 36 (6) : 367～376
45 Kawase T, Okuda K, Yoshie H, Bums DM. Anti-TGF-beta antibody blocks enamel matrix??derivative-induced upregulation of p21WAF1/eipl and prevents its inhibition of human oral epthelial cell proliferation. J Periodont Res 2002; 37 (4) : 255～262
46 Tompkins K, Alvares K, George A, Veis A. Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro. J Bone Miner Res 2005; 20 (2) : 341～349
47 Veis A. Amelogenin gene splice products: potential signaling molecules. Cell Mol Life Sci 2003; 60 (1) : 38～55
48 Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, Brownell AG, Jengh SM, Healy KE. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem 2000; 275 (52) : 41263～41272
49 Viswanathan HL, Berry JE, Foster BL, Gibson CW, Li Y, Kulkami AB, Snead ML, Somerman MJ. Amelogenin: a potential regulator of cementum-associated genes. J Periodontol 2003; 74 (10) : 1423～1431
50 Boabaid F, Gibson CW, Kuehl MA, Berry JE, Snead ML, Nociti FH Jr, Katchburian E, Somerman MJ. Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol 2004; 75 (8) : 1126～1136
51 Inaba H, Kawai S, Nakayama K, Okahashi N, Amano A. Effect of enamel matrix derivative on periodontal ligament cells in vitro is diminished by Porphyromonas gingivalis. J Periodontol 2004; 75 (6) : 858～865
52 Shimizu E, Saito R, Nakayama Y, Nakajima Y, Kato N, Takai H, Kim DS, Ami M, Simmer J, Ogata Y. Amelogenin stimulates bone sialoprotein (BSP) expression through fibroblast growth factor 2 response element and transforming growth factor-betal activation element in the promoter of the BSP gene. J Periodontol 2005; 76 (9) : 1482～1489
53 Brett PM, Parkar M, Olsen I, Tonetti M. Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: a model for tissue regeneration J Dent Res 2002; 81 (11) : 776～783
54 Parkar MH, Tonetti M. Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: analysis using cDNA arrays. J Periodontol 2004; 75 (11) : 1539～1546
55 Paine M, Krebsbach P, Chen L, Paine CT, Yamada Y, Deutsch D, Snead ML. Protein-to-protein interactions: Criteria defining self-assembly of the enamel organic matrix. J Dent Res 1998; 77 (3) : 496～502
56 Fincham A, Moradian-Oldak J, Diekwisch T, Lyaruu DM, Wright JT, Bringas P Jr, Slavkin HC. Evidence for amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. J Struct Biol 1995; 115 (1) : 50～59
57 Fincham A, Moradian-Oldak J, Simmer JP. The structural biology of the developing dental enamel matrix. J Struct Biol 1999; 126 (3) : 270～299
58 Moradian-Oldak J. Amelogenins: assembly, processing and control of crystal morphology. Matrix Biol 2001; 2095-6) : 293～305
59 Ten Cate AR. The role of epithelium in the development, structure and function of the tissues of tooth support. Oral Dis 1996; 2 (1) : 55～62
60 Ryu OH, Hu CC, Simmer JP. Biochemical characterization of recombinant mouse amelogenins: protein quantitation, proton absorption, and relative affinity for enamel crystals. Connect Tissue Res 1998; 38 (1-4) : 207～214
61 Hoang AM, Klebe RJ, Steffensen B, Ryu OH, Simmer JP, Cochran DL. Amelogenin is a cell adhesion protein. J Dent Res 2002; 81 (7) : 497～500
62 Grayson RE, Yamakoshi Y, Wood EJ, Agren MS. The effect of the amelogenin fraction of enamel matrix proteins on fibroblast-mediated collagen matrix reorganization. Biomaterials 2006; 27 (15) : 2926～2933
63 Ohyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K, Ito K. Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Peridontol 2002; 73 (5) : 543～550
64 Nebgen DR, Inoue H, Sabsay B, Wei K, Ho CS, Veis A. Identification of the chondrogenic-inducing activity from bovine dentin (bCIA) as a low-molecular-mass amelogenin polypeptide. J Dent Res 1999; 78 (9) : 1484～1494
65 王伟，岳松龄．人胚牙釉质蛋白异位成骨实验．中华口腔医学杂志 1993；28(6)：362～364，384
66 Kim NH, Tominaga K, Tanaka A. Analysis of eosinophilic round bodies formed after injection of enamel matrix derivative into the backs of rats. J Periodontol 2005; 76 (11) : 1934～1941
67 Boyan BD, Weesner TC, Lohmann CH, Andreacchio D, Carnes DL, Dean DD, Cochran DL, Schwartz Z. Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. J Periodontol 2000; 71 (8) : 1278～128668 Koike Y, Murakami S, Matsuzaka K, Inoue T. The effect of Emdogain on ectopic bone formation in tubes of rat demineralized dentin matrix. J Periodontal Res 2005; 40 (5) : 385～394
69 Sawae Y, Sahara T, Kawana F, Sasaki T. Effects of enamel matrix derivative on mineralized tissue formation during bone wound healing in rat parietal bone defects. J Electron Microsc (Tokyo) 2002; 51 (6) : 413～423
70 Maycock J, Wood SR. Brookes SJ, Shore RC, Robinson C, Kirkham J. Characterization of porcine amelogenin preparation, Emdogain, a biological treatment for periodontal disease. Connect Tissue Res 2002; 43 (2-3) : 472～476
71 Moe D, Sailing E, Kirkeby S. Extraction of enamel proteins. Stand J Dent Res 1984; 92 (6) : 503～507
72 Nagano T, Iwata T, Ogata Y, Tanabe T, Gomi K, Fukae M, Arai T, Oida S. Effect of heat treatment on bioactivities of enamel matrix derivatives in human periodontal ligament (HPDL) cells. J Periodontal Res 2004; 39 (4) : 249～256
73 Yamakoshi Y, Tanabe T, Fukae M, Shimizu M. Molecular and cellular biology: porcine amelogenin. CalcifTissue Int 1994; 54 (1) : 69～75
74 Ryu OH, Fincham AG, Hu CC, Zhang C, Qian Q, Bartlett JD, Simmer JP. Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res 1999; 78 (3) : 743～750
75 Simmer JP, Fukae M, Tanabe T, Yamakoshi Y, Uchida T, Xue J, Margolis HC, Shimizu M, DeHart BC, Hu CC, Bartlett JD. Purification, characterization, and cloning of enamel matrix serine proteinase 1. J Dent Res 1998; 77 (2) : 377～386
76 Papagerakis P, Ibarra JM, Inozentseva N, DenBesten P, MacDougall M. Mouse amelogenin exons 8 and 9: sequence analysis and protein distribution. J Dent Res 2005; 84 (7) : 613～617
77 Taylor AL, Haze-Filderman A, Blumenfeld A, Shay B, Dafni L, Rosenfeld E, Leiser Y, Fermon E, Gruenbaum-Cohen Y, Deutsch D. High yield of biologically active recombinant human amelogenin using the baculovirus expression system. Protein Expr Purif 2006; 45 (1) : 43～53
78 He J, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Direct contact between enamel matrix derivative (EMD) and osteoblasts is not required for EMD-induced cell proliferation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 98 (3) : 370～375
79 Suzuki S, Nagano T, Yamakoshi Y, Gomi K, Arai T, Fukae M, Katagiri T, Oida S. Enamel matrix devrivative gel stimulates signal transduction of BMP and TGF-β J Dent Res 2005; 84 (6) : 510～514
80 Iwata T, Morotome Y, Tanabe T, Fukae M, Ishikawa I, Oida S. Noggin blocks osteoinductive activity of porcine enamel extracts. J Dent Res 2002; 81 (6) : 387～391
81 Takayama T, Suzuki N, Narukawa M, Tokunaga T, Otsuka K, Ito K. Enamel matrix derivative stimulates core binding factor alphal/Runt-related transcription factor-2 expression via activation of Smadl in C2C 12 cells. J Periodontol 2005; 76 (2) : 244～249
82 Sculean A, Donos N, Reich E, Karring T, Brecx M. Regeneration ofoxytalan fibres in different types of periodontal defects: a histological study in monkeys. J Periodontal Res 1998; 33 (8) : 453～459
83 Heijl L. Periodontal tissue regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol 1997; 24 (9 Pt 2) : 693～696
84 束蓉，李超伦，刘正，王洪海；陈佩丽：刘文．猪釉基质蛋自的提取及N末端序列分析．口腔医学纵横杂志 1999；15(2)：67～68
85 张丽青，吴织芬，储庆，万玲，袁乃梅．釉基质蛋白治疗人工Ⅱ度根分叉区组织缺损的动物实验研究．牙体牙髓牙周病学杂志 2003；13(10)：565～568
86 Izumi K, Takacs G, Terashi H, Feinberg SE. Ex vivo development of a composite human oral mucosal equivalent. J Oral Maxillofac Surg 1999; 57 (5) : 571-577; discussion 577～578
87 Formanek M, Millesi W, Willheim M, Scheiner O, Komfehl J. Optimized growth medium for primary culture of human oral keratinocytes. Int J Oral Maxillofae Surg 1996; 25 (2) : 157～160
88 Steinman RA, Hoffman B, Iro A, GuilloufC, Liebermann DA, el-Houseini ME. Induction of p~(21WAFI/cipl) during differentiation. Oncogene 1994; 9 (11) : 3389～3396
89 Munneke B, Schlauch KA, Simonsen KL, Beavis WD, Doerge RW. Adding confidence to gene expression clustering. Genetics 2005; 170 (4) : 2003～2011
90 Jarvinen AK, Hautaniemi S, Edgren H, Auvinen P, Saarela J, Kallioniemi OP, Monni O. Are data from different gene expression microarray platforms comparable? Genomics 2004; 83 (6) : 1164～1168
91 Tyers M, Mann M. From genomics to proteomics. Nature 2003; 422 (6928) : 193～19792 Tomizaki KY, Usui K, Mihara H. Protein-detecting microarrays: current accomplishments and requirements. Chembiochem 2005; 6 (5) : 782～799
93 Li J, Pankratz M, Johnson JA. Differential gene expression patterns revealed by oligonucleotide versus long cDNA arrays. Toxicol Sci 2002; 69 (2) : 383～390
94 Carter MG, Hamatani T, Sharov AA, Carmack CE, Qian Y, Aiba K, Ko NT, Dudekula DB, Brzoska PM, Hwang SS, Ko MS. In Situ-Synthesized Novel Microarray Optimized for Mouse Stem Cell and Early Developmental Expression Profiling. Genome Res 2003; 13: 1011～1021
95 Hughes TR, Mao M, Jones AR, Burehard J, Marton MJ, Shannon KW, Lefkowitz SM, Ziman M, Schelter JM, Meyer MR, Kobayashi S, Davis C, Dai H, He YD, Stephaniants SB, Cavet G, Walker WL, West A, Coffey E, Shoemaker DD, Stoughton R, Blanchard AP, Friend SH, Linsley PS. Expression profiling using microarrays fabricated by an ink-jet oligonueleotide synthesizer. Nat Biotechnol 2001; 19 (4) : 342-7
96 Huang A, Ho CS, Ponzielli R, Barsyte-Lovejoy D, Bouffet E, Picard D, Hawkins CE, Penn LZ. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulioblastoma cells. Cancer Res 2005; 65 (13) : 5607～5619.
97 Rehtanz M, Schmidt HM, Warthorst U, Steger G Direct interaction between nueleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription. Mol Cell Biol 2004; 24 (5) : 2153～2168.
98 Johnstone RW, Wang J, Tommerup N, Vissing H, Roberts T, Shi Y. Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1. J Biol Chem 1998; 273 (18) : 10880～10887.
99 Berquin IM, Dziubinski ML, Nolan GP, Ethier SP. A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin. Oncogene 2001; 20 (30) : 4019～4028.
100 Ognjanovic S, Ku TL, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium. Am J Obstet Gynecol 2005; 193 (1) : 273～282.
101 Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG, Alberti S. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas, Int J Cancer 1995; 62 (5) : 610～618.
102 Simon MT, Pauloin A, Normand G, Lieu HT, Mouly H, Pivert G, Carnot F, Tralhao JG, Brechot C, Christa L. HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotie functions through the PKA signaling pathway. FASEB J 2003; 17 (11) : 1441～1450.
103 Kwak JC, Ongusaha PP, Ouchi T, Lee SW. IFI16 as a negative regulator in the regulation of p53 and p21(Wafl). J Biol Chem 2003; 278 (42) : 40899～40904
104 Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC Jr. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem 2005; 280 (3) : 2092～2104.
105 Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovie J, Polyak K. HIN-1, a putative eytokine highly expressed in normal but not cancerous mammary epithelial cells. Proc Natl Acad Sci U S A 2001; 98 (17) : 9796～9801
106 Deb SP. Function and dysfunction of the human oncoprotein MDM2. Front Biosci 2002; 7: d235～d243
107 Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, Clemitson JR, Mason A, Bodyeote CL, Raleigh SM, Louis E, Samani NJ. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 2005; 76 (1) : 147～151
108 Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. J Biol Chem 2002; 277 (42) : 39887～39898
109 Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H. Overproduction of human Mytl kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol 1999; 19 (7) : 5113～5123.
110 Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY. Functional association of TOF-beta receptor Ⅱ with cyclin B. Oncogene. 1999; 18 (1) : 269～275.
111 Hussein D, Taylor SS. Famesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J Cell Sci 2002; 115(Pt 17) : 3403～3014.
112 Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N. Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors, Oral Oncol??2005; 41 (7) : 716～722.
113 Flatt PM, Tang LJ, Seatena CD, Szak ST, Pietenpol JA. p53 regulation of G(2) checkpoint is retinoblastoma protein dependent. Mol Cell Biol 2000; 20 (12) : 4210～4223.
114 Li Y, Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science 1996; 274(5285) : 246～248
115 Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA. Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control. Science 1993; 262 (5132) : 387～395
116 Puga A, Xia Y, Elferink C. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact 2002; 141 (1-2) : 117～130.
117 Shav-Tal Y, Zipori D. The role of activin a in regulation of hemopoiesis. Stem Cells. 2002; 20 (6) : 493～500.
118 Nakamura K, Senda T, Sato K, Mori S, Moriyama M. Accumulation of BCL10 at the perinuclear region is required for the BCL 10-mediated nuclear factor-kappa B activation. Pathobiology 2005; 72 (4) : 191～202.
119 Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Benin J. PYPAF7, a novel PYRIN-containing Apafl-like protein that regulates activation o fNF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem 2002; 277 (33) : 29874～29880
120 Liu XL, Wazer DE, Watanabe K, Band V. Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. Cancer Res 1996; 56 (14) : 3371～3379.
121 Zandbergen F, Mandard S, Esther P, Tan NS, Patsouris D, Jatkoe T, Rojas-Caro S, Madore S, Wahli W, Tafuri S, Muller M, Kersten S. The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 2005; 392 (Pt 2) : 313～324.
122 Vareli K, Frangou-Lazaridis M, van der Kraan I, Tsolas O, van Driel R. Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication. Exp Cell Res 2000; 257 (1) : 152～161.
123 Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H. Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 2001; 6 (2) : 107～119.
124 Madge LA, Pober JS. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 2000; 275 (20) : 15458～15465.
125 Kozopas KM, Yang T, Buchan HL, Zhou P, Craig RW. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A 1993; 90 (8) : 3516～3520.
126 Imal Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 1999; 398 (6730) : 777～785.
127 Benin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem 2000; 275 (52) : 41082～41086.
128 Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J. Regulation of the MSTI kinase by autophosphorylation, by the growth inhibitory proteins, RASSFI and NOREI, and by Ras. Biochem J 2004; 381 (Pt 2) : 453～462.
129 Liu YF, Dorow D, Marshall J. Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. J Biol Chem 2000; 275 (25) : 19035～19040.
130 Huang YQ, Li JJ, Karpatkin S. Thrombin inhibits tumor cell growth in association with up-regulation of p21 (waf/cip 1) and caspases via a p53-independent, STAT-1-dependent pathway. J Biol Chem 2000; 275 (9) : 6462～6468.
131 Kawal T, Akira S, Reed JC. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol 2003; 23 (17) : 6174～6186.
132 Brunet A, Bonni A, Zigrnond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999; 96 (6) : 857～868.
133 Yu J, Zhang L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell 2003; 4 (4) : 248～249
134 Horiguchi N, Arimoto K, Mizutani A, Endo-lchikawa Y, Nakada H, Taketani S. Galectin-1 induces cell??adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells. J Biochem (Tokyo) 2003; 134 (6) : 869～874.
135 Takahashi H, Hashimoto Y, Ishida-Yamamoto A, Iizuka H. Roxithromycin suppresses involucrin expression by modulation of activator protein-1 and nuclear factor-kappaB activities of keratinocytes. J Dermatol Sci 2005; 39 (3) : 175～182
136 Steinen PM, Kim SY, Chung SI, Marekov LN. The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes. J Biol Chem 1996; 271 (42) : 26242～26250.
137 Munaron L, Antoniotti S, Lovisolo D, et al. Intracellular calcium signals and control of cell proliferation: how many mechanisms? J Cell Mol Med 2004; 8 (2) : 161～168
138 Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast ceils. Mol Pharmacol 1999; 55 (4) : 726～734.
139 Cull-Candy S, Brickiey S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001; 11 (3) : 327～335.
140 Luciakova K, Barath P, Poliakova D, Persson A, Nelson BD. Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. J Biol Chem 2003; 278 (33) : 30624～30633.
141 Zhou J, Yan G, Zhang J, Chang Z. CREB DNA binding activation by a 50-Hz magnetic field in HL60 cells is dependent on extra-and intracellular Ca(2+) but not PKA, PKC, ERK, or p38 MAPK. Biochem Biophys Res Commun 2002; 296 (4) : 1013～1018.
142 Wang MG, Yi H, Guerini D, Klee CB, McBride OW. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. Cytogenet Cell Genet 1996; 72 (2-3) : 236～241.
143 Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A. IL-1 beta scavenging by the type Ⅱ IL-1 decoy receptor in human neutrophils. J Immunol 2003; 170 (12) : 5999～6005.
144 Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Talra K, Uezato H, Ogawa Y, Kariya K. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J Biol Chem 2004; 279 (16) : 15711～15714
145 Hayakawa J, Depatie C, Ohmichi M, Mercola D. The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair. J Biol Chem 2003; 278 (23) : 20582～20592
146 Lee KH, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG. Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1. J Biol Chem. 2005; 280 (13) : 13179～13186
147 Mulholland DJ, dedhar S, Coetzee GA, Nelson CC. Interaction of nuclear receptors with the Wnt/β-Catenin/Tcf signaling axis; Wun you like to know? Endocrine Reviews 2005; 26 (7) : 898～915
148 Golan T, Yaniv A, Bafico A, gnizhong Liu, Gazit A. The human frizzled 6 (HFz6) acts as a negative regulator of the canonical wnt β-catenin signaling cascade. J Biol Chem 2004; 279 (15) : 14879～14888
149 Fedi P, Bafico A, Nieto Sofia A, Burgess WH, Miki T, Bottaro DP, Kraus MH, Aaronson SA. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 1999; 274 (27) : 19465～19472.
150 Holmen SL, Robertson SA, Zylstra CR, Williams BO. Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. Biochem Biophys Res Commun 2005; 328 (2) : 533～539.
151 Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science. 1997; 275 (5307) : 1784～1787.
152 Sun P, Xiong H, Kim TH, Ren B, Zhang Z. Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. Mol Pharmacol 2006; 69 (2) : 520～531
153 van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, Eilers M, Medema R, Clevers H. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002; 111 (2) : 241～250.
154 Luo C, Laaja P. Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs. Drug??Discovery Today 2004; 9 (6) : 268～275
155 Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Lamer AC, Finbloom DS. Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jakl arid Jak2, with its receptor. J Biol Chem 1994; 269 (20) : 14333～14336
156 Bhattacharya N, Wang Z, Davitt C, McKenzie IF, Xing PX, Magnuson NS. Pim-1 associates with protein complexes necessary for mitosis. Chromosoma. 2002; 111 (2) : 80～95
157 Liu XD, Sun Y, Weinberg RA, Lodish HF. Ski/Sno and TGF-β signaling. Cytokine and Growth Factor Reviews 2001; 12 (1) 1～8
158 Schluter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD, Gerdes J. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 1993; 123 (3) : 513～522.
159 Nigg EA. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? Curr Opin in Cell Biol 1996; 8 (3) : 312～317
160 Behrens P, Brinkmann U, Wellmann A. CSEIL/CAS: Its role in proliferation and apoptosis. Apoptosis 2003; 8 (1) : 39～44
161 Kim MO, Yun SJ, Kim IS, Sohn S, Lee EH. Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of aipha6beta4 integrin. Neurosci Lett 2003; 336 (2) : 93～96.
162 Skonier J, Neubauer M, Madisen L, Bennett K, Plowman GD, Purchio AF. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol 1992; 11 (7) : 511～522.
163 Jardine H, MacNee W, Donaldson K, Rahman I. Molecular mechanism of transforming growth factor (TGF)-betal-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. J Biol Chem 2002; 277 (24) : 21158～21166
164 Popovici C, Zhang B, Gregoire MJ, Jonveanx P, Lafage-Pochitaloff M, Bimbaum D, Pebusque MJ. The t(6; 8)(q27; p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood 1999; 93 (4) : 1381～1389.
165 Moroz C, Traub L, Maymon R, Zahalka MA. PLIF, a novel human ferritin subunit from placenta with immunosuppressive activity. J Biol Chem 2002; 277 (15) : 12901～12905
166 Wu KJ, Polack A, Dalla-Favera R. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 1999; 283 (5402) : 676～679.
167 Kouprina N, Pavlicek A, Collins NK, Nakano M, Noskov VN, Ohzeki J, Moehida GH, Risinger JI, Goldsmith P, Gunsior M, Solomon G, Gersch W, Kim JH, Barrett JC, Walsh CA, Jurka J, Masumoto H, Larionov V. The microeephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein. Hum Mol Genet 2005; 14 (15) : 2155～2165
168 Martin-Lluesma S, Stucke VM, Nigg EA. Role of Hecl in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 2002; 297 (5590) : 2267～2270.
169 Li HY, Zheng Y. Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. Genes Dev 2004; 18 (5) : 512～527
170 Ballabeni A, Melixetian M, Zamponi R, Masiero L, Marinoni F, Helin K. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J 2004; 23 (15) : 3122～3132
171 Pati D, Zhang N, Plon SE. Linking sister chromatid cohesion and apoptosis: role of Rad21. Mol Cell Biol 2002; 22 (23) : 8267～8277.
172 Gaudet S, Branton D, Lue RA. Characterization of PDZ-binding kinase, a mitotic kinase. Proc Natl Acad Sci USA 2000; 97 (10) : 5167～5172
173 Nandi A, Tidwell M, Karp J, Rapoport AP. Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. Blood Cells Mol Dis 2004; 32 (1) : 240～245.
174 Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT. Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. Cancer Res 2000; 60 (13) : 3584～3591.
175 Breen EC, Tang K. Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro. J Cell Biochem 2003; 88 (4) : 848～854.176 Missotten M, Nichols A, Rieger K, Sadoul R. Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein. Cell Death Differ 1999; 6 (2) : 124～129.
177 Ono T, Sekino-Suzuki N, Kikkawa Y, Yonekawa H, Kawashima S. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J Neurosci 2003; 23 (13) : 5887～5896.
178 Rabenau KE, O'Toole JM, Bassi R, Kotanides H, Witte L, Ludwig DL, Pereira DS. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Oncogene 2004; 23 (29) : 5056～5067.
179 Ricort JM, Binoux M. Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway. J Biol Chem 2002; 277 (22) : 19448～19454.
180 Rajah R, Lee KW, Cohen P. Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell Growth Differ 2002; 13 (4) : 163～171.
181 Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE. Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts. J Cell Physiol 2003; 195 (1) : 70～79.
182 Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G. Mehlen P. The netrin-Ⅰ receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 2003; 100 (7) : 4173～4178
183 Saitoh T, Hirai M, Katoh M. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p 11.2. Int J Oncol 2001; 18 (5) : 991～996.
184 Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S. Structural analysis of Siah 1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. J Biol Chem 2005; 280 (40) : 34278～34287.
185 Kurihara H, Shinohara H, Yoshino H, Takeda K, Shiba H. Neurotrophins in cultured cells from periodontal tissues. J Periodontol 2003; 74 (1) : 76～84.
186 Korchynskyi O, ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 2002; 277 (7) : 4883～4891
187 Cheung HW, Ling MT, Tsao SW, Wong YC, Wang X. Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells. Carcinogenesis 2004; 25 (6) : 881～887
188 Ling MT, Wang X, Ouyang XS, Xu K, Tsao SW, Wong YC. Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells. Oncogene 2003; 22 (29) : 4498～4508.
189 Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003; 11 (1) : 203～213.
190 Bi Y, Stuelten CH, Kilts T, Wadhwa S, Iozzo RV, Robey PG, Chen XD, Young ME Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem 2005; 280 (34) : 30481～30489