正常高值血压患者高敏C反应蛋白与尿微量白蛋白的相关性
|
摘要
目的观察正常高值血压患者血清高敏C反应蛋白(hs-CRP)与尿微量白蛋白(ALB)的水平,分析二者之间的相关性。
方法选择正常高值血压110例,对照组为同期体检健康者87例,用ELISA法分别测定血清hs-CRP、ALB;空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、体重指数(BMI)。
结果正常高值血压组血清hs-CRP、ALB水平显著高于对照组(P<0.05)；且存在明显性别差异,男性显著高于女性(P<0.05)。hs-CRP与ALB呈正相关(P<0.01, r=0.47), TC、TG、BMI、FBG、LDL均与二者呈正相关(P<0.05)。
结论正常高值血压患者血清hs-CRP、ALB水平明显升高,提示机体已存在炎症反应。TC、TG、BMI、FBG、LDL均是炎症反应的相关因素,雌激素可能对女性心血管系统有保护作用。
Objective
This study was performed to investigate the changes of serum high-sensitivity C-reactive protein level and Albuminuria level in patients with prehypertension and to investigate the relationship between hs-CRP and ALB.
Methods
Total FBG,TC,TG,BMI,LDL were measured in 110 patients with prehypertension and 87 normal controls. Serum hs-CRP and ALB concentration was measured by ELISA.
Result
Prehypertension of serum hs-CRP, urinary albumin concentration was significantly higher than that; and high male than female (P<0.05). hs-CRP, ALB with TC, TG, BMI, FBG, LDL was a positive correlation (All P<0.05).
Conclusion
The serum hs-CRP and ALB level are increased obviously in the patient with prehypertension, prehypertension has an inflammation reaction.The elevated levels of TC, TG, FBG, LDL and BMI all correlate with inflammation. Estrogen on the female cardiovascular system may have protective effects.
方法选择正常高值血压110例,对照组为同期体检健康者87例,用ELISA法分别测定血清hs-CRP、ALB;空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、体重指数(BMI)。
结果正常高值血压组血清hs-CRP、ALB水平显著高于对照组(P<0.05)；且存在明显性别差异,男性显著高于女性(P<0.05)。hs-CRP与ALB呈正相关(P<0.01, r=0.47), TC、TG、BMI、FBG、LDL均与二者呈正相关(P<0.05)。
结论正常高值血压患者血清hs-CRP、ALB水平明显升高,提示机体已存在炎症反应。TC、TG、BMI、FBG、LDL均是炎症反应的相关因素,雌激素可能对女性心血管系统有保护作用。
Objective
This study was performed to investigate the changes of serum high-sensitivity C-reactive protein level and Albuminuria level in patients with prehypertension and to investigate the relationship between hs-CRP and ALB.
Methods
Total FBG,TC,TG,BMI,LDL were measured in 110 patients with prehypertension and 87 normal controls. Serum hs-CRP and ALB concentration was measured by ELISA.
Result
Prehypertension of serum hs-CRP, urinary albumin concentration was significantly higher than that; and high male than female (P<0.05). hs-CRP, ALB with TC, TG, BMI, FBG, LDL was a positive correlation (All P<0.05).
Conclusion
The serum hs-CRP and ALB level are increased obviously in the patient with prehypertension, prehypertension has an inflammation reaction.The elevated levels of TC, TG, FBG, LDL and BMI all correlate with inflammation. Estrogen on the female cardiovascular system may have protective effects.
引文
[l]中国高血压防治指南修订委员会.2004年中国高血压防治指南(试用本)[J].中华心血管病杂志,2004(32)：1060-1064.
[2]《中国高血压防治指南》修订委员会[M]／／刘力生,龚兰生.《中国高血压防治指南》,2005年修订版.人民卫生出版社.
[3]Chobanian AV,Bakris GL,Black HR,et al. The Seventh Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure:the JNC-7 report. JAMA,2003,289:2560-2572.
[4]Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study:a cohort study. Lancet.2001; 358:1682-1686.
[5]Qureshi AI,Suri MFK,Kirmani J F,et al.Is prehypertension a risk factor for cardiovascular disease [J].Stroke,2005,36;1859-1863.
[6]WILL IAMS B,POUL TER N,BROWN M,et al. British Hypertension Society guidelines for hypertension management 2004(BHS-IV):summary[J]. BMJ,2004,328:634-640.
[7]陈捷,赵秀丽,武峰,等.我国14省市中老年人肥胖超重流行现状及其与高血压患病率的关系[J].中华医学杂志,2005,85：2830-2834.
[8].孙佳艺,赵冬,王薇.北京地区2740人的血压水平10年(1992-2002)变化情况[J].高血压杂志,2005,13：115-119.
[9]Bautista LE, Lopez-Jaramillo P,Vera LM, et al. Is C-reactive protein an independent risk factor for essential hypertension [J].J.Hypertens,2001; 19.
[10]Jae, Sae Young PhD; Fernhall, Bo PhD; Lee, Miyoung MS;et,al Exaggerated Blood Pressure Response to Exercise is Associated With Inflammatory Markers.2006 Lippincott Williams& Wilkins, Inc. Volume 26(3), May/June 2006, pp 145-149.
[11]Mancia G,De Backer G, Dom in iczak A, et al 2007 guidelines for the management of arterial hypertension:The task force for the managent of arterial hypertension of the European society of hypertension(ESH) and of the European society of cardiology(ESC). J Hypertens, 2007,25(6):1105-1187.
[12]王薇,赵冬,孙佳艺,等.中国正常高值血压人群的心血管病发病危险.中华高血压杂志,2007,15(12)：984-987.
[13]J Vasan RS, Larson MG, Leip EP, et al. Impact of high, nomal blood pressure on the risk of cardiovascular disease. N Erl91 J Med,2001,345(18):1291-1297.
[14]Zhang Y, Lee ET, Devereux RB, et al. Prehypertension, diabetes, and cardiovascular disease risk in a population. based sample:the stmng heart study. Hypertension,2006,47(3): 410-414.
[15]Liszka HA, Mainous III AG, King DE, et al.Prehypertension and cardiovascular morbidity. Ann Fam Med,2005,3(4):294-299.
[16]Kshirsagar AV, Carpenter M, Bang H, et al. Blood pressure usually considered normal is associated with an elevated risk of cardiovascular disease. Am J Med,2006,119(2):133-141.
[17]Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality:a meta-analysis of individual data for one million adults in 61 prosuective studies.[J] Lancet,2002,360(9349):1903-1913.
[18]Mainous AG, Everett CJ, Liszka H, et al. Prehypertension and mortality in a nationally representative cohort[J]. Am J Cardiol,2004,94(12):1496-1500.
[19]Russell LB, Valiyeva E, Carson JL. Effects of prehypertension on admissions and deaths:a simulation. [J]Arch Intern Med,2004,164(19):2119-2124.
[20]赵冬,王薇,刘静,等.正常高值血压人群10年心血管病发病危险的分析.中华老年脑血管病杂志,2006,8(11)：730-733.
[21]Washio M, Tokunaga S, Yoshimasu K, et al. Role of prehypertension in the development of coronary athemsclerosis inJapan. [J] Epidemiol,2004,14(2):57-62.
[22]Chrysohoou C, Pitsavos C, Panagiotakos DB, et al. Association between prehypertension status and inflammatory markers related to atherosclerotic disease:the ATTICA study. Am[J] Hvpertens,2004,17(7):568-573.
[23]Clansen P, JenserI J. S, Jensen J, et al. Elevated urjnary albuminexcretion is associated with impaired arterial dilatory capacity in clinically healthy slects[J]. Circulation,2001,103: 1869-1874.
[24]Jay PG, Geoge LB. Microalbuminuria:marker of vascular dysfunction, risk factorfor cardiovascular disease [J]. Vascular medicine,2002,7:35-43.
[25]Roberto Pedrinelli, Giulia Dell'Omo, Vitantonio Di Bello, et al. Low-Grade Inflammation and Microalbuminuria in Hypertension [J]. Arteriosclerosis, Thrombosis, and Vascular Biolog, 2004,24:2414.
[26]Hashimoto H, Kitagawa K, Hougaku H, et al. Relationship between C-reactive protein and progression of early carotidatherosclerosis in hypertensive subjects [J].Stroke,2004,35:1625-1630.
[27]Teoh H, Quan A, Leung SW. Diffirential effects of 17 betaestrodio 1 and testosterone on the contractile responses of porcine coronary arteries [J]. Br J Pharmacol,2000,129:1301-1308.
[28]Dubey RK, Jackson EK, Gillespie DG, et al. Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity[J]. A-rterioscler Thromb V asc Bio l,2000,20:964-972.
[29]GordonM S, Chin WW, Shupnik MA. Regulation of angio tensinogen gene expression by estrogen [J], J Hypertens,1992,10:361-366.
[1]Prospective Studies Collaboration. Agespecific relevance of usual blood pressure to vascular mortality:a metaanalysis of individual data for one million adults in 61 prospective studies[J].Lancet,2002,360:1903-1913.
[2]王薇,赵冬,刘静,等.中国35-64岁人群血压水平与10年心血管病发病危险的前瞻性研究[J].中华内科杂志,2004,43：7302734.
[3]Chobanian AV, Bakris GL, Black HR, et al. National heart,lung and blood institute joint national committee on prevention,detection, evaluation, and treatment of high blood pressure;national high blood pressure education program coordinating committee. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure:the JNC 7 report [J]. JAMA,2003,289:2560-2572
[4]《中国高血压防治指南》修订委员会[M]／／刘力生,龚兰生.《中国高血压防治指南》,2005年修订版.人民卫生出社.n
[5]j Gu D, Wildman RP, Wu X, et al. Incidence and predictors of hypertension over 8 years among Chinese men and women. [J]Hypertens,2007,25(3):517-523.
[6]Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and st-roke,13000 stroke in 450000 people in 45 prospective cohort s[J]. Lancet; 1995:346:1647-1655.
[7]Eastern Stroke and Coronary Heart Disease Collaborative Research Group. Blood pressure cholesterol and stroke in eastern Asia [J]. Lancet; 1999,352:1801-1807.
[8]王薇,赵冬,刘静,等.中国35-64岁人群血压水平与10年心血管病发病危险的前瞻性研究[J].高血压杂志,2004,12：S829.
[9]Vasan RS, Larson MG, Leip EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease[J]. N Engl J Med,2001,345:1291-1297.
[10]Adler AI, St raton IM, Neil HAW, et al. Association of systolic blood pressure wit h-macrovascular and microvascular complication of type 2 diabetes (U KPDS 36):prospective observationalstudy[J]. BMJ,2000,321:412-419.
[11]国家“十五”攻关冠心病、脑卒中综合危险因素危险度评估及干预研究课题组(武阳丰).国人缺血性心血管病发病危险的评估方法及简易评估工具的开发研究[J].中华心血管病杂志,2003,31：893-901.
[12]J Vasan RS, Larson MG, Leip EP, et al. Assessent of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study:a cohort study [J]Lancet,2001,358(9294):1682-1686.
[13]WaIlg Y, Wang QJ. The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines:new challenges of the old problem [J]Arch Intern Med,2004,164(19):2126-2134.
[14]赵冬,王薇,刘静,等.正常高值血压人群10年心血管病发病危险的分析.[J]中华老年脑血管病杂志,2006,8(11)：730-733.
[15]Julius S, Nesbitt SD, Egan BM, et al. Feasibility of treating hypertension with an angiotensin-receptor blocker. N Engl [J]Med,2006,354(16):1685-1697.
[16]Eager B Julius S.Vascular hypertrophy in borderline hypertension Relationship to blood pressure and sympathetic drive, Clin Exp Hypertens,2007,7:243
[17]Gross F,Strassey T.Mild hypertension recent advances In;shkhvatsabaya IkLeft ventricular hypertrophy In mild hypertension New York Raven press Books Ltd,2000,[3]
[18]Gross F,Strasser T.Mild hypertension recent advances. In;Julius S,et al.Pathophysiology of early hypertension;Implication for epidemologic research New York Raven Press Books Ltd, 2000,219
[19]Bbri T,Mild-moderate primary hypertension and apoliporotein E polymorphism [J] Hypertension,2003,15(sup4):s151.
[20]Morisawa T.Kishimoto Y,Kitano M,et al.Influence of angiotensin II type Irecepor polymorphism on hypertension in patients with hypercholesrolemia.Clin Chim Acta,2001,304:91.
[21]LiD,Saldeen T,Romeo F.et at.Qxidized LDL upregulates angiotesin II type 1 recepor expression in cultured human cornary artery endothelial cells:the potential role of transcription factor NF-KB.Circulation,2000,102:1970.
[22]PalatiniD. Heart rate as a cardiovascular risk factor. Hcart J,1999,1 (supple ments B): 133.
[23]Lund-Jehansen P. Blood pressure and heart rate responses during physical stress in hypertension :Moditications by drug treatment. [J]Eur Heart J,1999, 1(supplenemt B):1310.
[24]Tell GS, Rutan GH, Kronmal RA, et al. Correlates of blood pressure incommunity-dwelling older adults. The Cardiovascular Health Study. [J]Hypertension,1994.23:59.
[25]Bonaa KH, Amesent. Association between heart rate and atherogenic blood lipid fractions in a population. The Tromso Study. [J]Circulation,1992,86:394-405.
[26]Cohn JN. A bno rmalities of peripheral sympathetic nervous systemcontro 1 in congestive heart failure. Circulation,1990,82 (Supp 1):
[27]丁翊.华泽惠.高血压病,冠心病患者与正常人QT离散度、心率变异指标的对比研究.临床心电学杂志,2001,10(1)：29-30.
[28]Reaven GM. Bantin R. Role of insulin resistance in human disease. Diabetes.1988.37: 159
[29]梁立荣,李新立,许迪,等.不同血压亚临床血管病变的特点及其临床意义[J].南京医科大学学报(自然科学版),2005,25：101-104.
[30]Cohn JN. Arterial stiffness, vascular disease, and risk of cardiovas2cular events[J] Circulation,2006,113:601-603
[31]Gschwend S, Pinto2Sietsma SJ, Buikema H,et al. Impaired coronaryendothelial function in a rat model of spontaneous albuminuria [J].Kidney Int,2002,62:181-191.
[32]Cirillo M, Stellato D, Laurenzi M, et al. Pulse pressure and isolatedsystolic hypertension: association with microalbuminuria. The GUB-BIO Study Collaborative Research Group[J] Kidney Int,2000,62:1211-1218.
[33]丁凤萍,张明.高血压前期与血尿酸及血脂相关性调查.心血管康复医学杂志2007,3：312-313.
[34]Cupeper WS 3d,et al.Cardiac stalus in juvenile borderline hyperension.Annlnlern Med,2003,98:1
[35]彭健.高血压与血脂代谢紊乱[J].中国实用内科杂志,2002,22(4)：202.
[2]《中国高血压防治指南》修订委员会[M]／／刘力生,龚兰生.《中国高血压防治指南》,2005年修订版.人民卫生出版社.
[3]Chobanian AV,Bakris GL,Black HR,et al. The Seventh Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure:the JNC-7 report. JAMA,2003,289:2560-2572.
[4]Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D. Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study:a cohort study. Lancet.2001; 358:1682-1686.
[5]Qureshi AI,Suri MFK,Kirmani J F,et al.Is prehypertension a risk factor for cardiovascular disease [J].Stroke,2005,36;1859-1863.
[6]WILL IAMS B,POUL TER N,BROWN M,et al. British Hypertension Society guidelines for hypertension management 2004(BHS-IV):summary[J]. BMJ,2004,328:634-640.
[7]陈捷,赵秀丽,武峰,等.我国14省市中老年人肥胖超重流行现状及其与高血压患病率的关系[J].中华医学杂志,2005,85：2830-2834.
[8].孙佳艺,赵冬,王薇.北京地区2740人的血压水平10年(1992-2002)变化情况[J].高血压杂志,2005,13：115-119.
[9]Bautista LE, Lopez-Jaramillo P,Vera LM, et al. Is C-reactive protein an independent risk factor for essential hypertension [J].J.Hypertens,2001; 19.
[10]Jae, Sae Young PhD; Fernhall, Bo PhD; Lee, Miyoung MS;et,al Exaggerated Blood Pressure Response to Exercise is Associated With Inflammatory Markers.2006 Lippincott Williams& Wilkins, Inc. Volume 26(3), May/June 2006, pp 145-149.
[11]Mancia G,De Backer G, Dom in iczak A, et al 2007 guidelines for the management of arterial hypertension:The task force for the managent of arterial hypertension of the European society of hypertension(ESH) and of the European society of cardiology(ESC). J Hypertens, 2007,25(6):1105-1187.
[12]王薇,赵冬,孙佳艺,等.中国正常高值血压人群的心血管病发病危险.中华高血压杂志,2007,15(12)：984-987.
[13]J Vasan RS, Larson MG, Leip EP, et al. Impact of high, nomal blood pressure on the risk of cardiovascular disease. N Erl91 J Med,2001,345(18):1291-1297.
[14]Zhang Y, Lee ET, Devereux RB, et al. Prehypertension, diabetes, and cardiovascular disease risk in a population. based sample:the stmng heart study. Hypertension,2006,47(3): 410-414.
[15]Liszka HA, Mainous III AG, King DE, et al.Prehypertension and cardiovascular morbidity. Ann Fam Med,2005,3(4):294-299.
[16]Kshirsagar AV, Carpenter M, Bang H, et al. Blood pressure usually considered normal is associated with an elevated risk of cardiovascular disease. Am J Med,2006,119(2):133-141.
[17]Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality:a meta-analysis of individual data for one million adults in 61 prosuective studies.[J] Lancet,2002,360(9349):1903-1913.
[18]Mainous AG, Everett CJ, Liszka H, et al. Prehypertension and mortality in a nationally representative cohort[J]. Am J Cardiol,2004,94(12):1496-1500.
[19]Russell LB, Valiyeva E, Carson JL. Effects of prehypertension on admissions and deaths:a simulation. [J]Arch Intern Med,2004,164(19):2119-2124.
[20]赵冬,王薇,刘静,等.正常高值血压人群10年心血管病发病危险的分析.中华老年脑血管病杂志,2006,8(11)：730-733.
[21]Washio M, Tokunaga S, Yoshimasu K, et al. Role of prehypertension in the development of coronary athemsclerosis inJapan. [J] Epidemiol,2004,14(2):57-62.
[22]Chrysohoou C, Pitsavos C, Panagiotakos DB, et al. Association between prehypertension status and inflammatory markers related to atherosclerotic disease:the ATTICA study. Am[J] Hvpertens,2004,17(7):568-573.
[23]Clansen P, JenserI J. S, Jensen J, et al. Elevated urjnary albuminexcretion is associated with impaired arterial dilatory capacity in clinically healthy slects[J]. Circulation,2001,103: 1869-1874.
[24]Jay PG, Geoge LB. Microalbuminuria:marker of vascular dysfunction, risk factorfor cardiovascular disease [J]. Vascular medicine,2002,7:35-43.
[25]Roberto Pedrinelli, Giulia Dell'Omo, Vitantonio Di Bello, et al. Low-Grade Inflammation and Microalbuminuria in Hypertension [J]. Arteriosclerosis, Thrombosis, and Vascular Biolog, 2004,24:2414.
[26]Hashimoto H, Kitagawa K, Hougaku H, et al. Relationship between C-reactive protein and progression of early carotidatherosclerosis in hypertensive subjects [J].Stroke,2004,35:1625-1630.
[27]Teoh H, Quan A, Leung SW. Diffirential effects of 17 betaestrodio 1 and testosterone on the contractile responses of porcine coronary arteries [J]. Br J Pharmacol,2000,129:1301-1308.
[28]Dubey RK, Jackson EK, Gillespie DG, et al. Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity[J]. A-rterioscler Thromb V asc Bio l,2000,20:964-972.
[29]GordonM S, Chin WW, Shupnik MA. Regulation of angio tensinogen gene expression by estrogen [J], J Hypertens,1992,10:361-366.
[1]Prospective Studies Collaboration. Agespecific relevance of usual blood pressure to vascular mortality:a metaanalysis of individual data for one million adults in 61 prospective studies[J].Lancet,2002,360:1903-1913.
[2]王薇,赵冬,刘静,等.中国35-64岁人群血压水平与10年心血管病发病危险的前瞻性研究[J].中华内科杂志,2004,43：7302734.
[3]Chobanian AV, Bakris GL, Black HR, et al. National heart,lung and blood institute joint national committee on prevention,detection, evaluation, and treatment of high blood pressure;national high blood pressure education program coordinating committee. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure:the JNC 7 report [J]. JAMA,2003,289:2560-2572
[4]《中国高血压防治指南》修订委员会[M]／／刘力生,龚兰生.《中国高血压防治指南》,2005年修订版.人民卫生出社.n
[5]j Gu D, Wildman RP, Wu X, et al. Incidence and predictors of hypertension over 8 years among Chinese men and women. [J]Hypertens,2007,25(3):517-523.
[6]Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and st-roke,13000 stroke in 450000 people in 45 prospective cohort s[J]. Lancet; 1995:346:1647-1655.
[7]Eastern Stroke and Coronary Heart Disease Collaborative Research Group. Blood pressure cholesterol and stroke in eastern Asia [J]. Lancet; 1999,352:1801-1807.
[8]王薇,赵冬,刘静,等.中国35-64岁人群血压水平与10年心血管病发病危险的前瞻性研究[J].高血压杂志,2004,12：S829.
[9]Vasan RS, Larson MG, Leip EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease[J]. N Engl J Med,2001,345:1291-1297.
[10]Adler AI, St raton IM, Neil HAW, et al. Association of systolic blood pressure wit h-macrovascular and microvascular complication of type 2 diabetes (U KPDS 36):prospective observationalstudy[J]. BMJ,2000,321:412-419.
[11]国家“十五”攻关冠心病、脑卒中综合危险因素危险度评估及干预研究课题组(武阳丰).国人缺血性心血管病发病危险的评估方法及简易评估工具的开发研究[J].中华心血管病杂志,2003,31：893-901.
[12]J Vasan RS, Larson MG, Leip EP, et al. Assessent of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study:a cohort study [J]Lancet,2001,358(9294):1682-1686.
[13]WaIlg Y, Wang QJ. The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines:new challenges of the old problem [J]Arch Intern Med,2004,164(19):2126-2134.
[14]赵冬,王薇,刘静,等.正常高值血压人群10年心血管病发病危险的分析.[J]中华老年脑血管病杂志,2006,8(11)：730-733.
[15]Julius S, Nesbitt SD, Egan BM, et al. Feasibility of treating hypertension with an angiotensin-receptor blocker. N Engl [J]Med,2006,354(16):1685-1697.
[16]Eager B Julius S.Vascular hypertrophy in borderline hypertension Relationship to blood pressure and sympathetic drive, Clin Exp Hypertens,2007,7:243
[17]Gross F,Strassey T.Mild hypertension recent advances In;shkhvatsabaya IkLeft ventricular hypertrophy In mild hypertension New York Raven press Books Ltd,2000,[3]
[18]Gross F,Strasser T.Mild hypertension recent advances. In;Julius S,et al.Pathophysiology of early hypertension;Implication for epidemologic research New York Raven Press Books Ltd, 2000,219
[19]Bbri T,Mild-moderate primary hypertension and apoliporotein E polymorphism [J] Hypertension,2003,15(sup4):s151.
[20]Morisawa T.Kishimoto Y,Kitano M,et al.Influence of angiotensin II type Irecepor polymorphism on hypertension in patients with hypercholesrolemia.Clin Chim Acta,2001,304:91.
[21]LiD,Saldeen T,Romeo F.et at.Qxidized LDL upregulates angiotesin II type 1 recepor expression in cultured human cornary artery endothelial cells:the potential role of transcription factor NF-KB.Circulation,2000,102:1970.
[22]PalatiniD. Heart rate as a cardiovascular risk factor. Hcart J,1999,1 (supple ments B): 133.
[23]Lund-Jehansen P. Blood pressure and heart rate responses during physical stress in hypertension :Moditications by drug treatment. [J]Eur Heart J,1999, 1(supplenemt B):1310.
[24]Tell GS, Rutan GH, Kronmal RA, et al. Correlates of blood pressure incommunity-dwelling older adults. The Cardiovascular Health Study. [J]Hypertension,1994.23:59.
[25]Bonaa KH, Amesent. Association between heart rate and atherogenic blood lipid fractions in a population. The Tromso Study. [J]Circulation,1992,86:394-405.
[26]Cohn JN. A bno rmalities of peripheral sympathetic nervous systemcontro 1 in congestive heart failure. Circulation,1990,82 (Supp 1):
[27]丁翊.华泽惠.高血压病,冠心病患者与正常人QT离散度、心率变异指标的对比研究.临床心电学杂志,2001,10(1)：29-30.
[28]Reaven GM. Bantin R. Role of insulin resistance in human disease. Diabetes.1988.37: 159
[29]梁立荣,李新立,许迪,等.不同血压亚临床血管病变的特点及其临床意义[J].南京医科大学学报(自然科学版),2005,25：101-104.
[30]Cohn JN. Arterial stiffness, vascular disease, and risk of cardiovas2cular events[J] Circulation,2006,113:601-603
[31]Gschwend S, Pinto2Sietsma SJ, Buikema H,et al. Impaired coronaryendothelial function in a rat model of spontaneous albuminuria [J].Kidney Int,2002,62:181-191.
[32]Cirillo M, Stellato D, Laurenzi M, et al. Pulse pressure and isolatedsystolic hypertension: association with microalbuminuria. The GUB-BIO Study Collaborative Research Group[J] Kidney Int,2000,62:1211-1218.
[33]丁凤萍,张明.高血压前期与血尿酸及血脂相关性调查.心血管康复医学杂志2007,3：312-313.
[34]Cupeper WS 3d,et al.Cardiac stalus in juvenile borderline hyperension.Annlnlern Med,2003,98:1
[35]彭健.高血压与血脂代谢紊乱[J].中国实用内科杂志,2002,22(4)：202.