述情障碍者的静息状态功能磁共振研究
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摘要
目的:利用局部一致性(regional homogeneity,ReHo)方法分析述情障碍者在静息状态下的功能磁共振成像(functional magneticresonance imaging,fMRI)数据,探讨述情障碍者在静息状态下是否存在脑功能异常及其区域。
方法:采用多伦多述情障碍20个条目量表(TAS-20)在女大学生中筛选出述情障碍者和非述情障碍者各18人,进行静息状态下的fMRI检查,并利用ReHo方法(评估局部BOLD信号在同一时间序列中的相似性)处理每个人的fMRI数据。比较述情障碍者和非述情障碍者在静息状态下全脑功能活动的ReHo差异。
结果:与非述情障碍者相比,述情障碍者静息状态下脑的BOLD信号的ReHo普遍增高(p＜0.05)。ReHo增高的脑区广泛分布于左侧枕叶、楔叶、楔前叶、右额叶、中央前回、额下回、左侧的舌回和右侧顶叶。
结论:述情障碍者在静息状态下即可能存在广泛分布的脑区功能异常,ReHo方法可能有助于述情障碍静息状态脑功能的理解。
Objective: To detecting whether the abnormal brain activity exists in resting state of alexithymics by using a regional homogeneity(ReHo) approach in analyzing functional magnetic resonance imaging(fMRI) datasets.
Methods: 18 alexithymics and 18 non-alexithymics were screened out in female students ,fMRI images were obtained in resting state from 15 alexithymics and 15 nonalexithymics. The newly Published ReHo approach (which estimates the temporal homogeneity of regional BOLD signal in the same time series)was applied to Preprocess the fMRI datasets(K=27).For exploring the ReHo diference between the alexithymics and nonalexithymics, a two-sample t test was performed on the individual ReHo maps in a voxel-by-voxel maner. Resulted statistical map was set at a combined threshold of p<0.01 and aminimum cluster size greater than 30 voxels, which resulted in a corrected threshold of p<0.05.
Results: Compared with nonalexithymics, alexithymics showed increased ReHo of blood oxygen level dependent(BOLD)signal in resting brain (p<0.05).The decreased ReHo is distributed over left occipital lobe, left cuneus, left precuneus, left lingual gyrus and right frontal lobe, right middle frontal, right gyrus, right frontal Lobe, right inferior frontal gyrus and right precuneus.
Conclusion: The resting state fMRI stuty showed that abnormal brain activity of alexithymics might exist in resting state. The ReHo may be potentially helpful in understanting resting state of alexithymics.
方法:采用多伦多述情障碍20个条目量表(TAS-20)在女大学生中筛选出述情障碍者和非述情障碍者各18人,进行静息状态下的fMRI检查,并利用ReHo方法(评估局部BOLD信号在同一时间序列中的相似性)处理每个人的fMRI数据。比较述情障碍者和非述情障碍者在静息状态下全脑功能活动的ReHo差异。
结果:与非述情障碍者相比,述情障碍者静息状态下脑的BOLD信号的ReHo普遍增高(p＜0.05)。ReHo增高的脑区广泛分布于左侧枕叶、楔叶、楔前叶、右额叶、中央前回、额下回、左侧的舌回和右侧顶叶。
结论:述情障碍者在静息状态下即可能存在广泛分布的脑区功能异常,ReHo方法可能有助于述情障碍静息状态脑功能的理解。
Objective: To detecting whether the abnormal brain activity exists in resting state of alexithymics by using a regional homogeneity(ReHo) approach in analyzing functional magnetic resonance imaging(fMRI) datasets.
Methods: 18 alexithymics and 18 non-alexithymics were screened out in female students ,fMRI images were obtained in resting state from 15 alexithymics and 15 nonalexithymics. The newly Published ReHo approach (which estimates the temporal homogeneity of regional BOLD signal in the same time series)was applied to Preprocess the fMRI datasets(K=27).For exploring the ReHo diference between the alexithymics and nonalexithymics, a two-sample t test was performed on the individual ReHo maps in a voxel-by-voxel maner. Resulted statistical map was set at a combined threshold of p<0.01 and aminimum cluster size greater than 30 voxels, which resulted in a corrected threshold of p<0.05.
Results: Compared with nonalexithymics, alexithymics showed increased ReHo of blood oxygen level dependent(BOLD)signal in resting brain (p<0.05).The decreased ReHo is distributed over left occipital lobe, left cuneus, left precuneus, left lingual gyrus and right frontal lobe, right middle frontal, right gyrus, right frontal Lobe, right inferior frontal gyrus and right precuneus.
Conclusion: The resting state fMRI stuty showed that abnormal brain activity of alexithymics might exist in resting state. The ReHo may be potentially helpful in understanting resting state of alexithymics.
引文
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3 Bermond B.Alexithymie,een neuropsychologische benadering(Alexithymia,a neuropsychological method of approach).Tijdschr Psychiatr(J Psychiatry),1995,37:717-727.
4 Bagby RM,Parker JD,Taylor GJ.The twenty-item Toronto Alexithymia Scale-Ⅰ.Item selection and cross-validation of the factor structure.Journal of psychosomatic research,1994,38:23-32.
5 Bagby RM,Taylor GJ,Parker JD.The Twenty-item Toronto Alexithymia Scale-Ⅱ.Convergent,discriminant,and concurrent validity.Journal of psychosomatic research,1994,38:33-40.
6 蚁金瑶,姚树桥,朱熊兆等.TAS-20中文版的信度、效度分析.中国心理卫生杂志,2003,17(11):763-767.
7 Hoppe KD.Split brains and psychoanalysis.The Psychoanalytic quarterly,1977,46:220-44.
8 Mark Connelly,Douglas R.Regulation of emotions during experimental stress in alexithymia.Journal of Psychosomatic Research,2007,62:649-659
9 Taylor GJ.Recent developments in alexithymia theory and research.Can J Psychiatry,2000,45:134-142.
10 Parker JD,Taylor GJ,Bagby RM.Alexithymia and the recognition of facial expressions of emotion.Psychotherapy and psychosomatics,1993,59:197-202.
11 Lane RD,Ahern GL,Schwartz GE.et al.Is alexithymia the emotional equivalent of blindsight?.Biological psychiatry,1997,42:834-44.
12 Gazzaniga MS.Organization of the human brain.Science(New York,N.Y.),1989,245:947-52.
13 Gazzaniga,M.and LeDoux,JE,The integrated mind..New York:Plenum,1978
14 Gainotti,G.,Caltagirone,C.and Zoccolotti,P.left/right and cortical/subcortical dichotomies in the neuropsychological study of human emotions.Cognition and Emotion.Cogn Emot.,1993,7(1):71-93.
15 Bear DM.Hemispheric specialization and the neurology of emotion.Archives of neurology,1983,40:195-202.
16 Hoppe KD.Hemispheric specialization and creativity.The Psychiatric clinics of North America,1988,11:303-15.
17 Larsen JK,Brand N,Bermond B.et al.Cognitive and emotional characteristics of alexithymia:a review of neurobiological studies.Journal of psychosomatic research,2003,54:533-41.
18 Mandal MK,Borod JC,Asthana HS.et al.Effects of lesion variables and emotion type on the perception of facial emotion.The Journal of nervous and mental disease,1999,187:603-9.
19 Cicero BA,Borod JC,Santschi C.et al.Emotional versus nonemotional lexical perception in patients with right and left brain damage.Neuropsychiatry,neuropsychology,and behavioral neurology,1999,12:255-64.
20 Borod JC,Cicero BA,Obler LK.et al.Right hemisphere emotional perception:evidence across multiple channels.Neuropsychology,1998,12:446-58.
21 McDonald PW,Prkachin KM.The expression and perception of facial emotion in alexithymia:a pilot study.Psychosomatic medicine,1990,52:199-210.
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