牦牛胚胎裙毛毛囊形态发生及其β-catenin和Sonic hedgehog的表达规律
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摘要
选取牦牛作为极端生态环境动物毛囊发育的研究模型,通过常规组织切片和组织芯片技术、HE和胶原染色对Ed 35～255牦牛被皮毛囊形态发生过程进行了系统地观察分析,着重研究牦牛裙毛毛囊的形态发生特点,并通过免疫组织化学方法对β-catenin和SHH(Sonic hedgehog)在裙毛毛囊形态发生过程中的表达规律进行了检测分析,结果发现:
1.牦牛被皮毛囊的形态发生均经历了基板前期、基板期、毛芽期、毛钉期和毛囊期5个主要时期,各时期又可分为几个亚期,特别是基板期可划分为4个亚期。牦牛裙毛毛囊形态发生时间较其它区域早,且密度较大,合成胶原量多;
2.附着在牦牛成熟被皮毛囊上的汗腺和皮脂腺,与毛囊形态发生相伴随。汗腺的形态发生经历了基板期、芽期、钉期和成熟期。皮脂腺由毛囊上段细胞分化增殖形成,最终形成典型的毛囊—汗腺—皮脂腺单位;
3.β-catenin在牦牛被皮毛囊形态发生的基板前期和基板期表皮和间充质细胞均高表达,在毛芽期、毛钉期表达减弱,毛囊期强表达于毛球的毛母质区域,毛乳头区域则很弱;β-catenin在裙毛毛囊基板前期和基板期表皮-间充质表达强于其它区域;
4. SHH在牦牛被皮毛囊形态发生的基板前期和基板期强表达于表皮基底层细胞,间充质细胞不表达,在毛芽期和毛钉期表皮—间充质均不表达,在毛囊期出现于毛囊部分表皮细胞和毛乳头;SHH在裙毛毛囊基板前期和基板期表皮-间充质表达呈上升趋势。
The study selected Bos grunniens embryo as hair follicle developmental model under extreme ecological environment. We systematically analysis hair follicle morphogenesis in Bos grunniens embryos during Ed 35 ~ 255 by conventional histological section, tissue microarray technology, HE and collagen staining . And the expression pattern of signaling moleculeβ-catenin and SHH(sonic hedgehog) were detected by immunohistochemistry. The results showed that:
1. Morphogenesis of Bos grunniens hair follicle can be divided into pre-placode stage, hair placode stage, hair germ stage, hair peg stage and hair follicle stage by morphological changes. And these stages can be divided into several sub-stages, in particular, the hair placode stage can be divided into four sub-stages. Bos grunniens macrotrichium follicles occur earlier than the other pelage follicles and also get higher density and more synthesis of collagen.
2. Bos grunniens hair follicle morphogenesis is accompanied by the occurrence of sweat gland and sebaceous gland. After stage of placode, germ, peg, shaping and differentiation, sweat gland mature. And sebaceous gland has also experienced a period of morphogenesis stage, cell differentiation stage and maturation stage before the maturity. Eventually a typical hair follicle - sweat gland - sebaceous unit form.
3. At the pre-plcode stage,β-catenin expressed in the epidermal keratinocytes and dermal mesenchymal cells, At the hair placode stage,β-catenin strongly expressed in the epidermis of placode and dermal condensate. After a expression decrease during hair germ and peg stage,β-catenin again expressed in the hair matrix region at the hair follicle stage.
4. At the pre-placode stage, SHH expressed in the epidermal basal cells. After the formation of hair placode SHH expressed in the epithelial department of placode. Then at the hair germ stage, SHH expressed in anterior extremity of the epithelial cord before a transient expression disappearance until hair follicle stage. After hair follicle form and begin differentiation and maturation, SHH was seen again in the hair follicle root sheath, sebaceous gland cells, hair matrix and dermal papilla region.
1.牦牛被皮毛囊的形态发生均经历了基板前期、基板期、毛芽期、毛钉期和毛囊期5个主要时期,各时期又可分为几个亚期,特别是基板期可划分为4个亚期。牦牛裙毛毛囊形态发生时间较其它区域早,且密度较大,合成胶原量多;
2.附着在牦牛成熟被皮毛囊上的汗腺和皮脂腺,与毛囊形态发生相伴随。汗腺的形态发生经历了基板期、芽期、钉期和成熟期。皮脂腺由毛囊上段细胞分化增殖形成,最终形成典型的毛囊—汗腺—皮脂腺单位;
3.β-catenin在牦牛被皮毛囊形态发生的基板前期和基板期表皮和间充质细胞均高表达,在毛芽期、毛钉期表达减弱,毛囊期强表达于毛球的毛母质区域,毛乳头区域则很弱;β-catenin在裙毛毛囊基板前期和基板期表皮-间充质表达强于其它区域;
4. SHH在牦牛被皮毛囊形态发生的基板前期和基板期强表达于表皮基底层细胞,间充质细胞不表达,在毛芽期和毛钉期表皮—间充质均不表达,在毛囊期出现于毛囊部分表皮细胞和毛乳头;SHH在裙毛毛囊基板前期和基板期表皮-间充质表达呈上升趋势。
The study selected Bos grunniens embryo as hair follicle developmental model under extreme ecological environment. We systematically analysis hair follicle morphogenesis in Bos grunniens embryos during Ed 35 ~ 255 by conventional histological section, tissue microarray technology, HE and collagen staining . And the expression pattern of signaling moleculeβ-catenin and SHH(sonic hedgehog) were detected by immunohistochemistry. The results showed that:
1. Morphogenesis of Bos grunniens hair follicle can be divided into pre-placode stage, hair placode stage, hair germ stage, hair peg stage and hair follicle stage by morphological changes. And these stages can be divided into several sub-stages, in particular, the hair placode stage can be divided into four sub-stages. Bos grunniens macrotrichium follicles occur earlier than the other pelage follicles and also get higher density and more synthesis of collagen.
2. Bos grunniens hair follicle morphogenesis is accompanied by the occurrence of sweat gland and sebaceous gland. After stage of placode, germ, peg, shaping and differentiation, sweat gland mature. And sebaceous gland has also experienced a period of morphogenesis stage, cell differentiation stage and maturation stage before the maturity. Eventually a typical hair follicle - sweat gland - sebaceous unit form.
3. At the pre-plcode stage,β-catenin expressed in the epidermal keratinocytes and dermal mesenchymal cells, At the hair placode stage,β-catenin strongly expressed in the epidermis of placode and dermal condensate. After a expression decrease during hair germ and peg stage,β-catenin again expressed in the hair matrix region at the hair follicle stage.
4. At the pre-placode stage, SHH expressed in the epidermal basal cells. After the formation of hair placode SHH expressed in the epithelial department of placode. Then at the hair germ stage, SHH expressed in anterior extremity of the epithelial cord before a transient expression disappearance until hair follicle stage. After hair follicle form and begin differentiation and maturation, SHH was seen again in the hair follicle root sheath, sebaceous gland cells, hair matrix and dermal papilla region.
引文
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