分化抑制因子2在先天性肾盂输尿管连接部梗阻中的表达
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摘要
研究目的：探讨先天性肾盂输尿管连接部梗阻(UPJO)患儿肾盂输尿管连接部组织中分化抑制因子2 (Id2) mRNA的表达情况。
材料与方法：收集20例接受肾盂成形术的UPJO患儿的肾盂输尿管连接部组织作为病例组,10例对照组标本来自肾母细胞瘤中无肿瘤转移的肾盂输尿管组织。依据组织部位不同,将UPJO组分为扩张肾盂、狭窄段及狭窄段下正常输尿管三组；对照组分为肾盂和输尿管两组。用半定量反转录-PCR (RT-PCR)检测Id2 mRNA在不同组间的表达水平,并采用独立样本t检验和单因素方差分析方法对各组Id2 mRNA表达水平进行分析。
研究结果：UPJO组：Id2 mRNA在扩张肾盂、狭窄段输尿管的表达差异无统计学意义(P>0.05),而这两组与狭窄段下正常输尿管比较均有降低,差异有统计学意义(P<0.05)；对照组：肾盂和输尿管Id2 mRNA表达差异无统计学意义(P>0.05); UPJO组与对照组比较：Id2 mRNA在UPJO组扩张肾盂、狭窄段输尿管中的表达,与对照组中肾盂、输尿管比较,表达降低,差异均有统计学意义(P<0.05),而UPJO组狭窄段下正常输尿管与对照组肾盂和输尿管Id2 mRRNA表达差异均无统计学意义(P>0.05)。
研究结论：Id2基因可能与UPJO的发病有关。
Purpose:To explore the mRNA expression of inhibitor of differentiation 2 (Id2) in ureteropelvic junction tissue with congenital ureteropelvic junction obstruction (UPJO) in children.
Material and Methods:Twenty cases with UPJO and 10 cases with Wilms'tumor without invading into ureteropelvic junction tissue as control group were collected. UPJO were categorized into three groups:renal pelvis dilation, narrow ureter and normal ureter below narrow ureter according to their locations. Control was divided into two groups:renal pelvis and ureter. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of mRNA in these tissues. All the data were analysed by t-test and one-way anova.
Results:UPJO:No significant difference of the Id2 mRNA expression was observed between renal pelvis dilation and narrow ureter in UPJO (P>0.05), and we found that their expressions were lower than the normal ureter below narrow ureter in UPJO(P<0.05). Control group:the renal pelvis and ureter were similar (P>0.05). UPJO and control group:the Id2 mRNA expression of renal pelvis dilation and narrow ureter in UPJO was lower than renal pelvis and ureter in control group (P<0.05).but the Id2 mRNA expression of the normal ureter below narrow ureter in UPJO was similar to that of renal pelvis or ureter in control group (P>0.05).
Conclusions:The Id2 gene may play an important role in congenital UPJO.
材料与方法：收集20例接受肾盂成形术的UPJO患儿的肾盂输尿管连接部组织作为病例组,10例对照组标本来自肾母细胞瘤中无肿瘤转移的肾盂输尿管组织。依据组织部位不同,将UPJO组分为扩张肾盂、狭窄段及狭窄段下正常输尿管三组；对照组分为肾盂和输尿管两组。用半定量反转录-PCR (RT-PCR)检测Id2 mRNA在不同组间的表达水平,并采用独立样本t检验和单因素方差分析方法对各组Id2 mRNA表达水平进行分析。
研究结果：UPJO组：Id2 mRNA在扩张肾盂、狭窄段输尿管的表达差异无统计学意义(P>0.05),而这两组与狭窄段下正常输尿管比较均有降低,差异有统计学意义(P<0.05)；对照组：肾盂和输尿管Id2 mRNA表达差异无统计学意义(P>0.05); UPJO组与对照组比较：Id2 mRNA在UPJO组扩张肾盂、狭窄段输尿管中的表达,与对照组中肾盂、输尿管比较,表达降低,差异均有统计学意义(P<0.05),而UPJO组狭窄段下正常输尿管与对照组肾盂和输尿管Id2 mRRNA表达差异均无统计学意义(P>0.05)。
研究结论：Id2基因可能与UPJO的发病有关。
Purpose:To explore the mRNA expression of inhibitor of differentiation 2 (Id2) in ureteropelvic junction tissue with congenital ureteropelvic junction obstruction (UPJO) in children.
Material and Methods:Twenty cases with UPJO and 10 cases with Wilms'tumor without invading into ureteropelvic junction tissue as control group were collected. UPJO were categorized into three groups:renal pelvis dilation, narrow ureter and normal ureter below narrow ureter according to their locations. Control was divided into two groups:renal pelvis and ureter. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of mRNA in these tissues. All the data were analysed by t-test and one-way anova.
Results:UPJO:No significant difference of the Id2 mRNA expression was observed between renal pelvis dilation and narrow ureter in UPJO (P>0.05), and we found that their expressions were lower than the normal ureter below narrow ureter in UPJO(P<0.05). Control group:the renal pelvis and ureter were similar (P>0.05). UPJO and control group:the Id2 mRNA expression of renal pelvis dilation and narrow ureter in UPJO was lower than renal pelvis and ureter in control group (P<0.05).but the Id2 mRNA expression of the normal ureter below narrow ureter in UPJO was similar to that of renal pelvis or ureter in control group (P>0.05).
Conclusions:The Id2 gene may play an important role in congenital UPJO.
引文
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