放线菌19G-317菌株及其代谢产物抑菌活性研究
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摘要
本研究以分离自三江源生态环境中的一株放线菌(编号:19G-317)为研究对象,对其农用抑菌活性、生长特性、分类地位、发酵条件、抑菌活性成分的分离与鉴定方面进行了较为系统的研究,得出以下主要研究结果:
1、采用菌丝生长速率法、活体组织法和盆栽试验测定了放线菌19G-317菌株发酵产物的农用抑菌活性。试验结果表明:放线菌19G-317菌株发酵产物(发酵液、菌体提取液和发酵液提取物)不但对22种供试植物病原真菌具有较强的抑菌活性,而且对4种细菌也有一定的抑制作用。菌丝生长速率法试验结果表明,在1 mg/mL浓度下,菌体提取液对8种供试植物病原真菌的菌丝生长抑制率大于90 %;发酵液提取物对11种供试植物病原真菌的菌丝生长抑制率大于90 %。孢子萌发试验结果表明,在5 mg/mL浓度下,发酵产物对番茄灰霉病菌(Botrytis cinerea)、水稻稻瘟病菌(Pyricularia oryzae)、番茄叶霉病菌(Fulvia fulva)孢子萌发的抑制率均大于80 %,发酵液、菌体提取液和发酵液提取物对番茄灰霉病菌孢子萌发的抑制率分别为97.30 %、98.99 %和100%。组织法试验结果表明,在10 mg/mL浓度下,发酵液、菌体提取液和发酵液提取物对番茄灰霉病的药效分别为72.17 %、76.95 %和88.63 %,高于对照药剂(50%速克灵);菌体提取液和发酵液提取物对油菜菌核病(Sclerotinia sclerotiorum)的药效均为100 %。盆栽试验表明,发酵产物对辣椒疫霉病(Phytophthora capsici)、番茄灰霉病、小麦白粉病(Blumeria graminis)、小麦全蚀病(Gaeumannomyces graminis)和小麦纹枯病(Rhizoctonia cerealis)均表现出一定的防治效果。在10 mg/mL浓度下,菌体提取液和发酵液提取物对小麦纹枯病的治疗效果分别为62.40 %和74.08 %;发酵液、菌体提取液和发酵液提取物对小麦白粉病的保护效果分别为63.35 %、59.47 %和71.77 %;发酵液提取物对辣椒疫霉病的保护效果和治疗效果为54.18 %和56.46 %。
2、对放线菌19G-317菌株的生长特性和传代稳定性进行了测定。试验结果表明,该菌株的生长对氧气的需求比较高,属于专性好气型;菌落在pH6.8～8.4的生长环境下生长良好;菌落生长对渗透压的适应范围比较宽,在NaCl质量浓度为0.5～20 g/L的生长环境中均能生长,且生长情况基本一样;菌落生长对紫外线比较敏感,在紫外线照射1 h后,菌落生长明显减弱;菌株的遗传性状在试验范围内保持稳定。
3、根据放线菌19G-317菌株的形态特征、培养特征、生理生化特征以及16S rDNA序列研究结果,初步鉴定该菌株为链霉菌属黄色类群链霉菌。将其16S rDNA序列已注册于GeneBank,注册号为EU872020。
4、综合单因素试验、Plackett–Burman设计和响应面等方法对放线菌19G-317菌株发酵工艺进行了优化。放线菌19G-317菌株优化后的发酵培养基组成为:麦芽糖50.3 g/L、胰蛋白胨9.6 g/L、NaCl 2.5 g/L、CaCO3 2.0 g/L;优化后的揺瓶发酵条件为:装液量125 mL/250mL、转速195 r/min、温度28℃、接种量7 %、初始pH 7。
5、对放线菌19G-317菌株的发酵产物稳定性和发酵培养特性进行了测定。结果表明,该菌株发酵产物对热(20-100℃)比较稳定,对酸碱和紫外线的稳定性较差。发酵液随着处理温度的升高和处理时间的延长对番茄灰霉病菌和枯草芽孢杆菌的抑制率略有下降,下降幅度不明显;发酵液在偏酸或偏碱条件下对番茄灰霉病菌和枯草芽孢杆菌的抑制率均明显低于中性条件(pH 7);紫外线照射45 min后,发酵液对番茄灰霉病菌和枯草芽孢杆菌的抑菌活性与照射5 min的抑菌活性相比,抑制率分别下降30.83 %、8.7 %。发酵培养特性研究结果表明菌株的生长符合微生物生长的一般规律,在0～48 h为生长延缓期,在48～72 h为对数生长期,培养72 h后菌株生长达到稳定期,168 h后进入衰亡期。
6、从放线菌19G-317菌株发酵产物中分离纯化出14个化合物,最终确定出8个化合物结构,分别为1-甲基-9-羟甲基吩嗪(1-methyl-9-hydroxymethylphenazin)(A),β-谷甾醇(β-Sitosterol) (C),硬脂酸(Stearic acid,D),十六酸乙酯(Ethyl-hexadecanoate,H),4-烯-1,11-(1,5-戊二醇)-癸内酯(J),5-烯-1,18-十八烷二酸二甲酯(K),3,4,6-三乙酸-1-环己烯(L),环(丙氨酰-苯丙氨酸) [cyclo-(Ala-Phe),M]。
试验结果表明,菌株代谢产物的抑菌活性成分主要属于中等极性或高极性物质,对发酵产物分离纯化得到三个活性较好的化合物。这3个化合物(M、N、O)对番茄灰霉病菌和枯草芽孢杆菌均有较好的抑制作用。在1 mg/mL浓度下,3个化合物对枯草芽孢杆菌的抑菌圈直径分别为11 mm、13 mm和19 mm,对番茄灰霉病菌的菌丝生长抑制率分别为59.67%、84.43%和97.88 %,对番茄灰霉病菌的孢子萌发抑制率分别为77.9 %、100.0 %和100.0 %。
In this thesis, a strain of actinomycete (No. 19G-317) isolated from the soil of natural conservation area of Sanjiangyuan Nature Reserve was chose as the main research object, the antifungal activity, the biology characteristics, taxonomic status, fermentation condition optimization, isolation and identified of bioactivity compounds from strain 19G-317 metabolites were studied. The main results and conclusions were outlined as follows:
(1) The fungicidal activities of the fermentation product of actinomycete strain 19G-317 were evaluated by mycelium growth rate, in vivo inhibition and potted plant experiment against plant pathothic fungi and bacteria.The bioassay results showed that both of fermentation broth, extract product of mycelium and fermentation broth not only have stronger bioactivity against 22 tested plant pathogenic fungi, but also have certain inhibition activity against 4 tested plant pathogenic bacteria. The mycelium growth inhibition rate of extract product of actinomycete (No. 19G-317) mycelium were over 90 % to 8 tested plant pathogenic fungi; meanwhile, the mycelium growth inhibition rate of extract product of actinomycete (No. 19G-317) fermentation broth were over 90 % to 11 tested plant pathogenic fungi under the concentration of 1 mg/mL; The results of spore germination test showed that the inhibition rate of the fermentation broth and the extract product of mycelium and the fermentation extraction were 97.30 %、98.99 % and 100.00 % to Botrytis cinerea under the concentration of 5 mg/mL. Tissue experiment showed that the efficacy of the fermentation broth, the extract product of mycelium and the fermentation extraction were 72.17 %、76.95 % and 88.63 % against Botrytis cinerea under the concentration of 10 mg/mL. Furthermore, the control efficacy of the extract product of mycelium and the fermentation extraction were all 100% against Sclerotinia sclerotiorum under the concentration of 10 mg/mL. Potted plant experiment showed that the fermentation products exhibited a protective efficacy of 23.80 %、38.60 %、63.35 % and a therapeutic efficacy of 34.24 %、35.17 %、43.80 % against Phytophthora capsici, Botrytis cinerea and Blumeria graminis, the extract product of mycelium were 43.80 %、47.59 %、59.43 % and 42.74 %、44.57 %、45.09%; The efficacy of the fermentation broth、the extract product of mycelium were 30.60 % and 49.19 %, 45.08 % and 60.42 % against Gaeumannomyces graminis and Rhizoctonia cerealis.
(2) The biology characteristics and passage stability of the strain 19G-317 were determined. The results showed that the growth of the strain 19G-317 need more oxygen, that is, it was aerobic microorganism; the favorite PH value for the strain growth ranged from 6.8 to 8.4, and the optimum PH was 7.6; The osmotic pressure for colony growth of the strain was much broader, it can grow constantly on the concentration of NaCl ranged from 0.5～20 g/L. However, the strain was sensitive to ultraviolet radiation, the colony growth become weaker after 1h ultraviolet radiation; Furthermore, the stability result showed that heredity character of the strain 19G-317 was stable.
(3) Based on morphological characteristics, growth characteristics, biochemical and physiological characteristics and 16S rDNA sequence of the strain 19G-317, it was identified as Streptomyces flavus sp. The 16s rDNA sequences have been deposited in GenBank with the accession numbers EU872020.
(4) Statistical methods such as Single factor, Plackett–Burman design and response surface methodology were employed synthetically to optimize the fermentation medium and conditions of actinomycete strain 19G-317. The optimum composition of the fermentation medium (g/L): Maltose 50.8 g/L、Tryptone 10.5 g/L、NaCl 2.5 g/L、CaCO3 2.0 g/L;and the optimum fermentation condition: medium volume 125mL/250mL、rotary speed 195 r/min、temperature 28℃、inoculation volume 7 %、initial PH 7。After optimization, the antibiotic activity of strain 19G-317 improved by 22.67 % and 38.30 % against Botrytis cinerea and Bacillus subtilis, respectively.
(5) Stability test of fermentation products of strain 19G-317 had been carried out to acid, alkali, temperature and ultraviolet radiation. The fermentation products of strain 19G-317 were stable to temperature, but it was not stable to acid, alkali and ultraviolet radiation. The inhibition rate of fermentation products of strain 19G-317 against Botrytis cinerea and Bacillus subtilis continued to adjust downwards, in line with the rising temperature and extended handling time. The inhibition rate of fermentation products of strain 19G-317 against Botrytis cinerea and Bacillus subtilis under acidic or alkali conditions were lower obviously than under neutral conditions. After 45 min ultraviolet radiation, the inhibition rate of fermentation products of strain 19G-317 against Botrytis cinerea and Bacillus subtilis decreased by 30.83 %、8.7 % than that 5 min ultraviolet radiation. Furthermore, study on the culture characteristics of strain 19G-317showed that the strains growth was in accordance with the general discipline of microorganism growth.
(6) 14 compounds were isolated from fermentation products of strain 19G-317 and the chemical structures of 8 compounds were identified. Those chemicals include 1-methyl-9-hydroxymethylphenazin (A),β-Sitosterol (C), stearic acid(D) ,Ethyl-hexadecanoate(H), 4- alkene -1,11-(1,5-pentadiol)- Decalactone(J), 5- alkene -1,18- Octadecane diacid, dimethyl ester(K), 3,4,6- triacetic acid -1- cyclohexene(L), cyclo-(Ala-Phe)(M).The bioassay results of the chemicals for the actinomycete strain 19G-317 showed that the main bioactivity components belongs to middle or high polarity compounds, the further bioassay indicated that three compounds(M、N、O) have stronger inhibitory effect on Botrytis cinerea and Bacillus subtilis, the inhibition zone diameter of three compounds were over 11mm against Bacillus subtilis, the inhabition rate were over 59.67 % against mycelium growth of Botrytis cinerea, and over 77.9 % against spore germination of Botrytis cinerea.
1、采用菌丝生长速率法、活体组织法和盆栽试验测定了放线菌19G-317菌株发酵产物的农用抑菌活性。试验结果表明:放线菌19G-317菌株发酵产物(发酵液、菌体提取液和发酵液提取物)不但对22种供试植物病原真菌具有较强的抑菌活性,而且对4种细菌也有一定的抑制作用。菌丝生长速率法试验结果表明,在1 mg/mL浓度下,菌体提取液对8种供试植物病原真菌的菌丝生长抑制率大于90 %;发酵液提取物对11种供试植物病原真菌的菌丝生长抑制率大于90 %。孢子萌发试验结果表明,在5 mg/mL浓度下,发酵产物对番茄灰霉病菌(Botrytis cinerea)、水稻稻瘟病菌(Pyricularia oryzae)、番茄叶霉病菌(Fulvia fulva)孢子萌发的抑制率均大于80 %,发酵液、菌体提取液和发酵液提取物对番茄灰霉病菌孢子萌发的抑制率分别为97.30 %、98.99 %和100%。组织法试验结果表明,在10 mg/mL浓度下,发酵液、菌体提取液和发酵液提取物对番茄灰霉病的药效分别为72.17 %、76.95 %和88.63 %,高于对照药剂(50%速克灵);菌体提取液和发酵液提取物对油菜菌核病(Sclerotinia sclerotiorum)的药效均为100 %。盆栽试验表明,发酵产物对辣椒疫霉病(Phytophthora capsici)、番茄灰霉病、小麦白粉病(Blumeria graminis)、小麦全蚀病(Gaeumannomyces graminis)和小麦纹枯病(Rhizoctonia cerealis)均表现出一定的防治效果。在10 mg/mL浓度下,菌体提取液和发酵液提取物对小麦纹枯病的治疗效果分别为62.40 %和74.08 %;发酵液、菌体提取液和发酵液提取物对小麦白粉病的保护效果分别为63.35 %、59.47 %和71.77 %;发酵液提取物对辣椒疫霉病的保护效果和治疗效果为54.18 %和56.46 %。
2、对放线菌19G-317菌株的生长特性和传代稳定性进行了测定。试验结果表明,该菌株的生长对氧气的需求比较高,属于专性好气型;菌落在pH6.8～8.4的生长环境下生长良好;菌落生长对渗透压的适应范围比较宽,在NaCl质量浓度为0.5～20 g/L的生长环境中均能生长,且生长情况基本一样;菌落生长对紫外线比较敏感,在紫外线照射1 h后,菌落生长明显减弱;菌株的遗传性状在试验范围内保持稳定。
3、根据放线菌19G-317菌株的形态特征、培养特征、生理生化特征以及16S rDNA序列研究结果,初步鉴定该菌株为链霉菌属黄色类群链霉菌。将其16S rDNA序列已注册于GeneBank,注册号为EU872020。
4、综合单因素试验、Plackett–Burman设计和响应面等方法对放线菌19G-317菌株发酵工艺进行了优化。放线菌19G-317菌株优化后的发酵培养基组成为:麦芽糖50.3 g/L、胰蛋白胨9.6 g/L、NaCl 2.5 g/L、CaCO3 2.0 g/L;优化后的揺瓶发酵条件为:装液量125 mL/250mL、转速195 r/min、温度28℃、接种量7 %、初始pH 7。
5、对放线菌19G-317菌株的发酵产物稳定性和发酵培养特性进行了测定。结果表明,该菌株发酵产物对热(20-100℃)比较稳定,对酸碱和紫外线的稳定性较差。发酵液随着处理温度的升高和处理时间的延长对番茄灰霉病菌和枯草芽孢杆菌的抑制率略有下降,下降幅度不明显;发酵液在偏酸或偏碱条件下对番茄灰霉病菌和枯草芽孢杆菌的抑制率均明显低于中性条件(pH 7);紫外线照射45 min后,发酵液对番茄灰霉病菌和枯草芽孢杆菌的抑菌活性与照射5 min的抑菌活性相比,抑制率分别下降30.83 %、8.7 %。发酵培养特性研究结果表明菌株的生长符合微生物生长的一般规律,在0～48 h为生长延缓期,在48～72 h为对数生长期,培养72 h后菌株生长达到稳定期,168 h后进入衰亡期。
6、从放线菌19G-317菌株发酵产物中分离纯化出14个化合物,最终确定出8个化合物结构,分别为1-甲基-9-羟甲基吩嗪(1-methyl-9-hydroxymethylphenazin)(A),β-谷甾醇(β-Sitosterol) (C),硬脂酸(Stearic acid,D),十六酸乙酯(Ethyl-hexadecanoate,H),4-烯-1,11-(1,5-戊二醇)-癸内酯(J),5-烯-1,18-十八烷二酸二甲酯(K),3,4,6-三乙酸-1-环己烯(L),环(丙氨酰-苯丙氨酸) [cyclo-(Ala-Phe),M]。
试验结果表明,菌株代谢产物的抑菌活性成分主要属于中等极性或高极性物质,对发酵产物分离纯化得到三个活性较好的化合物。这3个化合物(M、N、O)对番茄灰霉病菌和枯草芽孢杆菌均有较好的抑制作用。在1 mg/mL浓度下,3个化合物对枯草芽孢杆菌的抑菌圈直径分别为11 mm、13 mm和19 mm,对番茄灰霉病菌的菌丝生长抑制率分别为59.67%、84.43%和97.88 %,对番茄灰霉病菌的孢子萌发抑制率分别为77.9 %、100.0 %和100.0 %。
In this thesis, a strain of actinomycete (No. 19G-317) isolated from the soil of natural conservation area of Sanjiangyuan Nature Reserve was chose as the main research object, the antifungal activity, the biology characteristics, taxonomic status, fermentation condition optimization, isolation and identified of bioactivity compounds from strain 19G-317 metabolites were studied. The main results and conclusions were outlined as follows:
(1) The fungicidal activities of the fermentation product of actinomycete strain 19G-317 were evaluated by mycelium growth rate, in vivo inhibition and potted plant experiment against plant pathothic fungi and bacteria.The bioassay results showed that both of fermentation broth, extract product of mycelium and fermentation broth not only have stronger bioactivity against 22 tested plant pathogenic fungi, but also have certain inhibition activity against 4 tested plant pathogenic bacteria. The mycelium growth inhibition rate of extract product of actinomycete (No. 19G-317) mycelium were over 90 % to 8 tested plant pathogenic fungi; meanwhile, the mycelium growth inhibition rate of extract product of actinomycete (No. 19G-317) fermentation broth were over 90 % to 11 tested plant pathogenic fungi under the concentration of 1 mg/mL; The results of spore germination test showed that the inhibition rate of the fermentation broth and the extract product of mycelium and the fermentation extraction were 97.30 %、98.99 % and 100.00 % to Botrytis cinerea under the concentration of 5 mg/mL. Tissue experiment showed that the efficacy of the fermentation broth, the extract product of mycelium and the fermentation extraction were 72.17 %、76.95 % and 88.63 % against Botrytis cinerea under the concentration of 10 mg/mL. Furthermore, the control efficacy of the extract product of mycelium and the fermentation extraction were all 100% against Sclerotinia sclerotiorum under the concentration of 10 mg/mL. Potted plant experiment showed that the fermentation products exhibited a protective efficacy of 23.80 %、38.60 %、63.35 % and a therapeutic efficacy of 34.24 %、35.17 %、43.80 % against Phytophthora capsici, Botrytis cinerea and Blumeria graminis, the extract product of mycelium were 43.80 %、47.59 %、59.43 % and 42.74 %、44.57 %、45.09%; The efficacy of the fermentation broth、the extract product of mycelium were 30.60 % and 49.19 %, 45.08 % and 60.42 % against Gaeumannomyces graminis and Rhizoctonia cerealis.
(2) The biology characteristics and passage stability of the strain 19G-317 were determined. The results showed that the growth of the strain 19G-317 need more oxygen, that is, it was aerobic microorganism; the favorite PH value for the strain growth ranged from 6.8 to 8.4, and the optimum PH was 7.6; The osmotic pressure for colony growth of the strain was much broader, it can grow constantly on the concentration of NaCl ranged from 0.5～20 g/L. However, the strain was sensitive to ultraviolet radiation, the colony growth become weaker after 1h ultraviolet radiation; Furthermore, the stability result showed that heredity character of the strain 19G-317 was stable.
(3) Based on morphological characteristics, growth characteristics, biochemical and physiological characteristics and 16S rDNA sequence of the strain 19G-317, it was identified as Streptomyces flavus sp. The 16s rDNA sequences have been deposited in GenBank with the accession numbers EU872020.
(4) Statistical methods such as Single factor, Plackett–Burman design and response surface methodology were employed synthetically to optimize the fermentation medium and conditions of actinomycete strain 19G-317. The optimum composition of the fermentation medium (g/L): Maltose 50.8 g/L、Tryptone 10.5 g/L、NaCl 2.5 g/L、CaCO3 2.0 g/L;and the optimum fermentation condition: medium volume 125mL/250mL、rotary speed 195 r/min、temperature 28℃、inoculation volume 7 %、initial PH 7。After optimization, the antibiotic activity of strain 19G-317 improved by 22.67 % and 38.30 % against Botrytis cinerea and Bacillus subtilis, respectively.
(5) Stability test of fermentation products of strain 19G-317 had been carried out to acid, alkali, temperature and ultraviolet radiation. The fermentation products of strain 19G-317 were stable to temperature, but it was not stable to acid, alkali and ultraviolet radiation. The inhibition rate of fermentation products of strain 19G-317 against Botrytis cinerea and Bacillus subtilis continued to adjust downwards, in line with the rising temperature and extended handling time. The inhibition rate of fermentation products of strain 19G-317 against Botrytis cinerea and Bacillus subtilis under acidic or alkali conditions were lower obviously than under neutral conditions. After 45 min ultraviolet radiation, the inhibition rate of fermentation products of strain 19G-317 against Botrytis cinerea and Bacillus subtilis decreased by 30.83 %、8.7 % than that 5 min ultraviolet radiation. Furthermore, study on the culture characteristics of strain 19G-317showed that the strains growth was in accordance with the general discipline of microorganism growth.
(6) 14 compounds were isolated from fermentation products of strain 19G-317 and the chemical structures of 8 compounds were identified. Those chemicals include 1-methyl-9-hydroxymethylphenazin (A),β-Sitosterol (C), stearic acid(D) ,Ethyl-hexadecanoate(H), 4- alkene -1,11-(1,5-pentadiol)- Decalactone(J), 5- alkene -1,18- Octadecane diacid, dimethyl ester(K), 3,4,6- triacetic acid -1- cyclohexene(L), cyclo-(Ala-Phe)(M).The bioassay results of the chemicals for the actinomycete strain 19G-317 showed that the main bioactivity components belongs to middle or high polarity compounds, the further bioassay indicated that three compounds(M、N、O) have stronger inhibitory effect on Botrytis cinerea and Bacillus subtilis, the inhibition zone diameter of three compounds were over 11mm against Bacillus subtilis, the inhabition rate were over 59.67 % against mycelium growth of Botrytis cinerea, and over 77.9 % against spore germination of Botrytis cinerea.
引文
[1]陈建峰.开发生物农药,推动无公害农业发展[J].蔬菜, 2000,8,4-7.
[2]陈建辉,叶正,梁小慧.八五期间我国生物防治技术研究进展[M].中国植物保护研究进展,1996,40-43.
[3]赵继红,李建中.微生物农药杀菌剂研究进展[J].农药,2003,42(5):6-8.
[4]张兴,马志卿,李广泽,等.生物农药评述[J].西北农林科技大学学报, 2002,30 (2):142- 148.
[5]纪明山,谷祖敏,张杨.生物农药研究与应用现状及发展前景[J].沈阳农业大学学报,2006,08,37(4):54-55.
[6]李树正,张素华.杀菌剂筛选方法的研究[J].农药, 1997,36(9):20-22.
[7]李勇等.微生物农药的研究和应用进展[J].贵州农业科学, 2003,31(2):64-66.
[8] Shimizu M, Nakagawa Y, Sato Y, et al. Studies on endophytic actinomycetes ( I ) Streptomyces sp. isolated from rhododendron and its antifungal activity[J]. Journal of General Plant Pathology, 2000,66(4): 360-366.
[9] Nishimura T, Meguro A, Hasegawa S, et al. An endophytic actinomycete, streptomyces sp. AOK-30, isolated from mountain laurel and its antifungal activity[J]. Journal of General Plant Pathology, 2002,68(4): 390-397.
[10]黄世文,高成伟,王玲,等.土壤中有益放线菌的高效分离、筛选和生物测定技术[J].植物保护, 2008,34(1):138-141.
[11]李新,纪明山.土壤中拮抗放线菌的分离和筛选[J].河南农业科学.2008,(1):58-60.
[12]安德荣,穆小倩,刘翠娟,等.土壤拮抗放线菌的分离和筛选[J].微生物学杂志, 2002,22(5):1-3.
[13]周鑫钰,朱宏建,易图永.土壤放线菌生防活性物质的研究进展[J].作物研究, 2007, 21(2):149-151.
[14]刘红艳,张亚莲,包小村,等.茶园土壤拮抗放线菌的分离和筛选[J].湖南农业大学学报(自然科学版),2008(06):701-703.
[15]张炳火,方亮,李汉全,等.微生物资源研究开发进展[J].国外医药:抗生素分册. 2006, 27(5): 233-235.
[16]朱红建.土壤放线菌次生代谢产物生防活性的初步研究[D].湖南农业大学硕士学位论文,2005.
[17]郝永丽.拮抗放线菌的分离筛选与鉴定[D].西北农林科技大学硕士学位论文,2007.
[18]姜成林,徐丽华.微生物学论文集[C].北京:科学出版社,1985,53-57.
[19]何建清.藏东南地区土壤放线菌资源调查及应用研究[D].西北农林科技大学硕士学位论文,2006
[20]司美茹.青海高原(西部)土壤放线菌资源及应用研究[D].西北农林科技大学硕士学位论文,2003.
[21]熊亚南,杨润蕾,宋丽华,等.承德地区放线菌物种多样性分布的研究[J].河北农业大学学报, 2005,28(4):71-75
[22]苏涛,马宗琪,司美茹.鲁西南地区土壤放线菌的生态分布[J].山东农业科学, 2006,(2): 57-60.
[23]姜成林,徐丽华,杨宇容,等.云南若干地区放线菌区系及资源考查IX.滇西和滇东北地区[J].微生物学报, 1995,35(1):58-64.
[24]徐丽华,姜成林.云南若干地区放线菌区系及资源考查X.滇东南地区[J].微生物学报, 1996,36(1):48-52.
[25]姜成林.放线菌分类学进展[J].微生物学通报, 1996,23(1):51-55.
[26]胡承彪,苏俐英,梁秀堂.广西龙胜县里骆林区常绿阔叶林土壤微生物区系及生态特征研究[J].微生物杂志, 1996,6(3):12-17.
[27]张波,吴文君,宗兆锋.放线菌Z_(139)菌株的分离、鉴定及其生物活性[J].西北农林科技大学学报(自然科学版). 2005,33(08):69-72.
[28]杨秀芳,刘伟成,卢彩鸽,等.拮抗放线菌A03的生防作用及其分类鉴定[J].植物保护学报. 2007,34(01):73-77.
[29]谢晨昭,杨毅玲,李磊,等.拮抗放线菌B1菌株鉴定及其防治番茄灰霉病的初步研究[J].植物保护学报. 2008,35(04):102-109.
[30]刘燕娟,朱宏建,陈利娟,等.放线菌株HND39的种类鉴定及其对植物病原菌的抑制作用[J].中国生物防治. 2008,24(03):272-276.
[31]张清霞,陈洁,童蕴慧,等.棉花枯萎病拮抗放线菌K5的分离与鉴定[J].中国生物防治. 2008,24(04): 325-329.
[32]张桂兴,王树桐,方哲,等.香蕉镰刀菌枯萎病拮抗放线菌的筛选及菌株Da03047的鉴定[J].中国生物防治. 2007,23(S1):32-36.
[33]刘秋,齐小辉,闫建芳,等.瓜类枯萎病拮抗放线菌H628的鉴定[J].沈阳农业大学学报. 2008,39(02):178-181.
[34]孙强,闫建芳,刘秋,等.放线菌菌株MY02的鉴定及发酵液中抗真菌活性组分的分离[J].植物保护. 2007,33(05):71-74.
[35]姜云,黄丽丽,陈长卿,等.一株拮抗番茄叶霉病菌的放线菌筛选、鉴定及发酵条件研究[J].微生物学报. 2007,47(4):622-627.
[36]赵文婷,唐欣昀.抑制绿脓杆菌的放线菌株SM037的筛选、鉴定及发酵条件研究[J].生物学杂志. 2007,24(02):34-37.
[37]李勇,李文均,徐丽华,等.一株具抗菌活性放线菌菌株YIM31249T的分离和鉴定[J].云南大学学报(自然科学版). 2003,26(3):265-269.
[38]关统伟,王海孝,张利莉,等.喀什地区土壤放线菌区系及其拮抗植物病原真菌的研究[J].塔里木大学学报. 2006, 18(03):5-8.
[39]刘志鸿,程力,牟海津.海洋微生物活性物质的研究概况[J].中国水产科学.1999, 6(4):99-103.
[40]周世水,姚汝华.海洋微生物天然活性物质的开发应用进展[J].微生物学杂志.2002,22(2):42-44.
[41] Irel C M. Biomedieal Potential of Marine Natural Prod Uets. In:Marine Bioteehnology[J]. Plenum Press,NewYork and London,1993,1:l-4
[42] Seheur P J. Some Marine Eeologieal Phenomena[J]. Chemieal Basis and Biomedieal Potential Seienee,1990,248:1173-1176
[43] Jensen P R. Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectiviers[J]. Annurev Microbiol,1994,48:559-584
[44] Jensenp R D, Fenical W. Distribution of actinomycetes in near-shore tropical marine sediments[J]. Appl Environ Microbiol.1991,57:1102-1108.
[45]黄维真,方金瑞,苏国成.福建沿海底栖放线菌及其产生的抗菌物质.中国海洋药物,1991,39(3):1-6.
[46] Wang S J, Hu J C, Xue D L, et al. Studies on marine microorganism resource in Huanghai sea, Bohai sea and Liaoning regions of China[J] Jinzllou Nonnal Univ,2001,22(1):l-5.
[47]孟繁雯,叶亮,邢莹莹,等.海洋放线菌WBF16的分类鉴定[J].药物生物技术. 2008,15(02):124-128.
[48]张海涛,靳艳,吴佩春,等.一株海绵放线菌的分离鉴定及活性研究[J].微生物学通报. 2004,31(05):60-64.
[49]袁献温,杨瑞丽.一株具有抗肿瘤活性的海洋放线菌的分离和鉴定[J].微生物学通报. 2009,36(01):78-83.
[50]叶亮,程沁园,那广水,等.海洋放线菌WBF7的鉴定及其抗肿瘤代谢产物的初步研究[J].中国海洋药物. 2007,26(3):45-49.
[51]林亲雄,刘纯慧,奚涛,等.海洋放线菌M313菌株的鉴定及其抗肿瘤活性代谢产物的初步研究[J].海洋科学. 2006,30(11):53-57.
[52]杨臻峥,邢莹莹,奚涛.海洋放线菌M324抑菌活性代谢产物的研究初报[J].药物生物技术. 2008,15(05):375-379.
[53]杨文鸽,楼乔明,徐大伦,等.海洋放线菌XS904分类鉴定及其发酵液抑菌活性的研究[J].海洋与湖沼. 2008,39(05):369-374.
[54]赵心清,矫文策,袁文杰,等.大连地区海泥样品中分离的五株海洋放线菌的研究[J].氨基酸和生物资源. 2008,30(03):1-4.
[55]原居林,王高学,王建福,等.海洋放线菌FA-F-5对水产病原菌的抑制作用[J].西北农林科技大学学报(自然科学版). 2008,36(01):79-85.
[56]雷敬超,李传浩,黄惠琴,等.杀线虫海洋放线菌的筛选及菌株HA07011的鉴定[J].生物技术通报. 2007(06):146-149.
[57]方丽萍,龙建友,姬志勤.海洋放线菌I_(10)菌株发酵产物抗菌活性及其初步分类鉴定[J].西北农林科技大学学报(自然科学版). 2007,35(04):115-119.
[58]刘志恒.放线菌——微生物药物的重要资源[J].微生物学通报. 2005(06): 143-145.
[59] Maldonado L A , Fenical W, Jensen P R, et al. Salini-spora gen. nov., sp. nov., S.arenicola sp. nov., and S.tropica sp. nov., obligate marine actinomycetes belonging to the family micromonosporaceae[J]. Int J Syst Evol Microbiol, 2005, 55: 1759-1766.
[60]Oh D C, Williams P G, Kauffman C A, et al. Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"[J]. Org Lett, 2006, 8 (6): 1021-1024.
[61] Williams P G, Buchanan G O, Feling R H, et al. New cytotoxic salino sporamides from the marine actinomycete Salinispora tropica [J]. J Org Chem , 2005, 70 (16): 6196-6203.
[62] Robert H F, Greg O B, Tracy J M, et al. Salinosporamide a:a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora [J]. Angew Chem Int Ed, 2003,42 (3): 355-357.
[63]李丽琴,郑晓军,陈乐贵,等.蛋白酶体抑制剂药理活性的研究进展[J].国外医学药学分册, 2001,28 (3):132-136.
[64] Vincent P G, James M, Kin S L, et al. Drug discovery from natural products[J]. J Ind Microbiol Biotechnol, 2006,33(7): 523-531.
[65] Cho J Y, Kwon H C, Williams P G, et al.Actinofuranone A and B, new polyketides from a marinebacterium of the genus Streptomyces (Actinomycetes)[J]. J.Nat.Prod. 2006:69(3), 425-428.
[66] Riedlinger J, Reicke A, Zaehner H, et al. Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032[J]. J Antibiot, 2004,57(4):271-279.
[67] Bister B, Bischoff D, Stroebele M, et al. Abyssomicin C:A polycyclic antibiotic from a marine verrucosispora strain as an inhibitor of the p-Aminobenzoic acid/Tetrahydrofolate biosynthesis pathway[J]. Angew Chem Int EdEngl, 2004, 43(19):2574-2576.
[68] Paul R J , Tracy J M , Philip G W, et al. Marine actinomycete diversity and natural product discovery [J].Antonie van Leeuwenhoek, 2005, 87:43-48.
[69] Kwon H C, Kauffman C A, Jensen P R, et al. MarinomycinsA-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "Marinispora" [J]. J Am Chem Soc, 2006,128(5):1622-1632.
[70] Paul R J, Erin G, Chrisy M, et al. Culturable marine actinomycete diversity from tropical Pacific Ocean sediments [J]. Environ Microbiol, 2005,7(7):1039-1048.
[71] Ji Y C, Hak C K, Philip G W, et al. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)[J].Org Lett, 2006,8(12):2471-2474.
[72] Pathirana C, Paul R J, Fenical W. Marinone and debromomarinone: antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacterium[J].Tetrahedron Lett, 1992, 33(50):7663-7666.
[73] Ingo H, Paul R J , William F. Neomarinone and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales) [J]. Tetrahedron Lett, 2000, 41:2073-2076.
[74] Irma E S, Alejandra P, Paul R J, et al. Antibioticter penoid chloro-dihydroquinones from a new marine actinomycete [J]. J Nat Prod, 2005,68:904-910.
[75] Ji Y C, Hak C K, Philip G W, et al. ActinofuranonesA and B, polyketides from a marine-derived bacterium related to the genus Streptomyces(Actiomycetales)[J].J Nat Prod , 2006,69:425-428.
[76] James E M S, Luis A M , Alan C W, et al. Williamsia maris sp. nov., a novel actinomycete isolated from the sea of Japan [J]. Int J Syst Evol Microbiol, 2004,54:191-194.
[77] Joy A C, Joanne M, Michael G, et al. Novel rhodococci and other mycolate actinomycetes from the deep sea [J].Antonie van Leeuwenhoek, 1998,74:27-40.
[78] Lee S D. Blastococcus jejuensis sp.nov., an actinomycete from beach sediment and emended description of the genus Blastococcus Ahrens and Moll 1970[J]. Int J Syst Evol Microbiol, 2006,56 (10):2391-2396.
[79] Seo J P, Lee S D. Nocardia harenae sp. nov., an actinomycete isolated from beach sand[J]. Int J Syst Evol Microbiol, 2006, 56(9):2203-2207.
[80] Lee S D. Brevibacterium samyangense sp.nov., an actinomycete isolated from a beach sediment[J]. Int J Syst Evol M icrobiol, 2006, 56 (8):1889-1892.
[81] Pathom-aree W, Nogi Y, Sutcliffe I C, et al. Williamsiam arianensis sp. nov., a novel actinomycete isolated from the Mariana Trench[J]. Int J Syst Evol M icrobiol,2006,56(5): 1123-1126.
[82] Pathom-aree W, Nogi Y, Ward A C, et al. Dermacoccusbarathri sp. nov. and Derm acoccusprofundi sp. nov., novel actinomycetes isolated from deep sea mud of the Mariana Trench[J]. Int J Syst Evol Microbiol, 2006, 56(10):2303-2307.
[83] Hana Y, Peter S, Kyounghee S, et al. Serinicoccusm arinus gen. nov., a novel actinomycete withL-ornithine and L-serine in the peptidoglycan[J]. Int J Syst Evol Microbiol, 2004,54: 1585-1589.
[84] Lee S D. Kineococcus marinus sp. nov., isolated from marine sediment of the coast of Jeju, Korea [J]. Int J Syst Evol Microbiol, 2006,56(6): 1279-1283.
[85] Soraya A S, Nevine B G, Gehan A A, et al. Nocardiopsis aegyptia sp. nov., isolated from marine sediment[J]. Int J Syst Evol Microbiol, 2004, 54 (P t2):453-456.
[86]黄晓辉,李珊,谭周进,等.植物内生放线菌研究进展[J].生物技术通报.2008 (01).42-46.
[87]曹理想,周世宁.植物内生放线菌研究[J].微生物学通报. 2004,31(04):93-96.
[88]文才艺,吴元华,田秀玲.植物内生菌研究进展及其存在的问题[J].生态学杂志, 2004, 23(2):86-91.
[89] Shimizum, Nakagaway, Satoy,et al.Studies on endophytic actinomycetes (Ⅰ) :Streptomyces sp.isolated from rhododendron and its antifungal activity[J].Journal of General Plant Pathology,2000,66 (4):360-366.
[90]杨颖,陈华红,徐丽华.植物内生放线菌多样性研究[J].云南大学学报(自然科学版). 2008,30(S1):403-405.
[91] Benson D L, Silvester W B. Biology of Frankia strains actinomycete symbionts of actinorhizal plants[J].Mierobiol.Rev.1993,57:293-319.
[92]陈华红.傣药植物内生放线菌的多样性及多相分类研究[D].云南大学博士学位论文, 2007.
[93] Taeechowisan T,Peberdy J F,Lumyyong S.Isolation of endophytic actinomycetes from selected plants and their antifungal activity[J]. World J Microbiol Biotech, 2003, 19(4): 381-385.
[95] Coombs J T, Francoc M M. Isolation and identification of actinobacteria from surface sterilized wheat roots[J].Applied and Environmental Microbiology, 2003,69 (9) :5603 -5608.
[95]田新莉,曹理想,杨国武,等.水稻内生放线菌类群及其对宿主病原菌的抗性研究[J].微生物学报,2004,44(5):641-646.
[96] Sardi P, Saracehi M, Quaroni S, et al. Isolation of endophytie Streptomycea strains from surface sterilized roots[J].Appl Environ Mierobiol.1992,58:2691-2693.
[97] Amujo J M, Maeeheroni W, Aguilar C I , et al. Variability and interactions between endophytic bacteria and fungi isolated from leaf tissues of citrus rootstocks[J]. Can. J. Mierobiol, 2001, 47: 229- 236.
[98]陈华红,杨颖,姜怡,等.植物内生放线菌的分离方法[J].微生物学通报, 2006,33 (4):182-185.
[99]梁亚萍,宗兆锋,马强. 6株野生植物内生放线菌防病促生作用的初步研究[J].西北农林科技大学学报. 2007,35(07):131-136.
[100]李萌,张海涛,虞星炬,等.蔬菜内生菌的分离及其生防功能初探[J].江苏农业科学, 2003,(5):60-64.
[101]马强,宗兆锋,梁亚萍.凤县几种野生植物内生放线菌的分离筛选[J].西北农业学报. 2007,16(03):269-273.
[102] Castillo U F, Strobel G A, Ford E J, et al. Munumbicins, wide spectrum antibiotics produced by Streptomyces NRRL30562, endophytic on Kennedia nigricans[J]. Microbiology, 2002, 148: 2675-2685.
[103] Castillo U F, Strobel G A. Kakadumycuns, novel antibiotics from Streptomyces sp. NRRL30566, an endophyte of Grevillea pteridifolia[J]. FEMS Microbiology Letter, 2003,224:183-190.
[104] Pullen C, Schmitz P, Meurer K, et al. New and bioactive compound from Streptomyces strainsresiding in the wood of Celastraceae[J]. Planta, 2002, 216:162-167.
[105] Igarashi Y, Ogawa M, Sato Y, et al. Fistupyrone, a novel inhibitor of the infection of Chinese cabbage by Alternaria brassicioola, from Streptomyces sp.TP-A0569[J]. J Antibiotics, 2000,53: 1117-1122.
[106] Castillo U F,Browne L,Strobo G A,et al.Biologically active endophytic streptomycetes from Nothofagus spp.and other plants in Patagonia[J]. Mierob.Ecol. 2007,53:12-19.
[107]刘全永,胡江春,薛德林,等.海洋微生物生物活性物质研究[J].应用生态学报, 2002, 13(7) : 901-905.
[108]李文均,徐平,徐丽华,等.极端环境中的放线菌资源[J].微生物学报. 2003, 30(4): 125-126.
[109]姜成林,徐丽华,郭光远.云南若干地区土壤放线菌区系及资源考察V.高寒山区的放线菌[J].微生物学报, 1988,28(3): 198-200.
[110]杨宇容,徐丽华,李启任,等.低温环境中放线菌的研究[J].云南大学学报(自然科学版), 1997, 19(4): 397-402.
[111]姜成林等著.放线菌分类学[M].昆明:云南大学出版社.1995
[112] Schumann P, Prauser H, Rainey F A, et aL. Friedmanniella antarctica gen.nov., sp.nov., an LL-diaminopimelic acid-containing actinomycete from antarctics and stone[J]. Int J Syst Bacteriol. 1997,47:278-283.
[113] K?mpfer P, Rainey F A, Anderson M A, et aL. Frigoribacterium faenigen. nov, sp. nov., a novel psychrophilic genus of the family Microbacteriaceae[J]. Int J Syst Evol Microbiol. 2000,50:355-363.
[114] M?nnist M K, Schumann P, Rainey F A, et al. Subtercola boreus gen.nov., sp. nov., and Subtercola frigoraman sp. nov., two new psychrophilic actinobacteria isolated from boreal groundwater[J]. Int J Syst Evol Microbiol. 2000,50:1731-1739.
[115] Mevs U, Stackebrandt E, Schumann P, et al. Modestobacter multiseptatus gen. nov, a budding actinomycete from soils of the Asgard Range (Transantarctic Mountains)[J]. Int J Syst Evol Microbiol. 2000,50:337-346.
[116] Ruan J s, Tai A L, Zhou A M, et al. Actinopolyspora iragiensis sp., a new halophlic actinom-ycete islolated from soil[J]. Int J Syst Bacteriol, 1994,44:759-763.
[117] Tai A L, Rran J S. Nocardiopsis halophilasp nov, a new Halophilic Actiomycete isolated from soil[J]. Int J Syst Bacteriol, 1994,44:474-478.
[118] Cui X L, Mao P H, Tseng M, et al. Streptimonospora salina sp., a new member of the family Nocardiopsaceae[J]. Int J Syst Evol Microbiol, 2001,51:357-363.
[119]周培瑾,王大珍.亚嗜盐链霉菌新种的鉴定[J].微生物学报, 1983,23(3):216-219.
[120] Stackebrandt E, Koch C, Gvozdiak O, et al. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov, Nesterenkonia gen. nov, Kytococcus gen.nov, Dermacoccus gen. nov[J]. Int J Syst Evol Microbiol, 1995,45:682-692.
[121] Wang Y, Zhang Z S, Xu X L, et al. Actinopolymorpha singaporensis gen.nov, a novel actnomycete from the tropical rainforest of Singapore[J]. Int J Syst Evol Microbiol, 2001,51:467-473.
[122]张永光,李文均,张忠泽,等.碱性环境中的放线菌的生物学研究[J].微生物学通报, 2003, 30(1):73-77.
[123]张永光,唐蜀昆,李文均,等.嗜碱放线菌生理学特性的初步研究[J].微生物学通报, 2004, 31(1):30-35.
[124]沈玲,郭正彦,吴文君.极端环境中分离放线菌的方法[J].西北农业学报, 2005, 14(5):146-149.
[125]刘志恒,姜成林.放线菌现代生物学与生物技术[M].北京:科学出版社,2004.
[126] Meyer P S , KuPreaz J C, Kilian S G. Selection and evaluation of Astaxanth in Over-producing Mutans of Phaffia rhodoryma[J].World Journal of Microbiology and Biotechnology,1993,9:514-520.
[127] Hood K A, Zarembski D G. Mycophenolate mofetil: a uniqe immunosuppressive agent[J]. Am J Heath Systpharm,1997;54(3):285
[128] Adrio J L, Lopez M, Casqueiro J, Fernmdez C, et al. Electrophoretic karyo type of the as tax an thin-producing yeast Phaffia rhodozyma[J].Curr.Gener.1995,7:447-450.
[129]贾菊生,马德英.放线菌R1号菌株防治农作物病害的研究初报[J].新疆农业大学学报, 2001, 24(1):55-59.
[130]刘任,卢兆金.哈茨木霉T2菌株对辣椒土传真菌病害的控制作用[J].仲恺农业技术学院学报, 2003, 16 (l):6-11.
[131]邱思鑫,何红.内生芽抱杆菌TB2防治辣椒疫病效果及其机理初探[J].植物病理学报, 2004, 34(2):173-179.
[132]戴皖燕,关桂兰.两株对辣椒疫霉菌有拮抗作用的拮抗菌分泌蛋白的研究[J].中国生物防治, 2001,15(2):81-34.
[133]何美仙.寡雄腐霉和木霉对辣椒疫霉拮抗作用的初步研究[J].金华职业技术学院学报, 2002, 2:25-7.
[134]姚德明.新农用抗菌素的筛选[J].微生物学杂志, 1997,17(3):41- 43.
[135]方常福.抗病毒抗生素的筛选[J].微生物学杂志, 1996,16 (3):41- 46.
[136]郭予元.我国IPM研究进展回顾及对21世纪初发展目标的设想[J].植物保护, 1998, 24(1): 35- 38.
[137]范玲.微生物农药研究进展及产业发展对策[J].中国生物工程杂志, 2002,22(5):83-86.
[138]林壁润,谢双大,杨丽梅,等.抗生素2507对蔬菜卵菌病害的防治作用及稳定性研究[J].植物保护, 2000,26(2):11-13.
[139]吴军林,林炜铁,彭云平,等.防治植物病害的农用抗生素研究及应用[J].新农药, 2003,30(4):27-33
[140]王爱民,李晓刚,林壁润.杀虫抗生素的研究进展[J].广东农业科学, 2008,(8):76-78.
[141]沈寅初.农用抗生素研究开发的新进展[J].国外医药抗生素分册,1998,19(3):155- 160.
[142] Takahaskia, Kurasawas, Ikedad, et al. Altemicidin, a new acaricidal and antitumor substance [J]. Jantibot,1989,42:1556- 1561.
[143]王润华,涂国全,高勇生.梅岭霉素生物学特性及其产生菌特性的研究[J].江西农业大学学报, 1995,17(4):455- 461.
[144]陈华保.土壤放线菌农用活性菌株的筛选及研究[D].西北农林科技大学硕士学位论文, 2005.
[145]李洹,汪清民,黄润秋.多杀菌素的研究进展[J].农药学学报, 2003,5(2):1- 12.
[146]聂奎,曾中良,余鹏南,等.阿维菌素族抗寄生虫药物的研究[J].四川畜牧兽医学院学报, 2000, 14(4):42- 47.
[147]许建平,李德葆,吕忠平.新型抗生素类杀虫药物阿弗米丁研究与应用概况[J].浙江农业科学, 1996(3):136-137.
[148]许再福.生物药物素AVERMECTINS及其在农业害虫防治中的应用[J].微生物学通报, 1995, 22(2):112- 115.
[149]余凤玉,李振华,曾会才.抗真菌农用抗生素的研究进展[J].热带农业科学, 2005,25(1):60-65.
[150]商瑞,曾会才,毛佳.农用抗生素分离纯化的研究进展[J].广东农业科学, 2008, (2):124-126.
[151]安德荣,穆小倩.瑞拉菌素产生菌的鉴定[J].微生物学杂志, 2002,22(2):5-6.
[152]施跃锋,桑金隆,竺利红,等.新微生物农药抑霉菌素的研究[J].核农学报, 2004, 18(1):68-71.
[153]林壁润,谢双大,杨丽梅,等.抗生素2507对蔬菜卵菌病害的防治作用及稳定性研究[J].植物保护, 2000, 26(2):11-13.
[154]林壁润,谢双大,江学斌,等.抗生素2507对黄瓜疫病菌的抗生作用[J].植物保护学报, 2001, 28(2):113-117.
[155]郭永霞,孔祥清.天然除草活性化合物研究进展[J].植物保护, 2005, 31(6):11-16.
[156]彭浩,贺红武.从天然产物源寻找新的除草机制[J] .世界农药,2002 ,24(3) :1-5.
[157]余柳青,黄世文,等.微生物除草剂的研究和开发进展[A] .喻子牛主编.微生物农药及其产业化[C] .北京:科学出版社,2000,256-259.
[158]徐文平,陶黎明.生物除草剂9018的研究[J].上海化工, 2000,24(15):21-22.
[159]龙建友,姬志勤.西农No.24菌株发酵产物对反枝苋的除草活性初步研究[J].农药学学报, 2004, 6(1):89-92.
[160]龙建友,钱勇.一株放线菌代谢产物除草活性的初步研究[J].微生物学杂志, 2006, 26(1): 106-108.
[161]李韶菁,杜冠华.由一株放线菌产生的对谷胱苷肽转移酶具有抑制作用的活性化合物的研究[J].中国抗生素杂志. 2007, 32(7).
[162]刘睿,方玉春,段琳,等.海绵共附生放线菌Saccharopolyspora sp.nov中抗肿瘤活性成分的研究[J].中国抗生素杂志. 2006, 31(11): 646-649.
[163]徐文平,袁生,陶黎明,等.放线菌10885除草活性物质的分离鉴定[J].农药. 2007(12).
[164]沈显斌,赵雪平,王子洪.放线菌JXJ-35次生代谢产物的初步研究[J].九江学院学报. 2007, (06):69-71.
[165] Ben A M, Sioud S, Fourati B F, et al. Purification and structure determination of four bioactive molecules from a newly isolated Streptomyces sp. TN97 strain[J]. Process Biochemistry. 2006,41(7):1506-1513.
[166]刘宁,张辉,郑文,等.药用植物内生放线菌的生物活性及菌株D62的代谢产物分析[J].微生物学报. 2007,47(5).
[167] Attila K, Zsuzsanna S, IldikóL, et al. Production of FK520 by Streptomyces tubercidicus[J]. Microbiological Research. 2008, 163(6):624-632.
[168] Fourati-ben F L, Fotso S, Ben A M, et al. Purification and structure elucidation of antifungal and antibacterial activities of newly isolated Streptomyces sp. strain US80[J]. Research in Microbiology. 2005, 156(3): 341-347.
[169] Mukhopadhyay T, Nadkarni S R, Patel M V, et al. Maclafungin, a new antifungal macrocyclic lactone from Actinomycete sp.Y-8521050[J]. Tetrahedron. 1998,54(44): 13621-13628.
[170]陈光英,朱峰,林永成.海洋放线菌Streptomyces sp.V5产生的一个新的八元环内酯[J].有机化学. 2007, 27(9): 1159-1161.
[171]赵文英,顾谦群,朱伟明.海绵共附生放线菌SH6004菌株中抗肿瘤活性成分的研究[J].中国海洋大学学报(自然科学版). 2008,38(01):23-26.
[172]李德海,顾谦群,朱伟明,等.海洋放线菌11014中抗肿瘤活性成分的研究I.环二肽[J].中国抗生素杂志. 2005,30(8): 449-452.
[173]黄麟,张庆林,肖凤君,等.土壤放线菌3423代谢产物的分离纯化及结构鉴定[J].中国抗生素杂志. 2007, 32(5):320-322.
[174] Xi F L, Kim Y H, Jung J H, et al. Microbial transformation of the bioactive sesquiterpene, cyclonerodiol, by the ascomycete Penicillium sp. and the actinomycete Streptomyces sp.[J]. Enzyme and Microbial Technology. 2007,40(5): 1188-1192.
[175] Komatsu K, Tsuda M, Shiro M, et al. Brasilicardins B-D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis[J]. Bioorganic & Medicinal Chemistry. 2004, 12(21): 5545-5551.
[176]吴少杰,李富超,秦松,等.海洋链霉菌M518产的新星形孢菌素衍生物的生物活性[J].高技术通讯. 2007,17(8):874-879.
[177]刘睿,朱天骄,朱伟明,等.海洋放线菌S1001中抗肿瘤活性成分的研究[J].中国抗生素杂志. 2006, 31(1):36-38.
[178]孙军利,王金来,王丽云,等.放线菌SPRI10304次级代谢产物中杀菌活性物质的分离提取及结构鉴定[J].化学与生物工程. 2008,25(01):43-47
[179]姬志勤,魏少鹏,杨春平,等.秦岭链霉菌发酵液中二丙酮胺的分离及抑菌活性初步研究[J].西北农林科技大学学报(自然科学版). 2008,36(02):148-152.
[180] Igarashi Y, Trujillo M E, Mart M E, et al. Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.[J]. Bioorganic & Medicinal Chemistry Letters. 2007, 17(13): 3702-3705.
[181] Hang Y B, Lee M Y, Park H J, et al. Isolation of putative polyene-producing actinomycetes strains via PCR-based genome screening for polyene-specific hydroxylase genes[J]. Process Biochemistry. 2007, 42(1):102-107.
[182] Hopmann C, Kurz M, Br M, et al. Isolation and structure elucidation of vancoresmycin--a new antibiotic from Amycolatopsis sp. ST101170[J]. Tetrahedron Letters. 2002,43(3): 435-438.
[183] Schumacher R W, Harrigan B L, Davidson B S. KahakamidesA and B, new neosidomycin metabolites from a marine-derived actinomycete[J]. Tetrahedron Letters. 2001,42(31): 5133-5135.
[184] Ohta E, Ohta S, Kubota N K, et al. Micromonospolide A, a new macrolide from Micromonospora sp.[J]. Tetrahedron Letters. 2001,42(25):4179-4181.
[185] Hardt I H, Jensen P R, Fenical W. Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales)[J]. Tetrahedron Letters. 2000, 41 (13): 2073- 2076.
[186]Williams D E, Bernan V S, Ritacco F V, et al. HolyrinesA and B, possible intermediates in staurosporine biosynthesis produced in culture by a marine actinomycete obtained from the North Atlantic Ocean[J]. Tetrahedron Letters. 1999,40(40):7171-7174.
[187] Pettit G R, Tan R, Melody N, et al. Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete[J]. Bioorganic & Medicinal Chemistry. 1999,7(5): 895-899.
[188] Stadler M, Henkel T, M H, et al. Identification of alkaloids and polyketides in an Actinomycete by high-performance liquid chromatography with mass spectrometric and UV-Visible detection[J]. Journal of Chromatography A. 1998,818(2):187-195.
[189]李津成.在三江源区生态保护与可持续发展高级研讨会开幕式上的讲话.青海科技,2005(4): 4-7.
[190]刘欢,安德荣,慕小倩,等.土壤中抗真菌放线菌L H33发酵提取物活性研究[J].西北农林科技大学学报(自然科学版), 2009,31(1):145-150
[191]方羽生,杨卫华,张洪玲,等.放线菌对4种病原真菌的拮抗作用初探[J].广东农业科学. 2001(05):39-41.
[192]李小俊,成丽霞,吴彦彬,等.拮抗菌抗菌谱及发酵液拮抗能力测定的新方法[J].生物技术. 2007, 17(1):56-58.
[193]方中达.植病研究方法(第三版)[M].北京:中国农业出版社, 1998.
[194]慕立义.植物化学保护研究方法[M].北京:中国农业出版社, 1994.
[195]陈定花,朱卫刚,吴永刚.黄瓜灰霉病子叶筛选法初探研究[J].浙江化工,2000(S1):38-39.
[196]李树正,张素华.杀菌剂筛选方法的研究[J].农药, 1997, 36(9): 20-22.
[197]吴文君.植物化学保护实验技术导论[M].西安:陕西科技出版社, 1987: 141-145.
[198]农业部农药检定所生测室.农药田间药效试验准则(一)[M].北京:中国标准出版社,1993,10.
[199]张兴,王兴林.植物化学保护实验指导[M ].杨凌:西北农林科技大学出版社,2000,66-68.
[200]刘霞.昆虫病原线虫共生菌YL001菌株的代谢产物及其抑菌活性研究[D].西北农林科技大学博士学位论文,2006.
[201]乔宏萍.小麦内生细菌对小麦全蚀病的生物防治研究[D].西北农林科技大学博士学位论文,2006.
[202]宋虎.小麦全蚀病的生物防治研究及品种抗性鉴定[D].河南农业大学硕士学位论文,2004.
[203]李乐.放线菌株YB024对小麦全蚀病生物防治机制研究[D].河南农业大学硕士学位论文,2006.
[204]王小鹏. 20﹪福·邻悬浮种衣剂防治小麦纹枯病和全蚀病初步研究[D].中国农业大学硕士学位论文,2007.
[205] Michael T M, Aharon O. Thermophilic and halophilic extremophiles[J]. Current Opinion in Microbiology, 1999,2:265-269.
[206]李子东,藏立华.极端微生物:一种新型的酶资源[J].微生物学报,2004,5:89-92.
[207]钱存柔,董碧红.微生物学基础知识和实验指导[M].北京:科学出版社, 1979.
[208]程丽娟,薛泉宏.微生物学实验指导[M].西安:兴国图书出版社,2000.
[209]刘会强,张立丰,韩彬,等.嗜盐菌的研究新进展[J].新疆师范大学学报(自然科学版), 2005,24(3):84-88.
[210]阎旭光,吴剑波. 16SrRNA在放线菌分子鉴别和分类中的作用及RFLP和RAPD的应用[J].国外医药抗生素分册, 1997,18(6):409-417.
[211]张妍,张建丽,牛宁昌.放线菌的分子分类[J].微生物学杂志, 2007, 27(4):79-82.
[212]马邦亚,杨俊秀,曹支敏.放线菌分类的历史和研究现状[J].西北林学院学报,1999, 14 (3) : 76-80.
[213]王意敏,刘志恒.放线菌的多相分类[J].微生物学通报, 1999,26(2):137-140.
[214]张燕新,吴莹,张迹,等.高温放线菌分类的研究进展[J].微生物学杂志, 2007, 27(1):64-69.
[215]张建丽,刘志恒.诺卡氏菌型放线菌的分类[J].微生物学报, 2001,41(4):515-517.
[216]李文均,张忠泽,姜成林.高温放线菌属分类研究进展[J].微生物学报, 2002, 42(6): 759-763.
[217]张纪忠,黄静娟.微生物分类学[M].上海:复旦大学出版社, 1990.
[218]康振生.植物病原真菌的超微结构[M].北京:中国科学技术出版社,1996.
[219]中国科学院微生物研究所放线菌分类组编著.链霉菌鉴定手册[M].北京:科学出版社,1975.
[220]徐平,李文均,徐丽华.微波法快速提取放线菌基因组DNA[J].微生物学通报. 2003, 30(4): 82-85.
[221]姜淑梅,张龙,戴世鲲,等.一种简单、有效的适于PCR操作的放线菌DNA提取方法[J].生物技术. 2007, (01):39-41.
[222]黄培堂等译.分子克隆实验指南(第三版)[M].北京:科学出版社,2002.
[223]阎逊初.放线菌的分类和鉴定[M].北京:科学出版社,1992.
[224]周煜. 16S rRNA序列分析法在医学微生物鉴定中的应用[J].生物技术通讯. 1999(04): 297-305.
[225]张晓君,冯清平,白玲.分子生态学方法在微生物多样性研究中的应用[J].微生物学通报. 1999,29(01):68-70.
[226]徐丽华,李文均,张玉琴,等.关于细菌新分类单元描述的标准化[J].微生物学通报, 2004, 31(6):126-127.
[227] Palmqvist, Eva, Hahn H, et al. Fermentaion of lignocellulosic hydrolysatesⅡ: inhibitors and mechanisms of inhibition[J]. Bioresource Technology, 2000,74(1):25-33.
[228] Kiers J L, Vanlaeken A E A, Rombouts F M, et al. vitro digestibility of Bacillus fermented soya bean [J].International Journal of Food Microbiology, 2000,60(3):163-169.
[229]王永宏,张兴. Xenorhabdus nematophila YL001培养基筛选和培养条件优化[J].生物加工过程, 2006,4(2):58-63.
[230] Han Y, Li Z, Miao X, et al. Statistical optimization of medium components to improve the chitinase activity of Streptomyces sp. Da11 associated with the South China Sea sponge Craniella australiensis[J]. Process Biochemistry Metabolic Engineering. 2008, 43(10): 1088-1093.
[231] Purama R K, Goyal A. Screening and optimization of nutritional factors for higher dextransucrase production by Leuconostoc mesenteroides NRRL B-640 using statistical approach[J]. Bioresource Technology. 2008, 99(15): 7108-7114.
[232] Khosravi D K, Zoghi A. Comparison of pretreatment strategies of sugarcane baggase: Experimental design for citric acid production[J]. Bioresource Technology. 2008, 99(15): 6986-6993.
[233] Talpur F N, Bhanger M I, Rahman A U, et al. Application of factorial design in optimization of anion exchange resin based methylation of vegetable oil and fats[J]. Innovative Food Science & Emerging Technologies. 2008, 9(4): 608-613.
[234] Li X Y, Liu Z Q, Chi Z M. Production of phytase by a marine yeast Kodamaea ohmeri BG3 in an oats medium: Optimization by response surface methodology[J]. Bioresource Technology. 2008, 99(14): 6386-6390.
[235] Imandi S B, Bandaru V V, Somalanka S R, et al. Application of statistical experimental designs for the optimization of medium constituents for the production of citric acid from pineapple waste[J]. Bioresource Technology. 2008, 99(10): 4445-4450.
[236]褚以文.微生物培养基优化方法及其OPTI优化软件[J].国外医药抗生素分册, 1999, 20(2): 58-60, 66.
[237]张字镭,党璇,贺平安.利用Pearson相关系数定量分析生物亲缘关系[J].计算机工程与应用, 2005, 33:79-83.
[238]高修功,王超,章克昌.数学统计法快速优化假单胞菌脂肪酶发酵条件[J].微生物学通报, 1998, 25(2):94-97
[239] Weuster D. Experimental design for fermentation media development: statistical design or global random search [J]. J Bioscience and Bioengineering, 2000, 90 (5): 473-483.
[240] Ambat P, Ayyanna C. Optimizing medium constituents and fermentation conditions for citric acid production from palmyra jaggery using response surface methods[J]. Journal of Microbiology &Biotechnology, 2001,17:331-335.
[241] Ratnam B V V, Narasimha Rao M. Dmodar Rao M, et a1. Optimization of fermentation conditions for the production of ethanol from sago starch using response surface methodology[J]. Journal of Microbiology & Biotechnology, 2003,19:523-526.
[242] Trupkin S , Levin S , Forchiassin F. Optimization of a culture medium for ligninolytic enzyme production and synthetic dye decolorization using response surface methodology[J]. Journal of Industrial Microbiology Biotechnology, 2003,30:682-690.
[243]朱昌雄.农用抗生素——中生菌素[J].精细与专用化学品, 2002,(16):14-17.
[244] Nobili M De, Contin M, Mondini C, et al.Soil microbial biomass is triggered into activity by trace amounts of substrate[J].Soil Biology and biochemistry.2001,33:1163-1170
[245]陈毓荃.生物化学实验方法和技术[M].北京:科学出版社,2002.
[247] Fernando P. The historical delivery of antibiotics from microbial natural products-Can history repeat [J]. Biochem Pharmacol, 2006,71:9 81-990
[248]王俊儒.天然产物提取分离与鉴定技术[M].西北农林科技大学,2003.
[249]周德庆.微生物实验手册[M].上海:上海科学技术出版社,1986.
[250]常建华,董绮功.波谱原理及解析[M].科学出版社,2001.
[251]宁永成.有机化合物结构鉴定与有机波谱学[M].科学出版社,2000.
[252]赵瑶兴,孙祥玉编.有机分子结构光谱鉴定[M].科学出版社,2002.
[253] Robert M S, Francis X W, David J K.有机化合物的波普解析[M].华东理工大学出版社,2007.
[254] Swarna A G, Gordon W R, Bruce C B, et al. Phenazine-1-carboxamides: Structure–cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain[J]. Bioorganic & Medicinal Chemistry, 2006, 14(4):1160–1168.
[255]谢一辉,邓鹏,张叶青.安痛藤化学成分研究[J].中草药, 2009,32(2):210-213.
[256]赵晓亚,孙汉董,吴继洲.冷水七根茎的化学成分研究[J].中国中药杂志, 2005, 30(8): 584-586.
[257]辛菲,金艺淑,沙沂.马鞭草化学成分研究[J].中国现代中药,2008,10(10):21-23.
[258]李厚金,林永成,刘晓红.红树林内源真菌2524号的肽类成分(Ⅰ).中山大学学报(自然科学版), 2002,41(1):110-112.
[2]陈建辉,叶正,梁小慧.八五期间我国生物防治技术研究进展[M].中国植物保护研究进展,1996,40-43.
[3]赵继红,李建中.微生物农药杀菌剂研究进展[J].农药,2003,42(5):6-8.
[4]张兴,马志卿,李广泽,等.生物农药评述[J].西北农林科技大学学报, 2002,30 (2):142- 148.
[5]纪明山,谷祖敏,张杨.生物农药研究与应用现状及发展前景[J].沈阳农业大学学报,2006,08,37(4):54-55.
[6]李树正,张素华.杀菌剂筛选方法的研究[J].农药, 1997,36(9):20-22.
[7]李勇等.微生物农药的研究和应用进展[J].贵州农业科学, 2003,31(2):64-66.
[8] Shimizu M, Nakagawa Y, Sato Y, et al. Studies on endophytic actinomycetes ( I ) Streptomyces sp. isolated from rhododendron and its antifungal activity[J]. Journal of General Plant Pathology, 2000,66(4): 360-366.
[9] Nishimura T, Meguro A, Hasegawa S, et al. An endophytic actinomycete, streptomyces sp. AOK-30, isolated from mountain laurel and its antifungal activity[J]. Journal of General Plant Pathology, 2002,68(4): 390-397.
[10]黄世文,高成伟,王玲,等.土壤中有益放线菌的高效分离、筛选和生物测定技术[J].植物保护, 2008,34(1):138-141.
[11]李新,纪明山.土壤中拮抗放线菌的分离和筛选[J].河南农业科学.2008,(1):58-60.
[12]安德荣,穆小倩,刘翠娟,等.土壤拮抗放线菌的分离和筛选[J].微生物学杂志, 2002,22(5):1-3.
[13]周鑫钰,朱宏建,易图永.土壤放线菌生防活性物质的研究进展[J].作物研究, 2007, 21(2):149-151.
[14]刘红艳,张亚莲,包小村,等.茶园土壤拮抗放线菌的分离和筛选[J].湖南农业大学学报(自然科学版),2008(06):701-703.
[15]张炳火,方亮,李汉全,等.微生物资源研究开发进展[J].国外医药:抗生素分册. 2006, 27(5): 233-235.
[16]朱红建.土壤放线菌次生代谢产物生防活性的初步研究[D].湖南农业大学硕士学位论文,2005.
[17]郝永丽.拮抗放线菌的分离筛选与鉴定[D].西北农林科技大学硕士学位论文,2007.
[18]姜成林,徐丽华.微生物学论文集[C].北京:科学出版社,1985,53-57.
[19]何建清.藏东南地区土壤放线菌资源调查及应用研究[D].西北农林科技大学硕士学位论文,2006
[20]司美茹.青海高原(西部)土壤放线菌资源及应用研究[D].西北农林科技大学硕士学位论文,2003.
[21]熊亚南,杨润蕾,宋丽华,等.承德地区放线菌物种多样性分布的研究[J].河北农业大学学报, 2005,28(4):71-75
[22]苏涛,马宗琪,司美茹.鲁西南地区土壤放线菌的生态分布[J].山东农业科学, 2006,(2): 57-60.
[23]姜成林,徐丽华,杨宇容,等.云南若干地区放线菌区系及资源考查IX.滇西和滇东北地区[J].微生物学报, 1995,35(1):58-64.
[24]徐丽华,姜成林.云南若干地区放线菌区系及资源考查X.滇东南地区[J].微生物学报, 1996,36(1):48-52.
[25]姜成林.放线菌分类学进展[J].微生物学通报, 1996,23(1):51-55.
[26]胡承彪,苏俐英,梁秀堂.广西龙胜县里骆林区常绿阔叶林土壤微生物区系及生态特征研究[J].微生物杂志, 1996,6(3):12-17.
[27]张波,吴文君,宗兆锋.放线菌Z_(139)菌株的分离、鉴定及其生物活性[J].西北农林科技大学学报(自然科学版). 2005,33(08):69-72.
[28]杨秀芳,刘伟成,卢彩鸽,等.拮抗放线菌A03的生防作用及其分类鉴定[J].植物保护学报. 2007,34(01):73-77.
[29]谢晨昭,杨毅玲,李磊,等.拮抗放线菌B1菌株鉴定及其防治番茄灰霉病的初步研究[J].植物保护学报. 2008,35(04):102-109.
[30]刘燕娟,朱宏建,陈利娟,等.放线菌株HND39的种类鉴定及其对植物病原菌的抑制作用[J].中国生物防治. 2008,24(03):272-276.
[31]张清霞,陈洁,童蕴慧,等.棉花枯萎病拮抗放线菌K5的分离与鉴定[J].中国生物防治. 2008,24(04): 325-329.
[32]张桂兴,王树桐,方哲,等.香蕉镰刀菌枯萎病拮抗放线菌的筛选及菌株Da03047的鉴定[J].中国生物防治. 2007,23(S1):32-36.
[33]刘秋,齐小辉,闫建芳,等.瓜类枯萎病拮抗放线菌H628的鉴定[J].沈阳农业大学学报. 2008,39(02):178-181.
[34]孙强,闫建芳,刘秋,等.放线菌菌株MY02的鉴定及发酵液中抗真菌活性组分的分离[J].植物保护. 2007,33(05):71-74.
[35]姜云,黄丽丽,陈长卿,等.一株拮抗番茄叶霉病菌的放线菌筛选、鉴定及发酵条件研究[J].微生物学报. 2007,47(4):622-627.
[36]赵文婷,唐欣昀.抑制绿脓杆菌的放线菌株SM037的筛选、鉴定及发酵条件研究[J].生物学杂志. 2007,24(02):34-37.
[37]李勇,李文均,徐丽华,等.一株具抗菌活性放线菌菌株YIM31249T的分离和鉴定[J].云南大学学报(自然科学版). 2003,26(3):265-269.
[38]关统伟,王海孝,张利莉,等.喀什地区土壤放线菌区系及其拮抗植物病原真菌的研究[J].塔里木大学学报. 2006, 18(03):5-8.
[39]刘志鸿,程力,牟海津.海洋微生物活性物质的研究概况[J].中国水产科学.1999, 6(4):99-103.
[40]周世水,姚汝华.海洋微生物天然活性物质的开发应用进展[J].微生物学杂志.2002,22(2):42-44.
[41] Irel C M. Biomedieal Potential of Marine Natural Prod Uets. In:Marine Bioteehnology[J]. Plenum Press,NewYork and London,1993,1:l-4
[42] Seheur P J. Some Marine Eeologieal Phenomena[J]. Chemieal Basis and Biomedieal Potential Seienee,1990,248:1173-1176
[43] Jensen P R. Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectiviers[J]. Annurev Microbiol,1994,48:559-584
[44] Jensenp R D, Fenical W. Distribution of actinomycetes in near-shore tropical marine sediments[J]. Appl Environ Microbiol.1991,57:1102-1108.
[45]黄维真,方金瑞,苏国成.福建沿海底栖放线菌及其产生的抗菌物质.中国海洋药物,1991,39(3):1-6.
[46] Wang S J, Hu J C, Xue D L, et al. Studies on marine microorganism resource in Huanghai sea, Bohai sea and Liaoning regions of China[J] Jinzllou Nonnal Univ,2001,22(1):l-5.
[47]孟繁雯,叶亮,邢莹莹,等.海洋放线菌WBF16的分类鉴定[J].药物生物技术. 2008,15(02):124-128.
[48]张海涛,靳艳,吴佩春,等.一株海绵放线菌的分离鉴定及活性研究[J].微生物学通报. 2004,31(05):60-64.
[49]袁献温,杨瑞丽.一株具有抗肿瘤活性的海洋放线菌的分离和鉴定[J].微生物学通报. 2009,36(01):78-83.
[50]叶亮,程沁园,那广水,等.海洋放线菌WBF7的鉴定及其抗肿瘤代谢产物的初步研究[J].中国海洋药物. 2007,26(3):45-49.
[51]林亲雄,刘纯慧,奚涛,等.海洋放线菌M313菌株的鉴定及其抗肿瘤活性代谢产物的初步研究[J].海洋科学. 2006,30(11):53-57.
[52]杨臻峥,邢莹莹,奚涛.海洋放线菌M324抑菌活性代谢产物的研究初报[J].药物生物技术. 2008,15(05):375-379.
[53]杨文鸽,楼乔明,徐大伦,等.海洋放线菌XS904分类鉴定及其发酵液抑菌活性的研究[J].海洋与湖沼. 2008,39(05):369-374.
[54]赵心清,矫文策,袁文杰,等.大连地区海泥样品中分离的五株海洋放线菌的研究[J].氨基酸和生物资源. 2008,30(03):1-4.
[55]原居林,王高学,王建福,等.海洋放线菌FA-F-5对水产病原菌的抑制作用[J].西北农林科技大学学报(自然科学版). 2008,36(01):79-85.
[56]雷敬超,李传浩,黄惠琴,等.杀线虫海洋放线菌的筛选及菌株HA07011的鉴定[J].生物技术通报. 2007(06):146-149.
[57]方丽萍,龙建友,姬志勤.海洋放线菌I_(10)菌株发酵产物抗菌活性及其初步分类鉴定[J].西北农林科技大学学报(自然科学版). 2007,35(04):115-119.
[58]刘志恒.放线菌——微生物药物的重要资源[J].微生物学通报. 2005(06): 143-145.
[59] Maldonado L A , Fenical W, Jensen P R, et al. Salini-spora gen. nov., sp. nov., S.arenicola sp. nov., and S.tropica sp. nov., obligate marine actinomycetes belonging to the family micromonosporaceae[J]. Int J Syst Evol Microbiol, 2005, 55: 1759-1766.
[60]Oh D C, Williams P G, Kauffman C A, et al. Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"[J]. Org Lett, 2006, 8 (6): 1021-1024.
[61] Williams P G, Buchanan G O, Feling R H, et al. New cytotoxic salino sporamides from the marine actinomycete Salinispora tropica [J]. J Org Chem , 2005, 70 (16): 6196-6203.
[62] Robert H F, Greg O B, Tracy J M, et al. Salinosporamide a:a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora [J]. Angew Chem Int Ed, 2003,42 (3): 355-357.
[63]李丽琴,郑晓军,陈乐贵,等.蛋白酶体抑制剂药理活性的研究进展[J].国外医学药学分册, 2001,28 (3):132-136.
[64] Vincent P G, James M, Kin S L, et al. Drug discovery from natural products[J]. J Ind Microbiol Biotechnol, 2006,33(7): 523-531.
[65] Cho J Y, Kwon H C, Williams P G, et al.Actinofuranone A and B, new polyketides from a marinebacterium of the genus Streptomyces (Actinomycetes)[J]. J.Nat.Prod. 2006:69(3), 425-428.
[66] Riedlinger J, Reicke A, Zaehner H, et al. Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032[J]. J Antibiot, 2004,57(4):271-279.
[67] Bister B, Bischoff D, Stroebele M, et al. Abyssomicin C:A polycyclic antibiotic from a marine verrucosispora strain as an inhibitor of the p-Aminobenzoic acid/Tetrahydrofolate biosynthesis pathway[J]. Angew Chem Int EdEngl, 2004, 43(19):2574-2576.
[68] Paul R J , Tracy J M , Philip G W, et al. Marine actinomycete diversity and natural product discovery [J].Antonie van Leeuwenhoek, 2005, 87:43-48.
[69] Kwon H C, Kauffman C A, Jensen P R, et al. MarinomycinsA-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "Marinispora" [J]. J Am Chem Soc, 2006,128(5):1622-1632.
[70] Paul R J, Erin G, Chrisy M, et al. Culturable marine actinomycete diversity from tropical Pacific Ocean sediments [J]. Environ Microbiol, 2005,7(7):1039-1048.
[71] Ji Y C, Hak C K, Philip G W, et al. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)[J].Org Lett, 2006,8(12):2471-2474.
[72] Pathirana C, Paul R J, Fenical W. Marinone and debromomarinone: antibiotic sesquiterpenoid naphthoquinones of a new structure class from a marine bacterium[J].Tetrahedron Lett, 1992, 33(50):7663-7666.
[73] Ingo H, Paul R J , William F. Neomarinone and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales) [J]. Tetrahedron Lett, 2000, 41:2073-2076.
[74] Irma E S, Alejandra P, Paul R J, et al. Antibioticter penoid chloro-dihydroquinones from a new marine actinomycete [J]. J Nat Prod, 2005,68:904-910.
[75] Ji Y C, Hak C K, Philip G W, et al. ActinofuranonesA and B, polyketides from a marine-derived bacterium related to the genus Streptomyces(Actiomycetales)[J].J Nat Prod , 2006,69:425-428.
[76] James E M S, Luis A M , Alan C W, et al. Williamsia maris sp. nov., a novel actinomycete isolated from the sea of Japan [J]. Int J Syst Evol Microbiol, 2004,54:191-194.
[77] Joy A C, Joanne M, Michael G, et al. Novel rhodococci and other mycolate actinomycetes from the deep sea [J].Antonie van Leeuwenhoek, 1998,74:27-40.
[78] Lee S D. Blastococcus jejuensis sp.nov., an actinomycete from beach sediment and emended description of the genus Blastococcus Ahrens and Moll 1970[J]. Int J Syst Evol Microbiol, 2006,56 (10):2391-2396.
[79] Seo J P, Lee S D. Nocardia harenae sp. nov., an actinomycete isolated from beach sand[J]. Int J Syst Evol Microbiol, 2006, 56(9):2203-2207.
[80] Lee S D. Brevibacterium samyangense sp.nov., an actinomycete isolated from a beach sediment[J]. Int J Syst Evol M icrobiol, 2006, 56 (8):1889-1892.
[81] Pathom-aree W, Nogi Y, Sutcliffe I C, et al. Williamsiam arianensis sp. nov., a novel actinomycete isolated from the Mariana Trench[J]. Int J Syst Evol M icrobiol,2006,56(5): 1123-1126.
[82] Pathom-aree W, Nogi Y, Ward A C, et al. Dermacoccusbarathri sp. nov. and Derm acoccusprofundi sp. nov., novel actinomycetes isolated from deep sea mud of the Mariana Trench[J]. Int J Syst Evol Microbiol, 2006, 56(10):2303-2307.
[83] Hana Y, Peter S, Kyounghee S, et al. Serinicoccusm arinus gen. nov., a novel actinomycete withL-ornithine and L-serine in the peptidoglycan[J]. Int J Syst Evol Microbiol, 2004,54: 1585-1589.
[84] Lee S D. Kineococcus marinus sp. nov., isolated from marine sediment of the coast of Jeju, Korea [J]. Int J Syst Evol Microbiol, 2006,56(6): 1279-1283.
[85] Soraya A S, Nevine B G, Gehan A A, et al. Nocardiopsis aegyptia sp. nov., isolated from marine sediment[J]. Int J Syst Evol Microbiol, 2004, 54 (P t2):453-456.
[86]黄晓辉,李珊,谭周进,等.植物内生放线菌研究进展[J].生物技术通报.2008 (01).42-46.
[87]曹理想,周世宁.植物内生放线菌研究[J].微生物学通报. 2004,31(04):93-96.
[88]文才艺,吴元华,田秀玲.植物内生菌研究进展及其存在的问题[J].生态学杂志, 2004, 23(2):86-91.
[89] Shimizum, Nakagaway, Satoy,et al.Studies on endophytic actinomycetes (Ⅰ) :Streptomyces sp.isolated from rhododendron and its antifungal activity[J].Journal of General Plant Pathology,2000,66 (4):360-366.
[90]杨颖,陈华红,徐丽华.植物内生放线菌多样性研究[J].云南大学学报(自然科学版). 2008,30(S1):403-405.
[91] Benson D L, Silvester W B. Biology of Frankia strains actinomycete symbionts of actinorhizal plants[J].Mierobiol.Rev.1993,57:293-319.
[92]陈华红.傣药植物内生放线菌的多样性及多相分类研究[D].云南大学博士学位论文, 2007.
[93] Taeechowisan T,Peberdy J F,Lumyyong S.Isolation of endophytic actinomycetes from selected plants and their antifungal activity[J]. World J Microbiol Biotech, 2003, 19(4): 381-385.
[95] Coombs J T, Francoc M M. Isolation and identification of actinobacteria from surface sterilized wheat roots[J].Applied and Environmental Microbiology, 2003,69 (9) :5603 -5608.
[95]田新莉,曹理想,杨国武,等.水稻内生放线菌类群及其对宿主病原菌的抗性研究[J].微生物学报,2004,44(5):641-646.
[96] Sardi P, Saracehi M, Quaroni S, et al. Isolation of endophytie Streptomycea strains from surface sterilized roots[J].Appl Environ Mierobiol.1992,58:2691-2693.
[97] Amujo J M, Maeeheroni W, Aguilar C I , et al. Variability and interactions between endophytic bacteria and fungi isolated from leaf tissues of citrus rootstocks[J]. Can. J. Mierobiol, 2001, 47: 229- 236.
[98]陈华红,杨颖,姜怡,等.植物内生放线菌的分离方法[J].微生物学通报, 2006,33 (4):182-185.
[99]梁亚萍,宗兆锋,马强. 6株野生植物内生放线菌防病促生作用的初步研究[J].西北农林科技大学学报. 2007,35(07):131-136.
[100]李萌,张海涛,虞星炬,等.蔬菜内生菌的分离及其生防功能初探[J].江苏农业科学, 2003,(5):60-64.
[101]马强,宗兆锋,梁亚萍.凤县几种野生植物内生放线菌的分离筛选[J].西北农业学报. 2007,16(03):269-273.
[102] Castillo U F, Strobel G A, Ford E J, et al. Munumbicins, wide spectrum antibiotics produced by Streptomyces NRRL30562, endophytic on Kennedia nigricans[J]. Microbiology, 2002, 148: 2675-2685.
[103] Castillo U F, Strobel G A. Kakadumycuns, novel antibiotics from Streptomyces sp. NRRL30566, an endophyte of Grevillea pteridifolia[J]. FEMS Microbiology Letter, 2003,224:183-190.
[104] Pullen C, Schmitz P, Meurer K, et al. New and bioactive compound from Streptomyces strainsresiding in the wood of Celastraceae[J]. Planta, 2002, 216:162-167.
[105] Igarashi Y, Ogawa M, Sato Y, et al. Fistupyrone, a novel inhibitor of the infection of Chinese cabbage by Alternaria brassicioola, from Streptomyces sp.TP-A0569[J]. J Antibiotics, 2000,53: 1117-1122.
[106] Castillo U F,Browne L,Strobo G A,et al.Biologically active endophytic streptomycetes from Nothofagus spp.and other plants in Patagonia[J]. Mierob.Ecol. 2007,53:12-19.
[107]刘全永,胡江春,薛德林,等.海洋微生物生物活性物质研究[J].应用生态学报, 2002, 13(7) : 901-905.
[108]李文均,徐平,徐丽华,等.极端环境中的放线菌资源[J].微生物学报. 2003, 30(4): 125-126.
[109]姜成林,徐丽华,郭光远.云南若干地区土壤放线菌区系及资源考察V.高寒山区的放线菌[J].微生物学报, 1988,28(3): 198-200.
[110]杨宇容,徐丽华,李启任,等.低温环境中放线菌的研究[J].云南大学学报(自然科学版), 1997, 19(4): 397-402.
[111]姜成林等著.放线菌分类学[M].昆明:云南大学出版社.1995
[112] Schumann P, Prauser H, Rainey F A, et aL. Friedmanniella antarctica gen.nov., sp.nov., an LL-diaminopimelic acid-containing actinomycete from antarctics and stone[J]. Int J Syst Bacteriol. 1997,47:278-283.
[113] K?mpfer P, Rainey F A, Anderson M A, et aL. Frigoribacterium faenigen. nov, sp. nov., a novel psychrophilic genus of the family Microbacteriaceae[J]. Int J Syst Evol Microbiol. 2000,50:355-363.
[114] M?nnist M K, Schumann P, Rainey F A, et al. Subtercola boreus gen.nov., sp. nov., and Subtercola frigoraman sp. nov., two new psychrophilic actinobacteria isolated from boreal groundwater[J]. Int J Syst Evol Microbiol. 2000,50:1731-1739.
[115] Mevs U, Stackebrandt E, Schumann P, et al. Modestobacter multiseptatus gen. nov, a budding actinomycete from soils of the Asgard Range (Transantarctic Mountains)[J]. Int J Syst Evol Microbiol. 2000,50:337-346.
[116] Ruan J s, Tai A L, Zhou A M, et al. Actinopolyspora iragiensis sp., a new halophlic actinom-ycete islolated from soil[J]. Int J Syst Bacteriol, 1994,44:759-763.
[117] Tai A L, Rran J S. Nocardiopsis halophilasp nov, a new Halophilic Actiomycete isolated from soil[J]. Int J Syst Bacteriol, 1994,44:474-478.
[118] Cui X L, Mao P H, Tseng M, et al. Streptimonospora salina sp., a new member of the family Nocardiopsaceae[J]. Int J Syst Evol Microbiol, 2001,51:357-363.
[119]周培瑾,王大珍.亚嗜盐链霉菌新种的鉴定[J].微生物学报, 1983,23(3):216-219.
[120] Stackebrandt E, Koch C, Gvozdiak O, et al. Taxonomic dissection of the genus Micrococcus: Kocuria gen. nov, Nesterenkonia gen. nov, Kytococcus gen.nov, Dermacoccus gen. nov[J]. Int J Syst Evol Microbiol, 1995,45:682-692.
[121] Wang Y, Zhang Z S, Xu X L, et al. Actinopolymorpha singaporensis gen.nov, a novel actnomycete from the tropical rainforest of Singapore[J]. Int J Syst Evol Microbiol, 2001,51:467-473.
[122]张永光,李文均,张忠泽,等.碱性环境中的放线菌的生物学研究[J].微生物学通报, 2003, 30(1):73-77.
[123]张永光,唐蜀昆,李文均,等.嗜碱放线菌生理学特性的初步研究[J].微生物学通报, 2004, 31(1):30-35.
[124]沈玲,郭正彦,吴文君.极端环境中分离放线菌的方法[J].西北农业学报, 2005, 14(5):146-149.
[125]刘志恒,姜成林.放线菌现代生物学与生物技术[M].北京:科学出版社,2004.
[126] Meyer P S , KuPreaz J C, Kilian S G. Selection and evaluation of Astaxanth in Over-producing Mutans of Phaffia rhodoryma[J].World Journal of Microbiology and Biotechnology,1993,9:514-520.
[127] Hood K A, Zarembski D G. Mycophenolate mofetil: a uniqe immunosuppressive agent[J]. Am J Heath Systpharm,1997;54(3):285
[128] Adrio J L, Lopez M, Casqueiro J, Fernmdez C, et al. Electrophoretic karyo type of the as tax an thin-producing yeast Phaffia rhodozyma[J].Curr.Gener.1995,7:447-450.
[129]贾菊生,马德英.放线菌R1号菌株防治农作物病害的研究初报[J].新疆农业大学学报, 2001, 24(1):55-59.
[130]刘任,卢兆金.哈茨木霉T2菌株对辣椒土传真菌病害的控制作用[J].仲恺农业技术学院学报, 2003, 16 (l):6-11.
[131]邱思鑫,何红.内生芽抱杆菌TB2防治辣椒疫病效果及其机理初探[J].植物病理学报, 2004, 34(2):173-179.
[132]戴皖燕,关桂兰.两株对辣椒疫霉菌有拮抗作用的拮抗菌分泌蛋白的研究[J].中国生物防治, 2001,15(2):81-34.
[133]何美仙.寡雄腐霉和木霉对辣椒疫霉拮抗作用的初步研究[J].金华职业技术学院学报, 2002, 2:25-7.
[134]姚德明.新农用抗菌素的筛选[J].微生物学杂志, 1997,17(3):41- 43.
[135]方常福.抗病毒抗生素的筛选[J].微生物学杂志, 1996,16 (3):41- 46.
[136]郭予元.我国IPM研究进展回顾及对21世纪初发展目标的设想[J].植物保护, 1998, 24(1): 35- 38.
[137]范玲.微生物农药研究进展及产业发展对策[J].中国生物工程杂志, 2002,22(5):83-86.
[138]林壁润,谢双大,杨丽梅,等.抗生素2507对蔬菜卵菌病害的防治作用及稳定性研究[J].植物保护, 2000,26(2):11-13.
[139]吴军林,林炜铁,彭云平,等.防治植物病害的农用抗生素研究及应用[J].新农药, 2003,30(4):27-33
[140]王爱民,李晓刚,林壁润.杀虫抗生素的研究进展[J].广东农业科学, 2008,(8):76-78.
[141]沈寅初.农用抗生素研究开发的新进展[J].国外医药抗生素分册,1998,19(3):155- 160.
[142] Takahaskia, Kurasawas, Ikedad, et al. Altemicidin, a new acaricidal and antitumor substance [J]. Jantibot,1989,42:1556- 1561.
[143]王润华,涂国全,高勇生.梅岭霉素生物学特性及其产生菌特性的研究[J].江西农业大学学报, 1995,17(4):455- 461.
[144]陈华保.土壤放线菌农用活性菌株的筛选及研究[D].西北农林科技大学硕士学位论文, 2005.
[145]李洹,汪清民,黄润秋.多杀菌素的研究进展[J].农药学学报, 2003,5(2):1- 12.
[146]聂奎,曾中良,余鹏南,等.阿维菌素族抗寄生虫药物的研究[J].四川畜牧兽医学院学报, 2000, 14(4):42- 47.
[147]许建平,李德葆,吕忠平.新型抗生素类杀虫药物阿弗米丁研究与应用概况[J].浙江农业科学, 1996(3):136-137.
[148]许再福.生物药物素AVERMECTINS及其在农业害虫防治中的应用[J].微生物学通报, 1995, 22(2):112- 115.
[149]余凤玉,李振华,曾会才.抗真菌农用抗生素的研究进展[J].热带农业科学, 2005,25(1):60-65.
[150]商瑞,曾会才,毛佳.农用抗生素分离纯化的研究进展[J].广东农业科学, 2008, (2):124-126.
[151]安德荣,穆小倩.瑞拉菌素产生菌的鉴定[J].微生物学杂志, 2002,22(2):5-6.
[152]施跃锋,桑金隆,竺利红,等.新微生物农药抑霉菌素的研究[J].核农学报, 2004, 18(1):68-71.
[153]林壁润,谢双大,杨丽梅,等.抗生素2507对蔬菜卵菌病害的防治作用及稳定性研究[J].植物保护, 2000, 26(2):11-13.
[154]林壁润,谢双大,江学斌,等.抗生素2507对黄瓜疫病菌的抗生作用[J].植物保护学报, 2001, 28(2):113-117.
[155]郭永霞,孔祥清.天然除草活性化合物研究进展[J].植物保护, 2005, 31(6):11-16.
[156]彭浩,贺红武.从天然产物源寻找新的除草机制[J] .世界农药,2002 ,24(3) :1-5.
[157]余柳青,黄世文,等.微生物除草剂的研究和开发进展[A] .喻子牛主编.微生物农药及其产业化[C] .北京:科学出版社,2000,256-259.
[158]徐文平,陶黎明.生物除草剂9018的研究[J].上海化工, 2000,24(15):21-22.
[159]龙建友,姬志勤.西农No.24菌株发酵产物对反枝苋的除草活性初步研究[J].农药学学报, 2004, 6(1):89-92.
[160]龙建友,钱勇.一株放线菌代谢产物除草活性的初步研究[J].微生物学杂志, 2006, 26(1): 106-108.
[161]李韶菁,杜冠华.由一株放线菌产生的对谷胱苷肽转移酶具有抑制作用的活性化合物的研究[J].中国抗生素杂志. 2007, 32(7).
[162]刘睿,方玉春,段琳,等.海绵共附生放线菌Saccharopolyspora sp.nov中抗肿瘤活性成分的研究[J].中国抗生素杂志. 2006, 31(11): 646-649.
[163]徐文平,袁生,陶黎明,等.放线菌10885除草活性物质的分离鉴定[J].农药. 2007(12).
[164]沈显斌,赵雪平,王子洪.放线菌JXJ-35次生代谢产物的初步研究[J].九江学院学报. 2007, (06):69-71.
[165] Ben A M, Sioud S, Fourati B F, et al. Purification and structure determination of four bioactive molecules from a newly isolated Streptomyces sp. TN97 strain[J]. Process Biochemistry. 2006,41(7):1506-1513.
[166]刘宁,张辉,郑文,等.药用植物内生放线菌的生物活性及菌株D62的代谢产物分析[J].微生物学报. 2007,47(5).
[167] Attila K, Zsuzsanna S, IldikóL, et al. Production of FK520 by Streptomyces tubercidicus[J]. Microbiological Research. 2008, 163(6):624-632.
[168] Fourati-ben F L, Fotso S, Ben A M, et al. Purification and structure elucidation of antifungal and antibacterial activities of newly isolated Streptomyces sp. strain US80[J]. Research in Microbiology. 2005, 156(3): 341-347.
[169] Mukhopadhyay T, Nadkarni S R, Patel M V, et al. Maclafungin, a new antifungal macrocyclic lactone from Actinomycete sp.Y-8521050[J]. Tetrahedron. 1998,54(44): 13621-13628.
[170]陈光英,朱峰,林永成.海洋放线菌Streptomyces sp.V5产生的一个新的八元环内酯[J].有机化学. 2007, 27(9): 1159-1161.
[171]赵文英,顾谦群,朱伟明.海绵共附生放线菌SH6004菌株中抗肿瘤活性成分的研究[J].中国海洋大学学报(自然科学版). 2008,38(01):23-26.
[172]李德海,顾谦群,朱伟明,等.海洋放线菌11014中抗肿瘤活性成分的研究I.环二肽[J].中国抗生素杂志. 2005,30(8): 449-452.
[173]黄麟,张庆林,肖凤君,等.土壤放线菌3423代谢产物的分离纯化及结构鉴定[J].中国抗生素杂志. 2007, 32(5):320-322.
[174] Xi F L, Kim Y H, Jung J H, et al. Microbial transformation of the bioactive sesquiterpene, cyclonerodiol, by the ascomycete Penicillium sp. and the actinomycete Streptomyces sp.[J]. Enzyme and Microbial Technology. 2007,40(5): 1188-1192.
[175] Komatsu K, Tsuda M, Shiro M, et al. Brasilicardins B-D, new tricyclic terpernoids from actinomycete Nocardia brasiliensis[J]. Bioorganic & Medicinal Chemistry. 2004, 12(21): 5545-5551.
[176]吴少杰,李富超,秦松,等.海洋链霉菌M518产的新星形孢菌素衍生物的生物活性[J].高技术通讯. 2007,17(8):874-879.
[177]刘睿,朱天骄,朱伟明,等.海洋放线菌S1001中抗肿瘤活性成分的研究[J].中国抗生素杂志. 2006, 31(1):36-38.
[178]孙军利,王金来,王丽云,等.放线菌SPRI10304次级代谢产物中杀菌活性物质的分离提取及结构鉴定[J].化学与生物工程. 2008,25(01):43-47
[179]姬志勤,魏少鹏,杨春平,等.秦岭链霉菌发酵液中二丙酮胺的分离及抑菌活性初步研究[J].西北农林科技大学学报(自然科学版). 2008,36(02):148-152.
[180] Igarashi Y, Trujillo M E, Mart M E, et al. Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.[J]. Bioorganic & Medicinal Chemistry Letters. 2007, 17(13): 3702-3705.
[181] Hang Y B, Lee M Y, Park H J, et al. Isolation of putative polyene-producing actinomycetes strains via PCR-based genome screening for polyene-specific hydroxylase genes[J]. Process Biochemistry. 2007, 42(1):102-107.
[182] Hopmann C, Kurz M, Br M, et al. Isolation and structure elucidation of vancoresmycin--a new antibiotic from Amycolatopsis sp. ST101170[J]. Tetrahedron Letters. 2002,43(3): 435-438.
[183] Schumacher R W, Harrigan B L, Davidson B S. KahakamidesA and B, new neosidomycin metabolites from a marine-derived actinomycete[J]. Tetrahedron Letters. 2001,42(31): 5133-5135.
[184] Ohta E, Ohta S, Kubota N K, et al. Micromonospolide A, a new macrolide from Micromonospora sp.[J]. Tetrahedron Letters. 2001,42(25):4179-4181.
[185] Hardt I H, Jensen P R, Fenical W. Neomarinone, and new cytotoxic marinone derivatives, produced by a marine filamentous bacterium (actinomycetales)[J]. Tetrahedron Letters. 2000, 41 (13): 2073- 2076.
[186]Williams D E, Bernan V S, Ritacco F V, et al. HolyrinesA and B, possible intermediates in staurosporine biosynthesis produced in culture by a marine actinomycete obtained from the North Atlantic Ocean[J]. Tetrahedron Letters. 1999,40(40):7171-7174.
[187] Pettit G R, Tan R, Melody N, et al. Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete[J]. Bioorganic & Medicinal Chemistry. 1999,7(5): 895-899.
[188] Stadler M, Henkel T, M H, et al. Identification of alkaloids and polyketides in an Actinomycete by high-performance liquid chromatography with mass spectrometric and UV-Visible detection[J]. Journal of Chromatography A. 1998,818(2):187-195.
[189]李津成.在三江源区生态保护与可持续发展高级研讨会开幕式上的讲话.青海科技,2005(4): 4-7.
[190]刘欢,安德荣,慕小倩,等.土壤中抗真菌放线菌L H33发酵提取物活性研究[J].西北农林科技大学学报(自然科学版), 2009,31(1):145-150
[191]方羽生,杨卫华,张洪玲,等.放线菌对4种病原真菌的拮抗作用初探[J].广东农业科学. 2001(05):39-41.
[192]李小俊,成丽霞,吴彦彬,等.拮抗菌抗菌谱及发酵液拮抗能力测定的新方法[J].生物技术. 2007, 17(1):56-58.
[193]方中达.植病研究方法(第三版)[M].北京:中国农业出版社, 1998.
[194]慕立义.植物化学保护研究方法[M].北京:中国农业出版社, 1994.
[195]陈定花,朱卫刚,吴永刚.黄瓜灰霉病子叶筛选法初探研究[J].浙江化工,2000(S1):38-39.
[196]李树正,张素华.杀菌剂筛选方法的研究[J].农药, 1997, 36(9): 20-22.
[197]吴文君.植物化学保护实验技术导论[M].西安:陕西科技出版社, 1987: 141-145.
[198]农业部农药检定所生测室.农药田间药效试验准则(一)[M].北京:中国标准出版社,1993,10.
[199]张兴,王兴林.植物化学保护实验指导[M ].杨凌:西北农林科技大学出版社,2000,66-68.
[200]刘霞.昆虫病原线虫共生菌YL001菌株的代谢产物及其抑菌活性研究[D].西北农林科技大学博士学位论文,2006.
[201]乔宏萍.小麦内生细菌对小麦全蚀病的生物防治研究[D].西北农林科技大学博士学位论文,2006.
[202]宋虎.小麦全蚀病的生物防治研究及品种抗性鉴定[D].河南农业大学硕士学位论文,2004.
[203]李乐.放线菌株YB024对小麦全蚀病生物防治机制研究[D].河南农业大学硕士学位论文,2006.
[204]王小鹏. 20﹪福·邻悬浮种衣剂防治小麦纹枯病和全蚀病初步研究[D].中国农业大学硕士学位论文,2007.
[205] Michael T M, Aharon O. Thermophilic and halophilic extremophiles[J]. Current Opinion in Microbiology, 1999,2:265-269.
[206]李子东,藏立华.极端微生物:一种新型的酶资源[J].微生物学报,2004,5:89-92.
[207]钱存柔,董碧红.微生物学基础知识和实验指导[M].北京:科学出版社, 1979.
[208]程丽娟,薛泉宏.微生物学实验指导[M].西安:兴国图书出版社,2000.
[209]刘会强,张立丰,韩彬,等.嗜盐菌的研究新进展[J].新疆师范大学学报(自然科学版), 2005,24(3):84-88.
[210]阎旭光,吴剑波. 16SrRNA在放线菌分子鉴别和分类中的作用及RFLP和RAPD的应用[J].国外医药抗生素分册, 1997,18(6):409-417.
[211]张妍,张建丽,牛宁昌.放线菌的分子分类[J].微生物学杂志, 2007, 27(4):79-82.
[212]马邦亚,杨俊秀,曹支敏.放线菌分类的历史和研究现状[J].西北林学院学报,1999, 14 (3) : 76-80.
[213]王意敏,刘志恒.放线菌的多相分类[J].微生物学通报, 1999,26(2):137-140.
[214]张燕新,吴莹,张迹,等.高温放线菌分类的研究进展[J].微生物学杂志, 2007, 27(1):64-69.
[215]张建丽,刘志恒.诺卡氏菌型放线菌的分类[J].微生物学报, 2001,41(4):515-517.
[216]李文均,张忠泽,姜成林.高温放线菌属分类研究进展[J].微生物学报, 2002, 42(6): 759-763.
[217]张纪忠,黄静娟.微生物分类学[M].上海:复旦大学出版社, 1990.
[218]康振生.植物病原真菌的超微结构[M].北京:中国科学技术出版社,1996.
[219]中国科学院微生物研究所放线菌分类组编著.链霉菌鉴定手册[M].北京:科学出版社,1975.
[220]徐平,李文均,徐丽华.微波法快速提取放线菌基因组DNA[J].微生物学通报. 2003, 30(4): 82-85.
[221]姜淑梅,张龙,戴世鲲,等.一种简单、有效的适于PCR操作的放线菌DNA提取方法[J].生物技术. 2007, (01):39-41.
[222]黄培堂等译.分子克隆实验指南(第三版)[M].北京:科学出版社,2002.
[223]阎逊初.放线菌的分类和鉴定[M].北京:科学出版社,1992.
[224]周煜. 16S rRNA序列分析法在医学微生物鉴定中的应用[J].生物技术通讯. 1999(04): 297-305.
[225]张晓君,冯清平,白玲.分子生态学方法在微生物多样性研究中的应用[J].微生物学通报. 1999,29(01):68-70.
[226]徐丽华,李文均,张玉琴,等.关于细菌新分类单元描述的标准化[J].微生物学通报, 2004, 31(6):126-127.
[227] Palmqvist, Eva, Hahn H, et al. Fermentaion of lignocellulosic hydrolysatesⅡ: inhibitors and mechanisms of inhibition[J]. Bioresource Technology, 2000,74(1):25-33.
[228] Kiers J L, Vanlaeken A E A, Rombouts F M, et al. vitro digestibility of Bacillus fermented soya bean [J].International Journal of Food Microbiology, 2000,60(3):163-169.
[229]王永宏,张兴. Xenorhabdus nematophila YL001培养基筛选和培养条件优化[J].生物加工过程, 2006,4(2):58-63.
[230] Han Y, Li Z, Miao X, et al. Statistical optimization of medium components to improve the chitinase activity of Streptomyces sp. Da11 associated with the South China Sea sponge Craniella australiensis[J]. Process Biochemistry Metabolic Engineering. 2008, 43(10): 1088-1093.
[231] Purama R K, Goyal A. Screening and optimization of nutritional factors for higher dextransucrase production by Leuconostoc mesenteroides NRRL B-640 using statistical approach[J]. Bioresource Technology. 2008, 99(15): 7108-7114.
[232] Khosravi D K, Zoghi A. Comparison of pretreatment strategies of sugarcane baggase: Experimental design for citric acid production[J]. Bioresource Technology. 2008, 99(15): 6986-6993.
[233] Talpur F N, Bhanger M I, Rahman A U, et al. Application of factorial design in optimization of anion exchange resin based methylation of vegetable oil and fats[J]. Innovative Food Science & Emerging Technologies. 2008, 9(4): 608-613.
[234] Li X Y, Liu Z Q, Chi Z M. Production of phytase by a marine yeast Kodamaea ohmeri BG3 in an oats medium: Optimization by response surface methodology[J]. Bioresource Technology. 2008, 99(14): 6386-6390.
[235] Imandi S B, Bandaru V V, Somalanka S R, et al. Application of statistical experimental designs for the optimization of medium constituents for the production of citric acid from pineapple waste[J]. Bioresource Technology. 2008, 99(10): 4445-4450.
[236]褚以文.微生物培养基优化方法及其OPTI优化软件[J].国外医药抗生素分册, 1999, 20(2): 58-60, 66.
[237]张字镭,党璇,贺平安.利用Pearson相关系数定量分析生物亲缘关系[J].计算机工程与应用, 2005, 33:79-83.
[238]高修功,王超,章克昌.数学统计法快速优化假单胞菌脂肪酶发酵条件[J].微生物学通报, 1998, 25(2):94-97
[239] Weuster D. Experimental design for fermentation media development: statistical design or global random search [J]. J Bioscience and Bioengineering, 2000, 90 (5): 473-483.
[240] Ambat P, Ayyanna C. Optimizing medium constituents and fermentation conditions for citric acid production from palmyra jaggery using response surface methods[J]. Journal of Microbiology &Biotechnology, 2001,17:331-335.
[241] Ratnam B V V, Narasimha Rao M. Dmodar Rao M, et a1. Optimization of fermentation conditions for the production of ethanol from sago starch using response surface methodology[J]. Journal of Microbiology & Biotechnology, 2003,19:523-526.
[242] Trupkin S , Levin S , Forchiassin F. Optimization of a culture medium for ligninolytic enzyme production and synthetic dye decolorization using response surface methodology[J]. Journal of Industrial Microbiology Biotechnology, 2003,30:682-690.
[243]朱昌雄.农用抗生素——中生菌素[J].精细与专用化学品, 2002,(16):14-17.
[244] Nobili M De, Contin M, Mondini C, et al.Soil microbial biomass is triggered into activity by trace amounts of substrate[J].Soil Biology and biochemistry.2001,33:1163-1170
[245]陈毓荃.生物化学实验方法和技术[M].北京:科学出版社,2002.
[247] Fernando P. The historical delivery of antibiotics from microbial natural products-Can history repeat [J]. Biochem Pharmacol, 2006,71:9 81-990
[248]王俊儒.天然产物提取分离与鉴定技术[M].西北农林科技大学,2003.
[249]周德庆.微生物实验手册[M].上海:上海科学技术出版社,1986.
[250]常建华,董绮功.波谱原理及解析[M].科学出版社,2001.
[251]宁永成.有机化合物结构鉴定与有机波谱学[M].科学出版社,2000.
[252]赵瑶兴,孙祥玉编.有机分子结构光谱鉴定[M].科学出版社,2002.
[253] Robert M S, Francis X W, David J K.有机化合物的波普解析[M].华东理工大学出版社,2007.
[254] Swarna A G, Gordon W R, Bruce C B, et al. Phenazine-1-carboxamides: Structure–cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain[J]. Bioorganic & Medicinal Chemistry, 2006, 14(4):1160–1168.
[255]谢一辉,邓鹏,张叶青.安痛藤化学成分研究[J].中草药, 2009,32(2):210-213.
[256]赵晓亚,孙汉董,吴继洲.冷水七根茎的化学成分研究[J].中国中药杂志, 2005, 30(8): 584-586.
[257]辛菲,金艺淑,沙沂.马鞭草化学成分研究[J].中国现代中药,2008,10(10):21-23.
[258]李厚金,林永成,刘晓红.红树林内源真菌2524号的肽类成分(Ⅰ).中山大学学报(自然科学版), 2002,41(1):110-112.