摘要
HRV和BPV已成为评价心血管系统调节功能的重要参数,但这仅是心血管系统变异的侧面表现。若全面深入理解其本质,无论在机制上还是在处理手段方面都存在大量的问题需要解决。本文对其有关的理论问题进行了较为深入地研究。主要工作与结果如下:
1.血管容积变异的提出
作者详尽地总结了心血管系统变异的机制与临床的研究进展和所存在的问题,在此基础上作者认为血管容积变异历程所含信息更为丰富,并能将心脏与微循环之间联系起来,初步观察已证实了该观点的正确性。
根据HRV和BPV的低频成分与微循环自主舒缩频带重叠这一事实,它们二者之间可能存在某种联系,而界于心脏和微循环之间的血管容积变异应包含更丰富的信息,因为它既与心脏泵血有关,又与外周大血管和微动脉自主舒缩有关。比较相关的研究后发现,肢体阻抗容积图在研究心血管系统变异方面具有独特的优势:①对机体干扰比较小,这可避免血压测量中充放气所给患者带来的不适,以及由此而引起的对自主神经的干扰;②阻抗容积图容易得到整个时程信息,这避免血压变异中仅依靠舒张压、收缩压和平均压几个参数的片面性;③阻抗容积图的不同特征量受心脏、血管、微循环影响程度不同,因而便于从多视角观察心血管系统变异。
对肢体阻抗血流图的拍拍变异进行了初步分析,观察到了如下几个方面的现象:①阻抗容积图整体以及大多数的特征量也存在类似HRV和BPV的LF和HF谱峰,特别是脉率变异与HRV基本相似;②阻抗容积图低频变异有类似宽带的特性;③阻抗容积图的重搏前波变异LF功率大于其他波LF功率,其原因可能涉及微循环的自主舒缩:④HRV极低频与血流极低频功率谱之间存在明显差异,HRV表现出典型的1/f~β现象,而血流图极低频成分随频率趋于零而下降。
2.利用阈值收缩法直接去除色噪
建立了直接由色噪功率谱估计小波变换各尺度噪声方差的公式,这既避开了现有文献去除色噪方案中的白化滤波器设计,又避免了两次滤波操作,可有效(?)减少运算量。同时,由于未涉及白化滤波,故也不存在因滤波器与色噪模型不匹配所带来的精度问题。将这种方法应用于阻抗血流图去噪,取得良好效果。
3.特征点检测与时频参数精细估计
提出了奇异点按对称性分类的概念,按照这个概念,奇异点检测中的小波选择更具目的性和指导性,即对中心对称类型奇异采用偶函数小波,而轴对称型奇异采用奇函数小波,可使小波变换在奇异点处出现极大值。将小波变换应用于心电图的R波检测,比较了采用Marr小波和二次样条小波的变换在R波位置的局部性态。通过数值试验发现,把R波的升支(或降支)作为中心对称性奇异比把R波作为δ类奇异更为合理。
Heart rate variability (HRV) and blood pressure variability (BPV) have been taken as important roles in evaluating the regulating function of cardiovascular system, but they are not the whole manifestation of cardiovascular system variability (CVSV). No matter in the mechanism or the analysis method, there are still a lot of problems needing to be solved. Some of these problems are studied in depth in this dissertation.
1. The presentation of vascular plethysmogram variability
The progresses and issues in the mechanism research and clinical study of CVSV were reviewed systematically, and the advantages of vascular plethysmogram (VP) were summarized. The most important potentiality of the VP measurement is capable to observe the comprehensive information of the heart linked with microcirculation and vasomotion. Compared with the blood pressure meansurement, the whole time-history of VP can be obtained without extraneous tension to the patient being tested, hence CVSV is prone to be investigated by means of vascular plethysmogram variability(VPV).
In this dissertation, the VPV was investigated in preliminary, and many interesting phenomena were found. Firstly, VPV and most of VP characteristic parameters' beat-beat variability possess the same LF band and HF band as HRV and BPV. Secondly, LF of VPV exhibits width-like band feature. Thirdly, The LF power of tidal wave amplitude variability is larger than that of other parameters. Lastly, the very low frequency band of HRV behaves as the typical power law, but not of VPV.
2. The direct suppressing color-noise by threshold shrinkage method
The key to threshold shrinkage method is threshold estimating, which were accomplished by direct estimation from color noise spectrum in this dissertation. Filter designing and twice filtering in the literature method are not necessary in this algorithm.
3. Characteristic point detecting and high resolution estimating of parameters
The concept of symmetry property of singular point was proposed. According to this concept, blindness can be avoided in wavelet selection in characteristic point detecting, i.e., to make wavelet transform maximum at singular point, odd wavelet is used for centrosymmetry singular type, even wavelet for the axially symmetry.
The continuous wavelet transform were used to detect the R-peaks of electrocardiographic(ECG). The R-peak local traits of wavelet transform with Marr
引文
1 Akselrod( 1981) S.Gordon D.Pernpruner S,et al. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 1981,213(10): 220-222
2 Benbow(1995) SJ,Pryce DW.Noblett K,et al. Flow motion in peripheral diabetic neuropathy. Clin Sci. 1995,88(2): 191-196
3 Bernardi(1994) L.Leuzzi S.Radaelli A,et al. Low-frequency spontaneous fluctuations of RR interval and blood pressure in conscious humans: a baroreceptor or central phenomenon? Clin Sci. 1994,87(6): 649-654
1 Bernardi(1997) L; Rossi M; Leuzzi S; et al. Reduction of 0.1 Hz microcirculatory fluctuations as evidence of sympathetic dysfunction in insulin-dependent diabetes.Cardiovasc Res. 1997 ,34(1): 185-91
4 Bertuglia(1996) S.Colantuoni A,Arnold M,et al. Dynamic coherence analysis of vasomotion and flow motion in skeletal muscle microcirculation. Microvasc Res. 1996,52(3): 235-244
5 Brauer(1999) K.Hahn M. Nonlinear analysis of blood flux in human vessels. Phys Med Biol 1999,44(7): 1719-1733
6 Casolo(1991) G,Balli E,Fazi A,et al. Twenty-four spectral analysis of heart rate variability in congestive heart failure secondary to coronary artery disease. Am J Cardiol. 1991,67: 1154-1158
7 Corcoran(1987) JS,Yudkin JS. Loss of spontaneous variability of fingertip anastomotic blood flow in diabetic autonomic neuropathy. Clin Sci. 1987,72(5): 557-562
8 Davidson(1997) S.Reina N,Shefi O.Spectral analysis of heart rate fluctuations and optimum thermal management for low birth weight infants. Med Biol Eng Comput. 1997,35(6): 619-625
9 Dykes(1986) FD,Ahmann PA,Baldzer K,et al. Breath amplitude modulation of heart rate variability in normal full term neonates. Pediatr Res. 1986,20(4): 301-308
10 Fallen(1988) EL.Kamath MV.Ghista DN,et al. Spectral analysis of heart rate variability following human heart transplantation: Evidence for functional reinnervation. J Auton Nerv Syst. 1988,23: 199-206
11 Fleisher(1996) LA.Frank SM.Sessler DI.et al. Thermoregulation and heart rate variability. Clin Sci. 1996 90(2): 97-103
12 Goldberger( 1990) AL,Rigney DR.West BJ. Chaos and fractals in human physiology. Scientifc American. 1990,262(Feb): 42-49
13 Goldberger(1992) AL. Fractal Mechanisms in the electrophysiology of heart. IEEE Eng Med Biol. 1992,11(6): 46-52
14 Grasso(1995) R,Rizzi G.Schena F,et al. Arterial baroreceptors are not essential for low frequency oscillation of arterial pressure. J Auton Nerv Syst. 1995,50(3):323-331
15 Groome(1994) LJ.Mooney DM,Bentz LS,et al. Spectral analysis of heart rate variability during quiet sleep in normal human fetuses between 36 and 40 weeks of gestation. Early Hum Dev. 1994,38(1): 1-9.
16 Hagerman( 1996) I,Berglund M,Lorin M,et al. Chaos-related deterministic regulation of heart rate variability in time- and frequency domains: effects of autonomic blockade and exercise. Cardiovasc Res. 1996,31(3): 410-418
17 Haker(2000) E ,Egekvist H.Bjerring P. Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects. J Auton Nerv Syst. 2000,79(1): 52-59
18 Hayano(1991) J.Sakakibara Y,Yamada A,et al. Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. Am J Cardiol. 1991,67(2): 199-204
19 Honzikova(1992) N.Fiser B,Honzik J. Noninvasive determination of baroreflex sensitivity in man by means of spectral analysis. Physiol Res. 1992,41(1): 31-37
20 Inoue(1991) K.Miyake S,Kumashiro M.et al. Power spectral analysis of blood pressure variability in traumatic quadriplegic humans. Am J Physiol. 1991.260(3 Pt 2): H842-847
21 Iyengar(1996) N.Peng CK.Morin R,et al. Age-related alterationsin the fractal scaling of cardiac interbeat interval dynamics. Am J Physiol. 1996,271(4 Pt 2): R1078-1084
22 Jahnukainen(1999) T.Lindqvist A Jalonen J;Responsiveness of cutaneous vasculature to thermal stimulation during phototherapy in neonatal jaundice. Eur J Pediatr. 1999,158(9): 757-760
23 Kardos(1996) A,Halmai L,Rudas L,et al. Changes in blood pressure and heart period variability in patients with recent acute myocardial infarction. Clin Sci. 1996,91(S): 52-55
24 Khadra( 1997) LM,Maayah TJ.Dickhaus H. Detecting chaos in heart rate variability signals in human cardiac transplant recipients. Comput Biomed Res. 1997,30(3): 188-199
25 Kobayashi(1982) M.Musha T. 1/fFluctuation of heart beat period. IEEE Trans Biomed Eng. 1982,29(6): 456-457
26 Kvernmo( 1998) HD.Stefanovska A,Bracic M,et al. Spectral analysis of the laser Doppler perfusion signal in human skin before and after exercise. Microvasc Res. 1998,56(3): 173-182
27 Lindqvist(1983) A,Oja R,Hellman O,et al. Impact of thermal vasomotor control on the heart rate variability of newborn infants. Early Hum Dev. 1983 .8(1): 37-47.28 Lindqvist(1989) A,Parviainen P.Kolari P,et al. A non-invasive method for testing neural circulatory control in man. Cardiovasc Res. 1989,23(3): 262-272
29 Lindqvist( 1990a) A,Jalonen J.Parviairien P,et al. Effect of posture on spontaneous and thermally stimulated cardiovascular oscillations. Cardiovasc Res. 1990,24(5): 373-380
30 Lindqvist( 1990b) A. Noninvasive methods to study autonomic nervous control of circulation. Acta Physiol Scand Suppl. 1990,588: 1-107
31 Lindqvist(1991) A,Parviainen P.Jalonen J,et al. Clinical testing of thermally stimulated cardiovascular oscillations in man. Cardiovasc Res. 1991,25(8): 666-675
32 Lucini(1994) D,Pagani M.Mela GS,et al. Sympathetic restraint of baroreflex control of heart period in normmotensive and hypertensive subjects. Clin Sci. 1994,86(5):547~556
33 Mohler(1988) FS,Heath JE. Oscillating heat flow from rabbit's pinna. Am J Physiol. 1988,255(3 Pt 2): R464-469
34 Montano(1998) N,Cogliati C,Porta A,et al. Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. Circulation. 1998,98(14): 1394-1399
35 Mortara(1997) A,Sleight P,Pinna GD.et al. Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability. Circulation. 1997,96(1):246~252
36 Nitzan(1994) M,de Boer H,Turivnenko S,et al. Power spectrum analysis of spontaneous fluctuations in the photoplethysmographic signal. J Basic Clin Physiol Pharmacol. 1994,5(3-4): 269-276
37 Nitzan(1998) M.Babchenko A,Khanokh B,et al. The variability of the photoplethysmographic signal-a potential method for the evaluation of the autonomic nervous system. Physiol Meas. 1998,19(1): 93-102
38 Omboni(1996) S,Parati G,Di Rienzo M,et al. Blood pressure and heart rate variability in autonomic disorders: a critical review. Clin Auton Res. 1996,6(3): 171-182
39 Ori(1992) Z,Monir G,Weiss J,et al. Heart rate variability. Frequency domain analysis. Cardiol Clin. 1992,10(3): 499-537
40 Otsuka(1997) K,ComeIissen G.Halberg F. Orcadian rhythmic fractal scaling of heart rate variability in health and coronary artery disease. Clin Cardiol. 1997,20(7): 631-638
41 Pagani(1986) M,Lombardi F. Power Spectrum analysis of heart and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dogs. Circ Res. 1986.59(1): 178-193
42 Papavasiliou(1995) SS,Brue T.Jaquet P,et al. Pattern of prolactin diurnal secretion in normal humans: evidence for nonlinear dynamics. Neuroendocrinology. 1995,62(5): 444-453
43 Pape(1997) G-Le,Giacomini H,Swynghedauw B,et al. A statistic alanalysis of" sequences of cardiac interbeat intervals does not support the chaos hypothesis. J Theor Biol. 1997,184(2): 123-131
44 Penzel( 1995) T. Blood pressure analysis. J Sleep Res. 1995,4(S 1): 15-20
45 Prank(1994) K.Harms H.Dammig M,et al. Is there low-dimensional chaos in pulsatile secretion of parathyroid hormone in normal human subjects? Am J Physiol. 1994.266(4 Pt 1): E653-658
46 Radaelli(1996) A.Valle F,Falcone C.et al. Determinants of heart rate variability in heart transplanted subjects during physical exercise. Eur Heart J. 1996,17(3): 462-471
47 Radaelli(1999) A.Perlangeli S.Cerutti MC,et al. Altered blood pressure variability in patients with congestive heart failure. J Hypertens. 1999,17(12): 1153-1161
48 Robinson(1997) TG.James M,Youde J,et al. Cardiac baroreceptor sensitivity is impaired after acute stroke. Stroke. 1997,28(9): 1671-1676
49 Saul(1977) JP. Analysis of long term heart rate variability: Methods,1/f scaling and implications. Silver springs.Md. IEEEComputer Society Press. 1977: 49-54
50 Schiavi(2000) R,Robertson D.Malliani A,et al. Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus. Circulation. 2000,101(8): 886-892
51 Schuppert(1994) F,Diegelmann B,Geest T. Loss of variability in Graves' disease: stimulatory TSH-receptor antibodies bind to the TSH-receptor in a continued,non-pulsatile and non-chaotic fashion. Chronobiologia. 1994,21(1-2): 21-32
52 Shiomi(1996) T,Guilleminault C,Sasanabe R,et al. Augmented very low frequency component of heart rate variability during obstructive sleep apnea. Sleep. 1996,19(5): 370-377
53 Stansberry(1996) KB.Shapiro SA,Hill MA,et al. Impaired peripheral vasomotion in diabetes. Diabetes Care. 1996,19(7): 715-721
54 Stucker(1998) M,Steinbrugge J,Ihrig C,et al. Rhythmical variations of haemoglobin oxygenation in cutaneous capillaries.Acta Derm Venereol. 1998,78(6): 408-411
55 Sugihara(1996) G.Allan W.Sobel D,et al. Nonlinear control of heart rate variability in human infants. Proc Natl Acad Sci U.S.A. 1996,93(6): 2608-2613
56 Takei(1992) Y. Relationship between power spectral densities of PP and R-R intervals. Ann Physiol Anthropol. 1992,11(3): 325-33257 Tallarida(1994) RJ,Freeman KA. Chaos and control in mass action binding of endogenous compounds. Ann Biomed Eng. 1994, 22(2): 153~161
58 Thayer(1997) JF, Nabors-Oberg R, Sollers JJ. Thermoregulation and cardiac variability: a time-frequency analysis. Biomed Sci Instrum 1997,34:252~256
59 Thompson(1993) CR,Brown JS,Goe H,et al. Heart rate variability in healthy term newborns: the contribution of respiratory sinus arrhythmia. Early Hum Dev. 1993,31(3): 217~228
60 Verwaerde(1996) P, Senard JM,Mazerolles M,et al. Spectral analysis of blood pressure and heart rate,catecholamine and neuropeptide Y plasma levels in a new model of neurogenic orthostatic hypotension in dog. Clin Auton Res. 1996,6(2): 75~82
61 Veglio(1999) F, Molino P, Cat Genova G,et al. Impaired baroreflex function and arterial compliance in primary aldosteronism. J Hum Hypertens. 1999,13(1): 29~36
62 Xiu(1985) RJ,Intaglietta M.Computer analysis of the microvascular vasomotion. Pflugers Arch. 1985,403(3): 289~295
63 Yamamoto(1994) Y, Hughson RL. On the fractal nature of heart rate variability in humans: effects of data length and β-adrenergic blockade. Am J Physiol. 1994,266(1 Pt 2): R40~49
64 Yang(1998) MW, Kuo TB,Lin SM,et al. Power spectral analysis of arterial blood pressure after spinal anesthesia. Acta Anaesthesiol Sin. 1998,36(1): 3~10
65 Yamamoto(1991) Y, Hughson RL. Coarse-graining spectral analysis: new method for studying heart rate variability. J Appl Physiol. 1991,71(3): 1143~1150
66 Yamamoto(1993a) Y, Hughson RL. Extracting fractal components from time series. Phyica D. 1993,68: 250~264
67 陈晓辉(1985).生物阻抗相对检测灵敏度分布法用于检测和区分在体浅表动脉运动和截面变化的实验研究.学位论文.中国协和医科大学.1985:36-37
68 程小明(1998).心肌电活动的变异性与心电图形态微变的逐拍分析[学位论文].中国协和医科大学.
69 傅骢远(1994),牛欣.中医脉象今释.北京:华夏出版社.1994:37~41
70 韩峰(1988).浅表动脉血压波形、动脉张力动态区分检测的实用化研究.[学位论文].中国协和医科大学.1988
71 李澈(1999).心肌兴奋的发生和传播.见苏静怡等:心脏从基础到临床.北京:北京医科大学/中国协和医科大学出版社.1999:154~197
72 李磊(1994).针灸治疗时间学.见:何绍雄等,时间药理学与时间生物治疗学.天津:天津科学技术出版社.1994:286~315
73 刘泰槰(2000).心肌细胞电生理学.北京:北京大学出版社.2000.
74 司马迁[汉](1988).史记.湖南:岳麓出版社.1988:747~760.
75 王建宁(1984).张力与压力无损区分检测系统的开发及其试用于寸口桡动脉的可行性初步观察.[学位论文].中国协和医科大学.1984
76 吴杰(1998),张开兹,陆再英.心率变异性.见张开滋等:心电信息学.北京:科学技术文献出版社.1998:159~178
77 修瑞娟(1981).金黄地鼠颊囊微血管管径变化电视连续扫描观察.1981,61(5):270~273
78 杨洁秋(1991).应用极化阻抗传感器进行生物医学测量的初步研究.[学位论文].中国协和医科大学.1991
79 叶继伦(1999),郑崇勋,黄燕.心率变化对心电信号各波间期的影响分析.生物医学工程学杂志.1999,16(1):50~53
80 张坚(1995).大鼠肠系膜微淋巴管自律运动特征的研究.中华医学杂志.1995,75(5):262~265
81 张笑平(1994),胡丽华.中医时间治疗学.见:何绍雄等,时间药理学与时间生物治疗学.天津:天津科学技术出版社.1994:270~2851 Asano(1980) M, Ohkubo C, Sawanobori K, et al. Cutaneous microcirculatory effects of various vasodilator agents on the conscious rabbit, with special regard to changes in the rhythmic property of vasomotion. Biochem Exp Biol. 1980,16(4):341~348
2 Avolio(1983) AP, Chen SG, Wang RP. Effects of aging on changing arterial compliance and (?)ft ventricular load in a northern Chinese urban community. Circulation. 1983,68(1):50~58。
3 Benbow(1995) SJ, Pryce DW, Noblett K, et al. Flow motion in peripheral diabetic neuropathy. Clin Sci (Colch). 1995,88(2): 191~196
4 Brembilla-Perrot(1997) B, Lucron H, Schwalm F, et al. Mechanism of QRS electrical alternans. Heart. 1997, 77(2): 180~182
5 Butler(1993) GC, Yamamoto Y, Xing HC. Heart rate variability and fractal dimension during orthostatic challenges. J Appl Physiol. 1993, 75(6): 2602~2612
6 Butler(1994a) GC, Yamamoto Y, Hughson RL. Fractal nature of short-term systolic BP and HR variability during lower body negative pressure. Am J Physiol. 1994, 267(1 Pt 2): R26~33
7 Butler(1997) GC, Ando S, Floras JS. Fractal component of variability of heart rate and systolic blood pressure in congestive heart failure. Clin Sci Colch. 1997, 92(6): 543~550
8 Cevese(1995) A, Grasso R, Poltronieri R, et al. Vascular resistance and arterial pressure low-frequency oscillations in the anesthetized dog. Am J Physiol 1995,268(1 Pt 2):H7~16
9 Corcoran(1987) JS, Yudkin JS. Loss of spontaneous variability of fingertip anastomotic blood flow in diabetic autonomic neuropathy. Clin Sci. 1987.72(5): 557~562
10 Dai(1985) K, Xue H, Dou R, Fung YC. On the detection of messages carried in arterial pulse waves. J Biomech Eng. 1985,107(3): 268~273
11 DePaola(1993) R, Wang HX, Norwood WI. Fractal structure underlying patterns of premature heart beats. Am J Physiol. 1993, 265(5 Pt 2): H1603~1613
12 Fleisher(1996) LA, Frank SM, Sessler DI, et al. Thermoregulation and heart rate variability. Clin Sci (Colch) 1996 Feb. 90(2): 97~103
13 Grasso(1995) R, Rizzi G, Schena F, et al. Arterial baroreceptors are not essential for low frequency oscillation of arterial pressure. J Auton Nerv Syst. 1995, 50(3): 323~331
14 Griffith(1996) TM. Temporal chaos in the microcirculation. Cardiovasc Res 1996,31(3): 342~358
15 Hagerman(1996) I, Berglund M, Lorin M, et al. Chaos-related deterministic regulation of heart rate variability in time-and frequency domains: effects of autonomic blockade and exercise. Cardiovasc Res. 1996, 31(3): 410~418
16 Hirayama(1993) Y. Saitoh H, Atarashi H. et al. Electrical and mechanical alternans in canine myocardium in vivo. Dependence on intracellular calcium cycling. Circulation. 1993, 88(6):2894~2902
17 Iyengar(1996) N, Peng CK, Morin R, et al. Age-related a(?)erationsin the fractal scaling of cardiac interbeat interval dynamics. Am J Physiol. 1996, 271(4 Pt 2): R1078~1084
18 Kobayashi(1982) M, Musha T. l/f Fluctuation of heart beat period. IEEE Trans Biomed Eng. 1982, 29(6): 456~457
19 Kvernmo(1998) HD. Stefanovska A, Bracic M, et al. Spectral analysis of the laser Doppler perfusion signal in human skin before and after exercise. Microvasc Res 1998.56(3): 173~182
20 Larsen(1997) PD, Harty M, Thiruchelvam M, et al. Spectral analysis of AC and DC components of (?)e pulse photoplethysmograph at rest and during induction of anaesthesia. Int J Clin Monit Comput. 1997,14(2): 89~95
21 Larsson(1993) SE, Cai H, Oberg PA. Continuous percutaneous measurement by laser-Doppler flowmetry of skeletal muscle microcirculation at varying levels of contraction force determined electromyographically. Eur J Appl Physiol. 1993,66(6): 477~482.
22 McDonald(1974). Blood flow in arteries. London: Edward Arnold.1974
23 Nitzan(1994) M, de Boer H, Turivnenko S, et al. Power spectrum analysis of spontaneous fluctuations in the photoplethysmographic signal. J Basic Clin Physiol Pharmacol. 1994,5(3-4): 269~276
24 Nitzan(1998) M, Babchenko A, Khanokh B, et al: The variability of the photoplethysmographic signal—a potential method for the evaluation of the autonomic nervous system. Physiol Meas. 1998,19(1): 93~102
25 Nitzan(1999) M, Babchenko A, Khanokh B. Very low frequency variability in arterial blood pressure and blood volume pulse. Med Biol Eng Comput. 1999. 37(1): 54~58
26 O'Rourke(1982) MF. Arterial function in health and disease. Edinburgh, London, Melbourne and New??York: Churchill Livingstone.
27 Pagani(1986)M, Lombardi F. Power Spectrum analysis of heart and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dogs. Circ Res. 1986, 59(1): 178~193
28 Parthimos(1996) D, Edwards DH, Griffith TM. Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow. Cardiovasc Res 1996, 31(3): 388~399
29 Rosenbaum(1994) DS, Jackson LE, Smith JM, et al. Electrical alternans and vulnerability to ventricular arrhythmias, N Engl J Med. 1994, 330(4): 235~241
30 Rubenstein(1995) DS, Lipsius SL. Premature beats elicit a phase reversal of mochanoelectrical alternans in cat ventricular myocytes. A possible mechanism for reentrant arrhythmias. Circulation. 1995, 91(1):201~214
31 Saul(1977) JP. Analysis of long term heart rate variability: Methods, 1/f scaling and implications. Silver springs, Md. IEEE Computer Society Press. 1977: 49~54
32 Shimizu(1999) W, Antzelevitch C. Cellular and ionic basis for T-wave alternans under long-QT conditions. Circulation. 1999, 99(11): 1499~1507
33 Stansberry(1996) KB, Shapiro SA, Hill MA, et al. Impaired peripheral vasomotion in diabetes. Diabetes Care. 1996,19(7): 715~721
34 Stauss(1998) HM, Anderson EA, Haynes WG, et al. Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol. 1998, 274(4 Pt 2): H1277~1283
35 Stefanovska(1999) A, Bracic M, Kvernmo HD. Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique. IEEE Trans Biomed Eng. 1999,46(10): 1230~1239
36 Thayer(1997) JF, Nabors-Oberg R, Sollers JJ. Thermoregulation and cardiac variability: a time-frequency analysis. Biomed Sci Instrum 1997,34:252~256
37 Ueda(1995)K. Analysis of arterial pulse propagation time variability for studying wave transmitting properties of arteries. Masui. 1995,44(3): 388~395
38 Ursino(1996) M, Cavalcanti S, Bertuglia S, et al. Theoretical analysis of complex oscillations in multibranched microvascular networks. Microvasc Res. 1996,51(2): 229~249
39 West(1987) BJ, Golderberg AL. Physology in fractal dimensions. Am Sci. 1987, 75: 354~365
40 Yamamoto(1994) Y, Hughson RL. On the fractal nature of heart rate variability in humans: effects of data length and β-adrenergic blockade. Am J Physiol. 1994, 266(1 Pt 2): R40~49
41 Yambe(1995) T, Nitta S, Sonobe T. Deterministic chaos in thermodynamics of an artificial heart. ASAIO J. 1995, 41(1): 84~88
42 白净(1995),吴冬生.桡动脉脉搏波的仿真模型.航天医学与医学工程.1995,8(2):94~98
43 陈先农(1984a),罗致诚.中医脉波的“掌弓旁路效应”与“取脉压阻效应”.中国生物医学工程学报.1984.3(2):95~100
44 陈先农(1984b),罗致诚.一种区分中医脉学脉波信息的新方法.中国生物医学工程学报.1984,3(3):170~174
45 陈晓辉(1985).生物阻抗相对检测灵敏度分布法用于检测和区分在体浅表动脉运动和截面变化的实验研究.学位论文.中国协和医科大学、1985:36~37
46 程小明(1998).心肌电活动的变异性与心电图形态微变的逐拍分析[学位论文].中国协和医科大学.1998
47 傅骢远(1994),牛欣.中医脉象今释.北京:华夏出版社.1994:37~41
48 巩欣洲(1995),王珏,王静,等.外周动脉管荆信号及血流信号在临床诊断中的应用.生物医学工程杂志.1995,12(1):57~63
49 黄世林(1986),孙明異.中医脉象研究.北京:人民卫生出版社.1986:164~196
50 李希臻(1999),宋丹丹.小循环功能·小循环导电技术理论与临床.哈尔滨:黑龙江人民出版社.1999:85~86
51 柳兆荣(1986).心血管流体力学.上海:复旦大学出版社.1986:204~212
52 柳兆荣(I997).血液动力学原理和方法.上海:复旦大学出版社.1997:197~245
53 乔爱科(2000),伍时桂.动脉中的脉搏波理论.生物医学工程学杂志.1998,17(1):95~100
54 史晓瑞(1999),董明敏,姜泗长,等.豚鼠耳蜗微动脉自律运动的连续观察及分析.中华耳鼻咽喉科杂志.1998,33(5):284~2871 Donoho(1994) DL, Johnstone IM. Deal spatial adaptation by wavelet shrinkage. Biometrika.1994,81: 425~455.
2 Donoho(1995) DL, Johnstone IM, Kerkyacharian G, et al. Wavelet shrinkage: asymptopia. Jour. Roy. Stat. Soc., series B. 1995,57(3-2): 301~369.
3 Donoho(1995) DL. De-Noising by soft-thresholding.IEEE Trans. on IT. 1995, 41(3-3): 613~627.
4 Mallat(1992) S, Zhong S. Wavelet transform maxima and multiscale edges. In Wavelets and Their Applications, Ruskai,M.B, et al,eds. 1992
5 Mallat(1991) S. Zeros-crossing of a wavelet transform. IEEE Trans. on IT. 1991, 37(4): 1019~1033.
6 Sankur(1996) B, Guler EC, Kahya YP, et al. Multiresolution biological transient extraction applied to respiratory crackles. Compu. Biol. Med. 1996,26(1):25~39
7 Rioul(1996), Duhamel P.. Fast algorithm for discrete and continuous wavelet transform. IEEE Trans on IT. 1993:38(2):569~586
8 欧阳婧(1999).生物阻抗信号提取与分析[学位论文].北京:清华大学.1999
9 杨福生(1999).小波变换的工程分析与应用.北京:科学出版社.1999
10 赵松年(1996),熊小芸.子波变换与子波分析.北京:电子工业出版社.1996:134~1401 Barbaro(1991) V, Bartolini P, Fierli M. New algorithm for detection of the ECG fiducial point in the averaging technique. Medical & Biological Engineering & Computing. 1991,29(Mar): 129~135
2 Maehara(1999) K, Kokubun T, Awano N, et al. Detection of abnormal high-frequency components in the QRS complex by the wavelet transform in patients with idiopathic dilated cardiomyopathy. Jpn Circ J. 1999,63(1): 25~32.
3 Mallat(1991) S. Zero-crossings of a wavelet transform. IEEE Trans on IT. 1991, 37(4): 1019~1033
4 Mallat(1992) S, Hwang WL. Singularity detection and processing with wavelet. IEEE Trans on IT. 1992, 38(2): 617~643
5 Meste(1994) O,Rix H,Caminal P, et al. Ventricular late potentials characterization in time-frequency domain by means of a wavelet transform. IEEE Trans BME. 1994,41(7): 625~634
6 Morlet D, Peyrin F, Desseigne P, et al. Wavelet analysis of high-resolution signal-averaged ECGs in postinfarction patients. J Electrocardiol 1993, 26(3): 311~320
7 Pan(1985) J,Tompkins W.J. A real time QRS detection algorithm. IEEE Trans on BME,32:230~236
8 Rioul(1993) O, Duhamel P. Fast algorithm for discrete and continuous wavelet transform. IEEE Trans on IT. 1993:38(2):569~586
9 Sahambi(1997a) JS, Tandon SN, Bhatt RK, ct al. Quantitative analysis of errors due to power-line interference and base- line drift in detection of onsets and offsets in ECG using wavelets. Med Biol Eng Comput. 1997,35(6):747~751
10 Sahambi(1997b) JS, Tandon SN, Bhatt RK. Beat by beat QT interval detection and characterization. Biomcd Sci Instrum. 1997,34:143~146
11 Sankur(1996) B,Guler E.C,Kahya Y.P, et al. Multiresolution biological transient extraction applied to respiratory crackles. Compu. Biol. Med. 1996,26(1):25~39
12 陈章位(1997),路甬祥.信号奇异性检测理论及其应用.振动工程学报.1997,10(2):147~155
13 傅骢远,牛欣.中医脉象近释.北京:华夏出版社.1993:29~35
14 黄世林(1986),孙明巽.中医脉象研究.北京:人民卫生出版社.1986:46~47
15 黄献平(1999),李冰星.BYS—14型心电脉象仪与MX—811型脉象仪的比较.湖南中医学院学报.1999,19(1):66~67
16 黄智礼(1995),郑振声.采用心阻抗血流图对体外反搏的控制研究.中国生物医学工程学报.1995,14(4):292~298
17 Li Cuiwei(1995b), Zheng Chongxun, Tai Changfeng. Detection of ECG characteristic points using wavelet transform. IEEE on BME. 1995a, 42(1): 21~28
18 李翠微(1995a),郑崇勋,袁超伟.ECG信号的小波变换检测方法.中国生物医学工程学报.1995b,14(1):39~66
19 李光林(1998),吕维雪.基于小波变换的心电信号的分析与处理.浙江大学学报(自然科学版).1998,32(1):82~87
20 李海云(1997),郑振声,周少春等.子波分析在反搏波起始点检测中的应用.暨南大学学报(自然科学版).1997,18(增卷):86~88
21 秦前清(1994),杨宗凯.实用小波分析.西安:西安电子科技大学出版社.1994
22 寿小云(1999).中医脉象振动觉临床识别.北京中医药大学学报.1999,22(2):14~16
23 王炳和(1999),王海燕.职利琴.高血压患者脉博信号的采集与频谱分析.声学技术.1999.18(2):135~138
24 武伯歌(1990),俞梦孙.心电信号分析中识别R波的一种算法.北京生物医学工程.1990,9(4):211~213
25 吴效明(1996),韩超,岑人经等.颈动脉波特征提取的小波变换分析方法.医用生物力学.1996,11(2):87~91
26 杨福生(1999).小波变换的工程分析与应用.北京:科学出版社.1999:149~151
27 杨毓英(1997),史习智,陈光冶,等.小波变换用于ECG信号的R波实时探测.上海交通大学学报.1997,31(9):18~21
28 张世枢(1999),洪治平,华有德.中医脉象分类的频谱特征研究.辽宁中医杂志.1999.24(10):439~4401 Barbaro(1991) V, Bartolini P, Fierli M. New algorithm for detection of the ECG fiducial point in the averaging technique. Medical & Biological Engineering & Computing. 1991,29:129~135
2 Ronald(1997) M.Adelson. Frequency Estimation from Few Measurements. Digital Signal Processing, 1997,7:47~54
3 陈奎孚(1997),焦群英.矩形窗频谱的精确校正.动态分析与测试技术.1997,(2):46~51.
4 陈奎孚(1998),焦群英,高小榕.提高FFT谱质量的一种新方法.振动、测试与诊断.1998,18(3):216~220
5 陈奎孚(1999),罗致诚,高小榕.判定真实谱峰位置的一个通用准则.数据采集与处理.1999,14(2):247~249
6 [美]崔锦泰(1995).小波分析导论.程正兴译.西安:西安交通大学出版社.1995:31~32
7 程佩青(1995).数字信号处理教程.北京:清华大学出版社.1995:215~252
8 丁康(1996),谢明.离散频谱三点卷积幅值修正法的误差分析.振动工程学报.1996,9(1):92~98
9 高上凯(1994),徐国富.多普勒血流信号仿真模型的建立及谱估计方法研究.中国生物医学工程学报.1994,13(3):200~211
10 胡广书(1997a).正弦信号抽样中若干基本问题的讨论.清华大学学报(自然科学版).1997,37(1):74~77
11 胡广书(1997b).数字信号处理:理论、算法与实现.北京:清华大学出版社.1997:88~92
12 黄迪山(1994).FFT相位误差分析及实用修正方法.振动工程学报 1994,7(2):183~189
13 黄涛(1988).准周期的信号处理方法及其工程应用:[学位论文].北京:清华大学,1988.
14 李植华(1981).实运算快速付里叶变换.清华大学学报.1981,21(4):45~61.
15 刘进明(1995),应怀樵.FFT谱连续细化分析的傅里叶变换法.振动工程学报,1995,8(2):162~166
16 施学喻(1885.).高等数学教程.北京:清华大学出版社,1985.378~379
17 王飞(1992),姜兴渭,董彩凤.周期性信号测量中的相位误差分析.数据采集与处理.1992.7(3):171~176.
18 吴乃龙(1991),袁素云.最大熵方法.长沙:湖南科学出版社.1991
19 吴祁耀(1994),吴祁宗.包含离散谱线的电生理信号的参数模型谱估计问题.北京生物医学工程.1994,13(2):70~73
20 谢明(1994),丁康..频谱分析的校正方法.振动工程学报.1994,7(2):172~179
21 谢明(1995),丁康.离散频谱分析的一种新校正方法.重庆大学学报.1995,(2):47~541 Cohen(1992), A., Daubechies, I. Feauveau JC. Biorthogonal basis of compactly supported wavelets", Comm. Pure Appli. Math.. 1992,45: 485~560.
2 Daubechies(1988) I. Orthogonal bases of compactly supported wavelets. Comm. pure and appl. m(?). 1988,41:909~996
3 Daubechies(1992) I.Ten lectures on wavelets. CBMS-NSF conference series in applied mathematics. SIAM Ed. 1992
4 Mallat(1989a) S. Multiresolution approximations and wavelet orthonormal bases of L~2(R). Trans. Amer. Math. Soc. 1989,315:69~87
5 Mallat(1989b) S. A theory for multiresolution signal decomposition: the wavelet representation. IEEE on PAMI. 1989,11(7): 674~693.
6 秦前清(1994),杨宗凯.实用小波分析.西安:西安电子科技大学出版社.1994:36~37
7 汪胡桢(1985),徐利治.现代工程数学手册(Ⅰ卷).武汉:华中工学院出版社.1985.325~359
8 徐配霞(1996),孙功宪.小波分析与应用实例.合肥:中国科技大学出版社.1996:39~54
9 杨福生(1990).随机信号分析.北京:高等教育出版社.1990:97~106.
10 杨福生(1999).小波变换的工程分析与应用.北京:科学出版社.1999:62~63.
11 宗孔德(1996).多抽样率信号处理.北京:清华大学出版社.19961 Champney (1987)D. A handbook of Fourier theorem. Cambridge Univ. Press. 1987
2 Flandrin(1989) P. On the spectrum of fractional Brownian motion. IEEE Trans on IT. 1989.35(1):197~199
3 Higuchi(1990) T. Relationship between the fractal dimension and the power law index for time series: a numerical investigation. Physica D. 1990,46:254~264
4 Ramanathan(1991) J, et al. On the wavelet transform of fractional Brownian motion. IEEE Trans IT, 1992,37(4): 1156~1158
5 Tewfik(1992) AH, Kim M. Correlation structure of the discrete wavelet coefficients of fractional Browian motion. IEEE Trans. on IT. 1992,38(2):904~909
6 Wornell(1990) G. A Karhunen-Loeve like expansion for l/f process via wavelet, IEEE Trans IT. 1990,36(4):859~861
7 Wornell(1992) G., etal. Estimation of fractal signal from noisy measurements using wavelet, IEEE Trans SP. 1992,40(4),611~632
8 Wornell(1993) G, Oppenheim AV, Wavelet-based representation for the l/f family of fractal process. Proc. Of the IEEE,1993,81(10): 1428~1450
9 [美]Mandelbort BB.大自然的分形几何学.陈守吉,凌复华译.上海:上海远东出版社.1998.
10 曹汉强(1997),朱光喜,朱耀庭等.一种基于小波变换的FBM图象生成方法.中国图象图形学报.1997,2(12):874~877
11 王桥(1995),胡毓钜.分数布朗运动的小波分析.武汉科技测绘大学学报.1995,20(1):66~70
12 薛东辉(1996),朱耀庭,朱光喜等.分数布朗运动的功率谱分析.华中理工大学学报.1996,24(8):7~9
13 杨福生(1999).小波变换的工程分析与应用.北京:科学出版社.1999:217~247
14 庄奕琪(1999),马中发,杜磊.l/f噪声之谜.世界科技研究与发展.1999,21(4):69~721 Ahlersova(1982) E,Ahlers I,Garlatiova E,et al. Influence of the seasons on the circadian rhythm of blood glucose and tissue glycogen in male Wistar rats. Physiol Bohemoslov. 1982,31(1): 45~55
2 Ahlersova(1984) E,Ahlers I,Milarova R, et al. Circadian oscillations of thyroid hormones,insulin and glucagon in the blood of laboratory rats in the course of the year. Physiol Bohemoslov 1984,33(4): 309~319
3 Al-Ani(1996) M,Forkins AS,Townend JN,et al. Respiratory sinus arrhythmia and central respiratory drive in humans. Clin Sci.1996,90(3):235~241
4 Al-Kubati(1997) MA, Fiser B,Siegelova J. Baroreflex sensitivity during psychological stress. Physiol Res. 1997,46(1): 27~33
5 Ayman(1940) D,Goldshine AD. Blood pressure determinations by patients with essential hypertension: the difference between clinic and home readings before treatment. Am J Med Sci. 1940,200:465~474
6 Akselrod(1981) S,Gordon D,Pernpruner S.et al. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 1981,213(10): 220~222
7 Akselrod(1985) S,Gordon D,Madwed JB,et al. Hemodynamic regulation: investigation by spectral analysis. Am J Physiol. 1985,249:H867~875
8 Babloyantz(1988) A, Destexhe A. Is the normal heart a periodic Oscillator? Biol Cybern. 1988,58:203~211
9 Bassingthwaighte(1995) JB,Raymond GE. Evaluation of the dispersional analysis method for fractal time series. Ann Biomed Eng. 1995,23(4): 491~505
10 Bauer(1996) T, Ewig S,Schafer H,et al. Heart rate variability in patients with sleep-related breathing disorders. Cardiology. 1996,87(6): 492~496
11 Benbow SJ,Pryce DW, Noblett K,et al. Flow motion in peripheral diabetic neuropathy. Clin Sci. 1995,88(2): 191~196
12 Bernardi(1994) L, Leuzzi S,Radaelli A,et al. Low-frequency spontaneous fluctuations of R-R interval and blood pressure in conscious humans: a baroreceptor or central phenomenon? Clin Sci. 1994,87(6): 649~654
13 Bernardi(1997) L; Rossi M; Leuzzi S; et al. Reduction of 0.1 Hz microcirculatory fluctuations as evidence of sympathetic dysfunction in insulin-dependent diabetes.Cardiovasc Res. 1997,34(1): 185~91
14 Bertuglia(1996) S,Colantuoni A, Arnold M,et al. Dynamic coherence analysis of vasomotion and flow motion in skeletal muscle microcirculation. Microvasc Res. 1996,52(3): 235~244
15 Bettermann(1998) H,Van-Leeuwen P. Evidence of phase transitions in heart period dynamics. Biol Cybern. 1998,78(1): 63~70
16 Biachi(1993) AM. Time-variant power spectrum analysis for the detection of transient epsidodes in HRV signal. IEEE Trans BME. 1993,40(2): 136~144
17 Binkley(1993) PF, Haas GJ,Starling RC,et al. Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure. J Am Coll Cardiol. 1993,21(3): 655~661
18 Bittner(1974) R,Beger HG,Kraas E,et al. Oscillation in insulin response to glucose??stimulation.Measurements in the portal vein in man in the postoperative period. Horrn Metab Res. 1974,6(5):423~424
19 Bonnet(1998) MH,Arand DL. Heart rate variability in insomniacs and matched normal sleepers. Psychosom Med. 1998,60(5): 610-615
20 Bowden(1980) CR,Bergman RN.Marsh DJ.et al. Cause of glucose oscillations during glucose infusion: periodic variation in glucose uptake. Am J Physiol. 1980,238(4): E395-407
21 Brauer(1999) K,Hahn M. Nonlinear analysis of blood flux in human vessels. Phys Med Biol 1999,44(7): 1719-1733
22 Brodan(1979) V. Use of the periodogram in the analysis of high frequency basal blood sugar oscillations in healthy subjects. Physiol Bohemoslov. 1979,28(2):175~183
23 Butler(1993) GC.Yamamoto Y,Xing HC. Heart rate variability and fractal dimension during orthostatic challenges. J Appl Physiol. 1993,75(6): 2602-2612
24 Butler( 1994a) GC,Yamamoto Y,Hughson RL. Fractal nature of short-term systolic BP and HR variability during lower body negative pressure. Am J Physiol. 1994,267(1 Pt 2): R26-33
25 Butler(1994b) GC.Yamamoto Y.Hughson RL. Heart rate variability to monitor autonomic nervous system activity during orthostatic stress. J Clin Pharmacol. 1994,34(6): 558-562
26 Butler(1995) GC,Naughton MT.Rahman MA,et al. Continuous positive airway pressure increases heart rate variability in congestive heart failure. J Am Coll Cardiol. 1995,25(3): 672-679
27 Butler(1997) GC.Ando S.Floras JS. Fractal component of variability of heart rate and systolic blood pressure in congestive heart failure. Clin Sci Colch. 1997,92(6): 543-550
28 Carrasco(1998) S,Gonzalez R Jimenez J.et al. Comparison of the heart rate variability parameters obtained from the electrocardiogram and the blood pressure wave. J Med Eng Technol. 1998,22(5): 195-205
29 Casolo(1991) G.Balli E.Fazi A.et al. Twenty-four spectral analysis of heart rate variability in congestive heart failure secondary to coronary artery disease. Am J Cardiol. 1991,67: 1154-1158
30 Cavalcanti(1996) S,Ursino M. Chaotic oscillations in microvessel arterial networks. Ann Biomed Eng. 1996,24(1): 37-47
31 Chan(1997) HL.Lin JL,Du CC.et al. Time-frequency distribution of heart rate variability below 0.05Hz by Wigner-Ville spectrak analysis in congestive heart failure patients. 1997,19(6): 581-587
32 Channon(1997) KM.Hargreaves MR.Gardner M.et al. Noninvasive beat-to-beat arterial blood pressure measurement during VVI and DDD pacing: relationship to symptomatic benefit from DDD pacing. Pacing Clin Electrophysiol. 1997.20(1 Pt 1): 25-33
33 Chon(1997) KH.Kanters JK.Cohen RJ. Detection of "noisy" chaosin a time series. Methods Inf Med. 1997,36(4-5): 294-297
34 Coleman(1980) TG. Arteral baroreflex control of heart rate in the consicous rat. Am J Physiol. 1980.238: H515-520
35 Colantuoni( 1990) A.Bertuglia S.Coppini G,et al. Superposition of arteriolar vasomotion waves and regulation of blood flow in skeletal muscle microcirculation. Adv Exp Med Biol. 1990,277: 549-558
36 Constant(1995) I.Girard A,Le Bidois J,et al. Spectral analysis of systolic blood pressure and heart rate after heart transplantation in children. Clin Sci. 1995,88(1): 95-102
37 Colantuoni( 1994) A.Bertuglia S.Intaglietta M. Microvascular vasomotion: origin of laser Doppler flux motion. Int J Microcirc Clin Exp. 1994,14(3): 151-158
38 Corcoran( 1987) JS.Yudkin JS. Loss of spontaneous variability of fingertip anastomotic blood flow in diabetic autonomic neuropathy. Clin Sci. 1987,72(5): 557-562
39 Cottin(1999) F.Papelier Y.Escourrou P.Effects of exercise load and breathing frequency on heart rate and,blood pressure variability during dynamic exercise. Int J Sports Med. 1999,20(4): 232-238
40 Cross( 1994) SS.Cotton DW. Chaos and antichaos in pathology. Hum Pathol. 1994,25(7): 630-637
41 Davidson(1997) S.Reina N.Shefi O.Spectral analysis of heart rate fluctuations and optimum thermal management for low birth weight infants. Med Biol Eng Comput. 1997,35(6): 619-625
42 DePaola(1993) R.Wang HX.Norwood WI. Fractal structure underlying patterns of premature heart beats. Am J Physiol. 1993,265(5 Pt 2): H1603-1613
43 DiRenzo( 1996) GC.Montani M.Fioriti V. Fractal analysis: a new method for evaluating fetal heart rate variability. J Perinat Med. 1996,24(3): 261-269
44 Dykes(l986) FD,Ahmann PA,Baldzer K.,et al. Breath amplitude modulation of heart rate variability in normal full term neonates. Pediatr Res. 1986,20(4): 301-308
45 Endresen( 1997) LP. Chaos in weakly-coupled pacemaker cells. J Theor Biol. 1997,184(1): 41 -50
46 Fagrell(1985) B. Dynamics of skin microcirculation in humans. J Cardiovasc Pharmacol. 1985.7 S: S53-58
47 Fallen(1988) EL.Kamath MV.Ghista DN.et al. Spectral analysis of heart rate variability following human heart transplantation: Evidence for functional reinnervation. J Auton Nerv Syst. 1988,23: 199-206
48 Fleisher(1996) LA,Frank SM.Sessler DI.et al. Thermoregulation and heart rate variability. Clin Sci. 1996 174??90(2): 97-103
49 Fischer(1996) R,Akay NA. A comparison of analytical methods for the study of fractional Brownian motion. Ann Biomed Eng. 1996,24(4): 537-543
50 Fortrat(1997) JO,Yamamoto Y,Hughson RL. Respiratory influences on non-linear dynamics of heart rate variability in humans. Biol Cybern. 1997,77(1): 1-10
51 Funakoshi(1985) A, Ho LL, Jen KL, et al. Diurnal profile of plasma motilin concentrations during fasting and feeding in man. Gastroenterol Jpn. 1985,20(5):446~456
52 Furlan(1990) R,Guzzetti S.Crivellaro W,et al. Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and R-R variabilities in ambulant subjects. Circulation. 1990,81(2): 537-547
53 Gagliardino(1984) JJ.Hernandez RE,Rebolledo OR. Chronobiological aspects of blood glucose regulation: a new scope for the study of diabetes mellitus. Chronobiologia. 1984,11(4): 357-379
54 Galletly(1996) DC,Williams TB.Robinson BJ. Periodic cardiovascular and ventilatory activity during midazolam sedation. Br J Anaesth. 1996,76(4): 503-507
55 Garfinkel(1997) A,Chen PS,Walter DQ.et al. Quasiperiodicity and chaos in cardiac fibrillation. J Clin Invest. 1997,99(2): 305-314
56 Gerhardt(1999) U,Vorneweg P.Riedasch M,et al. Acute and persistant effects of smoking on the baroreceptor function. J Auton Pharmacol. 1999,19(2): 105-108
57 Goldberger( 1990) AL,Rigney DR,West BJ. Chaos and fractals in human physiology. Scientifc American. 1990,262(Feb): 42-49
58 Goldberger(1992) AL. Fractal Mechanisms in the electrophysiology of heart. IEEE Eng Med Biol. 1992,11(6): 46-52
59 Grasso(1995) R,Rizzi G,Schena F,et al. Arterial baroreceptors are not essential for low frequency oscillation of arterial pressure. J Auton Nerv Syst. 1995,50(3):323~331
60 Griffith(1996) TM.Temporal chaos in the microcirculation. Cardiovasc Res. 1996,31(3): 342-358
61 Groome(1994) LJ.Mooney DM,Bentz LS,et al. Spectral analysis of heart rate variability during quiet sleep in normal human fetuses between 36 and 40 weeks of gestation. Early Hum Dev. 1994,38(1): 1-9.
62 Grueis(1989) F,Nakao M,Yamamato M,et al. An interpretation of 1lf fluctuations in neuronal spike trains during dream sleep. Biol Cybern. 1989,60: 161-169
63 Hagerman( 1996) I.Berglund M,Lorin M,et al. Chaos-related deterministic regulation of heart rate variability in time- and frequency domains: effects of autonomic blockade and exercise. Cardiovasc Res. 1996,31(3): 410-418
64 Haker(2000) E,Egekvist H.Bjerring P. Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects. J Auton Nerv Syst. 2000,79(1): 52-59
65 Hayano(1991) J,Sakakibara Y,Yamada A,et al. Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. Am J Cardiol. 1991,67(2): 199-204
66 Hirsch(1981) JA,Bishop B. Respiratory sinus arrhythmia in humans: How breathing pattern modulates heart rate. Am J Physiol. 1981,241: H620-629
67 Honzikova(1990) N.Penaz J.Fiser B. Individual features of circulatory power spectra in man. Eur J Appl Physiol. 1990,59(6): 430-434.
68 Honzikova( 1992) N.Fiser B,Honzik J. Noninvasive determination of baroreflex sensitivity in man by means of spectral analysis. Physiol Res. 1992,41(1): 31-37
69 Hoshikawa(1997) Y,Yamamoto Y. Effects of Stroop color-word conflict test on the autonomic nervous system responses. Am J Physiol. 1997.272(3 Pt 2): H1113-1121
70 Huikuri(1996) HV.Pikkujamsa SM,Airaksinen KE.et al. Sex-related differences in autonomic modulation of heart rate in middle-aged subjects. Circulation. 1996.94(2): 122-125
71 Hughson( 1994a) RL,Yamamoto Y,McCullough,RE,et al. Sympathetic and parasympathetic indicators of heart rate control at altitude studied by spectral analysis. J Appl Physiol. 1994,77(6): 2537-2542
72 Hughson( 1994b) RL,Yamamoto Y Blaber AP,et al. Effect of 28-day head-down bedrest with countermeasures on heart rate variability during LBNP. Aviat Space Environ Med. 1994,65(4): 293-300
73 Hoyer(1996) D,Schmidt K,Zwiener U,et al. Characterization of complex heart rate dynamics and their pharmacological disorders by non- linear prediction and special data transformations. Cardiovasc Res. 1996,31(3): 434-440
74 Ichimaru(1989) Y.Yanaga T. Frequency characteristics of the heart rate variability produced by Cheyne- Stokes respiration during 24-hr ambulatory electrocardiographic monitoring. Comput Biomed Res. 1989,22(3): 225-233
75 Inoue(1991) K,Miyake S.Kumashiro M,et al. Power spectral analysis of blood pressure variability in traumatic quadriplegic humans. Am J Physiol. 1991,260(3 Pt 2): H842-847
76 lreland(1996) N.Meagher J.SIeigh JW.et al. Heart rate variability in patients recovering from general anaesthesia. Br J Anaesth. 1996,76(5): 657-76277 Iyengar(1996) N,Peng CK,Morin R, et al. Age-related alterationsin the fractal scaling of cardiac interbeat interval dynamics. Am J Physiol. 1996,271(4 Pt 2): R1078~1084
78 Jahnukainen(1993) T, van Ravenswaaij-Arts C,Jalonen J Valimaki I. Dynamics of vasomotor thermoregulation of the skin in term and preterm neonates. Early Hum Dev. 1993,33(2): 133~143
79 Jahnukainen(1994) T, Lindqvist A, Vuorinen M,et al. effects in reactivity of forehead and mid-femoral skin blood flow and heart rate in neonates. Early Hum Dev 1994 Nov 18;39(3): 189~200
80 Jahnukainen(1995) T, Lindqvist A, Jalonen J,et al. Skin blood flow oscillations respond more effectively to rhythmic thermal stimulation than to continuous or periodic breathing in newborn infants. Early Hum Dev. 1995,42(3): 195~207
81 Jahnukainen(1996) T, Lindqvist A, Jalonen J,et al. Reactivity of skin blood flow and heart rate to thermal stimulation in infants during the first postnatal days and after a two-month follow-up. Acta Paediatr. 1996,85(6): 733~738
82 Jahnukainen(1999) T, Lindqvist A, Jalonen J;Responsiveness of cutaneous vasculature to thermal stimulation during phototherapy in neonatal jaundice. Eur J Pediatr. 1999,158(9): 757~760
83 Jartti(1996) TT, Tahvanalnen KU,Kaila TJ,et al. Cardiovascular autonomic regulation in asthmatic children evidenced by spectral analysis of heart rate and blood pressure variability. Scand J Clin Lab Invest. 1996,56(6): 545~554
84 Jartti(1997a) TT, Kaila TJ,Tahvanainen KU,et al. Altered cardiovascular autonomic regulation after 2-week inhaled salbutamol treatment in asthmatic children. Eur J Pediatr. 1997,156(11): 883~888
85 Jartti(1997b) TT, Kaila TJ,Tahvanainen K,et al.The acute effects of inhaled salbutamoi on the beat-to-beat variability of heart rate and blood pressure assessed by spectral analysis. Br J Clin Pharmacol. 1997,43(4): 421~428
86 Kanters(1994) JK, Holstein-Rathlou NH,Agner E. Lack of evidence for low-dimensional chaos in heart rate variability. J Cardiovasc Electrophysiol. 1994,5(7): 591~601
87 Kardos(1995) A, Rudas L,Gingl Z,et al. The mechanism of blood pressure variability. Study in patients with fixed ventrieular pacemaker rhythm. Eur Heart J. 1995,16(4): 545~552
88 Kardos(1996) A, Halmai L,Rudas L,et al. Changes in blood pressure and heart period variability in patients with recent acute myocardial infarction. Clin Sci. 1996,91(S): 52~55
89 Kastrup(1989) J,Bulow J,Lassen NA. Vasomotion in human skin before and after local heating recorded with laser Doppler flowmetry. A method for induction of vasomotion. Int J Microcirc Clin Exp. 1989,8(2): 205~215
90 Keselbrener(1996) L,Akselrod S. Selective discrete Fourier transform for time-frequency analysis: method and application on simulated and cardiovascular signals. IEEE on BME. 1996,43(8): 789~802
91 Keyl(1996) C,Lemberger P, Rodig G,et al. Changes in cardiac autonomic control during noctumal repetitive oxygen desaturation episodes in patients with coronary, artery disease. J Cardiovasc Risk. 1996,3(2): 221~227
92 Khadra(1997) LM,Maayah TJ,Dickhaus H. Detecting chaos in HRVsignals in human cardiac transplant recipients. Comput Biomed Res. 1997,30(3): 188~199
93 Kiani(1994) MF, Pries AR, Hsu LL, et al. Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms. Am J Physiol. 1994,266(5 Pt 2): H1822~1828
94 Kim(1997) YH,Garfinkel A, Ikeda T, et al. Spatiotemporal complexity of ventricular fibrillation evealed by tissue mass reduction in isolated swine rightventricle. Further evidence for the quasiperiodic routeto chaos hypothesis. J Clin Invest. 1997, 100(10): 2486~2550
95 Kinugasa(1999) H,Hirayanagi K: Effects of skin surface cooling and heating on autonomic nervous activity and baroreflex sensitivity in humans. Exp Physiol 1999,84(2): 369~377
96 Kobayashi(1982) M,Musha T. l/f Fluctuation of heart beat period. IEEE Trans Biomed Eng. 1982,29((?). 456~457
97 Koerker(1978) DJ,Goodner CJ,Hansen BW,et al. Synchronous,sustained oscillation of C-peptide and insulin in the plasma of fasting monkeys. Endocrinology. 1978,102(5): 1649~1652
98 Kontopoulos(1997) AG, Athyros VG, Papageorgiou AA, et al. Effect of angiotensin-converting enzyme inhibitors on the power spectrum of heart rate variability in post-myocardial infarction patients. Coron Artery Dis. 1997,8(8-9): 517~524
99 Kvernmo(1998) HD, Stefanovska A, Bracic M,et al. Spectral analysis of the laser Doppler perfusion signal in human skin before and after exercise. Microvasc Res. 1998,56(3): 173~182
100 Kvernmo(1999) HD, Stefanovska A, Kirkeboen KA, et al. Oscillations in the human cutaneous blood perfusion signal modified by endothelium-dependent and endothelium-independent vasodilators. Microvasc Res. 1999,57(3): 298~309
101 Lacroix(1992) D,Logier R, Kacet S,et al. Effects of consecutive administration of central and peripheral anticholinergic agents on respiratory sinus arrhythmia in normal subjects. J Auton Nerv Syst. 1992,39(3): 176??211-217
102 Lang(1981) DA,Matthews DR,Burnett M,et al. Brief ,irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes 1981,30(5): 435-439
103 Larsen(1997) PD.Harty M.Thiruchelvam M,et al. Spectral analysis of AC and DC components of the pulse photoplethysmograph at rest and during induction of anaesthesia. Int J Clin Monit Comput. 1997,14(2): 89-95
104 La Rovere(1993) MT.Mortara A,Bigger JT Jr.et al. Reliability of non-invasive measurement of baroreflex sensitivity after myocardial infarction. ATRAMI.an international multicenter prospective study. Eur Heart J. 1993,14(S): 253. Abstract.
105 Laitinen(1999) T, Vauhkonen IK, Niskanen LK, et al. Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects. Diabetes. 1999,48(6): 1295-1296
106 Letienne( 1998) R,Julien C.Zhang ZQ,et al.Characterization of a major slow oscillation in the mesenteric circulation of conscious rats. Clin Exp Pharmacol Physiol. 1998,25(10): 820-824
107 Lindqvist(1983) A,Oja R,Hellman O,et al. Impact of thermal vasomotor control on the heart rate variability of newborn infants. Early Hum Dev. 1983 ,8(1): 37-47.
108 Lindqvist(1989) A,Parviainen P,Kolari P,et al. A non-invasive method for testing neural circulatory control in man. Cardiovasc Res. 1989,23(3): 262-272
109 Lindqvist( 1990a) A,JaIonen J.Parviainen P,et al. Effect of posture on spontaneous and thermally stimulated cardiovascular oscillations. Cardiovasc Res. 1990,24(5): 373-380
110 Lindqvist( 1990b) A. Noninvasive methods to study autonomic nervous control of circulation. Acta Physiol Scand Suppl. 1990,588: 1-107
111 Lindqvist(1991) A,Parviainen P.Jalonen J,et al. Clinical testing of thermally stimulated cardiovascular oscillations in man. Cardiovasc Res. 1991,25(8): 666-675
112 Lindsley(1999) G.Dowse HB,Burgoon PW,et al. A persistent circhoral ultradian rhythm is identified in human core temperature. Chronobiol Int. 1999,16(1): 69-78
113 Lombardi(1996) F,Sandrone G,Mortara A,et al. Linear and nonlinear dynamics of heart rate variability after acute myocardial infarction with normal and reduced left ventricular ejection fraction. Am J Cardiol. 1996,77(15): 1283-1288
114 Lossius(1994) K.Erisksen M.Walloe L. Thermoregulatory fluctuations in heart rate and blood pressure in huamans:effect of cooling and parasympathetic blockade. J Auto Nerv Syst. 1994,47(3):245~254
115 Lossius(1995) K,Eriksen M. Spontaneous flow waves detected by laser Doppler in human skin.Microvasc Res 1995 Jul;50(l):94-I04
116 Lucini(1994) D,Pagani M,Mela GS,et al. Sympathetic restraint of baroreflex control of heart period in normmotensive and hypertensive subjects. Clin Sci. 1994,86(5):547~556
117 Makikallio(1998) TH,Ristimae T,Airaksinen,KE,et al. Heart rate dynamics in patients with stable angina pectoris and utility of fractal and complexity measures. Am J Cardiol. 1998,81(1): 27-31
118 Malliani(1991) A,Pagani M.Lombardi F,et al. Cardiovascular neural regulation explored in the frequency domain. Circulation. 1991,84(2): 482-492
119 Mannix(1997) PA,Inwald DP,Hathorn MK,et al. Thermal entrainment of heart rate in the preterm infant. Pediatr Res. 1997,42(3): 282-286
120 Mazerolles(1996) M,Senard JM.Verwaerde P,et al. Effects of pentobarbital and etomidate on plasma atecholamine levels and spectral analysis of blood pressure and heart rate in dogs. Fundam Clin Pharmacol. 1996,10(3): 298-303
121 Mayhew(1996) JE,Askew S,Zheng Y.Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity. Neuroimage. 1996,4(3 Pt 1): 183-193
122 Mayhew(1998) JE, Hu D, Zheng Y, et al. An evaluation of linear model analysis techniques for processing images of microcirculation activity.Neuroimage. 1998,7(1): 49-71
123 Meyer(1988) JU.Borgstrom P, Lindbom L,et al. Vasomotion patterns in skeletal muscle arterioles during changes in arterial pressure. Microvasc Res. 1988,35(2): 193-203
124 Meyer(1996) M,Marconi C.Ferretti G,et al. Heart rate variability in the human transplanted heart: nonlinear dynamics and Q-T vs R-R-Q-T alterations during exercise suggest a return of neurocardiac regulation in long term recovery. Integr Physiol Behav Sci. 1996,31(4): 289-305
125 Mestivier(1997) D,Chau NP ,Chanudet X.et al. Relationship between diabetic autonomic dysfunction and HRV assessed by recurrence plot. Am J Physiol. 1997,272(3 Pt 2): H1094-1099
126 Modarreszadeh(1990) M,Bruce EN.Gothe B. Nonrandom variability in respiratory cycle parameters of humans during stage 2 sleep. J Appl Physiol. 1990,69(2): 630-639
127 Mohler(1988) FS.Heath JE. Oscillating heat flow from rabbit's pinna. Am J Physiol. 1988,255(3 Pt 2): R464-469128 Montano(1998) N,Cogliati C,Porta A, et al. Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. Circulation. 1998,98(14): 1394-1399
129 Morita-Tsuzuki(1992) Y, Bouskela E, Hardebo JE. Vasomotion in the rat cerebral microcirculation recorded by laser-Doppler flowmetry.Acta Physioi Scand. 1992,146(4):431~439
130 Mortara(1999) A, Sleight P, Pinna GD,et al. Association between hemodynamic impairment and Cheyne-Stokes respiration and periodic breathing in chronic stable congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 1999,84(8): 900~904
131 Mrowka(1996) R,Patzak A,E, Schubert L,et al. Linear and non-linear properties of heart rate in Postnatal maturation. Cardiovasc Res. 1996,31(3): 447~454
132 Mortara(1997) A, Sleight P, Pinna GD,et al. Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability. Circulation. 1997,96(1): 246~252
133 Mulder(1991) LJ,Veldman JB,Ruddel H,et al. On the usefulness of finger blood-pressure measurements for studies on mental workload. Homeost Health Dis. 1991,33(1-2): 47~60
134 Muller(1996) C,Dambacher M,Roskamm H,et al. Pharmacological effects of antianginal drugs on heart rate variability (HRV) and blood pressure variability (BPV) in patients with coronary artery disease (CAD). Clin Sci. 1996,91(S): 52~55
135 Muscelli(1998) E, Emdin M, Natali A, et al. Autonomic and hemodynamic responses to insulin in lean and obese humans. J Clin Endocrinol Metab. 1998, 83(6): 2084~2090
136 Nakamura(1993) Y, Yamamoto Y, Muraoka I. Autonomic control ofheart rate during physical exercise and fractal dimension of heart rate variability. J Appl Physiol. 1993,74(2): 875~881
137 Nitzan(1994) M,de Boer H,Turivnenko S,et al. Power spectrum analysis of spontaneous fluctuations in the photoplethysmographic signal. J Basic Clin Physiol Pharmacol. 1994,5(3-4): 269~276
138 Nitzan(1998) M,Babchenko A, Khanokh B,et al. The variability of the photoplethysmographic signal—a potential method for the evaluation of the autonomic nervous system. Physiol Meas. 1998,19(1): 93~102
139 Noda(1998) A,Yasuma F, Okada T, et al. Circadian rhythm of autonomic activity in patients with obstructive sleep apnea syndrome. Clin Cardiol. 1998,21(4): 271~276
140 Osborne(1989) AR,Provenzale A. Finite correlation dimension for stochastic system with powei-law spectra. Physica D. 1989,35:357~381
141 Omboni(1993) S,Parati G,Frattola A,et al. Spectral and sequence analysis of finger blood pressure variability. Comparison with analysis of intra-arterial recordings. Hypertension. 1993,22(1): 26~33
142 Omboni(1996) S,Parati G,Di Rienzo M,et al. Blood pressure and heart rate variability in autonomic disorders: a critical review. Clin Auton Res. 1996,6(3): 171~182
143 Omboni(1998) S,Parati G,Castiglioni P, et al. Estimation of blood pressure variability from 24-hour ambulatory finger blood pressure. Hypertension. 1998,32(1): 52~58
144 O'Meara(1993) NM,Sturis J,Blackman JD,et al. Analytical problems in detecting rapid insulin secretory pulses in normal humans. Am J Physiol. 1993,264(2 Pt 1):E231~238
145 Ori(1992) Z,Monir G,Weiss J,et al. Heart rate variability. Frequency domain analysis. Cardiol Clin. 1992,10(3): 499~537
146 Otsuka(1997a) K,Cornelissen G,Halberg F. Age,gender and fractalscaling in heart rate variability. Clin Sci Colch. 1997,93(4): 299~308
147 Otsuka(1997b) K,Cornelissen G,Halberg F. Circadian rhythmic fractal scaling of heart rate variability in health and coronary artery disease. Clin Cardiol. 1997,20(7): 631~638
148 Pagani(1986) M,Lombardi F. Power Spectrum analysis of heart and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dogs. Circ Res. 1986,59(1): 178~193
149 Pagani(1995) M,Lucini D,Rimoldi,et al. Effects of phyical and mental exercise on heart rate variability.In Malick M,et al: Heart rate variability. Armonk,NY.Futura publishing company, 1995:145~265
150 Paolisso(1999) G; Manzella D; Tagliamonte MR;Effects of different insulin infusion rates on heart rate variability in lean and obese subjects. Metabolism. 1999,48(6): 755-624
151 Papavasiliou(1995) SS,Brue T, Jaquet P, et al. Pattern of prolactin diurnal secretion in normal humans: evidence for nonlinear dynamics. Neuroendocrinology. 1995,62(5): 444~453
152 Pape(1997) G-Le,Giacomini H,Swynghedauw B,et al. A statistic alanalysis of sequences of cardiac interbeat intervals does not support the chaos hypothesis. J Theor Biol. 1997,184(2): 123~131
153 Parati(1989) G,Casadei R,Groppelli A, et al. Comparison of finger and intra-arterial blood pressure monitoring at rest and during laboratory testing. Hypertension. 1989,13(6 Pt 1): 647~655
154 Parthimos(1996) D,Edwards DH,Griffith TM.Comparison of chaotic and sinusoidal vasomotion in the regulation of microvascular flow.Cardiovasc Res. 1996,31(3):388~399
155 Patwardhan(1995) AR, Vallurupalli S,Evans JM. Override of spontaneous respiratory pattern generator reduces cardiovascular parasympathetic influence. J Appl Physiol. 1995,79(3): 1048~1054 178156 Penzel(1995) T. Blood pressure analysis. J Sleep Res. 1995,4(S1): 15-20
157 Peng(1995) CK,Havlin S.Hausdorff JM. Fractal mechanisms and heart rate dynamics. Long- range correlations and their breakdown with disease. J Electrocardiol. 1995,28(S): 59-65
158 Philippe(1998) EG.Hebert JL,Coirault C,et al. A comparison between systolic aortic root pressure and finger blood pressure. Chest. 1998,113(6): 1466-1474
159 Piccirillo( 1998) G.Vetta F,Viola E,et al. Heart rate and blood pressure variability in obese normotensive subjects. Int J Obes Relat Metab Disord. 1998,22(8): 741-750
160 Piepoli(1997) M.Sleight P.Leuzzi S,et al. Origin of respiratory sinus arrhythmia in conscious humans. An important role for arterial carotid baroreceptors. Circulation. 1997,95(7): 1813-1821
161,Pinna(1996) GD.Maestri R,Rovere MT.et al. An oscillation of the respiratory control system accounts for most of the heart period variability of chronic heart failure patients. Clin Sci 1996,91 (S): 89-91
162 Pinna( 1996b) GD,Maestri R,Mortara A. Estimation of arterial blood pressure variability by spectral analysis: comparison between Finapres and invasive measurements. Physiol Meas. 1996,17(3): 147-169
163 Ponikowski(1996) P,Chua T-P,Amadi AA,et al. Detection and significance of a discrete very low frequency rhythm in R-R interval variability in chronic congestive heart failure. Am J Cardiol. 1996,77(15): 1320-1326
164 Ponikowski (1997)P,Chua T-P,Piepoli M,et al. Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation. 1997,96(8): 2586-2594
165 Ponikowski(1999) P.Piepoli M.Chua T-P,et al. The impact of cachexia on cardiorespiratory reflex control in chronic heart failure. Eur Heart J. 1999,20(22): 1667-1675Poon( 1997) CS.Merrill CK. Decrease of cardiac chaos in congestive heart failure. Nature. 1997,389(6650): 492-495
166 Prank(1994) K,Harms H,Dammig M,et al. Is there low-dimensional chaos in pulsatile secretion of parathyroid hormone in normal human subjects? Am J Physiol. 1994,266(4 Pt 1): E653-658
167 Radaelli(1996) A,ValIe F.Falcone C,et al. Determinants of heart rate variability in heart transplanted subjects during physical exercise. Eur Heart J. 1996,17(3): 462-471
168 Radaelli(1999) A,Perlangeli S,Cerutti MC.et al. Altered blood pressure variability in patients with congestive heart failure. J Hypertens. 1999,17(12): 1153-1161
169 Rapp(1989) PE,Bashore TR,Martinerie JM,etal. Dynamics of brain electrical activity. Brain topogr. 1989,2(1-2): 99-118
170 Rizzoni(1992) D.Muiesan ML.Montani G,et al. Relationship between initial cardiovascular structural changes and daytime and nighttime blood pressure monitoring. Am J Hypertens. 1992,5(3): 180-186
171 Rizzoni(1995) D,Castellano M,Porteri E,et al. Arterial spontaneous rhythmic contractile activity in humans and rats: spectral analysis and regulatory mechanisms. J Hypertens. 1995.13(9): 1043-1052
172 Robinson(1997) TG.James M.Youde J,et al. Cardiac baroreceptor sensitivity is impaired after acute stroke. Stroke. 1997,28(9): 1671-1676
173 Rossberg(1992) F.Penaz J. Heart rate and arterial pressure variability in humans during different orthostatic load. Physiol Res. 1992,41(1): 19-23
174 Ryan(1994) SM.Goldberger AL.Pincus SM. Gender- and age-related differences in heart rate dynamics: are women more complex than men? J Am Coll Cardiol. 1994,24(7): 1700-1707
175 Sapoznikov(1993) D,Luria MH.Gotsman MS. Comparison of different methodologies of heart rate variability analysis. Comput Methods Programs Biomed. 1993,41(2): 69-75
176 Sastre(1998) A.,Cook MR.,Graham C. Nocturnal exposure to intermittent 60 Hz magnetic fields. Bioelectromagnetics 1998,19(2): 98-106
177 Saul(1977) JP. Analysis of long term heart rate variability: Methods, 1/f scaling and implications. Silver springs,Md. IEEEComputer Society Press. 1977: 49-54
178 Schiavi(2000) R,Robertson D,Malliani A,et al. Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus. Circulation. 2000,101(8): 886-892
179 Schuppert(1994) F,Diegelmann B.Geest T. Loss of variability in Graves' disease: stimulatory TSH-receptor antibodies bind to the TSH-receptor in a continued,non-pulsatile and non-chaotic fashion. Chronobiologia. 1994,21(1-2): 21-32
180 Sehested(1998) J,Heringlake M.Schmidt V.Neurohumoral cardiovascular responses to alcohol and their modulation by peroral fluid. Am J Cardiol. 1998,81(6): 761-765
181 Shannahoff-Khalsa(1997) DS.Kennedy B.Yates FE,et al. Low-frequency ultradian insulin rhythms are coupled to cardiovascular,autonomic,and neuroendocrine rhythms. Am J Physiol. 1997,272(3 Pt 2): R962-968
182 Shefi(1998) O,Davidson S,Maayan A,et al. The effect of thermal stimulation on the heart-rate variability in neonates. Early Hum Dev. 1998,52(1): 49-66
183 Shin(1997) K,Minamitani H,Onishi S,et al. Autonomic differences between athletes and nonathletes:??spectral analysis approach. Med Sci Sports Exerc. 1997,29(11): 1482-1490
184 Shiomi(1996) T Guilleminault C Sasanabe R,et al. Augmented very low frequency component of heart rate variability during obstructive sleep apnea. Sleep. 1996,19(5): 370-377
185 Signorini(1994) MG.Cerutti S.Guzzetti S,et al. Non-linear dynamics of cardiovascular variability signals. Methods Inf Med. 1994,33(1): 81-84
186 Simon C(1998). Ultradian pulsatility of plasma glucose and insulin secretion rate: circadian and sleep modulation. Horm Res. 1998,49(3-4): 185-190
187 Sipinkova(1997) I.Hahn G.Meyer M,et al. Effect of respiration and posture on heart rate variability. Physiol Res 1997,46(3): 173-179
188 Skinner(1996) JE.Wolf SG,Kresh JY.et al. Application of chaos theory to a model biological system: evidence of self-organization in the intrinsic cardiac nervous system. Integr Physiol Behav Sci. 1996,31(2): 122-146
189 Slovut(1999) DP.Wenstrom JC.Moeckel RB,et al. Beat-to-beat modulation of heart rate is coupled to coronary perfusion,pressure in the isolated heart. J Appl Physiol. 1999,86(2): 694-700
190 Symth(1969) HS, Sleight P, Pickering GW. Reflex regualtion of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity. Circ Res. 1969,24:109—121
191 Sonnenberg(1994) GE, Hoffman RG, Mueller RA, et al. Splanchnic insulin dynamics and secretion pulsatilities in abdominal obesity. Diabetes. 1994,43(3): 468-477
192 Stansberry(1996) KB.Shapiro SA.Hill MA,et al. Impaired peripheral vasomotion in diabetes. Diabetes Care. 1996,19(7): 715-721
193 Stauss(1998) HM,Anderson EA,Haynes WG,et al. Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol. 1998,274(4 Pt 2): H1277-1283
194 Stucker(1998) M,Steinbrugge J Ihrig C,et al. Rhythmical variations of haemoglobin oxygenation in cutaneous capillaries.Acta Derm Venereol. 1998,78(6): 408~411
195 Sturis J(I991a),Van Cauter E,BIackman JD.et al. Entrainment of pulsatile insulin secretion by oscillatory glucose infusion. J Clin Invest. 1991,87(2): 439-445
196 Sturis J(1991b),Polonsky KS.Mosekilde E,et al. Computer model for mechanisms underlying ultradian oscillations of insulin and glucose. Am J Physiol. 1991,260(5 Pt 1): E801-809
197 Sugihara( 1996) G.Allan W,Sobel D,et al. Nonlinear control of heart rate variability in human infants. Proc Natl Acad Sci U.S.A. 1996,93(6): 2608-2613
198 Takahashi(2000) T,Okada A,Saitoh T,et al. Difference in human cardiovascular response between upright and supine recovery from upright cycle exercise. Eur J Appl Physiol. 2000,81(3): 233-239
199 Takei(1992) Y. Relationship between power spectral densities of PP and R-R intervals. Ann Physiol Anthropol. 1992,11(3): 325-332
200 Tallarida(1994) RJ.Freeman KA. Chaos and control in mass action binding of endogenous compounds. Ann BiomedEng. 1994,22(2): 153-161
201 Takahashi(2000) T.Okada A,Saitoh T,et al. Difference in human cardiovascular response between upright and supine recovery from upright cycle exercise. Eur J Appl Physiol. 2000,81(3): 233-239
202 Thames(1970) MD,Kontos HA. Mechanisms of baroreceptor-induced changes in heart rate. Am J Physiol. 1970,218:251-256
203 Thayer(1997) JF.Nabors-Oberg R.Sollers JJ. Thermoregulation and cardiac variability: a time-frequency analysis. Biomed Sci Instrum 1997,34: 252-256
204 Theiler(1992) J.Galdrikian B,Longtin A,et al. Using surrogate data to detect nonlinearity in time series. In: Nonlinear modeling and forecasting SFI studies in the sciences of complexity,edited by Casdali M,et al. CA: Addison-Wesley. 1992.XII: 163-188
205 Thompson(1993) CR,Brown JS,Gee H,et al. Heart rate variability in healthy term newborns: the contribution of respiratory sinus arrhythmia. Early Hum Dev. 1993,31(3): 217-228
206 Turcott(1996) RG.Teich MC. Fractal character of the electrocardiogram: distinguishing heart-failure and normal patients. Ann Biomed Eng. 1996,24(2): 269-293
207 Ursino(1992a) M,Fabbri G.Role of the myogenic mechanism in the genesis of microvascular oscillations (vasomotion): analysis with a mathematical model. Microvasc Res. 1992,43(2): 156-177
208 Ursino(1996) M,Cavalcanti S.Bertuglia S.et al. Theoretical analysis of complex oscillations in multibranched microvascular networks. Microvasc Res. 1996,51(2): 229-249
209 Ursino( 1992b) M,Fabbri G,Belardinelli E.A mathematical analysis of vasomotion in the peripheral vascular bed. Cardioscience. 1992.3(1): 13-25
210 VanDeBorne(1997) P.Mark AL,Montano N,et al. Effects of alcohol on sympathetic activity.hemodynamics and chemoreflex sensitivity. Hypertension. 1997,29(6): 1278-1283
211 Vanninen(1996) E,Tuunainen A.Kansanen M,et al. Cardiac sympathovagal balance during sleep apnea episodes. Clin Physiol. 1996.16(3): 209-216212 Vaughn(1995) BV, Quint SR,Messenheimer JA, et al. Heart period variability in sleep. Electroencephalogr Clin Neurophysiol. 1995,94(3): 155~162
213 Verwaerde(1996) P, Senard JM,Mazerolles M,et al. Spectral analysis of blood pressure and heart rate,catecholamine and neuropeptide Y plasma levels in a new model of neurogenic orthostatic hypotension in dog. Clin Auton Res. 1996,6(2): 75~82
214 Veglio(1999) F, Molino P, Cat Genova G,et al. Impaired baroreflex function and arterial compliance in primary aldosteronism. J Hum Hypertens. 1999,13(1): 29~36
215 Vybiral(1989) T, Bryg RJ,Maddens ME,et al. Effect of passive tilt on sympathetic and parasympathetic components of HRV in normal subjects. Am J Cardiol. 1989,63(15): 1117~1120
216 Wagner(1995) CD,Mrowka R,Nafz B. Complexity and "chaos" in blood pressure after baroreceptor denervation of conscious dogs. Am J Physiol. 1995,269(5 Pt 2): H1760~1766
217 Wagner(1996) CD,Nafz B,Persson PBTI. Chaos in blood pressurecontrol. Cardiovasc Res. 1996,31(3): 380~387
218 Wang(1996) H,Kuo TB,Chan SH,et al. Spectral analysis of arterial pressure variability during induction of propofol anesthesia. Anesth Analg. 1996,82(5):914~919
219 Watanabe(1996) M,Gilmour RF. Strategy for control of complex low-dimensional dynamics in cardiac tissue. J Math Biol. 1996,35(1): 73~87
220 Weise(1989)F, Heydenreich F. Effects of modified respiratory rhythm on heart rate variability during active orthostatic load. Biomed Biochim Acta. 1989,48(8): 549~556
221 Weise(1995) F, London GM,Pannier BM,et al. Effect of hemodialysis on cardiovascular rhythms in endstage renal failure. Kidney Int. 1995,47(5): 1443~1452
222 West(1987) BJ,Golderberg AL. Physology in fractal dimensions. Am Sci. 1987,75: 354~365
223 Weston(1996) PJ,Panerai RB,McCullough A, et al. Assessment of baroreceptor-cardiac reflex sensitivity using time domain analysis in patients with IDDM and the relation to left ventricular mass index. Diabetologia. 1996,39(11): 1385~1391
224 White(1993) WB,Lund JP, Omvik P. Twenty-four-hour blood pressure load as a surrogate end-point in assessing antihypertensive therapy. J Hypertens. 1993,11(S4): 75~80
225 Widmark(1998) C,Olaison J,Reftel B,et al. Spectral analysis of heart rate variability during desflurane and isoflurane anaesthesia in patients undergoing arthroscopy. Acta Anaesthesiol Scand. 1998,42(2): 204-210
226 Xiu(1985) RJ,Intaglietta M.Computer analysis of the microvascular vasomotion. Pflugers Arch. 1985,403(3): 289~295
227 Yamamoto(1991) Y, Hughson RL. Coarse-graining spectral analysis: new method for studying heart rate variability. J Appl Physiol. 1991,71(3): 1143~1150
228 Yamamoto(1993a) Y, Hughson RL. Extracting fractal components from time series. Phyica D. 1993,68: 250~264
229 Yamamoto(1993b) Y, Hughson RL, Sutton JR. Operation Everest Ⅱ: an indication of deterministic chaos in human heart rate variability at simulated extreme altitude. Biol Cybern. 1993,69(3): 205~212
230 Yamamoto(1994) Y, Hughson RL. On the fractal nature of heart rate variability in humans: effects of data length and β-adrenergic blockade. Am J Physiol. 1994,266(1 Pt 2): R40~49
231 Yamamoto(1995a) Y, Fortrat JO,Hughson RL. On the fractal nature of heart rate variability in humans: effects of respiratory sinus arrhythmia. Am J Physiol. 1995,269(2 Pt 2): H480~486
232 Yamamoto(1995b) Y, Nakamura Y, Sato H,et al. On the fractal nature of heart rate variability in humans: effects of vagal blockade. Am J Physiol. 1995,269(4 Pt 2): R830~837
233 Yambe(1995) T,Nitta S,Sonobe T. Deterministic chaos in thermodynamics of an artificial heart. ASAIO J. 1995,41(1): 84~88
234 Yang(1998) MW, Kuo TB,Lin SM,et al. Power spectral analysis of arterial blood pressure after spinal anesthesia. Acta Anaesthesiol Sin. 1998,36(1): 3~10
235 Yasuda(1994) Y, Yoshizawa M,Nishino H. Effect of exercise intensity on the spectral properties of skin blood flow. Jpn J Physiol. 1994,44(5): 533~546
236 Yeragani(1993) VK.Srinivasan K,Vempati S. Fractal dimension of heart rate time series: an effective measure of autonomic function. J Appl Physiol. 1993,75(6): 2429~2438
237 Yeragani(1997) VK,Sobolewski E,Kay JE,et al. Effect of age onlong-term heart rate variability. Cardiovasc Res. 1997,35(1): 35~42
238 Zbilut(1989) JP, Mayer-Kress G,Sobotka PA, et al. Bifurcation and intrinsic and l/f dynamics in an isolated perfused rat heart. Biol Cybern. 1989,61:371~378
239 Zwiener(1996) U,Hoyer D,Luthke B. Relations between parameters of spectral power densities and deterministic chaos of heart-rate variability. J Auton Nerv Syst. 1996,57(3): 132~135
240 陈芳(1998),顾凡及,徐京华等.一种新的人脑信息传输复杂性的研究.生物物理学报.1998,14(3):??508~512
241 陈晓辉(1985).生物阻抗相对检测灵敏度分布法用于检测和区分在体浅表动脉运动和截面变化的实验研究.学位论文.中国协和医科大学.1985:36-37
242 杜凤和(1999),徐秀英.原发性高血压病人血压昼夜节律变化与心率变异的相关分析.首都医科大学学报.1999,20(1):32~34
243 范中杰(1998),吴宁.急性心肌梗塞患者的压力反射敏感性测定.中华心血管病杂志.1998,26(1):51~54
244 冯伟捷(1997),张剑峰.42例急性心肌梗塞患者24h动态血压的变化.首都医科大学学报.1997,19(4):335~338
245 傅骢远(1994),牛欣.中医脉象今释.北京:华夏出版社.1994:37~41
246 高建新(1996),宋刚.内分泌.见:范少光等,人体生理学.北京:北京医科大学/中国协和医科大学.1996:275
247 韩峰(1988).浅表动脉血压波形、动脉张力动态区分检测的实用化研究.中国协和医科大学.1988
248 何绍雄,宋开源,苏兆虞.时间药理学与时间治疗学.天津:天津科学技术出版社.1994.
249 李澈(1999).心肌兴奋的发生和传播.见苏静怡等:心脏从基础到临床.北京:北京医科大学/中国协和医科大学出版社.1999:154~197
250 李云霞(1994),姚泰.血液循环.见张镜如:生理学(四版).北京:人民卫生出版社.1994:132
251 廖旺才(1995a).心率变异性非线性动力学分析及其应用:[学位论文].北京:清华大学,1995.
252 廖旺才(1995b),杨福生,胡广树.心率变异性非线性信息处理的现状与展望(综述).国外医学生物医学工程分册.1995,18(6):311~316
253 刘泰槰(2000).心肌细胞电生理学.北京:北京大学出版社.2000.
254 上官新红(1998),张维忠.血压变异性.心血管病学进展.1998,19(1):145~147
255 史晓瑞(1999),董明敏,姜泗长,等.豚鼠耳蜗微动脉自律运动的连续观察及分析.中华耳鼻咽喉科杂志.1998,33(5):284~287
256 宋健有(1999),郜建卫.临床神经心脏病学.郑州:河南医科大学出版社,1999:24~25
257 苏定冯(1991),程勇.血压波动性的神经体液调节.生理科学进展.1991,22:271
258 孙福立(1993),焦艳,王觉民,等.意念对调息作用的影响.北京生物医学工程.1993,12(1):25~28
259 童勤业(1992),祝辰,郑璐旦.心脏细胞的非线性动力学分析.中国生物医学工程学报.1992,11(1):1~8
260 童勤业(1998),孔军,徐京华.脑电复杂性分析的新方法.中国生物医学工程学报.1998.17(3):222~225
261 万朝敏(1994),王正荣.血压的多频率生物节律特性及其受内外因素作用变化的机制探讨.生物医学工程杂志.1994,11(3):185~191
262 王虹艳(1998),马玉荣,赵香莲,等.高血压病左室肥厚患者心率变异及动态血压分析.心功能杂志.1998,10(2):72~73
263 王建宁(1984).张力与压力无损区分检测系统的开发及其试用于寸口桡动脉的可行性初步观察.中国协和医科大学.1984
264 吴国强(1999).吴钰珍,沈霖霖,等.高血压病人压力反射敏感性的受损.上海医科大学学报.1999,26(3):172~175
265 吴杰(1998),张开兹,陆再英.心率变异性.见张开滋等:心电信息学.北京:科学技术文献出版社.1998:159~178
266 修瑞娟(1981).金黄地鼠颊囊微血管管径变化电视连续扫描观察.1981,61(5):270~273
267 修瑞娟(1982).微循环的动物实验方法.中华医学杂志.1982,62(8):493~496
268 修瑞娟(1985a),Intaglietta M.微血管自律运动的研究 Ⅰ:微血管自律运动的连续动态观察及电子计算机分析.中华医学杂志.1985,65(3):129~135
269 修瑞娟(1985b),Zweifach BC.微血管自律运动的研究 Ⅱ骨骼肌的微血管的自律运动.中华医学杂志.1985,65(4):203~207
270 修瑞娟(I997).微循环——微妙的生命泉源.微循环学杂志.1997,7(1):1~3
271 杨洁秋(1991).应用极化阻抗传感器进行生物医学测量的初步研究.中国协和医科大学.1991
272 叶继伦(1999),郑崇勋,黄燕.心率变化对心电信号各波间期的影响分析.生物医学工程学杂志.1999,16(1):50~53
273 余平(1999),沈仲元,柴剑宇.气功调息的心率变异.上海中医药大学学报.1999,13(2):58~55
274 张辉(1998),葛霁光,杨明静,等.心电图中的非线性动力学特征.中国生物医学工程学报.1998,17(3):214~221
275 张坚(1995).大鼠肠系膜微淋巴管自律运动特征的研究.中华医学杂志.1995,75(5):262~265
276 周天禄.(1994).生理机能的时间节律.见:何绍雄等,时间药理学与时间生物治疗学.天津:天津科学技术出版社.1994:48~97