GSTT1基因多态性和吸烟与肺癌遗传易感性关系的研究
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摘要
目的:探讨谷胱甘肽S-转移酶T1基因多态性与肺癌遗传易感性的关系及谷胱甘肽S-转移酶T1基因多态性和吸烟在肺癌易感性中的交互作用。
方法:采用病例对照研究和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对100例肺癌患者和135例健康对照者外周血的GSTT1基因型进行检测。
结果:
1.GSTT1(-)基因型在肺癌组和对照组分别为57%(57/100)和41.5%(56/135),二者间有显著性差异(OR=1.919,95%CI=1.128～3.267,P=0.016)。
2.GSTT1(-)基因型患肺鳞癌的风险显著增加(OR=2.699,95%CI=1.130～6.449,P=0.025)。
3.GSTT1(-)基因型的分布不存在性别上的差异(肺癌组OR=1.285,95%CI=0.578～2.859,P=0.538;对照组OR=1.038,95%CI=0.522～2.066,P=0.915)。
4.携带GSTT1(-)基因型的吸烟者较不吸烟者患肺癌的风险增加3.643倍(95%CI=1.269～10.461,P=0.016)。
5.吸烟者携带GSTT1(-)基因型较携带GSTT1(+)基因型患肺癌的风险增加3.286倍(95%CI=1.410～7.655,P=0.006)。
6.吸烟量≥20包年的人群中携带GSTT1(-)基因型者较携带GSTT1(+)基因型者患肺癌的风险增加7.81倍(95%CI=2.122～28.749,P=0.002)。
7.携带GSTT1(-)基因型并吸烟≥20包年者较携带GSTT1(-)基因型并吸烟＜20包年者患肺癌的风险增加5.517倍(95%CI=1.060～28.716,P=0.042)。
结论:
1.GSTT1(-)基因型在肺癌患者中发生频率增高,能够增加肺癌遗传易感性,但GSTT1(-)基因型的分布不存在性别上的差异。
2.GSTT1(-)基因型可能是肺鳞癌的易感性基因型。
3.吸烟与GSTT1(-)基因型间可能存在交互作用,二者协同增加患肺癌的风险性;吸烟量越大且携带GSTT1(-)基因型者患肺癌的风险越高。
Objective:To investigate the association between the genetic polymorphism of GSTT1 and the susceptibility to lung cancer and the interactions between genetic polymorphisms and smoking on lung cancer susceptibility.
Methods:A case-control study and PCR—RFLP techniques were used to identify GSTT1 genotype in 100 cases of lung cancer and 135 controls.
Results:1.The frequency of GSTT1(-) genotype in lung cancer group and controls was 57%(57/100) and 41.5%(56/135) respectively(OR=1.919,95%CI= 1.128～3.267,P=0.016).2.The individuals carried GSTT1(-) genotype remarkably increased the risk of lung squamous cell carcinoma(OR=2.699, 95%CI=1.130～6.449,P=0.025).3.There were no gender differences of GSTT1 (-) genotype distribution.4.In people with GSTT1(-) genotype,smoking markedly increased the risk for lung cancer(OR=3.643,95%CI=1.269 10.461,P=0.016).5.In smokers,GSTT1(-) genotype significantly increased the risk for lung cancer(OR=3.286,95%CI=1.410～7.655,P=0.006).6.In smokers≥20 packyears,GSTT1(-) genotype remarkably increase the risk of lung cancer(OR=7.81,95%CI=2.122～28.749,P=0.002).7.In people with GSTT1(-) genotype,smokers≥20 packyears remarkably increase the risk of lung cancer(OR=5.517,95%CI=1.060～28.716,P=0.042).
Conclusions:1.The distribution frequency of GSTT1(-) genotype was higher in lung cancer.May increase the genetic susceptibility to lung cancer, There were no gender differences of GSTT1(-) genotype distribution.2. GSTT1(-) genotype was associated with the risk for lung squamous cell carcinoma.3.There may be a synergetic interaction between smoking and GSTT1(-) genotype.4.The more the cigarettes smoke,the higher risk of lung cancer increased in those people who are smokers with GSTT1(-) genotype.
方法:采用病例对照研究和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对100例肺癌患者和135例健康对照者外周血的GSTT1基因型进行检测。
结果:
1.GSTT1(-)基因型在肺癌组和对照组分别为57%(57/100)和41.5%(56/135),二者间有显著性差异(OR=1.919,95%CI=1.128～3.267,P=0.016)。
2.GSTT1(-)基因型患肺鳞癌的风险显著增加(OR=2.699,95%CI=1.130～6.449,P=0.025)。
3.GSTT1(-)基因型的分布不存在性别上的差异(肺癌组OR=1.285,95%CI=0.578～2.859,P=0.538;对照组OR=1.038,95%CI=0.522～2.066,P=0.915)。
4.携带GSTT1(-)基因型的吸烟者较不吸烟者患肺癌的风险增加3.643倍(95%CI=1.269～10.461,P=0.016)。
5.吸烟者携带GSTT1(-)基因型较携带GSTT1(+)基因型患肺癌的风险增加3.286倍(95%CI=1.410～7.655,P=0.006)。
6.吸烟量≥20包年的人群中携带GSTT1(-)基因型者较携带GSTT1(+)基因型者患肺癌的风险增加7.81倍(95%CI=2.122～28.749,P=0.002)。
7.携带GSTT1(-)基因型并吸烟≥20包年者较携带GSTT1(-)基因型并吸烟＜20包年者患肺癌的风险增加5.517倍(95%CI=1.060～28.716,P=0.042)。
结论:
1.GSTT1(-)基因型在肺癌患者中发生频率增高,能够增加肺癌遗传易感性,但GSTT1(-)基因型的分布不存在性别上的差异。
2.GSTT1(-)基因型可能是肺鳞癌的易感性基因型。
3.吸烟与GSTT1(-)基因型间可能存在交互作用,二者协同增加患肺癌的风险性;吸烟量越大且携带GSTT1(-)基因型者患肺癌的风险越高。
Objective:To investigate the association between the genetic polymorphism of GSTT1 and the susceptibility to lung cancer and the interactions between genetic polymorphisms and smoking on lung cancer susceptibility.
Methods:A case-control study and PCR—RFLP techniques were used to identify GSTT1 genotype in 100 cases of lung cancer and 135 controls.
Results:1.The frequency of GSTT1(-) genotype in lung cancer group and controls was 57%(57/100) and 41.5%(56/135) respectively(OR=1.919,95%CI= 1.128～3.267,P=0.016).2.The individuals carried GSTT1(-) genotype remarkably increased the risk of lung squamous cell carcinoma(OR=2.699, 95%CI=1.130～6.449,P=0.025).3.There were no gender differences of GSTT1 (-) genotype distribution.4.In people with GSTT1(-) genotype,smoking markedly increased the risk for lung cancer(OR=3.643,95%CI=1.269 10.461,P=0.016).5.In smokers,GSTT1(-) genotype significantly increased the risk for lung cancer(OR=3.286,95%CI=1.410～7.655,P=0.006).6.In smokers≥20 packyears,GSTT1(-) genotype remarkably increase the risk of lung cancer(OR=7.81,95%CI=2.122～28.749,P=0.002).7.In people with GSTT1(-) genotype,smokers≥20 packyears remarkably increase the risk of lung cancer(OR=5.517,95%CI=1.060～28.716,P=0.042).
Conclusions:1.The distribution frequency of GSTT1(-) genotype was higher in lung cancer.May increase the genetic susceptibility to lung cancer, There were no gender differences of GSTT1(-) genotype distribution.2. GSTT1(-) genotype was associated with the risk for lung squamous cell carcinoma.3.There may be a synergetic interaction between smoking and GSTT1(-) genotype.4.The more the cigarettes smoke,the higher risk of lung cancer increased in those people who are smokers with GSTT1(-) genotype.
引文
[1]Armstrong RN.Structure catalytic mechanism and evolution of theglutathione transferases.Chem Res Toxicol,1997,10:2-18
[2]Hayes JD,Flanagan JU,Jowsey IR.Annu Rev Pharmacol Toxicol 2005:45:51-88
[3]P.J.Sherratt,M.M.Manson,A.M.Thomson,et al.Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1,Biochem.j.1998,335:619-630
[4]Benhamou S,Lee WJ,Alexandrie AK,et al.Meta and pooled analyses of the effects of glutathione S-transferase M1 polymorphism and smoking on lung cancer risk.Carcinogenesis,2002,23(8):1343-1350
[5]曹燕飞,陈汉春,刘新发,等.中国湖南人群GSTM1和GSTT1基因多态性与肺癌易感性关系的研究.生命科学研究,2004,8(2):126-132
[6]张吉凯,胡毅玲,胡巢凤,等.谷胱甘肽硫转移酶M1和T1基因多态性与肺癌易感性关系的研究.中国病理生理杂志,2002,18(4):352-355
[7]Sakagavic J,Kalina J,Stubna J,et al.Genetic polymorphism of glutathione S-transferases M1 and T1 as a risk factor in lung and bladder cancers.Neoplasma,1998,45(5):312-317
[8]Ryberg D,Skang V,Hewer A,et al.Genotypes of glutathione transferase M1 and P1 and their significancefor lung DNA adduct levels andcancer risk.Carcinogensis,1997,18(7):1285-1289
[9]徐振晔,主编.肺癌中西医综合治疗.北京:人民卫生出版社,2002.44.
[10]Frusch N,Bosquee L,louis R.[Lung cancer.Epidemiology and etio-logic factors].Rev Med Liege,2007,62(9):548-53.
[11]李代蓉,周清华.肺癌遗传易感性的研究进展[J].中国肺癌杂志2003,6:158-162
[12]Saarikoski ST,Voho A,Reinikainen M,et al.Combined effect of polymorphic GST genes on individual susceptibility to lung cancer.Int J Cancer,1998,77(4):516-521.
[13]潘尚霞,杨淋清,谷胱甘肽硫转移酶人群基因多态性与相关疾病.中国预防医学杂志,2006,7(4):365-368
[14]Norppa H.Genetic susceptibility,biomarker response,andca-ncer [J].Murat Res,2003,544(2-3):339-348.
[15]Cotton SC,Sharp h,Little J,Brockton N Glutathione S-transferase S-transferase polymorphisms and colorectal cancer:a HuGE review._Am J Epidemiol.2000 Jan 1;151(1):7-32.
[16]Heather HN,John KW,David CC,et al.Ethnic differences in the Prevalence of the homozygous deleted genotype of glutathlone S-transferasetheta.Carcinogensis,1995,16(5):1243-1245
[17]Stacy A.GSTM1,GSTT1 and the risk of squarmous cell carcinoma of the head and neck:A Mine-HuGE Review.Am J Epidemiol,2001,154(2):95-105
[18]邬洪梁,陈迈群,周四保,等.湖南土家族、苗族人群GstM基因多态性研究[J].湖南医学,2001,18(1):17-19
[19]林国芳,马晴雯,查永林,等.上海“本地人”正常人群GSTT1和GSTM1基因型多态性研究.癌变·畸变·突变,2001,13(1):10-12
[20]Saarikoski ST,Voho A,Reinikainen M,Anttila S,Kar jalainen A,Malaveille C,Vainio H,Husgafvel-Pursiainen K,Hirvonen A.Combined effect of" polymorphic GST genes on individual susceptibility to lung cancer.Int J Cancer 1998,77:516-21.
[21]d'Errico A,Malats N,Vineis P.Boffetta P.Review of studies of selected metabolic polymorphisms and cancer.IARC Sci.Publ 1999;323-93.
[22]Lewis S J,Cherry NM,Niven RM,Barber PV,Povey AC.GSTM1,GSTT1 and GSTP1 polymorphisms and lung cancer risk.Cancer Lett 2002,180:165-71
[23]Nazar-Stewart V,Vaughan TL,Stapleton P,Van Loo J,Nicol-Blades B,Eaton DL.A population-based study of glutathione S-transferase M1,T1 and P1 genotypes and risk for lung cancer.Lung Cancer 2003,40:247-5
[24]Sorensen M,Autrup H,Tjφnneland A,Glutathione S-transferase T1 null-genotype is associated with an increased risk of lung cancer.Int J Cancer.2004 Jun 10,110(2):219-24
[25]Kumar M,Agarwal SK,Goel SK.Lung cancer risk in north Indian population:role of genetic polymorphisms and smoking.Mol Cell Biochem.2009 Feb;322(1-2):73-9.
[26]Schneider J,Bernges U,Philipp M,Woitowitz HJ.GSTM1,GSTT1,and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking.Cancer Lett.2004 May 10;208(1):65-74
[27]Valle Nazar-Stewart,Thomas h,Vaughan,et al.A populationbased study of glutatione S-tranferases M1,Tland Plgenotypes and risk for lung cancer.2002,40:247-248.
[28]Jinwei Wang,Yifu Deng,Jinglei Cheng,jianminDing GSTgenetic polymorphisms and lung adenocarcinoma susceptibility in a chinese population,Cancer Letters,2003,201:185-193.
[29]Lee KM,Kang D,Clapper ML,Ingelman-Sundberg M et al.CYP1A1,GSTM1,and GSTT1 polymorphisms,smoking,and lung cancer risk in a pooled analysis among Asian populations.Cancer Epidemiol Biomarkers Prey.2008 May;17(5):1120-6.
[30]姚武,王娜,吴拥军等,GSTM1、GSTT1基因缺失与肺癌易感性的关系.中国公共卫生2006年9月第22卷第9期.
[31]Peto R.Influence of dose and duration of smoking on lung cancer rates.IARC Sci Publ 1986;23-33.
[32]Simonato L,Agudo A,Ahrens W,et al.Lung cancer and cigarette smoking in europe:an update of risk estimates and an assessment of inter-country heterogeneity,int J Cancer,2002,91(6):876-887.
[33]邵常霞,项永兵,张薇,GSTM1、GSTT1基因多态性和吸烟与膀胱癌关系的病例对照研究,肿瘤2006年4月第26卷第4期
[34]SHEN Xiao-bing,PU Yue-pu 1 ZHANGJiao.Influence of GSTM 1 and GSTT1 Genotypes and Smoking,Alcohol Exposure on the Occurrence of Gastric Cancer:Case-control Study from Nanjing,China.J EnvironOccupMed,Aug 2005 Vol.22 No.4
[35]高长明,Takezaki Toshiro,昊建中等谷胱甘肽转硫酶T1、M1基因型和烟酒茶嗜好与食管癌、胃癌.肿瘤防治杂志2002年4月第九卷第二期.
[36]时昭红,陈金霞,邓长生,周燕.散发性大肠腺癌易感性与吸烟GSTT1空白基因型.World Chin J Digestol 2004 August;12(8):1806-1808.
[37]Hou SM,FlatS,Nyberg F.Glutathione S-transferase T1- null genotype interacts synergistically with heavy smoking on lung cancer risk.Envion Mol MUTAGEN,2001,38(1):83-86.
[1]Parkin DM,Bray F,Ferlay J,et al.Global cancer statistics,2002[J].CACancer J Chin,2005,55;74-108
[2]Jemal A,Thomas A,Murray T,et al.Cancer statistics,2002.CA Cancer J Clin,52(1):23-47
[3]Sekido Y,Fong KM,Minna J.Progress in understanding the molecular pathogenesis of human lung cancer.Biochim Biophys Acta,1998,1378(1):F21-F59
[4]Simonato L,Agudo A,Ahrens W,etal.Lung cancer and cigarette smoking in Europe:an update of risk estimates and an assessment of inter-country heterogeneity.Int J Cancer,2001,91(6):876-887
[5]Saarikoski ST,Voho A,Reinikainen M,et al.Combined effect of polymorphic GST genes on individual susceptibility to lung cancer.Int J Cancer,1998,77(4):516-521
[6]Cardoso RM,Daniels DS,Bruns CM,et al.Characterization of the electrophile binding site and sustrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum Proteins,2003,51(1):137-46
[7]JEONG H J,KIM H,SEO IY,etal.Association between glutathione S-transferase M 1 and T1 polymorphisms and increased risk for bladder cahcer in Korean smokers[J].Cancer Lett.2003,202:193-19
[8]Hayes JD,Pulford DJ.The glutathione S-transferase supergene family:regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.Crit Rev Biochem Mol Bioi,1995,30(6):445-600
[9]林辉.谷胱甘肽S-转移酶基因缺失与肿瘤易感性.医学综述,2001,7(4):199-200
[10]William R Pearson,William A,et al.Structure and organization of the human theta-class glutathione S-transferase genes GSTM1- GSTM5 on human chromosome 1P~(13.3).Am J Hum Genet,1993;53:220-223.
[11]Coggan M,Whitbread L,Whittingon A,et al.Structure and organization of the human theta-class glutathione S-transferase and Ddopachrome tautomerase gene complex.BiochemJ,1998,334(pt3):617-623.
[12]Landi S.Mammalian class theta GST and differential susceptibility to carcinogens:a review,MutatRes,2000,463(3):247-283
[13]Heather HN,John KW,David CC,etal,Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.Carcinogensis,1995,16(5):1243-1245.
[14]Stacy A,GSTM1,GSTT1.and the risk of.aquarmous cell carcinoma of the head and neck:A Mine - HuGE Review.Am J Epidemiol,2001,154(2):95-105
[15]Aruda YR.Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu(GSTM1) and theta(GSTM1) among distinct ethic groups from Brazil:relevance to environmental carcinomgenesis.Clic Genet,1998,54(3):210-214.
[16]Nuria M,Anne MCR,Fredrik N,et al.lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism.Cancer Epidemiol Biomark Prev,2000,9(8):827-833
[17]Zhao B,Adeline S,Lee JD,et al.Dietary isothiocyanates,Glutathione S-transferase M1 and T1 polymorphism and lung cancer risk among Chinese women in singapore.Cancer Epidemiol Biolmark Prev,2001,10:1062-1065.
[18]曹多志,万俊香,朱雪梅,等.GSTM1和CYP2E1基因多态对慢性苯中毒易感性的影响[J].劳动医学,2001,18(6):334-337
[19]姜红,王淑兰,罗钢等.儿童系统性红斑狼疮GSTu基因缺失与脂质过氧化及抗氧化水平的研究[J].中国医科大学学报,2001,30(4):279-282
[20]林国芳,谭靖伟,沈建华.上海正常人群中谷胱甘肽s-移酶T1基因纯 合缺损[J].癌变畸变突变,1998,10(6):345-348
[21]陆凤娟,吴玉霞等.GST基因多态性与儿童白血病易感性的关系.环境与职业医学2004年8月第21卷第4期,258-260
[22]Adams CH Werely CJ,Victor et al.Allele frequencies for glutathine S-transferase and N-acetyltransferases 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence Clin Chem Lab Med,2003,41:600-605
[23]Stanulla M,Schrappe M,Brenchlin AM,etal.polymorphisms within glutathione S-tranferases gene(GSTT1、GSTM1、GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia:a case control study Blood,2000,95:1222-1228.
[24]Seidegard J,Pero RW,Markowitz MM,et al.Isoenzyme(s) of glutathione transferase(class mu)as amarker for the susceptibility to lung cancer:a follow up study.Carcinog-enesis,1990,1:33-36
[25]Benhamou S,Lee WJ,Alexandrie AK,et al.Meta and pooled analyses of the effects of glutathione S-transferase M1 polymorphism and smoking on lung cancer.risk.Carcinogenesis,2002,23(8):1343-1350
[26]Sreeja L,Syamala V,Hariharan S,et al.CYP1A1,GSTM1,and GSTT1 polymorphisms,smoking,and lung cancer risk in a pooled analysis among Asian populations.Cancer EpidemiolBiomarkers Prey.2008 May;17(5):1120-6.
[27]Kumar M,Agarwal SK,Goel SK.Lung cancer risk in north Indian population:role of genetic polymorphisms and smoking.Mol Cell Biochem.2009 Feb;322(1-2):73-9
[28]Ruano-ravina A,Figueiras A,Loidi L,et al.GSTM1 and GSTT1polymorphisms,tobacco and risk of lung cancer:a case control study from Galicia Spain.Anticancer Res.2003,23(5b):4333-4337
[29]Ryberg D,Skang V,Hewer A,etal Genotypesof glutathione transferase Mland P1 and their singificance for lung DNA adduct levels and cancer risk.Csrcinogensis,1997,18(7):1285-1289
[30]聂立红,王声涌,胡毅玲.肺癌易感性的分子流行病学研究.中国公共卫生,2002,18(7):791-792
[31]Schneider J,Bernges U,Philipp M,Woitowitz HJ.GSTM1,GSTT1,and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking.Cancer Lett.2004 May 10;208(1):65-74
[32]曹燕飞,汉春,新发国,湖南人群GSTM1和GSTT1基因多态性与肺癌易感性的研究.命科学研究,2004,(2):126-132
[33]张吉凯,毅玲,巢凤,等.谷胱甘肽转硫酶M1和T1基因多态性与肺癌易感性关系的研究.中国病理生理杂志,2002,18(4):352-355
[34]张体艳,吴拥军,王子玲,吴逸明.肺癌患者谷胱甘肽S-转移酶P1因GSTP1-105Val多态性分析,郑州大学学报(医学版),2006,41(3):448-451
[35]Jinwei Wang,Yifu Deng,Jinglei Cheng,jianminDing GSTgenetic polymorphisms and lung adenocarcinoma susceptibility in a chinese population,Cancer Letters,2003,201:185-193
[36]Valle Nazar-Stewart,Thomas L,Vaughan,et al.A population -based studyof glutatione S-tranferases M1,T1and Plgenotypes and risk for lung cancer.2002,40:247-248
[37]Sreeja L,Syamala V,Hariharan S,Syamala VS et al.Glutathione S-transferase M1,T1 and P1 polymorphisms:susceptibility and outcome in lung cancer patients.J Exp Ther Oncol.2008;7(1):73-85
[38]LamTK,Gallicchio L,Lindsley K,Shiels M,,et al.Cruciferous vegetable consumption and lung cancer risk:a systematic review.Cancer Epidemiol Biomarkers Prey.2009 Jan;18(1):184-95
[39]Booton R,Ward T,Heighway J,Ashcroft L,et al.Glutathione -S-transferase P1 isoenzyme polymorphisms,platinum-based chemotherapy,and non-small cell lung cancer.J Thorac Oncol. 2006 Sep;1(7):679-83
[40]Gonlugur U,Pinarbasi H,Gonlugur TE,et al.The association between polymorphisms in glutathione S-transferase(GSTM1and GSTT1) and lung cancer outcome.Cancer Invest.2006 Aug -Sep;24(5):497-501
[41]Sweeney C,Nazar-Stewart V,Stapleton PL,et al.Glutathione S-transferase M1,T1,and P1 polymorphisms and survival among lung cancer patients.Cancer Epidemiol Biomarkers Prey.2003Jun;12(6):527-33.
[42]林俊,张信美,钱羽力等.子宫内膜异位症患者谷胱甘肽S-转移酶M1和TI基因缺失检测.中华妇产科杂志.2002,37:371-372
[43]丁岩,陈志芳,林仁勇等.谷胱甘肽S-转移酶M1和TI基因与子宫内膜异位症发病的关系.中华妇产科杂志.2004,39:101-104
[44]Ertunec D,AbanM,Tok EC,et al.Glutathione-S-transferase P1gene polymorphism and susceptibility to endometriosis.Hum Eeport.2005 Aug;20(8):2157-61.Wpub 20005 May
[45]Sharma A,Sharma JK,Murthy NS,et al.Polymorphisrs at GSTM1 and GSTT1 gene loci and suspcetibility to cervical can cer in Indian population[J],Neoplsma,2004,51(1):12-16
[46]Au ww,Sierra CH,Tyring SK,Acquired and genetic suscepti.bilityto cervical eRD.cer[]].Mut atRes.2003.44(2):361-364
[47]Chen C,Madeleine MM,Weiss NS,et al.Glutathions S-tramferase M1 genotyp and the risk of twanous cilrcinoll i of the cervix:a population-based case-control study[J].Am J Epid emiol 1999,150(6):567-572
[48]Da FA,Rossini A,Mendonca G,et al.CYPIA,GSTM1,and GSTT1polymorphisms and breast cancer risk in Brazilian women [J].CancerLett,181:179-186
[49]Man uela,Gago-Dominguez,J Esteban Castelao,et a.Marine n-3fatty acid intake,glutathione S-transforase polymorphisms and breast cancer risk in post menopausal Chinese women in Singapore[J].Careinogene-sis,2004,25:2143-2147
[50] Saadat.M.Glutathione S-transferase M1 and T1 null genotypes and the risk gastric and colorectalcancer. Cancer Lett. 2001, 169:21-26
[51] 高长明, Takeraki T, Sugimura H,等,CYP2E1 GSTM1 GS1TT1基因型与食管癌关系. 中国肿瘤,2001, 10(6)346-349
[52] Ribeiro Pinto LF,Teixeira Rossini AM, Albano RM,et al. Mechanisms of seophageal cancer development in Brazilians. Mutat Res. 2003,44(2-3) :365-73
[53] Sun CA, Wang LY. hen cJ. et al.Genetic polymorphis-InN of glutathione s-transferase M1 and T1 associated with sus ceptibility tO aflatoxin related hepatocarcin genesis among chronic hepatitis B carriers:a nested case control study in Taiwan. Carcino genesis, 2001, 22(8):1289-1294
[54] M unaka M,Kohshi K,Kawamoto.et al. Genetic polymorphisms of tobacco-and alcohol related metabolizing enzymes and the risk of hepatocellular carcinoma.J Cancer Res Clin oncol.2003, 129(6):355-360
[55] Zhong S, WyllieAH, BarnesD,et ol. Relationship betweenGSTM1 genetic polymorphism and susceptibility to bladder,breast and colon cancer[J]. Carcinogenesis,1993,14 (9) :1821-1824
[56] Inoue H,Kiyoharaa C,Marugame T,et al.Cigarete smoking,CYP1A1MSPI and GSTM1 genotypes,and Colorectaladenomas [J]. Can Cer Res,2000,60(14):3749-3752
[57] Kelada SN,Kardia SL,W alker AH.et al.The glutathione S-transferase-mu and -theta genotypes in the etiology of prostate cancer: genotype-environment interactions with smoking.Cancer Epidemio,Biomarkers Prev 2000,9:1329-1334
[58] Caceres DD Itun-ieta J,Acevedo C et al.Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk: exploring some gene-gene and gene-environment interactions.Eur j Epidemiol 2005:20:79-88
[59] ENGEl I S.TAIOI I E,PFEIFFER R,el al.Pooled analysis and meta-analysis of glutalhione S-transferase M 1 and bladder cancer:a HuGE review[J].AⅢJ Epidemiol,2002,156(2);95-10
[60]MUNGAN NA,ABEN KK.BEEKS E.et al.A germline bomozygote dele tion of the glutathione S-transferase Mul gene predisposesto bladder eaneer[J].Urol Int,2000,64(3):134-138
[61]E93 ROTHMAN N.HAYES R B.ZENSER T V.et al.The glutathione S-transferase M1(GSTM1) null genotype and benzidine-asso ciated bladder cancer,urine mutagenicity,and exfoliated urothelial cell DNA adducts[J].Cancer Epidemiol Biomarkers Prey,1996,5(12):979-983
[62]郑天荣,郑秋红,龚福生等.GSTTI和GSTM1基因缺失多态与胃癌易感性.实用肿瘤杂志2002.17(3):155-157
[63]Kim JW Lee GG,Park YG et al.Combi.ned analysis of germline polymorphisms of P53,GSTTI、GSTM1、CYP1A1,and CYP2E1:rela tion to the incidence rate of cervical carcinoma.Cancer,2000,88(9):2082-2091
[64]Park SK,Yoo KY,Lee SJ,et al.Alcohol consumption,glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk,Pharmacogenetics,2000,10(4):301-309
[65]Cheng L,Sturgis EM,Eicher SA,et al.Glutathione S-transferase polymorphisms and risk of squamous-cell carcinaoma of the head and neck.Int J Cancer,1999,84(3):220-224
[2]Hayes JD,Flanagan JU,Jowsey IR.Annu Rev Pharmacol Toxicol 2005:45:51-88
[3]P.J.Sherratt,M.M.Manson,A.M.Thomson,et al.Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1,Biochem.j.1998,335:619-630
[4]Benhamou S,Lee WJ,Alexandrie AK,et al.Meta and pooled analyses of the effects of glutathione S-transferase M1 polymorphism and smoking on lung cancer risk.Carcinogenesis,2002,23(8):1343-1350
[5]曹燕飞,陈汉春,刘新发,等.中国湖南人群GSTM1和GSTT1基因多态性与肺癌易感性关系的研究.生命科学研究,2004,8(2):126-132
[6]张吉凯,胡毅玲,胡巢凤,等.谷胱甘肽硫转移酶M1和T1基因多态性与肺癌易感性关系的研究.中国病理生理杂志,2002,18(4):352-355
[7]Sakagavic J,Kalina J,Stubna J,et al.Genetic polymorphism of glutathione S-transferases M1 and T1 as a risk factor in lung and bladder cancers.Neoplasma,1998,45(5):312-317
[8]Ryberg D,Skang V,Hewer A,et al.Genotypes of glutathione transferase M1 and P1 and their significancefor lung DNA adduct levels andcancer risk.Carcinogensis,1997,18(7):1285-1289
[9]徐振晔,主编.肺癌中西医综合治疗.北京:人民卫生出版社,2002.44.
[10]Frusch N,Bosquee L,louis R.[Lung cancer.Epidemiology and etio-logic factors].Rev Med Liege,2007,62(9):548-53.
[11]李代蓉,周清华.肺癌遗传易感性的研究进展[J].中国肺癌杂志2003,6:158-162
[12]Saarikoski ST,Voho A,Reinikainen M,et al.Combined effect of polymorphic GST genes on individual susceptibility to lung cancer.Int J Cancer,1998,77(4):516-521.
[13]潘尚霞,杨淋清,谷胱甘肽硫转移酶人群基因多态性与相关疾病.中国预防医学杂志,2006,7(4):365-368
[14]Norppa H.Genetic susceptibility,biomarker response,andca-ncer [J].Murat Res,2003,544(2-3):339-348.
[15]Cotton SC,Sharp h,Little J,Brockton N Glutathione S-transferase S-transferase polymorphisms and colorectal cancer:a HuGE review._Am J Epidemiol.2000 Jan 1;151(1):7-32.
[16]Heather HN,John KW,David CC,et al.Ethnic differences in the Prevalence of the homozygous deleted genotype of glutathlone S-transferasetheta.Carcinogensis,1995,16(5):1243-1245
[17]Stacy A.GSTM1,GSTT1 and the risk of squarmous cell carcinoma of the head and neck:A Mine-HuGE Review.Am J Epidemiol,2001,154(2):95-105
[18]邬洪梁,陈迈群,周四保,等.湖南土家族、苗族人群GstM基因多态性研究[J].湖南医学,2001,18(1):17-19
[19]林国芳,马晴雯,查永林,等.上海“本地人”正常人群GSTT1和GSTM1基因型多态性研究.癌变·畸变·突变,2001,13(1):10-12
[20]Saarikoski ST,Voho A,Reinikainen M,Anttila S,Kar jalainen A,Malaveille C,Vainio H,Husgafvel-Pursiainen K,Hirvonen A.Combined effect of" polymorphic GST genes on individual susceptibility to lung cancer.Int J Cancer 1998,77:516-21.
[21]d'Errico A,Malats N,Vineis P.Boffetta P.Review of studies of selected metabolic polymorphisms and cancer.IARC Sci.Publ 1999;323-93.
[22]Lewis S J,Cherry NM,Niven RM,Barber PV,Povey AC.GSTM1,GSTT1 and GSTP1 polymorphisms and lung cancer risk.Cancer Lett 2002,180:165-71
[23]Nazar-Stewart V,Vaughan TL,Stapleton P,Van Loo J,Nicol-Blades B,Eaton DL.A population-based study of glutathione S-transferase M1,T1 and P1 genotypes and risk for lung cancer.Lung Cancer 2003,40:247-5
[24]Sorensen M,Autrup H,Tjφnneland A,Glutathione S-transferase T1 null-genotype is associated with an increased risk of lung cancer.Int J Cancer.2004 Jun 10,110(2):219-24
[25]Kumar M,Agarwal SK,Goel SK.Lung cancer risk in north Indian population:role of genetic polymorphisms and smoking.Mol Cell Biochem.2009 Feb;322(1-2):73-9.
[26]Schneider J,Bernges U,Philipp M,Woitowitz HJ.GSTM1,GSTT1,and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking.Cancer Lett.2004 May 10;208(1):65-74
[27]Valle Nazar-Stewart,Thomas h,Vaughan,et al.A populationbased study of glutatione S-tranferases M1,Tland Plgenotypes and risk for lung cancer.2002,40:247-248.
[28]Jinwei Wang,Yifu Deng,Jinglei Cheng,jianminDing GSTgenetic polymorphisms and lung adenocarcinoma susceptibility in a chinese population,Cancer Letters,2003,201:185-193.
[29]Lee KM,Kang D,Clapper ML,Ingelman-Sundberg M et al.CYP1A1,GSTM1,and GSTT1 polymorphisms,smoking,and lung cancer risk in a pooled analysis among Asian populations.Cancer Epidemiol Biomarkers Prey.2008 May;17(5):1120-6.
[30]姚武,王娜,吴拥军等,GSTM1、GSTT1基因缺失与肺癌易感性的关系.中国公共卫生2006年9月第22卷第9期.
[31]Peto R.Influence of dose and duration of smoking on lung cancer rates.IARC Sci Publ 1986;23-33.
[32]Simonato L,Agudo A,Ahrens W,et al.Lung cancer and cigarette smoking in europe:an update of risk estimates and an assessment of inter-country heterogeneity,int J Cancer,2002,91(6):876-887.
[33]邵常霞,项永兵,张薇,GSTM1、GSTT1基因多态性和吸烟与膀胱癌关系的病例对照研究,肿瘤2006年4月第26卷第4期
[34]SHEN Xiao-bing,PU Yue-pu 1 ZHANGJiao.Influence of GSTM 1 and GSTT1 Genotypes and Smoking,Alcohol Exposure on the Occurrence of Gastric Cancer:Case-control Study from Nanjing,China.J EnvironOccupMed,Aug 2005 Vol.22 No.4
[35]高长明,Takezaki Toshiro,昊建中等谷胱甘肽转硫酶T1、M1基因型和烟酒茶嗜好与食管癌、胃癌.肿瘤防治杂志2002年4月第九卷第二期.
[36]时昭红,陈金霞,邓长生,周燕.散发性大肠腺癌易感性与吸烟GSTT1空白基因型.World Chin J Digestol 2004 August;12(8):1806-1808.
[37]Hou SM,FlatS,Nyberg F.Glutathione S-transferase T1- null genotype interacts synergistically with heavy smoking on lung cancer risk.Envion Mol MUTAGEN,2001,38(1):83-86.
[1]Parkin DM,Bray F,Ferlay J,et al.Global cancer statistics,2002[J].CACancer J Chin,2005,55;74-108
[2]Jemal A,Thomas A,Murray T,et al.Cancer statistics,2002.CA Cancer J Clin,52(1):23-47
[3]Sekido Y,Fong KM,Minna J.Progress in understanding the molecular pathogenesis of human lung cancer.Biochim Biophys Acta,1998,1378(1):F21-F59
[4]Simonato L,Agudo A,Ahrens W,etal.Lung cancer and cigarette smoking in Europe:an update of risk estimates and an assessment of inter-country heterogeneity.Int J Cancer,2001,91(6):876-887
[5]Saarikoski ST,Voho A,Reinikainen M,et al.Combined effect of polymorphic GST genes on individual susceptibility to lung cancer.Int J Cancer,1998,77(4):516-521
[6]Cardoso RM,Daniels DS,Bruns CM,et al.Characterization of the electrophile binding site and sustrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum Proteins,2003,51(1):137-46
[7]JEONG H J,KIM H,SEO IY,etal.Association between glutathione S-transferase M 1 and T1 polymorphisms and increased risk for bladder cahcer in Korean smokers[J].Cancer Lett.2003,202:193-19
[8]Hayes JD,Pulford DJ.The glutathione S-transferase supergene family:regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.Crit Rev Biochem Mol Bioi,1995,30(6):445-600
[9]林辉.谷胱甘肽S-转移酶基因缺失与肿瘤易感性.医学综述,2001,7(4):199-200
[10]William R Pearson,William A,et al.Structure and organization of the human theta-class glutathione S-transferase genes GSTM1- GSTM5 on human chromosome 1P~(13.3).Am J Hum Genet,1993;53:220-223.
[11]Coggan M,Whitbread L,Whittingon A,et al.Structure and organization of the human theta-class glutathione S-transferase and Ddopachrome tautomerase gene complex.BiochemJ,1998,334(pt3):617-623.
[12]Landi S.Mammalian class theta GST and differential susceptibility to carcinogens:a review,MutatRes,2000,463(3):247-283
[13]Heather HN,John KW,David CC,etal,Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta.Carcinogensis,1995,16(5):1243-1245.
[14]Stacy A,GSTM1,GSTT1.and the risk of.aquarmous cell carcinoma of the head and neck:A Mine - HuGE Review.Am J Epidemiol,2001,154(2):95-105
[15]Aruda YR.Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu(GSTM1) and theta(GSTM1) among distinct ethic groups from Brazil:relevance to environmental carcinomgenesis.Clic Genet,1998,54(3):210-214.
[16]Nuria M,Anne MCR,Fredrik N,et al.lung cancer risk in nonsmokers and GSTM1 and GSTT1 genetic polymorphism.Cancer Epidemiol Biomark Prev,2000,9(8):827-833
[17]Zhao B,Adeline S,Lee JD,et al.Dietary isothiocyanates,Glutathione S-transferase M1 and T1 polymorphism and lung cancer risk among Chinese women in singapore.Cancer Epidemiol Biolmark Prev,2001,10:1062-1065.
[18]曹多志,万俊香,朱雪梅,等.GSTM1和CYP2E1基因多态对慢性苯中毒易感性的影响[J].劳动医学,2001,18(6):334-337
[19]姜红,王淑兰,罗钢等.儿童系统性红斑狼疮GSTu基因缺失与脂质过氧化及抗氧化水平的研究[J].中国医科大学学报,2001,30(4):279-282
[20]林国芳,谭靖伟,沈建华.上海正常人群中谷胱甘肽s-移酶T1基因纯 合缺损[J].癌变畸变突变,1998,10(6):345-348
[21]陆凤娟,吴玉霞等.GST基因多态性与儿童白血病易感性的关系.环境与职业医学2004年8月第21卷第4期,258-260
[22]Adams CH Werely CJ,Victor et al.Allele frequencies for glutathine S-transferase and N-acetyltransferases 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence Clin Chem Lab Med,2003,41:600-605
[23]Stanulla M,Schrappe M,Brenchlin AM,etal.polymorphisms within glutathione S-tranferases gene(GSTT1、GSTM1、GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia:a case control study Blood,2000,95:1222-1228.
[24]Seidegard J,Pero RW,Markowitz MM,et al.Isoenzyme(s) of glutathione transferase(class mu)as amarker for the susceptibility to lung cancer:a follow up study.Carcinog-enesis,1990,1:33-36
[25]Benhamou S,Lee WJ,Alexandrie AK,et al.Meta and pooled analyses of the effects of glutathione S-transferase M1 polymorphism and smoking on lung cancer.risk.Carcinogenesis,2002,23(8):1343-1350
[26]Sreeja L,Syamala V,Hariharan S,et al.CYP1A1,GSTM1,and GSTT1 polymorphisms,smoking,and lung cancer risk in a pooled analysis among Asian populations.Cancer EpidemiolBiomarkers Prey.2008 May;17(5):1120-6.
[27]Kumar M,Agarwal SK,Goel SK.Lung cancer risk in north Indian population:role of genetic polymorphisms and smoking.Mol Cell Biochem.2009 Feb;322(1-2):73-9
[28]Ruano-ravina A,Figueiras A,Loidi L,et al.GSTM1 and GSTT1polymorphisms,tobacco and risk of lung cancer:a case control study from Galicia Spain.Anticancer Res.2003,23(5b):4333-4337
[29]Ryberg D,Skang V,Hewer A,etal Genotypesof glutathione transferase Mland P1 and their singificance for lung DNA adduct levels and cancer risk.Csrcinogensis,1997,18(7):1285-1289
[30]聂立红,王声涌,胡毅玲.肺癌易感性的分子流行病学研究.中国公共卫生,2002,18(7):791-792
[31]Schneider J,Bernges U,Philipp M,Woitowitz HJ.GSTM1,GSTT1,and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking.Cancer Lett.2004 May 10;208(1):65-74
[32]曹燕飞,汉春,新发国,湖南人群GSTM1和GSTT1基因多态性与肺癌易感性的研究.命科学研究,2004,(2):126-132
[33]张吉凯,毅玲,巢凤,等.谷胱甘肽转硫酶M1和T1基因多态性与肺癌易感性关系的研究.中国病理生理杂志,2002,18(4):352-355
[34]张体艳,吴拥军,王子玲,吴逸明.肺癌患者谷胱甘肽S-转移酶P1因GSTP1-105Val多态性分析,郑州大学学报(医学版),2006,41(3):448-451
[35]Jinwei Wang,Yifu Deng,Jinglei Cheng,jianminDing GSTgenetic polymorphisms and lung adenocarcinoma susceptibility in a chinese population,Cancer Letters,2003,201:185-193
[36]Valle Nazar-Stewart,Thomas L,Vaughan,et al.A population -based studyof glutatione S-tranferases M1,T1and Plgenotypes and risk for lung cancer.2002,40:247-248
[37]Sreeja L,Syamala V,Hariharan S,Syamala VS et al.Glutathione S-transferase M1,T1 and P1 polymorphisms:susceptibility and outcome in lung cancer patients.J Exp Ther Oncol.2008;7(1):73-85
[38]LamTK,Gallicchio L,Lindsley K,Shiels M,,et al.Cruciferous vegetable consumption and lung cancer risk:a systematic review.Cancer Epidemiol Biomarkers Prey.2009 Jan;18(1):184-95
[39]Booton R,Ward T,Heighway J,Ashcroft L,et al.Glutathione -S-transferase P1 isoenzyme polymorphisms,platinum-based chemotherapy,and non-small cell lung cancer.J Thorac Oncol. 2006 Sep;1(7):679-83
[40]Gonlugur U,Pinarbasi H,Gonlugur TE,et al.The association between polymorphisms in glutathione S-transferase(GSTM1and GSTT1) and lung cancer outcome.Cancer Invest.2006 Aug -Sep;24(5):497-501
[41]Sweeney C,Nazar-Stewart V,Stapleton PL,et al.Glutathione S-transferase M1,T1,and P1 polymorphisms and survival among lung cancer patients.Cancer Epidemiol Biomarkers Prey.2003Jun;12(6):527-33.
[42]林俊,张信美,钱羽力等.子宫内膜异位症患者谷胱甘肽S-转移酶M1和TI基因缺失检测.中华妇产科杂志.2002,37:371-372
[43]丁岩,陈志芳,林仁勇等.谷胱甘肽S-转移酶M1和TI基因与子宫内膜异位症发病的关系.中华妇产科杂志.2004,39:101-104
[44]Ertunec D,AbanM,Tok EC,et al.Glutathione-S-transferase P1gene polymorphism and susceptibility to endometriosis.Hum Eeport.2005 Aug;20(8):2157-61.Wpub 20005 May
[45]Sharma A,Sharma JK,Murthy NS,et al.Polymorphisrs at GSTM1 and GSTT1 gene loci and suspcetibility to cervical can cer in Indian population[J],Neoplsma,2004,51(1):12-16
[46]Au ww,Sierra CH,Tyring SK,Acquired and genetic suscepti.bilityto cervical eRD.cer[]].Mut atRes.2003.44(2):361-364
[47]Chen C,Madeleine MM,Weiss NS,et al.Glutathions S-tramferase M1 genotyp and the risk of twanous cilrcinoll i of the cervix:a population-based case-control study[J].Am J Epid emiol 1999,150(6):567-572
[48]Da FA,Rossini A,Mendonca G,et al.CYPIA,GSTM1,and GSTT1polymorphisms and breast cancer risk in Brazilian women [J].CancerLett,181:179-186
[49]Man uela,Gago-Dominguez,J Esteban Castelao,et a.Marine n-3fatty acid intake,glutathione S-transforase polymorphisms and breast cancer risk in post menopausal Chinese women in Singapore[J].Careinogene-sis,2004,25:2143-2147
[50] Saadat.M.Glutathione S-transferase M1 and T1 null genotypes and the risk gastric and colorectalcancer. Cancer Lett. 2001, 169:21-26
[51] 高长明, Takeraki T, Sugimura H,等,CYP2E1 GSTM1 GS1TT1基因型与食管癌关系. 中国肿瘤,2001, 10(6)346-349
[52] Ribeiro Pinto LF,Teixeira Rossini AM, Albano RM,et al. Mechanisms of seophageal cancer development in Brazilians. Mutat Res. 2003,44(2-3) :365-73
[53] Sun CA, Wang LY. hen cJ. et al.Genetic polymorphis-InN of glutathione s-transferase M1 and T1 associated with sus ceptibility tO aflatoxin related hepatocarcin genesis among chronic hepatitis B carriers:a nested case control study in Taiwan. Carcino genesis, 2001, 22(8):1289-1294
[54] M unaka M,Kohshi K,Kawamoto.et al. Genetic polymorphisms of tobacco-and alcohol related metabolizing enzymes and the risk of hepatocellular carcinoma.J Cancer Res Clin oncol.2003, 129(6):355-360
[55] Zhong S, WyllieAH, BarnesD,et ol. Relationship betweenGSTM1 genetic polymorphism and susceptibility to bladder,breast and colon cancer[J]. Carcinogenesis,1993,14 (9) :1821-1824
[56] Inoue H,Kiyoharaa C,Marugame T,et al.Cigarete smoking,CYP1A1MSPI and GSTM1 genotypes,and Colorectaladenomas [J]. Can Cer Res,2000,60(14):3749-3752
[57] Kelada SN,Kardia SL,W alker AH.et al.The glutathione S-transferase-mu and -theta genotypes in the etiology of prostate cancer: genotype-environment interactions with smoking.Cancer Epidemio,Biomarkers Prev 2000,9:1329-1334
[58] Caceres DD Itun-ieta J,Acevedo C et al.Relationship among metabolizing genes, smoking and alcohol used as modifier factors on prostate cancer risk: exploring some gene-gene and gene-environment interactions.Eur j Epidemiol 2005:20:79-88
[59] ENGEl I S.TAIOI I E,PFEIFFER R,el al.Pooled analysis and meta-analysis of glutalhione S-transferase M 1 and bladder cancer:a HuGE review[J].AⅢJ Epidemiol,2002,156(2);95-10
[60]MUNGAN NA,ABEN KK.BEEKS E.et al.A germline bomozygote dele tion of the glutathione S-transferase Mul gene predisposesto bladder eaneer[J].Urol Int,2000,64(3):134-138
[61]E93 ROTHMAN N.HAYES R B.ZENSER T V.et al.The glutathione S-transferase M1(GSTM1) null genotype and benzidine-asso ciated bladder cancer,urine mutagenicity,and exfoliated urothelial cell DNA adducts[J].Cancer Epidemiol Biomarkers Prey,1996,5(12):979-983
[62]郑天荣,郑秋红,龚福生等.GSTTI和GSTM1基因缺失多态与胃癌易感性.实用肿瘤杂志2002.17(3):155-157
[63]Kim JW Lee GG,Park YG et al.Combi.ned analysis of germline polymorphisms of P53,GSTTI、GSTM1、CYP1A1,and CYP2E1:rela tion to the incidence rate of cervical carcinoma.Cancer,2000,88(9):2082-2091
[64]Park SK,Yoo KY,Lee SJ,et al.Alcohol consumption,glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk,Pharmacogenetics,2000,10(4):301-309
[65]Cheng L,Sturgis EM,Eicher SA,et al.Glutathione S-transferase polymorphisms and risk of squamous-cell carcinaoma of the head and neck.Int J Cancer,1999,84(3):220-224