功能化磁性纳米颗粒的应用
|
摘要
磁性纳米颗粒由于其自身较大的比表面积、相对较高的饱和磁矩以及表面易功能化等特点,被广泛应用于蛋白质或酶的固定,药物的靶向运输,细胞分离,医学成像等方面。
本论文研究围绕将磁性二氧化硅纳米颗粒,模拟酶以及具有离子识别能力的受体相结合,建立新的分析方法,应用于实际样品的检测。论文共分五章。
第一章为绪论,介绍了不断发展的纳米生物材料,着重介绍了二氧化硅和磁性纳米颗粒的合成及应用,并详细介绍了复合式磁性纳米颗粒在生物学和催化领域中的应用。在此基础上提出了本论文选题依据,研究目标和研究内容。
第二章主要研究了氯化血红素磁性纳米颗粒的制备及其在过氧化氢测定中的应用。本章中首次将四氧化三铁二氧化硅纳米颗粒和模拟酶(氯化血红素)相结合,采用反相胶束法和St(o|¨)ber法相结合的方法,制备出磁性模拟酶复合纳米颗粒(Fe_3O_4-hemin/SiO_2 Nps),并以该纳米颗粒作为催化剂,催化过氧化氢氧化对羟基苯乙酸,生成强荧光物质——联-对羟基苯乙酸,从而建立了灵敏、可靠的检测痕量过氧化氢的荧光分析法。该方法灵敏度高(检测限可达7.3 nmol/L),重现性好,且此模拟酶催化剂可重复多次使用。
第三章报道了将磁性分离的优势和氯化血红素信号放大的功能相结合,建立了磁性模拟酶荧光免疫检测抗原的新方法。首先,由于磁性二氧化硅纳米颗粒较小的体积,可以负载较多的抗体,相当于荧光信号放大一次;其次,氯化血红素作为标记物催化过氧化氢氧化对羟基苯乙酸,又可进一步放大荧光信号,相当于荧光信号放大两次。该方法检测人IgG的检测限可达9.8 ng/mL。与其它免疫检测方法相比,本方法具有相对较低的检测限。将该方法用于血清中人IgG的测定也取得了满意的结果。
第四章初步探讨了3-吡啶-4-氨基-5-巯基-1,2,4-三唑在NH_4OH-NH_4Cl缓冲溶液(pH 11)中的光谱性质及其对金属离子的识别。可望与磁性纳米颗粒相结合,应用于污水中银离子的测定。
第五章对下一步的研究工作提出了设想。
Due to the high surface-to-volume ratio, relatively great saturation magnetization values and easily surface functionalization of the nagnetic nanoparticle, it has been widely used in the immobilization of proteins and enzymes, drug delivery and targeting, cell separation, bioimaging and so on.
This dissertation mainly focused on the design of novel analytic methods, which combining the magnetic silica nanoparticles, mimetic enzyme (hemin) and the receptor molecules. And then, these novel methods can be used in real sample detection. This dissertation consists of five chapters.
In chapter one, the progress and development of nano-biomaterials were introduced. And it briefly summaries how to synthesize and apply the silica nanoparticles and magnetic nanoparticles, especially describes the application of magnetic composite nanoparticles in the biological and catalytic fields. In addition, the bases, objectives and contents for designing this thesis were also presented.
In chapter two, synthesis and application of magnetite-hemin/Silica nanoparticles in the analytical field were reported. In this chapter, a method for coating magnetite and mimetic enzyme with amorphous silica to form a novel magnetic composite catalyst has been developed by combining reverse microemulsion and Sober method. By using the magnetite-hemin/Silica nanoparticles as catalysis, which can catalyze the oxidation reaction of p-hydroxyphenyl acetic acid by hydrogen peroxide, a novel fluorimetric method was proposed for the detection of trace amount of hydrogen peroxide. This method is sensitive and reliable, with a detection limit of 7.3 nmol/L in the determination of hydrogen peroxide.
In chapter three, a magnetic-mimetic enzyme fluorescence immunoassay method for antigen detection has been developed by taking advantage of a magnetic separation process and the amplification feature of hemin label. This method is based on twice amplified fluorescence signal: the signal is firstly amplified due to the ultrasmall size and the high surface-to-volume ratio of the silica-coated magnetite nanoparticles, which enable the nanoparticles to carry much more antibodies. Then mimetic enzyme (hemin) as a labeling reagent which catalyzes the reaction of p-hydroxyphenyl acetic acid and H_2O_2 can further amplify fluorescence signal. The detection limit was 9.8 ng/mL for the determination of human IgG, which is comparable to or better than other immuoassay formats. Besides this, a satisfactory result was acquired by using this proposed method for the analysis of real samples.
Chapter four was about the preliminary investigation of the absorption and fluorescence spectral properties of the synthesized sensor (3-pyridyl-4-amino-5-mercapto-1,2,4-triazole) and its response to metal ions in NH_4OH-NH_4Cl buffer (pH 11). Moreover, it is fully anticipated that this sensor can be combined with magnetic nanoparticles to apply in the detection of silver ion in the wastewater.
In chapter five, the final part of the dissertation, the prospect of this research was discussed.
本论文研究围绕将磁性二氧化硅纳米颗粒,模拟酶以及具有离子识别能力的受体相结合,建立新的分析方法,应用于实际样品的检测。论文共分五章。
第一章为绪论,介绍了不断发展的纳米生物材料,着重介绍了二氧化硅和磁性纳米颗粒的合成及应用,并详细介绍了复合式磁性纳米颗粒在生物学和催化领域中的应用。在此基础上提出了本论文选题依据,研究目标和研究内容。
第二章主要研究了氯化血红素磁性纳米颗粒的制备及其在过氧化氢测定中的应用。本章中首次将四氧化三铁二氧化硅纳米颗粒和模拟酶(氯化血红素)相结合,采用反相胶束法和St(o|¨)ber法相结合的方法,制备出磁性模拟酶复合纳米颗粒(Fe_3O_4-hemin/SiO_2 Nps),并以该纳米颗粒作为催化剂,催化过氧化氢氧化对羟基苯乙酸,生成强荧光物质——联-对羟基苯乙酸,从而建立了灵敏、可靠的检测痕量过氧化氢的荧光分析法。该方法灵敏度高(检测限可达7.3 nmol/L),重现性好,且此模拟酶催化剂可重复多次使用。
第三章报道了将磁性分离的优势和氯化血红素信号放大的功能相结合,建立了磁性模拟酶荧光免疫检测抗原的新方法。首先,由于磁性二氧化硅纳米颗粒较小的体积,可以负载较多的抗体,相当于荧光信号放大一次;其次,氯化血红素作为标记物催化过氧化氢氧化对羟基苯乙酸,又可进一步放大荧光信号,相当于荧光信号放大两次。该方法检测人IgG的检测限可达9.8 ng/mL。与其它免疫检测方法相比,本方法具有相对较低的检测限。将该方法用于血清中人IgG的测定也取得了满意的结果。
第四章初步探讨了3-吡啶-4-氨基-5-巯基-1,2,4-三唑在NH_4OH-NH_4Cl缓冲溶液(pH 11)中的光谱性质及其对金属离子的识别。可望与磁性纳米颗粒相结合,应用于污水中银离子的测定。
第五章对下一步的研究工作提出了设想。
Due to the high surface-to-volume ratio, relatively great saturation magnetization values and easily surface functionalization of the nagnetic nanoparticle, it has been widely used in the immobilization of proteins and enzymes, drug delivery and targeting, cell separation, bioimaging and so on.
This dissertation mainly focused on the design of novel analytic methods, which combining the magnetic silica nanoparticles, mimetic enzyme (hemin) and the receptor molecules. And then, these novel methods can be used in real sample detection. This dissertation consists of five chapters.
In chapter one, the progress and development of nano-biomaterials were introduced. And it briefly summaries how to synthesize and apply the silica nanoparticles and magnetic nanoparticles, especially describes the application of magnetic composite nanoparticles in the biological and catalytic fields. In addition, the bases, objectives and contents for designing this thesis were also presented.
In chapter two, synthesis and application of magnetite-hemin/Silica nanoparticles in the analytical field were reported. In this chapter, a method for coating magnetite and mimetic enzyme with amorphous silica to form a novel magnetic composite catalyst has been developed by combining reverse microemulsion and Sober method. By using the magnetite-hemin/Silica nanoparticles as catalysis, which can catalyze the oxidation reaction of p-hydroxyphenyl acetic acid by hydrogen peroxide, a novel fluorimetric method was proposed for the detection of trace amount of hydrogen peroxide. This method is sensitive and reliable, with a detection limit of 7.3 nmol/L in the determination of hydrogen peroxide.
In chapter three, a magnetic-mimetic enzyme fluorescence immunoassay method for antigen detection has been developed by taking advantage of a magnetic separation process and the amplification feature of hemin label. This method is based on twice amplified fluorescence signal: the signal is firstly amplified due to the ultrasmall size and the high surface-to-volume ratio of the silica-coated magnetite nanoparticles, which enable the nanoparticles to carry much more antibodies. Then mimetic enzyme (hemin) as a labeling reagent which catalyzes the reaction of p-hydroxyphenyl acetic acid and H_2O_2 can further amplify fluorescence signal. The detection limit was 9.8 ng/mL for the determination of human IgG, which is comparable to or better than other immuoassay formats. Besides this, a satisfactory result was acquired by using this proposed method for the analysis of real samples.
Chapter four was about the preliminary investigation of the absorption and fluorescence spectral properties of the synthesized sensor (3-pyridyl-4-amino-5-mercapto-1,2,4-triazole) and its response to metal ions in NH_4OH-NH_4Cl buffer (pH 11). Moreover, it is fully anticipated that this sensor can be combined with magnetic nanoparticles to apply in the detection of silver ion in the wastewater.
In chapter five, the final part of the dissertation, the prospect of this research was discussed.
引文
[1]Christopher R.L.Nanobiotechnology:the fabrication and application of chemical and biological nanostructures[J].Current Opinion in Structural Biology,2000,10(4):428-434.
[2]Laval J.-M.,Chopineau J.,Thomas D.Nanotechnology:R&D challenges and opportunities for application in biotechnology[J].Trends in Biotechnology,1995,13(11):470-480.
[3]Siegel R.W.,Hu E.,Roco M.C.Nanostructure sience and technology:R&D status and trends in nanoparticles,nanostructured materials,and nanodevices[R].1999.
[4]West J.L.,Halas N.J.Applications of nanotechnology to biotechnology[J].Current Opinion in Biotechnology,2000,11(2):215-217.
[5]Barbe C.,Bartlett J.,Kong L.,Finnie K.,Lin H.Q.,Larkin M.,Calleja S.,Bush A.,Calleja G.Silica particles:a novel drug-delivery system[J].Advanced Materials,2004,16(21):1959-1966.
[6]Tan W.,Wang K.,He X.,Zhao X.J.,Drake T.,Wang L.,Bagwe R.P.Bionanotechnology based on silica nanoparticles[J].Medicinal Research Reviews,2004,24(5):621-638.
[7]Stoeber W.,Fink A.,Bohn E.Controlled growth of monodisperse silica spheres in the micron size range[J].Journal of Colloid and Interface Science,1968,26(1):62-69.
[8]Van Helden A.K.,Jansen J.W.,Vrij,A.Preparation and characterization of spherical monodisperse silica dispersions in nonaqucous solvents[J].Journal of Colloid and Interface Science,1981,81(2):354-368.
[9]Tan,C.G.,Bowen B.D.,Epstein N.Production of monodisperse colloidal silica spheres:effect of temperature[J].Journal of Colloid and Interface Science,1987,118(1):290-293.
[10]Nyffenegger R.,Quellet C.,Ricka J.Synthesis of fluorescent,monodisperse,colloidal silica particles[J].Journal of Colloid and Interface Science,1993,159(1):150-157.
[11]Coenen S.,De Kruif C.G.Synthesis and growth of colloidal silica particles[J].Journal of Colloid and Interface Science,1988,124(1):104-110.
[12]Van Blaaderen A.,Imhof A.,Hage W.,Vrij A.Three-dimensional imaging of submicrometer colloidal particles in concentrated suspensions using confocal scanning laser microscopy[J].Langmuir,1992,8(6):1514-1517.
[13]Van Blaaderen A.,Vrij A.Synthesis and characterization of colloidal dispersions of fluorescent,monodisperse silica spheres[J].Langmuir,1992,8(12):2921-2931.
[14]Verhaegh N.A.M.,Van Blaaderen A.Dispersions of rhodamine-labeled silica spheres:synthesis,characterization,and fluorescence confocal scanning laser microscopy[J].Langmuir,1994,10(5):1427-1438.
[15]Imhof A.,Megens M.,Engelberts J.J.,De Lang D.T.N.,Sprik R.,Vos W.L.Spectroscopy of Fluorescein(FITC) dyed colloidal silica spheres[J].Journal of Physical Chemistry B,1999,103(9):1408-1415.
[16]Ow H.,Larson D.R.,Srivastava M.,Baird B.A.,Webb W.W.,Wiesner U.Bright and stable core-shell fluorescent silica nanoparticles[J].Nano Letters,2005,5(1):113-117.
[17]Lindberg R.,Sjoeblom J.,Sundholm G.Preparation of silica particles utilizing the sol-gel and the emulsion-gel processes[J].Colloids and Surfaces,A:Physicochemical and Engineering Aspects,1995,99(1):79-88.
[18]Osseo-Asare K.,Arriagada F.J.Preparation of silica nanoparticles in a non-ionic reverse micellar system[J].Colloids and Surfaces,1990,50:321-339.
[19]Arriagada F.J.,Osseo-Assare K.Synthesis of nanosize silica in aerosol OT reverse microemulsions[J].Journal of Colloid and Interface Science,1995,170(1):8-17.
[20]Zhao X.,Bagwe R.P.,Tan W.,Development of organic-dye-doped silica nanoparticles in a reverse microemulsion[J].Advanced Materials,2004,16(2):173-176.
[21]He X.-X.,Wang K.,Tan W.,Liu B.,Lin X.,He C.,Li D.,Huang S.,Li J.Bioconjugated nanoparticles for DNA protection from cleavage[J].Journal of the American Chemical Society,2003,125(24):7168-7169.
[22]Santra S.,Yang H.,Dutta D.,Stanley J.T.,Holloway P.H.,Tan W.,Moudgil B.M.,Mericle R.A.TAT conjugated,FITC doped silica nanoparticles for bioimaging applications[J].Chemical Communications,2004,(24):2810-2811.
[23]Jain T.K.,Roy I.,De T.K.,Maitra A.Nanometer silica particles encapsulating active compounds:a novel ceramic drug carrier[J].Journal of the American Chemical Society,1998,120(43):11092-11095.
[24]Bagwe R.P.,Yang C.,Hilliard L.R.,Tan W.Optimization of Dye-Doped Silica Nanoparticles Prepared Using a Reverse Microemulsion Method[J].Langmuir,2004,20(19):8336-8342.
[25]Ye Z.,Tan,M,Wang G.,Yuan J.Preparation,characterization,and time-resolved fluorometric application of silica-coated terbium(Ⅲ) fluorescent nanoparticles[J].Analytical Chemistry,2004,76(3):513-518.
[26]Chang S.-Y.,Liu L.,Asher S.A.Preparation and properties of tailored morphology,monodisperse colloidal silica-cadmium sulfide nanocomposite[J].Journal of the American Chemical Society,1994,116(15):6739-6744.
[27]Gerion D.,Pinaud F.,Williams S.C.,Parak W.J.,Zanchet D.,Weiss S.,Alivisatos A.P.Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots[J].Journal of Physical Chemistry B,2001,105(37):8861-8871.
[28]Wang L.,Tan W.Multicolor FRET silica nanoparticles by single wavelength excitation [J].Nano Letters,2006,6(1):84-88.
[29]Santra S.,Zhang P.,Wang K.,Tapec R.,Tan W.Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers[J].Analytical Chemistry,2001,73(20):4988-4993.
[30]He X.-X.,Wang K.,Tan W.,Liu B.,Lin X.,He C.,Li D.,Huang S.,Li J.Bioconjugated nanoparticles for DNA protection from cleavage[J].Journal of the American Chemical Society,2003,125(24):7168-7169.
[31]Ow H.,Larson D.R.,Srivastava M.,Baird B.A.,Webb W.W.,Wiesner U.Bright and stable core-shell fluorescent silica nanoparticles[J].Nano Letters,2005,5(1):113-117.
[32]Bathe C.,Bartlett J.,Kong L.,Finnie K.,Lin H.Q.,Larkin M.,Calleja S.,Bush A.,Calleja G.Silica particles:a novel drug-delivery system[J].Advanced Materials,2004,16(21):1959-1966.
[33]Roy I.,Ohulchanskyy T.Y.,Bharali D.J.,Pudavar H.E.,Mistretta R.A.,Kaur N.,Prasad P.N.Optical tracking of organically modified silica nanoparticles as DNA carriers:A nonviral,nanomedicine approach for gene delivery[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(2):279-284.
[34]张立德,牟季美.纳米材料和纳米结构[M],科学出版社,北京,2001.
[35]Dormann J.L.,Fiorani D.Magnetic properties of fine particles[M].North-Holland Delta Series.Amsterden:Noth-Holland,1991,309-423.
[36]Katz E.,Willner I.Nanobiotechnology:integrated nanoparticle-biomolecule hybrid systems:synthesis,properties,and applications[J].Angewandte Chemie,International Edition,2004,43(45):6042-6108
[37]Hyeon T.,Lee S.S.,Park J.,Chung Y.,Na H.B.Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process[J].Journal of the American Chemical Society,2001,123(51):12798-12801.
[38]Guo Q.,Teng X.,Rahman S.,Yang H.Patterned Langmuir-Blodgett films of monodisperse nanoparticles of iron oxide using soft lithography[J].Journal of the American Chemical Society,2003,125(3):630-631.
[39]Lai J.-I.,Shaft Kurikka V.P.M.,Ulman A.,Loos K.,Lee Y.,Vogt T.,Lee W.-L.,Ong N.P.Controlling the size of magnetic nanoparticles using Pinronic block copolymer surfactants[J].Journal of Physical Chemistry B,2005,109(1):15-18.
[40]Sun S.,Zeng H.Size-controlled synthesis of magnetite nanoparticles[J].Journal of the American Chemical Society,2002,124(28):8204-8205.
[41]Sun S.,Zeng H.,Robinson D.B.,Raoux S.,Rice P.M.,Wang S.X.,Li G.Monodisperse MFe_2O_4(M=Fe,Co,Mn) Nanoparticles[J].Journal of the American Chemical Society,2004,126(1):273-279.
[42]Fried T.,Shemer G.,Markovich G.Ordered two-dimensional arrays of ferrite nanoparticles[J].Advanced Materials,2001,13(15):1158-1161.
[43]Kang Y.S.,Risbud S.,Rabolt J.F.,Stroeve P.Synthesis and Characterization of Nanometer-Size Fe_3O_4 and Fe_2O_3 Particles[J].Chemistry of Materials,1996,8(9):2209-2211.
[44]Hong C.-Y.,Jang I.J.,Horng H.E.,Hsu C.J.,Yao Y.D.,Yang H.C.Ordered structures in Fe_3O_4 kerosene-based ferrofluids[J].Journal of Applied Physics,1997,81(8,Pt.2A):4275-4277.
[45]Liao M.-H.,Chen D.-H.Preparation and characterization of a novel magnetic nano-adsorbent[J].Journal of Materials Chemistry,2002,12(12):3654-3659.
[46]Vaqueiro P.,Lopez-Quintela M.A.,Rivas J.Synthesis of yttrium iron garnet nanoparticles via coprecipitation in microemulsion[J].Journal of Materials Chemistry,1997,7(3):501-504.
[47]Shi J.,Verweij H.Synthesis and Purification of Oxide Nanoparticle dispersions by modified emulsion precipitation[J].Langmuir,2005,21(12):5570-5575.
[48]Zhou Z.H.,Wang J.,Liu X.,Chan H.S.O.Synthesis of Fe_3O_4 nanoparticles from emulsions[J].Journal of Materials Chemistry,2001,11(6):1704-1709.
[49]Vestal C.R.,Zhang Z.J.Synthesis and magnetic characterization of Mn and Co spinal ferrite-silica nanoparticles with tunable magnetic core[J].Nano Letters,2003,3(12):1739-1743.
[50]Santra S.,Tapec R.,Theodoropoulou N.,Dobson J.,Hebard A.,Tan W.Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion:the effect of nonionic surfactants[J].Langmuir,2001,17(10):2900-2906.
[51]Rondinone A.J.,Samia A.C.S.,Zhang Z.J.Superparamagnetic relaxation and magnetic anisotropy energy distribution in CoFe_2O_4 spinel ferrite nanocrystallites[J].Journal of Physical Chemistry B,1999,103(33):6876-6880.
[52]Tago T.,Hatsuta T.,Miyajima K.,Kishida M.,Tashiro S.,Wakabayashi K.Novel synthesis of silica-coated ferrite nanoparticles prepared using water-in-oil microemulsion[J].Journal of the American Ceramic Society,2002,85(9):2188-2194.
[53]Tartaj P.,Serna C.J.Synthesis of monodisperse superparamagnetic Fe/siliea nanospherical composites[J].Journal of the American Chemical Society,2003,125(51):15754-15755.[34]
[54]Vestal C.R.,Zhang Z.J.Synthesis and magnetic characterization of Mn and Co spinel ferrite-silica nanoparticles with tunable magnetic core[J].Nano Letters,2003,3(12):1739-1743.
[55]Lin Y.-S.,Wu S.-H.,Hung Y.,Chou Y.-H.,Chang C.,Lin M.-L.,Tsai C.-P.,Mou C.-Y.Multifunctional composite nanoparticles:magnetic,luminescent,and mesoporous[J].Chemistry of Materials,2006,18(22):5170-5172.
[56]Lu C.-W.,Hung Y.,Hsiao J.-K.,Yan M.,Chung T.-H.,Lin Y.-S.,Wu S.-H.,Hsu S.-C.,Liu H.-M.,Mou C.-Y.,Yang C.-S.,Huang D.-M.,Chen Y.-C.Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling[J].Nano Letters,2007,7(1):149-154.
[57]Kim J.,Lee J.E.,Lee J.,Yu J.H.,Kim B.C.,An K.,Hwang Y.,Shin C.-H.,Park J.-G.,Kim J.,Hyeon T.Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals[J].Journal of the American Chemical Society,2006,128(3):688-689.
[58]Yi D.K.,Selvan S.T.,Lee S.S.,Papaefthymiou G.C.,Kundaliya D.,Ying J.Y.Silica-coated nanocomposites of magnetic nanoparticles and quantum dots[J].Journal of the American Chemical Society,2005,127(14):4990-4991.
[59]Selvan S.T.,Patra P.K.,Ang C.Y.,Ying J.Y.Synthesis of silica-coated semiconductor and magnetic quantum dots and their use in the imaging of live cells[J].Angewandte Chemic,International Edition,2007,46(14):2448-2452.
[60]Santra S.,Tapec R.,Theodoropoulou N.,Dobson J.,Hebard A.,Tan W.Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion:the effect of nonionic surfactants[J].Langmuir,2001,17(10):2900-2906.
[61]Deng Y.-H.,Wang C.-C.,Hu J.-H.,Yang W.-L.,Fu S.-K.Investigation of formation of silica-coated magnetite nanoparticles via sol-gel approach[J].Colloids and Surfaces,A:Physicochemical and Engineering Aspects,2005,262(1-3):87-93.
[62]Lu Y.,Yin Y.,Mayers B.T.,Xia Y.Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol-gel approach[J].Nano Letters,2002,2(3):183-186.
[63]Zhao W.,Gu J.,Zhang L.,Chen H.,Shi J.Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure[J].Journal of the American Chemical Society,2005,127(25):8916-8917.
[64]Tovmachenko O.G.,Graf C.,van den Heuvel D.J.,van Blaaderen A.,Gerritsen H.C.Fluorescence enhancement by metal-core/silica-shell nanoparticles[J].Advanced Materials,2006,18(1):91-95.
[65]Liz-Marzan L.M.,Giersig M.,Mulvaney P.Synthesis of nanosized gold-silica core-shell particles[J].Langmuir,1996,12(18):4329-4335.
[66]Ohmori M,Matijevic E.Preparation and properties of uniform coated colloidal particles [J].Journal of Colloid and Interface Science,1992,150(2):594-598.
[67]Salgueirino-Maceira V.,Correa-Duarte M.A.,Spasova M.,Liz-Marzan L.M.,Farle M.Composite silica spheres with magnetic and luminescent functionalities[J].Advanced Functional Materials,2006,16(4):509-514.
[68]Chen M.,Gao L.,Yang S.,Sun J.Fabrication of well-defined water-soluble core/shell heteronanostructures through the SiO_2 spacer[J].Chemical Communications,2007,(12):1272-1274.
[69]Xu C.,Xu K.,Gu H.,Zheng R.,Liu H.,Zhang X.,Guo Z.,Xu B.Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles[J].Journal of the American Chemical Society,2004,126(32):9938-9939.
[70]Gu H.,Xu K.,Xu C.,Xu B.Biofunctional magnetic nanoparticles for protein separation and pathogen detection[J].Chemical Communications,2006,(9):941-949.
[71]Zhao X.,Tapec-Dytioco R.,Wang K.,Tan W.Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers[J].Analytical Chemistry,2003,75(14):3476-3483.
[72]Widder K.J.,Senyei Andrew E.,Scarpelli D.G.Magnetic microspheres:a model system for site specific drug delivery in vivo[J].Proceedings of the Society for Experimental Biology and Medicine,1978,158(2):141-146.
[73]Song H.-T.,Choi J.-S.,Huh Y.-M.,Kim S.,Jun Y.-W.,Suh J.-S.,Cheon J.Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling[J].Journal of the American Chemical Society,2005,127(28):9992-9993.
[74]Weissleder R.,Moore A.,Mahmood U.,Bhorade R.,Benveniste H.,Chiocca E.A.,Basilion J.P.In vivo magnetic resonance imaging of transgene expression[J].Nature Medicine,2000,6(3):351-354.
[75]Zhao M.,Beauregard D.A.,Loizou L.,Davletov B.,Brindle K.M.Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent[J].Nature Medicine,2001,7(11):1241-1244.
[76]Lee J.-H.,Jun Y.-W.,Yeon S.-I.,Shin J.-S.,Cheon J.Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma[J].Angewandte Chemie,International Edition,2006,45(48):8160-8162.
[77]Corr S.A.,Rakovich Y.P.,Gun'ko Y.K.Multifunctional magnetic-fluorescent nanocomposites for biomedical appfications[J].Nanoscale Research Letters,2008,3(3):87-104.
[78]Du G.H.,LiuZ.L.,Lu Q.H.,Xia X.,Jia L.H.,Yao K.L.,Chu Q.,Zhang S.M.Fe_3O_4/CdSe/ZnS magnetic fluorescent bifunctional nanocomposites[J].Nanotechnology,2006,17(12):2850-2854.
[79]Salgueirino-Maceira V.,Correa-Duarte M.A.,Spasova M.,Liz-Marzan L.M.,Farle M.Composite silica spheres with magnetic and luminescent functionalities[J].Advanced Functional Materials,2006,16(4):509-514.
[80]Lin Y.S.,Wu S.H.,Hung Y.,Chou Y.H.,Chang C.,Lin M.L.,Tsai C.P.,Mou C.Y.Multifunctional composite nanoparticles:magnetic,luminescent,and mesoporous[J].Chemistry of Materials,2006,18(22):5170-5172.
[81]Yi D.K.,Selvan S.T.,Lee S.S.,Papaefthymiou G.C.,Kundaliya D.,Ying J.Y.Silica-coated nanocomposites of magnetic nanoparticles and quantum dots[J].Journal of the American Chemical Society,2005,127(14):4990-4991.
[82]Mulder W.J.,Griffioen A.W.,Strijkers G.J.,Cormode D.P.,Nicolay K.,Fayad Z.A.Magnetic and fluorescent nanopatieles for multimodality imaging[J].Nanomedicine,2007,2(3):307-324.
[83]Zhang Y.,Wang S.N.,Ma S.,Guan J.J.,Li D.,Zhang X.D.,Zhang Z.D.Self-assembly multifunctional nanocomposites with Fe_3O_4 magnetic core and CdSe/ZnS quantum dots shell[J].Journal of Biomedical Materials Research,Part A,2008,85(3):840-846.
[84]Lu H.,Yi G.,Zhao S.,Chen D.,Guo L.,Cheng J.Synthesis and characterization of multi-functional nanoparticles possessing magnetic,up-conversion fluorescence and bio-affinity properties[J].Journal of Materials Chemistry,2004,14(8):1336-1341.
[85]Abu-Reziq R.,Alper H.,Wang D.,Post M.L.Metal supported on dendronized magnetic nanoparticles:highly selective hydroformylation catalysts[J].Journal of the American Chemical Society,2006,128(15):5279-5282.
[86]Ding S.,Xing Y.,Radosz M.,Shen Y.Magnetic nanoparticles supported catalyst for transfer radical polymerization[J].Macromolecules,2006,39(19):6399-6405.
[87]Chen D.H.,Liao M.H.Preparation and characterization of YADH-bound magnetic nanoparticles[J].Journal of Molecular Catalysis B:Enzymatic,2002,16(5-6):283-291.
[88]Tsang S.C.,Yu C.H.,Gao X.,Tam K.Silica-encapsulated nanomagnetic particles as a new recoverable biocatalyst carrier[J].Journal of Physical Chemistry B,2006,110(34):16914-16922.
[89]Yi D.K.,Lee S.S.,Ying J.Y.Synthesis and application of magnetic nanocomposite catalysts[J].Chemistry of Materials,2006,18(10):2459-2461.
[90]Chen X.,Zhao T.,Zou J.,A Novel Mimetic Peroxidase Catalyst by Using Magnetite-Containing Silica Nanoparticles as Carriers[J],Microchimica Acta,2008,(in press).
[91]Lyon J.L.,Fleming D.A.,Stone M.B.,Schiffer P.,Williams M.E.Synthesis of Fe oxide core/Au shell nanoparticles by iterative hydroxylamine seeding[J].Nano Letters,2004,4(4):719-723.
[92]Gmucova K,Weis M,Nadazdy V,Majkova E.Orientation ordering of nanoparticle Ag/Co cores controlled by electric and magnetic fields[J].ChemPhyChem,2008,9(7):1036-1039.
[93]Han X.,Wang Y.S.Studies on the synthesis and microwave absorption properties of Fe_3O_4/polyaniline FGM[J].Physica Scripta,2007,T129:335-339.
[94]de Oliveira H.P.,Andrade C.A.S.,de Melo C.P.Electrical impedance spectroscopy investigation of surfactant-magnetite-polypyrrole particles[J].Journal of Colloid and Interface Science.2008,319(2):441-449.
[95]Aphesteguy J.C.,Jacobo S.E.Synthesis of a soluble polyaniline-ferrite composite:magnetic and electric properties[J].Journal of Materials Science.2007,42(17):7062-7068.
[96]Koo Y.S.,Kim D.H.,Jung J.H.Synthesis of electric/magnetic oxide core/shell nanoparticles and their characteristics[J].Journal of the Korean Physical Society.2006,48(4):677-680.
[97]Okumura M.,Nakamara S.,Tsubota S.,Nakamura T.,Azuma M.,Chemical vapor deposition of gold on Al_2O_3,SiO_2,and TiO_2 for the oxidation of CO and of H_2[J]Catalysis Letters,1998,51(1,2),53-58.
[98]Okumura M.,Akita T.,Haruta M.,Hydrogenation of 1,3-butadiene and of crotonaldehyde over highly dispersed Au catalysts[J].Catalysis Today,2002,74(3-4):265-269.
[99]Mohr C.,Hofmeister H.,Claus P.The influence of real structure of gold catalysts in the partial hydrogenation of acrolein[J].Journal of Catalysis,2003,213(1):86-94.
[100]Porta F.,Prati L.,Rossi M.,Collucia S.,Martra G.Metal sols as a useful tool for heterogeneous gold catalyst preparation:reinvestigation of a liquid phase oxidation[J].Catalysis Today,2000,61(1-4):165 - 172.
[101]Landon P.,Collier P.J.,Papworth A.J.,Kiely C.J.,Hutchings G.J.Direct formation of hydrogen peroxide from H_2/O_2 using a gold catalyst[J].Chemical Communications,2002,(18):2058-2059.
[102]Shi F.,Deng Y.Polymer-Immobilized Gold Catalysts for the Efficient and Clean Syntheses of Carbamates and Symmetrical Ureas by Oxidative Carbonylation of Aniline and Its Derivatives[J].Journal of Catalysis,2002,211(2):548-551.
[103]Kim S.-W.,Son S.U.,Lee S.S.,Hyeon T.,Chung Y.K.Colloidal cobalt nanoparticles:a highly active and reusable Pauson-Khand catalyst[J].Chemical Communications,2001,(23):2212-2213.
[104]Pedersen C.J.The discovery of crown ethers[J].Angewandte Chemie,1988,100(8):1053-1059.
[105]Lehn J.M.Supramolecular chemistry-scope and perspectives molecules,supermolecules,and molecular devices[J].Angewandte Chemie,International Edition,1988,27(1):89-112.
[106]Cram D.J.The design of molecular hosts,guests,and their complexes[J].Angewandte Chemie,International Edition,1988,27(8):1009-1020.
[107]高鸿 分析化学前沿[M].科学出版社,北京,1991.
[108]de Silva A.P.,Gunaratne H.Q.N.,Gunnlaugsson T.,Huxley A.J.M.,McCoy C.P.,Rademacher J.T.,Rice T.E.Signaling recognition events with fluorescent sensors and switches[J].Chemical Reviews,1997,97(5):1515-1566.
[109]江云宝 氢键介导的分子识别与荧光传感,分析化学的明天[M].科学出版社,北京,2003.
[110]Wu S.Some photo-chemical and photo-physical problems in fluorescent chemical sensor study[J].Progress in Chemistry,2004,16(2):174-183.
[111]Lee S.J.,Lee S.S.,Lee J.Y.,Jung H.J.A functionalized inorganic nanotube for the selective detection of copper(Ⅱ) ion[J].Chemistry of Materials,2006,18(20):4713-4715.
[112]Lee S.J.,Lee S.S.,Lah M.S.,Hong J.-M.,Jung J.H.Organic-inorganic hybrid nanomaterial as a new fluorescent chemosensor and adsorbent for copper ion[J].Chemical Communications,2006,(43):4539-4541.
[113]Atia A.A.Studies on the interaction of mercury(Ⅱ) and uranyl(Ⅱ) with modified chitosan resins[J].Hydrometallurgy,2005,80(1-2):13-22.
[114]Palomares E.,Vilar R.,Durrant J.R.Heterogeneous colorimetric sensor for mercuric salts[J].Chemical Communications,2004,(4):362-363.
[1]Martin C.R.,Mitchell D.T.Nanomaterials in analytical chemistry[J].Analytical Chemistry,1998,70(9):322A-327A.
[2]Paull R.,Wolfe J.,Hebert P.,Sinkula M.Investing in nanotechnology[J].Nature Biotechnology,2003,21(10):1144-1147.
[3]Whitesides G.M.The 'right' size in nanobiotechnology[J].Nature Biotechnology,2003,21(10):1161-1165.
[4]Zhu Q.Z.,Li Q.G.,Lu J.Z.,Xu J.G.Application of thiamine as a fluorogenic substrate in the determination of hydrogen peroxide based on the catalytic effect of hemin[J].Analytical Letters,1996,29(10):1729-1740.
[5]Zhang G.F.,Dasgupta P.K.Hematin as a peroxidase substitute hi hydrogen peroxide determinations[J].Analytical Chemistry,1992,64(5):517-522.
[6]Chen Q.Y.,Li D.H.,Zhu Q.Z.,Zheng H.,Xu J.G.Application of iron-tetrasulfonatophthalocyanine as a newmimetic peroxidase in the determination of hydrogen peroxide with p-hydroxyphenylpropionic acid as a substrate[J].Analytica Chimica Acta,1999,381(2-3):175-182.
[7]Zhu Q.Z.,Yang H.H.,Li D.H.,Chen Q.Y.,Xu J.G.A novel mimetic enzymatic fluorescence immunoassay for hepatitis B surface antigen by using a thermal phase separating polymer[J].Analyst,2000,125(12):2260-2263.
[8]Chen L.H.,Liu L.Z.,Shen H.X.Mn(Ⅱ)- sodium dodecyl sulphate complex mimic enzyme-catalyzed fluorescence quenching of Pyronine B by hydrogen peroxide[J].Analytica Chimica Acta,2003,480(1):143-150.
[9]Yang H.H.,Zhu Q.Z.,Chen Q.Y.,Xu J.G.,Li D.H.Temperature modulated solubility and activity alteration for oligo-(N-isopropylacrylamide)-iron tetrasulfonatophthalocyanine conjugates as a new mimetic peroxidase[J].Analyst,2000,125(4):719-724.
[10]Mesu J.G.,Baute D.,Tromp H.J.,Faassen E.E.,Weckhuysen B.M.Synthesis and characterization of zeolite encaged enzymemimetic copper histidine complexes[J].Studies in Surf ace Science and Catalysis,2002,143:287-293.
[11]Yang W.,Zheng H.,Yuan W.T.,Xu J.G.Silica-hemin composite nanoparticles as new biocatalyst to highly sensitive determination of glucose in human serum[J].Analytical Sciences,2004,20(9):1265-1270.
[12]Zou J.L.,Chen X.L.Silica nanoparticles as catalyst carriers to the highly sensitive determination of thiamine[J].Microchemical Journal,2007,86(1):42-47.
[13]Nomura A.,Shin S.,Mehdi O.O.,Kauffmann J.M.Preparation,characterization,and application of an enzyme-immobilized magnetic microreactor for flow injection analysis [J].Analytical Chemistry,2004,76(18):5498-5502.
[14]Yoon T.J.,Kim J.S.,Kim B.G.,Yu K.N.,Cho M.H.,Lee J.K.Multifunctional nanoparticles possessing a "Magnetic Motor Effect" for drug or gene delivery[J].Angewandte Chemie,International Edition,2005,44(7):1068-1071.
[15]Goetz V.,Remaud M.,Graves D.J.A novel magnetic silica support for use in chromatographic and enzymic bioprocessing[J].Biotechnology and Bioengineering,1991,37(7):614-626.
[16]del Campo A.,Sen T.,Lellouche J.P.,Bruce I.J.Multifunctional magnetite and silica- magnetite nanoparticles:synthesis,surface activation and applications in life sciences [J].Journal of Magnetism and Magnetic Materials,2005,293(1):33-40.
[17]He Y.P.,Wang S.Q.,Li C.R.,Miao Y.M.,Wu Z.Y.,Zou B.S.Synthesis and characterization of functionalized silica-coated Fe_3O_4 superparamagnetic nanocrystals for biological applications[J].Journal of Physics D:Applied Physics,2005,38(9):1342-1350.
[18]Ashtari P.,He X.X.,Wang K.M.,Gong P.An efficient method for recovery of target ssDNA based on amino-modified silicacoated magnetic nanoparticles[J].Talanta,2005,67(3):548-554.
[19]Yu D.H.,Blankert B.,Bodoki E.,Bollo S.,Vire J.C.,Sandulescu R.,Nomuraa A.,Kauffmann J.M.Amperometric biosensor based on horseradish peroxidase-immobilised magnetic microparticles[J].Sensors and Actuators,B:Chemical,2006,113(2):749-754.
[20]Butterworth M.D.,Illum L.,Davis S.S.Preparation of ultrafine silica- and PEG-coated magnetite particles[J].Colloids and Surfaces,A:Physicochemical and Engineering Aspects,2001,179(1):93-102.
[21]Szabo D.V.,Vollath D.Nanocomposites from coated nanoparticles[J].Advanced Materials,1999,11(15):1313-1316.
[22]Van Zoonen P.,Kamminga D.A.,Gooijer C.,Velthorst N.H.,Frei R.W.Flow injection determination of hydrogen peroxide by means of a solid-state-peroxyoxalate chemiluminescence reactor[J].Analytica Chimica Acta,1985,167:249-256.
[23]Ishida J.,Arakawa H.,Takada M.,Yamaguchi M.Development of a novel luminol-related compound,3-propyl-7,8-dihydropyridazino-[4,5-g]quinoxaline-2,6,9(1H)-trione,and its application to hydrogen peroxide and serum glucose assays[J].Analyst,1995,120(4):1083-1086.
[24]Marie L.,Greenway G.M.Determination of hydrogen peroxide in rainwater in a miniaturised analytical system[J].Analytica Chimica Acta,2005,548(1-2):20-25.
[25]Yang L.,Janle E.,Huang T.H.,Gitzen J.,Kissinger P.T.,Vreeke M.,Heller A.Applications of "wired" peroxidase electrodes for peroxide determination in liquid chromatography coupled to oxidase immobilized enzyme reactors[J].Analytical Chemistry,1995,67(8):1326-1331.
[26]Park T.M.Amperometric determination of hydrogen peroxide by utilizing a sol-gel-derived biosensor incorporating an osmium redox polymer as mediator[J].Analytical Letters,1999,32(2):287-298.
[27]Gundogan-Paul M.,Ozyoruk H.,Celebi S.S.,Yildiz A.Amperometric enzyme electrode for hydrogen peroxide determination prepared with horseradish peroxidase immobilized in polyvinylferrocenium(PVFt)[J].Electroanalysis,2002,14(7-8):505-511.
[28]Johnson K.S.,Sakamoto-Arnold C.M.,Willason S.W.,Beehler C.L.Reagent-injection flow analysis:application to the determination of nanomolar levels of hydrogen peroxide in seawater[J].Analytica Chimica Acta,1987,201:83-94.
[29]Almuaibed A.M.,Townshend A.Flow spectrophotometric method for determination of hydrogen peroxide using a cation exchanger for preconcentration[J].Analytica Chimica Acta,1994,295(1-2):159-163.
[30]Yuan H.,Cai R.X.,Pan Z.T.Catalytical kinetic determination of hydrogen peroxide using iron-tetrasulfonatophthalocyanine(with gamma-CD) as a mimetic enzyme of peroxidase[J].Analytical Letters,2003,36(2):277-286.
[31]Hwang H.,Dasgupta P.K.Fluorometric flow injection determination of aqueous peroxides at nanomolar level using membrane reactors[J].Analytical Chemistry,1986,58(7):1521-1524.
[32]Tanner R.L.,Markovits G.Y.,Ferreri E.M.,Kelly T.J.Sampling and determination of gas-phase hydrogen peroxide following removal of ozone by gas-phase reaction with nitric oxide[J].Analytical Chemistry,1986,58(8):1857-1865.
[33]Miller W.L.,Kester D.R.Hydrogen peroxide measurement in seawater by (p-hydroxyphenyl)acetic acid dimerization[J].Analytical Chemistry,1985,60(24):2711-2715.
[34]Li Y.Z.,Townshend A.Evaluation of the adsorptive immobilisation of horseradish peroxidase on PTFE tubing in flow systems for hydrogen peroxide determination using fluorescence detection[J].Analytica Chimica Acta,1998,359(1-2):149-156.
[35]Chen X.L.,Li D.H.,Yang H.H.,Zhu Q.Z.,Zheng H.,Xu J.G.Study of tetra-substituted amino aluminum phthalocyanine as a new red-region substrate for the fluorometric determination of peroxidase and hydrogen peroxide[J].Analytica Chimica Acta,2001,434(1):51-58.
[36]Tang B.,Wang Y.,Sun Y.,Shen H.X.Spectrofluorimetric determination of hydrogen peroxide with 2-hydroxy-1-naphthaldehyde salicyloylhydrazone(HNSH) as the substrate for horseradish peroxidase(HRP)[J].Spectrochimica Acta.Part A,Molecular and Biomolecular Spectroscopy,2002,58(1):141-148.
[37]Kang Y.S.,Risbud S.,Rabolt J.F.,Stroeve P.synthesis and characterization of nanometer-size Fe_3O_4 and γ-Fe_2O_3 particles[J].Chemistry of Materials,1996,8(9):2209-2211.
[38]Stober W.,Fink A.Controlled growth of monodisperse silica spheres in the micron size Range[J].Journal of Colloid and Interface Science,1968,26(1):62-69.
[39]Chang S.Y.,Liu L.,Asher S.A.Creation of templated topological morphologies in colloidal silica[J],Journal of the American Chemical Society,1994,116(15):6745-6747.
[40]Arriagada F.J.,Osseo-Asare K.Synthesis of nanosize silica in a nonionic water-in-oil microemulsion:efffects of the water/surfactant molar ratio and ammonia concentration [J],Journal of Colloid and Interface Science,1999,211(2):210-220.
[41]Van Blasderen A.,Vrij A.Synthesis and characterization of colloidal dispersions of fluorescent,monodisperse silica spheres[J],Langmuir,1992,8(12):2921-2931.
[42]Yin D.K.,Selvan S.T.,Lee S.S.,Papaefthymiou G.C.,Kundaliya D.,Ying J.Y.Silica-coated nanocomposites of magnetic nanoparticles and quantum dots[J],Journal of the American Chemical Society,2005,127(14):4990-4991.
[43]Nimesha S.,Manchandac R.,Kumara R.,Saxena A.,Chaudhary P.,Yadav V.,Mozumdar S.,Chandra R.Preparation,characterization and in vitro drug release studies of novel polymeric nanoparticles[J],International Journal of Pharmaceutics,2006,323(1-2):146-152.
[44]Saxena A.,Sachin K.,Bohidar H.B.,Verma A.K.Effect of molecular weight heterogeneity on drug encapsulation efficiency of gelatin nano-particles[J],Colloids and Surfaces,B:Biointerfaces,2005,45(1):42-48.
[45]Santra S.,Zhang P.,Wang K.,Tapec R.,Tan W.Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers[J].Analytical Chemistry,2001,73(20):4988-4993.
[46]Ow H.,Larson D.R.,Srivastava M.,Baird B.A.,Webb W.W.,Wiesner U.Bright and stable core-shell fluorescent silica nanoparticles.Nano Letters,2005,5(1):113-117.
[47]Bele M.,Siiman O.,Matijevic E.Preparation and flow cytometry of uniform silica-fluorescent dye microspheres[J].Journal of Colloid and Interface Science,2002,254(2):274-282.
[48]Heule M.,Rezwan K.,Cavalli L.,Gauckler L.J.A miniaturized enzyme reactor based on hierarchically shaped porous ceramic microstruts[J].Advanced Materials,2003,15(14):1191-1194.
[49]Briggs G.E.,Haldane J.B.S.Note on the kinetics of enzyme action[J].Biochemical Journal,1925,19(6):338-339.
[50]Lineweaver H.,Burk D.Determination of enzyme dissociation constants[J].Journal of the American Chemical Society,1934,56:658-666.
[1]Zhu C.Q.,Zhuo S.J.,Chen J.L.,Wu Y.Q.,Li Y.X.,Li D.H.,Zheng H.,Xu J.G.A kinetic fluorometric method for the determination of nucleic acids using a ternary equilibrium system of nucleic acids-iron(Ⅲ) tetracarboxy phthalocyanine-poly-lysine coupled with the oxidation reaction between hydrogen peroxide and DL-tyrosine[J].Analytica Chimica Acta,2004,514(2):247-252.
[2]Chen L.H.,Liu L.Z.,Shen H.X.Studies on mimic peroxidase behaviors of molybdenum(Ⅵ)-sodium dodecyl sulphate complex for the determination of hydrogen peroxide and glucose[J].Analytical Letters,2004,37(4):561-573.
[3]Chen L.H.,Liu L.Z.,Shen H.X.Mn(Ⅱ)-sodium dodecyl sulphate complex mimic enzyme-catalyzed fluorescence quenching of Pyronine B by hydrogen peroxide[J].Analytica Chimica Acta,2003,480(1):143-150.
[4]Chen Q.Y.,Li D.H.,Zhu Q.Z.,Yang H.H.,Zheng H.,Xu J.G.Investigation on the potential use of the mimetic peroxidase-catalyzed reaction of hydrogen peroxide and o-hydroxyphenylfluorone in fluorescence analysis[J].Analytica Chimica Acta,2000,406(2):209-215.
[5]Chen M.,Cai W.P.,Zhu Q.Z.,Wang X.S.,Xu J.G.Determination of glucose based on the effect of photons as a substitute for glucose oxidase[J].Analytica Chimica Acta,1999,388(1-2):11-17.
[6]Zhu Q.Z.,Zheng X.Y.,Xu J.G..Application of hemin as a labeling reagent in mimetic enzyme immunoassay for hepatitis B surface antigen[J].Analytical Letters,1998,31(6):963-971.
[7]Zhu Q.Z.,Liu F.H.,Xu J.G.,Su W.J.,Huang J.W.Mimetic-enzyme fluorescence immunoassay using a thermal phase separating polymer[J].Analyst,1998,123(5):1131-1134.
[8]Robinson P.J.,Dunnill P.,Lilly M.D.Properties of magnetic supports in relation to immobilized enzyme reactors[J].Biotechnology and Bioengineering,1973,15(3):603-606.
[9]Zhao X.,Tapec-Dytioco R.,Wang K.,Tang W.Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers[J].Analytical Chemistry,2003,75(14):3476-3483.
[10]Guo J.,Yang W.,Wang C.,He J.,Chen J.Poly(N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres:preparation,characterization,and biomedical applications[J].Chemistry of Materials,2006,18(23):5554-5562.
[11]Fernandez-Pacheco R.,Arruebo M.,Marquina C.,Ibarra R.,Arbiol J.,Santamaria J.Highly magnetic silica-coated iron nanoparticles prepared by the arc-discharge method[J].Nanotechnology,2006,17(5):1188-1192.
[12]Yoon T.J.,Yu K.N.,Kim E.,Kim J.S.,Kim B.G.,Yun S.H.,Sohn B.H.,Cho M.H.,Lee J.K.,Park S.B.Specific targeting,cell sorting,and bioimaging with smart magnetic silica core-shell nanomaterials[J].Small,2006,2(2):209-215.
[13]Tan W.,Wang K.,He X.,Zhao X.J.,Drake T.,Wang L.,Bagwe R.P.Bionanotechnology based on silica nanoparticles[J].Medicinal Research Reviews,2004,24(5):621-638.
[14]Fried T.,Shemer G.,Markovich G.Ordered two-dimensional arrays of ferrite nanoparticles[J].Advanced Materials,2001,13(15):1158-1161.
[15]Wang L,Bao J.,Wang L.,Zhang F.,Li Y.One-pot synthesis and bioapplicaiton of amine-functionalized magnetite nanoparticles and hollow nanospheres[J].Chemistry-A European Journal,2006,12(24):6341-6347.
[16]Kang Y.S.,Risbud S.,Rabolt J.F.,Stroeve P.Synthesis and characterization of nanometer-size Fe_3O_4 and γ-Fe_2O_3 particles[J].Chemistry of Materials,1996,8(9):2209-2211.
[17]Liu S.,Zhang H.L.,Liu T.C.,Liu B.,Cao Y.C.,Huang Z.L.,Zhao Y.D.,Luo Q.M.Optimization of the methods for introduction of amine groups onto the nanoparticles surface[J].Journal of Biomedical Materials Research,Part A,2007,80(3):752-757.
[18]Bagwe R.P.,Hilliard L.R.,Tang W.Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding[J].Langmuir,2006,22(9):4357-4362.
[19]Barnakov Y.A.,Yu M.H.,Rosenzweig Z.Manipulation of the magnetic properties of magnetite-silica nanocomposite materials by controlled Stober synthesis[J].Langmuir,2005,21(16):7524-7527.
[20]Taylor I.,Howard A.G.Measurement of primary amine groups on surface-modified silica and their role in metal binding[J].Analytica Chimica Acta,1992,271(1):77-82.
[21]Heule M.,Rezwan K.,Cavalli L.,Ganckler L.J.A miniaturized enzyme reactor based on hierarchically shaped porous ceramic microstruts[J].Advanced Materials,2003,15(14):1191-1194.
[22]Li X.Z.,Wan L.,Zhou C.,Guan T.T.,Li J.,Zhang Y.H.Preliminary studies of application of CdTe nanocrystals and dextran-Fe_3O_4 magnetic nanoparticles in sandwich immunoassay[J].Clinica Chimica Acta,2007,378(1-2):168-174.
[23]Ribone M.E.,Belluzo M.S.,Pagani D.,Macipar I.S.,Lagier C.M.Amperometric bioelectrode for specific human immunoglobulin G determination:Optimization of the method to diagnose American trypanosomiasis[J].Analytical Biochemistry,2006,350(1):61-70.
[24]Zhao H.W.,Huang C.Z.,Li Y.F,.Immunoassay by detecting enhanced resonance light scattering signals of immunocomplex using a common spectrofluorometer[J].Talanta,2006,70(3):609-614.
[25]林学颜 免疫学基础[M].福建科学技术出版社,福建,1980.
[1]Holla B.S.,Kalluraya B.,Sridhar K.R.,Drake E.,Thomas L.M.,Bhandary K.K.,Levine M.J.Synthesis,structural characterization,crystallographic analysis and antibacterial properties of some nitrofuryl triazolo[3,4-b]-1,3,4-thiadiazines[J].European Journal of Medicinal Chemistry,1994,29(4):301-308.
[2]Demirayak S.,Benkli K.,Guven K.Synthesis and antimicrobial activities of some 3-arylamino-5-[2-(substituted 1-imidazolyl)ethyl]-1,2,4-triazole derivatives[J].European Journal of Medicinal Chemistry,2000,35(11):1037-1040.
[3]Liu F.M.,Wang B.L.,Lu W.J.Synthesis of trifluoromethyl-substituted 1,2,4-triazole mannich bases[J].Chinese Journal of Organic Chemistry,2000,20(5):738-742.
[4]Mishra P.,Gupta P.N.,Shakya A K.Synthesis of some Schiff bases of 3-amino-2-methyiquinazolin-4(3H)-ones and their antimicrobial activities[J].Journal of the Indian Chemical Society,1991,68(11):618-619.
[5]Srivastava S.K.,Pathak R.B.,Babel S.C.Synthesis of schiff base,2,5-disubstituted-1,3,4-oxadiazoles and 2,3-disubstituted-4-thiazolidinones as antifungal agents[J].Journal of the Indian Chemical Society,1991,68(2):113-114.
[6]Li G.,Zhang D.Determining silver accurately by method of sodium chloride deposit-residue potential titration[J].Precious Metals,2005,26(4):27-30.
[7]Wang X.Determination of Cu,Ag,As in lead and lead alloys by ICP-AES[J].Chemical Analysis and Meterage,2005,14(6):22-24.
[8]Lee S.J.,Lee S.S.,Lee J.Y.,Jung H.J.A functionalized inorganic nanotube for the selective detection of copper(Ⅱ) ion[J].Chemistry of Materials,2006,18(20):4713-4715.
[9]Lee S.J.,Lee S.S.,Lah M.S.,Hong J.-M.,Jung J.H.Organic-inorganic hybrid nanomaterial as a new fluorescent chemosensor and adsorbent for copper ion[J].Chemical Communications,2006,(43):4539-4541.
[10]Kim T.H.,Jung J.H.,Choi J.K.,Choi Y.H.,Lee S.J.,Seo M.L.,Kim J.S.Fluorescent calix[4]arene-appended silica nanotubes as selective chemosensor and adsorbent for Pb~(2+)ion[J].Chemistry Letters,2007,36(3):360-361.
[11]Atia A.A.Studies on the interaction of mercury(Ⅱ) and uranyl(Ⅱ) with modified chitosan resins[J].Hydrometallurgy,2005,80(1-2):13-22.
[12]Palomares E.,Vilar R.,Durrant J.R.Heterogeneous colorimetric sensor for mercuric salts[J].Chemical Communications,2004,(4):362-363.
[13]Nath M.,Sulaxna,Song X.,Eng G.Organotin(Ⅳ) triazolates:synthesis and their spectral characterization[J].Journal of Organometallic Chemistry,2006,691(8):1649-1657.
[14]Koparir M.,Cetin A.,Cansiz A.5-Furan-2yl[1,3,4]oxadiazole-2-thlol,5-furan-2yl-4H[1,2,4]triazole-3-thiol and their thiol-thione tautomerism[J].Molecules,2005,10(2):475-480.
[15]E1-Kemary M.A.,E1-Khouly M.E.,Ito O.Photophysical characteristics of two 4,6-disubistituted-3-cyanopyridin-2(1H)-thiones in various solvents[J].Journal of Photochemistry and Photobiology A:Chemistry,2000,137(2-3):105-113.
[16]Martos-Calvente R.,de la Pena O'Shea V.A.,Campos-Martin J.M.,Fierro J.L.G.The usefulness of density functional theory to describe the tautomeric equilibrium of 4,6-dimethyl-2-mercaptopyrimidine in solution[J].Journal of Physical Chemistry A,2003,107(38):7490-7495.
[2]Laval J.-M.,Chopineau J.,Thomas D.Nanotechnology:R&D challenges and opportunities for application in biotechnology[J].Trends in Biotechnology,1995,13(11):470-480.
[3]Siegel R.W.,Hu E.,Roco M.C.Nanostructure sience and technology:R&D status and trends in nanoparticles,nanostructured materials,and nanodevices[R].1999.
[4]West J.L.,Halas N.J.Applications of nanotechnology to biotechnology[J].Current Opinion in Biotechnology,2000,11(2):215-217.
[5]Barbe C.,Bartlett J.,Kong L.,Finnie K.,Lin H.Q.,Larkin M.,Calleja S.,Bush A.,Calleja G.Silica particles:a novel drug-delivery system[J].Advanced Materials,2004,16(21):1959-1966.
[6]Tan W.,Wang K.,He X.,Zhao X.J.,Drake T.,Wang L.,Bagwe R.P.Bionanotechnology based on silica nanoparticles[J].Medicinal Research Reviews,2004,24(5):621-638.
[7]Stoeber W.,Fink A.,Bohn E.Controlled growth of monodisperse silica spheres in the micron size range[J].Journal of Colloid and Interface Science,1968,26(1):62-69.
[8]Van Helden A.K.,Jansen J.W.,Vrij,A.Preparation and characterization of spherical monodisperse silica dispersions in nonaqucous solvents[J].Journal of Colloid and Interface Science,1981,81(2):354-368.
[9]Tan,C.G.,Bowen B.D.,Epstein N.Production of monodisperse colloidal silica spheres:effect of temperature[J].Journal of Colloid and Interface Science,1987,118(1):290-293.
[10]Nyffenegger R.,Quellet C.,Ricka J.Synthesis of fluorescent,monodisperse,colloidal silica particles[J].Journal of Colloid and Interface Science,1993,159(1):150-157.
[11]Coenen S.,De Kruif C.G.Synthesis and growth of colloidal silica particles[J].Journal of Colloid and Interface Science,1988,124(1):104-110.
[12]Van Blaaderen A.,Imhof A.,Hage W.,Vrij A.Three-dimensional imaging of submicrometer colloidal particles in concentrated suspensions using confocal scanning laser microscopy[J].Langmuir,1992,8(6):1514-1517.
[13]Van Blaaderen A.,Vrij A.Synthesis and characterization of colloidal dispersions of fluorescent,monodisperse silica spheres[J].Langmuir,1992,8(12):2921-2931.
[14]Verhaegh N.A.M.,Van Blaaderen A.Dispersions of rhodamine-labeled silica spheres:synthesis,characterization,and fluorescence confocal scanning laser microscopy[J].Langmuir,1994,10(5):1427-1438.
[15]Imhof A.,Megens M.,Engelberts J.J.,De Lang D.T.N.,Sprik R.,Vos W.L.Spectroscopy of Fluorescein(FITC) dyed colloidal silica spheres[J].Journal of Physical Chemistry B,1999,103(9):1408-1415.
[16]Ow H.,Larson D.R.,Srivastava M.,Baird B.A.,Webb W.W.,Wiesner U.Bright and stable core-shell fluorescent silica nanoparticles[J].Nano Letters,2005,5(1):113-117.
[17]Lindberg R.,Sjoeblom J.,Sundholm G.Preparation of silica particles utilizing the sol-gel and the emulsion-gel processes[J].Colloids and Surfaces,A:Physicochemical and Engineering Aspects,1995,99(1):79-88.
[18]Osseo-Asare K.,Arriagada F.J.Preparation of silica nanoparticles in a non-ionic reverse micellar system[J].Colloids and Surfaces,1990,50:321-339.
[19]Arriagada F.J.,Osseo-Assare K.Synthesis of nanosize silica in aerosol OT reverse microemulsions[J].Journal of Colloid and Interface Science,1995,170(1):8-17.
[20]Zhao X.,Bagwe R.P.,Tan W.,Development of organic-dye-doped silica nanoparticles in a reverse microemulsion[J].Advanced Materials,2004,16(2):173-176.
[21]He X.-X.,Wang K.,Tan W.,Liu B.,Lin X.,He C.,Li D.,Huang S.,Li J.Bioconjugated nanoparticles for DNA protection from cleavage[J].Journal of the American Chemical Society,2003,125(24):7168-7169.
[22]Santra S.,Yang H.,Dutta D.,Stanley J.T.,Holloway P.H.,Tan W.,Moudgil B.M.,Mericle R.A.TAT conjugated,FITC doped silica nanoparticles for bioimaging applications[J].Chemical Communications,2004,(24):2810-2811.
[23]Jain T.K.,Roy I.,De T.K.,Maitra A.Nanometer silica particles encapsulating active compounds:a novel ceramic drug carrier[J].Journal of the American Chemical Society,1998,120(43):11092-11095.
[24]Bagwe R.P.,Yang C.,Hilliard L.R.,Tan W.Optimization of Dye-Doped Silica Nanoparticles Prepared Using a Reverse Microemulsion Method[J].Langmuir,2004,20(19):8336-8342.
[25]Ye Z.,Tan,M,Wang G.,Yuan J.Preparation,characterization,and time-resolved fluorometric application of silica-coated terbium(Ⅲ) fluorescent nanoparticles[J].Analytical Chemistry,2004,76(3):513-518.
[26]Chang S.-Y.,Liu L.,Asher S.A.Preparation and properties of tailored morphology,monodisperse colloidal silica-cadmium sulfide nanocomposite[J].Journal of the American Chemical Society,1994,116(15):6739-6744.
[27]Gerion D.,Pinaud F.,Williams S.C.,Parak W.J.,Zanchet D.,Weiss S.,Alivisatos A.P.Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots[J].Journal of Physical Chemistry B,2001,105(37):8861-8871.
[28]Wang L.,Tan W.Multicolor FRET silica nanoparticles by single wavelength excitation [J].Nano Letters,2006,6(1):84-88.
[29]Santra S.,Zhang P.,Wang K.,Tapec R.,Tan W.Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers[J].Analytical Chemistry,2001,73(20):4988-4993.
[30]He X.-X.,Wang K.,Tan W.,Liu B.,Lin X.,He C.,Li D.,Huang S.,Li J.Bioconjugated nanoparticles for DNA protection from cleavage[J].Journal of the American Chemical Society,2003,125(24):7168-7169.
[31]Ow H.,Larson D.R.,Srivastava M.,Baird B.A.,Webb W.W.,Wiesner U.Bright and stable core-shell fluorescent silica nanoparticles[J].Nano Letters,2005,5(1):113-117.
[32]Bathe C.,Bartlett J.,Kong L.,Finnie K.,Lin H.Q.,Larkin M.,Calleja S.,Bush A.,Calleja G.Silica particles:a novel drug-delivery system[J].Advanced Materials,2004,16(21):1959-1966.
[33]Roy I.,Ohulchanskyy T.Y.,Bharali D.J.,Pudavar H.E.,Mistretta R.A.,Kaur N.,Prasad P.N.Optical tracking of organically modified silica nanoparticles as DNA carriers:A nonviral,nanomedicine approach for gene delivery[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(2):279-284.
[34]张立德,牟季美.纳米材料和纳米结构[M],科学出版社,北京,2001.
[35]Dormann J.L.,Fiorani D.Magnetic properties of fine particles[M].North-Holland Delta Series.Amsterden:Noth-Holland,1991,309-423.
[36]Katz E.,Willner I.Nanobiotechnology:integrated nanoparticle-biomolecule hybrid systems:synthesis,properties,and applications[J].Angewandte Chemie,International Edition,2004,43(45):6042-6108
[37]Hyeon T.,Lee S.S.,Park J.,Chung Y.,Na H.B.Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process[J].Journal of the American Chemical Society,2001,123(51):12798-12801.
[38]Guo Q.,Teng X.,Rahman S.,Yang H.Patterned Langmuir-Blodgett films of monodisperse nanoparticles of iron oxide using soft lithography[J].Journal of the American Chemical Society,2003,125(3):630-631.
[39]Lai J.-I.,Shaft Kurikka V.P.M.,Ulman A.,Loos K.,Lee Y.,Vogt T.,Lee W.-L.,Ong N.P.Controlling the size of magnetic nanoparticles using Pinronic block copolymer surfactants[J].Journal of Physical Chemistry B,2005,109(1):15-18.
[40]Sun S.,Zeng H.Size-controlled synthesis of magnetite nanoparticles[J].Journal of the American Chemical Society,2002,124(28):8204-8205.
[41]Sun S.,Zeng H.,Robinson D.B.,Raoux S.,Rice P.M.,Wang S.X.,Li G.Monodisperse MFe_2O_4(M=Fe,Co,Mn) Nanoparticles[J].Journal of the American Chemical Society,2004,126(1):273-279.
[42]Fried T.,Shemer G.,Markovich G.Ordered two-dimensional arrays of ferrite nanoparticles[J].Advanced Materials,2001,13(15):1158-1161.
[43]Kang Y.S.,Risbud S.,Rabolt J.F.,Stroeve P.Synthesis and Characterization of Nanometer-Size Fe_3O_4 and Fe_2O_3 Particles[J].Chemistry of Materials,1996,8(9):2209-2211.
[44]Hong C.-Y.,Jang I.J.,Horng H.E.,Hsu C.J.,Yao Y.D.,Yang H.C.Ordered structures in Fe_3O_4 kerosene-based ferrofluids[J].Journal of Applied Physics,1997,81(8,Pt.2A):4275-4277.
[45]Liao M.-H.,Chen D.-H.Preparation and characterization of a novel magnetic nano-adsorbent[J].Journal of Materials Chemistry,2002,12(12):3654-3659.
[46]Vaqueiro P.,Lopez-Quintela M.A.,Rivas J.Synthesis of yttrium iron garnet nanoparticles via coprecipitation in microemulsion[J].Journal of Materials Chemistry,1997,7(3):501-504.
[47]Shi J.,Verweij H.Synthesis and Purification of Oxide Nanoparticle dispersions by modified emulsion precipitation[J].Langmuir,2005,21(12):5570-5575.
[48]Zhou Z.H.,Wang J.,Liu X.,Chan H.S.O.Synthesis of Fe_3O_4 nanoparticles from emulsions[J].Journal of Materials Chemistry,2001,11(6):1704-1709.
[49]Vestal C.R.,Zhang Z.J.Synthesis and magnetic characterization of Mn and Co spinal ferrite-silica nanoparticles with tunable magnetic core[J].Nano Letters,2003,3(12):1739-1743.
[50]Santra S.,Tapec R.,Theodoropoulou N.,Dobson J.,Hebard A.,Tan W.Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion:the effect of nonionic surfactants[J].Langmuir,2001,17(10):2900-2906.
[51]Rondinone A.J.,Samia A.C.S.,Zhang Z.J.Superparamagnetic relaxation and magnetic anisotropy energy distribution in CoFe_2O_4 spinel ferrite nanocrystallites[J].Journal of Physical Chemistry B,1999,103(33):6876-6880.
[52]Tago T.,Hatsuta T.,Miyajima K.,Kishida M.,Tashiro S.,Wakabayashi K.Novel synthesis of silica-coated ferrite nanoparticles prepared using water-in-oil microemulsion[J].Journal of the American Ceramic Society,2002,85(9):2188-2194.
[53]Tartaj P.,Serna C.J.Synthesis of monodisperse superparamagnetic Fe/siliea nanospherical composites[J].Journal of the American Chemical Society,2003,125(51):15754-15755.[34]
[54]Vestal C.R.,Zhang Z.J.Synthesis and magnetic characterization of Mn and Co spinel ferrite-silica nanoparticles with tunable magnetic core[J].Nano Letters,2003,3(12):1739-1743.
[55]Lin Y.-S.,Wu S.-H.,Hung Y.,Chou Y.-H.,Chang C.,Lin M.-L.,Tsai C.-P.,Mou C.-Y.Multifunctional composite nanoparticles:magnetic,luminescent,and mesoporous[J].Chemistry of Materials,2006,18(22):5170-5172.
[56]Lu C.-W.,Hung Y.,Hsiao J.-K.,Yan M.,Chung T.-H.,Lin Y.-S.,Wu S.-H.,Hsu S.-C.,Liu H.-M.,Mou C.-Y.,Yang C.-S.,Huang D.-M.,Chen Y.-C.Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling[J].Nano Letters,2007,7(1):149-154.
[57]Kim J.,Lee J.E.,Lee J.,Yu J.H.,Kim B.C.,An K.,Hwang Y.,Shin C.-H.,Park J.-G.,Kim J.,Hyeon T.Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals[J].Journal of the American Chemical Society,2006,128(3):688-689.
[58]Yi D.K.,Selvan S.T.,Lee S.S.,Papaefthymiou G.C.,Kundaliya D.,Ying J.Y.Silica-coated nanocomposites of magnetic nanoparticles and quantum dots[J].Journal of the American Chemical Society,2005,127(14):4990-4991.
[59]Selvan S.T.,Patra P.K.,Ang C.Y.,Ying J.Y.Synthesis of silica-coated semiconductor and magnetic quantum dots and their use in the imaging of live cells[J].Angewandte Chemic,International Edition,2007,46(14):2448-2452.
[60]Santra S.,Tapec R.,Theodoropoulou N.,Dobson J.,Hebard A.,Tan W.Synthesis and characterization of silica-coated iron oxide nanoparticles in microemulsion:the effect of nonionic surfactants[J].Langmuir,2001,17(10):2900-2906.
[61]Deng Y.-H.,Wang C.-C.,Hu J.-H.,Yang W.-L.,Fu S.-K.Investigation of formation of silica-coated magnetite nanoparticles via sol-gel approach[J].Colloids and Surfaces,A:Physicochemical and Engineering Aspects,2005,262(1-3):87-93.
[62]Lu Y.,Yin Y.,Mayers B.T.,Xia Y.Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol-gel approach[J].Nano Letters,2002,2(3):183-186.
[63]Zhao W.,Gu J.,Zhang L.,Chen H.,Shi J.Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure[J].Journal of the American Chemical Society,2005,127(25):8916-8917.
[64]Tovmachenko O.G.,Graf C.,van den Heuvel D.J.,van Blaaderen A.,Gerritsen H.C.Fluorescence enhancement by metal-core/silica-shell nanoparticles[J].Advanced Materials,2006,18(1):91-95.
[65]Liz-Marzan L.M.,Giersig M.,Mulvaney P.Synthesis of nanosized gold-silica core-shell particles[J].Langmuir,1996,12(18):4329-4335.
[66]Ohmori M,Matijevic E.Preparation and properties of uniform coated colloidal particles [J].Journal of Colloid and Interface Science,1992,150(2):594-598.
[67]Salgueirino-Maceira V.,Correa-Duarte M.A.,Spasova M.,Liz-Marzan L.M.,Farle M.Composite silica spheres with magnetic and luminescent functionalities[J].Advanced Functional Materials,2006,16(4):509-514.
[68]Chen M.,Gao L.,Yang S.,Sun J.Fabrication of well-defined water-soluble core/shell heteronanostructures through the SiO_2 spacer[J].Chemical Communications,2007,(12):1272-1274.
[69]Xu C.,Xu K.,Gu H.,Zheng R.,Liu H.,Zhang X.,Guo Z.,Xu B.Dopamine as a robust anchor to immobilize functional molecules on the iron oxide shell of magnetic nanoparticles[J].Journal of the American Chemical Society,2004,126(32):9938-9939.
[70]Gu H.,Xu K.,Xu C.,Xu B.Biofunctional magnetic nanoparticles for protein separation and pathogen detection[J].Chemical Communications,2006,(9):941-949.
[71]Zhao X.,Tapec-Dytioco R.,Wang K.,Tan W.Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers[J].Analytical Chemistry,2003,75(14):3476-3483.
[72]Widder K.J.,Senyei Andrew E.,Scarpelli D.G.Magnetic microspheres:a model system for site specific drug delivery in vivo[J].Proceedings of the Society for Experimental Biology and Medicine,1978,158(2):141-146.
[73]Song H.-T.,Choi J.-S.,Huh Y.-M.,Kim S.,Jun Y.-W.,Suh J.-S.,Cheon J.Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling[J].Journal of the American Chemical Society,2005,127(28):9992-9993.
[74]Weissleder R.,Moore A.,Mahmood U.,Bhorade R.,Benveniste H.,Chiocca E.A.,Basilion J.P.In vivo magnetic resonance imaging of transgene expression[J].Nature Medicine,2000,6(3):351-354.
[75]Zhao M.,Beauregard D.A.,Loizou L.,Davletov B.,Brindle K.M.Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent[J].Nature Medicine,2001,7(11):1241-1244.
[76]Lee J.-H.,Jun Y.-W.,Yeon S.-I.,Shin J.-S.,Cheon J.Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma[J].Angewandte Chemie,International Edition,2006,45(48):8160-8162.
[77]Corr S.A.,Rakovich Y.P.,Gun'ko Y.K.Multifunctional magnetic-fluorescent nanocomposites for biomedical appfications[J].Nanoscale Research Letters,2008,3(3):87-104.
[78]Du G.H.,LiuZ.L.,Lu Q.H.,Xia X.,Jia L.H.,Yao K.L.,Chu Q.,Zhang S.M.Fe_3O_4/CdSe/ZnS magnetic fluorescent bifunctional nanocomposites[J].Nanotechnology,2006,17(12):2850-2854.
[79]Salgueirino-Maceira V.,Correa-Duarte M.A.,Spasova M.,Liz-Marzan L.M.,Farle M.Composite silica spheres with magnetic and luminescent functionalities[J].Advanced Functional Materials,2006,16(4):509-514.
[80]Lin Y.S.,Wu S.H.,Hung Y.,Chou Y.H.,Chang C.,Lin M.L.,Tsai C.P.,Mou C.Y.Multifunctional composite nanoparticles:magnetic,luminescent,and mesoporous[J].Chemistry of Materials,2006,18(22):5170-5172.
[81]Yi D.K.,Selvan S.T.,Lee S.S.,Papaefthymiou G.C.,Kundaliya D.,Ying J.Y.Silica-coated nanocomposites of magnetic nanoparticles and quantum dots[J].Journal of the American Chemical Society,2005,127(14):4990-4991.
[82]Mulder W.J.,Griffioen A.W.,Strijkers G.J.,Cormode D.P.,Nicolay K.,Fayad Z.A.Magnetic and fluorescent nanopatieles for multimodality imaging[J].Nanomedicine,2007,2(3):307-324.
[83]Zhang Y.,Wang S.N.,Ma S.,Guan J.J.,Li D.,Zhang X.D.,Zhang Z.D.Self-assembly multifunctional nanocomposites with Fe_3O_4 magnetic core and CdSe/ZnS quantum dots shell[J].Journal of Biomedical Materials Research,Part A,2008,85(3):840-846.
[84]Lu H.,Yi G.,Zhao S.,Chen D.,Guo L.,Cheng J.Synthesis and characterization of multi-functional nanoparticles possessing magnetic,up-conversion fluorescence and bio-affinity properties[J].Journal of Materials Chemistry,2004,14(8):1336-1341.
[85]Abu-Reziq R.,Alper H.,Wang D.,Post M.L.Metal supported on dendronized magnetic nanoparticles:highly selective hydroformylation catalysts[J].Journal of the American Chemical Society,2006,128(15):5279-5282.
[86]Ding S.,Xing Y.,Radosz M.,Shen Y.Magnetic nanoparticles supported catalyst for transfer radical polymerization[J].Macromolecules,2006,39(19):6399-6405.
[87]Chen D.H.,Liao M.H.Preparation and characterization of YADH-bound magnetic nanoparticles[J].Journal of Molecular Catalysis B:Enzymatic,2002,16(5-6):283-291.
[88]Tsang S.C.,Yu C.H.,Gao X.,Tam K.Silica-encapsulated nanomagnetic particles as a new recoverable biocatalyst carrier[J].Journal of Physical Chemistry B,2006,110(34):16914-16922.
[89]Yi D.K.,Lee S.S.,Ying J.Y.Synthesis and application of magnetic nanocomposite catalysts[J].Chemistry of Materials,2006,18(10):2459-2461.
[90]Chen X.,Zhao T.,Zou J.,A Novel Mimetic Peroxidase Catalyst by Using Magnetite-Containing Silica Nanoparticles as Carriers[J],Microchimica Acta,2008,(in press).
[91]Lyon J.L.,Fleming D.A.,Stone M.B.,Schiffer P.,Williams M.E.Synthesis of Fe oxide core/Au shell nanoparticles by iterative hydroxylamine seeding[J].Nano Letters,2004,4(4):719-723.
[92]Gmucova K,Weis M,Nadazdy V,Majkova E.Orientation ordering of nanoparticle Ag/Co cores controlled by electric and magnetic fields[J].ChemPhyChem,2008,9(7):1036-1039.
[93]Han X.,Wang Y.S.Studies on the synthesis and microwave absorption properties of Fe_3O_4/polyaniline FGM[J].Physica Scripta,2007,T129:335-339.
[94]de Oliveira H.P.,Andrade C.A.S.,de Melo C.P.Electrical impedance spectroscopy investigation of surfactant-magnetite-polypyrrole particles[J].Journal of Colloid and Interface Science.2008,319(2):441-449.
[95]Aphesteguy J.C.,Jacobo S.E.Synthesis of a soluble polyaniline-ferrite composite:magnetic and electric properties[J].Journal of Materials Science.2007,42(17):7062-7068.
[96]Koo Y.S.,Kim D.H.,Jung J.H.Synthesis of electric/magnetic oxide core/shell nanoparticles and their characteristics[J].Journal of the Korean Physical Society.2006,48(4):677-680.
[97]Okumura M.,Nakamara S.,Tsubota S.,Nakamura T.,Azuma M.,Chemical vapor deposition of gold on Al_2O_3,SiO_2,and TiO_2 for the oxidation of CO and of H_2[J]Catalysis Letters,1998,51(1,2),53-58.
[98]Okumura M.,Akita T.,Haruta M.,Hydrogenation of 1,3-butadiene and of crotonaldehyde over highly dispersed Au catalysts[J].Catalysis Today,2002,74(3-4):265-269.
[99]Mohr C.,Hofmeister H.,Claus P.The influence of real structure of gold catalysts in the partial hydrogenation of acrolein[J].Journal of Catalysis,2003,213(1):86-94.
[100]Porta F.,Prati L.,Rossi M.,Collucia S.,Martra G.Metal sols as a useful tool for heterogeneous gold catalyst preparation:reinvestigation of a liquid phase oxidation[J].Catalysis Today,2000,61(1-4):165 - 172.
[101]Landon P.,Collier P.J.,Papworth A.J.,Kiely C.J.,Hutchings G.J.Direct formation of hydrogen peroxide from H_2/O_2 using a gold catalyst[J].Chemical Communications,2002,(18):2058-2059.
[102]Shi F.,Deng Y.Polymer-Immobilized Gold Catalysts for the Efficient and Clean Syntheses of Carbamates and Symmetrical Ureas by Oxidative Carbonylation of Aniline and Its Derivatives[J].Journal of Catalysis,2002,211(2):548-551.
[103]Kim S.-W.,Son S.U.,Lee S.S.,Hyeon T.,Chung Y.K.Colloidal cobalt nanoparticles:a highly active and reusable Pauson-Khand catalyst[J].Chemical Communications,2001,(23):2212-2213.
[104]Pedersen C.J.The discovery of crown ethers[J].Angewandte Chemie,1988,100(8):1053-1059.
[105]Lehn J.M.Supramolecular chemistry-scope and perspectives molecules,supermolecules,and molecular devices[J].Angewandte Chemie,International Edition,1988,27(1):89-112.
[106]Cram D.J.The design of molecular hosts,guests,and their complexes[J].Angewandte Chemie,International Edition,1988,27(8):1009-1020.
[107]高鸿 分析化学前沿[M].科学出版社,北京,1991.
[108]de Silva A.P.,Gunaratne H.Q.N.,Gunnlaugsson T.,Huxley A.J.M.,McCoy C.P.,Rademacher J.T.,Rice T.E.Signaling recognition events with fluorescent sensors and switches[J].Chemical Reviews,1997,97(5):1515-1566.
[109]江云宝 氢键介导的分子识别与荧光传感,分析化学的明天[M].科学出版社,北京,2003.
[110]Wu S.Some photo-chemical and photo-physical problems in fluorescent chemical sensor study[J].Progress in Chemistry,2004,16(2):174-183.
[111]Lee S.J.,Lee S.S.,Lee J.Y.,Jung H.J.A functionalized inorganic nanotube for the selective detection of copper(Ⅱ) ion[J].Chemistry of Materials,2006,18(20):4713-4715.
[112]Lee S.J.,Lee S.S.,Lah M.S.,Hong J.-M.,Jung J.H.Organic-inorganic hybrid nanomaterial as a new fluorescent chemosensor and adsorbent for copper ion[J].Chemical Communications,2006,(43):4539-4541.
[113]Atia A.A.Studies on the interaction of mercury(Ⅱ) and uranyl(Ⅱ) with modified chitosan resins[J].Hydrometallurgy,2005,80(1-2):13-22.
[114]Palomares E.,Vilar R.,Durrant J.R.Heterogeneous colorimetric sensor for mercuric salts[J].Chemical Communications,2004,(4):362-363.
[1]Martin C.R.,Mitchell D.T.Nanomaterials in analytical chemistry[J].Analytical Chemistry,1998,70(9):322A-327A.
[2]Paull R.,Wolfe J.,Hebert P.,Sinkula M.Investing in nanotechnology[J].Nature Biotechnology,2003,21(10):1144-1147.
[3]Whitesides G.M.The 'right' size in nanobiotechnology[J].Nature Biotechnology,2003,21(10):1161-1165.
[4]Zhu Q.Z.,Li Q.G.,Lu J.Z.,Xu J.G.Application of thiamine as a fluorogenic substrate in the determination of hydrogen peroxide based on the catalytic effect of hemin[J].Analytical Letters,1996,29(10):1729-1740.
[5]Zhang G.F.,Dasgupta P.K.Hematin as a peroxidase substitute hi hydrogen peroxide determinations[J].Analytical Chemistry,1992,64(5):517-522.
[6]Chen Q.Y.,Li D.H.,Zhu Q.Z.,Zheng H.,Xu J.G.Application of iron-tetrasulfonatophthalocyanine as a newmimetic peroxidase in the determination of hydrogen peroxide with p-hydroxyphenylpropionic acid as a substrate[J].Analytica Chimica Acta,1999,381(2-3):175-182.
[7]Zhu Q.Z.,Yang H.H.,Li D.H.,Chen Q.Y.,Xu J.G.A novel mimetic enzymatic fluorescence immunoassay for hepatitis B surface antigen by using a thermal phase separating polymer[J].Analyst,2000,125(12):2260-2263.
[8]Chen L.H.,Liu L.Z.,Shen H.X.Mn(Ⅱ)- sodium dodecyl sulphate complex mimic enzyme-catalyzed fluorescence quenching of Pyronine B by hydrogen peroxide[J].Analytica Chimica Acta,2003,480(1):143-150.
[9]Yang H.H.,Zhu Q.Z.,Chen Q.Y.,Xu J.G.,Li D.H.Temperature modulated solubility and activity alteration for oligo-(N-isopropylacrylamide)-iron tetrasulfonatophthalocyanine conjugates as a new mimetic peroxidase[J].Analyst,2000,125(4):719-724.
[10]Mesu J.G.,Baute D.,Tromp H.J.,Faassen E.E.,Weckhuysen B.M.Synthesis and characterization of zeolite encaged enzymemimetic copper histidine complexes[J].Studies in Surf ace Science and Catalysis,2002,143:287-293.
[11]Yang W.,Zheng H.,Yuan W.T.,Xu J.G.Silica-hemin composite nanoparticles as new biocatalyst to highly sensitive determination of glucose in human serum[J].Analytical Sciences,2004,20(9):1265-1270.
[12]Zou J.L.,Chen X.L.Silica nanoparticles as catalyst carriers to the highly sensitive determination of thiamine[J].Microchemical Journal,2007,86(1):42-47.
[13]Nomura A.,Shin S.,Mehdi O.O.,Kauffmann J.M.Preparation,characterization,and application of an enzyme-immobilized magnetic microreactor for flow injection analysis [J].Analytical Chemistry,2004,76(18):5498-5502.
[14]Yoon T.J.,Kim J.S.,Kim B.G.,Yu K.N.,Cho M.H.,Lee J.K.Multifunctional nanoparticles possessing a "Magnetic Motor Effect" for drug or gene delivery[J].Angewandte Chemie,International Edition,2005,44(7):1068-1071.
[15]Goetz V.,Remaud M.,Graves D.J.A novel magnetic silica support for use in chromatographic and enzymic bioprocessing[J].Biotechnology and Bioengineering,1991,37(7):614-626.
[16]del Campo A.,Sen T.,Lellouche J.P.,Bruce I.J.Multifunctional magnetite and silica- magnetite nanoparticles:synthesis,surface activation and applications in life sciences [J].Journal of Magnetism and Magnetic Materials,2005,293(1):33-40.
[17]He Y.P.,Wang S.Q.,Li C.R.,Miao Y.M.,Wu Z.Y.,Zou B.S.Synthesis and characterization of functionalized silica-coated Fe_3O_4 superparamagnetic nanocrystals for biological applications[J].Journal of Physics D:Applied Physics,2005,38(9):1342-1350.
[18]Ashtari P.,He X.X.,Wang K.M.,Gong P.An efficient method for recovery of target ssDNA based on amino-modified silicacoated magnetic nanoparticles[J].Talanta,2005,67(3):548-554.
[19]Yu D.H.,Blankert B.,Bodoki E.,Bollo S.,Vire J.C.,Sandulescu R.,Nomuraa A.,Kauffmann J.M.Amperometric biosensor based on horseradish peroxidase-immobilised magnetic microparticles[J].Sensors and Actuators,B:Chemical,2006,113(2):749-754.
[20]Butterworth M.D.,Illum L.,Davis S.S.Preparation of ultrafine silica- and PEG-coated magnetite particles[J].Colloids and Surfaces,A:Physicochemical and Engineering Aspects,2001,179(1):93-102.
[21]Szabo D.V.,Vollath D.Nanocomposites from coated nanoparticles[J].Advanced Materials,1999,11(15):1313-1316.
[22]Van Zoonen P.,Kamminga D.A.,Gooijer C.,Velthorst N.H.,Frei R.W.Flow injection determination of hydrogen peroxide by means of a solid-state-peroxyoxalate chemiluminescence reactor[J].Analytica Chimica Acta,1985,167:249-256.
[23]Ishida J.,Arakawa H.,Takada M.,Yamaguchi M.Development of a novel luminol-related compound,3-propyl-7,8-dihydropyridazino-[4,5-g]quinoxaline-2,6,9(1H)-trione,and its application to hydrogen peroxide and serum glucose assays[J].Analyst,1995,120(4):1083-1086.
[24]Marie L.,Greenway G.M.Determination of hydrogen peroxide in rainwater in a miniaturised analytical system[J].Analytica Chimica Acta,2005,548(1-2):20-25.
[25]Yang L.,Janle E.,Huang T.H.,Gitzen J.,Kissinger P.T.,Vreeke M.,Heller A.Applications of "wired" peroxidase electrodes for peroxide determination in liquid chromatography coupled to oxidase immobilized enzyme reactors[J].Analytical Chemistry,1995,67(8):1326-1331.
[26]Park T.M.Amperometric determination of hydrogen peroxide by utilizing a sol-gel-derived biosensor incorporating an osmium redox polymer as mediator[J].Analytical Letters,1999,32(2):287-298.
[27]Gundogan-Paul M.,Ozyoruk H.,Celebi S.S.,Yildiz A.Amperometric enzyme electrode for hydrogen peroxide determination prepared with horseradish peroxidase immobilized in polyvinylferrocenium(PVFt)[J].Electroanalysis,2002,14(7-8):505-511.
[28]Johnson K.S.,Sakamoto-Arnold C.M.,Willason S.W.,Beehler C.L.Reagent-injection flow analysis:application to the determination of nanomolar levels of hydrogen peroxide in seawater[J].Analytica Chimica Acta,1987,201:83-94.
[29]Almuaibed A.M.,Townshend A.Flow spectrophotometric method for determination of hydrogen peroxide using a cation exchanger for preconcentration[J].Analytica Chimica Acta,1994,295(1-2):159-163.
[30]Yuan H.,Cai R.X.,Pan Z.T.Catalytical kinetic determination of hydrogen peroxide using iron-tetrasulfonatophthalocyanine(with gamma-CD) as a mimetic enzyme of peroxidase[J].Analytical Letters,2003,36(2):277-286.
[31]Hwang H.,Dasgupta P.K.Fluorometric flow injection determination of aqueous peroxides at nanomolar level using membrane reactors[J].Analytical Chemistry,1986,58(7):1521-1524.
[32]Tanner R.L.,Markovits G.Y.,Ferreri E.M.,Kelly T.J.Sampling and determination of gas-phase hydrogen peroxide following removal of ozone by gas-phase reaction with nitric oxide[J].Analytical Chemistry,1986,58(8):1857-1865.
[33]Miller W.L.,Kester D.R.Hydrogen peroxide measurement in seawater by (p-hydroxyphenyl)acetic acid dimerization[J].Analytical Chemistry,1985,60(24):2711-2715.
[34]Li Y.Z.,Townshend A.Evaluation of the adsorptive immobilisation of horseradish peroxidase on PTFE tubing in flow systems for hydrogen peroxide determination using fluorescence detection[J].Analytica Chimica Acta,1998,359(1-2):149-156.
[35]Chen X.L.,Li D.H.,Yang H.H.,Zhu Q.Z.,Zheng H.,Xu J.G.Study of tetra-substituted amino aluminum phthalocyanine as a new red-region substrate for the fluorometric determination of peroxidase and hydrogen peroxide[J].Analytica Chimica Acta,2001,434(1):51-58.
[36]Tang B.,Wang Y.,Sun Y.,Shen H.X.Spectrofluorimetric determination of hydrogen peroxide with 2-hydroxy-1-naphthaldehyde salicyloylhydrazone(HNSH) as the substrate for horseradish peroxidase(HRP)[J].Spectrochimica Acta.Part A,Molecular and Biomolecular Spectroscopy,2002,58(1):141-148.
[37]Kang Y.S.,Risbud S.,Rabolt J.F.,Stroeve P.synthesis and characterization of nanometer-size Fe_3O_4 and γ-Fe_2O_3 particles[J].Chemistry of Materials,1996,8(9):2209-2211.
[38]Stober W.,Fink A.Controlled growth of monodisperse silica spheres in the micron size Range[J].Journal of Colloid and Interface Science,1968,26(1):62-69.
[39]Chang S.Y.,Liu L.,Asher S.A.Creation of templated topological morphologies in colloidal silica[J],Journal of the American Chemical Society,1994,116(15):6745-6747.
[40]Arriagada F.J.,Osseo-Asare K.Synthesis of nanosize silica in a nonionic water-in-oil microemulsion:efffects of the water/surfactant molar ratio and ammonia concentration [J],Journal of Colloid and Interface Science,1999,211(2):210-220.
[41]Van Blasderen A.,Vrij A.Synthesis and characterization of colloidal dispersions of fluorescent,monodisperse silica spheres[J],Langmuir,1992,8(12):2921-2931.
[42]Yin D.K.,Selvan S.T.,Lee S.S.,Papaefthymiou G.C.,Kundaliya D.,Ying J.Y.Silica-coated nanocomposites of magnetic nanoparticles and quantum dots[J],Journal of the American Chemical Society,2005,127(14):4990-4991.
[43]Nimesha S.,Manchandac R.,Kumara R.,Saxena A.,Chaudhary P.,Yadav V.,Mozumdar S.,Chandra R.Preparation,characterization and in vitro drug release studies of novel polymeric nanoparticles[J],International Journal of Pharmaceutics,2006,323(1-2):146-152.
[44]Saxena A.,Sachin K.,Bohidar H.B.,Verma A.K.Effect of molecular weight heterogeneity on drug encapsulation efficiency of gelatin nano-particles[J],Colloids and Surfaces,B:Biointerfaces,2005,45(1):42-48.
[45]Santra S.,Zhang P.,Wang K.,Tapec R.,Tan W.Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers[J].Analytical Chemistry,2001,73(20):4988-4993.
[46]Ow H.,Larson D.R.,Srivastava M.,Baird B.A.,Webb W.W.,Wiesner U.Bright and stable core-shell fluorescent silica nanoparticles.Nano Letters,2005,5(1):113-117.
[47]Bele M.,Siiman O.,Matijevic E.Preparation and flow cytometry of uniform silica-fluorescent dye microspheres[J].Journal of Colloid and Interface Science,2002,254(2):274-282.
[48]Heule M.,Rezwan K.,Cavalli L.,Gauckler L.J.A miniaturized enzyme reactor based on hierarchically shaped porous ceramic microstruts[J].Advanced Materials,2003,15(14):1191-1194.
[49]Briggs G.E.,Haldane J.B.S.Note on the kinetics of enzyme action[J].Biochemical Journal,1925,19(6):338-339.
[50]Lineweaver H.,Burk D.Determination of enzyme dissociation constants[J].Journal of the American Chemical Society,1934,56:658-666.
[1]Zhu C.Q.,Zhuo S.J.,Chen J.L.,Wu Y.Q.,Li Y.X.,Li D.H.,Zheng H.,Xu J.G.A kinetic fluorometric method for the determination of nucleic acids using a ternary equilibrium system of nucleic acids-iron(Ⅲ) tetracarboxy phthalocyanine-poly-lysine coupled with the oxidation reaction between hydrogen peroxide and DL-tyrosine[J].Analytica Chimica Acta,2004,514(2):247-252.
[2]Chen L.H.,Liu L.Z.,Shen H.X.Studies on mimic peroxidase behaviors of molybdenum(Ⅵ)-sodium dodecyl sulphate complex for the determination of hydrogen peroxide and glucose[J].Analytical Letters,2004,37(4):561-573.
[3]Chen L.H.,Liu L.Z.,Shen H.X.Mn(Ⅱ)-sodium dodecyl sulphate complex mimic enzyme-catalyzed fluorescence quenching of Pyronine B by hydrogen peroxide[J].Analytica Chimica Acta,2003,480(1):143-150.
[4]Chen Q.Y.,Li D.H.,Zhu Q.Z.,Yang H.H.,Zheng H.,Xu J.G.Investigation on the potential use of the mimetic peroxidase-catalyzed reaction of hydrogen peroxide and o-hydroxyphenylfluorone in fluorescence analysis[J].Analytica Chimica Acta,2000,406(2):209-215.
[5]Chen M.,Cai W.P.,Zhu Q.Z.,Wang X.S.,Xu J.G.Determination of glucose based on the effect of photons as a substitute for glucose oxidase[J].Analytica Chimica Acta,1999,388(1-2):11-17.
[6]Zhu Q.Z.,Zheng X.Y.,Xu J.G..Application of hemin as a labeling reagent in mimetic enzyme immunoassay for hepatitis B surface antigen[J].Analytical Letters,1998,31(6):963-971.
[7]Zhu Q.Z.,Liu F.H.,Xu J.G.,Su W.J.,Huang J.W.Mimetic-enzyme fluorescence immunoassay using a thermal phase separating polymer[J].Analyst,1998,123(5):1131-1134.
[8]Robinson P.J.,Dunnill P.,Lilly M.D.Properties of magnetic supports in relation to immobilized enzyme reactors[J].Biotechnology and Bioengineering,1973,15(3):603-606.
[9]Zhao X.,Tapec-Dytioco R.,Wang K.,Tang W.Collection of trace amounts of DNA/mRNA molecules using genomagnetic nanocapturers[J].Analytical Chemistry,2003,75(14):3476-3483.
[10]Guo J.,Yang W.,Wang C.,He J.,Chen J.Poly(N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres:preparation,characterization,and biomedical applications[J].Chemistry of Materials,2006,18(23):5554-5562.
[11]Fernandez-Pacheco R.,Arruebo M.,Marquina C.,Ibarra R.,Arbiol J.,Santamaria J.Highly magnetic silica-coated iron nanoparticles prepared by the arc-discharge method[J].Nanotechnology,2006,17(5):1188-1192.
[12]Yoon T.J.,Yu K.N.,Kim E.,Kim J.S.,Kim B.G.,Yun S.H.,Sohn B.H.,Cho M.H.,Lee J.K.,Park S.B.Specific targeting,cell sorting,and bioimaging with smart magnetic silica core-shell nanomaterials[J].Small,2006,2(2):209-215.
[13]Tan W.,Wang K.,He X.,Zhao X.J.,Drake T.,Wang L.,Bagwe R.P.Bionanotechnology based on silica nanoparticles[J].Medicinal Research Reviews,2004,24(5):621-638.
[14]Fried T.,Shemer G.,Markovich G.Ordered two-dimensional arrays of ferrite nanoparticles[J].Advanced Materials,2001,13(15):1158-1161.
[15]Wang L,Bao J.,Wang L.,Zhang F.,Li Y.One-pot synthesis and bioapplicaiton of amine-functionalized magnetite nanoparticles and hollow nanospheres[J].Chemistry-A European Journal,2006,12(24):6341-6347.
[16]Kang Y.S.,Risbud S.,Rabolt J.F.,Stroeve P.Synthesis and characterization of nanometer-size Fe_3O_4 and γ-Fe_2O_3 particles[J].Chemistry of Materials,1996,8(9):2209-2211.
[17]Liu S.,Zhang H.L.,Liu T.C.,Liu B.,Cao Y.C.,Huang Z.L.,Zhao Y.D.,Luo Q.M.Optimization of the methods for introduction of amine groups onto the nanoparticles surface[J].Journal of Biomedical Materials Research,Part A,2007,80(3):752-757.
[18]Bagwe R.P.,Hilliard L.R.,Tang W.Surface modification of silica nanoparticles to reduce aggregation and nonspecific binding[J].Langmuir,2006,22(9):4357-4362.
[19]Barnakov Y.A.,Yu M.H.,Rosenzweig Z.Manipulation of the magnetic properties of magnetite-silica nanocomposite materials by controlled Stober synthesis[J].Langmuir,2005,21(16):7524-7527.
[20]Taylor I.,Howard A.G.Measurement of primary amine groups on surface-modified silica and their role in metal binding[J].Analytica Chimica Acta,1992,271(1):77-82.
[21]Heule M.,Rezwan K.,Cavalli L.,Ganckler L.J.A miniaturized enzyme reactor based on hierarchically shaped porous ceramic microstruts[J].Advanced Materials,2003,15(14):1191-1194.
[22]Li X.Z.,Wan L.,Zhou C.,Guan T.T.,Li J.,Zhang Y.H.Preliminary studies of application of CdTe nanocrystals and dextran-Fe_3O_4 magnetic nanoparticles in sandwich immunoassay[J].Clinica Chimica Acta,2007,378(1-2):168-174.
[23]Ribone M.E.,Belluzo M.S.,Pagani D.,Macipar I.S.,Lagier C.M.Amperometric bioelectrode for specific human immunoglobulin G determination:Optimization of the method to diagnose American trypanosomiasis[J].Analytical Biochemistry,2006,350(1):61-70.
[24]Zhao H.W.,Huang C.Z.,Li Y.F,.Immunoassay by detecting enhanced resonance light scattering signals of immunocomplex using a common spectrofluorometer[J].Talanta,2006,70(3):609-614.
[25]林学颜 免疫学基础[M].福建科学技术出版社,福建,1980.
[1]Holla B.S.,Kalluraya B.,Sridhar K.R.,Drake E.,Thomas L.M.,Bhandary K.K.,Levine M.J.Synthesis,structural characterization,crystallographic analysis and antibacterial properties of some nitrofuryl triazolo[3,4-b]-1,3,4-thiadiazines[J].European Journal of Medicinal Chemistry,1994,29(4):301-308.
[2]Demirayak S.,Benkli K.,Guven K.Synthesis and antimicrobial activities of some 3-arylamino-5-[2-(substituted 1-imidazolyl)ethyl]-1,2,4-triazole derivatives[J].European Journal of Medicinal Chemistry,2000,35(11):1037-1040.
[3]Liu F.M.,Wang B.L.,Lu W.J.Synthesis of trifluoromethyl-substituted 1,2,4-triazole mannich bases[J].Chinese Journal of Organic Chemistry,2000,20(5):738-742.
[4]Mishra P.,Gupta P.N.,Shakya A K.Synthesis of some Schiff bases of 3-amino-2-methyiquinazolin-4(3H)-ones and their antimicrobial activities[J].Journal of the Indian Chemical Society,1991,68(11):618-619.
[5]Srivastava S.K.,Pathak R.B.,Babel S.C.Synthesis of schiff base,2,5-disubstituted-1,3,4-oxadiazoles and 2,3-disubstituted-4-thiazolidinones as antifungal agents[J].Journal of the Indian Chemical Society,1991,68(2):113-114.
[6]Li G.,Zhang D.Determining silver accurately by method of sodium chloride deposit-residue potential titration[J].Precious Metals,2005,26(4):27-30.
[7]Wang X.Determination of Cu,Ag,As in lead and lead alloys by ICP-AES[J].Chemical Analysis and Meterage,2005,14(6):22-24.
[8]Lee S.J.,Lee S.S.,Lee J.Y.,Jung H.J.A functionalized inorganic nanotube for the selective detection of copper(Ⅱ) ion[J].Chemistry of Materials,2006,18(20):4713-4715.
[9]Lee S.J.,Lee S.S.,Lah M.S.,Hong J.-M.,Jung J.H.Organic-inorganic hybrid nanomaterial as a new fluorescent chemosensor and adsorbent for copper ion[J].Chemical Communications,2006,(43):4539-4541.
[10]Kim T.H.,Jung J.H.,Choi J.K.,Choi Y.H.,Lee S.J.,Seo M.L.,Kim J.S.Fluorescent calix[4]arene-appended silica nanotubes as selective chemosensor and adsorbent for Pb~(2+)ion[J].Chemistry Letters,2007,36(3):360-361.
[11]Atia A.A.Studies on the interaction of mercury(Ⅱ) and uranyl(Ⅱ) with modified chitosan resins[J].Hydrometallurgy,2005,80(1-2):13-22.
[12]Palomares E.,Vilar R.,Durrant J.R.Heterogeneous colorimetric sensor for mercuric salts[J].Chemical Communications,2004,(4):362-363.
[13]Nath M.,Sulaxna,Song X.,Eng G.Organotin(Ⅳ) triazolates:synthesis and their spectral characterization[J].Journal of Organometallic Chemistry,2006,691(8):1649-1657.
[14]Koparir M.,Cetin A.,Cansiz A.5-Furan-2yl[1,3,4]oxadiazole-2-thlol,5-furan-2yl-4H[1,2,4]triazole-3-thiol and their thiol-thione tautomerism[J].Molecules,2005,10(2):475-480.
[15]E1-Kemary M.A.,E1-Khouly M.E.,Ito O.Photophysical characteristics of two 4,6-disubistituted-3-cyanopyridin-2(1H)-thiones in various solvents[J].Journal of Photochemistry and Photobiology A:Chemistry,2000,137(2-3):105-113.
[16]Martos-Calvente R.,de la Pena O'Shea V.A.,Campos-Martin J.M.,Fierro J.L.G.The usefulness of density functional theory to describe the tautomeric equilibrium of 4,6-dimethyl-2-mercaptopyrimidine in solution[J].Journal of Physical Chemistry A,2003,107(38):7490-7495.