小鼠着床位点基因表达系列分析
摘要
胚胎着床涉及胚胎和子宫之间一系列复杂的相互作用,许多基因参与其中。尽管已利用寡核苷酸芯片、cDNA芯片、DDRT-PCR等各种不同的技术筛选到一些着床相关基因,但胚胎着床的机制仍不清楚。为了全面了解胚胎着床相关分子和发现新的胚胎着床相关信号通路,我们首次应用基因表达系列分析(SAGE)技术,分析了小鼠早期妊娠第五天非着床位点和着床位点子宫的基因表达谱。
我们利用早期妊娠小鼠第五天的子宫分别构建了非着床位点和着床位点标签长10 bp的两个SAGE文库,非着床位点测序的标签数为51306个,对应16964个特异标签,着床位点测序的标签数为53214个,对应16733个特异的标签。为了提高SAGE库中标签对应基因的比例,我们利用同一个SAGE文库的序列文件,构建了标签长11 bp的两个文库,非着床位点的标签总数为48121,对应16677个特异标签,着床位点的标签总数为50227,对应16696个特异的标签。共有1039个标签在非着床位点特异性表达,1252个标签在着床位点特异性表达。根据p值,195个标签在非着床位点显著上调,其中100个标签是单一匹配的,261个标签在着床位点显著上调,其中127个是单一匹配的。
为了验证SAGE结果的可信性,我们随机选取14个单一匹配的标签对应的基因(其中7个在着床位点上调,7个下调)进行RT-PCR验证,所有这些基因的RT-PCR结果与SAGE结果中的表达趋势一致。我们利用原位杂交对SAGE结果也进行了验证。与非着床位点相比,1810014L12Rik、Psmb5、Cd63、Npm1、Fads3和Tagln2在着床位点处的腔上皮下基质细胞中高表达。Ddx39在第5天着床位点腔上皮下基质中强表达,在非着床位点及假孕第5天未检测到杂交信号。利用假孕及延迟着床模型发现,Ddx39的表达受正在着床的活性胚泡的诱导。在卵巢切除的小鼠中,Ddx39的表达受雌激素显著上调,孕酮对Ddx39的表达没有明显影响。这表明Ddx39可能在胚胎着床过程中发挥重要作用。
总之,我们成功地构建了早期妊娠小鼠第5天子宫的非着床位点和着床位点两个SAGE文库,筛选得到了一批与胚胎着床相关的基因,为进一步研究胚胎着床的分子机理提供了大量有价值的信息。
Implantation is a complex interaction between the uterus and blastocyst. A lot of genes are imvolved in embryo-uterine interactions during implantation. Oligonucleotide chips, cDNA microarrays, differential display RT-PCR and other approaches have been used to screen implantation-related molecules. To identify implantation-related genes and novel pathways during implantation, the differential gene expression between inter-implantation site and implantation site in mouse uterus on day 5 of pregnancy was profiled by serial analysis of gene expression (SAGE). The SAGE libraries of 10 bp tags constructed from mouse uteri at inter-implantation site and implantation site were deposited in the GEO repository. The total numbers of tags sequenced were 51,306 tags for inter-implantation library and 53,214 tags for implantation library, corresponding to 16,964 and 16,733 unique tags, respectively. In order to increase the percentage of the tags with single match, we also used the same sequence files of SAGE libraries to construct two SAGE libraries of 11-bp tags. The total numbers of tags in 11-bp libraries were 48,121 for inter-implantation site and 50,227 for implantation site, corresponding to 16,677 and 16,696 unique tags, respectively. There were 1,039 tags specifically expressed at inter-implantation site, and 1,252 tags specifically expressed at implantation site. Based on p-value, there were 195 tags significantly up-regulated at inter-implantation site and 261 tags significantly up-regulated at implantation site, of which 100 genes were single-matched at inter-implantation site and 127 genes single-matched at implantation site, respectively.
In order to validate SAGE data, RT-PCR was performed to examine differential expression of 14 randomly selected tags with single match, 7 for significantly up-regulated ones and 7 for down-regulated ones. For all of the genes examined, the trend of relative expression of their transcripts was comparable between SAGE and RT-PCR. SAGE data were further confirmed by in situ hybridization. 1810014L12Rik, Psmb5, Cd63, Npm1, Fads3 and Tagln2 were shown to be highly expressed at implantation site compared to inter-implantation site. Compared to inter-implantation site, Ddx39 was strongly expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. Ddx39 expression at implantation site was specifically induced by active blastocysts. Additionally, Ddx39 expression was significantly up-regulated by
我们利用早期妊娠小鼠第五天的子宫分别构建了非着床位点和着床位点标签长10 bp的两个SAGE文库,非着床位点测序的标签数为51306个,对应16964个特异标签,着床位点测序的标签数为53214个,对应16733个特异的标签。为了提高SAGE库中标签对应基因的比例,我们利用同一个SAGE文库的序列文件,构建了标签长11 bp的两个文库,非着床位点的标签总数为48121,对应16677个特异标签,着床位点的标签总数为50227,对应16696个特异的标签。共有1039个标签在非着床位点特异性表达,1252个标签在着床位点特异性表达。根据p值,195个标签在非着床位点显著上调,其中100个标签是单一匹配的,261个标签在着床位点显著上调,其中127个是单一匹配的。
为了验证SAGE结果的可信性,我们随机选取14个单一匹配的标签对应的基因(其中7个在着床位点上调,7个下调)进行RT-PCR验证,所有这些基因的RT-PCR结果与SAGE结果中的表达趋势一致。我们利用原位杂交对SAGE结果也进行了验证。与非着床位点相比,1810014L12Rik、Psmb5、Cd63、Npm1、Fads3和Tagln2在着床位点处的腔上皮下基质细胞中高表达。Ddx39在第5天着床位点腔上皮下基质中强表达,在非着床位点及假孕第5天未检测到杂交信号。利用假孕及延迟着床模型发现,Ddx39的表达受正在着床的活性胚泡的诱导。在卵巢切除的小鼠中,Ddx39的表达受雌激素显著上调,孕酮对Ddx39的表达没有明显影响。这表明Ddx39可能在胚胎着床过程中发挥重要作用。
总之,我们成功地构建了早期妊娠小鼠第5天子宫的非着床位点和着床位点两个SAGE文库,筛选得到了一批与胚胎着床相关的基因,为进一步研究胚胎着床的分子机理提供了大量有价值的信息。
Implantation is a complex interaction between the uterus and blastocyst. A lot of genes are imvolved in embryo-uterine interactions during implantation. Oligonucleotide chips, cDNA microarrays, differential display RT-PCR and other approaches have been used to screen implantation-related molecules. To identify implantation-related genes and novel pathways during implantation, the differential gene expression between inter-implantation site and implantation site in mouse uterus on day 5 of pregnancy was profiled by serial analysis of gene expression (SAGE). The SAGE libraries of 10 bp tags constructed from mouse uteri at inter-implantation site and implantation site were deposited in the GEO repository. The total numbers of tags sequenced were 51,306 tags for inter-implantation library and 53,214 tags for implantation library, corresponding to 16,964 and 16,733 unique tags, respectively. In order to increase the percentage of the tags with single match, we also used the same sequence files of SAGE libraries to construct two SAGE libraries of 11-bp tags. The total numbers of tags in 11-bp libraries were 48,121 for inter-implantation site and 50,227 for implantation site, corresponding to 16,677 and 16,696 unique tags, respectively. There were 1,039 tags specifically expressed at inter-implantation site, and 1,252 tags specifically expressed at implantation site. Based on p-value, there were 195 tags significantly up-regulated at inter-implantation site and 261 tags significantly up-regulated at implantation site, of which 100 genes were single-matched at inter-implantation site and 127 genes single-matched at implantation site, respectively.
In order to validate SAGE data, RT-PCR was performed to examine differential expression of 14 randomly selected tags with single match, 7 for significantly up-regulated ones and 7 for down-regulated ones. For all of the genes examined, the trend of relative expression of their transcripts was comparable between SAGE and RT-PCR. SAGE data were further confirmed by in situ hybridization. 1810014L12Rik, Psmb5, Cd63, Npm1, Fads3 and Tagln2 were shown to be highly expressed at implantation site compared to inter-implantation site. Compared to inter-implantation site, Ddx39 was strongly expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. Ddx39 expression at implantation site was specifically induced by active blastocysts. Additionally, Ddx39 expression was significantly up-regulated by
引文
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O and et al. 1995. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature 377(6547 Suppl): 3~174.
Altman S 1990. Ribonuclease P. Postscript. J Biol Chem, 265(33): 20053~20056. Anisimov SV, Tarasov KV, Tweedie D, Stern MD, Wobus AM and Boheler KR. 2002. SAGE identification of gene transcripts with profiles unique to pluripotent mouse R1 embryonic stem cells. Genomics, 79(2): 169~176.
Baker BF, Lot SS, Condon TP, Cheng-Flournoy S, Lesnik EA, Sasmor HM and Bennett CF. 1997. 2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J Biol Chem, 272(18): 11994~12000.
Bany BM and Schultz GA. 2001. Increased expression of a novel heat shock protein transcript in the mouse uterus during decidualization and in response to progesterone. Biol Reprod, 64(1): 284~292.
Beauchamp NJ, van Achterberg TA, Engelse MA, Pannekoek H and de Vries CJ. 2003. Gene expression profiling of resting and activated vascular smooth muscle cells by serial analysis of gene expression and clustering analysis. Genomics, 82(3): 288~299.
Benson GV, Lim H, Paria BC, Satokata I, Dey SK and Maas RL. 1996. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development , 122(9): 2687~2696.
Bernstein E, Caudy AA, Hammond SM and Hannon GJ. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409(6818): 363~366.
Blackshaw S, Kuo WP, Park PJ, Tsujikawa M, Gunnersen JM, Scott HS, Boon WM, Tan SS and Cepko CL. 2003. MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. Genome Biol, 4(3): R17.
Blomberg LA and Zuelke KA. 2004. Serial analysis of gene expression (SAGE) during porcine embryo development. Reprod Fertil Dev, 16(2): 87~92.
Bolduc C, Larose M, Lafond N, Yoshioka M, Rodrigue MA, Morissette J, Labrie C, Raymond V and St-Amand J. 2004. Adipose tissue transcriptome by serial analysis of gene expression. Obes Res, 12(5): 750~757.
Bolduc C, Larose M, Yoshioka M, Ye P, Belleau P, Labrie C, Morissette J, Raymond V,
Labrie F and St-Amand J. 2004. Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression. J Mol Endocrinol, 33(2): 429~444.
Boon K, Osorio EC, Greenhut SF, Schaefer CF, Shoemaker J, Polyak K, Morin PJ, Buetow KH, Strausberg RL, De Souza SJ and Riggins GJ. 2002. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A, 99(17): 11287~11292.
Borthwick JM, Charnock-Jones DS, Tom BD, Hull ML, Teirney R, Phillips SC and Smith SK. 2003. Determination of the transcript profile of human endometrium. Mol Hum Reprod 9(1): 19~33.
Brenner S, Johnson M, Bridgham J, Golda G, Lloyd DH, Johnson D, Luo S, McCurdy S, Foy M, Ewan M, Roth R, George D, Eletr S, Albrecht G, Vermaas E, Williams SR, Moon K, Burcham T, Pallas M, DuBridge RB, Kirchner J, Fearon K, Mao J and Corcoran K. 2000. Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol, 18(6): 630~634.
Brigger I, Dubernet C and Couvreur P. 2002. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev, 54(5): 631~651.
Cairns MJ, Saravolac EG and Sun LQ. 2002. Catalytic DNA: a novel tool for gene suppression. Curr Drug Targets, 3(3): 269~279.
Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA and Yoshinaga K. 2000. Embryo implantation. Dev Biol, 223(2): 217~237.
Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, Yuan L, Fritz MA and Lessey B. 2002. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod, 8(9): 871~879.
Cech TR. 1987. The chemistry of self-splicing RNA and RNA enzymes. Science, 236(4808): 1532~1539.
Chen JJ, Lee S, Zhou G, Rowley JD and Wang SM. 2003. Generation of longer cDNA fragments from SAGE tags for gene identification. Methods Mol Biol, 221: 207~222.
Chen JJ, Rowley JD and Wang SM. 2000. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc Natl Acad Sci U S A, 97(1): 349~353.
Chen SH, Babichev Y, Rodrigues N, Voskas D, Ling L, Nguyen VP and Dumont DJ. 2005. Gene expression analysis of Tek/Tie2 signaling. Physiol Genomics, 22(2): 257~267.
Cheon YP, Li Q, Xu X, DeMayo FJ, Bagchi IC and Bagchi MK. 2002. A genomic approach to identify novel progesterone receptor regulated pathways in the uterus during implantation. Mol Endocrinol, 16(12): 2853~2871.
Cho-Vega JH, Troncoso P, Do KA, Rago C, Wang X, Tsavachidis S, Medeiros LJ, Spurgers K, Logothetis C and McDonnell TJ. 2005. Combined laser capture microdissection and serial analysis of gene expression from human tissue samples. Mod Pathol, 18(4): 577~584.
Colinge J and Feger G. 2001. Detecting the impact of sequencing errors on SAGE data. Bioinformatics, 17(9): 840~842.
Colinge J and Feger G. 2001. Improving SAGE di-tag processing. Genome Biol, http://genomebiology.com/2001/2/3/preprint/0002.1
Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA, Jr., Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B and Velculescu VE. 2006. The colorectal microRNAome. Proc Natl Acad Sci U S A, 103(10): 3687~3692.
Curtis Hewitt S, Goulding EH, Eddy EM and Korach KS. 2002. Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Biol Reprod, 67(4): 1268~1277.
Daikoku T, Tranguch S, Friedman DB, Das SK, Smith DF and Dey SK. 2005. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of
Hoxa10 in the periimplantation mouse uterus. Mol Endocrinol, 19(3): 683~697. Das SK, Lim H, Paria BC and Dey SK. 1999. Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. J Mol Endocrinol, 22(1): 91~101.
Datson NA, van der Perk-de Jong J, van den Berg MP, de Kloet ER and Vreugdenhil E. 1999. MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue. Nucleic Acids Res, 27(5): 1300~1307.
Declercq R, Van Aerschot A, Read RJ, Herdewijn P and Van Meervelt L. 2002. Crystal structure of double helical hexitol nucleic acids. J Am Chem Soc, 124(6): 928~933.
Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T and Wang H. 2004. Molecular cues to implantation. Endocr Rev, 25(3): 341~373.
Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED and Siebert PD. 1996. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci U S A, 93(12): 6025~6030.
Dinel S, Bolduc C, Belleau P, Boivin A, Yoshioka M, Calvo E, Piedboeuf B, Snyder EE, Labrie F and St-Amand J. 2005. Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome. Nucleic Acids Res, 33(3): e26.
Ding C and Cantor CR. 2004. Quantitative analysis of nucleic acids--the last few years of progress. J Biochem Mol Biol, 37(1): 1~10.
Divina P and Forejt J. 2004. The Mouse SAGE Site: database of public mouse SAGE libraries. Nucleic Acids Res, 32(Database issue): D482~483.
Divina P, Vlcek C, Strnad P, Paces V and Forejt J. 2005. Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics, 6(1): 29.
Dorsett Y and Tuschl T. 2004. siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov, 3(4): 318~329.
Doudna JA and Cech TR. 2002. The chemical repertoire of natural ribozymes. Nature, 418(6894): 222~228.
Dykxhoorn DM, Novina CD and Sharp PA. 2003. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol, 4(6): 457~467.
Elayadi AN and Corey DR. 2001. Application of PNA and LNA oligomers to chemotherapy. Curr Opin Investig Drugs, 2(4): 558~561.
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K and Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411(6836): 494~498.
Elbashir SM, Lendeckel W and Tuschl T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev, 15(2): 188~200.
Emilsson GM and Breaker RR. 2002. Deoxyribozymes: new activities and new applications. Cell Mol Life Sci, 59(4): 596~607.
Enders AC and Schlafke S. 1969. Cytological aspects of trophoblast-uterine interaction in early implantation. Am J Anat, 125(1): 1~29.
Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J,
Metzger D, Hashimoto S and Kato S. 1999. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Mol Cell Biol, 19(8): 5363~5372.
Esteban JA, Banerjee AR and Burke JM. 1997. Kinetic mechanism of the hairpin ribozyme. Identification and characterization of two nonexchangeable conformations. J Biol Chem, 272(21): 13629~13639.
Evans SJ, Datson NA, Kabbaj M, Thompson RC, Vreugdenhil E, De Kloet ER, Watson SJ and Akil H. 2002. Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression. Eur J Neurosci, 16(3): 409~413.
Farnsworth RL and Talamantes F. 1998. Calcyclin in the mouse decidua: expression and effects on placental lactogen secretion. Biol Reprod, 59(3): 546~552.
Fedor MJ and Uhlenbeck OC. 1992. Kinetics of intermolecular cleavage by hammerhead ribozymes. Biochemistry, 31(48): 12042~12054.
Finn CA and Porter DG. 1975. The uterus: cells and tissues of the endometrium. Publishing Sciences Group, Inc, Acton, MAl.
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391(6669): 806~811.
Fouladi-Nashta AA, Jones CJ, Nijjar N, Mohamet L, Smith A, Chambers I and Kimber SJ. 2005. Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Dev Biol, 281(1): 1~21.
Giudice LC. 2004. Microarray expression profiling reveals candidate genes for human uterine receptivity. Am J Pharmacogenomics, 4(5): 299~312.
Giudice LC, Telles TL, Lobo S and Kao L. 2002. The molecular basis for implantation failure in endometriosis: on the road to discovery. Ann N Y Acad Sci, 955: 252-64; discussion 293-5, 396~406.
Gnatenko DV, Dunn JJ, McCorkle SR, Weissmann D, Perrotta PL and Bahou WF. 2003.
Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood, 101(6): 2285~2293.
Gorski SM, Chittaranjan S, Pleasance ED, Freeman JD, Anderson CL, Varhol RJ, Coughlin SM, Zuyderduyn SD, Jones SJ and Marra MA. 2003. A SAGE approach to discovery of genes involved in autophagic cell death. Curr Biol, 13(4): 358~363.
Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K and Pandolfi PP. 2005. Role of nucleophosmin in embryonic development and tumorigenesis. Nature, 437(7055): 147~53.
Gruidl M, Buyuksal A, Babaknia A, Fazleabas AT, Sivarajah S, Satyaswaroop PG and Tabibzadeh S. 1997. The progressive rise in the expression of alpha crystallin B chain in human endometrium is initiated during the implantation window: modulation of gene expression by steroid hormones. Mol Hum Reprod, 3(4): 333~342.
Guo Y, Wang H, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK and Dey SK. 2005. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem, 280(25): 23429~23432.
Hamatani T, Carter MG, Sharov AA and Ko MS. 2004. Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell, 6(1): 117~131.
Hamatani T, Daikoku T, Wang H, Matsumoto H, Carter MG, Ko MS and Dey SK. 2004. Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc Natl Acad Sci U S A, 101(28): 10326~10331.
Harbers M and Carninci P. 2005. Tag-based approaches for transcriptome research and genome annotation. Nat Methods, 2(7): 495~502.
Hashimoto S, Suzuki Y, Kasai Y, Morohoshi K, Yamada T, Sese J, Morishita S, Sugano S and Matsushima K. 2004. 5'-end SAGE for the analysis of transcriptional start sites. Nat Biotechnol, 22(9): 1146~1149.
Hayrabedyan S, Kyurkchiev S and Kehayov I. 2005. Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis. Reprod Biol, 5(1): 51~67.
Hedrick SM, Cohen DI, Nielsen EA and Davis MM. 1984. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature, 308(5955): 149~153.
Henemyre C and Markoff E. 1998. Decidualization and expression of insulin-like growth factor-I and insulin-like growth factor binding protein-4 in the periimplantation mouse uterus. Biol Reprod, 58(3): 801~806.
Ho SP, Bao Y, Lesher T, Malhotra R, Ma LY, Fluharty SJ and Sakai RR. 1998. Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries. Nat Biotechnol, 16(1): 59~63.
Holman RT, Johnson SB, Gerrard JM, Mauer SM, Kupcho-Sandberg S and Brown DM. 1983. Arachidonic acid deficiency in streptozotocin-induced diabetes. Proc Natl Acad Sci U S A, 80(8): 2375~2379.
Holthe MR, Staff AC, Berge LN and Lyberg T. 2004. Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. Am J Obstet Gynecol, 190(4): 1128~1134.
Horcajadas JA, Riesewijk A, Martin J, Cervero A, Mosselman S, Pellicer A and Simon C. 2004. Global gene expression profiling of human endometrial receptivity. J Reprod Immunol, 63(1): 41~49.
Hubank M and Schatz DG. 1999. cDNA representational difference analysis: a sensitive and flexible method for identification of differentially expressed genes. Methods Enzymol, 303: 325~349.
Ishii M, Hashimoto S, Tsutsumi S, Wada Y, Matsushima K, Kodama T and Aburatani H. 2000. Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis. Genomics, 68(2): 136~143.
Jones RL, Hannan NJ, Kaitu'u TJ, Zhang J and Salamonsen LA. 2004. Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J Clin Endocrinol Metab, 89(12): 6155~6167.
Jones RL, Morison NB, Hannan NJ, Critchley HO and Salamonsen LA. 2005. Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations. Hum Reprod, 20(10): 2724~2735.
Joswig A, Gabriel HD, Kibschull M and Winterhager E. 2003. Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol, 1: 44.
Kaiser M, Gibori G and Mayo KE. 1990. The rat follistatin gene is highly expressed in decidual tissue. Endocrinology, 126(5): 2768~2770.
Kanamori T, Takakura K, Mandai M, Kariya M, Fukuhara K, Sakaguchi M, Huh NH, Saito K, Sakurai T, Fujita J and Fujii S. 2004. Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours. Mol Hum Reprod, 10(10): 735~742.
Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA and Giudice LC 2002.Global gene profiling in human endometrium during the window of implantation. Endocrinology, 143(6): 2119~2138. Kennerdell JR and Carthew RW. 2000. Heritable gene silencing in Drosophila using double-stranded RNA. Nat Biotechnol, 18(8): 896~898.
Kenzelmann M and Muhlemann K. 1999. Substantially enhanced cloning efficiency of SAGE (Serial Analysis of Gene Expression) by adding a heating step to the original protocol. Nucleic Acids Res, 27(3): 917~918.
Khachigian LM. 2002. DNAzymes: cutting a path to a new class of therapeutics. Curr Opin Mol Ther, 4(2): 119~121.
Konijnenberg A, van der Post JA, Mol BW, Schaap MC, Lazarov R, Bleker OP, Boer K and Sturk A. 1997. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study. Am J Obstet Gynecol, 177(2): 434~442.
Kumar S, Li Q, Dua A, Ying YK, Bagchi MK and Bagchi IC. 2001. Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation. J Clin Endocrinol Metab, 86(6): 2420~2427.
Kurreck J. 2003. Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem, 270(8): 1628~1644.
Kuznetsov VA, Knott GD and Bonner RF. 2002. General statistics of stochastic process of gene expression in eukaryotic cells. Genetics, 161(3): 1321~1332.
Laganiere J, Deblois G, Lefebvre C, Bataille AR, Robert F and Giguere V. 2005. From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A, 102(33): 11651~11656.
Lamar EE and Palmer E. 1984. Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains. Cell, 37(1): 171~177.
Larose M, St-Amand J, Yoshioka M, Belleau P, Morissette J, Labrie C, Raymond V and Labrie F. 2004. Transcriptome of mouse uterus by serial analysis of gene expression (SAGE): comparison with skeletal muscle. Mol Reprod Dev, 68(2): 142~148.
Lash AE, Tolstoshev CM, Wagner L, Schuler GD, Strausberg RL, Riggins GJ and Altschul SF. 2000. SAGEmap: a public gene expression resource. Genome Res, 10(7): 1051~1060.
Leaw CL, Ren EC and Choong ML. 2004. Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. Cell Mol Life Sci, 61(17): 2264~2273.
Lee KF, Yao YQ, Kwok KL, Xu JS and Yeung WS. 2002. Early developing embryos affect the gene expression patterns in the mouse oviduct. Biochem Biophys Res Commun, 292(2): 564~570.
Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y and Shivdasani RA. 2005. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development, 132(2): 415~427.
Li Q, Wang J, Armant DR, Bagchi MK and Bagchi IC. 2002. Calcitonin down-regulates E-cadherin expression in rodent uterine epithelium during implantation. J Biol Chem, 277(48): 46447~46455.
Liang P and Pardee AB. 1992. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science, 257(5072): 967~971.
Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD, DuBois RN, Trzaskos JM and Dey SK. 1999. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev, 13(12): 1561~1574.
Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Trzaskos JM and Dey SK. 1997. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell, 91(2): 197~208.
Lim H, Song H, Paria BC, Reese J, Das SK and Dey SK. 2002. Molecules in blastocyst implantation: uterine and embryonic perspectives. Vitam Horm, 64: 43~76.
Linder P and Daugeron MC. 2000. Are DEAD-box proteins becoming respectable helicases? Nat Struct Biol, 7(2): 97~99.
Lobo SC, Huang ST, Germeyer A, Dosiou C, Vo KC, Tulac S, Nayak NR and Giudice LC. 2004. The immune environment in human endometrium during the window of implantation. Am J Reprod Immunol, 52(4): 244~251.
Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H and Brown EL. 1996. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol, 14(13): 1675~1680.
Logan M. 2002. SAGE profiling of the forelimb and hindlimb. Genome Biol, 3(3): REVIEWS1007.
Lopes FL, Desmarais JA and Murphy BD 2004. Embryonic diapause and its regulation. Reproduction 128(6): 669~78.
Lu J, Lal A, Merriman B, Nelson S and Riggins G. 2004. A comparison of gene expression profiles produced by SAGE, long SAGE, and oligonucleotide chips. Genomics, 84(4): 631~636.
Lu QL, Mann CJ, Lou F, Bou-Gharios G, Morris GE, Xue SA, Fletcher S, Partridge TA and Wilton SD. 2003. Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. Nat Med, 9(8): 1009~1014.
Luu KC, Nie GY and Salamonsen LA. 2004. Endometrial calbindins are critical for embryo implantation: evidence from in vivo use of morpholino antisense oligonucleotides. Proc Natl Acad Sci U S A, 101(21): 8028~8033.
Ma WG, Song H, Das SK, Paria BC and Dey SK. 2003. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci U S A, 100(5): 2963~2968.
Manoharan M. 1999. 2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochim Biophys Acta, 1489(1): 117~130.
Manoharan M. 2002. Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action. Antisense Nucleic Acid Drug Dev, 12(2): 103~128.
Margulies EH and Innis JW. 2000. eSAGE: managing and analysing data generated with serial analysis of gene expression (SAGE). Bioinformatics, 16(7): 650~651.
Markoff E, Henemyre C, Fellows J, Pennington E, Zeitler PS and Cedars MI. 1995. Localization of insulin-like growth factor binding protein-4 expression in the mouse uterus during the peri-implantation period. Biol Reprod, 53(5): 1103~1109.
Mathews DH, Sabina J, Zuker M and Turner DH. 1999. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol, 288(5): 911~140.
Matsumura H, Ito A, Saitoh H, Winter P, Kahl G, Reuter M, Kruger DH and Terauchi R. 2005. SuperSAGE. Cell Microbiol, 7(1): 11~18.
Matsumura H, Reich S, Ito A, Saitoh H, Kamoun S, Winter P, Kahl G, Reuter M, Kruger DH and Terauchi R. 2003. Gene expression analysis of plant host-pathogen interactions by SuperSAGE. Proc Natl Acad Sci U S A, 100(26): 15718~15723.
Maurer N, Fenske DB and Cullis PR. 2001. Developments in liposomal drug delivery systems. Expert Opin Biol Ther, 1(6): 923~947.
McRae RS, Johnston HM, Mihm M and O'Shaughnessy PJ. 2005. Changes in mouse granulosa cell gene expression during early luteinization. Endocrinology, 146(1): 309~317. Metivier R, Penot G, Hubner MR, Reid G, Brand H, Kos M and Gannon F. 2003.
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell, 115(6): 751~763.
Milner N, Mir KU and Southern EM. 1997. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat Biotechnol, 15(6): 537~541.
Mirkin S, Arslan M, Churikov D, Corica A, Diaz JI, Williams S, Bocca S and Oehninger S. 2005. In search of candidate genes critically expressed in the human endometrium during the window of implantation. Hum Reprod, 20(8): 2104~2117.
Morita K, Takagi M, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, Ishikawa T, Imanishi T and Koizumi M. 2003. Synthesis and properties of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) as effective antisense oligonucleotides. Bioorg Med Chem, 11(10): 2211~2226.
Munasinghe A, Patankar S, Cook BP, Madden SL, Martin RK, Kyle DE, Shoaibi A, Cummings LM and Wirth DF. 2001. Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes. Mol Biochem Parasitol, 113(1): 23~34.
Nakamura MT and Nara TY. 2004. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr, 24: 345~376.
Neilson L, Andalibi A, Kang D, Coutifaris C, Strauss JF, 3rd, Stanton JA and Green DP. 2000. Molecular phenotype of the human oocyte by PCR-SAGE. Genomics, 63(1): 13~24.
Ni H, Ding NZ, Harper MJ and Yang ZM. 2002. Expression of leukemia inhibitory factor receptor and gp130 in mouse uterus during early pregnancy. Mol Reprod Dev, 63(2): 143~150.
Ni H, Sun T, Ding NZ, Ma XH and Yang ZM. 2002. Differential expression of microsomal prostaglandin e synthase at implantation sites and in decidual cells of mouse uterus. Biol Reprod, 67(1): 351~358.
Nie G, Li Y, Wang M, Liu YX, Findlay JK and Salamonsen LA. 2005. Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility. Biol Reprod, 72(4): 1029~1036.
Nie GY, Li Y, Batten L, Griffiths B, Wang J, Findlay JK and Salamonsen LA. 2000. Uterine expression of alternatively spliced mRNAs of mouse splicing factor SC35 during early pregnancy. Mol Hum Reprod, 6(12): 1131~1139.
Nie GY, Li Y, Hampton AL, Salamonsen LA, Clements JA and Findlay JK. 2000. Identification of monoclonal nonspecific suppressor factor beta (mNSFbeta) as one of the genes differentially expressed at implantation sites compared to interimplantation sites in the mouse uterus. Mol Reprod Dev, 55(4): 351~363.
Nie GY, Li Y, Minoura H, Findlay JK and Salamonsen LA. 2003. Specific and transient up-regulation of proprotein convertase 6 at the site of embryo implantation and identification of a unique transcript in mouse uterus during early pregnancy. Biol Reprod, 68(2): 439~447.
Nie GY, Li Y, Wang J, Minoura H, Findlay JK and Salamonsen LA. 2000. Complex regulation of calcium-binding protein D9k (calbindin-D(9k)) in the mouse uterus during early pregnancy and at the site of embryo implantation. Biol Reprod, 62(1): 27~36.
Okada H, Sanezumi M, Nakajima T, Okada S, Yasuda K and Kanzaki H. 1999. Rapid down-regulation of CD63 transcription by progesterone in human endometrial stromal cells. Mol Hum Reprod, 5(6): 554~558.
Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM and Lieberman J. 2006. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature, 439(7072): 89~94.
Paria BC, Das SK, Andrews GK and Dey SK. 1993. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc Natl Acad Sci U S A, 90(1): 55~59.
Paria BC, Das SK and Dey SK. 1995. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A, 92(21): 9460~9464.
Paria BC, Huet-Hudson YM and Dey SK. 1993. Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterus. Proc Natl Acad Sci U S A, 90(21): 10159~10162.
Paria BC, Lim H, Wang XN, Liehr J, Das SK and Dey SK. 1998. Coordination of differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse. Endocrinology, 139(12): 5235~5246.
Paria BC, Reese J, Das SK and Dey SK. 2002. Deciphering the cross-talk of implantation: advances and challenges. Science, 296(5576): 2185~2188.
Paria BC, Song H, Wang X, Schmid PC, Krebsbach RJ, Schmid HH, Bonner TI, Zimmer A and Dey SK. 2001. Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation. J Biol Chem. 276(23): 20523~20528.
Parr EL, Tung HN and Parr MB. 1987. Apoptosis as the mode of uterine epithelial cell death during embryo implantation in mice and rats. Biol Reprod, 36(1): 211~225.
Passey RJ, Williams E, Lichanska AM, Wells C, Hu S, Geczy CL, Little MH and Hume DA. 1999. A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol, 163(4): 2209~2216.
Peng S, York JP and Zhang P. 2006. A transgenic approach for RNA interference-based genetic screening in mice. Proc Natl Acad Sci U S A, 103(7): 2252~2256.
Peters DG, Kassam AB, Yonas H, O'Hare EH, Ferrell RE and Brufsky AM. 1999. Comprehensive transcript analysis in small quantities of mRNA by SAGE-lite. Nucleic Acids Res, 27(24): e39.
Pleasance ED, Marra MA and Jones SJ. 2003. Assessment of SAGE in transcript identification. Genome Res, 13(6A): 1203~1215.
Poisson, j. p. g and Cunnane S. 1991. Long-chain fatty acid metabolism in fasting and diabetes: relation between altered desaturase activity and fatty acid composition J. Nutr. Biochem,. 2(2): 60~70.
Popovici RM, Kao LC and Giudice LC. 2000. Discovery of new inducible genes in in vitro decidualized human endometrial stromal cells using microarray technology. Endocrinology, 141(9): 3510~3513.
Porter DA, Krop IE, Nasser S, Sgroi D, Kaelin CM, Marks JR, Riggins G and Polyak K. 2001. A SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res, 61(15): 5697~702.
Powell J. 1998. Enhanced concatemer cloning-a modification to the SAGE (Serial Analysis of Gene Expression) technique. Nucleic Acids Res, 26(14): 3445~3446.
Raab G, Kover K, Paria BC, Dey SK, Ezzell RM and Klagsbrun M. 1996. Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor. Development, 122(2): 637~645.
Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M and Fisher SJ. 2004. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest, 114(6): 744~754.
Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN and Dey SK. 2001. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J Biol Chem, 276(47): 44137~44145.
Renfree MB and Shaw G. 2000. Diapause. Annu Rev Physiol, 62: 353~375.
Riddell SR, Elliott M, Lewinsohn DA, Gilbert MJ, Wilson L, Manley SA, Lupton SD, Overell RW, Reynolds TC, Corey L and Greenberg PD. 1996. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med, 2(2): 216~223.
Riesewijk A, Martin J, van Os R, Horcajadas JA, Polman J, Pellicer A, Mosselman S and Simon C. 2003. Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Mol Hum Reprod, 9(5): 253~264.
Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Ratajczak CK and Moley KH. 2005. The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev Biol, 284(2): 377~386.
Robb L, Li R, Hartley L, Nandurkar HH, Koentgen F and Begley CG. 1998. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med, 4(3): 303~308.
Ryo A, Kondoh N, Wakatsuki T, Hada A, Yamamoto N and Yamamoto M. 2000. A modified serial analysis of gene expression that generates longer sequence tags by nonpalindromic cohesive linker ligation. Anal Biochem, 277(1): 160~162.
Saha S, Sparks AB, Rago C, Akmaev V, Wang CJ, Vogelstein B, Kinzler KW and Velculescu VE. 2002. Using the transcriptome to annotate the genome. Nat Biotechnol, 20(5): 508~512.
Salamonsen LA, Nie G and Findlay JK. 2002. Newly identified endometrial genes of importance for implantation. J Reprod Immunol, 53(1~2): 215~225.
Santoro SW and Joyce GF. 1997. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci U S A, 94(9): 4262~4266.
Santoro SW and Joyce GF. 1998. Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry, 37(38): 13330~13342.
Sidhu SS and Kimber SJ. 1999. Hormonal control of H-type alpha(1-2)fucosyltransferase messenger ribonucleic acid in the mouse uterus. Biol Reprod, 60(1): 147~157.
Simmons DG and Kennedy TG. 2000. Induction of glucose-regulated protein 78 in rat uterine glandular epithelium during uterine sensitization for the decidual cell reaction. Biol Reprod, 62(5): 1168~1176.
Simmons DG and Kennedy TG. 2004. Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control. Reproduction, 127(4): 475~482.
Sledz CA, Holko M, de Veer MJ, Silverman RH and Williams BR. 2003. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol, 5(9): 834~839.
Song H, Lim H, Das SK, Paria BC and Dey SK. 2000. Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. Mol Endocrinol, 14(8): 1147~1161.
Stachecki JJ and Armant DR. 1996. Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development. Development, 122(8): 2485~2496.
Stark GR, Kerr IM, Williams BR, Silverman RH and Schreiber RD. 1998. How cells respond to interferons. Annu Rev Biochem, 67: 227~264.
Stern MD, Anisimov SV and Boheler KR. 2003. Can transcriptome size be estimated from SAGE catalogs? Bioinformatics, 19(4): 443~448.
Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Kontgen F and Abbondanzo SJ. 1992. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature, 359(6390): 76~79.
Summerton J. 1999. Morpholino antisense oligomers: the case for an RNase H-independent structural type. Biochim Biophys Acta, 1489(1): 141~158.
Sun XY, Li FX, Li J, Tan YF, Piao YS, Tang S and Wang YL. 2004. Determination of genes involved in the early process of embryonic implantation in rhesus monkey (Macaca mulatta) by suppression subtractive hybridization. Biol Reprod, 70(5): 1365~1373.
Svoboda P, Stein P and Schultz RM. 2001. RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA. Biochem Biophys Res Commun, 287(5): 1099-1104.
Tatsumi K, Higuchi T, Fujiwara H, Nakayama T, Fujii S and Fujita J. 2001. Expression of Ly-6A/E in the mouse uterus during implantation period. Mol Reprod Dev, 58(2): 159~165.
Tavernarakis N, Wang SL, Dorovkov M, Ryazanov A and Driscoll M. 2000. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet, 24(2): 180~183.
Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF and Dey SK. 2005. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A, 102(40): 14326~14331.
Tranguch S, Daikoku T, Guo Y, Wang H and Dey SK. 2005. Molecular complexity in establishing uterine receptivity and implantation. Cell Mol Life Sci, 62(17): 1964~1973.
Uil TG, Haisma HJ and Rots MG. 2003. Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities. Nucleic Acids Res, 31(21): 6064~6078.
Unneberg P, Wennborg A and Larsson M. 2003. Transcript identification by analysis of short sequence tags--influence of tag length, restriction site and transcript database. Nucleic Acids Res, 31(8): 2217~2226.
Ushizawa K, Herath CB, Kaneyama K, Shiojima S, Hirasawa A, Takahashi T, Imai K, Ochiai K, Tokunaga T, Tsunoda Y, Tsujimoto G and Hashizume K. 2004. cDNA microarray analysis of bovine embryo gene expression profiles during the pre-implantation period. Reprod Biol Endocrinol, 2(1): 77.
Velculescu VE, Zhang L, Vogelstein B and Kinzler KW. 1995. Serial analysis of gene expression. Science, 270(5235): 484~487.
Velculescu VE, Zhang L, Zhou W, Vogelstein J, Basrai MA, Bassett DE, Jr., Hieter P, Vogelstein B and Kinzler KW. 1997. Characterization of the yeast transcriptome. Cell, 88(2): 243~251.
Vilain C, Libert F, Venet D, Costagliola S and Vassart G. 2003. Small amplified RNA-SAGE: an alternative approach to study transcriptome from limiting amount of mRNA. Nucleic Acids Res, 31(6): e24.
Virlon B, Cheval L, Buhler JM, Billon E, Doucet A and Elalouf JM. 1999. Serial microanalysis of renal transcriptomes. Proc Natl Acad Sci U S A, 96(26): 15286~15291.
Wadehra M, Dayal M, Mainigi M, Ord T, Iyer R, Braun J and Williams CJ. 2006. Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. Dev Biol, 15;292(2):430~41.
Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ and Braun J. 2005. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol, 287(2): 336~345.
Wang H and Dey SK. 2006. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet, 7(3): 185-199.
Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN and Dey SK. 2004. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med, 10(10): 1074~1080.
Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL and Dey SK. 2003. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci U S A, 100(25): 14914~14919.
Wang H, Wang S, Nan L, Yu D, Agrawal S and Zhang R. 2002. Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. Int J Oncol, 20(4): 745~752.
Wang H, Xie H, Zhang H, Das SK and Dey SK. 2006. Conditional gene recombination by adenovirus-driven Cre in the mouse uterus. Genesis, 44(2): 51~56.
Wang J, Mayernik L, Schultz JF and Armant DR. 2000. Acceleration of trophoblast differentiation by heparin-binding EGF-like growth factor is dependent on the stage-specific activation of calcium influx by ErbB receptors in developing mouse blastocysts. Development, 127(1): 33~44.
Wang QT, Piotrowska K, Ciemerych MA, Milenkovic L, Scott MP, Davis RW and Zernicka-Goetz M. 2004. A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell, 6(1): 133~144.
Wang Y and Guthrie C. 1998. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. RNA, 4(10): 1216~1229.
Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y and Kato S. 2001. A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J, 20(6): 1341~152.
Waterhouse P, Parhar RS, Guo X, Lala PK and Denhardt DT. 1992. Regulated temporal and spatial expression of the calcium-binding proteins calcyclin and OPN (osteopontin) in mouse tissues during pregnancy. Mol Reprod Dev, 32(4): 315~323.
Wei CL, Ng P, Chiu KP, Wong CH, Ang CC, Lipovich L, Liu ET and Ruan Y. 2004. 5' Long serial analysis of gene expression (LongSAGE) and 3' LongSAGE for transcriptome characterization and genome annotation. Proc Natl Acad Sci U S A, 101(32): 11701~11706.
Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND and Fuller-Pace FV. 2004. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol Biol, 5: 11.
Yamamoto M, Wakatsuki T, Hada A and Ryo A. 2001. Use of serial analysis of gene expression (SAGE) technology. J Immunol Methods, 250(1~2): 45-66.
Yang YJ, Liu WM, Zhou JX, Cao YJ, Li J, Peng S, Wang L, Yuan JG and Duan EK. 2006. Expression and hormonal regulation of calcyclin-binding protein (CacyBP) in the mouse uterus during early pregnancy. Life Sci, 78(7): 753~760.
Ye SQ, Lavoie T, Usher DC and Zhang LQ. 2002. Microarray, SAGE and their applications to cardiovascular diseases. Cell Res, 12(2): 105~115.
Yoon SJ, Choi DH, Lee WS, Cha KY, Kim SN and Lee KA. 2004. A molecular basis for embryo apposition at the luminal epithelium. Mol Cell Endocrinol, 219(1-2): 95~104.
Yoshinaga K and Adams CE. 1966. Delayed implantation in the spayed, progesterone treated adult mouse. J Reprod Fertil, 12(3): 593~595.
Yoshioka K, Matsuda F, Takakura K, Noda Y, Imakawa K and Sakai S. 2000. Determination of genes involved in the process of implantation: application of GeneChip to scan 6500 genes. Biochem Biophys Res Commun, 272(2): 531~538.
Zamecnik PC and Stephenson ML. 1978. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci U S A, 75(1): 280~284.
Zamore PD. 2002. Ancient pathways programmed by small RNAs. Science, 296(5571): 1265~1269.
Zamore PD, Tuschl T, Sharp PA and Bartel DP. 2000. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101(1): 25~33.
Zeng F, Baldwin DA and Schultz RM. 2004. Transcript profiling during preimplantation mouse development. Dev Biol, 272(2): 483~496.
Zhang L, Gasper WJ, Stass SA, Ioffe OB, Davis MA and Mixson AJ. 2002. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res, 62(19): 5463~5469.
Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B and Kinzler KW. 1997. Gene expression profiles in normal and cancer cells. Science, 276(5316): 1268~1272.
Zhu LJ, Bagchi MK and Bagchi IC. 1998. Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation. Endocrinology, 139(1): 330~339.
Zolfaghari R and Ross AC. 2003. Recent advances in molecular cloning of fatty acid desaturase genes and the regulation of their expression by dietary vitamin A and retinoic acid, Prostaglandins Leukot Essent Fatty Acids, 68(2): 171~179.
Altman S 1990. Ribonuclease P. Postscript. J Biol Chem, 265(33): 20053~20056. Anisimov SV, Tarasov KV, Tweedie D, Stern MD, Wobus AM and Boheler KR. 2002. SAGE identification of gene transcripts with profiles unique to pluripotent mouse R1 embryonic stem cells. Genomics, 79(2): 169~176.
Baker BF, Lot SS, Condon TP, Cheng-Flournoy S, Lesnik EA, Sasmor HM and Bennett CF. 1997. 2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells. J Biol Chem, 272(18): 11994~12000.
Bany BM and Schultz GA. 2001. Increased expression of a novel heat shock protein transcript in the mouse uterus during decidualization and in response to progesterone. Biol Reprod, 64(1): 284~292.
Beauchamp NJ, van Achterberg TA, Engelse MA, Pannekoek H and de Vries CJ. 2003. Gene expression profiling of resting and activated vascular smooth muscle cells by serial analysis of gene expression and clustering analysis. Genomics, 82(3): 288~299.
Benson GV, Lim H, Paria BC, Satokata I, Dey SK and Maas RL. 1996. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development , 122(9): 2687~2696.
Bernstein E, Caudy AA, Hammond SM and Hannon GJ. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409(6818): 363~366.
Blackshaw S, Kuo WP, Park PJ, Tsujikawa M, Gunnersen JM, Scott HS, Boon WM, Tan SS and Cepko CL. 2003. MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. Genome Biol, 4(3): R17.
Blomberg LA and Zuelke KA. 2004. Serial analysis of gene expression (SAGE) during porcine embryo development. Reprod Fertil Dev, 16(2): 87~92.
Bolduc C, Larose M, Lafond N, Yoshioka M, Rodrigue MA, Morissette J, Labrie C, Raymond V and St-Amand J. 2004. Adipose tissue transcriptome by serial analysis of gene expression. Obes Res, 12(5): 750~757.
Bolduc C, Larose M, Yoshioka M, Ye P, Belleau P, Labrie C, Morissette J, Raymond V,
Labrie F and St-Amand J. 2004. Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression. J Mol Endocrinol, 33(2): 429~444.
Boon K, Osorio EC, Greenhut SF, Schaefer CF, Shoemaker J, Polyak K, Morin PJ, Buetow KH, Strausberg RL, De Souza SJ and Riggins GJ. 2002. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A, 99(17): 11287~11292.
Borthwick JM, Charnock-Jones DS, Tom BD, Hull ML, Teirney R, Phillips SC and Smith SK. 2003. Determination of the transcript profile of human endometrium. Mol Hum Reprod 9(1): 19~33.
Brenner S, Johnson M, Bridgham J, Golda G, Lloyd DH, Johnson D, Luo S, McCurdy S, Foy M, Ewan M, Roth R, George D, Eletr S, Albrecht G, Vermaas E, Williams SR, Moon K, Burcham T, Pallas M, DuBridge RB, Kirchner J, Fearon K, Mao J and Corcoran K. 2000. Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol, 18(6): 630~634.
Brigger I, Dubernet C and Couvreur P. 2002. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev, 54(5): 631~651.
Cairns MJ, Saravolac EG and Sun LQ. 2002. Catalytic DNA: a novel tool for gene suppression. Curr Drug Targets, 3(3): 269~279.
Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA and Yoshinaga K. 2000. Embryo implantation. Dev Biol, 223(2): 217~237.
Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, Yuan L, Fritz MA and Lessey B. 2002. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod, 8(9): 871~879.
Cech TR. 1987. The chemistry of self-splicing RNA and RNA enzymes. Science, 236(4808): 1532~1539.
Chen JJ, Lee S, Zhou G, Rowley JD and Wang SM. 2003. Generation of longer cDNA fragments from SAGE tags for gene identification. Methods Mol Biol, 221: 207~222.
Chen JJ, Rowley JD and Wang SM. 2000. Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc Natl Acad Sci U S A, 97(1): 349~353.
Chen SH, Babichev Y, Rodrigues N, Voskas D, Ling L, Nguyen VP and Dumont DJ. 2005. Gene expression analysis of Tek/Tie2 signaling. Physiol Genomics, 22(2): 257~267.
Cheon YP, Li Q, Xu X, DeMayo FJ, Bagchi IC and Bagchi MK. 2002. A genomic approach to identify novel progesterone receptor regulated pathways in the uterus during implantation. Mol Endocrinol, 16(12): 2853~2871.
Cho-Vega JH, Troncoso P, Do KA, Rago C, Wang X, Tsavachidis S, Medeiros LJ, Spurgers K, Logothetis C and McDonnell TJ. 2005. Combined laser capture microdissection and serial analysis of gene expression from human tissue samples. Mod Pathol, 18(4): 577~584.
Colinge J and Feger G. 2001. Detecting the impact of sequencing errors on SAGE data. Bioinformatics, 17(9): 840~842.
Colinge J and Feger G. 2001. Improving SAGE di-tag processing. Genome Biol, http://genomebiology.com/2001/2/3/preprint/0002.1
Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA, Jr., Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B and Velculescu VE. 2006. The colorectal microRNAome. Proc Natl Acad Sci U S A, 103(10): 3687~3692.
Curtis Hewitt S, Goulding EH, Eddy EM and Korach KS. 2002. Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Biol Reprod, 67(4): 1268~1277.
Daikoku T, Tranguch S, Friedman DB, Das SK, Smith DF and Dey SK. 2005. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of
Hoxa10 in the periimplantation mouse uterus. Mol Endocrinol, 19(3): 683~697. Das SK, Lim H, Paria BC and Dey SK. 1999. Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. J Mol Endocrinol, 22(1): 91~101.
Datson NA, van der Perk-de Jong J, van den Berg MP, de Kloet ER and Vreugdenhil E. 1999. MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue. Nucleic Acids Res, 27(5): 1300~1307.
Declercq R, Van Aerschot A, Read RJ, Herdewijn P and Van Meervelt L. 2002. Crystal structure of double helical hexitol nucleic acids. J Am Chem Soc, 124(6): 928~933.
Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T and Wang H. 2004. Molecular cues to implantation. Endocr Rev, 25(3): 341~373.
Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED and Siebert PD. 1996. Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci U S A, 93(12): 6025~6030.
Dinel S, Bolduc C, Belleau P, Boivin A, Yoshioka M, Calvo E, Piedboeuf B, Snyder EE, Labrie F and St-Amand J. 2005. Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome. Nucleic Acids Res, 33(3): e26.
Ding C and Cantor CR. 2004. Quantitative analysis of nucleic acids--the last few years of progress. J Biochem Mol Biol, 37(1): 1~10.
Divina P and Forejt J. 2004. The Mouse SAGE Site: database of public mouse SAGE libraries. Nucleic Acids Res, 32(Database issue): D482~483.
Divina P, Vlcek C, Strnad P, Paces V and Forejt J. 2005. Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics, 6(1): 29.
Dorsett Y and Tuschl T. 2004. siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov, 3(4): 318~329.
Doudna JA and Cech TR. 2002. The chemical repertoire of natural ribozymes. Nature, 418(6894): 222~228.
Dykxhoorn DM, Novina CD and Sharp PA. 2003. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol, 4(6): 457~467.
Elayadi AN and Corey DR. 2001. Application of PNA and LNA oligomers to chemotherapy. Curr Opin Investig Drugs, 2(4): 558~561.
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K and Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411(6836): 494~498.
Elbashir SM, Lendeckel W and Tuschl T. 2001. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev, 15(2): 188~200.
Emilsson GM and Breaker RR. 2002. Deoxyribozymes: new activities and new applications. Cell Mol Life Sci, 59(4): 596~607.
Enders AC and Schlafke S. 1969. Cytological aspects of trophoblast-uterine interaction in early implantation. Am J Anat, 125(1): 1~29.
Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J,
Metzger D, Hashimoto S and Kato S. 1999. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Mol Cell Biol, 19(8): 5363~5372.
Esteban JA, Banerjee AR and Burke JM. 1997. Kinetic mechanism of the hairpin ribozyme. Identification and characterization of two nonexchangeable conformations. J Biol Chem, 272(21): 13629~13639.
Evans SJ, Datson NA, Kabbaj M, Thompson RC, Vreugdenhil E, De Kloet ER, Watson SJ and Akil H. 2002. Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression. Eur J Neurosci, 16(3): 409~413.
Farnsworth RL and Talamantes F. 1998. Calcyclin in the mouse decidua: expression and effects on placental lactogen secretion. Biol Reprod, 59(3): 546~552.
Fedor MJ and Uhlenbeck OC. 1992. Kinetics of intermolecular cleavage by hammerhead ribozymes. Biochemistry, 31(48): 12042~12054.
Finn CA and Porter DG. 1975. The uterus: cells and tissues of the endometrium. Publishing Sciences Group, Inc, Acton, MAl.
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE and Mello CC. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391(6669): 806~811.
Fouladi-Nashta AA, Jones CJ, Nijjar N, Mohamet L, Smith A, Chambers I and Kimber SJ. 2005. Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Dev Biol, 281(1): 1~21.
Giudice LC. 2004. Microarray expression profiling reveals candidate genes for human uterine receptivity. Am J Pharmacogenomics, 4(5): 299~312.
Giudice LC, Telles TL, Lobo S and Kao L. 2002. The molecular basis for implantation failure in endometriosis: on the road to discovery. Ann N Y Acad Sci, 955: 252-64; discussion 293-5, 396~406.
Gnatenko DV, Dunn JJ, McCorkle SR, Weissmann D, Perrotta PL and Bahou WF. 2003.
Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood, 101(6): 2285~2293.
Gorski SM, Chittaranjan S, Pleasance ED, Freeman JD, Anderson CL, Varhol RJ, Coughlin SM, Zuyderduyn SD, Jones SJ and Marra MA. 2003. A SAGE approach to discovery of genes involved in autophagic cell death. Curr Biol, 13(4): 358~363.
Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K and Pandolfi PP. 2005. Role of nucleophosmin in embryonic development and tumorigenesis. Nature, 437(7055): 147~53.
Gruidl M, Buyuksal A, Babaknia A, Fazleabas AT, Sivarajah S, Satyaswaroop PG and Tabibzadeh S. 1997. The progressive rise in the expression of alpha crystallin B chain in human endometrium is initiated during the implantation window: modulation of gene expression by steroid hormones. Mol Hum Reprod, 3(4): 333~342.
Guo Y, Wang H, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK and Dey SK. 2005. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem, 280(25): 23429~23432.
Hamatani T, Carter MG, Sharov AA and Ko MS. 2004. Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell, 6(1): 117~131.
Hamatani T, Daikoku T, Wang H, Matsumoto H, Carter MG, Ko MS and Dey SK. 2004. Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc Natl Acad Sci U S A, 101(28): 10326~10331.
Harbers M and Carninci P. 2005. Tag-based approaches for transcriptome research and genome annotation. Nat Methods, 2(7): 495~502.
Hashimoto S, Suzuki Y, Kasai Y, Morohoshi K, Yamada T, Sese J, Morishita S, Sugano S and Matsushima K. 2004. 5'-end SAGE for the analysis of transcriptional start sites. Nat Biotechnol, 22(9): 1146~1149.
Hayrabedyan S, Kyurkchiev S and Kehayov I. 2005. Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis. Reprod Biol, 5(1): 51~67.
Hedrick SM, Cohen DI, Nielsen EA and Davis MM. 1984. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature, 308(5955): 149~153.
Henemyre C and Markoff E. 1998. Decidualization and expression of insulin-like growth factor-I and insulin-like growth factor binding protein-4 in the periimplantation mouse uterus. Biol Reprod, 58(3): 801~806.
Ho SP, Bao Y, Lesher T, Malhotra R, Ma LY, Fluharty SJ and Sakai RR. 1998. Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries. Nat Biotechnol, 16(1): 59~63.
Holman RT, Johnson SB, Gerrard JM, Mauer SM, Kupcho-Sandberg S and Brown DM. 1983. Arachidonic acid deficiency in streptozotocin-induced diabetes. Proc Natl Acad Sci U S A, 80(8): 2375~2379.
Holthe MR, Staff AC, Berge LN and Lyberg T. 2004. Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. Am J Obstet Gynecol, 190(4): 1128~1134.
Horcajadas JA, Riesewijk A, Martin J, Cervero A, Mosselman S, Pellicer A and Simon C. 2004. Global gene expression profiling of human endometrial receptivity. J Reprod Immunol, 63(1): 41~49.
Hubank M and Schatz DG. 1999. cDNA representational difference analysis: a sensitive and flexible method for identification of differentially expressed genes. Methods Enzymol, 303: 325~349.
Ishii M, Hashimoto S, Tsutsumi S, Wada Y, Matsushima K, Kodama T and Aburatani H. 2000. Direct comparison of GeneChip and SAGE on the quantitative accuracy in transcript profiling analysis. Genomics, 68(2): 136~143.
Jones RL, Hannan NJ, Kaitu'u TJ, Zhang J and Salamonsen LA. 2004. Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J Clin Endocrinol Metab, 89(12): 6155~6167.
Jones RL, Morison NB, Hannan NJ, Critchley HO and Salamonsen LA. 2005. Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations. Hum Reprod, 20(10): 2724~2735.
Joswig A, Gabriel HD, Kibschull M and Winterhager E. 2003. Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reprod Biol Endocrinol, 1: 44.
Kaiser M, Gibori G and Mayo KE. 1990. The rat follistatin gene is highly expressed in decidual tissue. Endocrinology, 126(5): 2768~2770.
Kanamori T, Takakura K, Mandai M, Kariya M, Fukuhara K, Sakaguchi M, Huh NH, Saito K, Sakurai T, Fujita J and Fujii S. 2004. Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours. Mol Hum Reprod, 10(10): 735~742.
Kao LC, Tulac S, Lobo S, Imani B, Yang JP, Germeyer A, Osteen K, Taylor RN, Lessey BA and Giudice LC 2002.Global gene profiling in human endometrium during the window of implantation. Endocrinology, 143(6): 2119~2138. Kennerdell JR and Carthew RW. 2000. Heritable gene silencing in Drosophila using double-stranded RNA. Nat Biotechnol, 18(8): 896~898.
Kenzelmann M and Muhlemann K. 1999. Substantially enhanced cloning efficiency of SAGE (Serial Analysis of Gene Expression) by adding a heating step to the original protocol. Nucleic Acids Res, 27(3): 917~918.
Khachigian LM. 2002. DNAzymes: cutting a path to a new class of therapeutics. Curr Opin Mol Ther, 4(2): 119~121.
Konijnenberg A, van der Post JA, Mol BW, Schaap MC, Lazarov R, Bleker OP, Boer K and Sturk A. 1997. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study. Am J Obstet Gynecol, 177(2): 434~442.
Kumar S, Li Q, Dua A, Ying YK, Bagchi MK and Bagchi IC. 2001. Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation. J Clin Endocrinol Metab, 86(6): 2420~2427.
Kurreck J. 2003. Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem, 270(8): 1628~1644.
Kuznetsov VA, Knott GD and Bonner RF. 2002. General statistics of stochastic process of gene expression in eukaryotic cells. Genetics, 161(3): 1321~1332.
Laganiere J, Deblois G, Lefebvre C, Bataille AR, Robert F and Giguere V. 2005. From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc Natl Acad Sci U S A, 102(33): 11651~11656.
Lamar EE and Palmer E. 1984. Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains. Cell, 37(1): 171~177.
Larose M, St-Amand J, Yoshioka M, Belleau P, Morissette J, Labrie C, Raymond V and Labrie F. 2004. Transcriptome of mouse uterus by serial analysis of gene expression (SAGE): comparison with skeletal muscle. Mol Reprod Dev, 68(2): 142~148.
Lash AE, Tolstoshev CM, Wagner L, Schuler GD, Strausberg RL, Riggins GJ and Altschul SF. 2000. SAGEmap: a public gene expression resource. Genome Res, 10(7): 1051~1060.
Leaw CL, Ren EC and Choong ML. 2004. Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. Cell Mol Life Sci, 61(17): 2264~2273.
Lee KF, Yao YQ, Kwok KL, Xu JS and Yeung WS. 2002. Early developing embryos affect the gene expression patterns in the mouse oviduct. Biochem Biophys Res Commun, 292(2): 564~570.
Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y and Shivdasani RA. 2005. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development, 132(2): 415~427.
Li Q, Wang J, Armant DR, Bagchi MK and Bagchi IC. 2002. Calcitonin down-regulates E-cadherin expression in rodent uterine epithelium during implantation. J Biol Chem, 277(48): 46447~46455.
Liang P and Pardee AB. 1992. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science, 257(5072): 967~971.
Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD, DuBois RN, Trzaskos JM and Dey SK. 1999. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev, 13(12): 1561~1574.
Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Trzaskos JM and Dey SK. 1997. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell, 91(2): 197~208.
Lim H, Song H, Paria BC, Reese J, Das SK and Dey SK. 2002. Molecules in blastocyst implantation: uterine and embryonic perspectives. Vitam Horm, 64: 43~76.
Linder P and Daugeron MC. 2000. Are DEAD-box proteins becoming respectable helicases? Nat Struct Biol, 7(2): 97~99.
Lobo SC, Huang ST, Germeyer A, Dosiou C, Vo KC, Tulac S, Nayak NR and Giudice LC. 2004. The immune environment in human endometrium during the window of implantation. Am J Reprod Immunol, 52(4): 244~251.
Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H and Brown EL. 1996. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol, 14(13): 1675~1680.
Logan M. 2002. SAGE profiling of the forelimb and hindlimb. Genome Biol, 3(3): REVIEWS1007.
Lopes FL, Desmarais JA and Murphy BD 2004. Embryonic diapause and its regulation. Reproduction 128(6): 669~78.
Lu J, Lal A, Merriman B, Nelson S and Riggins G. 2004. A comparison of gene expression profiles produced by SAGE, long SAGE, and oligonucleotide chips. Genomics, 84(4): 631~636.
Lu QL, Mann CJ, Lou F, Bou-Gharios G, Morris GE, Xue SA, Fletcher S, Partridge TA and Wilton SD. 2003. Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse. Nat Med, 9(8): 1009~1014.
Luu KC, Nie GY and Salamonsen LA. 2004. Endometrial calbindins are critical for embryo implantation: evidence from in vivo use of morpholino antisense oligonucleotides. Proc Natl Acad Sci U S A, 101(21): 8028~8033.
Ma WG, Song H, Das SK, Paria BC and Dey SK. 2003. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci U S A, 100(5): 2963~2968.
Manoharan M. 1999. 2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochim Biophys Acta, 1489(1): 117~130.
Manoharan M. 2002. Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action. Antisense Nucleic Acid Drug Dev, 12(2): 103~128.
Margulies EH and Innis JW. 2000. eSAGE: managing and analysing data generated with serial analysis of gene expression (SAGE). Bioinformatics, 16(7): 650~651.
Markoff E, Henemyre C, Fellows J, Pennington E, Zeitler PS and Cedars MI. 1995. Localization of insulin-like growth factor binding protein-4 expression in the mouse uterus during the peri-implantation period. Biol Reprod, 53(5): 1103~1109.
Mathews DH, Sabina J, Zuker M and Turner DH. 1999. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol, 288(5): 911~140.
Matsumura H, Ito A, Saitoh H, Winter P, Kahl G, Reuter M, Kruger DH and Terauchi R. 2005. SuperSAGE. Cell Microbiol, 7(1): 11~18.
Matsumura H, Reich S, Ito A, Saitoh H, Kamoun S, Winter P, Kahl G, Reuter M, Kruger DH and Terauchi R. 2003. Gene expression analysis of plant host-pathogen interactions by SuperSAGE. Proc Natl Acad Sci U S A, 100(26): 15718~15723.
Maurer N, Fenske DB and Cullis PR. 2001. Developments in liposomal drug delivery systems. Expert Opin Biol Ther, 1(6): 923~947.
McRae RS, Johnston HM, Mihm M and O'Shaughnessy PJ. 2005. Changes in mouse granulosa cell gene expression during early luteinization. Endocrinology, 146(1): 309~317. Metivier R, Penot G, Hubner MR, Reid G, Brand H, Kos M and Gannon F. 2003.
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell, 115(6): 751~763.
Milner N, Mir KU and Southern EM. 1997. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat Biotechnol, 15(6): 537~541.
Mirkin S, Arslan M, Churikov D, Corica A, Diaz JI, Williams S, Bocca S and Oehninger S. 2005. In search of candidate genes critically expressed in the human endometrium during the window of implantation. Hum Reprod, 20(8): 2104~2117.
Morita K, Takagi M, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, Ishikawa T, Imanishi T and Koizumi M. 2003. Synthesis and properties of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) as effective antisense oligonucleotides. Bioorg Med Chem, 11(10): 2211~2226.
Munasinghe A, Patankar S, Cook BP, Madden SL, Martin RK, Kyle DE, Shoaibi A, Cummings LM and Wirth DF. 2001. Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes. Mol Biochem Parasitol, 113(1): 23~34.
Nakamura MT and Nara TY. 2004. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr, 24: 345~376.
Neilson L, Andalibi A, Kang D, Coutifaris C, Strauss JF, 3rd, Stanton JA and Green DP. 2000. Molecular phenotype of the human oocyte by PCR-SAGE. Genomics, 63(1): 13~24.
Ni H, Ding NZ, Harper MJ and Yang ZM. 2002. Expression of leukemia inhibitory factor receptor and gp130 in mouse uterus during early pregnancy. Mol Reprod Dev, 63(2): 143~150.
Ni H, Sun T, Ding NZ, Ma XH and Yang ZM. 2002. Differential expression of microsomal prostaglandin e synthase at implantation sites and in decidual cells of mouse uterus. Biol Reprod, 67(1): 351~358.
Nie G, Li Y, Wang M, Liu YX, Findlay JK and Salamonsen LA. 2005. Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility. Biol Reprod, 72(4): 1029~1036.
Nie GY, Li Y, Batten L, Griffiths B, Wang J, Findlay JK and Salamonsen LA. 2000. Uterine expression of alternatively spliced mRNAs of mouse splicing factor SC35 during early pregnancy. Mol Hum Reprod, 6(12): 1131~1139.
Nie GY, Li Y, Hampton AL, Salamonsen LA, Clements JA and Findlay JK. 2000. Identification of monoclonal nonspecific suppressor factor beta (mNSFbeta) as one of the genes differentially expressed at implantation sites compared to interimplantation sites in the mouse uterus. Mol Reprod Dev, 55(4): 351~363.
Nie GY, Li Y, Minoura H, Findlay JK and Salamonsen LA. 2003. Specific and transient up-regulation of proprotein convertase 6 at the site of embryo implantation and identification of a unique transcript in mouse uterus during early pregnancy. Biol Reprod, 68(2): 439~447.
Nie GY, Li Y, Wang J, Minoura H, Findlay JK and Salamonsen LA. 2000. Complex regulation of calcium-binding protein D9k (calbindin-D(9k)) in the mouse uterus during early pregnancy and at the site of embryo implantation. Biol Reprod, 62(1): 27~36.
Okada H, Sanezumi M, Nakajima T, Okada S, Yasuda K and Kanzaki H. 1999. Rapid down-regulation of CD63 transcription by progesterone in human endometrial stromal cells. Mol Hum Reprod, 5(6): 554~558.
Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM and Lieberman J. 2006. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature, 439(7072): 89~94.
Paria BC, Das SK, Andrews GK and Dey SK. 1993. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc Natl Acad Sci U S A, 90(1): 55~59.
Paria BC, Das SK and Dey SK. 1995. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A, 92(21): 9460~9464.
Paria BC, Huet-Hudson YM and Dey SK. 1993. Blastocyst's state of activity determines the "window" of implantation in the receptive mouse uterus. Proc Natl Acad Sci U S A, 90(21): 10159~10162.
Paria BC, Lim H, Wang XN, Liehr J, Das SK and Dey SK. 1998. Coordination of differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse. Endocrinology, 139(12): 5235~5246.
Paria BC, Reese J, Das SK and Dey SK. 2002. Deciphering the cross-talk of implantation: advances and challenges. Science, 296(5576): 2185~2188.
Paria BC, Song H, Wang X, Schmid PC, Krebsbach RJ, Schmid HH, Bonner TI, Zimmer A and Dey SK. 2001. Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation. J Biol Chem. 276(23): 20523~20528.
Parr EL, Tung HN and Parr MB. 1987. Apoptosis as the mode of uterine epithelial cell death during embryo implantation in mice and rats. Biol Reprod, 36(1): 211~225.
Passey RJ, Williams E, Lichanska AM, Wells C, Hu S, Geczy CL, Little MH and Hume DA. 1999. A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol, 163(4): 2209~2216.
Peng S, York JP and Zhang P. 2006. A transgenic approach for RNA interference-based genetic screening in mice. Proc Natl Acad Sci U S A, 103(7): 2252~2256.
Peters DG, Kassam AB, Yonas H, O'Hare EH, Ferrell RE and Brufsky AM. 1999. Comprehensive transcript analysis in small quantities of mRNA by SAGE-lite. Nucleic Acids Res, 27(24): e39.
Pleasance ED, Marra MA and Jones SJ. 2003. Assessment of SAGE in transcript identification. Genome Res, 13(6A): 1203~1215.
Poisson, j. p. g and Cunnane S. 1991. Long-chain fatty acid metabolism in fasting and diabetes: relation between altered desaturase activity and fatty acid composition J. Nutr. Biochem,. 2(2): 60~70.
Popovici RM, Kao LC and Giudice LC. 2000. Discovery of new inducible genes in in vitro decidualized human endometrial stromal cells using microarray technology. Endocrinology, 141(9): 3510~3513.
Porter DA, Krop IE, Nasser S, Sgroi D, Kaelin CM, Marks JR, Riggins G and Polyak K. 2001. A SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res, 61(15): 5697~702.
Powell J. 1998. Enhanced concatemer cloning-a modification to the SAGE (Serial Analysis of Gene Expression) technique. Nucleic Acids Res, 26(14): 3445~3446.
Raab G, Kover K, Paria BC, Dey SK, Ezzell RM and Klagsbrun M. 1996. Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor. Development, 122(2): 637~645.
Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M and Fisher SJ. 2004. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest, 114(6): 744~754.
Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN and Dey SK. 2001. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J Biol Chem, 276(47): 44137~44145.
Renfree MB and Shaw G. 2000. Diapause. Annu Rev Physiol, 62: 353~375.
Riddell SR, Elliott M, Lewinsohn DA, Gilbert MJ, Wilson L, Manley SA, Lupton SD, Overell RW, Reynolds TC, Corey L and Greenberg PD. 1996. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med, 2(2): 216~223.
Riesewijk A, Martin J, van Os R, Horcajadas JA, Polman J, Pellicer A, Mosselman S and Simon C. 2003. Gene expression profiling of human endometrial receptivity on days LH+2 versus LH+7 by microarray technology. Mol Hum Reprod, 9(5): 253~264.
Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Ratajczak CK and Moley KH. 2005. The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev Biol, 284(2): 377~386.
Robb L, Li R, Hartley L, Nandurkar HH, Koentgen F and Begley CG. 1998. Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med, 4(3): 303~308.
Ryo A, Kondoh N, Wakatsuki T, Hada A, Yamamoto N and Yamamoto M. 2000. A modified serial analysis of gene expression that generates longer sequence tags by nonpalindromic cohesive linker ligation. Anal Biochem, 277(1): 160~162.
Saha S, Sparks AB, Rago C, Akmaev V, Wang CJ, Vogelstein B, Kinzler KW and Velculescu VE. 2002. Using the transcriptome to annotate the genome. Nat Biotechnol, 20(5): 508~512.
Salamonsen LA, Nie G and Findlay JK. 2002. Newly identified endometrial genes of importance for implantation. J Reprod Immunol, 53(1~2): 215~225.
Santoro SW and Joyce GF. 1997. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci U S A, 94(9): 4262~4266.
Santoro SW and Joyce GF. 1998. Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry, 37(38): 13330~13342.
Sidhu SS and Kimber SJ. 1999. Hormonal control of H-type alpha(1-2)fucosyltransferase messenger ribonucleic acid in the mouse uterus. Biol Reprod, 60(1): 147~157.
Simmons DG and Kennedy TG. 2000. Induction of glucose-regulated protein 78 in rat uterine glandular epithelium during uterine sensitization for the decidual cell reaction. Biol Reprod, 62(5): 1168~1176.
Simmons DG and Kennedy TG. 2004. Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control. Reproduction, 127(4): 475~482.
Sledz CA, Holko M, de Veer MJ, Silverman RH and Williams BR. 2003. Activation of the interferon system by short-interfering RNAs. Nat Cell Biol, 5(9): 834~839.
Song H, Lim H, Das SK, Paria BC and Dey SK. 2000. Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. Mol Endocrinol, 14(8): 1147~1161.
Stachecki JJ and Armant DR. 1996. Transient release of calcium from inositol 1,4,5-trisphosphate-specific stores regulates mouse preimplantation development. Development, 122(8): 2485~2496.
Stark GR, Kerr IM, Williams BR, Silverman RH and Schreiber RD. 1998. How cells respond to interferons. Annu Rev Biochem, 67: 227~264.
Stern MD, Anisimov SV and Boheler KR. 2003. Can transcriptome size be estimated from SAGE catalogs? Bioinformatics, 19(4): 443~448.
Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Kontgen F and Abbondanzo SJ. 1992. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature, 359(6390): 76~79.
Summerton J. 1999. Morpholino antisense oligomers: the case for an RNase H-independent structural type. Biochim Biophys Acta, 1489(1): 141~158.
Sun XY, Li FX, Li J, Tan YF, Piao YS, Tang S and Wang YL. 2004. Determination of genes involved in the early process of embryonic implantation in rhesus monkey (Macaca mulatta) by suppression subtractive hybridization. Biol Reprod, 70(5): 1365~1373.
Svoboda P, Stein P and Schultz RM. 2001. RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA. Biochem Biophys Res Commun, 287(5): 1099-1104.
Tatsumi K, Higuchi T, Fujiwara H, Nakayama T, Fujii S and Fujita J. 2001. Expression of Ly-6A/E in the mouse uterus during implantation period. Mol Reprod Dev, 58(2): 159~165.
Tavernarakis N, Wang SL, Dorovkov M, Ryazanov A and Driscoll M. 2000. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet, 24(2): 180~183.
Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF and Dey SK. 2005. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A, 102(40): 14326~14331.
Tranguch S, Daikoku T, Guo Y, Wang H and Dey SK. 2005. Molecular complexity in establishing uterine receptivity and implantation. Cell Mol Life Sci, 62(17): 1964~1973.
Uil TG, Haisma HJ and Rots MG. 2003. Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities. Nucleic Acids Res, 31(21): 6064~6078.
Unneberg P, Wennborg A and Larsson M. 2003. Transcript identification by analysis of short sequence tags--influence of tag length, restriction site and transcript database. Nucleic Acids Res, 31(8): 2217~2226.
Ushizawa K, Herath CB, Kaneyama K, Shiojima S, Hirasawa A, Takahashi T, Imai K, Ochiai K, Tokunaga T, Tsunoda Y, Tsujimoto G and Hashizume K. 2004. cDNA microarray analysis of bovine embryo gene expression profiles during the pre-implantation period. Reprod Biol Endocrinol, 2(1): 77.
Velculescu VE, Zhang L, Vogelstein B and Kinzler KW. 1995. Serial analysis of gene expression. Science, 270(5235): 484~487.
Velculescu VE, Zhang L, Zhou W, Vogelstein J, Basrai MA, Bassett DE, Jr., Hieter P, Vogelstein B and Kinzler KW. 1997. Characterization of the yeast transcriptome. Cell, 88(2): 243~251.
Vilain C, Libert F, Venet D, Costagliola S and Vassart G. 2003. Small amplified RNA-SAGE: an alternative approach to study transcriptome from limiting amount of mRNA. Nucleic Acids Res, 31(6): e24.
Virlon B, Cheval L, Buhler JM, Billon E, Doucet A and Elalouf JM. 1999. Serial microanalysis of renal transcriptomes. Proc Natl Acad Sci U S A, 96(26): 15286~15291.
Wadehra M, Dayal M, Mainigi M, Ord T, Iyer R, Braun J and Williams CJ. 2006. Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. Dev Biol, 15;292(2):430~41.
Wadehra M, Forbes A, Pushkarna N, Goodglick L, Gordon LK, Williams CJ and Braun J. 2005. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Dev Biol, 287(2): 336~345.
Wang H and Dey SK. 2006. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet, 7(3): 185-199.
Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN and Dey SK. 2004. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med, 10(10): 1074~1080.
Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL and Dey SK. 2003. Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci U S A, 100(25): 14914~14919.
Wang H, Wang S, Nan L, Yu D, Agrawal S and Zhang R. 2002. Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. Int J Oncol, 20(4): 745~752.
Wang H, Xie H, Zhang H, Das SK and Dey SK. 2006. Conditional gene recombination by adenovirus-driven Cre in the mouse uterus. Genesis, 44(2): 51~56.
Wang J, Mayernik L, Schultz JF and Armant DR. 2000. Acceleration of trophoblast differentiation by heparin-binding EGF-like growth factor is dependent on the stage-specific activation of calcium influx by ErbB receptors in developing mouse blastocysts. Development, 127(1): 33~44.
Wang QT, Piotrowska K, Ciemerych MA, Milenkovic L, Scott MP, Davis RW and Zernicka-Goetz M. 2004. A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo. Dev Cell, 6(1): 133~144.
Wang Y and Guthrie C. 1998. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. RNA, 4(10): 1216~1229.
Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y and Kato S. 2001. A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J, 20(6): 1341~152.
Waterhouse P, Parhar RS, Guo X, Lala PK and Denhardt DT. 1992. Regulated temporal and spatial expression of the calcium-binding proteins calcyclin and OPN (osteopontin) in mouse tissues during pregnancy. Mol Reprod Dev, 32(4): 315~323.
Wei CL, Ng P, Chiu KP, Wong CH, Ang CC, Lipovich L, Liu ET and Ruan Y. 2004. 5' Long serial analysis of gene expression (LongSAGE) and 3' LongSAGE for transcriptome characterization and genome annotation. Proc Natl Acad Sci U S A, 101(32): 11701~11706.
Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND and Fuller-Pace FV. 2004. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol Biol, 5: 11.
Yamamoto M, Wakatsuki T, Hada A and Ryo A. 2001. Use of serial analysis of gene expression (SAGE) technology. J Immunol Methods, 250(1~2): 45-66.
Yang YJ, Liu WM, Zhou JX, Cao YJ, Li J, Peng S, Wang L, Yuan JG and Duan EK. 2006. Expression and hormonal regulation of calcyclin-binding protein (CacyBP) in the mouse uterus during early pregnancy. Life Sci, 78(7): 753~760.
Ye SQ, Lavoie T, Usher DC and Zhang LQ. 2002. Microarray, SAGE and their applications to cardiovascular diseases. Cell Res, 12(2): 105~115.
Yoon SJ, Choi DH, Lee WS, Cha KY, Kim SN and Lee KA. 2004. A molecular basis for embryo apposition at the luminal epithelium. Mol Cell Endocrinol, 219(1-2): 95~104.
Yoshinaga K and Adams CE. 1966. Delayed implantation in the spayed, progesterone treated adult mouse. J Reprod Fertil, 12(3): 593~595.
Yoshioka K, Matsuda F, Takakura K, Noda Y, Imakawa K and Sakai S. 2000. Determination of genes involved in the process of implantation: application of GeneChip to scan 6500 genes. Biochem Biophys Res Commun, 272(2): 531~538.
Zamecnik PC and Stephenson ML. 1978. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci U S A, 75(1): 280~284.
Zamore PD. 2002. Ancient pathways programmed by small RNAs. Science, 296(5571): 1265~1269.
Zamore PD, Tuschl T, Sharp PA and Bartel DP. 2000. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101(1): 25~33.
Zeng F, Baldwin DA and Schultz RM. 2004. Transcript profiling during preimplantation mouse development. Dev Biol, 272(2): 483~496.
Zhang L, Gasper WJ, Stass SA, Ioffe OB, Davis MA and Mixson AJ. 2002. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res, 62(19): 5463~5469.
Zhang L, Zhou W, Velculescu VE, Kern SE, Hruban RH, Hamilton SR, Vogelstein B and Kinzler KW. 1997. Gene expression profiles in normal and cancer cells. Science, 276(5316): 1268~1272.
Zhu LJ, Bagchi MK and Bagchi IC. 1998. Attenuation of calcitonin gene expression in pregnant rat uterus leads to a block in embryonic implantation. Endocrinology, 139(1): 330~339.
Zolfaghari R and Ross AC. 2003. Recent advances in molecular cloning of fatty acid desaturase genes and the regulation of their expression by dietary vitamin A and retinoic acid, Prostaglandins Leukot Essent Fatty Acids, 68(2): 171~179.