北京地区妇女对HPV病毒与宫颈病变认知程度的调查研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
宫颈癌是威胁妇女健康最为严重的疾病。宫颈上皮内瘤变是发生在癌前的病变,称为宫颈癌前病变或宫颈病变。人乳头状瘤病毒(HPV)是引起宫颈癌发生的主要病因。一般宫颈病变的转变过程很长,大约是十年,这个过程当中只要能及时发现问题,确诊宫颈恶变细胞的存在,及时对症治疗就能起到根治的作用。宫颈癌的防治重点目前仍是及时发现并积极治疗癌前病变,同时预防和消除HPV感染,因此宫颈病变的筛查被赋予及其重要的意义。妇女对宫颈病变的认知程度决定了其对宫颈病变的防治参与的积极性,故现对北京妇女对宫颈病变的认知程度进行调查研究。
     目的:研究分析北京地区妇女对HPV及宫颈病变的认知程度,并探讨影响因素。
     方法:随机抽取调查对象,记录一般情况,包括姓名、年龄、职业、文化程度、月经情况、孕产情况。采用调查问卷形式,设立HPV及宫颈病变相关知识选择题若干,由被调查者选择。将数据输入计算机,进行统计。
     结果:北京地区妇女对HPV及宫颈病变认知程度较低,文化程度是其中的影响因素之一。
     结论:加强健康教育、宣传筛查的必要性,尤其对文化程度偏低的妇女,是预防宫颈癌工作的重要环节。
Cervical cancer is the most serious threat to women's health. Cervical intraepithelial neoplasia occurred in precancerous lesions, known as cervical cancer or precancerous pathological changes of the cervix. Human papilloma virus (HPV) is the major cause of the cervical cancer. The process of the general cervical lesions is about 10 years. It can promptly identify problems in this process, confirm the presence of cervical malignant cells, cure the disease as soon as possible. The focus of the cervical cancer prevention is still be detected timely, treated the precancerous lesions positively, prevented and eliminated the HPV infection. So the scanning of the cervical lesions has been very important. Women's awareness of cervical lesions determined whether they were positive or not in the prevention and treatment of cervical lesions. Hence the research of the Beijing women's awareness of cervical lesions has be done.
     Objective: To study the women of Beijing know HPV and cervical lesions on the cognitive level, and to explore the factors of it.
     Methods: Choose the sample randomly; record the general information, including name, age, occupation, education, periods and pregnancy. Use the questionnaire forms, establish some multiple-choice questions of HPV and cervical lesions, let the respondents choose,and then put all the information into the computer to be statistic.
     Results: The awareness of women in Beijing on HPV and cervical lesions is very low; literacy is one of the affected factors.
     Conclusion: It is very important to strengthen health education and screen the need for publicity, particularly for the low educational women, for preventing the cervical cancer.
引文
[1] 罗元恺.女科述要.新中医,1992,25(9):19-20.
    [2] 杨利侠.带下病治疗之我见.时珍国医国药,2007,18(11):2845-2846.
    [3] 李婴.知柏地黄丸加减治疗带下病 57 例.实用中医内科杂志,2007,21(3):75.
    [4] 薛守宇. 武权生教授治疗妇科炎症经验举隅. 山西中医学院学报,2007,8(1):31-32.
    [5] 冀绪.浅谈带脉理论在带下病中的作用.河北中医,1997,19(2):33-34.
    [6] 苏 玉 梅 . 易 黄 汤 加 味 内 外 兼 治 带 下 证 236 例 . 宁 夏 医 学 杂志,2006,28(12):973-974.
    [7] 徐洁.止带汤治疗带下病 128 例对照观察. 浙江中西医结合杂志,2007,17(12): 772-773.
    [8] 向武平.中医辨证分型治疗带下病 40 例临床分析.中外健康文摘,2007,4(7):855
    [9] 索俊玲.龙胆泻肝汤妇科应用举隅. 山东中医杂志,2007.26(2):134-135.
    [10] 张玉华.妇科带下症 50 例的中医治疗. 职业与健康,2004,20(1):124-125.
    [11] 杨会华.中西医结合治疗妇科尖锐湿疣 60 例.社区医学杂志,2006,4(9):34-35.
    [12] 张岩.中西医结合治疗尖锐湿疣 68 例.实用中西医结合临床,2005,5(3):58-59.
    [13] 李爱芳.中西医结合治疗尖锐湿疣临床观察.第四军医大学学报,2006,27(14):1327-1328.
    [14] 索世云.中西医综合治疗尖锐湿疣 57 例.中国医药导报,2007,4(9):96.
    [15] 郑萍.中西医结合治疗对尖锐湿疣复发的观察.四川中医,2006,24(10):71.
    [16] 丁杨峰.CO2 激光结合中药熏洗治疗巨大尖锐湿疣.临床皮肤科杂志,2006,35(8):544.
    [17] 金哲. 清毒栓治疗宫颈人乳头瘤病毒感染的临床研究.中国中西医结合杂志,2002,22(10):735-737.
    [18] 韩凤娟. 宫颈上皮内瘤变中西医治疗近况.中医药学报,2006,34(1):32-34.
    [19] 关素洁.宫颈癌的发病机制及中医药治疗研究进展.中医药导报,2007,13(2):95-96.
    [20] 黄志欣.中药保妇康拴在 HPV 感染宫颈病变患者中的应用研究.中国医师杂志,2007,9(8):1128-1130.
    [21] 张 燕 . 女 性 生 殖 道 人 乳 头 状 瘤 病 毒 感 染 的 治 疗 . 中 国 感 染 与 化 疗 杂志,2007,7(4):293-294.
    [22] 张国珍喷涂中药治疗宫颈癌前病变及原位癌 96 例疗效观察.河北中医,2006,28(11):819-820.
    [23] 郑玉兰中药锥切疗法治疗宫颈非典型增生附 38 例分析.航空航天医药,2006,11(3):150-151.
    [24] 张鹏霞.女贞子血清药理对 Hela 细胞增殖抑制的实验研究.黑龙江医药科学,2004,27(5):15-16.
    [25] 孟昭影.消疣液体外抗尖锐湿疣皮损中 HPV 的研究.中国皮肤性病学杂志,2007,21(2):103-104.
    [1] Zur HH. Pap illomavirus in human cancer. Cancer,1987,59(10):1692-1696.
    [2] lombard I,Vincent-Salomon A,Validier,et al Human pap illomvirus genotype as a majoy determ inant of the of cervical J Clin Oncol,1998,16(8):2613-2619.
    [3] Munoz N.Human pap illomavirus and cancer .the epidemiological evidence.J Clin Virol,2000,19(1):1-4.
    [4] Franco EL.Duarate-francoE.ferenczy.Cervical cancer epidemiological preventio- n and the role of human papillomavirus infection. CMAJ,2001,164(7):1017-1025.
    [5] 李力.宫颈癌与人乳头瘤病毒感染.中国实用妇科与产科杂志,2006,22(1),13-15.
    [6] 潘凌亚.HPV 感染与宫颈癌前病变.基础医学与临床,2006,26(12):1296-1301.
    [7] Damin AP , Karam R , Zettler CG, et al. Evidence for an Association of Human Pap illomavirus and Breast Carcinomas .Breast Cancer Res Treat , 2004 , 84 : 131-137.
    [8] Gillison ML , Shah KV. Human Pap illomavirus Associated Head and Neck Squamous Cell Carcinoma : Mounting Evidence for an Etiologic Role for Human Pap illomavirus in a Subset of Head and Neck Cancers. Curr Opin Oncol , 2001,13 : 183-188.
    [9] zur Hausen H. Pap illomaviruses Causing Cancer : Evasion from Host Cell Control in Early Events in Carcinogenesis. J Natl Cancer Inst , 2000 , 92 : 690-698
    [10] MARGARET E C. The role of human pap illomavirus in riskmanagement . Gynecol Prac ,2003 ,3 (3) :229-233.
    [11] zur Hausen H. Pap illomaviruses and cancer: From basis studies to clinical app lication. Nut Rev Cancer, 2002,2: 342 - 350.
    [12] MunozN, Bosch FX, de Sanjose S, et al. Ep idemiologic classification of human pap illomavirus types associated with cervical cancer.N Engl J Med, 2003, 348 (6) : 518-527.
    [13] An HJ, Cho NH, Lee SY, et al. Correlation of cervical carcinoma and precancerous lesionswith human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method. Cancer, 2003, 97 (7) : 1672-1680.
    [14] Hwang TS, Jeong JK, ParkM, et al. Detection and typing of HPV genotypes in various cervical lesions by HPV oligonucleotide microarray. Gynecol Oncol, 2003 , 90 (1) : 51-56.
    [15] 沈艳红, 陈凤, 黄曼妮, 等. 我国山西省子宫颈癌高发区人乳头瘤病毒感染调查. 中国医学科学院学报,2003, 25: 381 - 385.
    [16] 陈凤. 第二代杂交捕获法检测子宫颈癌人乳头瘤状病毒影响因素的研究.中华医学杂志,2005,85(2):129-130
    [17] Peyton CL, Gravitt PE, HuntWC, et al. Determinants of genital human pap illomavirus detection in a US population . J InfectDis,2001,183:1554-1564.
    [18] Sellors JW, Karwalajtys TL, Kaczorowski JA, et al. Prevalence of infection with carcinogenic human papillomavirus among olderwomen.CMAJ,2002,167:871-873.
    [19] Baldwin SB, Wallace DR, PapenfussMR, et al. Human pap illomavirus infection in men attending a sexually transmitted disease Clinic . J Infect Dis, 2003, 187: 1064- 1070.
    [20] 程晓东,谢幸. 女性生殖道人乳头瘤病毒感染的流行病学.实用妇产科杂志,2004,20(2):65-66.
    [21] 朱一剑等. 妇科疾病中人乳头瘤病毒感染的分子流行病学调查.中国妇幼保健,2007,19(22):2691-2694.
    [22] Velema JP,Ferrer A,Figueroa M etal.Burning wood in the kitchen increases the risk of cervical neoplasia in HPV-infected women in Honduras Int J Cancer,2002,97(4):536-541.
    [23] Moscicki AB,Hills N,Shiboski S,etal.Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females.JAMA,2001,285:2995-3002.
    [24] 陈强. HIV阳性人群中HPV感染的研究进展. 国外医学皮肤性病学分册,2004,30(3):194-196.
    [25] 杨华等. 女性生殖道人乳头瘤病毒感染相关因素分析. 中国妇幼保健, 2007,22(20):2825-2826
    [26] 王桂芳等.女性生殖道人乳头瘤病毒16和18型感染的危险因素分析,吉林大学学报,2002,28(1):108-110
    [27] 杨华. 人乳头瘤病毒与女性生殖道病原体感染相关性分析. 国际流行病学传染病学杂志,2007,34(2):88-90
    [28] 王薇,马丁.人乳头瘤病毒感染对青少年女性的影响. 中国妇幼健康研究, 2006,17(5):436-438
    [29] 杨杰等. HPV 感染和bcl-2、P53基因产物在宫颈癌组织中表达及其意义.陕西医学杂志,2007,36(3):305-307.
    [30] Ip SM, Huang T G, YeungW S, et al. pRb expressing adenovirus Ad5 Rb attenuates the p53 induced apoptosis in cervical cancer cell lines. Eur J Cancer, 2001, 37 (18) : 2475 - 2483.
    [31] 王喜梅等. 子宫颈腺癌中HPV16 /18感p16Ink4a 、Rb蛋白表达的影响.临床与实验病理学杂志,2006,22(3):320-324.
    [32] Crish JF,BoneF,Balasubramanian S, et al. Sup rabasal expression of the human pap iliomavirus type 16 oncoproteins in mouse epidermis alters expression of cycle regulatory proteins. Carcinogenesis, 2000, 21: 1031-1037。
    [33] 王喜梅等.宫颈腺癌中HPV 感染与Skp2、p27kip1蛋白表达的研究.中国现代医学杂志,2006,16(15):2301-2305.
    [34] 赵富玺等. 宫颈上皮内肿瘤及宫颈鳞状细胞癌组织中HPV16感染与hTERT、p21waf1和Ki67表达的关系及意义.2005,19(4):370-374.
    [35] Ansari2LariM A, StaeblerA, Zaino R J, et al. Distinction of endo-cervical and endometrial adenocarcinomas: immunohisto chemical p16 expression correlated with human pap illomavirus (HPV) DNA detection. Am J Surg Pathol, 2004 , 28 (2) : 160 - 167.
    [36] 董磊,宋张娟. 宫颈鳞癌中p16、p21WAF1、Rb、cyclinE蛋白的表达.临床与实验病理学杂志,2004,20(5):554-556.
    [37] 童锦禄,冉志华.G1/S检测点调控机制研究进展.世界华人消化杂志,2005,13: 2036-2039.
    [38] 庞月华,张新平,冯义伯,等. 细胞周期及其调控研究进展. 新疆医科大学学报, 2005, 28: 596-597.
    [39] Boutros R, Dozier C, Ducommun B. The when and where od CDC25 phosphatases. Curr Op in Cell Biol, 2006,18: 185-191.
    [40] 戴淑真等. 外源性人乳头瘤病毒16型E7癌基因导入对HeLa细胞cdc25A表达的影响.现代妇产科进展,2006,15(11):844-846.
    [41] 胡红波等.宫颈上皮内瘤变组织人乳头瘤病毒感染与凋亡抑制基因表达的相关性研究.中国结合临床,2006,22(1):71-73.
    [42] KU J H ,KWA K C ,L EE H S ,et al . Expression of survivin , a novel inhibitor of apoptosis , in superficial transitional cell carcinoma of t he bladder. J Urol ,2004 ,171 (2 Pt 1) :631-635.
    [43] SHIN S ,SUNGBJ ,CHO YS ,et al . An antiapoptotic protein human survivin is a direct inhibitor of caspase23 and 27 .Biochemistry ,2001 ,40 (4) :1117-1123.
    [44] 王喜梅等.PTEN 和survivin 在宫颈腺癌中的表达及其与HPV16/ 18 感染的关系.肿瘤,2006,26(9):847-850.
    [45] KloosDU, Choi C,Wingender E. The TGF-beta-Smad network: introducing bioinformatic tools. Trends Genet,2002, 18∶96-103.
    [46] Hazelbag S, Gorter A, Kenter GG, et al. Transforming growth factor-beta1 induces tumor stroma and reduces tumor infiltrate in cervical cancer. Hum Pathol,2002, 33∶1193-1199.
    [47] Ngan HY, Cheung AN,L iu SS, et al. Abnormal expression of panras, c-myc and p53 in squamous cell carcinoma of cervix: correlation with HPV and prognosis. Oncol Rep, 2001, 8∶557-561.
    [48] Lee DK, Kim BC, Kim IY, et al. The human pap illoma virus E7 onco-protein inhibits transforming growth factor-beta signaling by blocking binding of the Smadcomplex to its target sequence. J Biol Chem, 2002, 11; 277 ∶38557-38564.
    [49] 俞海等.Notch途径与宫颈癌细胞系的增殖调控.生命的化学,2006,26(4):355-357.
    [50] 牛小红.ET-1、ETA-R在宫颈癌中的表达与HPV感染的关系.现代妇产科进展,2006,15(11):838-841.
    [51] 郎景和. 迎接子宫颈癌预防的全球挑战与机遇. 中华妇产科杂志, 2002, 37 (3) : 1292-1311.
    [52] Hesselink AT , van2den2Brule AJ , Brink AA , et al . Comparison ofhybrid capture 2 with in sit u hybridization for t he detection of high risk human papillomavirus in liquid based cervical samples. Cancer ,2004 , 102 (1) : 11-18.
    [53] Player AN , Shen LP , Kenny D , et al . Single copy gene detection using branched DNA ( bDNA) in situ hybridization. J Histochem Cytochem , 2001 , 49 (5) : 603-612.
    [54] Pretet JL , Dalstein V , Monnier Benoit S , et al . High risk HPV load estimated by Hybrid Capture II correlates with HPV16 load measured by real2time PCR in cervical smears of HPV162infectedwomen. J Clin Virol , 2004 , 31 (2) : 140-147.
    [55] Castle PE , Schiffman M , Burk RD , et al . Rest ricted cross reactivity of hybrid capture 2 with nononcogenic human papillomavirus types. Cancer Epidemiol Biomarkers Prev , 2002 , 11 ( 11) : 1394-1399.
    [56] Castle PE , Lorincz AT , Scott DR , et al . Comparison between prototype hybrid capture 3 and hybrid capture 2 human papillomavirusDNA assays for detection of high grade cervical intra epithelial neoplasia and cancer . J Clin Microbiol , 2003 , 41 (9) : 4022-4030.
    [57] 何桂蓉等.人乳头瘤病毒感染分子诊断的研究进展. 中华检验医学杂志,2006,29(11):1048-1049.
    [58] 颜丹等.荧光定量聚合酶链反应检测人乳头瘤病毒的实验研究.现代预防医学,2006,33(11):2059-2060.
    [59] An HJ , Cho NH , Lee SY, et al . Correlation of cervical carcinomaand precancerous lesions wit h human papillomavirus ( HPV) genotypes detected with the HPV DNA chip micro-array method. Cancer , 2003 , 97 (7) : 1672-1680.
    [60] Kim CJ , J eong J K, Park M , et al . HPV oligonucleotide micro-array based detection of HPV genotypes in cervical neoplastic lesions. Gynecol Oncol , 2003 , 89 (2) : 210-217.
    [61] 陶萍萍等. 导流杂交与杂交捕获二代用于生殖道人乳头状瘤病毒感染诊断的比较研究.中国实用妇科与产科杂志,2006,22(5):355-357.
    [62] 陶萍萍等.导流杂交基因芯片技术在人乳头状瘤病毒检测中应用的研究.中国妇产科杂志,2006,41(1):43-47.
    [63] 赵建等. 导流杂交基因芯片技术在人乳头状瘤病毒感染分型检测中的临床应用.中华检验医学杂志,2006,29(12):1148-1151.
    [64] 范江涛. 人乳头瘤病毒负荷量与宫颈上皮内瘤样病变的关系.广西医科大学学报,2006,23(2):262-263
    [65] Schlecht NF , Trevisan A , Franco ED , et al. Viral load as a predictor of the risk of cervical intraepithelial neoplasia. Int J Cancer , 2003 , 103 (4) :519-524.
    [66] Sun CA , Liu J F , Wu DM , et al. Viral load of high-risk human papillomavirus in cervical squamous intraepithelial lesions. Int J Gynecol Obstet , 2002 , 76 (1) :41-47.
    [67] 尚春霞等. 干扰素不同途径给药治疗宫颈SPI的疗效比较.中国妇幼保健,2006,22:181-182.
    [68] Zhou J , Sun XY, StenzelDJ , et al. Expression of vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion like particles[ J ]. Virology, 1991, 185 (1) : 251 - 257.
    [69] Evans TG,Bonnez W ,Rose RC,et a1.A phase I study of a recombinant virus like particle vaccine against human papillomavirus type 11 in healthy adult volunteers J Infect Dis,2001,183:1485-1493.
    [60] Koutsky LA, Ault KA, Wheeler CM, et al. A controlled trial of a human pap illomavirus type 16 vaccine. N Engl J Med, 2002, 347:1645-1651.
    [71] Brown DR,Bryan JT,Schroeder JM ,et a1.Neutralization of human pap illomavirus type 11(HPV一11)by serum from women vaccinated with yeast-derived HPV一11 L1 vlrus-like particles:correlation with competitive radlo immunoassay titer.J Inlet Dis,2001,184:1183-1186.
    [72] Pinto LA, Edwards J, Castle PE, et al. Cellular immune responses to human pap illomavirus ( HPV ) 216 L1 in healthy volunteers immunized with recombinant HPV216 L1 virus2like particles. J Infect Dis, 2003, 188: 327-338.
    [73] Ault KA, Giuliano AR, Edwards RP, et al. A phase Ⅰ study to evaluate a human pap illomavirus (HPV) type 18 L1 VLP vaccine.Vaccine, 2004, 22: 3004-3007.
    [74] HarperDM, Franco EL, Wheeler C, et al. Efficacy of a bivalentL1virus-like particle vaccine in prevention of infection with human pap illomavirus types 16 and 18 in young women: a randomized controlled trial. Lancet, 2004, 364: 1757-1765.
    [75] Villa LL, Costa RL, Petta CA, et al. Prophylactic quadrivalent human pap illomavirus ( types 6, 11, 16, and 18 ) L1 virus-like particle vaccine in young women: a randomized double-blind p lacebo-controlled multicentre phase Ⅱ efficacy trial. LancetOncol,2005, 6: 271-278.
    [76] 乔友林.子宫颈癌预防研究的里程碑.基础医学与临床,2006,26(12):1293-1295.
    [77] 范江涛等. 人乳头瘤病毒的致癌机理及其疫苗的临床试验研究.国外医学病毒学分册,2005,12(5):133-136.
    [78] 张颖、郎景和. 人乳头状瘤病毒疫苗在子宫颈病变预防与治疗中的应用.中华妇产科杂志,2006,41(3):214-216.
    [79] 郭晓红, 周忠孝. 转录后水平的基因沉默-RNA干涉. 基础医学与临床, 2003, 23: 24 - 29.
    [80] 危敏等.siRNA抑制HPV 18 E 6基因及其对HeLa细胞凋亡的影响.基础医学与临床,2006,26(10):1112-1117.
    [81] 成海恩等.HPV216 E6基因沉默对宫颈癌CaSki细胞的影响.第四军医大学学报,2006,27(20):1888-1891.
    [82] 杨改珍. 已婚妇女对宫颈细胞学检查认知程度的调查分析. 护理研究,2007, 21(3):769-770
    [83] Mc Caffery K, Forrest S, Waller J, etal. Attitudes towards HPV testing: a qualitative study of beliefs among Indian, Pakistani, African - Caribbean and white British women in the UK. Br Cancer, 2003, 88 (1) : 42-44.
    [84] Mc Caffery K, Waller J , Forrest S, et al. Testing positive for human pap illomavirus in routine cervical screening: examination of p sychosocial impact. BJOG, 2004, 111 (12) : 1437-1440.
    [1] 章文华,李南,吴令英。重视宫颈癌患者年轻化的趋势.浙江肿瘤 2000,6(2):112-114.
    [2] Adersson S ,Rylander E ,Larsson B ,etal,The role of human papillomavirus in cervical carcinoma carcinogenesis .European Cancer,2001,37:246-250.
    [3] 王苏梅.HPV 感染妇女心理健康状况初步调查.黑龙江医药科学,2005,28(3):18-19.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700