温和灸治疗慢性盆腔炎临床观察及对其免疫功能影响的研究
|
摘要
目的
慢性盆腔炎是妇科常见病、多发病,其发病率有逐年上升的趋势,因病情较顽固,病程较长,常久治不愈,严重影响了妇女的身心健康和正常生活,给家庭及社会造成了较大的负担。一般的临床治疗见效慢、远期效果欠佳、复发率高。针灸治疗本病独具特色,疗效肯定。本课题采用温和灸治疗慢性盆腔炎,在临床观察的基础上,检测患者治疗前后外周血免疫球蛋白、T淋巴细胞亚群的变化,探讨温和灸治疗慢性盆腔炎的作用机理,为艾灸治疗本病提供科学的实验依据。
方法
60例患者均为湖北省丹江口市第一医院针骨科和妇科住院病人,符合慢性盆腔炎诊断标准。按照随机数字表,将患者分为观察组和对照组。观察组30例,采用温和灸治疗,取穴:关元、中极、子宫、阴陵泉(双)、足三里(双)、三阴交(双)。取华佗牌清艾条(苏州医疗用品厂)1支,将艾条的一端点燃,对准施灸部位,约距15～25mm左右进行熏灸,使患者局部有温热感而无灼痛为度,每穴灸5分钟。上述方法于月经干净后开始治疗,每日1次,经期停灸。对照组30例,采用口服妇科千金片治疗,每次6片,1日3次,温水吞服。2个月后评定疗效。患者治疗前及治疗结束后,空腹抽取肘静脉血4ml,分别检测血清免疫球蛋白、外周血T淋巴细胞亚群含量。结果
1.观察组治愈率为43.3%,总有效率为96.6%;对照组治愈率为23.3%,总有效率为76.7%。观察组治愈率及总有效率明显优于对照组,经统计学处理,有显著性差异(P＜0.05)。
2.两组治疗前后症状积分的比较,观察组和对照组治疗前后症状积分均明显降低(P＜0.01),但观察组降低更显著,与对照组比较,有极显著性差异(P＜0.01)。表明观察组在改善患者症状方面优于对照组。
3.治疗前观察组和对照组血清IgG、IgA、IgM比较,无显著性差异(P＞0.05)。治疗后两组患者血清IgG、IgA含量均呈上升趋势,但观察组明显上升(P＜0.01),与对照组比较,有显著性差异(P＜0.05);治疗后两组患者血清IgM含量均呈上升趋势,与治疗前比较,仅观察组有显著性差异(P＜0.05)。
4.治疗前治疗组与对照组各项指标比较,均无显著性差异,表明两组患者具有可比性。治疗后两组CD_3~+、CD_4~+、CD_4~+/CD_8~+均呈升高趋势,但观察组显著升高,与治疗前比较,经统计学处理,有极显著性差异(P＜0.01),与对照组比较,有显著性差异(P＜0.05)。治疗后两组CD_8~+含量均呈下降趋势,但观察组明显降低,与对照组比较,有显著性差异(P＜0.05)。
结论
1.温和灸治疗慢性盆腔炎,临床疗效显著,明显优于对照组。
2.温和灸在改善慢性盆腔炎患者症状方面明显优于对照组。
3.艾灸能显著调节慢性盆腔炎患者血清免疫球蛋白及外周血T淋巴细胞亚群含量,提高机体的免疫功能,这可能是艾灸治疗本病的作用机理之一。
Objectives
Chronic pelvic inflammatory disease is a common and frequently occurring gynecology disease,its incidence is increasing year by year,the trend because of a stubborn illness,longer course,patients often has seriously complaint of the physical and mental health of women and a normal life,it has been a greater burden of the family and the community.The general clinical results slow,long-term effects of poor,high recurrence rate.acupuncture and moxibustion treatment has a unique effective,we used warming moxibustion treatment of chronic pelvic inflammatory disease,on the basis of clinical observation,through observation before and after treatment,we detected the contents of peripheral blood Immunoglobulin and T lymphocyte subgroup,so as to approach the mechanism of action of treat chronic pelvic inflammatory disease by warming moxibustion.
Methods
sixty patients were selected from the department of Acupuncture and orthopaedics of Danjiangkou NO.1 hospital of Hubei province,they were all consistent with Chronic pelvic inflammatory disease diagnostic criteria.All the cases were randomly divided into two groups,observation group and control group,each group was thirty.Observation group adopts warming moxibustion treatment on Guanyuan,Zhongji,Zigong,Yinlingquan,Zusanli, Sanyinjiao acupionts.Three to five minutes one acupoint,one time a day and suspension between menstruation,control group adopted gynecology Qianjin pill for oral use,six pills one time and three times one day.After two months treatment,we evaluated the clinical therapeutic effect and detected the variation of the contents of peripheral blood Immunoglobulin and T lymphocyte subgroup.
Results
1.Healing rate and total effective rate of observation group is 43.3%and 96.6%respectively,but control group's healing rate is 23.3%and it's total effective is 76.7%.this shows that observation group is more excellent than control group in curative effect(P＜0.05).
2.Warming moxibustion treatment can improve patien's symptoms obviously(P＜0.01),compared with control group,there is omly a wild improvement in cardinal symptoms(P＜0.01).
3.The contents of blood serum IgG、IgA、IgM in two groups pretherapy are nearly equivalency.After treatment,the contents of blood serum IgG、IgA showed an upward trend,While the content was obviously higher in observation group(P＜0.01),compared with control Group,the statistical comparison shows a significant difference(P＜0.05).After treatment,the contents of blood serum IgM showed an upward trend,compared with pretherapy,observation group has a significant difference(P＜0.05) merely.
4.After treatment,the contents of blood serum CD_3~+、CD_4~+、CD_4~+/CD_8
showed an upward trend,While the content was obviously higher in observation group(P＜0.01),compared with control Group,the statistical comparison shows a significant difference(P＜0.05).After treatment,the contents of blood serum CD_8~+ showed a downward trend,However,the observation group decreased significantly(P＜0.01 );compared with the control group,there was a significant difference(P＜0.05).
Conclusion
1.The clinical curative effect of chronic pelvic inflammatory by using warming moxibustion treatment is predominance,which is superior than control group obviously.
2.Warming moxibustion treatment can improve patien's symptoms obviously,which is superior than control group obviously.
3.warming moxibustion can accommodate the contents of peripheral blood Immunoglobulin and T lymphocyte subgroup on chronic pelvic inflammatory patients,improve organism immune function,it is a possible mechanism of treatment the disease by warming moxibustion.
慢性盆腔炎是妇科常见病、多发病,其发病率有逐年上升的趋势,因病情较顽固,病程较长,常久治不愈,严重影响了妇女的身心健康和正常生活,给家庭及社会造成了较大的负担。一般的临床治疗见效慢、远期效果欠佳、复发率高。针灸治疗本病独具特色,疗效肯定。本课题采用温和灸治疗慢性盆腔炎,在临床观察的基础上,检测患者治疗前后外周血免疫球蛋白、T淋巴细胞亚群的变化,探讨温和灸治疗慢性盆腔炎的作用机理,为艾灸治疗本病提供科学的实验依据。
方法
60例患者均为湖北省丹江口市第一医院针骨科和妇科住院病人,符合慢性盆腔炎诊断标准。按照随机数字表,将患者分为观察组和对照组。观察组30例,采用温和灸治疗,取穴:关元、中极、子宫、阴陵泉(双)、足三里(双)、三阴交(双)。取华佗牌清艾条(苏州医疗用品厂)1支,将艾条的一端点燃,对准施灸部位,约距15～25mm左右进行熏灸,使患者局部有温热感而无灼痛为度,每穴灸5分钟。上述方法于月经干净后开始治疗,每日1次,经期停灸。对照组30例,采用口服妇科千金片治疗,每次6片,1日3次,温水吞服。2个月后评定疗效。患者治疗前及治疗结束后,空腹抽取肘静脉血4ml,分别检测血清免疫球蛋白、外周血T淋巴细胞亚群含量。结果
1.观察组治愈率为43.3%,总有效率为96.6%;对照组治愈率为23.3%,总有效率为76.7%。观察组治愈率及总有效率明显优于对照组,经统计学处理,有显著性差异(P＜0.05)。
2.两组治疗前后症状积分的比较,观察组和对照组治疗前后症状积分均明显降低(P＜0.01),但观察组降低更显著,与对照组比较,有极显著性差异(P＜0.01)。表明观察组在改善患者症状方面优于对照组。
3.治疗前观察组和对照组血清IgG、IgA、IgM比较,无显著性差异(P＞0.05)。治疗后两组患者血清IgG、IgA含量均呈上升趋势,但观察组明显上升(P＜0.01),与对照组比较,有显著性差异(P＜0.05);治疗后两组患者血清IgM含量均呈上升趋势,与治疗前比较,仅观察组有显著性差异(P＜0.05)。
4.治疗前治疗组与对照组各项指标比较,均无显著性差异,表明两组患者具有可比性。治疗后两组CD_3~+、CD_4~+、CD_4~+/CD_8~+均呈升高趋势,但观察组显著升高,与治疗前比较,经统计学处理,有极显著性差异(P＜0.01),与对照组比较,有显著性差异(P＜0.05)。治疗后两组CD_8~+含量均呈下降趋势,但观察组明显降低,与对照组比较,有显著性差异(P＜0.05)。
结论
1.温和灸治疗慢性盆腔炎,临床疗效显著,明显优于对照组。
2.温和灸在改善慢性盆腔炎患者症状方面明显优于对照组。
3.艾灸能显著调节慢性盆腔炎患者血清免疫球蛋白及外周血T淋巴细胞亚群含量,提高机体的免疫功能,这可能是艾灸治疗本病的作用机理之一。
Objectives
Chronic pelvic inflammatory disease is a common and frequently occurring gynecology disease,its incidence is increasing year by year,the trend because of a stubborn illness,longer course,patients often has seriously complaint of the physical and mental health of women and a normal life,it has been a greater burden of the family and the community.The general clinical results slow,long-term effects of poor,high recurrence rate.acupuncture and moxibustion treatment has a unique effective,we used warming moxibustion treatment of chronic pelvic inflammatory disease,on the basis of clinical observation,through observation before and after treatment,we detected the contents of peripheral blood Immunoglobulin and T lymphocyte subgroup,so as to approach the mechanism of action of treat chronic pelvic inflammatory disease by warming moxibustion.
Methods
sixty patients were selected from the department of Acupuncture and orthopaedics of Danjiangkou NO.1 hospital of Hubei province,they were all consistent with Chronic pelvic inflammatory disease diagnostic criteria.All the cases were randomly divided into two groups,observation group and control group,each group was thirty.Observation group adopts warming moxibustion treatment on Guanyuan,Zhongji,Zigong,Yinlingquan,Zusanli, Sanyinjiao acupionts.Three to five minutes one acupoint,one time a day and suspension between menstruation,control group adopted gynecology Qianjin pill for oral use,six pills one time and three times one day.After two months treatment,we evaluated the clinical therapeutic effect and detected the variation of the contents of peripheral blood Immunoglobulin and T lymphocyte subgroup.
Results
1.Healing rate and total effective rate of observation group is 43.3%and 96.6%respectively,but control group's healing rate is 23.3%and it's total effective is 76.7%.this shows that observation group is more excellent than control group in curative effect(P＜0.05).
2.Warming moxibustion treatment can improve patien's symptoms obviously(P＜0.01),compared with control group,there is omly a wild improvement in cardinal symptoms(P＜0.01).
3.The contents of blood serum IgG、IgA、IgM in two groups pretherapy are nearly equivalency.After treatment,the contents of blood serum IgG、IgA showed an upward trend,While the content was obviously higher in observation group(P＜0.01),compared with control Group,the statistical comparison shows a significant difference(P＜0.05).After treatment,the contents of blood serum IgM showed an upward trend,compared with pretherapy,observation group has a significant difference(P＜0.05) merely.
4.After treatment,the contents of blood serum CD_3~+、CD_4~+、CD_4~+/CD_8
showed an upward trend,While the content was obviously higher in observation group(P＜0.01),compared with control Group,the statistical comparison shows a significant difference(P＜0.05).After treatment,the contents of blood serum CD_8~+ showed a downward trend,However,the observation group decreased significantly(P＜0.01 );compared with the control group,there was a significant difference(P＜0.05).
Conclusion
1.The clinical curative effect of chronic pelvic inflammatory by using warming moxibustion treatment is predominance,which is superior than control group obviously.
2.Warming moxibustion treatment can improve patien's symptoms obviously,which is superior than control group obviously.
3.warming moxibustion can accommodate the contents of peripheral blood Immunoglobulin and T lymphocyte subgroup on chronic pelvic inflammatory patients,improve organism immune function,it is a possible mechanism of treatment the disease by warming moxibustion.
引文
[1]曹泽毅.中华妇产科学[M].人民卫生出版社,1999:1212-1223.
[2]纪利侠,张晓娟.综合疗法治疗慢性盆腔炎78例疗效观察[J].临床和实验医学杂志,2008;7(1):119.
[3]余森泉,林祖才,贾广虹.16762例已婚育龄妇女生殖健康情况调查分析[J].广东医学,2004;25(7):840-841.
[4]罗小华.丹芍红藤汤配合中药保留灌肠治疗慢性盆腔炎104例临床观察[J].中医药导报,2008;14(2):38.
[5]Wo(?)niak PR,Stachowiak GP,Pieta-Doli(?)ska AK,et al.Anti-phlogistic and immunocompetent effects of acupuncture treatment in women suffering from chronic pelvic inflammatory diseases[J].Am J Chin Med.2003;31(2):315-320.
[6]陈利芳,蔡雪芬,王樟连.黄芪注射液穴位注射对慢性盆腔炎大鼠SIgA及细胞因子的影响[J].中华中医药学刊,2007;25(11):2321-2324.
[7]邢良美,李洁.运动对血清免疫球蛋白IgA、IgM、IgG的影响[J].吉林体育学院学报,2007;23(6):81.
[8]马宝璋.王树林.方风奇,等.炎克宁冲剂对大鼠慢性盆腔炎局部免疫功能的调节作用[J].中国中医药科技,2000;7(1):20-21.
[9]张文浩,黎明,胡自正.不孕症的免疫学因素[J].国外医学·计划生育分册,1990;(2):68.
[10]罗丽兰.生殖免疫学[M].武汉:湖北科学技术出版社,1998:11-12.
[11]郭世春.细胞因子与细菌感染[J].人民军医,1995;10:60.
[12]廖慧慧.慢性盆腔炎性不孕患者的免疫内分泌特点及其与中医证候的关系[J].广州中医药大学学报,2006;23(1):29.
[13]刘瑞芬,杨晓娜.盆腔炎颗粒对血瘀兼肾虚型慢性盆腔炎患者免疫学指标的影响[J].中国中西医结合杂志,2007;27(9):841.
[14]杨阳,王樟连.针灸治疗慢性盆腔炎的临床研究进展[J].针灸临床杂志,2006;22(12):68.
[15]马本绪.艾灸对机体免疫调节作用概述[J].江苏中医药,2008;40(1):86-87.
[16]苏应宽主编.新编实用妇科学[M].山东科学技术出版社,1999:133
[17]中华人民共和国卫生部.中药(新药)临床研究指导原则(第一辑)[M].1993:252.
[18]马宝璋主编.中医妇科学[M].上海科学技术出版社,1997年.
[19]陈百成,张晶主编.北京:人民卫生出版社(第1版)[M],2003:127.
[20]乐杰,谢幸,丰有吉.妇产科学(第6版)[M].人民卫生出版社,2004:268-276.
[21]王临虹,赵更力,陈丽君,等.已婚妇女生殖道感染患病情况调查[J].中华流行病学杂志,2000;21(6):464.
[22]邱冬梅,谭金凤.5985例已婚妇女妇科疾病普查分析[J].广东医学,2002:23(5):526-527.
[23]翟风利.12496名已婚纺织女工妇科疾病普查[J].中国工业医学杂志,2003:16(4):239-240.
[24]Catherine L.Haggerty,Riehard Schulz,Roberta B.Ness.Lower Quality of Life Among Women With Chronic Pelvic Pain After Pelvic Inflammatory Disease[J].obstetries&Gyneeology,2003,102(5):934.
[25]曹素月.盆腔炎发病因素的概念[J].实用妇科与产科杂志,1987;3(3):164.
[26]谭晓珊.腹腔镜检查对妇科慢性盆腔痛病因诊断的价值[J].遵义医学院学报,1996;19(3-4):204-207.
[27]谢希强,陈伟.138例慢性盆腔疼痛原因分析[J].河北医学,2001;7(4):339-340.
[28]胡丽娜,梁宪生,钱琛,等.不同年代女性不孕因素的比较研究[J]. 重庆医科大学学报,2000;25(3)277-279
[29]孙昌淑,郑法雷,康代,等.现代治疗学(第4版)[M].学苑出版社,1993:816.
[30]杜久伟,许克义,陈天义,等.女性不孕患者解脲支原体感染与外周血T细胞亚群水平检测[J].中国煤炭工业医学杂志,2006;9(4):345.
[31]何球藻,昊厚生.医学免疫学[M].上海:上海医科大学出版社,1997;第1版:77-79。
[32]刘瑞芬,杨晓娜.盆腔炎颗粒对血瘀兼肾虚型慢性盆腔炎患者免疫学指标的影响[J].中国中西医结合杂志,2007;27(9):841-843.
[33]孙晓玮,程体娟,罗慧英,等.竹叶椒片对大肠杆菌所致大鼠慢性盆腔炎的治疗作用[J].中国临床药理学与治疗学,2005;10(7)804-807.
[34]唐照亮,宋小鸽,章复清,等.艾灸抗炎免疫作用机制的实验研究[J].安徽中医学院学报,2003;22(2):31-35.
[35]朱文莲,刘仁权.艾灸大椎穴对免疫低下小鼠巨噬细胞吞噬功能的影响[J].北京中医药大学学报,2005;28(1):89-91.
[36]李晓军,李秀华,刘亚书.灸法配合耳穴贴压治疗放化疗所至不良反应32例[J].中国针灸,2001;21(9):523.
[37]袁民,傅莉萍,陈雪华,等.艾灸对荷瘤小鼠免疫功能的影响[J].针刺研究,2003;28(2):115-118.
[38]宋小鸽,唐照亮,侯正明,等.艾灸对吗啡戒断小鼠红细胞免疫功能的调节作用[J].中国中医基础医学杂志,2000;9(6):51-53.
[39]张英.不同灸疗时程对红细胞免疫功能影响的比较[J].中国针灸,2000:(10):613-614.
[40]曹毅,马泽云,郭平.艾灸阿是穴对多发性跖疣患者细胞免疫功能的调节作用[J].浙江中医学院学报,2004;9(4):64-65.
[41]朱苗花,徐兰凤,喻志冲,等.艾灸对宫颈癌放疗患者外周血T细胞 亚群的影响[J].南京中医药大学学报,2003;19(1):44-46.
[42]喻志冲,徐兰风,詹臻,等.艾灸对宫颈癌放疗患者免疫球蛋白的影响[J].上海针灸杂志,2002;21(6):15-16.
[43]陈秀华,李漾,甄宏鹏.针刺配合赵氏雷火灸治疗慢性盆腔炎临床研究.河南中医学院学报,2006;21(3):43-44.
[44]陈欣.灌肠加灸疗治疗慢性盆腔炎60例临床观察.光明中医,2009;24(4):695-696.
[45]刘英杰,李军,陈艳.阴道用温灸器治疗慢性盆腔炎、尿道炎30例临床观察[J].中国中医基础医学杂志,2006;12(4):297-298.
[1]乐杰.妇产科学[M].北京:人民卫生出版社,2000:295-296,302-303.
[2]叶临湘,朱桂宝,高元川,等.子宫肌瘤危险因素1:2病例对照Logistic 回归分析[J].中国公共卫生,1998;14(6):348-349.
[3]许雅,陈雅嘉,杨翌,等.子宫肌瘤发病危险因素的研究[J].中国公共卫生,2000;16(2):126-127.
[4]于子芳.针灸治疗慢性盆腔105例疗效分析[J].山西中医,2006;22(4):42-43.
[5]耿萍.针灸治疗盆腔炎208例临床观察[J].针灸临床杂志,2000;16(2):24.
[6]洪建云,陈磊.腹丛刺为主治疗慢性附件炎并发不孕症疗效观察[J].中国针灸,2004;24(9):593.
[7]江泓,徐金华.针刺治疗慢性盆腔炎100例疗效观察[J].江苏中医, 1998:19(7):36.
[8]蒋国庆.穴位注射治疗慢性盆腔炎120例疗效观察[J].针灸临床杂志,1999;15(10):32.
[9]刘晓辉.林可霉素穴位注射治疗慢性盆腔炎[J].中国针灸,2008;28(10):776.
[10]顾群.穴位注射治疗慢性盆腔炎的临床观察[J].针灸临床杂志,2004;20(1):40-41.
[11]黄纪云.中药穴位贴敷配含保留灌肠及物理治疗慢性盆腔炎153例[J].云南中医中药杂志,2002;23(5):25.
[12]沈克艰,吴梅珍.伏天铺灸治疗慢性盆腔炎的临床研究[J].上海针灸杂志,2005;24(5):19.
[13]金兰,蔡磊.药饼灸脐联合康妇消炎栓治疗慢性盆腔炎62例[J].实用中西医结合临床杂志,2004;4(5):51.
[14]汪小春,胡小荣,封俊光.腧穴热敏化艾灸治疗慢性盆腔炎30例[J].河南中医,2008;10:70.
[15]董联玲,王秀玲.温针治疗慢性盆腔炎疗效分析[J].山西中医,1998;14(5):39.
[16]岑克强.温针灸治疗慢性盆腔炎165例临床观察[J].吉林中医药,1999;1:35.
[17]陈建华.腹针配合艾灸治疗慢性盆腔炎疗效观察[J].上海针灸杂志,2008:27(4):26.
[18]骆金英,胡彩华,欧阳庆宜.针刺配合赵氏雷火灸治疗慢性盆腔炎40例[J].现代中西医结合杂志,2008;17(26):4110-4111.
[19]杜磊.针灸加TDP治疗慢性盐腔炎83例疗效观察[J].河北中医,2004:26(11):850.
[20]吕筠,王菊珍,等.调制中频电治疗盆腔炎疗效观察[J].中华理疗杂志,2000;23(5):312.
[21]王思新.针灸配合超短波治疗慢性盆腔炎58例[J].中国冶金工业医 学杂志,2007;24(5):572.
[22]朱彬.针灸结合中药灌肠治疗慢性盆腔炎113例[J].四川中医,2004;22(11):91.
[23]田明,任献青.针刺配合中药灌肠治疗慢性盆腔炎40例[J].湖北中医杂志,2004;26(1):50.
[24]邹建平.针刺配合中药灌肠治疗慢性盆腔炎60例[J].山东中医杂志,2007;26(4):249.
[25]王雁君.推拿治疗慢性盆腔炎[J].河南中医,1997;17(2):113
[26]张玉欣,王卉.刺络拔罐综合疗法治疗慢性盆腔炎100例[J].国医论坛,1997;12(4):38.
[27]钟建围,陈洪沛.耳穴贴压结合超短波治疗慢性盆腔炎临床观察[J].中国针灸,2004;24(10):691
[28]吕玉玲.耳压配合超短波等治疗慢性盆腔炎35例[J].山东医药,1999:39(22):60.
[29]袁玉欣.耳穴贴压配合中药离子导入治疗慢性盆腔炎76例[J].上海针灸杂志,2004;24(10):35.
[30]马向明.穴位埋线治慢性盆腔炎76例[J].江西中医药,1996;2:116.
[31]王竹珍,谢柏如,胡卫东等.水针刀药磁线四联治疗慢性盆腔炎临床研究[J].中国基层医药,2003;10(8):776-777.
[2]纪利侠,张晓娟.综合疗法治疗慢性盆腔炎78例疗效观察[J].临床和实验医学杂志,2008;7(1):119.
[3]余森泉,林祖才,贾广虹.16762例已婚育龄妇女生殖健康情况调查分析[J].广东医学,2004;25(7):840-841.
[4]罗小华.丹芍红藤汤配合中药保留灌肠治疗慢性盆腔炎104例临床观察[J].中医药导报,2008;14(2):38.
[5]Wo(?)niak PR,Stachowiak GP,Pieta-Doli(?)ska AK,et al.Anti-phlogistic and immunocompetent effects of acupuncture treatment in women suffering from chronic pelvic inflammatory diseases[J].Am J Chin Med.2003;31(2):315-320.
[6]陈利芳,蔡雪芬,王樟连.黄芪注射液穴位注射对慢性盆腔炎大鼠SIgA及细胞因子的影响[J].中华中医药学刊,2007;25(11):2321-2324.
[7]邢良美,李洁.运动对血清免疫球蛋白IgA、IgM、IgG的影响[J].吉林体育学院学报,2007;23(6):81.
[8]马宝璋.王树林.方风奇,等.炎克宁冲剂对大鼠慢性盆腔炎局部免疫功能的调节作用[J].中国中医药科技,2000;7(1):20-21.
[9]张文浩,黎明,胡自正.不孕症的免疫学因素[J].国外医学·计划生育分册,1990;(2):68.
[10]罗丽兰.生殖免疫学[M].武汉:湖北科学技术出版社,1998:11-12.
[11]郭世春.细胞因子与细菌感染[J].人民军医,1995;10:60.
[12]廖慧慧.慢性盆腔炎性不孕患者的免疫内分泌特点及其与中医证候的关系[J].广州中医药大学学报,2006;23(1):29.
[13]刘瑞芬,杨晓娜.盆腔炎颗粒对血瘀兼肾虚型慢性盆腔炎患者免疫学指标的影响[J].中国中西医结合杂志,2007;27(9):841.
[14]杨阳,王樟连.针灸治疗慢性盆腔炎的临床研究进展[J].针灸临床杂志,2006;22(12):68.
[15]马本绪.艾灸对机体免疫调节作用概述[J].江苏中医药,2008;40(1):86-87.
[16]苏应宽主编.新编实用妇科学[M].山东科学技术出版社,1999:133
[17]中华人民共和国卫生部.中药(新药)临床研究指导原则(第一辑)[M].1993:252.
[18]马宝璋主编.中医妇科学[M].上海科学技术出版社,1997年.
[19]陈百成,张晶主编.北京:人民卫生出版社(第1版)[M],2003:127.
[20]乐杰,谢幸,丰有吉.妇产科学(第6版)[M].人民卫生出版社,2004:268-276.
[21]王临虹,赵更力,陈丽君,等.已婚妇女生殖道感染患病情况调查[J].中华流行病学杂志,2000;21(6):464.
[22]邱冬梅,谭金凤.5985例已婚妇女妇科疾病普查分析[J].广东医学,2002:23(5):526-527.
[23]翟风利.12496名已婚纺织女工妇科疾病普查[J].中国工业医学杂志,2003:16(4):239-240.
[24]Catherine L.Haggerty,Riehard Schulz,Roberta B.Ness.Lower Quality of Life Among Women With Chronic Pelvic Pain After Pelvic Inflammatory Disease[J].obstetries&Gyneeology,2003,102(5):934.
[25]曹素月.盆腔炎发病因素的概念[J].实用妇科与产科杂志,1987;3(3):164.
[26]谭晓珊.腹腔镜检查对妇科慢性盆腔痛病因诊断的价值[J].遵义医学院学报,1996;19(3-4):204-207.
[27]谢希强,陈伟.138例慢性盆腔疼痛原因分析[J].河北医学,2001;7(4):339-340.
[28]胡丽娜,梁宪生,钱琛,等.不同年代女性不孕因素的比较研究[J]. 重庆医科大学学报,2000;25(3)277-279
[29]孙昌淑,郑法雷,康代,等.现代治疗学(第4版)[M].学苑出版社,1993:816.
[30]杜久伟,许克义,陈天义,等.女性不孕患者解脲支原体感染与外周血T细胞亚群水平检测[J].中国煤炭工业医学杂志,2006;9(4):345.
[31]何球藻,昊厚生.医学免疫学[M].上海:上海医科大学出版社,1997;第1版:77-79。
[32]刘瑞芬,杨晓娜.盆腔炎颗粒对血瘀兼肾虚型慢性盆腔炎患者免疫学指标的影响[J].中国中西医结合杂志,2007;27(9):841-843.
[33]孙晓玮,程体娟,罗慧英,等.竹叶椒片对大肠杆菌所致大鼠慢性盆腔炎的治疗作用[J].中国临床药理学与治疗学,2005;10(7)804-807.
[34]唐照亮,宋小鸽,章复清,等.艾灸抗炎免疫作用机制的实验研究[J].安徽中医学院学报,2003;22(2):31-35.
[35]朱文莲,刘仁权.艾灸大椎穴对免疫低下小鼠巨噬细胞吞噬功能的影响[J].北京中医药大学学报,2005;28(1):89-91.
[36]李晓军,李秀华,刘亚书.灸法配合耳穴贴压治疗放化疗所至不良反应32例[J].中国针灸,2001;21(9):523.
[37]袁民,傅莉萍,陈雪华,等.艾灸对荷瘤小鼠免疫功能的影响[J].针刺研究,2003;28(2):115-118.
[38]宋小鸽,唐照亮,侯正明,等.艾灸对吗啡戒断小鼠红细胞免疫功能的调节作用[J].中国中医基础医学杂志,2000;9(6):51-53.
[39]张英.不同灸疗时程对红细胞免疫功能影响的比较[J].中国针灸,2000:(10):613-614.
[40]曹毅,马泽云,郭平.艾灸阿是穴对多发性跖疣患者细胞免疫功能的调节作用[J].浙江中医学院学报,2004;9(4):64-65.
[41]朱苗花,徐兰凤,喻志冲,等.艾灸对宫颈癌放疗患者外周血T细胞 亚群的影响[J].南京中医药大学学报,2003;19(1):44-46.
[42]喻志冲,徐兰风,詹臻,等.艾灸对宫颈癌放疗患者免疫球蛋白的影响[J].上海针灸杂志,2002;21(6):15-16.
[43]陈秀华,李漾,甄宏鹏.针刺配合赵氏雷火灸治疗慢性盆腔炎临床研究.河南中医学院学报,2006;21(3):43-44.
[44]陈欣.灌肠加灸疗治疗慢性盆腔炎60例临床观察.光明中医,2009;24(4):695-696.
[45]刘英杰,李军,陈艳.阴道用温灸器治疗慢性盆腔炎、尿道炎30例临床观察[J].中国中医基础医学杂志,2006;12(4):297-298.
[1]乐杰.妇产科学[M].北京:人民卫生出版社,2000:295-296,302-303.
[2]叶临湘,朱桂宝,高元川,等.子宫肌瘤危险因素1:2病例对照Logistic 回归分析[J].中国公共卫生,1998;14(6):348-349.
[3]许雅,陈雅嘉,杨翌,等.子宫肌瘤发病危险因素的研究[J].中国公共卫生,2000;16(2):126-127.
[4]于子芳.针灸治疗慢性盆腔105例疗效分析[J].山西中医,2006;22(4):42-43.
[5]耿萍.针灸治疗盆腔炎208例临床观察[J].针灸临床杂志,2000;16(2):24.
[6]洪建云,陈磊.腹丛刺为主治疗慢性附件炎并发不孕症疗效观察[J].中国针灸,2004;24(9):593.
[7]江泓,徐金华.针刺治疗慢性盆腔炎100例疗效观察[J].江苏中医, 1998:19(7):36.
[8]蒋国庆.穴位注射治疗慢性盆腔炎120例疗效观察[J].针灸临床杂志,1999;15(10):32.
[9]刘晓辉.林可霉素穴位注射治疗慢性盆腔炎[J].中国针灸,2008;28(10):776.
[10]顾群.穴位注射治疗慢性盆腔炎的临床观察[J].针灸临床杂志,2004;20(1):40-41.
[11]黄纪云.中药穴位贴敷配含保留灌肠及物理治疗慢性盆腔炎153例[J].云南中医中药杂志,2002;23(5):25.
[12]沈克艰,吴梅珍.伏天铺灸治疗慢性盆腔炎的临床研究[J].上海针灸杂志,2005;24(5):19.
[13]金兰,蔡磊.药饼灸脐联合康妇消炎栓治疗慢性盆腔炎62例[J].实用中西医结合临床杂志,2004;4(5):51.
[14]汪小春,胡小荣,封俊光.腧穴热敏化艾灸治疗慢性盆腔炎30例[J].河南中医,2008;10:70.
[15]董联玲,王秀玲.温针治疗慢性盆腔炎疗效分析[J].山西中医,1998;14(5):39.
[16]岑克强.温针灸治疗慢性盆腔炎165例临床观察[J].吉林中医药,1999;1:35.
[17]陈建华.腹针配合艾灸治疗慢性盆腔炎疗效观察[J].上海针灸杂志,2008:27(4):26.
[18]骆金英,胡彩华,欧阳庆宜.针刺配合赵氏雷火灸治疗慢性盆腔炎40例[J].现代中西医结合杂志,2008;17(26):4110-4111.
[19]杜磊.针灸加TDP治疗慢性盐腔炎83例疗效观察[J].河北中医,2004:26(11):850.
[20]吕筠,王菊珍,等.调制中频电治疗盆腔炎疗效观察[J].中华理疗杂志,2000;23(5):312.
[21]王思新.针灸配合超短波治疗慢性盆腔炎58例[J].中国冶金工业医 学杂志,2007;24(5):572.
[22]朱彬.针灸结合中药灌肠治疗慢性盆腔炎113例[J].四川中医,2004;22(11):91.
[23]田明,任献青.针刺配合中药灌肠治疗慢性盆腔炎40例[J].湖北中医杂志,2004;26(1):50.
[24]邹建平.针刺配合中药灌肠治疗慢性盆腔炎60例[J].山东中医杂志,2007;26(4):249.
[25]王雁君.推拿治疗慢性盆腔炎[J].河南中医,1997;17(2):113
[26]张玉欣,王卉.刺络拔罐综合疗法治疗慢性盆腔炎100例[J].国医论坛,1997;12(4):38.
[27]钟建围,陈洪沛.耳穴贴压结合超短波治疗慢性盆腔炎临床观察[J].中国针灸,2004;24(10):691
[28]吕玉玲.耳压配合超短波等治疗慢性盆腔炎35例[J].山东医药,1999:39(22):60.
[29]袁玉欣.耳穴贴压配合中药离子导入治疗慢性盆腔炎76例[J].上海针灸杂志,2004;24(10):35.
[30]马向明.穴位埋线治慢性盆腔炎76例[J].江西中医药,1996;2:116.
[31]王竹珍,谢柏如,胡卫东等.水针刀药磁线四联治疗慢性盆腔炎临床研究[J].中国基层医药,2003;10(8):776-777.