温和灸治疗慢性浅表性胃炎的临床研究
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摘要
目的
慢性浅表性胃炎是临床常见病、多发病,发病率日益增高,对患者日常生活质量影响较大。本病西药治疗疗效欠佳,毒副作用大,针灸治疗独具特色,疗效肯定。本课题通过艾条温和灸治疗慢性浅表性胃炎患者,在临床观察的基础上,观测治疗前后胃粘膜血流量(GMBF)以及血清表皮生长因子(EGF)含量的变化,探讨艾条温和灸治疗慢性浅表性胃炎的作用机理,为温和灸治疗本病提供实验依据。
方法
60例患者均为湖北省丹江口市中医院中医科门诊或住院病人,均符合中华医学会消化病学分会在江西井冈山举行的慢性胃炎研讨会所拟定的慢性胃炎诊断标准。根据入院先后顺序,查随机数字表,将60例患者随机分为治疗组和对照组,每组各30例。治疗组采用温和灸治疗,取穴:胃俞、内关、中脘、足三里、梁丘、太冲。每穴艾灸5分钟。每日1次,每治疗7日休息1日。对照组口服法莫替丁,每次20mg,每日1次;铝碳酸镁片1g,1日3次,餐后1h嚼服;甲硝唑片,每次0.4g,每日2次;阿莫西林,每次0.5g,每日2次;后两药连服2周后停药。连续治疗1个月后,观察治疗前后两组综合疗效、主要症状及胃粘膜病变改善情况、GMBF及血清EGF含量的变化,并进行比较。
结果
1.治疗组治愈16例,占53.3%;显效8例,占26.7%;有效4例,占13.3%;无效2例,占6.7%;总有效率93.3%。对照组治愈9例,占30.0%;显效7例,占23.3%;有效6例,占20.0%,无效8例,占26.7%;总有效率73.3%。两组比较,经统计学分析,有显著性差异(P＜0.05),表明治疗组临床综合疗效明显优于对照组。
2.治疗组在治疗后患者胃脘痛、上腹胀、嗳气、泛酸及纳呆少食等主要症状均有明显改善,与治疗前相比,经统计学分析,有极显著性差异(P＜0.01)。对照组对上述症状虽有改善,但疗效不及治疗组明显。两组比较,经统计学处理,有显著性差异(P＜0.05),表明治疗组在改善主要症状方面明显优于对照组。
3.两组治疗后胃镜检查情况均有明显改善,与治疗前相比,经统计学分析,均有显著性差异(P＜0.05)。但治疗组治疗后,中度和重度例数明显少于对照组,两组比较,经统计学分析,有极显著性差异(P＜0.01)。表明治疗组在胃粘膜病变改善方面明显优于对照组。
4.治疗组治疗后,胃大弯、胃小弯、胃前壁、胃后壁GMBF明显增加,与治疗前比较,经统计学分析,有极显著性差异(P＜0.01)。对照组治疗后GMBF也有改善,与治疗前比较,经统计学分析,有显著性差异(P＜0.05)。两组比较,经统计学分析,有显著性差异(P＜0.05)。表明治疗组在改善慢性浅表性胃炎患者GMBF方面明显优于对照组。
5.治疗组治疗后,血清EGF含量显著降低,且接近于正常值,与治疗前比较,经统计学分析,有极显著性差异(P＜0.01)。对照组治疗后,血清EGF含量也有降低,与治疗前比较,经统计学分析,有显著性差异(P＜0.05)。两组比较,经统计学分析,有极显著性差异(P＜0.01)。表明治疗组对慢性浅表性胃炎患者血清EGF的调节明显优于对照组。
结论
1.温和灸治疗慢性浅表性胃炎疗效显著,明显优于对照组。
2.温和灸能显著增加GMBF,从而维持胃内的酸碱平衡,促进胃粘液的分泌和胃上皮细胞的更新,促进受损胃粘膜屏障修复。
3.温和灸能够显著降低慢性浅表性胃炎患者血清EGF含量,抑制胃粘膜的损伤,促进受损胃粘膜的修复。
Objective
Chronic superficial gastritis is a common ailment and frequently encountered disease in clinic.Its incidence rate has a increasing tendency and it has a bad contribution to people's quality of daily life.Western medicine treatment below the mark,acupuncture therapy has peculiarity and positive curative effect.In order to approach the mechanism of chronic superficial gastritis which was cured by warming moxibustion therapy,prior treatment and after treatment,we has a clinical observation and detect the gastric mucosal blood flow and blood epidermal growth factor(EGF),and try to build a scientific experiment foundation to support the treatment.
Method
60 case comes from Danjiangkou traditional Chinese medical hospital of Hubei province,they are consistent with chronic gastritis diagnostic criteria which is studyed out by Chinese Medical Associationat aeminar of chronic gastritis in jinggangshan,jiangxi province.According to the order in which paitients admitted to hospital,and check the random number table,All the cases are randomly divided into two groups,each group 30 cases.The observation group adopts warming moxibustion therapy,we select zhongwan, weisu,neiguan,liangqiu,zusanli,taichong to to treat the patient by warming moxibustion therapy,zusanli is treated for 10 minutes,the rest acupoints are treated for 5 minutes,a vic per day,one day resting after seven days treatment, and going on the next circulation.The control group adopts western medicine: such as Famotidine,20mg ter in die;Talcid,lg ter in die,3 times a day,a hour after the dinner;Metronidazole,0.4g bid and Amoxicillin,0.5g bid after taking two weeks,stop taking.To evaluate therapeutic effect after one month reament. After the treatments of 1 months we will observe general effects,the main symptoms and signs of improvement,improvement in gastric mucosal blood flow and serum epidermal growth factor in the changes before and after treatment.
Results
1.Observation group:healing rate is 53.3%,excellence rate is 26.7%, utility rate is 13.3%,inefficacy rate is 6.7%,the total effective rate was 93.3%. Control group:healing rate is 30.0%,excellence rate is 23.3%,utility rate is 20.0%,inefficacy rate is 26.7%,the total effective rate was 73.3%.Under statistical treatment,there is a significant difference(P＜0.05),efficacy of the observation group is superior to the control group.
2.Warming moxibustion therapy can improve patien's cardinal symptoms obviously such as gastric abscess,epigastric distention,belching, bepanthen,anorexia(P＜0.01).Compared with control group,there is omly a wild improvement in cardinal symptoms.
3.Two groups can both improve gastroscopy obviously(P＜0.01),but post-treatment,observation group has less quantity in Midrange and badrange gastroscopy than control group(p＜0.05).
4.After warming moxibustion therapy,mucosal blood flow of curvatura gastrica major,curvatura gastrica minor,paries anterior gastricus,paries posterior gastricus increase greatly(P＜0.01);post-treatment,control group has a mild improvement in mucosal blood flow(p＜0.05),the results shows that observation group has a more excellent improvement in mucosal blood flow than control group and acupuncture treatment can facilitate recovery of gastric mucosa.
5.After warming moxibustion therapy,the content of blood serum EGF degrade obviously(p＜0.01),the content of blood serum EGF of control group after treatment also degrade greatly(p＜0.05),but result shows that observation group is more excellent in adjusting content of blood serum EGF than control group.
Conclusion
1.The clinical curative effect of chronic superficial gastritis by using warming moxibustion therapy is predominance,which is superior than control group obviously.
2.Warming moxibustion therapy can increase gastric mucosal blood flow significantly,so as to maintain the acid-base balance of intragastrically,hasten the externalization of gastric mucosa and gastric mucosa of epithelial cells, and promote the reparation of damaged gastric mucosa barrier.
3.Warming moxibustion therapy can change the contents of blood serum EGF obviously in chronic superficial gastritis's patients,and it is gradually recovering to normal value level.The result shows that warming moxibustion therapy suppress the damage of gastric mucosa,and enhanced the anti-oxidation ability of organism,so it can promote the reparation of damaged gastric mucosa promptly.
慢性浅表性胃炎是临床常见病、多发病,发病率日益增高,对患者日常生活质量影响较大。本病西药治疗疗效欠佳,毒副作用大,针灸治疗独具特色,疗效肯定。本课题通过艾条温和灸治疗慢性浅表性胃炎患者,在临床观察的基础上,观测治疗前后胃粘膜血流量(GMBF)以及血清表皮生长因子(EGF)含量的变化,探讨艾条温和灸治疗慢性浅表性胃炎的作用机理,为温和灸治疗本病提供实验依据。
方法
60例患者均为湖北省丹江口市中医院中医科门诊或住院病人,均符合中华医学会消化病学分会在江西井冈山举行的慢性胃炎研讨会所拟定的慢性胃炎诊断标准。根据入院先后顺序,查随机数字表,将60例患者随机分为治疗组和对照组,每组各30例。治疗组采用温和灸治疗,取穴:胃俞、内关、中脘、足三里、梁丘、太冲。每穴艾灸5分钟。每日1次,每治疗7日休息1日。对照组口服法莫替丁,每次20mg,每日1次;铝碳酸镁片1g,1日3次,餐后1h嚼服;甲硝唑片,每次0.4g,每日2次;阿莫西林,每次0.5g,每日2次;后两药连服2周后停药。连续治疗1个月后,观察治疗前后两组综合疗效、主要症状及胃粘膜病变改善情况、GMBF及血清EGF含量的变化,并进行比较。
结果
1.治疗组治愈16例,占53.3%;显效8例,占26.7%;有效4例,占13.3%;无效2例,占6.7%;总有效率93.3%。对照组治愈9例,占30.0%;显效7例,占23.3%;有效6例,占20.0%,无效8例,占26.7%;总有效率73.3%。两组比较,经统计学分析,有显著性差异(P＜0.05),表明治疗组临床综合疗效明显优于对照组。
2.治疗组在治疗后患者胃脘痛、上腹胀、嗳气、泛酸及纳呆少食等主要症状均有明显改善,与治疗前相比,经统计学分析,有极显著性差异(P＜0.01)。对照组对上述症状虽有改善,但疗效不及治疗组明显。两组比较,经统计学处理,有显著性差异(P＜0.05),表明治疗组在改善主要症状方面明显优于对照组。
3.两组治疗后胃镜检查情况均有明显改善,与治疗前相比,经统计学分析,均有显著性差异(P＜0.05)。但治疗组治疗后,中度和重度例数明显少于对照组,两组比较,经统计学分析,有极显著性差异(P＜0.01)。表明治疗组在胃粘膜病变改善方面明显优于对照组。
4.治疗组治疗后,胃大弯、胃小弯、胃前壁、胃后壁GMBF明显增加,与治疗前比较,经统计学分析,有极显著性差异(P＜0.01)。对照组治疗后GMBF也有改善,与治疗前比较,经统计学分析,有显著性差异(P＜0.05)。两组比较,经统计学分析,有显著性差异(P＜0.05)。表明治疗组在改善慢性浅表性胃炎患者GMBF方面明显优于对照组。
5.治疗组治疗后,血清EGF含量显著降低,且接近于正常值,与治疗前比较,经统计学分析,有极显著性差异(P＜0.01)。对照组治疗后,血清EGF含量也有降低,与治疗前比较,经统计学分析,有显著性差异(P＜0.05)。两组比较,经统计学分析,有极显著性差异(P＜0.01)。表明治疗组对慢性浅表性胃炎患者血清EGF的调节明显优于对照组。
结论
1.温和灸治疗慢性浅表性胃炎疗效显著,明显优于对照组。
2.温和灸能显著增加GMBF,从而维持胃内的酸碱平衡,促进胃粘液的分泌和胃上皮细胞的更新,促进受损胃粘膜屏障修复。
3.温和灸能够显著降低慢性浅表性胃炎患者血清EGF含量,抑制胃粘膜的损伤,促进受损胃粘膜的修复。
Objective
Chronic superficial gastritis is a common ailment and frequently encountered disease in clinic.Its incidence rate has a increasing tendency and it has a bad contribution to people's quality of daily life.Western medicine treatment below the mark,acupuncture therapy has peculiarity and positive curative effect.In order to approach the mechanism of chronic superficial gastritis which was cured by warming moxibustion therapy,prior treatment and after treatment,we has a clinical observation and detect the gastric mucosal blood flow and blood epidermal growth factor(EGF),and try to build a scientific experiment foundation to support the treatment.
Method
60 case comes from Danjiangkou traditional Chinese medical hospital of Hubei province,they are consistent with chronic gastritis diagnostic criteria which is studyed out by Chinese Medical Associationat aeminar of chronic gastritis in jinggangshan,jiangxi province.According to the order in which paitients admitted to hospital,and check the random number table,All the cases are randomly divided into two groups,each group 30 cases.The observation group adopts warming moxibustion therapy,we select zhongwan, weisu,neiguan,liangqiu,zusanli,taichong to to treat the patient by warming moxibustion therapy,zusanli is treated for 10 minutes,the rest acupoints are treated for 5 minutes,a vic per day,one day resting after seven days treatment, and going on the next circulation.The control group adopts western medicine: such as Famotidine,20mg ter in die;Talcid,lg ter in die,3 times a day,a hour after the dinner;Metronidazole,0.4g bid and Amoxicillin,0.5g bid after taking two weeks,stop taking.To evaluate therapeutic effect after one month reament. After the treatments of 1 months we will observe general effects,the main symptoms and signs of improvement,improvement in gastric mucosal blood flow and serum epidermal growth factor in the changes before and after treatment.
Results
1.Observation group:healing rate is 53.3%,excellence rate is 26.7%, utility rate is 13.3%,inefficacy rate is 6.7%,the total effective rate was 93.3%. Control group:healing rate is 30.0%,excellence rate is 23.3%,utility rate is 20.0%,inefficacy rate is 26.7%,the total effective rate was 73.3%.Under statistical treatment,there is a significant difference(P＜0.05),efficacy of the observation group is superior to the control group.
2.Warming moxibustion therapy can improve patien's cardinal symptoms obviously such as gastric abscess,epigastric distention,belching, bepanthen,anorexia(P＜0.01).Compared with control group,there is omly a wild improvement in cardinal symptoms.
3.Two groups can both improve gastroscopy obviously(P＜0.01),but post-treatment,observation group has less quantity in Midrange and badrange gastroscopy than control group(p＜0.05).
4.After warming moxibustion therapy,mucosal blood flow of curvatura gastrica major,curvatura gastrica minor,paries anterior gastricus,paries posterior gastricus increase greatly(P＜0.01);post-treatment,control group has a mild improvement in mucosal blood flow(p＜0.05),the results shows that observation group has a more excellent improvement in mucosal blood flow than control group and acupuncture treatment can facilitate recovery of gastric mucosa.
5.After warming moxibustion therapy,the content of blood serum EGF degrade obviously(p＜0.01),the content of blood serum EGF of control group after treatment also degrade greatly(p＜0.05),but result shows that observation group is more excellent in adjusting content of blood serum EGF than control group.
Conclusion
1.The clinical curative effect of chronic superficial gastritis by using warming moxibustion therapy is predominance,which is superior than control group obviously.
2.Warming moxibustion therapy can increase gastric mucosal blood flow significantly,so as to maintain the acid-base balance of intragastrically,hasten the externalization of gastric mucosa and gastric mucosa of epithelial cells, and promote the reparation of damaged gastric mucosa barrier.
3.Warming moxibustion therapy can change the contents of blood serum EGF obviously in chronic superficial gastritis's patients,and it is gradually recovering to normal value level.The result shows that warming moxibustion therapy suppress the damage of gastric mucosa,and enhanced the anti-oxidation ability of organism,so it can promote the reparation of damaged gastric mucosa promptly.
引文
[1]侯进军,吴晓青.健胃愈疡片及相关性模拟治疗慢性浅表性胃炎的对比性研究[J].中华实用中西医杂志,2004;17(24):4733.
[2]赵学魁.麦门冬汤加减治疗慢性浅表性胃炎的体会[J].上海中医药杂志,2004;38(4):19.
[3]张燕,高秀芬,于晓宏.虚寒及气滞型慢性胃炎胃粘膜血流量的观察[J].中华实用中西医杂志,1998;11(1):16.
[4]Barnard,J.A.,Beauchamp,R.D.,Russell,W.E.,DuBois,R.N.,and offey,R.J.Epidermal growth factorrelated peptides and their relevance to gastrointestinal pathophysiology[J].Gastroenterology.1995;108:564-580.
[5]Ostrowski J,Wojciechowski K,Konturek SJ,etal,Inhitory effect of EGF on secretory response of rat clorital cells isassociated with an in2 duction of ODC[J].AM J physiol.1993;264(6):1428.
[6]中华医学会消化病学分会.全国慢性胃炎研讨会共识意见[J].中华消化杂志,2000;20(3):199.
[7]中华人民共和国卫生部.中药新药临床研究指导原则[M].第二辑,北京:中国医药科技出版社,1995;114-122.
[8]中国中西医结合学会消化系统疾病专业委员会.慢性胃炎的中西医结合诊治方案[J].现代消化及介入诊疗,2005;10(3):181-184.
[9]干兆芬.胃粘膜血流的生理和病理生理[J].国外医学,1985;3:1295.
[10]江庆淇,许文波,杨丹红.艾灸对大鼠胃粘膜血流量的影响及与胃肠激素的关系[J].现代康复;2000;4(12):40.
[11]Konturek J W,Brzozowski T,Konturek SJ.Epidermal growth factor in protection,repair,and healing of gastroduodenal mucosa[J].Clin Gastroenterol.1991;13:S88-97.
[12]Konturek JW,Brzozowski T,Konturek S J,Bogdal J,Oleksy J.Distribution and release of epidermal growth factor in man[J].Gut.1989; 30(1):194-200.
[13]Barnard,J.A.,Beauchamp,R.D.,Russell,W.E.,DuBois,R.N.,and offey,R.J.Epidermal growth factorrelated peptides and their relevance to gastrointestinal pathophysiology[J].Gastroenterology.1995;108:564-580.
[14]Qlayford RJ,Bouiron R,Ghatei MA,etal.Comparison of the effets of transforming growth actor and epidermal growth actor on gastrointestinal proliferation and hormone release[J].Digestion 1996;57:362.
[15]Hui WM,Chen BU,Kung AWC,etal.Effact of epidermalgrowth factor on gastric blood flow in rats[J].Gastroenterology,1993;104(6):1605.
[16]Ostrowski J,Wojciechowski K,Konturek SJ,etal.Inhitoryeffect of EGF on secretory response of rat clorital cells isassociated with an in 2 duction of ODC[J].AM J physiol,1993;264(6):1428.
[17]Ishi Kawa T,Tarnawski A,Sarfeh IJ,etal.Epidermal growthfactor protects gastric mucosa against ischemia reperfuaioninjury[J].J chin Gastroenteral.1993;17(suppl 1):104.
[18]Daig R,Rogler G,Aschenbrenner E,etal.Human intestinal epithelial cells secretinterleukin-1 receptor antagonist and interleukin-8 but not interleukin- 1 orinterleukin-6[J].Gut,2000;46(3):350.
[19]唐照亮.艾灸抗炎免疫作用机制的实验研究[J].安徽中医学院学报,2003:22(2):31-35.
[20]袁娟.艾灸调节免疫作用的研究进展[J].安徽中医学院学报,2007;26(2)60-61.
[21]成华,张天成,刘炬,等.隔盐姜灸治疗急性胃肠炎126例[J].中国针灸,2002;22(11):744.
[22]张毅明,韩华钦.隔药饼灸治疗反流性胃炎32例[J].现代中西医结合杂志,2009;18(1):30.
[23]许佳年,孟丹.灸药结合治疗慢性萎缩性胃炎30例[J].中国民间疗 法,2002;10(2):15-16.
[24]易受乡,林亚平,吴芳,等.神阙穴隔药饼灸、单纯灸及灯光灸对胃黏膜损伤保护作用的对比研究[J].中国中医药信息杂志,2005;12(10):31-32.
[1]潘时忠.针刺神阙穴治疗慢性浅表性胃炎[J].中国针灸,1994;(S): 29.
[2]刘昌海,宋效芝.针刺华佗夹脊穴治疗胃脘痛80例临床观察[J].1995;11(6):39.
[3]段昭侠.针刺治疗慢性胃炎70例[J].陕西中医,2004;25(9):837.
[4]辛银虎,陈小玲.温针治疗脾胃虚寒型慢性浅表性胃炎52例[J].陕西中医,2005;26(9):959.
[5]秦云.温针隔姜灸治疗脾胃虚寒型胃肮疼116例临床观察[J].长春中医学院学报,2004;20(3):24.
[6]王秀芬,徐金秀.艾灸结合经络导平治疗慢性浅表性胃炎.河北中西结合杂志,1998;7(5):729.
[7]刘景欣,于雷,王新奇.针刺配合隔饼灸治疗慢性胃炎20例[J].上海针灸杂志,2003;22(4):25.
[8]张谦,杨文斌.针灸并用治疗慢性胃炎65例临床观察[J].中国临床医药研究杂志,2004;11(9):12570.
[9]袁静,高希言.针灸治疗慢性萎缩性胃炎的临床研究[J].浙江中医杂志,2006;41(5):263-264.
[10]胡晓贤,毕宇峰,方安明.针灸配合火罐疗法治疗浅表性、萎缩性胃炎86例临床疗效观察[J].针灸临床杂志,1994;10(1):15-16.
[11]王洪伟,高青,王孜优.拔水罐加针刺治疗HP阳性慢性浅表性胃炎96例临床观察[J].中国针灸,1999;5:271-272.
[12]张建功,王兴凯.附子理中丸配针灸治疗慢性胃炎75例临床观察[J].国医论坛,2005,20(3):9.
[13]张弛,周章玲.针灸配合中药治疗慢性胃炎110例[J].中西医结合学报,2003;1(2):141,159.
[14]黄辉,李可可,周先荣.针灸配合西药治疗幽门螺杆菌感染性慢性萎缩性胃炎58例[J].中华实用中西医杂志,2005;18(6):821-822.
[15]吕传增,周素兰.电针穴位注射疗法治疗慢性胃炎58例[J].实用中医药杂志,1998;14(4):9.
[16]蔡丽娜,曾伟.穴位埋线治疗胃痛17例[J].中国民间疗法,2001;9(5):12.
[17]雷德林,何吉春,黄彩凤.穴位埋药线治疗慢性胃病1660例疗效观察[J].现代中西医结合杂志,2005;14(4):436.
[18]姜守信.穴位埋线治疗慢性胃炎200例[J].针灸临床杂志,2003;19(4):47.
[19]李红,邹军,张家维.穴位埋线治疗慢性胃炎的临床研究[J].中国康复医学杂志,2005;20(2):133-134.
[20]姚秋玲,刘克银.穴位埋线治疗慢性萎缩性胃炎38例[J].针灸临床杂志,2002;18(8):51.
[21]罗先乐,汪红霞.穴位注射治疗胃痛6例[J].中国民间疗法,1999;(1):9.
[22]宋建宁,陈庆龄.穴位注射、针刺治疗慢性浅表性胃炎70例疗效比较[J].FJMedica,2002;24(5):161.
[23]孙媛媛.火针治疗慢性胃炎疗效观察[J].上海针灸杂志,2003;22(12:)28.
[24]李立.梅花针叩刺治疗慢性胃炎48例[J].针灸临床杂志,2003;23(4):202.
[25]王令习,王晶.针刀治疗浅表性胃炎的临床随机对照观察[J].世界科学技术-中医药现代化科技论坛,2006;8(4):124-127.
[26]罗凛.推拿治疗慢性浅表性胃炎42例疗效观察[J].河北中医,2004;26(8):611-622.
[27]曹克刚,李德志.按摩治疗慢性浅表性胃炎30例[J].中华综合医学杂志,2005;6(6):535-536.
[28]赵彩娇,谢感共,翁泰来,等.灵龟八法治疗慢性浅表性胃炎临床观察[J].针灸临床杂志,2002;18(11):6-8.
[29]高希言,吕金秀.,刘望乐,等.针灸对胃粘膜屏障功能影响的实验研究[J].中国中医药科技,2001;8(5):277-278.
[30]王月芳,刘元亮,许冠荪,等.L-Arg-NO通路在针灸对胃粘膜损伤保护中的作用[J].中国中医药科技,1999;6(5):281-283.
[31]陈德成,吴旭,朱云华,等.穴位注射对慢性萎缩性胃炎患者PCNA 和Ag-NOR的影响[J].中国针灸,2000;20(12):738-740.
[32]程延安.针灸对慢性萎缩性胃炎大鼠胃液总酸度及胃蛋白酶活性影响的研究[J].中国中医药科技,2002;9(6):323-324.
[33]张文娟,高希言,郭书敏.针灸对胃液总酸度及胃蛋白酶活性影响的研究[J].中国自然医学杂志,2001;3(4):202-204.
[34]孙玉霞,王瑞莉,贾成文,等.针刺对慢性萎缩性胃炎大鼠血清胃泌素和血浆胃动素水平的影响[J].陕西中医,2006;27(10):1301-1302.
[35]韩儒启.针灸对胃炎治疗作用及机理初探[J].陕西中医,2001;22(10):320-321.
[36]李红,唐纯志,李素荷.穴位埋线对慢性胃炎患者环核苷酸及胃肠激素的影响[J].中国针灸,2005,25(5):301-303.
[37]李红,李素荷,唐纯志,等.穴位埋线对慢性胃炎患者胃电图及胃肠激素的影响[J].广州中医药大学学报,2005;22(2):123-126.
[38]杨文英,周文新,孙克兴.疾病状态下腧穴超微弱发光的研究[J].上海针灸杂志,1998;17(6):2-3.
[2]赵学魁.麦门冬汤加减治疗慢性浅表性胃炎的体会[J].上海中医药杂志,2004;38(4):19.
[3]张燕,高秀芬,于晓宏.虚寒及气滞型慢性胃炎胃粘膜血流量的观察[J].中华实用中西医杂志,1998;11(1):16.
[4]Barnard,J.A.,Beauchamp,R.D.,Russell,W.E.,DuBois,R.N.,and offey,R.J.Epidermal growth factorrelated peptides and their relevance to gastrointestinal pathophysiology[J].Gastroenterology.1995;108:564-580.
[5]Ostrowski J,Wojciechowski K,Konturek SJ,etal,Inhitory effect of EGF on secretory response of rat clorital cells isassociated with an in2 duction of ODC[J].AM J physiol.1993;264(6):1428.
[6]中华医学会消化病学分会.全国慢性胃炎研讨会共识意见[J].中华消化杂志,2000;20(3):199.
[7]中华人民共和国卫生部.中药新药临床研究指导原则[M].第二辑,北京:中国医药科技出版社,1995;114-122.
[8]中国中西医结合学会消化系统疾病专业委员会.慢性胃炎的中西医结合诊治方案[J].现代消化及介入诊疗,2005;10(3):181-184.
[9]干兆芬.胃粘膜血流的生理和病理生理[J].国外医学,1985;3:1295.
[10]江庆淇,许文波,杨丹红.艾灸对大鼠胃粘膜血流量的影响及与胃肠激素的关系[J].现代康复;2000;4(12):40.
[11]Konturek J W,Brzozowski T,Konturek SJ.Epidermal growth factor in protection,repair,and healing of gastroduodenal mucosa[J].Clin Gastroenterol.1991;13:S88-97.
[12]Konturek JW,Brzozowski T,Konturek S J,Bogdal J,Oleksy J.Distribution and release of epidermal growth factor in man[J].Gut.1989; 30(1):194-200.
[13]Barnard,J.A.,Beauchamp,R.D.,Russell,W.E.,DuBois,R.N.,and offey,R.J.Epidermal growth factorrelated peptides and their relevance to gastrointestinal pathophysiology[J].Gastroenterology.1995;108:564-580.
[14]Qlayford RJ,Bouiron R,Ghatei MA,etal.Comparison of the effets of transforming growth actor and epidermal growth actor on gastrointestinal proliferation and hormone release[J].Digestion 1996;57:362.
[15]Hui WM,Chen BU,Kung AWC,etal.Effact of epidermalgrowth factor on gastric blood flow in rats[J].Gastroenterology,1993;104(6):1605.
[16]Ostrowski J,Wojciechowski K,Konturek SJ,etal.Inhitoryeffect of EGF on secretory response of rat clorital cells isassociated with an in 2 duction of ODC[J].AM J physiol,1993;264(6):1428.
[17]Ishi Kawa T,Tarnawski A,Sarfeh IJ,etal.Epidermal growthfactor protects gastric mucosa against ischemia reperfuaioninjury[J].J chin Gastroenteral.1993;17(suppl 1):104.
[18]Daig R,Rogler G,Aschenbrenner E,etal.Human intestinal epithelial cells secretinterleukin-1 receptor antagonist and interleukin-8 but not interleukin- 1 orinterleukin-6[J].Gut,2000;46(3):350.
[19]唐照亮.艾灸抗炎免疫作用机制的实验研究[J].安徽中医学院学报,2003:22(2):31-35.
[20]袁娟.艾灸调节免疫作用的研究进展[J].安徽中医学院学报,2007;26(2)60-61.
[21]成华,张天成,刘炬,等.隔盐姜灸治疗急性胃肠炎126例[J].中国针灸,2002;22(11):744.
[22]张毅明,韩华钦.隔药饼灸治疗反流性胃炎32例[J].现代中西医结合杂志,2009;18(1):30.
[23]许佳年,孟丹.灸药结合治疗慢性萎缩性胃炎30例[J].中国民间疗 法,2002;10(2):15-16.
[24]易受乡,林亚平,吴芳,等.神阙穴隔药饼灸、单纯灸及灯光灸对胃黏膜损伤保护作用的对比研究[J].中国中医药信息杂志,2005;12(10):31-32.
[1]潘时忠.针刺神阙穴治疗慢性浅表性胃炎[J].中国针灸,1994;(S): 29.
[2]刘昌海,宋效芝.针刺华佗夹脊穴治疗胃脘痛80例临床观察[J].1995;11(6):39.
[3]段昭侠.针刺治疗慢性胃炎70例[J].陕西中医,2004;25(9):837.
[4]辛银虎,陈小玲.温针治疗脾胃虚寒型慢性浅表性胃炎52例[J].陕西中医,2005;26(9):959.
[5]秦云.温针隔姜灸治疗脾胃虚寒型胃肮疼116例临床观察[J].长春中医学院学报,2004;20(3):24.
[6]王秀芬,徐金秀.艾灸结合经络导平治疗慢性浅表性胃炎.河北中西结合杂志,1998;7(5):729.
[7]刘景欣,于雷,王新奇.针刺配合隔饼灸治疗慢性胃炎20例[J].上海针灸杂志,2003;22(4):25.
[8]张谦,杨文斌.针灸并用治疗慢性胃炎65例临床观察[J].中国临床医药研究杂志,2004;11(9):12570.
[9]袁静,高希言.针灸治疗慢性萎缩性胃炎的临床研究[J].浙江中医杂志,2006;41(5):263-264.
[10]胡晓贤,毕宇峰,方安明.针灸配合火罐疗法治疗浅表性、萎缩性胃炎86例临床疗效观察[J].针灸临床杂志,1994;10(1):15-16.
[11]王洪伟,高青,王孜优.拔水罐加针刺治疗HP阳性慢性浅表性胃炎96例临床观察[J].中国针灸,1999;5:271-272.
[12]张建功,王兴凯.附子理中丸配针灸治疗慢性胃炎75例临床观察[J].国医论坛,2005,20(3):9.
[13]张弛,周章玲.针灸配合中药治疗慢性胃炎110例[J].中西医结合学报,2003;1(2):141,159.
[14]黄辉,李可可,周先荣.针灸配合西药治疗幽门螺杆菌感染性慢性萎缩性胃炎58例[J].中华实用中西医杂志,2005;18(6):821-822.
[15]吕传增,周素兰.电针穴位注射疗法治疗慢性胃炎58例[J].实用中医药杂志,1998;14(4):9.
[16]蔡丽娜,曾伟.穴位埋线治疗胃痛17例[J].中国民间疗法,2001;9(5):12.
[17]雷德林,何吉春,黄彩凤.穴位埋药线治疗慢性胃病1660例疗效观察[J].现代中西医结合杂志,2005;14(4):436.
[18]姜守信.穴位埋线治疗慢性胃炎200例[J].针灸临床杂志,2003;19(4):47.
[19]李红,邹军,张家维.穴位埋线治疗慢性胃炎的临床研究[J].中国康复医学杂志,2005;20(2):133-134.
[20]姚秋玲,刘克银.穴位埋线治疗慢性萎缩性胃炎38例[J].针灸临床杂志,2002;18(8):51.
[21]罗先乐,汪红霞.穴位注射治疗胃痛6例[J].中国民间疗法,1999;(1):9.
[22]宋建宁,陈庆龄.穴位注射、针刺治疗慢性浅表性胃炎70例疗效比较[J].FJMedica,2002;24(5):161.
[23]孙媛媛.火针治疗慢性胃炎疗效观察[J].上海针灸杂志,2003;22(12:)28.
[24]李立.梅花针叩刺治疗慢性胃炎48例[J].针灸临床杂志,2003;23(4):202.
[25]王令习,王晶.针刀治疗浅表性胃炎的临床随机对照观察[J].世界科学技术-中医药现代化科技论坛,2006;8(4):124-127.
[26]罗凛.推拿治疗慢性浅表性胃炎42例疗效观察[J].河北中医,2004;26(8):611-622.
[27]曹克刚,李德志.按摩治疗慢性浅表性胃炎30例[J].中华综合医学杂志,2005;6(6):535-536.
[28]赵彩娇,谢感共,翁泰来,等.灵龟八法治疗慢性浅表性胃炎临床观察[J].针灸临床杂志,2002;18(11):6-8.
[29]高希言,吕金秀.,刘望乐,等.针灸对胃粘膜屏障功能影响的实验研究[J].中国中医药科技,2001;8(5):277-278.
[30]王月芳,刘元亮,许冠荪,等.L-Arg-NO通路在针灸对胃粘膜损伤保护中的作用[J].中国中医药科技,1999;6(5):281-283.
[31]陈德成,吴旭,朱云华,等.穴位注射对慢性萎缩性胃炎患者PCNA 和Ag-NOR的影响[J].中国针灸,2000;20(12):738-740.
[32]程延安.针灸对慢性萎缩性胃炎大鼠胃液总酸度及胃蛋白酶活性影响的研究[J].中国中医药科技,2002;9(6):323-324.
[33]张文娟,高希言,郭书敏.针灸对胃液总酸度及胃蛋白酶活性影响的研究[J].中国自然医学杂志,2001;3(4):202-204.
[34]孙玉霞,王瑞莉,贾成文,等.针刺对慢性萎缩性胃炎大鼠血清胃泌素和血浆胃动素水平的影响[J].陕西中医,2006;27(10):1301-1302.
[35]韩儒启.针灸对胃炎治疗作用及机理初探[J].陕西中医,2001;22(10):320-321.
[36]李红,唐纯志,李素荷.穴位埋线对慢性胃炎患者环核苷酸及胃肠激素的影响[J].中国针灸,2005,25(5):301-303.
[37]李红,李素荷,唐纯志,等.穴位埋线对慢性胃炎患者胃电图及胃肠激素的影响[J].广州中医药大学学报,2005;22(2):123-126.
[38]杨文英,周文新,孙克兴.疾病状态下腧穴超微弱发光的研究[J].上海针灸杂志,1998;17(6):2-3.