组织因子在肾癌中的表达及其临床意义
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摘要
目的:检测肾癌组织、癌旁正常肾组织中组织因子蛋白的表达,以了解组织因子蛋白与肾癌发生发展的关系及其在肾癌治疗方面的临床应用价值。
方法:运用免疫组织化学MaxVision?法分别检测30例肾癌组织及15例作为对照的癌旁正常肾组织中组织因子蛋白的表达情况,并相互比较结果进行分析。
结果:组织因子在肾癌组织中的表达率90%(30例肾癌组织中有27例表达阳性)显著高于在癌旁正常组织中的表达率13.3%(15例癌旁正常肾组织中有2例表达阳性)。组织因子在肾癌及癌旁正常肾组织中的表达有显著性差异,具有统计学意义。
结论:组织因子与肾癌的发生、发展可能具有密切关系。根据组织因子蛋白在肾癌及癌旁正常肾组织中表达的差异,临床上可能能够利用组织因子蛋白对肾癌进行诊断和肿瘤靶向治疗。它可能在肾癌的治疗方面具有一定的临床价值。
Objective To inspect the expression of tissue factor (TF) in renal cell carcinoma and in adjacent normal renal tissues ,and to know the relationship of tissue factor expression with carcinogenesis and progression in renal cell carcinoma and its clinical applying value in renal cell carcinoma treatment.
Methods Detected the expression of tissue factor in 30 cases of renal cell carcinoma and 15 cases of the adjacent normal kidney tissue by MaxVision? immunhistochemistry method,then analyzed the results by comparing its.
Results The expression rate of tissue factor in renal cell carcinoma is 90%(27 cases are positive in 30 cases of renal cell carcinoma )was significantly higher than in the adjacent normal kidney tissue of 13.3%(2 cases are positive in 15 cases of the adjacent normal kidney tissue). The expression of tissue factor in renal cell carcinoma and the adjacent normal kidney tissue was sinnificantly different and the difference have statistics significance.
Conclusion Maybe there is a close relationship between tissue factor and renal cell carcinoma,According to the different of the expression of tissue factor in renal cell carcinoma and the adjacent normal kidney tissue,the tissue factor may be used in diagnose and targeted treatment of renal cell carcinoma. It may be significant in the treatment of renal cell carcinoma.
方法:运用免疫组织化学MaxVision?法分别检测30例肾癌组织及15例作为对照的癌旁正常肾组织中组织因子蛋白的表达情况,并相互比较结果进行分析。
结果:组织因子在肾癌组织中的表达率90%(30例肾癌组织中有27例表达阳性)显著高于在癌旁正常组织中的表达率13.3%(15例癌旁正常肾组织中有2例表达阳性)。组织因子在肾癌及癌旁正常肾组织中的表达有显著性差异,具有统计学意义。
结论:组织因子与肾癌的发生、发展可能具有密切关系。根据组织因子蛋白在肾癌及癌旁正常肾组织中表达的差异,临床上可能能够利用组织因子蛋白对肾癌进行诊断和肿瘤靶向治疗。它可能在肾癌的治疗方面具有一定的临床价值。
Objective To inspect the expression of tissue factor (TF) in renal cell carcinoma and in adjacent normal renal tissues ,and to know the relationship of tissue factor expression with carcinogenesis and progression in renal cell carcinoma and its clinical applying value in renal cell carcinoma treatment.
Methods Detected the expression of tissue factor in 30 cases of renal cell carcinoma and 15 cases of the adjacent normal kidney tissue by MaxVision? immunhistochemistry method,then analyzed the results by comparing its.
Results The expression rate of tissue factor in renal cell carcinoma is 90%(27 cases are positive in 30 cases of renal cell carcinoma )was significantly higher than in the adjacent normal kidney tissue of 13.3%(2 cases are positive in 15 cases of the adjacent normal kidney tissue). The expression of tissue factor in renal cell carcinoma and the adjacent normal kidney tissue was sinnificantly different and the difference have statistics significance.
Conclusion Maybe there is a close relationship between tissue factor and renal cell carcinoma,According to the different of the expression of tissue factor in renal cell carcinoma and the adjacent normal kidney tissue,the tissue factor may be used in diagnose and targeted treatment of renal cell carcinoma. It may be significant in the treatment of renal cell carcinoma.
引文
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26. Ishibashi H, Nakagawa K, Onimaru M, et a1. Spl decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor,transforming growth factor betal,and tissue factor,and also cell growth and invasion activities[J].Cancer Res,2000,60(22):6531-6516.
27. Hu ZW,Garen A.Targeting tissue facior on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer.PNAS,2001.98(2l):12180
28. Hu ZW,Garen A.Intratumoral injection of adenoviral vectors encoding tumor—targeted immun0conjugates for cancer immunotherapy.PNAS,2000,97(16):9221.
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68. Hu ZW,Garen A.Targeting tissue facior on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer.PNAS,2001.98(2l):12180
69. Hu ZW,Garen A.Intratumoral injection of adenoviral vectors encoding tumor—targeted immun0conjugates for cancer immunotherapy.PNAS,2000,97(16):9221.
2. Carraway MS,Welty.IW0lf KE,Mifler DL,et a1.Blockade of tissue factor:Treatment for organ injury in established sepsis[J].Am J Rdspir Crit CareMed,2003,167(9):1200.
3. Callander N s,Varki N,Rao L-Immunohistochemical identification of tissue factor in solid tumors[J].cancer,1992,70(5):1194~1201.
4. Fernandez P M,Patierno S R,Rickles F R.Tissue factor and fibrin in tumor angiogenesis[J].Semin Thromb Hemost,2004,30(1):31~44.
5.项贵明,栗永萍,程天民,等.组织因子在不同人癌组织中的表达[J].中华肿瘤防治,2007,4(14):425～427.
6. Matsuyama M,Yoshimura R,Akioka K,et a1.Tissuefactor anti- sense oligonucleotides prevent renal ischemia-reperfusion injury[J]. Transplantation,2003,76:786～791.
7. Forster Y,Meye A,Albrecht S,et a1.Tissue specific expression and serum levels of human tissue factor in patients with urological cancer[J].Cancer Lett,2003,193:65～73.
8. Contrino J, Hair G, Kreutzer DL, et al. In situ detection of tissuefactor in vascular endothelial cells : correlation with the malignant phenotype of human breast disease[J].Nat Med, 1996, 2(2): 209~215.
9. Bartsch JE, Staren ED, Appert HE. Matrix metalloproteinase expression in breast cancer[J].J Surg Res, 2003, 110(2): 383~ 392.
10. Martin DM, WiigerMT, Prydz H. Tissue Factor and Biotechnology [J].Thrombosis Res, 1998, 90 (1) : 1~25.
11. Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor-2 by factor VIIa[J].Proc Natl Acad Sci U S A,2000,97:5255～5260.
12. Hjortoe GM, Petersen LC, Albrektsen T, et al. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 andresults in increased cell migration [J]. Blood, 2004,103:3029～3037.
13. Pendurthi UR, Allen KE, Ezban M, et al. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VII. tissue factor-induced signal transduction[J]. J Biol Chem,2000,275:14632～14641.
14. Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor[J].Proc Natl Acad Sci U S A.2001,98:7742～7747.
15. Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain [J]. J Biol Chem,2004,279:23038～23044.
16. sterud B, Flmgstad T. Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection:related to an unfavourable prognosis[J]. Thromb Haemost1983,49:5,7.
17. Chen J,Bierhaus A, Schiekofer S,et al .Tissue factor a receptor involved in the control of cellular properties. Including angiogenesis.Thromb Haemost,2001,86:334～345.
18. Miller DL, Welty-wolf KE, Carraway MS, et al. Extrinsic coagulation cascade blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide[J].Am J Respir Cell Mol Biol,2002,26:650～658.
19. Pawlinski R, Pedersen B, Schabbauer G, et al. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia[J]. Blood,2004,103:1342～1347.
20. Hamuro T, Kamikubo Y, Nakahara Y,et al. Human recombinant tissue factor pathway inhibitor induces apoptosis in cultured human endothelial cells[J].FEBS Lett, 1998 ,421(3):197-202.
21. Takano S, Tsuboi K, Tomono Y, et al.Tissue factor, osteopontin, alphavbeta3 integrin expression in microvasculature of gliomas associatedwith vascular endothelial growth factor expression[J]. Br J Cancer, 2000 ,82(12):1967-73.
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