核—壳及非对称聚合物功能微球制备研究
摘要
本论文将一种独特结构Surfmer用于分散聚合制备表面组成和性能对称的核-壳聚合物微球、利用UV光场制备表面组成和性能非对称的Janus微球。
利用自行合成具有抗菌功能的可聚合分散剂viologen单体-N-己基-N′-(4-乙烯基苄基)-4,4′-联吡啶溴氯(HVV),通过分散聚合使HVV接枝在粒子表面,通过一步法制备具有抗菌功能的单分散核-壳聚合物微球。针对聚合体系提出了核壳粒子形成的机理,并且分别探讨了各个反应参数对聚合体系的影响；采取多种途径来提高粒子的抗菌性能,包括提高粒子表面的HVV含量以及吸附本身具有抗菌效果的金属粒子。
另外,针对于常见的聚合物基体,工作中还提出一种普适性方法,通过紫外光引发的选择性表面改性制备两面球粒子。并且讨论了不同引发剂、不同单体对于制备各向异性粒子性能的影响。
A surfmer designed and synthesized in advance was introduced to St disperse polymerization to prepare symmetrical functional core-shell particles. Meanwhile, asymmetrical Janus particles on surface composition and/or property were prepared in UV field.
The dispersion polymerization of styrene was studied at 70℃with HVV which was tailored and syntheised as stabilizer, AIBN as initiator, mixing solvent of methanol/water as disperse media. And the monodisperse antibacterial core-shell microspheres were obtained by this single one-step polymerization. The formation mechinsm of core-shell particles was proposed as a result of HVV moderate hydrophile and reaction activity. What is more, the reaction parameters including dispersant concentration, monomer concentration, initiator concentration and disperse media were investigated which could make effects on microspheres diameter, diameter distributing, as well as thickness of core and shell. Several measures were carried out to enhance the HVV content combined on the surface of particles. The phenomenon was better by one-step feeding, two-step growth, adjusting solvent and adsorbing metal nanoparticles and so on.The more HVV grafted on particles surface meas better antibacterial activity.
In addition, polymeric Janus particles are obtained by UV-induced selective surface grafting modification, in advance of immobilizing photoinitiator and droping monomer solution on the surfaces exposing to UV light. And some related reaction factors such as initiator and monomer were studied in this system.
利用自行合成具有抗菌功能的可聚合分散剂viologen单体-N-己基-N′-(4-乙烯基苄基)-4,4′-联吡啶溴氯(HVV),通过分散聚合使HVV接枝在粒子表面,通过一步法制备具有抗菌功能的单分散核-壳聚合物微球。针对聚合体系提出了核壳粒子形成的机理,并且分别探讨了各个反应参数对聚合体系的影响；采取多种途径来提高粒子的抗菌性能,包括提高粒子表面的HVV含量以及吸附本身具有抗菌效果的金属粒子。
另外,针对于常见的聚合物基体,工作中还提出一种普适性方法,通过紫外光引发的选择性表面改性制备两面球粒子。并且讨论了不同引发剂、不同单体对于制备各向异性粒子性能的影响。
A surfmer designed and synthesized in advance was introduced to St disperse polymerization to prepare symmetrical functional core-shell particles. Meanwhile, asymmetrical Janus particles on surface composition and/or property were prepared in UV field.
The dispersion polymerization of styrene was studied at 70℃with HVV which was tailored and syntheised as stabilizer, AIBN as initiator, mixing solvent of methanol/water as disperse media. And the monodisperse antibacterial core-shell microspheres were obtained by this single one-step polymerization. The formation mechinsm of core-shell particles was proposed as a result of HVV moderate hydrophile and reaction activity. What is more, the reaction parameters including dispersant concentration, monomer concentration, initiator concentration and disperse media were investigated which could make effects on microspheres diameter, diameter distributing, as well as thickness of core and shell. Several measures were carried out to enhance the HVV content combined on the surface of particles. The phenomenon was better by one-step feeding, two-step growth, adjusting solvent and adsorbing metal nanoparticles and so on.The more HVV grafted on particles surface meas better antibacterial activity.
In addition, polymeric Janus particles are obtained by UV-induced selective surface grafting modification, in advance of immobilizing photoinitiator and droping monomer solution on the surfaces exposing to UV light. And some related reaction factors such as initiator and monomer were studied in this system.
引文
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