应用噬菌体控制牛及其饲养环境中大肠杆菌O157：H7的研究
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摘要
食源性致病菌一大肠杆菌O157:H7(Escherichia coli O157:H7)已成为危害人类健康的严重世界性公共卫生问题。牛及其饲养环境是大肠杆菌O157:H7的主要寄居场所及重要的传播源,在饲养场建立切实可行的控制策略可以有效地从源头上降低甚至完全消除致病菌的流行,减少和切断致病菌通过食物链和环境污染等途径传播,从而保障人类健康。目前,控制动物个体及其饲养环境中的病原菌尚无有效方法。本论文主要通过动物实验及体外裂解实验考察噬菌体的体内控制效果、裂解能力和宿主范围,并通过探索牛及其饲养环境中天然噬菌体的分布特性、变化规律及在同一生态系统中噬菌体与大肠杆菌O157:H7之间的相互作用关系,探讨和评价在饲养场实施噬菌体控制策略的有效性和可行性,为保障食品源头安全和环境安全创建一个高效、绿色、安全、无公害的生物防治平台。
以攻毒感染公牛为模型,选用直肠粪样法和直肠肛门连接处粘液拭子法监测大肠杆菌O157:H7的排泄量/检出率,考察四株噬菌体(rV5、wV7、wV8和wV11)口服给药的控制效果。综合对照组和给药组的检测结果,粪样的总阳性率(78.9%,202/256)显著高于拭子样本(62.9%,161/256;P＜0.01),二者之间的检测一致性为一般到中等(fairto moderate,κ=0.36～0.45);给药组口服噬菌体后,大肠杆菌O157:H7的总排泄量显著降低(P＜0.05)。粪样法比拭子法更能准确和有效地监测噬菌体的控制效果,口服四株噬菌体的混合制剂降低了牛大肠杆菌O157:H7的总排泄量。
以加拿大阿尔伯塔(Alberta)地区商业化肉牛和奶牛饲养场及临床病例分离获得的422株大肠杆菌O157:H7菌株为研究对象,采用噬菌体分型技术和脉冲场电泳技术(pulsed-field gel electrophoresis,PFGE)鉴定牛源分离株的噬型特征和基因型,通过建立微孔板分析法计算噬菌体裂解分离株的感染复数,评价噬菌体的宿主谱和裂解能力。噬菌体wV7、wV8、rV5和wV11的宽噬率分别为100%、96.4%、81.0%和76.1%;wV7裂解分离株的感染复数最低(0.004～0.006,P＜0.0001),其次为rV5和wV11(0.002～0.04,P＜0.0001),wV8最高(25～29,P＜0.0001);牛源分离株对rV5、wV11和wV8的易感性与其噬型和/或PFGE基因型有关。研究表明噬菌体的宿主谱和裂解能力的评价指标感染复数应同时作为筛选治疗性噬菌体的标准;口服给药的四株噬菌体可以有效裂解大部分受检菌株,不同饲养场的菌株对噬菌体wV8表现出不同的易感性,发现噬菌体rV5、wV11和wV8的易感性受其噬菌体表型和/或PFGE基因型影响,而噬菌体wV7的宿主谱和裂解能力不受菌株的噬菌体表型和PFGE基因型的影响,能够高效裂解所有受检分离株。
自2007年5～11月,采用初筛法和富集法从加拿大阿尔伯塔省南部两家商业化肉牛饲养场采集的个体直肠粪样、新鲜地面粪样、水槽中的饮用水和沉淀物样本(简称饮水样)以及地面粪尿泥浆样本中检测和分离天然大肠杆菌O157:H7噬菌体。噬菌体的总检出率为28.0%(239/855),其中粪尿泥浆样本检出率显著高于其它样本,达94.6%(35/37,P＜0.001);地面粪样中噬菌体的检出率呈周期性振荡变化,其中5月份最高(P＜0.05);另外,统计学分析显示若噬菌体在环境中的检出率较高时,大肠杆菌O157:H7在牛群中的检出率则较低(P＜0.01),Pearson相关性分析表明,同一个体粪样中噬菌体和大肠杆菌O157:H7的存在呈负向相关(r=-0.11,P＜0.05)。噬菌体广泛存在于牛场的动物个体及其周围环境中,粪尿泥浆中噬菌体的检出率高于地面粪样和饮水样,地面粪样中噬菌体检出率与大肠杆菌O157:H7呈现类似的周期性振荡变化规律;统计学分析显示存在于动物个体及其环境中的噬菌体均能显著降低大肠杆菌O157:H7在牛群中的检出率。
综上,本论文证明了噬菌体控制大肠杆菌O157:H7的有效性和可行性,初步揭示了饲养牛的生态系统中天然噬菌体检出率的变化规律为周期性振荡,统计分析表明了天然噬菌体能够降低致病菌在牛群中的检出率,为噬菌体控制策略在商业化饲养场的真正实施提供了可靠的事实依据和理论支持,开启了应用绿色、安全、无公害的生物防治手段有效保障食品源头安全和环境安全的先河。
The food-borne pathogen Escherichia coli O157:H7(E.coli O157:H7) is a significant public health concern.Cattle are recognized as primary reservoirs of E.coli O157:H7 and contaminated foods of bovine origin or vegetable products contaminated with bovine feces are important vehicles of human infection;therefore,effective interventions targeted at reducing shedding of E.coli O157:H7 by live cattle(preharvest) and presence of their environment are desirable.Currently there is no one preferred on-farm method that has given satisfactory and consistent results in reducing E.coli O157:H7 populations in cattle and their environment.The objectives of this research were to assess the use of bacteriophage (phages) as an on-farm strategy in mitigating occurrence of E.coli O157:H7 in feedlot cattle and their environment and thereby construct an effective,green,safe and pollution-free biological control stage to ensure food safety from origin and environment safety.
To evaluate oral administration of four bacteriophages(rV5,wV7,wV8,wV11) in mitigating the fecal shedding of E.coli O157:H7 by steers under production conditions,and compare fecal grab(FEC) and rectoanal mueosal swab(RAMS) techniques as sampling methods for surveillance of E.coli O157:H7 in conjunction with administration of a mitigation therapy.Overall,Oral treated steers presented fewer(P＜0.05) E.coli O157:H7 culture positive samples compared to control treatment.E.coli O157:H7 was detected more frequently(P＜0.01) by FEC than by RAMS.Kappa values(0.36 to 0.45) indicated only fair to moderate agreement between FEC and RAMS.Oral administration of bacteriophage could be an efficacious large-scale method for mitigating E.coli O157:H7 in cattle. Asessment of FEC samples by DP plus enrichment/IMS was more effective than RAMS/IMS for investigating E.coli O157:H7 mitigation strategies in E.coli O157:H7-challenged feedlot cattle.
To evaluate host range and lyric capability of four bacteriophages(rV5,wV7,wV8, wV11) against E.coli O157:H7(n=422) obtained from cattle and humans in Alberta, CANADA.Multiplicity of infection(MOI) of the four phages were estimated via mircoplate virulence assay.All bovine E.coli O157:H7 isolates were subject to pulsed field gel electrophoresis(PFGE) and phage typing(PT).Phage wV7 lyzed all human and bovine isolates irrespective of PFGE genotype or PT phenotype and exhibited the lowest MOI(0.004 to 0.006,P＜0.0001) of all phages.Phages rV5 and wV11 exhibited a lower MOI(0.002 to 0.04,P＜0.0001) than phage wV8(25 to 29) and a narrower host range than phages wV7 or wV8.Phages rV5,wV11 and wV8 lyzed 342(81.0%),321(76.1%) and 407(96.4%), respectively,of the 422 isolates.Excluding phage wV7,susceptibility of bovine E.coli O157:H7 isolates to phages rV5,w11 and wV8 was influenced by both by the PFGE genotype and/or PT phenotype of the targeted host.Each of the four phages studied in the present experiment exhibited activity against the majority of bovine and human E.coli O157:H7 isolates.Susceptibility of bovine E.coli O157:H7 to phage may differ among farms.Both lytic capability based on MOI and host range should be considered in the selection of therapeutic phage.The present work indicates that a four-phage cocktail should be equally effective at mitigating E.coli O157:H7 isolates of both cattle and human origin.
Distribution,fluctuation of endemic bacteriophages infecting E.coli O157:H7(PHAGE) and the relationship between PHAGE and shedding levels of E.coli O157:H7 by cattle were investigated in two commercial feedlots in southern Alberta.Between May and November 2007,10 pens of cattle were monitored by collection of pooled fecal pats(PAT),water with sediment from troughs(WAT),manure slurry from pen floor(when present,SLU) and rectal fecal samples from individual animals(FEC),collected at implantation and prior to slaughter. Bacteriophages infecting E.coli O157:H7 were recovered(by initial screening and/or enrichment) in 239 of 855 samples(109 PAT,76 FEC,19 WAT and 35 SLU).Overall, prevalence of PHAGE was highest(P＜0.001) in SLU.Recovery of PHAGE from PAT was highest(P＜0.05) in May.Overall,recovery did not differ(P＞0.10) between FEC and PAT.A higher prevalence of PHAGE in PAT or WAT was associated(P＜0.01) with reduced prevalence of E.coli O157:H7-positive FEC.There was a weak but significant negative correlation between isolation of PHAGE and E.coli O157:H7 in FEC(r＝-0.11; P＜0.05).These data demonstrate that the prevalence of PHAGE fluctuates periodically similar to that described for E.coli O157:H7.Endemic PHAGE were more prevalent in manure slurry than other environmental sources.The likelihood of fecal shedding of E.coli O157:H7 was reduced if cattle in the pen harbored PHAGE.
In conclusion,this study demonstrated that phages.as biological control agents have great potential to effectively control E.coli O157:H7 on farm and thus pioneered a green,safe, pollution-free strategy to ensure food safety from origin and environment safety.
以攻毒感染公牛为模型,选用直肠粪样法和直肠肛门连接处粘液拭子法监测大肠杆菌O157:H7的排泄量/检出率,考察四株噬菌体(rV5、wV7、wV8和wV11)口服给药的控制效果。综合对照组和给药组的检测结果,粪样的总阳性率(78.9%,202/256)显著高于拭子样本(62.9%,161/256;P＜0.01),二者之间的检测一致性为一般到中等(fairto moderate,κ=0.36～0.45);给药组口服噬菌体后,大肠杆菌O157:H7的总排泄量显著降低(P＜0.05)。粪样法比拭子法更能准确和有效地监测噬菌体的控制效果,口服四株噬菌体的混合制剂降低了牛大肠杆菌O157:H7的总排泄量。
以加拿大阿尔伯塔(Alberta)地区商业化肉牛和奶牛饲养场及临床病例分离获得的422株大肠杆菌O157:H7菌株为研究对象,采用噬菌体分型技术和脉冲场电泳技术(pulsed-field gel electrophoresis,PFGE)鉴定牛源分离株的噬型特征和基因型,通过建立微孔板分析法计算噬菌体裂解分离株的感染复数,评价噬菌体的宿主谱和裂解能力。噬菌体wV7、wV8、rV5和wV11的宽噬率分别为100%、96.4%、81.0%和76.1%;wV7裂解分离株的感染复数最低(0.004～0.006,P＜0.0001),其次为rV5和wV11(0.002～0.04,P＜0.0001),wV8最高(25～29,P＜0.0001);牛源分离株对rV5、wV11和wV8的易感性与其噬型和/或PFGE基因型有关。研究表明噬菌体的宿主谱和裂解能力的评价指标感染复数应同时作为筛选治疗性噬菌体的标准;口服给药的四株噬菌体可以有效裂解大部分受检菌株,不同饲养场的菌株对噬菌体wV8表现出不同的易感性,发现噬菌体rV5、wV11和wV8的易感性受其噬菌体表型和/或PFGE基因型影响,而噬菌体wV7的宿主谱和裂解能力不受菌株的噬菌体表型和PFGE基因型的影响,能够高效裂解所有受检分离株。
自2007年5～11月,采用初筛法和富集法从加拿大阿尔伯塔省南部两家商业化肉牛饲养场采集的个体直肠粪样、新鲜地面粪样、水槽中的饮用水和沉淀物样本(简称饮水样)以及地面粪尿泥浆样本中检测和分离天然大肠杆菌O157:H7噬菌体。噬菌体的总检出率为28.0%(239/855),其中粪尿泥浆样本检出率显著高于其它样本,达94.6%(35/37,P＜0.001);地面粪样中噬菌体的检出率呈周期性振荡变化,其中5月份最高(P＜0.05);另外,统计学分析显示若噬菌体在环境中的检出率较高时,大肠杆菌O157:H7在牛群中的检出率则较低(P＜0.01),Pearson相关性分析表明,同一个体粪样中噬菌体和大肠杆菌O157:H7的存在呈负向相关(r=-0.11,P＜0.05)。噬菌体广泛存在于牛场的动物个体及其周围环境中,粪尿泥浆中噬菌体的检出率高于地面粪样和饮水样,地面粪样中噬菌体检出率与大肠杆菌O157:H7呈现类似的周期性振荡变化规律;统计学分析显示存在于动物个体及其环境中的噬菌体均能显著降低大肠杆菌O157:H7在牛群中的检出率。
综上,本论文证明了噬菌体控制大肠杆菌O157:H7的有效性和可行性,初步揭示了饲养牛的生态系统中天然噬菌体检出率的变化规律为周期性振荡,统计分析表明了天然噬菌体能够降低致病菌在牛群中的检出率,为噬菌体控制策略在商业化饲养场的真正实施提供了可靠的事实依据和理论支持,开启了应用绿色、安全、无公害的生物防治手段有效保障食品源头安全和环境安全的先河。
The food-borne pathogen Escherichia coli O157:H7(E.coli O157:H7) is a significant public health concern.Cattle are recognized as primary reservoirs of E.coli O157:H7 and contaminated foods of bovine origin or vegetable products contaminated with bovine feces are important vehicles of human infection;therefore,effective interventions targeted at reducing shedding of E.coli O157:H7 by live cattle(preharvest) and presence of their environment are desirable.Currently there is no one preferred on-farm method that has given satisfactory and consistent results in reducing E.coli O157:H7 populations in cattle and their environment.The objectives of this research were to assess the use of bacteriophage (phages) as an on-farm strategy in mitigating occurrence of E.coli O157:H7 in feedlot cattle and their environment and thereby construct an effective,green,safe and pollution-free biological control stage to ensure food safety from origin and environment safety.
To evaluate oral administration of four bacteriophages(rV5,wV7,wV8,wV11) in mitigating the fecal shedding of E.coli O157:H7 by steers under production conditions,and compare fecal grab(FEC) and rectoanal mueosal swab(RAMS) techniques as sampling methods for surveillance of E.coli O157:H7 in conjunction with administration of a mitigation therapy.Overall,Oral treated steers presented fewer(P＜0.05) E.coli O157:H7 culture positive samples compared to control treatment.E.coli O157:H7 was detected more frequently(P＜0.01) by FEC than by RAMS.Kappa values(0.36 to 0.45) indicated only fair to moderate agreement between FEC and RAMS.Oral administration of bacteriophage could be an efficacious large-scale method for mitigating E.coli O157:H7 in cattle. Asessment of FEC samples by DP plus enrichment/IMS was more effective than RAMS/IMS for investigating E.coli O157:H7 mitigation strategies in E.coli O157:H7-challenged feedlot cattle.
To evaluate host range and lyric capability of four bacteriophages(rV5,wV7,wV8, wV11) against E.coli O157:H7(n=422) obtained from cattle and humans in Alberta, CANADA.Multiplicity of infection(MOI) of the four phages were estimated via mircoplate virulence assay.All bovine E.coli O157:H7 isolates were subject to pulsed field gel electrophoresis(PFGE) and phage typing(PT).Phage wV7 lyzed all human and bovine isolates irrespective of PFGE genotype or PT phenotype and exhibited the lowest MOI(0.004 to 0.006,P＜0.0001) of all phages.Phages rV5 and wV11 exhibited a lower MOI(0.002 to 0.04,P＜0.0001) than phage wV8(25 to 29) and a narrower host range than phages wV7 or wV8.Phages rV5,wV11 and wV8 lyzed 342(81.0%),321(76.1%) and 407(96.4%), respectively,of the 422 isolates.Excluding phage wV7,susceptibility of bovine E.coli O157:H7 isolates to phages rV5,w11 and wV8 was influenced by both by the PFGE genotype and/or PT phenotype of the targeted host.Each of the four phages studied in the present experiment exhibited activity against the majority of bovine and human E.coli O157:H7 isolates.Susceptibility of bovine E.coli O157:H7 to phage may differ among farms.Both lytic capability based on MOI and host range should be considered in the selection of therapeutic phage.The present work indicates that a four-phage cocktail should be equally effective at mitigating E.coli O157:H7 isolates of both cattle and human origin.
Distribution,fluctuation of endemic bacteriophages infecting E.coli O157:H7(PHAGE) and the relationship between PHAGE and shedding levels of E.coli O157:H7 by cattle were investigated in two commercial feedlots in southern Alberta.Between May and November 2007,10 pens of cattle were monitored by collection of pooled fecal pats(PAT),water with sediment from troughs(WAT),manure slurry from pen floor(when present,SLU) and rectal fecal samples from individual animals(FEC),collected at implantation and prior to slaughter. Bacteriophages infecting E.coli O157:H7 were recovered(by initial screening and/or enrichment) in 239 of 855 samples(109 PAT,76 FEC,19 WAT and 35 SLU).Overall, prevalence of PHAGE was highest(P＜0.001) in SLU.Recovery of PHAGE from PAT was highest(P＜0.05) in May.Overall,recovery did not differ(P＞0.10) between FEC and PAT.A higher prevalence of PHAGE in PAT or WAT was associated(P＜0.01) with reduced prevalence of E.coli O157:H7-positive FEC.There was a weak but significant negative correlation between isolation of PHAGE and E.coli O157:H7 in FEC(r＝-0.11; P＜0.05).These data demonstrate that the prevalence of PHAGE fluctuates periodically similar to that described for E.coli O157:H7.Endemic PHAGE were more prevalent in manure slurry than other environmental sources.The likelihood of fecal shedding of E.coli O157:H7 was reduced if cattle in the pen harbored PHAGE.
In conclusion,this study demonstrated that phages.as biological control agents have great potential to effectively control E.coli O157:H7 on farm and thus pioneered a green,safe, pollution-free strategy to ensure food safety from origin and environment safety.
引文
[1]Tarr P 1,Gordon C A,Chandler W L.Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome[J].Lancet,2005,365(9464):1073-1086.
[2]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157-.H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[3]Rangel,J M,Sparling,P H,Crowe C,et al.Epidemiology of Escherichia coli O157:H7 outbreaks.United states,1982-2002[J].Emerging Infectious Diseases,2005,11(4):603-609.
[4]Stevens M P,van Diemen P M,Dziva F,et al.Options for the control of enterohaemorrhagic Escherichia coli in ruminants[J].Microbiology,2002,148(Pt12):3767-3778.
[5]Chapman P A,Malo A T,Siddons C A,et al.Use of commercial enzyme immunoassays and immunomagnetic separation systems for detecting Escherichia coli O157 in bovine fecal samples[J].Applied and Environmental Microbiology,1997,63(7):2549-2553.
[6]Mechie S C,Chapman P A,Siddons C A.A fifteen month study of Escherichia coli O157:H7 in a dairy herd[J].Epidemiology and Infection,1997,118(1):17-25.
[7]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[8]Sulakvelidze A,Alavidze Z,Morris JG Jr.Bacteriophage therapy[J].Antimicrobial Agents and Chemotherapy,2001,45(3):649-659.
[9]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[10]Brüssow H.Phage therapy:the Escherichia coli experience[J].Microbiology,2005,151(Pt7):2133-2140.
[11]Jones J B,Jackson L E,Balogh B,et al.Bacteriophages for plant disease control[J].Annual Review of Phytopathology,2007,45:245-262.
[12]Greer G G.Bacteriophage control of foodborne bacteria[J].Journal of Food Protection,2005,68(5):1102-1111.
[13]Abuladze T,Li M,Menetrez M Y,et al.Bacteriophages reduce experimental contamination of hard surfaces,tomato,spinach,broccoli,and ground beef by Escherichia coli O157:H7[J].Applied and Environmental Microbiology,2008,74(20):6230-6238.
[14]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogens and Disease,2008,5(2):183-191.
[15]Niu Y D,Xu Y,McAllsiter,T A,et al.Comparison of fecal versus rectoanal mucosal swab sampling for detecting Escherichia coliO157:H7 in experimentally inoculated cattle used in assessing bacteriophage as a mitigation strategy[J].Journal of Food Protection,2008,71(4):691—698.
[16]Viscardi M,Perugini G A,Auriemma C,et al.Isolation and characterisation of two novel coliphages with high potential to control antibiotic-resistant pathogenic Escherichia coli (EHEC and EPEC)[J].International Journal of Antimicrobial Agents,2008,31(2):152-157.
[1]Riley L W,Remis R S,Helgerson S D,et al.Hemorrhagic colitis associated with a rare Escherichia coli serotype[J].The New England Journal of Medicine,1983,308(12):381-385.
[2]Wells J G,Davis B R,Wachsmuth 1 K,et al.Laboratory investigation of hemorrhagic colitis outbreaks associated with a rare Escherichia coli serotype[J].Journal of Clinical Microbiology,1983,18(3):512-520.
[3]Whittam T S,Wolfe M L,Wachsmuth I K,et al.Clonal relationships among Escherichia coli strains that cause hemorrhagic colitis and infantile diarrhea[J].Infection and Immunity,1993,61(5):1619-1629.
[4]Reid S D,Herbelin C J,Bumbaugh A C,et al.Parallel evolution of virulence in pathogenic Escherichia coli[J].Nature,2000,406:64-67.
[5]Shaikh N,Tarr P I.Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages:integrations,excisions,truncations,and evolutionary implications[J].Journal of Bacteriology,2003.185(12):3596-3605.
[6]Perna N T,Plunkett G,Burland V,et al.Genome sequence of enterohaemorrhagic Escherichia coli O157:H7[J].Nature,2001,409:529-533.
[7]Griffin P M,Tauxe R V.The epidemiology of infections caused by Escherichia coli O157:H7,other enterohemorrhagic E.coli,and the associated hemolytic uremic syndrome[J].Epidemiology Review,1991,13:60-98.
[8]Paton J C,Paton,A W.Shiga toxigenic Escherichia coli infections[J].Science & Medicine,2000.7(3):28-37.
[9]Su C,Brandt L J.Escherichia coli O157:H7 infection in humans[J].Annals of Internal Medicine,1995,123(9):698-714.
[10]Boyce T G,Swerdlow D L,Griffin P M.Escherichia coli O157 and the haemolytic-uraemic syndrome[J].The New England Journal of Medicine,1995,333(6):364-368.
[11]Lior H.Classification of Escherichia coli[M],pp.31-72.In Gyles C L(ed.),Escherichia coli in domestic animals and humans.CAB International,Wallingford,UK.,1994.
[12]Farmer J J,Davis B R.H7 antiserum-sorbitol fermentation medium for Escherichia coli O157:H7 associated with haemorrhagic colitis[J].Journal of Clinical Microbiology,1985,22(4):620-625.
[13]Thompson J S,Hodge D S,Borczyk A A.Rapid biochemical test to identify verocytotoxin-positive strains of Escherichia coli serotype O157[J].Journal of Clinical Microbiology,1990,28(10):2165-2168.
[14]Doyle M P,Schoeni J L.Survival and growth characteristics of Escherichia coli associated with haemolytic colitis[J].Applied and Environmental Microbiology,1984,48(4):855-856
[15]Nataro J P,Kaper J B.Diarrheagenic Escherichia coli[J].Clinical Microbiological Reviews,1998.11(1):142-201.
[16]Vanselow B A,Krause D O,McSweeney C S.The Shiga toxin-producing Escherichia coli,their ruminant hosts,and potential on-farm interventions:a review[J].Australian Journal of Agriculture Research,2005,56(3):219-214.
[17]McQuigge M,Ellis A,Stratton,et al.A large outbreak of E.coli O157:H7 and Campylobacter infections due to contaminated municipal drinking water[C].'4th International Symposium and Workshop on "Shiga Toxin(Verotoxin)-Produeing infections'.Kyoto,Japan.(VTEC 2000,C/o The Convention:Minarni-Aoyama,Minato-ku,Tokyo),2000.
[18]PHAC.C-EnterNet 2006 Annual Report[EB],2007[2007,11,19].Available at:http://www.phac-aspc.gc.ca/publicat/2OO7/c-enternet06/pdf/O6-areport_e.pdf.
[19]Michel P J B,Wilson S W,Martin R C,et al.Estimation of the under-reporting rate for the surveillance of Escherichia coli O157:H7 cases in Ontario,Canada[J].Epidemiology and Infection,2000,125(1):35-45.
[20]Majowicz S E,Edge V L,Fazil A,et al.Estimating the under-reporting rate for infectious gastrointestinal illness in Ontario[J].Canadian Journal of Public Health,2005,96(3):178-181.
[21]李洪卫,逢波,景怀琦等.徐州市2002年肠出血性大肠埃希菌O157:H7感染性腹泻的调查[J].中华流行病学杂志,2002,23(2):119-122.
[22]汪华.肠出血性大肠杆菌O157:H7流行特征和控制对策研究[J].医学研究通讯,2005.34(5):24-25.
[23]汪华,景怀琦,李洪卫等.江苏省淮北地区肠出血性大肠埃希菌O157:H7感染性腹泻并发急性肾衰的研究[J].中华流行病学杂志,2004,25(11):938-940.
[24]叶方友,林君芬,江夏明.温岭市首例肠出血性大肠杆菌O157:H7感染性腹泻的流行病学调查[J].预防医学情报杂志,2002,18(2):126.
[25]许文香,陈翠平,增明.肠出血大肠埃希菌O157:H7与食品安全[J].卫生研究,2006,35(4):527-528.
[26]张淑红,申志新,关文英等.河北省食品中大肠杆菌O157:H7分布及毒力研究[J].中国卫生检疫杂志,2007,17(1):120-122.
[27]王燕.大肠杆菌O157:H7感染流行概况[J].微生物学免疫学进展,2008,36(1):51-58.
[28]Belongia E A,Osterholm M T,Soler J T,et al.Transmission ofEscherichia coli O157:H7 infection in Minnesota child day-care facilities[J].The Journal of the American Medical Association,1993,269(7):883-888.
[29]Chalmers R M,Aird H,Bolton F J.Waterborne Escherichia coli O157[J].Journal of Applied Microbiology,2000,88:124-132.
[30]Verma A,Bolton F J,Fiefield D,et al.An outbreak of E.coli O157 associated with a swimming pool:an unusual vehicle of transmission[J].Epidemiology and Infecttion,2007,135(6):989-992.
[31]Armstrong G L,Hollingsworth J,Morris Jr J G.Emerging foodborne pathogens:Escherichia coli O157:H7 as a model of entry of a new pathogen into the food supply of the developed world[J].Epidemiologic Reviews,1996,18(1):20-51.
[32]Ogden l D,Hepburn N F,Macrae M,et al.Long-term survival of Escherichia coli O157 on pasture following an outbreak associated with sheep at a scout camp[J].Letters in Applied Microbiology,2002,34(2):100-104.
[33]Rangel J M,Sparling P H,Crowe C,et al.Epidemiology of Escherichia coli O157:H7 outbreaks,United States,1982-2002[J].Emerging Infectious Disease,2005,11(4):603-309.
[34]Bell B P,Goldoft M,Griffin P M,et al.A multistate outbreak of Escherichia coli O157:H7-associated bloody diarrhea and hemolytic uremic syndrome from hamburgers.The Washington Experience[J].The Journal of America Medicine Association,1994,272(17):1349-1353.
[35]Willshaw G A,Thirlwell J,Jones A P,et al.Vero cytotoxin-producing Escherichia coli O157 in beef burgers linked to an outbreak of diarrhea,haemorrhagic colitis and haemolytic ureamic syndrome in Britain[J].Emerging Infectious Disease,1994,3(4):561-565.
[36]Stevenson J,Hanson S.Outbreak of Escherichia coli O157 phage type 2 infection associated with eating precooked meats[J].Communicable disease report.CDR review,1996,6(8):R116-R118.
[37]Besser R E,Lett S M,Weber J T,et al.An outbreak of diarrhea and hemolytic uremic syndrome from Escherichia coli O157:H7 in fresh-pressed apple cider[J].The Journal of America Medicine Association,1993,269(17):2217-2220.
[38]Cody S H,Glynn M K,Farrar J A,et al.An outbreak of Escherichia coli O157:H7 infection from unpasteurized commercial apple juice[J].Annals of Internal Medicine,1999,130(3):202-209.
[39]Ackers M L,Mahon B E,Leahy E,et al.An outbreak of Escherichia coli O157:H7 infections associated with leaf lettuce consumption[J].The Journal of Infectious Disease,1998,177(6):1588-1593.
[40]Hilborn E D,Mermin J H,Mshar P A,et al.A multistate outbreak of Escherichia coli O157:H7 infections associated with consumption of mesclun lettuce[J].Archives of Internal Medicine,1999,159(15):1758-1764.
[41]Todd B.Outbreak:E.coli O157:H7[J].The American journal of nursing,2007,107(2):29-32.
[42]Liptakova A,Siegfried L,Rosocha J,et al.A family outbreak of haemolytic uraemic syndrome and haemorrhagic colitis caused by verocytotoxigenic Escherichia coli O157 from unpasteurised cow's milk in Slovakia[J].Clinical Microbiology and Infection,2004,10(6):576-578.
[43]Espie E,Vaillant V,Mariani-Kurkdjian P,et al.Escherichia coli O157 outbreak associated with fresh unpasteruized goats' cheese[J].Epidemiology and Infection,2006,134(1):143-146.
[44]Beutin L,Geier D,Steinruck H,et al.Prevalence and some properties of Verotoxin (Shiga-like toxin) -producing Escherichia coli in 7 different species of healthy domestic animals[J],Journal of Clinical Microbiology,1993,31(9):2483-2488.
[45]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7-A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[46]Hancock D,Besser T,LeJeune J,et al.The control of VTEC in the animal reservoir[J].International Journal of Food Microbiology,2001.66(1-2):71-78.
[47]Rasmussen M A,Casey T A.Environmental and food safety aspects of Escherichia coli O157:H7 infections in cattle[J].Critical Review in Microbiology,2001,27(2):57-73.
[48]Renter D G,Sargeant J M.Enterohemorrhagic Escherichia coli O157:epidemiology and ecology in bovine production environments[J].Animal Health Research Reviews.2002,3(2):83-94.
[49]Serna A,Boedeker E C.Pathogenesis and treatment of shiga toxin-producing Escherichia coli infections[J].Current Opinion in Gastroenterology,2008.24(1):38-47.
[50]Buchanan R L,Doyle M P.Foodborne disease significance of Escherichia coli O157:H7 and other enterohemorrhagic E.coli[J].Food Technology,1997,51(10):69-76.
[51]Jay M T,Garrett V,Mohle-Boetani J C,et al.A multistate outbreak of Escherichia coli O157:H7 infection linked to consumption of beef tacos at a fast-food restaurant chain[J].Clinical Infectious Disease,2004,39(1):1-7.
[52]Laine E S,Scheftel J M,Boxrud D J,et al.Outbreak of Escherichia coli O157:H7 infections associated with nonintact blade-tenderized frozen steaks sold by door-to-door vendors[J].Journal of Food Protection,2005,68(6):1198-1202.
[53]Maruzumi M,Morita M,Matsuoka Y,et al.Mass food poisoning caused by beef offal contaminated by Escherichia coli O157[J].Japanese Journal of Infectious Disease,2005,58(6):397.
[54]Honish L,Zazulak I,Mahabeer R,et al.Outbreak of Escherichia coli O157:H7 gastroenteritis associated with consumption of beef donairs,Edmonton,Alberta,May-June 2006[J].Canadian Communicable Disease Report,2007,33(2):14-19.
[55]Licence K,Oates K R,Synge B A,et al.An outbreak of E.coli O157 infection with evidence of spread from animals to man through contamination of a private water supply[J].Epidemiology and Infection,2001,26(1):135-138.
[56]Spencer J L,Guan J.Public health implications related to spread of pathogens in manure from livestock and poultry operations[J].Methods in Molecular Biology (Clifton,N.J.),2004,268:503-515.
[57]Renwick S A,Wilson J B,Clarke R C,et al.Evidence of direct transmission of Escherichia coli O157:H7 infection between calves and a human[J].The Journal of Infectious Disease,1993,168(3):792-793.
[58]Synge B A,Hopkins G F,Reilly W J.Possible link between cattle and E.coli O157 infection in a human[J].The Veterinary Record,1993,133(20):507.
[59]Rice D H,Hancock D D,Besser T E.Verotoxigenic E.coli O157 colonization of wild deer and range cattle[J].The Veterinary Record,1995,137(20):524.
[60]Crump J A,Sulka A C,Langer A J,et al.An outbreak of Escherichia coli O157:H7 infections among visitors to a diary farm[J].The New England Journal of Medicine,2002,347(80):555-560.
[61]Ostroff S M,Kobayashi J M,Lewis J H.Infections with Escherichia coli O157:H7 in Washington State.The first year of statewide disease surveillance[J].The Journal of America Medical Association,1989,262(3):355-359.
[62]Martin D L.MacDonald K L,White K E,et al.The epidemiology and clinical aspects of the hemolytic-uremic syndrome in Minnesota[J].The New England Journal of Medicine,1990,323(17):1161-1167.
[63]Hancock D D,Besser T E,Rice D H,et al.A longitudinal study of Escherichia coli O157 in fourteen cattle herds[J].Epidemiology and Infection,1997,118(2):193-195.
[64]Cizek A,Alexa P,Liter(?)k l,et al.Shiga toxin-producing Escherichia coli O157 in feedlot cattle and Norwegian rats from a large-scale farm[J].Letters in Applied Microbiology,1999,28 (6):435-439.
[65]Shinagawa K,Kanehira M,Omoe K,et al.Frequency of Shiga toxin-producing Escherichia coli in cattle at a breeding farm and at a slaughterhouse in Japan[J].Veterinary Microbiology,2000.76(3):305-309.
[66]Gannon V P J,Graham T A,King R,et al.Escherichia coli O157:H7 infection in cows and calves in a beef cattle herd in Alberta,Canada[J].Epidemiology and Infection,2002,129(1):163-172.
[67]Hussein H S,Thran B H,Hall M R,et al.Verotoxin-producing Escherichia coli in culled beef cows grazing rangeland forages[J].Experimental Biology and Medicine,2003,228(4):352-357.
[68]Schurman R D,Hariharan H,Heaney S B,et al.Prevalence and characteristics of Shiga toxin-producing Escherichia coli in beef cattle slaughtered on Prince Edward lsland[J].Journal of Food Protection,2000,63(11):1583-1586.
[69]Thran B H,Hussein H S,Hall M R,et al.Shiga toxin-producing Escherichia coli in beef heifers grazing an irrigated pasture[J].Journal of Food Protection,2001,64(10):1613-1616.
[70]Ezawa A,Gocho F,Kawata K,et al.High prevalence of enterohemorrhagic Escherichia coli (EHEC) O157 from cattle in selected regions of Japan[J].Journal of Veterinary Medical Science,2004,66(5):585-587.
[71]Smith D R,Gray J T,Moxley R A,et al.A diagnosis strategy to determine the Shiga toxin-producing Escherichia coli O157 status of pens of feedlot cattle[J].Epidemiology and Infection,2004,132(2):297-302.
[72]Pearce M C,Jenkins C,Vali L,et al.Temporal shedding patterns and virulence factors of Escherichia coli serogroups O26,O103,O111,O145,and O157 in a cohort of beef calves and their dams[J].Applied and Environmental Microbiology,2004,70(3):1708-1716.
[73]Reinstein S,Fox J T,Shi X,et al.Prevalence of Escherichia coli O157.H7 in the American bison(Bison bison) [J].Journal of Food Protection,2007,70 (11):2555-2560.
[74]Hancock D D,Besser T E,Kinsell M L,et al.The prevalence of Escherichia coli O157.H7 in dairy and beef cattle in Washington State[J].Epidemiology and Infection,1994,113(2):199-207.
[75]Stanford K,Croy D,Bach S J,et al.Ecology of Escherichia coli O157:H7 in commercial dairies in Southern Alberta[J].Journal of Dairy Science,2005,88(12):4441-4451.
[76]Hancock D D,Rice D H,Thomas L A,et al.Epidemiology of Escherichia coli O157 in feedlot cattle[J].Journal of Food Protection,1997,60(5):462-465.
[77]LeJeune J T,Besser T E,Rice D H,et al.Longitudinal study of fecal shedding of Escherichia coli O157:H7 in feedlot cattle:Predominance and persistence of specific clonal types despite massive cattle population turnover[J].Applied and Environmental Microbiology,2004,70(1):377-384.
[78]Padola N L,Sanz M E,Blanco J E,et al.Serotypes and virulence genes of bovine Shiga toxigenic Escherichia coli (STEC) isolated from a feedlot in Argentina[J].Veterinary Microbiology,2004.100(1-2):3-9.
[79]Elder R O,Keen J E,Siragusa G R,et al.Correlation of enterohemorrhagic Escherichia coli O157 prevalence in feces,hides,and carcasses of beef cattle during processing[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):2999-3003.
[80]Renter D G,Checkley S L,Campbell J,et al.Shiga toxin-producing Escherichia coli in the feces of Alberta feedlot cattle[J].Canadian Journal of Veterinary Research,2004,68(2):150-153.
[81]Hussein S H,Bollinger L M.Prevalence of Shiga toxin-producing Escherichia coli in beef cattle[J].Journal of Food Protection,2005,68(10):2224-2241.
[82]Cobbold R,Desmarchelier P.Horizontal transmission of Shiga toxin-producing Escherichia coli within groups of dairy calves[J].Applied and Environmental Microbiology,2002,68(8):4148-4152.
[83]Barham A R,Barham B L,Johnson A K,et al.Effects of the transportation of beef cattle from the feedyard to the packing plant on prevalence levels of Escherichia coli O157 and Salmonella spp[J].Journal of Food Protection,2002,65(2):280-283.
[84]Tutenel A V,Pierard D,Van Hoof J,et al.Molecular characterization of Escherichia coli O157 contamination routes in a cattle slaughter house[J].Journal of Food Protection,2003,66(9):1564-1569.
[85]Nastasijevic 1,Mitrovic R,Buncic S.Occurrence of Escherichia coli O157 on hides of slaughtered cattle[J].Letters in Applied Microbiology,2008,46(1):126-131.
[86]Zhao T,Doyle M P,Shere J,et al.Prevalence of enterohemorrhagic Escherichia coli O157:H7 in a survey of dairy herds[J].Applied and Environmental Microbilogy,1995,61 (4):1290-1293.
[87]Chapman P A,Malo A T,Siddons C A,et al.Use of commercial enzyme immunoassays and immunomagnetic separation systems for detecting Escherichia coli O157 in bovine fecal samples[J].Applied and Environmental Microbiology,1997,63(7):2549-2553.
[88]Mechie S C,Chapman P A,Siddons C A.A fifteen month study of Escherichia coli O157:H7 in a dairy herd[J].Epidemiology and Infection,1997,118(1):17-25.
[89]Pruimboom-Brees 1 M,Morgan T W,Ackermann M R,et al.Cattle lack vascular receptors for Escherichia coli O157:H7 Shiga toxins[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(19):10235-10329.
[90]Hoey D E,Currie C,Else R W,et al.Expression of receptors for verotoxin 1 from Escherichia coli O157 on bovine intestinal epithelium[J].Journal of Medical Microbiology,2002,51(2):143-149.
[91]Lingwood C A.Glycolipid receptors for verotoxin and Helicobacter pylori:role in pathology[J].Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease,1999,1455(2):375-386.
[92]Endo Y,Tsurugi K,Yutsudo T,et al.Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes.RNA N-glycosidase activity of the toxins[J].European Journal of Biochemistry,1988,171(1-2):45-50.
[93]Boerlin P,McEwen S A,Boerlin-Petzold F,et al.Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans[J].Journal of Clinical Microbiology,1999,37(3):497-503.
[94]Hoey D E,Sharp L,Currie C,et al.Verotoxin 1 binding to intestinal crypt epithelial cells results in localization to lysosomes and abrogation of toxicity [J].Cellular Microbiology,2003,5(2):85-97.
[95]Fegan N,Vanderlinde P,Higgs G,et al.The prevalence and concentration of Escherichia coli O157 in faeces of cattle from different production systems at slaughter[J].Journal of Applied Micriobiology,2004,97(2):362-370.
[96]Widiasih D A,Ido N,Omoe K,et al.Duration and magnitude of faecal shedding of Shiga toxin-producing Escherichia coli from naturally infected cattle[J].Epidemiology and Infection,2004.132(1):67-75.
[97]Naylor.S W,Low J C,Besser T E,et al.Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichi coli O157:H7 in the bovine host[J].Infection and Immunity,2003,71(3):1505-1512.
[98]Matthews L,Low J C,Gaily D L,et al.Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(3):547-552.
[99]Omisakin F,MacRae M,Ogden I D,et al.Concentration and prevalence of Escherichia coli O157 in cattle feces at slaughter[J].Applied and Environmental Microbiology,2003,69(5):2444-2447.
[100]Low J C,McKendrick I J,McKechnie C,et al.Rectal carriage of enterohemorrhagic Escherichia coli O157 in slaughtered cattle[J].Applied and Environmental Microbiology,2005,71(1):93-97.
[101]Cray W C,Moon H W.Experimental infection of calves and adult cattle with Escherichia coli O157:H7[J].Applied and Environmental Microbiology,1995,61(4):1586-1590.
[102]Sanderson M W,Besser T E,Gay J M,et al.Fecal Escherichia coli O157:H7 shedding patterns of orally inoculated calves[J].Veterinary Microbiology,1999,69(3):199-205.
[103]Van Baale M J,Sargeant J M,Gnad D P,et al.Effect of forage or grain diets with or without monensin on ruminal persistence and fecal Escherichia coli O157:7 in cattle[J].Applied and Environmental Microbiology,2004,70(9):5336-5342.
[104]Faith N G,Shere J A,Brosch R,et al.Prevalence and clonal nature of Escherichia coli O157:H7 on dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1996,62(5):1519—1525.
[105]Hancock D D,Besser T E,Rice D H,et al.Multiple sources of Escherichia coli O157 in feedlots and dairy farms in the northwestern USA[J].Preventive Veterinary Medicine,1998,35(1):11-19.
[106]Shere J A,Bartlett K J,Kaspar C W.Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1998,64(4):1390-1399.
[107]Sargeant J M,Gillespie J R.Oberst R D,et al.Results of a longitudinal study of the prevalence of Escherichia coli O157:H7 on cow-calf farms[J].American Journal of Veterinary Research,2000,61(11):1375-1379.
[108]Van Donkersgoed J,Berg J,Potter A,et al.Environmental sources and transmission of Escherichia coli O157 in feedlot cattle[J].The Canadian Verterinary Journal,2001,42(9):714-720.
[109]Wang G,Doyle M P.Survival of enterohemorrhagic Escherichia coli O157:H7 in water.Journal of Food Protection,1998,61(6):662-667.
[110]Lynn T V,Hancock D D,Besser T E,et al.The occurrence and replication of Escherichia coli in cattle feeds[J].Journal of Dairy Science,1998,81(4):1102-1108.
[111]Dodd C C,Sanderson M W,Sargeant J M,et al.Prevalence of Escherichia coli O157 in cattle feeds in Midwestern feedlots[J].Applied and Environmental Microbiology,2003,69(9):5243-5247.
[112]Bach S J,Selinger L J,Stanford K,et al.Effect of supplementing corn-or barley-based feedlot diets with canola oil on faecal shedding of Escherichia coli O157:H7 by steers[J].Journal of Applied Microbiology,2005,98(2):464-475.
[113]McAllister T A,Bach S J,Stanford K.Shedding of Escherichia coli O157:H7 by cattle fed diets containing Monensin or Tylosin[J].Journal of Food Protection,2006,69(9):2075-2083.
[114]Fenlon D R,Wilson J.Growth of Escherichia coli O157 in poorly fermented laboratory silage:a possible environmental dimension in the epidemiology of E.coli O157[J].Letters in Applied Microbiology,2000,30(2):118-121.
[115]Wang G,Zhao T,Doyle M P.Fate of enterohemorrhagic Escherichia coli O157:H7 in bovine feces[J].Applied and Environmental Microbiology,1996,62(7):2567-2570.
[116]Kudva 1 T,Blanch K,Hovde C J.Analysis of Escherichia coli O157:H7 Survival in Ovine or Bovine Manure and Manure Slurry[J].Applied and Environmental Microbiology,1998,64(9):3166-3174.
[117]Fenlon D R,Ogden I D,Vinten A,et al.The fate of Escherichia coli and Escherichia coli O157 in cattle slurry after application to the land.Journal of Applied Microbiology,2000,88(29):149S-156S
[118]Berry E D,Miller D N.Cattle feedlot soil moisture and manure content:Ⅱ.Impact on Escherichia coli O157[J].Journal of Environmenal Quality,2005,34(2):656-663.
[119]Jiang X,Morgan J,doyle M P.Fate of Escherichia coli O157:H7 in manure-amended soil[J].Applied and Environmental Microbiology,2002,68(5):2605-2609.
[120]Wells J E,Berry E D,Varel V H.Effects of common forage phenolic acids on Escherichia coli O157:H7 viability in bovine feces[J].Applied and Environmental Microbiology.2005,71(12):7974-7979.
[121]Fremaux B,Delignette-Muller M L,Prigent-Combaret C,et al.Growth and survival of non-O157:H7 shiga-toxin-producing Escherichia coli in cow manure[J].Journal of Applied Microbiology,2006,102(1):89-99.
[122]Van Donkersgoed J,Graham T,Gannon V.The prevalence of verotoxins,Escherichia coli O157:H7,and Salmonella in the feces and rumen of cattle at processing[J].Canadian Veterinary Journal,1999,40(5):332-338.
[123]Chapman P A.Sources of Escherichia coli O157 and experiences over the past 15 years in Sheffield.UK[J].Journal of Applied Microbiology,2000,88(29):51S-60S.
[124]Edrington T S,Callaway T R,Hallford D M,et al.Effects of exogenous melatonin and tryptophan on fecal shedding of E.coli O157:H7 in cattle[J].Microbial Ecology,2008,55(3):553-560.
[125]Keene W E,Sazie K,Kok J,et al.An outbreak of Escherichia coli O157:H7 infections traced to jerky made from deer meat[J].The Journal of the American Medical Association,1997,277(15):1229-1231.
[126]Kudva I T,Hatfield P G,Hovde C J.Characterization of Escherichia coli O157:H7 and other shiga toxin-producing E.coli serotypes from sheep[J].Journal of Clinical Mcirobilogy,1997,35(4):298-299.
[127]Stevens M P,van Diemen P M,Dziva F,et al.Options for the control of enterohaemorrhagic Escherichia coli in ruminants[J].Microbiology,2002,148(Pt12):3767-3778.
[128]LeJeune J T,Wetzel A N.Preharvest control of Escherichia coli O157 in cattle[J].Journal of Animal Science,2007,85(13 Suppl):E73-80.
[129]CDC.Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food-10 sites,United States,2004[EB].MMWR Morbidity and mortality weekly report,2005,54(14):352-356.
[130]USDA.2005.FSIS Ground beef sampling shows substantial E.coli O157:H7 decline in 2004[EB].2005[2006,9,7].http://www.fsis.usda.gov/news_&_events/NR_0228Q5_01 /index.asp.
[131]Roy S L,Lopez A S,Schantz P M.Trichinellosis surveillance—United States,1997-2001 [DB].MMWR Surveilliance Summary,2003,52:1-8.
[132]Pyburn D G,Gamble H R,Wagstrom E A,et al.Trichinae certification in the United States pork industry[J].Veterinary Parasitology,2005,132(1-2):179-183.
[133]Jordan D,McEwen S A,Lammerding A M,et al.Pre-slaughter control of Escherichia coli O157 in beef cattle:A simulation study[J].Preventive Veterinary Medicine,1999,41(1):55-74.
[134]Jordan D,McEwen S A,Lammerding A M,et al.A simulation model for studying the role of pre-slaughter factors on the exposure of beef carcasses to human microbial hazards[J].Preventive Veterinary Medicine,1999,41(1):37-54.
[135]Zhao S,McDermott P F,Friedman S,et al.Antimicrobial resistance and genetic relatedness among Salmonella from retail foods of animal origin:NARMS retail meat surveillance[J].Foodborne Pathogen Disease,2006,3(1):106-117.
[136]Sanderson M W,Sargeant J M,Renter D G,et al.Factors associated with the presence of coliforms in the feed and water of feedlot cattle[J].Applied and Environmental Microbiology,2005,71(10):6026-6032.
[137]Davis M A,Hancock D D,Rice D H.et al.Feedstuffs as a vehicle of cattle exposure to Escherichia coli O157:H7 and Salmonella enterica[S].Veterinary Microbiology,2003,95(3):199-210.
[138]LeJeune J T,Hancock D,Wasteson Y,et al.Comparison of E.coli O157 and Shiga toxin-encoding genes (stx) prevalence between Ohio,USA and Norwegian dairy cattle[J].International Journal of Food Microbiology,2006,109(1-2):19-24.
[139]Boqvist S,Hansson 1,Nord Bjerselius U,et al.Salmonella isolated from animals and feed production in Sweden between 1993 and 1997[J].Acta veterinaria Scandinavica,2003,44(3-4):181-197.
[140]Smith D,Blackford M,Younts S,et al.Ecological relationships between the prevalence of cattle shedding Escherichia coli O157:H7 and characteristics of the cattle or conditions of the feedlot pen[J].Journal of Food Protection,2001,64(12):1899-1903.
[141]Garber L,Wells S,Schroeder-Tucker L,et al.Factors associated with fecal shedding of verotoxin-producing Escherichia coli O157 on dairy farms[J].Journal of Food Protection,1999,62(4):307-312.
[142]Loneragan G H,Brashears M M.Effects of using retention-pond water for dust abatement on performance of feedlot steers and carriage of Escherichia coli O157 and Salmonella spp[J].Journal of the American Veterinary Medical Association,2005.226(8):1378-1383.
[143]Morrow J L.Mitloehner F M,Johnson A K,et al.Effect of water sprinkling on incidence of zoonotic pathogens in feedlot cattle[J].Journal of Animal Science,2005,83(8):1959-1966.
[144]Wilson S C,Morrow-Tesch J,Straus D C,et al.Airborne microbial flora in a cattle feedlot[J].Applied and Environmental Microbiology,2002,68(7):3238-3242.
[145]Zucker B A,Trojan S,Muller W.Airborne gram-negative bacterial flora in animal houses[J].Journal of Veterinary Medicine B,Infectious Diseases and Veterinary Public Health,2000,47:37-46.
[146]Lejeune J T,Kauffman M D.Effect of sand and sawdust bedding materials on the fecal prevalence of Escherichia coli O157:H7 in dairy cows[J].Applied and Environmental Microbiology,2005.71(1):326-330.
[147]Hegde N V,Cook M L,Wolfgang D R,et al.Dissemination of Salmonella enterica subsp.enterica Serovar Typhimurium var.Copenhagen clonal types through a contract heifer-raising operation[J].Journal of Clinical Microbiology,2005,43(8):4208-4211.
[148]Dodson K,LeJeune J.Escherichia coli O157:H7,Campylobacter jejuni,and Salmonella prevalence in cull dairy cows marketed in northeastern Ohio[J].Journal of Food Protection,2005,68(5):927-931.
[149]Vidovic S,Korber D R.Prevalence of Escherichia coli O157 in Saskatchewan cattle:Characterization of isolates by using random amplified polymorphic DNA PCR,antibiotic resistance profiles,and pathogenicity determinants[J].Applied and Environmental Microbiology,2006,72(6):4347-4355.
[150]Daniels M J,Hutchings M R,Greig A.The risk of disease transmission to livestock posed by contamination of farm stored feed by wildlife excreta[J].Epidemiology and Infection.2003.130(3):561-568.
[151]Wetzel A N,LeJeune J T.Clonal dissemination of Escherichia coli O157:H7 subtypes among dairy farms in northeast Ohio[J].Applied and Environmental Microbiology,2006,72(4):2621-2626.
[152]Fuller R.Probiotics in man and animals[J].Journal of Applied Bacteriology,1989,66(5):365-378.
[153]Garber L P,Wells S J,Hancock D D,et al.Risk factors for fecal shedding of Escherichia coli O157:H7 in dairy calves[J].Journal of the American Veterinary Medical Association,1995.207(1):46-49.
[154]Dargatz D,Wells L,Hancock D,et al.Factors associated with the presence of Escherichia coli O157 in the feces of feedlot cattle[J].Journal of Food Protection,1997,60(5):466-470.
[155]Sargeant J M,Sanderson M W,Griffin D D,et al.Factors associated with the presence of Escherichia coli O157 in feedlot-cattle water and feed in the Midwestern USA[J].Preventive Veterinary Medicine,2004,66(1-4):207-237.
[156]Herriott D E,Hancock D D,Ebel E D,et al.Association of herd management factors with colonization of dairy cattle by Shiga toxin-positive Escherichia coli O157[J].Journal of Food Protection,1998,61(7):802-807.
[157]Berg J,McAllister T,Bach S,et al.Escherichia coli O157:H7 excretion by commercial feedlot cattle fed either barley-or corn-based finishing diets[J].Journal of Food Protetion,2004,67(4):666-671.
[158]Diez-Gonzalez F,Callaway T,Kizoulis M,et al.Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle[J].Science,1998,281(5383):1666-1668.
[159]Schrezenmeir J,de Vrese M.Probiotics,prebiotics,and synbiotics—Approaching a defmition[J].The American Journal of Clinical Nutrition.2001,73(suppl):361S-364S.
[160]Nocek J E,Kautz W P.Direct-fed microbial supplementation on ruminal digestion,health,and performance of pre-and postpartum dairy cattle.Journal of Dairy Science,2006,89(1):260-266.
[161]Tournut J.Applications of probiotics to animal husbandry[J].Revue Scientifique et Technique de l'OIE (France),1989,8 (2):551-566.
[162]Brashears M M,Galyean M L,Loneragan G H,et al.Prevalence of Escherichia coli O157:H7 and performance by beef feedlot cattle given Lactobacillus direct-fed microbials[J].Journal of Food Protection,2003,66(5):748-754.
[163]Younts-Dahl S M,Osborn G D,Galyean M L,et al.Reduction of Escherichia coli O157 in finishing beef cattle by various doses of Lactobacillus acidophilus in direct-fed microbials[J].Journal of Food Protection,2005,68(1):6-10.
[164]Elam N A,Gleghorn J F,Rivera J D,et al.Effects of live cultures of Lactobacillus acidophilus (strains NP45 and NP51) and Propionibacterium freudenreichii on performance,carcass,and intestinal characteristics,and Escherichia coli strain O157 shedding of finishing beef steers[J].Journal of Animal Science,2003,81(11):2686-2698.
[165]Zhao T,Doyle M P,Harmon B G.Reduction of carriage of enterohemorrhagic Escherichia coli O157:H7 in cattle by inoculation with probiotic bacteria[J].Journal of Clinical Microbiology,1998,36(3):641-647.
[166]Zhao T,Tkalcic S,Doyle M P,et al.Pathogenicity of enterohemorrhagic Escherichia coli in neonatal calves and evaluation of fecal shedding by treatment with probiotic Escherichia coil[J].Journal of Food Protection,2003,66(6):924-930.
[167]Tkaicic S,Brown C A,Harmon B G,et al.Effects of diet on tureen proliferation and fecal shedding of Escherichia coil O157:H7 in calves[J].Journal of Food Protection,2000,63(12):1630-1636.
[168]Duncan S H,Doherty C J,Govan J R,et al.Characteristics of sheep-rumen isolates of Pseudomonas aeruginosa inhibitory to the growth of Escherichia coli O157[J].FEMS Microbiology Letters,1999,180(2):305-310.
[169]Duncan S H,Booth I R,Flint H J,et al.The potential for the control of Escherichia coli O157 in farm animals[J].Symposium series(Society for Applied Microbiology),2000,29(Suppl):157S-165S.
[170]Takahashi M,Taguchi H,Yamaguchi H,et al.Therapeutic and preventative effect of probiotic bacterium Clostridium butyricium on Enterohaemorrhagic Escheriehia coil O157:H7 infection[C].2000 4th International Symposium and Workshop on "Shiga Toxin(Verotoxin)-producing Escherichia coil Infections." FT"EC 2000Kyoto,Japan.(VTEC 2000,C/o The Convention:Minami-Aoyama,Minato-ku,Tokyo),2000.
[171]Callaway T R,Anderson R C,Edrington T S,et al.What are we doing about Escherichia coil O157:H7 in cattle[J].Journal of Animal Science,2004,82(E-Suppl):E93-99.
[172]de Vaux A,Morrison M,Hutkins R W.Displacement of Escherichia coli O157:H7 from rumen medium containing prebiotic sugars.Applied and Environmental Microbiology,2002,68(2):519-524.
[173]Braden K W,Blanton J R Jr,Allen V G,et al.Ascophyllum nodosum supplementation:a preharvest intervention for reducing Escherichia coil O157:H7 and Salmonella spp.in feedlot steers[J].Journal of Food Protection,2004,67(9):1824-1828.
[174]Bosilevac J M,Nou X,Osborn M S,et al.Development and evaluation of an on-line hide decontamination procedure for use in a commercial beef processing plant[J].Journal of Food Protection,2005,68(2):265-272.
[175]Bosilevac J M,Shackeiford S D,Brichta D M,et al.Efficacy of ozonated and electrolyzed oxidative waters to decontaminate hides of cattle before slaughter[J].Journal of Food Protection,2005,68(7):1393-1398.
[176]Elder R,Keen J,Wittum T,et al.Intervention to reduce fecal shedding of enterohemorrhagic Escherichia coil O157:H7 in naturally infected cattle using neomycin sulphate[C].American Society of Animal Science/American Dairy Science Association,Joint Meeting.Quebec:602,2002.
[177]Woerner D,Ransom J,Sofos J N,et ai.Preharvest processes for microbial control in cattle[J].Food Protection Trends,2006,26:393-400.
[178]Russell J B,Strobel H J.Effect of ionophores on ruminal fermentation[J].Applied and Environmental Microbiology,1989,55(1):1-6.
[179]Russell J B,Houlihan A J.lonophore resistance of ruminal bacteria and its potential impact on human health[J].FEMS Microbiology Review,2003,27(1):65-74.
[180]Callaway T R,Adams K A,Russell J B.The ability of "low g+c gram-positive" ruminal bacteria to resist monensin and counteract potassium depletion[J].Current Microbiology,1999,39(4):226-230.
[181]Callaway T R,Russell J B.Variations in the ability of ruminal gram-negative Prevotella species to resist monensin[J].Current Microbiology,2000,40(1):185-189.
[182]Edrington T S,Callaway T R,Varey P D,et al.Effects of the antibiotic ionophores monensin,lasalocid,laidlomycin propionate and bambermycin on Salmonella and E.coli O157:H7 in vitro[J].Journal of Applied Microbiology,2003,94(2):207-213.
[183]Edrington T S,Callaway T R,Bischoff K M,et al.Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E.coli O157:H7 and Salmonella typhimurium[J].Journal of Animal Science,2003,81(2):553-560.
[184]Lefebvre B,Malouin F,Roy G,et al.Growth performance and shedding of some pathogenic bacteria in feedlot cattle treated with different growth-promoting agents[J].Journal of Food Protection.2006.69(6):1256-1264.
[185]Judge N A,Mason H S,O'Brien A D.Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces[J].Infection and Immunity.2004,72(1):168-175.
[186]Potter A A,Klashinsky S,Li Y,et al.Decreased shedding of Escherichia coli O157:H7 by cattle following vaccination with type Ⅲ secreted proteins[J].Vaccine,2004,22(3-4):362-369.
[187]Peterson R E,Smith D R,Moxley R A,et al.Vaccination for Escherichia coli O157:H7 in Market Ready Feedlot Cattle[R],pp.61-63.Nebraska Beef Report,University of Nebraska,Lincoln,2005.
[188]Van Donkersgoed J,Hancock D,Rogan D,et al.Escherichia coli O157:H7 vaccine field trial in 9 feedlots in Alberta and Saskatchewan[J].The Canadian Veterinary Journal,2005,46(8):724-728.
[189]Conlan J W,KuoLee R,Webb A,et al.Salmonella landau as a live vaccine against Escherichia coli O157:H7 investigated in a mouse model of intestinal colonization[J].Canadian Journal of Microbiology,1999,45(4):723-731.
[190]Conlan J W,KuoLee R,Webb A,et al.Oral immunization of mice with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 admixed with cholera toxin fails to elicit protection against subsequent colonization by the pathogen[J].Canadian Journal of Microbiology.2000,46(3):283-290.
[191]Dziva F,Vlisidou I,Crepin V F,et al.Vaccination of calves with EspA,a key colonisation factor of Escherichia coli O157:H7,induces antigen-specific humoral responses but does not confer protection against intestinal colonisation[J].Veterinary Microbiology,2007,123(1-3):254-261.
[192]van Diemen P M,Dziva F,bu-Median A,et al.Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or 026:H-[J].Veterinary Immunology and Immunopathology,2007,116(1-2):47-58.
[193]Stewart V J.Nitrate respiration in relation to facultative metabolism in enterobacteria[J].Microbiological Review,1988,52(2):190-232.
[194]Callaway T R,Anderson R C,Genovese K J,et al.Sodium chlorate supplementation reduces E.coli O157:H7 populations in cattle[J].Journal of Animal Science,2002,80(6):1683-1689.
[195]Callaway T R,Edrington T S,Anderson R C,et al.Escherichia coli O157:H7 populations in sheep can be reduced by chlorate supplementation^].Journal Food of Protection,2003,66(2):194-199.
[196]Hankin E H.faction bactericide des eaux de la Jumma et du Gange sur le vibrion du cholera[J].Annales de lolnstitut Pateur Micobiologie,1896,10:511.
[197]Samsygina G A,Boni E G.Bacteriophages and phage therapy in pediatric practice[J].Pediatric 1984,4:67-70.
[198]Van Helvoort T.Bacteriological and physiological research styles in the early controversy on the nature of the bacteriophage phenomenon[J].Medical History,1992,3(3):24 3-270.
[199]Adams M H.Bacteriophages[J].Interscience,New York.OCLC 326505,1959.
[200]Summers W C.Felix d'Herelle and the origins of molecular biology[M].Yale University Press,New Haven,Conn.,1999.
[201]d'H(?)relle,F.Sur un microbe invisible antagonize des bacilles dysenteriques[J].Comptes Rendus de l'Acad(?)mie des Sciences (Paris),1917,165:373-375
[202]d' H(?)relle,F.The bacteriophage[J].Science News,1949,14:44-59.
[203]Ackermann,H W.Classification of Bacteriophages,pp.8-16.In R.Calendar (ed.) The Bacteriophages[M].Oxford University Press,New York,2006.
[204]ICTVdB Management 02.043.Myoviridae[DB].In:ICTVdB-The Universal Virus Database,version 4.Büchen-Osmond,C.(Ed),Columbia University,New York,USA,2006
[205]Chibani-Chennoufi S,Bruttin A,Dillmann M L,et al.Phage-host Interaction:an ecological perspective[J].Journal of Bacteriology,2004,186(12):3677-3686.
[206]Kutter E,Gachechiladze A,Poglazov E,et al.Evolution of T4-related phages[J].Virus Genes,1995,11(2-3):285-297.
[207]Sulakvelidze A,Barrow P.Phage therapy in animals and agribusiness[M],pp.335-380.In Kutter E,Sulakvelidze A(eds.),Bacteriophages:Biology and Applications.CRC Press,Boca Raton,Fla,2005.
[208]Sulakvelidze A,Kutter E.Bacteriophage therapy in humans[M],pp.381-436.In Kutter E,Sulakvelidze A(eds.),Bacteriophages:biology and applications.CRC Press,Boca Raton,Fla,2005.
[209]Leiman P G,Kanamani S,Mesyanzhinov V V,et al.Structure and morphogenesis of bacteriophage T4[J].Cellular and Mocleculare life sciences,2003,60(11):2356-2370.
[210]Mosig G,Eiserling F.T4 and related phages:Structure and Development[M],pp.225-267.In Calendar R(ed.),The Bacteriophages.Oxford University Press,New York:,2006.
[211]Matsui T,Griniuvien(?) B,Goldberg E,et al.Isolation and characterization of a molecular chaperone,gp57A,of bacteriophage T4[J].Journal of Bacteriology,1997,179(6):1846-1851.
[212]Burda M R,Miller S.Folding of coliphage T4 short tail fiber in vitro:analysing the role of a bacteriophage-encoded chaperone[J].European Journal of Biochemistry,1999,265(2):771-778.
[213]King J,Mykolajewycz N.Bacteriophage T4 tail assembly:proteins of the sheath,core and baseplate[J].Journal of Molecular Biology,1973,75(2):339-358.
[214]Moody M F,Makowski L.X-ray diffraction study of tail-tubes from bacteriophage T2L[J].Journal of Molecular Biology,1981,150(2):217-244.
[215]DeRosier D J,Klug A.Reconstruction of three dimensional structures from electron micrographs[J].Nature,1968,217:130-134.
[216]Lepault J,Leonard K.Three-dimensional structure of unstained,frozen-hydrated extended tails of bacteriophage T4[J].Journal of Molecular Biology,1985,182(3):431-441.
[217]Coombs D H,Arisaka F.T4 tail structure and function[M],pp.259-281.In Karam J D(ed.),Bacteriophage T4.American Society for Microbiology,Washington,D.C.,1994.
[218]Cerritelli M E,Wall J S,Simon M N,et al.Stoichiometry and domainal organization of the long tail-fiber of bacteriophage T4:A hinged viral adhesion[J].Journal of Molecular Biology.1996.260(5):767-780.
[219]Beckendorf S K.Structure of the distal half of the bacteriophage T4 tail fiber[J].Journal of molecular biology,1973,73(1):37-53.
[220]Makhov A M,Trus B L,Conway J F,et al.The short tail-fiber of bacteriophage T4:molecular structure and a mechanism for its conformational transition[J].Virology.1993,194(1):117-127.
[221]Arisaka F.Assembly and infection process of bacteriophage T4[J].Chaos,2005.15(4):7502(1)-7502(7).
[222]Goldberg E,Grinius L,Letellier L.Recognition,attachment,and injection[M],pp.347-356.In Karam J D,Drake J W,Kreuzer K N,et al(eds.).Molecular Biology of Bacteriophage T4.American Society for Microbiology,Washington,D.C.,1994.
[223]Morita M,Fischer C R,Mizoguchi K,et al.Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coli O157:H7[J].FEMS Microbiology Letters,2002,216(2):243-248.
[224]Riede I.Receptor specificity of the short tail fibres (gp12) of T-even type Escherichia coli phages[J].Molecular and General Genetics,1987,206(1):110-115.
[225]Moody M F.Sheath of bacteriophage T4.Ⅲ.Contraction mechanism deduced from partially contracted sheaths[J].Journal of Molecular Biology,1973,80(4):613-635.
[226]Puck T T,Garen A,Cline J.The mechanism of virus attachment to host cells:1.The roles of ions in the primary reaction[J].The Journal of Experimental Medicine,1951,93(1):65-88.
[227]Guttman B,Raya R,Kutter E.Basic phage biology[M].In Kutter E and Sulakvelidze A(eds.).Bacteriophages:Biology and Applications.CRC Press,Boca Raton,Fla,2005.
[228]Kudva 1 T,Jelacic S,Tarr P I,et al.Biocontrol of Escherichia coli O157 with O157-specific bacteriophages[J].Applied and Environmental Microbiology,1999,65(9):3767-3773.
[229]Abedon S T,Herschel T D,Stopper D.Bacteriophage latent-period evolution as a response to resource availability[J].Applied and Environmental Microbiology,2001,67(9):4233-4241.
[230]Luria,S E,Darnell J E,Baltimore D,et al.General Virology[M].Wiley,New York,1978.
[231]Mosig G,Lin G W,Franklin J,et al.Functional relationships and structural determinants of two bacteriophage T4 lysozymes:A soluble (gene e) and a baseplate-associated (gene 5) protein[J].The New Biologist,1989,1 (2):171-179.
[232]Zoon K C,Habersat M,Scocca J J.Synthesis of envelope polypeptides by Haemophilus influenzae during development of competence for genetic transformation[J].Journal of Bacteriology.1976.127(1):545-554.
[233]Kutter E,Guttman B,Carlson K.The transition from host to phage metabolism after T4 infection[M],pp.343-346.In Karam J D(ed.).Molecular biology of bacteriophage T4.American Society for Microbiology,Washington,D.C,1994.
[234]Kutter E,White T,Kashlev M,et al.Effects on host genome structure and expression[M],pp.357-368.In Karam J D,Drake J W,Kreuzer K N,et al(eds.),Molecular biology of bacteriophage T4.ASM Press,Washington,D.C,1994.
[235]Streisinger G,Mukai F,Dreyer W J,et al.Mutations affecting the lysozyme of phage T4[J].Cold Spring Harbor symposia on quantitative biology,1961,26:25-30.
[236]Lu M-J,Henning U.Lysis protein T of bacteriophage T4[J].Molecular and General Genetics,1992,235(2-3):253-258.
[237]Fischetti V A.Bacteriophage lytic enzymes:novel anti-infectives[J].Trends in Microbiology,2005,13(10):491-496.
[238]Sulakvelidze A,Alavidze Z,Morris JG Jr.Bacteriophage therapy[J].Antimicrobial Agents and Chemotherapy,2001,45(3):649-659.
[239]Ho K.Bacteriophage therapy for bacterial infections.Rekindling a memory from the pre-antibiotics era[J].Perspectives in Biology and Medicine,2001(1),44:1-16.
[240]Bruynoghe R,Maisin J.Essais de therapeutique au moyen du bacteriophage[J].Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales,1921,85:1120-1121.
[241]Rice T B.Use of bacteriophage filtrates in treatment of suppurative conditions:report of 300 cases[J].The American Journal of Medical Science,1930,179(3):345-360.
[242]Schless R A.Staphylococcus aureus meningitis:treatment with specific bacteriophage[J].Archives of Pediatrics and Adolescent Medicine,1932,44:813-822.
[243]Stout B F.Bacteriophage therapy[J].Texas State Journal of Medicine,1933,29:205-209.
[244]Smith H W,Huggins M B.Effectiveness of phages in treating experimental Escherichia coli diarrhoea in calves,piglets and lambs[J].Journal of General Microbiology,1983,129(8):2659-2675.
[245]Smith H W,Huggins M B,Shaw K M.Factors influencing the survival and multiplication of bacteriophages in calves and in their environment[J].Journal of General Microbiology,1987.133(5):1127-1135.
[246]Smith H W,Huggins H B,Shaw K M.The control of experimental Escherichia coli diarrhoea in calves by means of bacteriophages[J].Journal of General Microbiology,1987,133(5):1111-1126.
[247]Barrow P,Lovell M,Berchieri A Jr.Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves[J].Clinical and Diagnostic Laboratory Immunity,1998,5(3):294-298.
[248]Lee N,Harris D L.The effect of bacteriophage treatment to reduce the rapid dissemination of Salmonella typhimurium in pigs[J].Proceedings of the American Association of Swine Veterinarians,2001,32:555-557.
[249]Huff W E,Huff G R,Rath N C,et al.Prevention of escherichia coli infection in broiler chickens with a bacteriophage aerosol spray[J].Poultry Science,2002,81(10):1486-1491.
[250]Huff W E,Huff G R,Rath N C,et al.Bacteriophage treatment of a severe Escherichia coli respiratory infection in broiler chickens[J].Avian Diseases,2003,47(4):1399-1405.
[251]Huff W E,Huff G R,Rath N C,et al.Evaluation of aerosol spray and intramuscular injection of bacteriophage to treat an Escherichia coli respiratory infection[J].Poultry Science.2003,82(7):1108-1112.
[252]Huff W E,Huff G R,Rath N C,et al.Evaluation of the influence of bacteriophage titer on the treatment of colibacillosis in broiler chickens[J].Poultry Science,2006,85(8):1373-1377.
[253]Loc Carrillo C,Atterbury R J,el-Shibiny A,et al.Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens[J].Applied and Environmental Microbiology,2005,71(11):6554-6563.
[254]Borie C,Albala 1,Sanchez P,et al.Bacteriophage treatment reduces Salmonella colonization of infected chickens[J].Avian Diseases,2008,52(1):64-67.
[255]Smith H W,Huggins M B.Successful treatment of experimental Escherichia coli infections in mice using phage:its general superiority over antibiotics[J].Journal of General Microbiology,1982,128(2):307-318.
[256]Bogovazova G G,Voroshilova N N,Bondarenko V M.The efficacy of Klebsiella pneumoniae bacteriophage in the therapy of experimental Klebsiella infection[J].Zhurnal mikrobiologii.epidemiologii,i immunobiologii,1991,4:5-8.
[257]Bogovazova G G,Voroshilova N N,Bondarenko V M,et al.lmmunobiological properties and therapeutic effectiveness of preparations from Klebsiella bacteriophages[J].Zhurnal mikrobiologii.epidemiologii,i immunobiologii,1992,3:30-33.
[258]Soothill J S,Lawrence J C,Ayliffe G A J.The efficacy of phages in the prevention of the destruction of pigskin in vitro by Pseudomonas aeruginosa[J].Medical Science Research,1988,16:1287-1288.
[259]Soothill J S.Treatment of experimental infections of mice with bacteriophage[J].Journal of Medical Microbiology,1992,37(4):258-261.
[260]Soothill J S.Bacteriophage prevents destruction of skin grafts by Pseudomonas aeruginosa[i].Burns.1994,20:209-211.
[261]Vijayashree R,Joe A F,Rial D R.Prevention of Clostridium difficile-induced ileocecitis with Bacteriophage[J].Anaerobe,1999,5(2):69-78.
[262]Cao J,Sun Y,Berglindh T,et al.Helicobacter pylori-antigen-binding fragments expressed on the filamentous M13 phage prevent bacterial growth[J].Biochimica et Biophysica Acta,2000,1474(1):107-113.
[263]Biswas B,Adhya S,Wshart P,et al.Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium[J].Infection and Immunity,2002.70(1):204-210.
[264]Cerveny K E,DePaola A,Duckworth D H,et al.Phage therapy of local and systemic disease caused by Vibrio vulnificus in iron-dextran-treated mice[J].Infection and Immunity,2002.70(11):6251-6262.
[265]Matsuzaki S.Yasuda M,Nishikawa H,et al.Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11[J].Journal of Infection Disease.2003,187(4):613-624.
[266]Wang J,Hu B,Xu M,et al.Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant Pseudomonas aeruginosa[J].International Journal of Molecular Medicine,2006,17(2):309-317.
[267]Wang J,Hu B,Xu M,et al.Therapeutic effectiveness of bacteriophages in the rescue of mice with extended spectrum beta-lactamase-producing Escherichia coli bacteremia[J].International Journal of Molecular Medicine,2006,17(2):347-355.
[268]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[269]Park S C,Shimamura I,Fuktmaga M,et al.Isolation of bacteriophages specific to a fish pathogen,Pseudomonas plecoglossicida,as a candidate for disease control[J].Applied and Environmental Microbiology,2000,66(4):1416-1422.
[270]Park S C,Nakai T.Bacteriophage control of Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis[J].Diseases of aquatic organisms,2003,53(1):33-39.
[271]Imbeault S,Parent S,Lagac(?) M,et al.Using bacteriophages to prevent furunculosis caused by Aeromonas salmonicida in farmed brook trout[J].Journal of Aquatic Animal Health,2006,18:203-214.
[272]Karunasagar I,Shivu M M,Girisha S K,et al.Biocontrol of pathogens in shrimp hatcheries using bacteriophages[J].Aquaculture,2007,268(1-4):288-292.
[273]Nakai T,Sugimoto R,Park K H,et al.Protective effects of bacteriophage on experimental Lactococcus garvieae infection in yellowtail[J].Diseases of aquatic organisms,1999,37(1):33-41.
[274]Jones J B,Jackson L E,Balogh B,et al.Bacteriophages for plant disease control[J].Annual Review of Phytopathoiogy,2007,45:245-262.
[275]Moore E S.d'H(?)relle's bacteriophage in relation to plant parasites[J].South African Journal of Science,1926,23:306.
[276]Momol T,Jones J,Olson S,et al.Integrated management of bacterial spot on tomato in Florida[EB].Rep.PP110,EDIS,Institute of Food Agricultural Science,University of Florida,2002.
[277]Freitag T,Squires R A,Schmid,J.Naturally occurring bacteriophage iyse a largeproportion of canine and feline uropathogenic Escherichia coli isolates in vitro[J].Research in Veterinary Science,2008,85:1-7.
[278]Br(u|¨)ssow H.Phage therapy:the Escherichia coli experience[J].Microbiology,2005,151(7):2133-2140.
[279]Ronner A B,Cliver D O.Isolation and characterization of a coliphage specific for Escherichia coil O157:H7[J].Journal of Food Protection,1990,53:944-947.
[280]杜崇涛,王文东,刘军等.肠出血性大肠杆菌O157:H7噬菌体的分离纯化[J].吉林畜牧兽医.2008,241(29):6-8.
[281]M izoguchi K,Morita M,Fischer C R,et al.Coevolution of bacteriophage PP01 and Escherichia coli O157:H7 in continuous culture[J].Applied and Environmental Microbiology,2003,69(1):170-176.
[282]Tanji Y,Shimada T,Yoiehi M,el al.Toward rational control of Escherichia coli O157:H7 by a phage cocktail[J].Applied Microbiology and Biotechnology,2004,64:270-274.
[283]Fischer C R,Yoichi M,Unno H,et al.The coexistence of Escherichia coli serotype O157:H7 and its specific bacteriophage in continuous culture[J].FEMS Microbiology Letters,2004,241(2):171-177.
[284]Waddell T,Mazzocco,A,Johnson R,et al.Control of Escherichia coli O157:H7 infection of calves by bacteriophages[C].4th International Symposium and Workshop on Shiga toxin (verocytotoxin)-producing Escherichia coli (VTEC 2000) Kyoto,Japan,2000.
[285]Sheng,H,Knecht H J,Kudva I T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72(8):5359-5366.
[286]Bach S J,McAllister T A,Veira D M,et al.Effect of bacteriophage DC22 on Escherichi coli O157:H7 in an artificial rumen system (Rusitec) and inoculated sheep[J].Animal Research,2003,52(2):89-101.
[287]Raya R R,Varey P,Oot R A,et al.Isolation and characterization of a new T-even bacteriophage,CEV1,and determination of its potential to reduce Escherichi coli O157:H7 levels in sheep[J].Applied and Environmental Microbiology,2006,72(9):6405-6410.
[288]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogen Disease,2008,5(2):183-191.
[289]Tanji Y,Shimada T,Fukudomi H,et al.Therapeutic Use of Phage Cocktail for Controlling Escherichia coli O157:H7 in Gastrointestinal Tract of Mice[J].Journal of bioscience and bioengineering,2005,100(3):280-287.
[290]Capparelli R,Ventimiglia I,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infect Diseases,2005,12(3):248-53.
[291]O'Flynn G,Ross R P,Fitzgerald G F,et al.Evaluation of a cocktail of three bacteriophages for biocontrol of Escherichia coli O157:H7[J].Applied Microbiology and Biotechnology,2004,70(6):3417-3424.
[292]Sharma M,Ryu J H,Beuchat L R.Inactivation of Escherichia coli O157:H7 in biofilm on stainless steel by treatment with an alkaline cleaner and a bacteriophage[J].Journal of Applied Microbiology,2005,99(3):449-459.
[293]Abuladze T,Li M,Menetrez M Y,et al.Bacteriophages reduce experimental contamination of hard surfaces,tomato,spinach,broccoli,and ground beef by Escherichia coli O157:H7[J].Applied and Environmental Microbiology,2008,74(20):6230-6238.
[294]Carlton R M,Noordman W H,Biswas B,et al.Bacteriophage P100 for control of Listeria monocytogenes in foods:Genome sequence,bioinformatic analyses,oral toxicity study,and application[J].Regulatory Toxicology and Pharmacology,2005,43(3):301-312.
[295]Embleton M L,Nair S P,Heywood W,et al.Development of a novel targeting system for lethal photosensitization of antibiotic-resistant strains of Staphylococcus aureus[J].Antimicrobial Agents and Chemotherapy,2005,49(9):3690-3696.
[296]Yacoby 1,Shamis M,Bar H,et al.Targeting antibacterial agents by using drug-carrying filamentous bacteriophages[J].Antimicrobial Agents and Chemotherapy,2006,50(6):2087-2097.
[297]Westwater C,Kasman L M,Schofield D A,et al.Use of genetically engineered phage to deliver antimicrobial agents to bacteria:an alternative therapy for treatment of bacterial infections[.l].Antimicrobial Agents and Chemotherapy,2003,47(4):1301-1307.
[298]Hagens S,Hebal A,von Ahsen U,et al.Therapy of experimental pseudomonas infections with a nonreplicating genetically modified phage[J].Antimicrobial Agents and Chemotherapy,2004,48(10):3817-3822.
[299]Larocca D,Brug M A,Jensen-pergakes K,et al.Evolving phage vectors for cell targeted gene delivery[J].Current Pharmaceutical Biotechnology,2002,3(1):45-57.
[300]Jado I,L(?)pez R,Carcia E,et al.Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model[J].Journal of Antimicrobial Chemotherapy,2003,52(6):967-973.
[301]O'Flaherty S,Coffey A,Meaney W,et al.The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci,including methicillin-resistant Staphylococcus aureus[J].Journal of Bacteriology,2005,187(20):7161—7164.
[302]Kutter E,Sulakvelidze A.Editors,Bacteriophages:Biology and Applications[M],CRC Press.2005.
[303]Panthel K,Jechlinger W,Matis A,et al.Generation of Helicobacter pylori ghosts by PhiX protein E-mediated inactivation and their evaluation as vaccine candidates[J].Infecttion and Immunity,2003,71(1):109-116.
[304]Ebensen T,Paukner S,Link,C,et al.Bacterial ghosts are an efficient delivery system for DNA vaccines[J].The Journal of Immunology,2004,172(11):6858-6865.
[305]Paukner S,Stidl T,Kudela P,et al.Bacterial ghosts as a novel advanced targeting system for drug and DNA delivery[J].Expert Opinion on Drug Delivery,2006,3(1):11-22.
[306]Skumik M,Strauch E.Phage therapy:facts and fiction[J].International Journal of Medical Microbiology,2006,296(1):5-14.
[307]Goodridge L D.Bacteriophage biocontrol of plant pathogens:fact or fiction[J].Trends in Biotechnology,2004,22(8):384-385.
[308]Petty N K,Evans T J,Fineran P C,et al.Biotechnological exploitation of bacteriophage research[J].Trends Biotechnology.2007,25(1):7-15.
[1]Cobboid R N,Hancock D D,Rice D H,et al.Rectoanal junction colonization of feedlot cattle by Escherichia coli O157:H7 and its association with supershedders and excretion dynamics[J].Applied and Environmental Microbiology,2007,73(5):1563-1568.
[2]Loneragan G H,Brashears M M.Pre-harvest interventions to reduce carriage of E.coli O157 by harvest-ready feedlot cattle[J].Meat Science,2005,71(1):72-78.
[3]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[4]Rice D H,Sheng H Q,Wynia S A,et al.Rectoanal mucosal swab culture is more sensitive than fecal culture and distinguishes Escherichia coli O157:H7-colonized eattle and those transiently shedding the same organism[J].Journal of Clinical Microbiology,2003,41(11):4924-4929.
[5]Greenquist M A,Drouillard J S,Sargeant J M,et al.Comparison of rectoanal mucosal swab cultures and fecal cultures for determining prevalence of Escherichia coli O157:H7 in feediot cattle[J].Applied and Environmental Microbiology,2005,71(10):6431-6433.
[6]Omisakin F,MacRae M,Ogden I D,et al.Concentration and prevalence of Escherichia coil O157 in cattle faeces at slaughter[J].Applied and Environmental Microbiology,2003,69(5):2444-2447.
[7]Bach,S J,Selinger L J,Stanford K,et al.Effect of supplementing corn- or barley-based feedlot diets with canola oil on faecal shedding of Escherichia coli O157:H7 by steers[J].Journal of Applied Microbiology,2005,98(2):464-475.
[8]Chase-Topping M E,McKendrick I J,Pearce M C,et al.Risk factors for the presence of high-level shedders of Escherichia coli O157 on Scottish farms[J].Journal of Clinical Microbiology,2007,45(5):1594-1603.
[9]Chibani-Chennoufi S,Sidoti J,Buttin A,el al.In vitro and in vivo bacteriolytic activities of Escherichia coli phages:implications for phage therapy[J].Antimicrobial Agents and Chemotherapy,2004,8(7):2558-2569.
[10]Dabrowska K,Switala-Jelen K,Oposki A,et al.Bacterophage penetration in vertebrates[J].Journal of Applied Microbiology,2005,98(1):7-13.
[11]Capparelli R,Ventimiglia,I,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infection,2006,12(3):248-253.
[12]Sheng H,Knecht H J,Kudva I T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72(8):5359-5366.
[13]Echeverry A,Loneragan G H,Wagner B A,et al.Effect of intensity of feeai pat sampling on estimates of Escherichia coli O157 prevalence[J].American Journal of Veterinary Research,2005,66(12):2023-2027.
[14]Khaltsa M L,Bauer M L,Gibbs P S,et al.Comparison of two sampling methods for Escherichia coli O157:H7 detection in feedlot cattle[J].Journal of Food Protection,2005,68(8):1724-1728.
[15]Schamberger G P,Diez-Gonzalez F.Assessment of resistance to colicinogenic Escherichia coli by E.coli O157:H7 strains[J].Journal of Applied Microbiology,2005,98(1):245-252.
[16]Smith D,Blackford M,Younts S,et al.Ecological relationships between the prevalence of cattle shedding Escherichia coli O157:H7 and characteristics of the cattle or conditions of the feedlot pen[J].Journal of Food Protection,2001,64(12):1899-1903.
[17]Naylor,S W,Low J C,Besser T E,et al.Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host[J].Infection and Immunity,2003,71(3):1505-1512.
[18]Fox J T,Depenbusch B E,Drouillard J S,et al.Dry-rolled or steam-flaked grain-based diets and fecal shedding of Escherichia coli O157 in feedlot cattle[J].Journal of Animal Science,2007,85(5):1207-1212.
[19]Lim J Y,Li J,Sheng H,et al.Escherichia coli O157:H7 colonization at the rectoanal junction of long-duration culture-positive cattle[J].Applied and Environmental Microbiology,2007,73(4):1380-1382.
[20]Reinstein S,Fox J T,Shi X,et al.Prevalence of Escherichia coli O157:H7 in the American bison (Bison bison) [J].Journal of Food Protection,2007,70(11):2555-2560.
[21]McAllister T A,Bach S J,Stanford K,et al.Shedding of Escherichia coli O157:H7 by cattle fed diets containing monensin or tylosin[J].Journal of Food Protection,2006,69(9):2075-2083.
[22]Garc(?)a-S(?)nchez A,S(?)nchez S,Rubio R,et al.Presence of Shiga toxin-producing E.coli O157:H7 in a survey of wild artiodactyls[J].Veterinary Microbiology,2007,121(3-4):373-377.
[23]Davis M A,Rice D H,Sheng H,et al.Comparison of cultures from rectoanal-junction mucosal swabs and feces for detection of Escherichia coli O157 in dairy heifers[J].Applied and Environmental Microbiology,2006,72(5):3766-3770.
[24]Bach S J,McAllister T A,Veira D M,et al.Effect of bacteriophage DC22 on Esherichia coli O157:H7 in an artifical rumen system (Rusitec) and inoculated sheep[J].Animal Research,2003,52(2):89-101.
[25]Sambrook J,Russell D W.Molecular cloning:a laboratory manual-3~(rd) ed[M].Cold Spring Harbor Laboratory Press,Cold Spring Harbor,New York,2001.
[26]Khaitsa M L,Smith D R,J.Stoner A,et al.Incidence,duration,and prevalence of Escherichia coli O157:H7 fecal shedding by feedlot cattle during the feeding period[J].Journal of Food Protection,2003,66(11):1972-1977.
[27]SAS Institute,Inc.SAS user guide:statistics,version 9.1[CP].SAS Institute,Cary,N.C.Science Publishing Company,Inc.,New York,1999.
[28]Cray W C,Moon H W.Experimental infection of calves and adult cattle with Escherichia coli O157:H7[J].Applied and Environmental Microbiology,1995,61(4):1586-1590.
[29]Elder R O,Keen J E,Siragusa G R,et al.Correlation of Enterohaemorrhagic Escherichia coli O157 prevalence in feces and carcasses of beer cattle during progressing[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):2999-3003.
[30]Serna,A,Boedeker E C.Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections[J].Current Opinion in Gastroenterology,2008,24(1):38-47.
[31]Tarr P I.Escherichia coli O157:H7:clinical,diagnostic,and epidemiological aspects of human infection[J].Clinical Infectious Diseases,1995,20(1):1-8.
[32]Tauxe R V.Emerging foodborne diseases:an evolving public health challenge[J].Emerging Infectious Disease,1997,3(4):425-434.
[33]Besser T E,LeJeune J T,Rice D.et al.Prevention and control of Escherichia coli O157:H7[M],pp.167-174.In Torrence M E,Isaacson R E(eds.),Microbial Food Safety in Animal Agriculture Current Topics.Iowa State Press,Blackwell Publishing Company,Ames,1A,2003.
[34]Loneragan G H,Brashears M M.Pre-harvest interventions to reduce carriage of E.coli O157 by harvest-ready feedlot cattle[J].Meat Science,2005,71(1):72-78.
[35]Sargeant J M,Amezcua M R,Rajic A,et al.Pre-harvest interventions to reduce the shedding of E.coli O157 in the faeces of weaned domestic ruminants:a systematic review[J].Zoonoses and Public Health,2007,54(6-7):260-277.
[36]Ronner A B,Cliver D O.Isolation and characterization of a coliphage specific for Escherichia coli O157:H7[J].Journal of Food Protection,1990,53:944-947.
[37]Waddell T,Mazzocco A,Johnson R,et al.Control of Escherichia coli O157:H7 infection of calves by bacteriophages[C].4~(th) International Symposium and Workshop on Shiga toxin(verocytotoxin)-producing Escherichia coli (VTEC 2000) Kyoto,Japan,2000.
[38]Smith H W,Huggins M B.Effectiveness of phages in treating experimental Escherichia coli diarrhea in calves,piglets and lambs[J].Journal of General Microbiology,1983,129(8):2659-2675.
[39]Smith H W,Huggins M B,Shaw K M.Factors influencing the survival and multiplication of bacteriophages in calves and in their environment[J].Journal of General Microbiology,1987,133(5):1127-1135.
[40]Hoffmann,M.Animal experiments on the mucosal passage and absorption viremia of T3 phages after oral,tracheal and rectal administration.Zentralblatt fur Bakteriologie,Parasitenkunde,Infektionskrankheiten und Hygiene[C].1.Abt.Medizinisch-hygienische Bakteriologie,Virusforschung und Parasitologic Originale,1965,198(4):371-390.
[41]Brown,C A,Harmon B G,Zhao T,et al.Experimental Escherichia coli O157:H7 carriage in calves[J].Applied and Environmental Microbiology,1997,63(1):27-32.
[42]Grauke L J,Kudva I T,Yoon J W,et al.Gastrointestinal tract location of Escherichia coli O157:H7 in ruminants[J].Applied and Environmental Microbiology,2002,68(5):2269-2277.
[43]Laven R A,Ashmore A,Stewart C S.Escherichia coli in the rumen and colon of slaughter cattle,with particular reference to E.coli O157[J].Veterinary Journal,2003,165(1):78-83.
[44]Naylor S W,Low J C,Besser T E,et al.Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host[J].Infection and Immunity,2003,71(3):1505-1512.
[45]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[46]Dziva F,van Diemen P M,Stevens M P,et al.Identification of Escherichia coli O157:H7 genes influencing colonization of the bovine gastrointestinal tract using signature-tagged mutagenesis[J].Microbiology,2004,150(11)3631-3645.
[47]Sheng H,Lim J Y,Knecht H J,et al.Role of Escherichia coli O157:H7 virulence factors in colonization at the bovine terminal rectal mucosa[J].Infection and Immunity,2006,74(8):4685-4693.
[48]Morita M,Fischer C R,Mizoguchi K,et al.Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coli O157:H7[J].FEMS Microbiology Letters,2002,216(2):243-248.
[49]Rozema E A,Stephens T P,Bach S J,et al.Oral and rectal administration of bacteriophages for control of Escherichia coli O157:H7 in feedlot cattle[J].Journal of Food Protection,2009,72(2):241-250.
[50]Tanji Y,Shimada T,Yoichi M,et al.Toward rational control of Escherichia coli O157:H7 by a phage cocktail[J].Applied Microbiology and Biotechnology,2004,64(2):270-274.
[51]Tanji Y,Shimada T,Fukudomi H,et al.Therapeutic use of phage cocktail for controlling Escherichia coli O157:H7 in gastrointestinal tract of mice[J].Journal of Bioscience and Bioengineering,2005,100(3):280-287.
[52]Payne R J H,Jansen V A A.Phage therapy:the peculiar kinetics of self-replicating pharmaceuticals [J].Clinical pharmacology & therapeutics,2000,68(3):225-230.
[53]Calendar R.The bacteriophages,vol.1[M].Plenum Press,New York,1998.
[54]Vijayashree R,Fralick J A,Rolfe R D.Prevention of Clostridium difficile-induced ileocecitis with bacteriophage[J].Anaerobe,1999,5(2):69-78.
[55]Wiggins B A,Alexander M.Minimum bacterial density for bacteriophage replication:implications for significance of bacteriophages in natural ecosystems[J].Applied and Environmental Microbiology,1985,49(1):19-23.
[56]Chibani-Chennoufi S,Bruttin A,Dillmann M L,et al.Phage-host Interaction:an ecological perspective[J].Journal of Bacteriology,2004,186(12):3677-3686.
[57]Poulsen L K,Lan F,Kristensen C S,et al.Spatial distribution of Escherichia coli in the mouse large intestine inferred from rRNA in situ hybridization[J].Infection and Immunity,1994.62(11):5191-5194.
[58]Vanselow B A,Krause D O,McSweeney C S.The Shiga toxin-producing Escherichia coli,their ruminant hosts,and potential on-farm interventions:a review[J].Australian Journal of Agriculture Research,2005,56(3):219-214.
[59]Shere J A,Bartlett K J,Kaspar C W.Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1998,64(4):1390-1399.
[60]Stanford K,Bach S J,Marx T H,et al.Monitoring Escherichia coli O157:H7 in inoculated and naturally colonized feedlot cattle and their environment[J].Journal of Food Protection,2005,68(1):26-33.
[61]Jordan K N,Maher M M.Sensitive detection of Escherichia coli O157:H7 by conventional plating techniques[J].Journal of Food Protection,2006,69(3):689-692.
[62]Sanderson M W,Gay J M,Hancock D D,et al.Sensitivity of bacterioiogic culture for detection of Escherichia coli O157:H7 in bovine feces[J].Journal of Clinical Microbiology,1995,33(10):2616-2619.
[63]Sanderson M W,Sargeant J M,Nagaraja T G.Effect of pooling bovine fecal samples on the sensitivity of detection of Escherichia coli O157:H7[J].Veterinary Microbiology,2005,110(1-2):125-130.
[64]Irwin K E,Smith D R,Gray T J,et al.Behavior of cattle towards devices to detect food-safety pathogens in feedlot pens[J].Bovine Practice,2002,36:5-9.
[65]Smith D R,Gray J T,Moxiey R A,et al.A diagnostic strategy to determine the Shiga toxin-producing Escherichia coli O157 status of pens of feedlot cattle[J].Epidemiology and Infection,2004,132(2):297-302.
[66]Muller E E,Grabow WOK,Ehlers M M.Immunomagnetic separation ofEscherichia coli Q157:H7 from environmental and wastewater in South Africa[J].Water SA,2003,29:427-432.
[67]Tortorello M L,Reineke K F,Stewart D S,et al.Comparison of methods for determining the presence of Escherichia coli O157:H7 in apple juice[J].Journal ofFood Protection,1998,61(11):1425-1430.
[68]Tutenel A V,Pierard D,Vandekerchove D et al.Sensitivity of methods for the isolation of Escherichia coli O157 from naturally infected bovine faeces[J].Veterinary Microbiology,2003,94(4):341-346.
[69]Wright D J,Chapman P A,Siddons C A.Immunomagnetic separation as a sensitive method for isolating Escherichia-coli O157 from food samples[J].Epidemiology and Infection,1994,113(1):31-39.
[70]Robinson S E,Wright E J,Hart C A,et al.Intermittent and persistent shedding of Escherichia coli O157 in cohorts of naturally infected calves[J].Journal of Applied Microbiology,2004,97(5):1045-1053.
[1]Tarr P I,Gordon C A,Chandler W L.Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome[J].Lancet,2005,365(9464):1073-1086.
[2]Elder R O,Keen J E,Siragusa G R,et al.Correlation of enterohemorrhagic Escherichia coli O157 prevalence in feces,hides,and carcasses of beef cattle during processing[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):2999-3003.
[3]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[4]Rangel J M,Sparling P H,Crowe C,et al.Epidemiology of Escherichia coli O157:H7 outbreaks.United states,1982-2002[J].Emerging Infectious Diseases.2005,11(4):603-609.
[5]Spencer J L,Guan J.Public health implications related to spread of pathogens in manure from livestock and poultry operations[M].Methods in Molecular Biology (Clifton,N.J.),2004,268:503-515.
[6]Serna A,Boedeker E C.Pathogenesis and treatment of shiga toxin-producing Escherichia coli infections[J].Current Opinion in Gastroenterology,2008,24(1):38-47.
[7]Hussein H S,Bollinger L M.Prevalence of Shiga toxin-producing Escherichia coli in beef cattle[J].Journal of Food Protection,2005,68(10):2224-2241.
[8]Stanford K,Croy D,Bach S J,et al.Ecology of Escherichia coli O157:H7 in commercial dairies in Southern Alberta[J].Journal of Dairy Science,2005,88(12):4441-4451.
[9]Sanderson M W,Sargeant J M,Shi X,et al.Longitudinal emergence and distribution of Escherichia coli O157 genotypes in a beef feedlot[J].Applied and Environmental Microbiology,2006,72(12):7614-7619.
[10]Nastasijevic I,Mitrovic R,Buncic S.Occurrence of Escherichia coli O157 on hides of slaughtered cattle[J].Letters in Appied micrcobiology,2007,46(1):126-131.
[11]Oporto B,Esteban J 1,Aduriz G,et al.Escherichia coli O157:H7 and non-O157 shiga toxin-producing E.coli in healthy cattle,sheep and swine herds in northern Spain[J].Zoonoses and Public Health,2008,55(2):73-81.
[12]Sulakvelidze A,Alavidze Z,Morris J G Jr.Bacteriophage therapy[J].Antimicrobial Agents and Chemotherapy,2001,45(3):649-659.
[13]Merril C R,Scholl D,Adhya S.Phage therapy[M],pp.725-739.In Calendar R(ed.).The Bacteriophages.Oxford University Press,New York,2006.
[14]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[15]Brüssow H.Phage therapy:the Escherichia coli experience[J].Microbiology,2005,151(Pt 7):2133-2140.
[16]Jones J B,Jackson L E,Balogh B,et al.Bacteriophages for plant disease controI[J].Annual Review of Phytopathology,2007,45:245-262.
[17]Greer G G.Bacteriophage control of foodborne bacteria[J].Journal of Food Protection,2005.68(5):1102-1111.
[18]Capparelli R,Ventimiglia 1,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infection,2006,12(3):248-253.
[19]Sheng H,Knecht H J,Kudva 1 T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72(8):5359-5366.
[20]Raya R R,Varey P,Oot R A,et al.Isolation and characterization of a new T-Even bacteriophage,CEV1,and determination of its potential to reduce Escherichia coli O157:H7 levels in sheep[J].Applied and Environmental Microbiology,2006,72(9):6405-6410.
[21]Abuladze T,Li M,Menetrez M Y,et al.Bacteriophages reduce experimental contamination of hard surfaces,tomato,spinach,broccoli,and ground beef by Escherichia coli O157:H7[J].Applied and Environmental Microbiology,2008,74(20):6230-6238.
[22]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogens and Disease,2008,5(2):183-191.
[23]Niu Y D,Xu Y,McAllsiter,T A,et al.Comparison of fecal versus rectoanal mucosal swab sampling for detecting Escherichia coli O157:H7 in experimentally inoculated cattle used in assessing bacteriophage as a mitigation strategy[J].Journal of Food Protection,2008,71 (4):691-698.
[24]Viscardi M,Perugini G A,Auriemma C,et al.Isolation and characterisation of two novel coliphages with high potential to control antibiotic-resistant pathogenic Escherichia coli (EHEC and EPEC) [J].International Journal of Antimicrobial Agents,2008,31(2):152-157.
[25]Carlton R M.Phage therapy:Past history and future prospects[J].Archivum Immunologia et Therapiae Experimentalis (Warsz),1999,47(5):267-274.
[26]Skurnik M,Pajunen M,Kilkunen S[J].Biotechnological challenges of phage therapy.Biotechnology Letters,2007,29(7):995-1003.
[27]Sambrook J,Russell D W.Molecular cloning:a laboratory manual-3rd edition[M].Cold Spring Harbor Laboratory Press,Cold Spring Harbor,New York,2001.
[28]Gannon V P,D'Souza S,Graham T,et al.Specific identification of Escherichia coli O157:H7 using multiplex PCR assay[J].Advances in Experimental Medicine and Biology,1997,412:81-82.
[29]Ahmed R,Bopp C,Borczyk A,et al.Phage-typing scheme for Escherichia coli O157:H7[J].Journal of Infectious Diseases,1987,155(4):806-809.
[30]Khakhria R,Duck D,Lior H.Extended phage-typing scheme for Escherichia coli O157:H7[J].Epidemiology and Infection,1990,105(3):511-520.
[31]Bach,S J,Selinger L J,Stanford K,et al.Effect of supplementing corn-or barley-based feedlot diets with canola oil on faecal shedding of Escherichia coli O157:H7 by steers[J].Journal of Applied Microbiology,2005,98(2):464-475.
[32]SAS Institute,Inc.SAS user guide:statistics,version 9.1[CP].SAS Institute,Cary,N.C.Science Publishing Company.Inc..New York.1999.
[33]Frost J A,Smith H R,Willshaw G A,et al.Phage-typing of Vero-cytotoxin(VT) producing Escherichia coli O157 isolated in the United Kingdom[J].Epidemiology and Infection,1989.103(1):73-81.
[34]Waterbury J B,Valois F W.Resistance to co-occurring phages enables marine Synechococcus communities to coexist with cyanophages abundant in seawater[J].Applied and Environmental Microbiology,1993,59(10):3393-3399.
[35]Suttle C A,Chan A M.Marine cyanophages infecting oceanic and coastal strains of Synechococcus:abundance,morphology,cross-infectivity and growth characteristics[J].Marine Ecology Progress Series,1993,92(1-2):99-109.
[36]Wichels A,Biel S S,Gelderblom H R,et al.Bacteriophage diversity in the North Sea[J].Applied and Environmental Microbilogy,1998,64(11):4128-4133.
[37]Weinbauer M G.Ecology of prokaryotic viruses[J].FEMS Microbiology Reviews,2004,28(2):127-181.
[38]Heller K J,Bryniok D.O-antigen-dependent mutant of bacteriophage TS[J].Journal of Virology.1984,49(1):20-25.
[39]Kudva I T,Jelacic S,Tarr P I,et al.Biocontrol ofEscherichia coli O157 with O157-specific bacteriophages[J].Applied and Environmental Microbiology,1999,65(9):3767-3773.
[40]Sharma R S,Mishra V,Mohmmed A,et al.Phage specificity and lipopolysaccarides of stem-and root-nodulating bacteria(Azorhizobium caulinodans,Sinorhizobium spp.,and Rhizobium spp.) of Sesbania spp[J].Archives of Microbiology,2008,189(4):411-418.
[41]Inoue T,Matsuzaki S,Tanaka S.A 26-kDa outer membrane protein,OmpK,common to Vibrio species is the receptor for a broad-host-range vibriophage,KVP40[J].FEMS Microbiology Letters,1995,125(1):101-106.
[42]Inoue T,Matsuzaki S,Tanaka S.Cloning and sequence analysis of Vibrio parahaemolyticus ompK gene encoding a 26-kDa outer membrane protein,OmpK,that serves as receptor for a broad-host-range vibriophage,KVP40[J].FEMS Microbiology Letters,1995,134(2-3):245-249.
[43]Nimmich W,Schmidt G,Krailmann-Wenzel U.Two different Escherichia coli capsular polysaccharide depolymerases each associated with one of the eoliphage phi K5 and phi K20[J].FEMS Microbiology Letters,1991,82(2):137-141.
[44]Scholl D,Rogers S,Adhya S,et al.Bacteriophage K1-5 encodes two different tail fiber proteins,allowing it to infect and replicate on both K1 and K5 strains of Escherichia coli[J].Journal of Virology,2001,75(6):2509-2515.
[45]Perry M B,Maclean L,Griffith D W.Structure of the O-chain polysaccharide of the phenol-phase soluble lipopolysaecharide of Escherichia coli O157:H7[J].Biochemistry and Cell Biology,1986,64(1):21-28.
[46]Iguchi A,lyoda S,Watanabe H,et al.O side chain deficency enhances sensitivity of Escherichia coli to Shiga toxin 2-converting bacteriophages[J].Current Microbiology,2007.54(1):14-19.
[47]Ho T D,Waidor M K.Enterohemorrhagic Escherichia coli O157:H7 gai mutants are sensitive to bacteriophage P1 and defective in intestinal colonization[J].Infection and Immunity,2007,75(4):1661-1666.
[48]Merino S,Camprubi S,Tom(?)s J M.Identification of the cell surface receptor for bacteriophage 18 from Aeromonas hydrophila[J].Research in Microbiology,1990,141(2):173-180.
[49]Yokoto S,Hayashi T,Matsumoto H.Identification of the lipopolysaccharide core region as the receptor site for a cytotoxin converting phage,phi CTX,of Pseudomonas aeruginosa[J].Journal of Bacteriology,1994,176(17):5262-5269.
[50]Morita M,Fischer C R.Mizoguchi K,et al.Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coil O157:H7[J].FEMS Microbiology Letters.2002,216(2):243-248.
[51]Mutoh N,Furukawa H,Mizushima S.Role of lipopolysaccharide and outer membrane protein of Escherichia coil K-12 in the receptor activity for bacteriophage T4[J].Journal of Bacteriology,1978,136(2):693-699.
[52]Yu F,Yamada H,Mizushima S.Role of lipopolysaccharide in the receptor function for bacteriophage Tulb in Escherichia coil[J].Journal of Bacteriology,1981,148(2):712-715.
[53]Koebnik R.Structural and functional roles the surface-exposed loops of the B-barrel memebrane protein OmpA from Escherichia coli[J].Journal of Bacteriology,1999,181(12):3688-3694.
[54]Power M L,Ferrari B C,Littlefield-Wyer J,et al.A naturally occurring novel allele of Escherichia coli Outer membrane protein A reduces sensitivity to bacteriophage[J].Applied and Environmental Microbiology,2006,72(12):7930-7932.
[55]Heller K J.Molecular interaction between bacteriophage and the gram-negative cell envelop[J].Archives of Microbiology,1992,158(30):235-248.
[56]Adams M H.Bacteriophages[M].Interscience,New York.OCLC 326505,1959.
[57]Arisaka F.Assembly and infection process of bacteriophage T4[J].Chaos,2005,15(4):7502(1)-7502(7).
[58]Williams Smith H,Huggins H B.Successful treatment of experimental Escherichia coli in mice using phages:its general superiority over antibiotics[J].Journal of General Microbiology,1982,128(2),307-318.
[59]Hagens S,Habel A,von Ahsen U,et al.Therapy of experimental Pseudomonas infections with a nonreplicating genetically modified phage[J].Anitmicrobial Agents and Chemotherapy,2004,48(10):3817-3822.
[60]Watanabe R,Mastsumoto T,Sano G,et al.Efficacy of bacteriophage therapy against gut-derived sepsis caused by Pseudomonas aeruginosa in mice[J].Antimicrobial Agents and Chemotherapy 2007,51(2):446-452.
[61]Matsuzaki S,Yasuda M,Nishikawa H,et al.Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11[J].Journal of Infection Disease.2003,187(4):613-624.
[62]Capparelli R,Parlato M,Bordello G,et al.Experimental phage therapy against Staphylococcus aureus in mice[J].Anitmicrobial Agents and Chemotherapy 2007,51(8):2765-2773.
[63]Biswas B,Adhya S,Washart P,et al.Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium[J].Infection and Immunity,2002,70(1):204-210.
[64]Carlton R M,Noordman W H,Biswas B,et al.Bacteriophage P100 for control of Listeria monocytogenes in foods:Genome sequence,bioinformatic analyses,oral toxicity study,and application[J].Regulatory Toxicology and Pharmacology,2005,43(3):301-312.
[65]Tanji Y,Shimada T,Fukudomi H,et al.Therapeutic use of phage cocktail for controlling Escherichia coli O157:H7 in gastrointestinal tract of mice[J].Journal of Bioscience and Bioengineering,2005,100(3):280-287.
[66]Yoichi M,Morita M,Mizoguchi K,et al.The criterion for selecting effective phage for Escherichia coli O157:H7 control[J].Biochemical Engineering Journal,2004,19(3):221-227.
[67]Mizoguchi K,Morita M,Fischer C R,et al.Coevolution of bacteriophage PP01 and Escherichia coli O157:H7 in continuous culture[J].Applied and Environmental Microbiology,2003,69(1):170-176.
[68]Park S C,Shimamura 1,Fukunaga M,et al.Isolation of bacteriophages specific to a fish pathogen,Pseudomonas plecoglossicida,as a candidate for disease control[J].Applied and Environmental Microbiology,2000,66(4):1416-1422.
[69]Santander J,Rogeson J.Phage-resistance of Salmonella enterica serovar Enteritidis and pathogenesis in Caenorhabditis elegans is mediated by the lipopolysaccharide[J].Electronic Journal of Biotechnology,2007,10(4):627-632.
[70]Ebert D.Experimental evolution of parasites[J].Science,1998,282(5393):!432-1436.
[71]Mora A,Leon S L,Blanco M,et al.Phage types,virulence genes and PFGE profiles of Shiga toxin-producing Escherichia coli O157:H7 isolated from raw beef,soft cheese and vegetables in Lima (Peru) [J].International Journal of Food Microbiology,2007,114(2):204-210.
[72]Ahmed R,Ali A,Demczuk W,et al.Emergence of new molecular and phage typing variants of E.coli O157:H7 in Canada[M],pp.123.In Duffy G,Garvey P,Coia J,et al(eds.),Verocytotoxigenic E.coli in Europe,vol.5.Epidemiology of Verocytotoxigenic E.coli.Concerted Action CT98-3935.Teagasc,The National Food Centre,Dublin,2001.
[73]Woodward D L,Clark C G,Caldeira R A,et al.Verotoxigenic Escherichia coli (VTEC):A major public health threat in Canada[J].The Canadian Journal of Infectious Diseases.2002.13(5):321-330.
[74]Leotta G A,Miliwebsky E S,Chinen I,et al.Characterisation of shiga toxin-producing Escherichia coli O157 strains isolated from humans in Argentina,Australia and New Zealand[J].BMC Microbiology,2008,8:46-53.
[75]Guth B E C,Chinen I,Miliwebsky E,et al.Serotypes and Shiga toxin genotypes among Escherichia coli isolated from animals and food in Argentina and Brazil[J].Veterinary Microbiology,2003,92(4):335-349.
[76]Nishikawa Y,Hase A,Ogasawara J,et al.Phage typing and DNA-based comparison of strains of Enterohemorrhagic Escherichia coli O157 from apparently sporadic infections in Osaka city.Japan,1996[J].Japanese Journal of Infectious Diseases,2001,54(4):140-143.
[77]Mora A,Blanco J E,Blanco M,et al.Antimicrobial resistance of Shiga toxin (verotoxin)-producing Escherichia coli O157:H7 and non-O157 strains isolated from humans,cattle,sheep and food in Spain[J].Research in Microbiology,2005,156(7):793-806.
[1]Suttle C A.Viruses in the sea[J].Nature,2005,437(7057):356-361.
[2]Inal J M.Phage therapy:a reappraisal of bacteriophages as antibiotics[J].Archivum Immunologiae Et Therapiae Experimentalis (Warsaw),2003,51(4):237-244.
[3]Matsuzaki S,Rashel M,Uchiyma J,et al.Bacteriophage therapy:a revitalized therapy against bacterial infectious diseases[J].Journal of Infection and Chemotherapy,2005,119(5):211-219.
[4]Ackermann H W,Krisch H M.A catalogue of T4-type bacteriophages[J].Archives of Virology,1997,142(12):2329-2345.
[5]Dabrowska K,Switala-Jelen K,Opolski A,et al.Bacteriophage penetration in vertebrates[J].Journal of Applied Microbiology,2005,98(1):7-13.
[6]Brüssow H.Bacteriophage therapy:the Escherichia coli experience[J].Microbiology,2005.151 (7):2133-2140.
[7]Chibani-Chennoufi S,Bruttin A,Dillmann M L,et al.Phage-host Interaction:an ecological perspective[J].Journal of Bacteriology,2004,186(12):3677-3686.
[8]Chibani-Chennoufi S,Sidoti J,Bruttin A,et al.Isolation of Escherichia coli bateriophages from the stool of pediatric diarrhea patients in Bangladesh[J].Journal of Bacteriology,2004,186(24):8287-8294.
[9]Hancock D D,Besser T E,Rice D H,et al.Multiple sources of Escherichia coli O157 in feedlots and dairy farms in the northwestern USA[J].Preventative Veterinary Medicine,1998.35(1):11-19.
[10]Shere J A,Bartlett K J,Kaspar C W.Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1998,64 (4):1390-1399.
[11]Vernozy-Rozand C,Montet M P,Lequerrec F,et al.Prevalence of verotoxin-producing Escherichia coli (VTEC) in slurry,farmyard manure and sewage sludge in France[J].Journal of Applied Microbiology,2002,93(3):473-478.
[12]Hancock D D,Besser T E,Rice D H,et al.A longitudinal study of Escherichia coli O157 in fourteen cattle herds[J].Epidemiology and Infection,1997,118(2):193-195.
[13]Bonardi S,Maggi E,Bottarelli A,et al.Isolation of Verocytotoxin-producing Escherichia coli O157:H7 from cattle at slaughter in ltaly[J].Veterinary Microbiology,1999,67(3):203-211.
[14]Van Donkersgoed J,Berg J,Potter A,et al.Environmental sources and transmission of Escherichia coli O157 in feedlot cattle[J].The Canadian Verterinary Journal,2001,42(9):714-720.
[15]Tanji Y,Shimada T,Yoichi M,et al.Toward rational control of Escherichia coli O157:H7 by a phage cocktail[J].Applied Microbiology and Biotechnology,2004,64(2):270-274.
[16]Capparelli R,Ventimiglia I,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infection,2006,12(3):248-253.
[17]Sheng H,Knecht H J,Kudva 1 T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72 (8):5359-5366.
[18]Raya R R,Varey P,Oot R A,et al.Isolation and characterization of a new T-Even bacteriophage,CEV1,and determination of its potential to reduce Escherichia coli O157:H7 levels in sheep[J].Applied and Environmental Microbiology,2006,72(9):6405-6410.
[19]Viscardi M,Perugini G A,Auriemma C,et al.Isolation and characterisation of two novel coliphages with high potential to control antibiotic-resistant pathogenic Escherichia coli (EHEC and EPEC) [J].International Journal of Antimicrobial Agents,2008,31(2):152-157.
[20]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogens and Disease,2008,5(2):183-191.
[21]Callaway T R,Edrington T S,Brabban A D,et al.Fecal prevalence of Escherichia coli O157,Salmonella,Listeria,and bacteriophage infecting E.coli O157:H7 in feedlot cattle in the southern plains region of the united states[J].Foodborne Pathogens and Disease,2006,3(3):234-244.
[22]Oot R A,Raya R R,Callaway T R,et al.Prevalence of Escherichia coli O157 and O157:H7-infecting bacteriophages in feedlot cattle feces[J].Letters in Applied Microbiology,2007,45(4):445-453.
[23]Sambrook J,Russell D W.Molecular cloning:a laboratory manual-3rd ed[M].Cold Spring Harbor Laboratory Press,Cold Spring Harbor,New York,2001.
[24]SAS Institute,Inc.SAS user guide:statistics,version 9.1[CP].SAS Institute,Cary,N.C.Science Publishing Company,Inc.,New York,1999.
[25]Woolcock J B.Microbiology of animals and animal products[M].Elsevier Science Publishing Company,Inc.,New York,1991.
[26]Williamson S J,Paul J H.Nutrient stimulation of lytic phage production in bacterial populations of the Gulf of Mexico[J].Aquatic Microbial Ecology,2004,36(1):9-17.
[27]Schroder J J,Jansen A G,Hilhorst G J.Long-term nitrogen supply from cattle slurry[J].Soil Use and Management,2005,21(2):196-204.
[28]Eghball B,Wienhold J,Woodbury B L,et al.Phosphorus management-plant availability of phosphorus in swine slurry and cattle feedlot manure[J].American Society of Agronomy,2005,97(2):542-548.
[29]Amon B,Kryvoruchko V,Amona T,et al.Methane,nitrous oxide and ammonia emissions during storage and after application of dairy cattle slurry and influence of slurry treatment[J].Agriculture,Ecosystems and Environment,2006,112(2-3):153-162.
[30]Williamson K E,Radosevich M,Wommack K E.Abundance and Diversity of Viruses in Six Delaware Soils[J].Applied and Environmental Microbiology,2005,71(6):3119-3125.
[31]Step L D,Smith R A.Nonrespiratory disease of stocker cattle[J].The Veterinary Clinics of North America (Food animal practice),2006,22(2):413-434.
[32]Hurst C J,Gerba C P,Cech 1.Effects of environmental variables and soil characteristics on virus survival in soil[J].Applied and Environmental Microbiology,1980,40(6):1067-1079.
[33]Jamalludeen N,Johnson R P,Friendship R,et al.Isolation and characterization of nine bacteriophages that lyse O149 Enterotoxigenic Escherichia coli[J].Veterinary Microbiology,2007,124(1-2):47-57.
[34]Stanford K,Croy D,Bach S J,et al.Ecology of Escherichia coli O157:H7 in commercial dairies in Southern Alberta[J].Journal of Dairy Science,2005,88(12):4441-4451.
[35]Smith W H,Huggins H B,Shaw K M.The control of experimental Escherichia coli diarrhoea in calves by means of bacteriophages[J].Journal of General Microbiology,1987,133(5):1111-1126.
[36]Niu Y D,Xu Y,McAllsiter,T A,et al.Comparison of fecal versus rectoanal mucosal swab sampling for detecting Escherichia coli O157:H7 in experimentally inoculated cattle used in assessing bacteriophage as a mitigation strategy[J].Journal of Food Protection,2008,71(4):691-698.
[37]Hussein H S,Bollinger L M.Prevalence of Shiga toxin-producing Escherichia coli in beef cattle[J].Journal of Food Protection,2005,68(10):2224-2241.
[38]Sanderson M W,Sargeant J M,Shi X,et al.Longitudinal emergence and distribution of Escherichia coli O157 genotypes in a beef feedlot[J].Applied and Environmental Microbiology,2006,72(12):7614-7619.
[39]Wiggins B A,Alexander M.Minimum bacterial density for bacteriophage replication:implications for significance of bacteriophages in natural ecosystems[J].Applied and Environmental Microbiology,1985,49(1):19-23.
[40]Echeverry A,Loneragan G H,Wagner B A,et al.Effect of intensity of fecal pat sampling on estimates of Escherichia coli O157 prevalence[J].American Journal of Veterinary Research,2005,66(12),2023-2027.
[41]McAllister T A,Bach S J,Johnson R P.Use of bacteriophage to control Escherichia coli O157:H7 in beef cattle and the environment[R].Final Report,Project 1.31,Beef Cattle Research Council,Calgary,2005.
[42]Jiang X,Morgan J,doyle M P.Fate of Escherichia coli O157:H7 in manure-amended soil[J].Applied and Environmental Microbiology,2002,68(5):2605-2609.
[43]Berry E D,Miller D N.Cattle feedlot soil moisture and manure content:Ⅱ.Impact on Escherichia coli O157[J].Journal of Environment Quality,2005,34(2):656-663.
[44]Wells J E,Berry E D,Varel V H.Effects of common forage phenolic acids on Escherichia coli O157:H7 viability in bovine feces[J].Applied and Environmental Microbiology,2005,71(12):7974-7979.
[45]Fremaux B,Delignette-Muller M L,Prigent-Combaret C et al.Growth and survival of non-O157:H7 shiga-toxin-producing Escherichia coli in cow manure[J].Journal of Applied Microbiology,2007,102(1):89-99.
[46]Kudva I T,Blanch K,Hovde C J.Analysis of Escherichia coli O157:H7 Survival in Ovine or Bovine Manure and Manure Slurry[J].Applied and Environmental Microbiology,1998.64(9):3166-3174.
[47]Bolton D J,Byrne C M,Sheridan J J,et al.The survival of characteristic of a non-toxigenic strain of Escherichia coli O157:H7[J].Journal of Applied Microbiology,1999,86(3):407-411.
[48]Pisman T I,Pechurkin N S.Host-parasite interactions in closed and open microbial cultivation system[J].Advances in Space Researchrnent,2008,41(5):773-776.
[2]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157-.H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[3]Rangel,J M,Sparling,P H,Crowe C,et al.Epidemiology of Escherichia coli O157:H7 outbreaks.United states,1982-2002[J].Emerging Infectious Diseases,2005,11(4):603-609.
[4]Stevens M P,van Diemen P M,Dziva F,et al.Options for the control of enterohaemorrhagic Escherichia coli in ruminants[J].Microbiology,2002,148(Pt12):3767-3778.
[5]Chapman P A,Malo A T,Siddons C A,et al.Use of commercial enzyme immunoassays and immunomagnetic separation systems for detecting Escherichia coli O157 in bovine fecal samples[J].Applied and Environmental Microbiology,1997,63(7):2549-2553.
[6]Mechie S C,Chapman P A,Siddons C A.A fifteen month study of Escherichia coli O157:H7 in a dairy herd[J].Epidemiology and Infection,1997,118(1):17-25.
[7]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[8]Sulakvelidze A,Alavidze Z,Morris JG Jr.Bacteriophage therapy[J].Antimicrobial Agents and Chemotherapy,2001,45(3):649-659.
[9]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[10]Brüssow H.Phage therapy:the Escherichia coli experience[J].Microbiology,2005,151(Pt7):2133-2140.
[11]Jones J B,Jackson L E,Balogh B,et al.Bacteriophages for plant disease control[J].Annual Review of Phytopathology,2007,45:245-262.
[12]Greer G G.Bacteriophage control of foodborne bacteria[J].Journal of Food Protection,2005,68(5):1102-1111.
[13]Abuladze T,Li M,Menetrez M Y,et al.Bacteriophages reduce experimental contamination of hard surfaces,tomato,spinach,broccoli,and ground beef by Escherichia coli O157:H7[J].Applied and Environmental Microbiology,2008,74(20):6230-6238.
[14]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogens and Disease,2008,5(2):183-191.
[15]Niu Y D,Xu Y,McAllsiter,T A,et al.Comparison of fecal versus rectoanal mucosal swab sampling for detecting Escherichia coliO157:H7 in experimentally inoculated cattle used in assessing bacteriophage as a mitigation strategy[J].Journal of Food Protection,2008,71(4):691—698.
[16]Viscardi M,Perugini G A,Auriemma C,et al.Isolation and characterisation of two novel coliphages with high potential to control antibiotic-resistant pathogenic Escherichia coli (EHEC and EPEC)[J].International Journal of Antimicrobial Agents,2008,31(2):152-157.
[1]Riley L W,Remis R S,Helgerson S D,et al.Hemorrhagic colitis associated with a rare Escherichia coli serotype[J].The New England Journal of Medicine,1983,308(12):381-385.
[2]Wells J G,Davis B R,Wachsmuth 1 K,et al.Laboratory investigation of hemorrhagic colitis outbreaks associated with a rare Escherichia coli serotype[J].Journal of Clinical Microbiology,1983,18(3):512-520.
[3]Whittam T S,Wolfe M L,Wachsmuth I K,et al.Clonal relationships among Escherichia coli strains that cause hemorrhagic colitis and infantile diarrhea[J].Infection and Immunity,1993,61(5):1619-1629.
[4]Reid S D,Herbelin C J,Bumbaugh A C,et al.Parallel evolution of virulence in pathogenic Escherichia coli[J].Nature,2000,406:64-67.
[5]Shaikh N,Tarr P I.Escherichia coli O157:H7 Shiga toxin-encoding bacteriophages:integrations,excisions,truncations,and evolutionary implications[J].Journal of Bacteriology,2003.185(12):3596-3605.
[6]Perna N T,Plunkett G,Burland V,et al.Genome sequence of enterohaemorrhagic Escherichia coli O157:H7[J].Nature,2001,409:529-533.
[7]Griffin P M,Tauxe R V.The epidemiology of infections caused by Escherichia coli O157:H7,other enterohemorrhagic E.coli,and the associated hemolytic uremic syndrome[J].Epidemiology Review,1991,13:60-98.
[8]Paton J C,Paton,A W.Shiga toxigenic Escherichia coli infections[J].Science & Medicine,2000.7(3):28-37.
[9]Su C,Brandt L J.Escherichia coli O157:H7 infection in humans[J].Annals of Internal Medicine,1995,123(9):698-714.
[10]Boyce T G,Swerdlow D L,Griffin P M.Escherichia coli O157 and the haemolytic-uraemic syndrome[J].The New England Journal of Medicine,1995,333(6):364-368.
[11]Lior H.Classification of Escherichia coli[M],pp.31-72.In Gyles C L(ed.),Escherichia coli in domestic animals and humans.CAB International,Wallingford,UK.,1994.
[12]Farmer J J,Davis B R.H7 antiserum-sorbitol fermentation medium for Escherichia coli O157:H7 associated with haemorrhagic colitis[J].Journal of Clinical Microbiology,1985,22(4):620-625.
[13]Thompson J S,Hodge D S,Borczyk A A.Rapid biochemical test to identify verocytotoxin-positive strains of Escherichia coli serotype O157[J].Journal of Clinical Microbiology,1990,28(10):2165-2168.
[14]Doyle M P,Schoeni J L.Survival and growth characteristics of Escherichia coli associated with haemolytic colitis[J].Applied and Environmental Microbiology,1984,48(4):855-856
[15]Nataro J P,Kaper J B.Diarrheagenic Escherichia coli[J].Clinical Microbiological Reviews,1998.11(1):142-201.
[16]Vanselow B A,Krause D O,McSweeney C S.The Shiga toxin-producing Escherichia coli,their ruminant hosts,and potential on-farm interventions:a review[J].Australian Journal of Agriculture Research,2005,56(3):219-214.
[17]McQuigge M,Ellis A,Stratton,et al.A large outbreak of E.coli O157:H7 and Campylobacter infections due to contaminated municipal drinking water[C].'4th International Symposium and Workshop on "Shiga Toxin(Verotoxin)-Produeing infections'.Kyoto,Japan.(VTEC 2000,C/o The Convention:Minarni-Aoyama,Minato-ku,Tokyo),2000.
[18]PHAC.C-EnterNet 2006 Annual Report[EB],2007[2007,11,19].Available at:http://www.phac-aspc.gc.ca/publicat/2OO7/c-enternet06/pdf/O6-areport_e.pdf.
[19]Michel P J B,Wilson S W,Martin R C,et al.Estimation of the under-reporting rate for the surveillance of Escherichia coli O157:H7 cases in Ontario,Canada[J].Epidemiology and Infection,2000,125(1):35-45.
[20]Majowicz S E,Edge V L,Fazil A,et al.Estimating the under-reporting rate for infectious gastrointestinal illness in Ontario[J].Canadian Journal of Public Health,2005,96(3):178-181.
[21]李洪卫,逢波,景怀琦等.徐州市2002年肠出血性大肠埃希菌O157:H7感染性腹泻的调查[J].中华流行病学杂志,2002,23(2):119-122.
[22]汪华.肠出血性大肠杆菌O157:H7流行特征和控制对策研究[J].医学研究通讯,2005.34(5):24-25.
[23]汪华,景怀琦,李洪卫等.江苏省淮北地区肠出血性大肠埃希菌O157:H7感染性腹泻并发急性肾衰的研究[J].中华流行病学杂志,2004,25(11):938-940.
[24]叶方友,林君芬,江夏明.温岭市首例肠出血性大肠杆菌O157:H7感染性腹泻的流行病学调查[J].预防医学情报杂志,2002,18(2):126.
[25]许文香,陈翠平,增明.肠出血大肠埃希菌O157:H7与食品安全[J].卫生研究,2006,35(4):527-528.
[26]张淑红,申志新,关文英等.河北省食品中大肠杆菌O157:H7分布及毒力研究[J].中国卫生检疫杂志,2007,17(1):120-122.
[27]王燕.大肠杆菌O157:H7感染流行概况[J].微生物学免疫学进展,2008,36(1):51-58.
[28]Belongia E A,Osterholm M T,Soler J T,et al.Transmission ofEscherichia coli O157:H7 infection in Minnesota child day-care facilities[J].The Journal of the American Medical Association,1993,269(7):883-888.
[29]Chalmers R M,Aird H,Bolton F J.Waterborne Escherichia coli O157[J].Journal of Applied Microbiology,2000,88:124-132.
[30]Verma A,Bolton F J,Fiefield D,et al.An outbreak of E.coli O157 associated with a swimming pool:an unusual vehicle of transmission[J].Epidemiology and Infecttion,2007,135(6):989-992.
[31]Armstrong G L,Hollingsworth J,Morris Jr J G.Emerging foodborne pathogens:Escherichia coli O157:H7 as a model of entry of a new pathogen into the food supply of the developed world[J].Epidemiologic Reviews,1996,18(1):20-51.
[32]Ogden l D,Hepburn N F,Macrae M,et al.Long-term survival of Escherichia coli O157 on pasture following an outbreak associated with sheep at a scout camp[J].Letters in Applied Microbiology,2002,34(2):100-104.
[33]Rangel J M,Sparling P H,Crowe C,et al.Epidemiology of Escherichia coli O157:H7 outbreaks,United States,1982-2002[J].Emerging Infectious Disease,2005,11(4):603-309.
[34]Bell B P,Goldoft M,Griffin P M,et al.A multistate outbreak of Escherichia coli O157:H7-associated bloody diarrhea and hemolytic uremic syndrome from hamburgers.The Washington Experience[J].The Journal of America Medicine Association,1994,272(17):1349-1353.
[35]Willshaw G A,Thirlwell J,Jones A P,et al.Vero cytotoxin-producing Escherichia coli O157 in beef burgers linked to an outbreak of diarrhea,haemorrhagic colitis and haemolytic ureamic syndrome in Britain[J].Emerging Infectious Disease,1994,3(4):561-565.
[36]Stevenson J,Hanson S.Outbreak of Escherichia coli O157 phage type 2 infection associated with eating precooked meats[J].Communicable disease report.CDR review,1996,6(8):R116-R118.
[37]Besser R E,Lett S M,Weber J T,et al.An outbreak of diarrhea and hemolytic uremic syndrome from Escherichia coli O157:H7 in fresh-pressed apple cider[J].The Journal of America Medicine Association,1993,269(17):2217-2220.
[38]Cody S H,Glynn M K,Farrar J A,et al.An outbreak of Escherichia coli O157:H7 infection from unpasteurized commercial apple juice[J].Annals of Internal Medicine,1999,130(3):202-209.
[39]Ackers M L,Mahon B E,Leahy E,et al.An outbreak of Escherichia coli O157:H7 infections associated with leaf lettuce consumption[J].The Journal of Infectious Disease,1998,177(6):1588-1593.
[40]Hilborn E D,Mermin J H,Mshar P A,et al.A multistate outbreak of Escherichia coli O157:H7 infections associated with consumption of mesclun lettuce[J].Archives of Internal Medicine,1999,159(15):1758-1764.
[41]Todd B.Outbreak:E.coli O157:H7[J].The American journal of nursing,2007,107(2):29-32.
[42]Liptakova A,Siegfried L,Rosocha J,et al.A family outbreak of haemolytic uraemic syndrome and haemorrhagic colitis caused by verocytotoxigenic Escherichia coli O157 from unpasteurised cow's milk in Slovakia[J].Clinical Microbiology and Infection,2004,10(6):576-578.
[43]Espie E,Vaillant V,Mariani-Kurkdjian P,et al.Escherichia coli O157 outbreak associated with fresh unpasteruized goats' cheese[J].Epidemiology and Infection,2006,134(1):143-146.
[44]Beutin L,Geier D,Steinruck H,et al.Prevalence and some properties of Verotoxin (Shiga-like toxin) -producing Escherichia coli in 7 different species of healthy domestic animals[J],Journal of Clinical Microbiology,1993,31(9):2483-2488.
[45]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7-A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[46]Hancock D,Besser T,LeJeune J,et al.The control of VTEC in the animal reservoir[J].International Journal of Food Microbiology,2001.66(1-2):71-78.
[47]Rasmussen M A,Casey T A.Environmental and food safety aspects of Escherichia coli O157:H7 infections in cattle[J].Critical Review in Microbiology,2001,27(2):57-73.
[48]Renter D G,Sargeant J M.Enterohemorrhagic Escherichia coli O157:epidemiology and ecology in bovine production environments[J].Animal Health Research Reviews.2002,3(2):83-94.
[49]Serna A,Boedeker E C.Pathogenesis and treatment of shiga toxin-producing Escherichia coli infections[J].Current Opinion in Gastroenterology,2008.24(1):38-47.
[50]Buchanan R L,Doyle M P.Foodborne disease significance of Escherichia coli O157:H7 and other enterohemorrhagic E.coli[J].Food Technology,1997,51(10):69-76.
[51]Jay M T,Garrett V,Mohle-Boetani J C,et al.A multistate outbreak of Escherichia coli O157:H7 infection linked to consumption of beef tacos at a fast-food restaurant chain[J].Clinical Infectious Disease,2004,39(1):1-7.
[52]Laine E S,Scheftel J M,Boxrud D J,et al.Outbreak of Escherichia coli O157:H7 infections associated with nonintact blade-tenderized frozen steaks sold by door-to-door vendors[J].Journal of Food Protection,2005,68(6):1198-1202.
[53]Maruzumi M,Morita M,Matsuoka Y,et al.Mass food poisoning caused by beef offal contaminated by Escherichia coli O157[J].Japanese Journal of Infectious Disease,2005,58(6):397.
[54]Honish L,Zazulak I,Mahabeer R,et al.Outbreak of Escherichia coli O157:H7 gastroenteritis associated with consumption of beef donairs,Edmonton,Alberta,May-June 2006[J].Canadian Communicable Disease Report,2007,33(2):14-19.
[55]Licence K,Oates K R,Synge B A,et al.An outbreak of E.coli O157 infection with evidence of spread from animals to man through contamination of a private water supply[J].Epidemiology and Infection,2001,26(1):135-138.
[56]Spencer J L,Guan J.Public health implications related to spread of pathogens in manure from livestock and poultry operations[J].Methods in Molecular Biology (Clifton,N.J.),2004,268:503-515.
[57]Renwick S A,Wilson J B,Clarke R C,et al.Evidence of direct transmission of Escherichia coli O157:H7 infection between calves and a human[J].The Journal of Infectious Disease,1993,168(3):792-793.
[58]Synge B A,Hopkins G F,Reilly W J.Possible link between cattle and E.coli O157 infection in a human[J].The Veterinary Record,1993,133(20):507.
[59]Rice D H,Hancock D D,Besser T E.Verotoxigenic E.coli O157 colonization of wild deer and range cattle[J].The Veterinary Record,1995,137(20):524.
[60]Crump J A,Sulka A C,Langer A J,et al.An outbreak of Escherichia coli O157:H7 infections among visitors to a diary farm[J].The New England Journal of Medicine,2002,347(80):555-560.
[61]Ostroff S M,Kobayashi J M,Lewis J H.Infections with Escherichia coli O157:H7 in Washington State.The first year of statewide disease surveillance[J].The Journal of America Medical Association,1989,262(3):355-359.
[62]Martin D L.MacDonald K L,White K E,et al.The epidemiology and clinical aspects of the hemolytic-uremic syndrome in Minnesota[J].The New England Journal of Medicine,1990,323(17):1161-1167.
[63]Hancock D D,Besser T E,Rice D H,et al.A longitudinal study of Escherichia coli O157 in fourteen cattle herds[J].Epidemiology and Infection,1997,118(2):193-195.
[64]Cizek A,Alexa P,Liter(?)k l,et al.Shiga toxin-producing Escherichia coli O157 in feedlot cattle and Norwegian rats from a large-scale farm[J].Letters in Applied Microbiology,1999,28 (6):435-439.
[65]Shinagawa K,Kanehira M,Omoe K,et al.Frequency of Shiga toxin-producing Escherichia coli in cattle at a breeding farm and at a slaughterhouse in Japan[J].Veterinary Microbiology,2000.76(3):305-309.
[66]Gannon V P J,Graham T A,King R,et al.Escherichia coli O157:H7 infection in cows and calves in a beef cattle herd in Alberta,Canada[J].Epidemiology and Infection,2002,129(1):163-172.
[67]Hussein H S,Thran B H,Hall M R,et al.Verotoxin-producing Escherichia coli in culled beef cows grazing rangeland forages[J].Experimental Biology and Medicine,2003,228(4):352-357.
[68]Schurman R D,Hariharan H,Heaney S B,et al.Prevalence and characteristics of Shiga toxin-producing Escherichia coli in beef cattle slaughtered on Prince Edward lsland[J].Journal of Food Protection,2000,63(11):1583-1586.
[69]Thran B H,Hussein H S,Hall M R,et al.Shiga toxin-producing Escherichia coli in beef heifers grazing an irrigated pasture[J].Journal of Food Protection,2001,64(10):1613-1616.
[70]Ezawa A,Gocho F,Kawata K,et al.High prevalence of enterohemorrhagic Escherichia coli (EHEC) O157 from cattle in selected regions of Japan[J].Journal of Veterinary Medical Science,2004,66(5):585-587.
[71]Smith D R,Gray J T,Moxley R A,et al.A diagnosis strategy to determine the Shiga toxin-producing Escherichia coli O157 status of pens of feedlot cattle[J].Epidemiology and Infection,2004,132(2):297-302.
[72]Pearce M C,Jenkins C,Vali L,et al.Temporal shedding patterns and virulence factors of Escherichia coli serogroups O26,O103,O111,O145,and O157 in a cohort of beef calves and their dams[J].Applied and Environmental Microbiology,2004,70(3):1708-1716.
[73]Reinstein S,Fox J T,Shi X,et al.Prevalence of Escherichia coli O157.H7 in the American bison(Bison bison) [J].Journal of Food Protection,2007,70 (11):2555-2560.
[74]Hancock D D,Besser T E,Kinsell M L,et al.The prevalence of Escherichia coli O157.H7 in dairy and beef cattle in Washington State[J].Epidemiology and Infection,1994,113(2):199-207.
[75]Stanford K,Croy D,Bach S J,et al.Ecology of Escherichia coli O157:H7 in commercial dairies in Southern Alberta[J].Journal of Dairy Science,2005,88(12):4441-4451.
[76]Hancock D D,Rice D H,Thomas L A,et al.Epidemiology of Escherichia coli O157 in feedlot cattle[J].Journal of Food Protection,1997,60(5):462-465.
[77]LeJeune J T,Besser T E,Rice D H,et al.Longitudinal study of fecal shedding of Escherichia coli O157:H7 in feedlot cattle:Predominance and persistence of specific clonal types despite massive cattle population turnover[J].Applied and Environmental Microbiology,2004,70(1):377-384.
[78]Padola N L,Sanz M E,Blanco J E,et al.Serotypes and virulence genes of bovine Shiga toxigenic Escherichia coli (STEC) isolated from a feedlot in Argentina[J].Veterinary Microbiology,2004.100(1-2):3-9.
[79]Elder R O,Keen J E,Siragusa G R,et al.Correlation of enterohemorrhagic Escherichia coli O157 prevalence in feces,hides,and carcasses of beef cattle during processing[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):2999-3003.
[80]Renter D G,Checkley S L,Campbell J,et al.Shiga toxin-producing Escherichia coli in the feces of Alberta feedlot cattle[J].Canadian Journal of Veterinary Research,2004,68(2):150-153.
[81]Hussein S H,Bollinger L M.Prevalence of Shiga toxin-producing Escherichia coli in beef cattle[J].Journal of Food Protection,2005,68(10):2224-2241.
[82]Cobbold R,Desmarchelier P.Horizontal transmission of Shiga toxin-producing Escherichia coli within groups of dairy calves[J].Applied and Environmental Microbiology,2002,68(8):4148-4152.
[83]Barham A R,Barham B L,Johnson A K,et al.Effects of the transportation of beef cattle from the feedyard to the packing plant on prevalence levels of Escherichia coli O157 and Salmonella spp[J].Journal of Food Protection,2002,65(2):280-283.
[84]Tutenel A V,Pierard D,Van Hoof J,et al.Molecular characterization of Escherichia coli O157 contamination routes in a cattle slaughter house[J].Journal of Food Protection,2003,66(9):1564-1569.
[85]Nastasijevic 1,Mitrovic R,Buncic S.Occurrence of Escherichia coli O157 on hides of slaughtered cattle[J].Letters in Applied Microbiology,2008,46(1):126-131.
[86]Zhao T,Doyle M P,Shere J,et al.Prevalence of enterohemorrhagic Escherichia coli O157:H7 in a survey of dairy herds[J].Applied and Environmental Microbilogy,1995,61 (4):1290-1293.
[87]Chapman P A,Malo A T,Siddons C A,et al.Use of commercial enzyme immunoassays and immunomagnetic separation systems for detecting Escherichia coli O157 in bovine fecal samples[J].Applied and Environmental Microbiology,1997,63(7):2549-2553.
[88]Mechie S C,Chapman P A,Siddons C A.A fifteen month study of Escherichia coli O157:H7 in a dairy herd[J].Epidemiology and Infection,1997,118(1):17-25.
[89]Pruimboom-Brees 1 M,Morgan T W,Ackermann M R,et al.Cattle lack vascular receptors for Escherichia coli O157:H7 Shiga toxins[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(19):10235-10329.
[90]Hoey D E,Currie C,Else R W,et al.Expression of receptors for verotoxin 1 from Escherichia coli O157 on bovine intestinal epithelium[J].Journal of Medical Microbiology,2002,51(2):143-149.
[91]Lingwood C A.Glycolipid receptors for verotoxin and Helicobacter pylori:role in pathology[J].Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease,1999,1455(2):375-386.
[92]Endo Y,Tsurugi K,Yutsudo T,et al.Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes.RNA N-glycosidase activity of the toxins[J].European Journal of Biochemistry,1988,171(1-2):45-50.
[93]Boerlin P,McEwen S A,Boerlin-Petzold F,et al.Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans[J].Journal of Clinical Microbiology,1999,37(3):497-503.
[94]Hoey D E,Sharp L,Currie C,et al.Verotoxin 1 binding to intestinal crypt epithelial cells results in localization to lysosomes and abrogation of toxicity [J].Cellular Microbiology,2003,5(2):85-97.
[95]Fegan N,Vanderlinde P,Higgs G,et al.The prevalence and concentration of Escherichia coli O157 in faeces of cattle from different production systems at slaughter[J].Journal of Applied Micriobiology,2004,97(2):362-370.
[96]Widiasih D A,Ido N,Omoe K,et al.Duration and magnitude of faecal shedding of Shiga toxin-producing Escherichia coli from naturally infected cattle[J].Epidemiology and Infection,2004.132(1):67-75.
[97]Naylor.S W,Low J C,Besser T E,et al.Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichi coli O157:H7 in the bovine host[J].Infection and Immunity,2003,71(3):1505-1512.
[98]Matthews L,Low J C,Gaily D L,et al.Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(3):547-552.
[99]Omisakin F,MacRae M,Ogden I D,et al.Concentration and prevalence of Escherichia coli O157 in cattle feces at slaughter[J].Applied and Environmental Microbiology,2003,69(5):2444-2447.
[100]Low J C,McKendrick I J,McKechnie C,et al.Rectal carriage of enterohemorrhagic Escherichia coli O157 in slaughtered cattle[J].Applied and Environmental Microbiology,2005,71(1):93-97.
[101]Cray W C,Moon H W.Experimental infection of calves and adult cattle with Escherichia coli O157:H7[J].Applied and Environmental Microbiology,1995,61(4):1586-1590.
[102]Sanderson M W,Besser T E,Gay J M,et al.Fecal Escherichia coli O157:H7 shedding patterns of orally inoculated calves[J].Veterinary Microbiology,1999,69(3):199-205.
[103]Van Baale M J,Sargeant J M,Gnad D P,et al.Effect of forage or grain diets with or without monensin on ruminal persistence and fecal Escherichia coli O157:7 in cattle[J].Applied and Environmental Microbiology,2004,70(9):5336-5342.
[104]Faith N G,Shere J A,Brosch R,et al.Prevalence and clonal nature of Escherichia coli O157:H7 on dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1996,62(5):1519—1525.
[105]Hancock D D,Besser T E,Rice D H,et al.Multiple sources of Escherichia coli O157 in feedlots and dairy farms in the northwestern USA[J].Preventive Veterinary Medicine,1998,35(1):11-19.
[106]Shere J A,Bartlett K J,Kaspar C W.Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1998,64(4):1390-1399.
[107]Sargeant J M,Gillespie J R.Oberst R D,et al.Results of a longitudinal study of the prevalence of Escherichia coli O157:H7 on cow-calf farms[J].American Journal of Veterinary Research,2000,61(11):1375-1379.
[108]Van Donkersgoed J,Berg J,Potter A,et al.Environmental sources and transmission of Escherichia coli O157 in feedlot cattle[J].The Canadian Verterinary Journal,2001,42(9):714-720.
[109]Wang G,Doyle M P.Survival of enterohemorrhagic Escherichia coli O157:H7 in water.Journal of Food Protection,1998,61(6):662-667.
[110]Lynn T V,Hancock D D,Besser T E,et al.The occurrence and replication of Escherichia coli in cattle feeds[J].Journal of Dairy Science,1998,81(4):1102-1108.
[111]Dodd C C,Sanderson M W,Sargeant J M,et al.Prevalence of Escherichia coli O157 in cattle feeds in Midwestern feedlots[J].Applied and Environmental Microbiology,2003,69(9):5243-5247.
[112]Bach S J,Selinger L J,Stanford K,et al.Effect of supplementing corn-or barley-based feedlot diets with canola oil on faecal shedding of Escherichia coli O157:H7 by steers[J].Journal of Applied Microbiology,2005,98(2):464-475.
[113]McAllister T A,Bach S J,Stanford K.Shedding of Escherichia coli O157:H7 by cattle fed diets containing Monensin or Tylosin[J].Journal of Food Protection,2006,69(9):2075-2083.
[114]Fenlon D R,Wilson J.Growth of Escherichia coli O157 in poorly fermented laboratory silage:a possible environmental dimension in the epidemiology of E.coli O157[J].Letters in Applied Microbiology,2000,30(2):118-121.
[115]Wang G,Zhao T,Doyle M P.Fate of enterohemorrhagic Escherichia coli O157:H7 in bovine feces[J].Applied and Environmental Microbiology,1996,62(7):2567-2570.
[116]Kudva 1 T,Blanch K,Hovde C J.Analysis of Escherichia coli O157:H7 Survival in Ovine or Bovine Manure and Manure Slurry[J].Applied and Environmental Microbiology,1998,64(9):3166-3174.
[117]Fenlon D R,Ogden I D,Vinten A,et al.The fate of Escherichia coli and Escherichia coli O157 in cattle slurry after application to the land.Journal of Applied Microbiology,2000,88(29):149S-156S
[118]Berry E D,Miller D N.Cattle feedlot soil moisture and manure content:Ⅱ.Impact on Escherichia coli O157[J].Journal of Environmenal Quality,2005,34(2):656-663.
[119]Jiang X,Morgan J,doyle M P.Fate of Escherichia coli O157:H7 in manure-amended soil[J].Applied and Environmental Microbiology,2002,68(5):2605-2609.
[120]Wells J E,Berry E D,Varel V H.Effects of common forage phenolic acids on Escherichia coli O157:H7 viability in bovine feces[J].Applied and Environmental Microbiology.2005,71(12):7974-7979.
[121]Fremaux B,Delignette-Muller M L,Prigent-Combaret C,et al.Growth and survival of non-O157:H7 shiga-toxin-producing Escherichia coli in cow manure[J].Journal of Applied Microbiology,2006,102(1):89-99.
[122]Van Donkersgoed J,Graham T,Gannon V.The prevalence of verotoxins,Escherichia coli O157:H7,and Salmonella in the feces and rumen of cattle at processing[J].Canadian Veterinary Journal,1999,40(5):332-338.
[123]Chapman P A.Sources of Escherichia coli O157 and experiences over the past 15 years in Sheffield.UK[J].Journal of Applied Microbiology,2000,88(29):51S-60S.
[124]Edrington T S,Callaway T R,Hallford D M,et al.Effects of exogenous melatonin and tryptophan on fecal shedding of E.coli O157:H7 in cattle[J].Microbial Ecology,2008,55(3):553-560.
[125]Keene W E,Sazie K,Kok J,et al.An outbreak of Escherichia coli O157:H7 infections traced to jerky made from deer meat[J].The Journal of the American Medical Association,1997,277(15):1229-1231.
[126]Kudva I T,Hatfield P G,Hovde C J.Characterization of Escherichia coli O157:H7 and other shiga toxin-producing E.coli serotypes from sheep[J].Journal of Clinical Mcirobilogy,1997,35(4):298-299.
[127]Stevens M P,van Diemen P M,Dziva F,et al.Options for the control of enterohaemorrhagic Escherichia coli in ruminants[J].Microbiology,2002,148(Pt12):3767-3778.
[128]LeJeune J T,Wetzel A N.Preharvest control of Escherichia coli O157 in cattle[J].Journal of Animal Science,2007,85(13 Suppl):E73-80.
[129]CDC.Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food-10 sites,United States,2004[EB].MMWR Morbidity and mortality weekly report,2005,54(14):352-356.
[130]USDA.2005.FSIS Ground beef sampling shows substantial E.coli O157:H7 decline in 2004[EB].2005[2006,9,7].http://www.fsis.usda.gov/news_&_events/NR_0228Q5_01 /index.asp.
[131]Roy S L,Lopez A S,Schantz P M.Trichinellosis surveillance—United States,1997-2001 [DB].MMWR Surveilliance Summary,2003,52:1-8.
[132]Pyburn D G,Gamble H R,Wagstrom E A,et al.Trichinae certification in the United States pork industry[J].Veterinary Parasitology,2005,132(1-2):179-183.
[133]Jordan D,McEwen S A,Lammerding A M,et al.Pre-slaughter control of Escherichia coli O157 in beef cattle:A simulation study[J].Preventive Veterinary Medicine,1999,41(1):55-74.
[134]Jordan D,McEwen S A,Lammerding A M,et al.A simulation model for studying the role of pre-slaughter factors on the exposure of beef carcasses to human microbial hazards[J].Preventive Veterinary Medicine,1999,41(1):37-54.
[135]Zhao S,McDermott P F,Friedman S,et al.Antimicrobial resistance and genetic relatedness among Salmonella from retail foods of animal origin:NARMS retail meat surveillance[J].Foodborne Pathogen Disease,2006,3(1):106-117.
[136]Sanderson M W,Sargeant J M,Renter D G,et al.Factors associated with the presence of coliforms in the feed and water of feedlot cattle[J].Applied and Environmental Microbiology,2005,71(10):6026-6032.
[137]Davis M A,Hancock D D,Rice D H.et al.Feedstuffs as a vehicle of cattle exposure to Escherichia coli O157:H7 and Salmonella enterica[S].Veterinary Microbiology,2003,95(3):199-210.
[138]LeJeune J T,Hancock D,Wasteson Y,et al.Comparison of E.coli O157 and Shiga toxin-encoding genes (stx) prevalence between Ohio,USA and Norwegian dairy cattle[J].International Journal of Food Microbiology,2006,109(1-2):19-24.
[139]Boqvist S,Hansson 1,Nord Bjerselius U,et al.Salmonella isolated from animals and feed production in Sweden between 1993 and 1997[J].Acta veterinaria Scandinavica,2003,44(3-4):181-197.
[140]Smith D,Blackford M,Younts S,et al.Ecological relationships between the prevalence of cattle shedding Escherichia coli O157:H7 and characteristics of the cattle or conditions of the feedlot pen[J].Journal of Food Protection,2001,64(12):1899-1903.
[141]Garber L,Wells S,Schroeder-Tucker L,et al.Factors associated with fecal shedding of verotoxin-producing Escherichia coli O157 on dairy farms[J].Journal of Food Protection,1999,62(4):307-312.
[142]Loneragan G H,Brashears M M.Effects of using retention-pond water for dust abatement on performance of feedlot steers and carriage of Escherichia coli O157 and Salmonella spp[J].Journal of the American Veterinary Medical Association,2005.226(8):1378-1383.
[143]Morrow J L.Mitloehner F M,Johnson A K,et al.Effect of water sprinkling on incidence of zoonotic pathogens in feedlot cattle[J].Journal of Animal Science,2005,83(8):1959-1966.
[144]Wilson S C,Morrow-Tesch J,Straus D C,et al.Airborne microbial flora in a cattle feedlot[J].Applied and Environmental Microbiology,2002,68(7):3238-3242.
[145]Zucker B A,Trojan S,Muller W.Airborne gram-negative bacterial flora in animal houses[J].Journal of Veterinary Medicine B,Infectious Diseases and Veterinary Public Health,2000,47:37-46.
[146]Lejeune J T,Kauffman M D.Effect of sand and sawdust bedding materials on the fecal prevalence of Escherichia coli O157:H7 in dairy cows[J].Applied and Environmental Microbiology,2005.71(1):326-330.
[147]Hegde N V,Cook M L,Wolfgang D R,et al.Dissemination of Salmonella enterica subsp.enterica Serovar Typhimurium var.Copenhagen clonal types through a contract heifer-raising operation[J].Journal of Clinical Microbiology,2005,43(8):4208-4211.
[148]Dodson K,LeJeune J.Escherichia coli O157:H7,Campylobacter jejuni,and Salmonella prevalence in cull dairy cows marketed in northeastern Ohio[J].Journal of Food Protection,2005,68(5):927-931.
[149]Vidovic S,Korber D R.Prevalence of Escherichia coli O157 in Saskatchewan cattle:Characterization of isolates by using random amplified polymorphic DNA PCR,antibiotic resistance profiles,and pathogenicity determinants[J].Applied and Environmental Microbiology,2006,72(6):4347-4355.
[150]Daniels M J,Hutchings M R,Greig A.The risk of disease transmission to livestock posed by contamination of farm stored feed by wildlife excreta[J].Epidemiology and Infection.2003.130(3):561-568.
[151]Wetzel A N,LeJeune J T.Clonal dissemination of Escherichia coli O157:H7 subtypes among dairy farms in northeast Ohio[J].Applied and Environmental Microbiology,2006,72(4):2621-2626.
[152]Fuller R.Probiotics in man and animals[J].Journal of Applied Bacteriology,1989,66(5):365-378.
[153]Garber L P,Wells S J,Hancock D D,et al.Risk factors for fecal shedding of Escherichia coli O157:H7 in dairy calves[J].Journal of the American Veterinary Medical Association,1995.207(1):46-49.
[154]Dargatz D,Wells L,Hancock D,et al.Factors associated with the presence of Escherichia coli O157 in the feces of feedlot cattle[J].Journal of Food Protection,1997,60(5):466-470.
[155]Sargeant J M,Sanderson M W,Griffin D D,et al.Factors associated with the presence of Escherichia coli O157 in feedlot-cattle water and feed in the Midwestern USA[J].Preventive Veterinary Medicine,2004,66(1-4):207-237.
[156]Herriott D E,Hancock D D,Ebel E D,et al.Association of herd management factors with colonization of dairy cattle by Shiga toxin-positive Escherichia coli O157[J].Journal of Food Protection,1998,61(7):802-807.
[157]Berg J,McAllister T,Bach S,et al.Escherichia coli O157:H7 excretion by commercial feedlot cattle fed either barley-or corn-based finishing diets[J].Journal of Food Protetion,2004,67(4):666-671.
[158]Diez-Gonzalez F,Callaway T,Kizoulis M,et al.Grain feeding and the dissemination of acid-resistant Escherichia coli from cattle[J].Science,1998,281(5383):1666-1668.
[159]Schrezenmeir J,de Vrese M.Probiotics,prebiotics,and synbiotics—Approaching a defmition[J].The American Journal of Clinical Nutrition.2001,73(suppl):361S-364S.
[160]Nocek J E,Kautz W P.Direct-fed microbial supplementation on ruminal digestion,health,and performance of pre-and postpartum dairy cattle.Journal of Dairy Science,2006,89(1):260-266.
[161]Tournut J.Applications of probiotics to animal husbandry[J].Revue Scientifique et Technique de l'OIE (France),1989,8 (2):551-566.
[162]Brashears M M,Galyean M L,Loneragan G H,et al.Prevalence of Escherichia coli O157:H7 and performance by beef feedlot cattle given Lactobacillus direct-fed microbials[J].Journal of Food Protection,2003,66(5):748-754.
[163]Younts-Dahl S M,Osborn G D,Galyean M L,et al.Reduction of Escherichia coli O157 in finishing beef cattle by various doses of Lactobacillus acidophilus in direct-fed microbials[J].Journal of Food Protection,2005,68(1):6-10.
[164]Elam N A,Gleghorn J F,Rivera J D,et al.Effects of live cultures of Lactobacillus acidophilus (strains NP45 and NP51) and Propionibacterium freudenreichii on performance,carcass,and intestinal characteristics,and Escherichia coli strain O157 shedding of finishing beef steers[J].Journal of Animal Science,2003,81(11):2686-2698.
[165]Zhao T,Doyle M P,Harmon B G.Reduction of carriage of enterohemorrhagic Escherichia coli O157:H7 in cattle by inoculation with probiotic bacteria[J].Journal of Clinical Microbiology,1998,36(3):641-647.
[166]Zhao T,Tkalcic S,Doyle M P,et al.Pathogenicity of enterohemorrhagic Escherichia coli in neonatal calves and evaluation of fecal shedding by treatment with probiotic Escherichia coil[J].Journal of Food Protection,2003,66(6):924-930.
[167]Tkaicic S,Brown C A,Harmon B G,et al.Effects of diet on tureen proliferation and fecal shedding of Escherichia coil O157:H7 in calves[J].Journal of Food Protection,2000,63(12):1630-1636.
[168]Duncan S H,Doherty C J,Govan J R,et al.Characteristics of sheep-rumen isolates of Pseudomonas aeruginosa inhibitory to the growth of Escherichia coli O157[J].FEMS Microbiology Letters,1999,180(2):305-310.
[169]Duncan S H,Booth I R,Flint H J,et al.The potential for the control of Escherichia coli O157 in farm animals[J].Symposium series(Society for Applied Microbiology),2000,29(Suppl):157S-165S.
[170]Takahashi M,Taguchi H,Yamaguchi H,et al.Therapeutic and preventative effect of probiotic bacterium Clostridium butyricium on Enterohaemorrhagic Escheriehia coil O157:H7 infection[C].2000 4th International Symposium and Workshop on "Shiga Toxin(Verotoxin)-producing Escherichia coil Infections." FT"EC 2000Kyoto,Japan.(VTEC 2000,C/o The Convention:Minami-Aoyama,Minato-ku,Tokyo),2000.
[171]Callaway T R,Anderson R C,Edrington T S,et al.What are we doing about Escherichia coil O157:H7 in cattle[J].Journal of Animal Science,2004,82(E-Suppl):E93-99.
[172]de Vaux A,Morrison M,Hutkins R W.Displacement of Escherichia coli O157:H7 from rumen medium containing prebiotic sugars.Applied and Environmental Microbiology,2002,68(2):519-524.
[173]Braden K W,Blanton J R Jr,Allen V G,et al.Ascophyllum nodosum supplementation:a preharvest intervention for reducing Escherichia coil O157:H7 and Salmonella spp.in feedlot steers[J].Journal of Food Protection,2004,67(9):1824-1828.
[174]Bosilevac J M,Nou X,Osborn M S,et al.Development and evaluation of an on-line hide decontamination procedure for use in a commercial beef processing plant[J].Journal of Food Protection,2005,68(2):265-272.
[175]Bosilevac J M,Shackeiford S D,Brichta D M,et al.Efficacy of ozonated and electrolyzed oxidative waters to decontaminate hides of cattle before slaughter[J].Journal of Food Protection,2005,68(7):1393-1398.
[176]Elder R,Keen J,Wittum T,et al.Intervention to reduce fecal shedding of enterohemorrhagic Escherichia coil O157:H7 in naturally infected cattle using neomycin sulphate[C].American Society of Animal Science/American Dairy Science Association,Joint Meeting.Quebec:602,2002.
[177]Woerner D,Ransom J,Sofos J N,et ai.Preharvest processes for microbial control in cattle[J].Food Protection Trends,2006,26:393-400.
[178]Russell J B,Strobel H J.Effect of ionophores on ruminal fermentation[J].Applied and Environmental Microbiology,1989,55(1):1-6.
[179]Russell J B,Houlihan A J.lonophore resistance of ruminal bacteria and its potential impact on human health[J].FEMS Microbiology Review,2003,27(1):65-74.
[180]Callaway T R,Adams K A,Russell J B.The ability of "low g+c gram-positive" ruminal bacteria to resist monensin and counteract potassium depletion[J].Current Microbiology,1999,39(4):226-230.
[181]Callaway T R,Russell J B.Variations in the ability of ruminal gram-negative Prevotella species to resist monensin[J].Current Microbiology,2000,40(1):185-189.
[182]Edrington T S,Callaway T R,Varey P D,et al.Effects of the antibiotic ionophores monensin,lasalocid,laidlomycin propionate and bambermycin on Salmonella and E.coli O157:H7 in vitro[J].Journal of Applied Microbiology,2003,94(2):207-213.
[183]Edrington T S,Callaway T R,Bischoff K M,et al.Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E.coli O157:H7 and Salmonella typhimurium[J].Journal of Animal Science,2003,81(2):553-560.
[184]Lefebvre B,Malouin F,Roy G,et al.Growth performance and shedding of some pathogenic bacteria in feedlot cattle treated with different growth-promoting agents[J].Journal of Food Protection.2006.69(6):1256-1264.
[185]Judge N A,Mason H S,O'Brien A D.Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces[J].Infection and Immunity.2004,72(1):168-175.
[186]Potter A A,Klashinsky S,Li Y,et al.Decreased shedding of Escherichia coli O157:H7 by cattle following vaccination with type Ⅲ secreted proteins[J].Vaccine,2004,22(3-4):362-369.
[187]Peterson R E,Smith D R,Moxley R A,et al.Vaccination for Escherichia coli O157:H7 in Market Ready Feedlot Cattle[R],pp.61-63.Nebraska Beef Report,University of Nebraska,Lincoln,2005.
[188]Van Donkersgoed J,Hancock D,Rogan D,et al.Escherichia coli O157:H7 vaccine field trial in 9 feedlots in Alberta and Saskatchewan[J].The Canadian Veterinary Journal,2005,46(8):724-728.
[189]Conlan J W,KuoLee R,Webb A,et al.Salmonella landau as a live vaccine against Escherichia coli O157:H7 investigated in a mouse model of intestinal colonization[J].Canadian Journal of Microbiology,1999,45(4):723-731.
[190]Conlan J W,KuoLee R,Webb A,et al.Oral immunization of mice with a glycoconjugate vaccine containing the O157 antigen of Escherichia coli O157:H7 admixed with cholera toxin fails to elicit protection against subsequent colonization by the pathogen[J].Canadian Journal of Microbiology.2000,46(3):283-290.
[191]Dziva F,Vlisidou I,Crepin V F,et al.Vaccination of calves with EspA,a key colonisation factor of Escherichia coli O157:H7,induces antigen-specific humoral responses but does not confer protection against intestinal colonisation[J].Veterinary Microbiology,2007,123(1-3):254-261.
[192]van Diemen P M,Dziva F,bu-Median A,et al.Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or 026:H-[J].Veterinary Immunology and Immunopathology,2007,116(1-2):47-58.
[193]Stewart V J.Nitrate respiration in relation to facultative metabolism in enterobacteria[J].Microbiological Review,1988,52(2):190-232.
[194]Callaway T R,Anderson R C,Genovese K J,et al.Sodium chlorate supplementation reduces E.coli O157:H7 populations in cattle[J].Journal of Animal Science,2002,80(6):1683-1689.
[195]Callaway T R,Edrington T S,Anderson R C,et al.Escherichia coli O157:H7 populations in sheep can be reduced by chlorate supplementation^].Journal Food of Protection,2003,66(2):194-199.
[196]Hankin E H.faction bactericide des eaux de la Jumma et du Gange sur le vibrion du cholera[J].Annales de lolnstitut Pateur Micobiologie,1896,10:511.
[197]Samsygina G A,Boni E G.Bacteriophages and phage therapy in pediatric practice[J].Pediatric 1984,4:67-70.
[198]Van Helvoort T.Bacteriological and physiological research styles in the early controversy on the nature of the bacteriophage phenomenon[J].Medical History,1992,3(3):24 3-270.
[199]Adams M H.Bacteriophages[J].Interscience,New York.OCLC 326505,1959.
[200]Summers W C.Felix d'Herelle and the origins of molecular biology[M].Yale University Press,New Haven,Conn.,1999.
[201]d'H(?)relle,F.Sur un microbe invisible antagonize des bacilles dysenteriques[J].Comptes Rendus de l'Acad(?)mie des Sciences (Paris),1917,165:373-375
[202]d' H(?)relle,F.The bacteriophage[J].Science News,1949,14:44-59.
[203]Ackermann,H W.Classification of Bacteriophages,pp.8-16.In R.Calendar (ed.) The Bacteriophages[M].Oxford University Press,New York,2006.
[204]ICTVdB Management 02.043.Myoviridae[DB].In:ICTVdB-The Universal Virus Database,version 4.Büchen-Osmond,C.(Ed),Columbia University,New York,USA,2006
[205]Chibani-Chennoufi S,Bruttin A,Dillmann M L,et al.Phage-host Interaction:an ecological perspective[J].Journal of Bacteriology,2004,186(12):3677-3686.
[206]Kutter E,Gachechiladze A,Poglazov E,et al.Evolution of T4-related phages[J].Virus Genes,1995,11(2-3):285-297.
[207]Sulakvelidze A,Barrow P.Phage therapy in animals and agribusiness[M],pp.335-380.In Kutter E,Sulakvelidze A(eds.),Bacteriophages:Biology and Applications.CRC Press,Boca Raton,Fla,2005.
[208]Sulakvelidze A,Kutter E.Bacteriophage therapy in humans[M],pp.381-436.In Kutter E,Sulakvelidze A(eds.),Bacteriophages:biology and applications.CRC Press,Boca Raton,Fla,2005.
[209]Leiman P G,Kanamani S,Mesyanzhinov V V,et al.Structure and morphogenesis of bacteriophage T4[J].Cellular and Mocleculare life sciences,2003,60(11):2356-2370.
[210]Mosig G,Eiserling F.T4 and related phages:Structure and Development[M],pp.225-267.In Calendar R(ed.),The Bacteriophages.Oxford University Press,New York:,2006.
[211]Matsui T,Griniuvien(?) B,Goldberg E,et al.Isolation and characterization of a molecular chaperone,gp57A,of bacteriophage T4[J].Journal of Bacteriology,1997,179(6):1846-1851.
[212]Burda M R,Miller S.Folding of coliphage T4 short tail fiber in vitro:analysing the role of a bacteriophage-encoded chaperone[J].European Journal of Biochemistry,1999,265(2):771-778.
[213]King J,Mykolajewycz N.Bacteriophage T4 tail assembly:proteins of the sheath,core and baseplate[J].Journal of Molecular Biology,1973,75(2):339-358.
[214]Moody M F,Makowski L.X-ray diffraction study of tail-tubes from bacteriophage T2L[J].Journal of Molecular Biology,1981,150(2):217-244.
[215]DeRosier D J,Klug A.Reconstruction of three dimensional structures from electron micrographs[J].Nature,1968,217:130-134.
[216]Lepault J,Leonard K.Three-dimensional structure of unstained,frozen-hydrated extended tails of bacteriophage T4[J].Journal of Molecular Biology,1985,182(3):431-441.
[217]Coombs D H,Arisaka F.T4 tail structure and function[M],pp.259-281.In Karam J D(ed.),Bacteriophage T4.American Society for Microbiology,Washington,D.C.,1994.
[218]Cerritelli M E,Wall J S,Simon M N,et al.Stoichiometry and domainal organization of the long tail-fiber of bacteriophage T4:A hinged viral adhesion[J].Journal of Molecular Biology.1996.260(5):767-780.
[219]Beckendorf S K.Structure of the distal half of the bacteriophage T4 tail fiber[J].Journal of molecular biology,1973,73(1):37-53.
[220]Makhov A M,Trus B L,Conway J F,et al.The short tail-fiber of bacteriophage T4:molecular structure and a mechanism for its conformational transition[J].Virology.1993,194(1):117-127.
[221]Arisaka F.Assembly and infection process of bacteriophage T4[J].Chaos,2005.15(4):7502(1)-7502(7).
[222]Goldberg E,Grinius L,Letellier L.Recognition,attachment,and injection[M],pp.347-356.In Karam J D,Drake J W,Kreuzer K N,et al(eds.).Molecular Biology of Bacteriophage T4.American Society for Microbiology,Washington,D.C.,1994.
[223]Morita M,Fischer C R,Mizoguchi K,et al.Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coli O157:H7[J].FEMS Microbiology Letters,2002,216(2):243-248.
[224]Riede I.Receptor specificity of the short tail fibres (gp12) of T-even type Escherichia coli phages[J].Molecular and General Genetics,1987,206(1):110-115.
[225]Moody M F.Sheath of bacteriophage T4.Ⅲ.Contraction mechanism deduced from partially contracted sheaths[J].Journal of Molecular Biology,1973,80(4):613-635.
[226]Puck T T,Garen A,Cline J.The mechanism of virus attachment to host cells:1.The roles of ions in the primary reaction[J].The Journal of Experimental Medicine,1951,93(1):65-88.
[227]Guttman B,Raya R,Kutter E.Basic phage biology[M].In Kutter E and Sulakvelidze A(eds.).Bacteriophages:Biology and Applications.CRC Press,Boca Raton,Fla,2005.
[228]Kudva 1 T,Jelacic S,Tarr P I,et al.Biocontrol of Escherichia coli O157 with O157-specific bacteriophages[J].Applied and Environmental Microbiology,1999,65(9):3767-3773.
[229]Abedon S T,Herschel T D,Stopper D.Bacteriophage latent-period evolution as a response to resource availability[J].Applied and Environmental Microbiology,2001,67(9):4233-4241.
[230]Luria,S E,Darnell J E,Baltimore D,et al.General Virology[M].Wiley,New York,1978.
[231]Mosig G,Lin G W,Franklin J,et al.Functional relationships and structural determinants of two bacteriophage T4 lysozymes:A soluble (gene e) and a baseplate-associated (gene 5) protein[J].The New Biologist,1989,1 (2):171-179.
[232]Zoon K C,Habersat M,Scocca J J.Synthesis of envelope polypeptides by Haemophilus influenzae during development of competence for genetic transformation[J].Journal of Bacteriology.1976.127(1):545-554.
[233]Kutter E,Guttman B,Carlson K.The transition from host to phage metabolism after T4 infection[M],pp.343-346.In Karam J D(ed.).Molecular biology of bacteriophage T4.American Society for Microbiology,Washington,D.C,1994.
[234]Kutter E,White T,Kashlev M,et al.Effects on host genome structure and expression[M],pp.357-368.In Karam J D,Drake J W,Kreuzer K N,et al(eds.),Molecular biology of bacteriophage T4.ASM Press,Washington,D.C,1994.
[235]Streisinger G,Mukai F,Dreyer W J,et al.Mutations affecting the lysozyme of phage T4[J].Cold Spring Harbor symposia on quantitative biology,1961,26:25-30.
[236]Lu M-J,Henning U.Lysis protein T of bacteriophage T4[J].Molecular and General Genetics,1992,235(2-3):253-258.
[237]Fischetti V A.Bacteriophage lytic enzymes:novel anti-infectives[J].Trends in Microbiology,2005,13(10):491-496.
[238]Sulakvelidze A,Alavidze Z,Morris JG Jr.Bacteriophage therapy[J].Antimicrobial Agents and Chemotherapy,2001,45(3):649-659.
[239]Ho K.Bacteriophage therapy for bacterial infections.Rekindling a memory from the pre-antibiotics era[J].Perspectives in Biology and Medicine,2001(1),44:1-16.
[240]Bruynoghe R,Maisin J.Essais de therapeutique au moyen du bacteriophage[J].Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales,1921,85:1120-1121.
[241]Rice T B.Use of bacteriophage filtrates in treatment of suppurative conditions:report of 300 cases[J].The American Journal of Medical Science,1930,179(3):345-360.
[242]Schless R A.Staphylococcus aureus meningitis:treatment with specific bacteriophage[J].Archives of Pediatrics and Adolescent Medicine,1932,44:813-822.
[243]Stout B F.Bacteriophage therapy[J].Texas State Journal of Medicine,1933,29:205-209.
[244]Smith H W,Huggins M B.Effectiveness of phages in treating experimental Escherichia coli diarrhoea in calves,piglets and lambs[J].Journal of General Microbiology,1983,129(8):2659-2675.
[245]Smith H W,Huggins M B,Shaw K M.Factors influencing the survival and multiplication of bacteriophages in calves and in their environment[J].Journal of General Microbiology,1987.133(5):1127-1135.
[246]Smith H W,Huggins H B,Shaw K M.The control of experimental Escherichia coli diarrhoea in calves by means of bacteriophages[J].Journal of General Microbiology,1987,133(5):1111-1126.
[247]Barrow P,Lovell M,Berchieri A Jr.Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves[J].Clinical and Diagnostic Laboratory Immunity,1998,5(3):294-298.
[248]Lee N,Harris D L.The effect of bacteriophage treatment to reduce the rapid dissemination of Salmonella typhimurium in pigs[J].Proceedings of the American Association of Swine Veterinarians,2001,32:555-557.
[249]Huff W E,Huff G R,Rath N C,et al.Prevention of escherichia coli infection in broiler chickens with a bacteriophage aerosol spray[J].Poultry Science,2002,81(10):1486-1491.
[250]Huff W E,Huff G R,Rath N C,et al.Bacteriophage treatment of a severe Escherichia coli respiratory infection in broiler chickens[J].Avian Diseases,2003,47(4):1399-1405.
[251]Huff W E,Huff G R,Rath N C,et al.Evaluation of aerosol spray and intramuscular injection of bacteriophage to treat an Escherichia coli respiratory infection[J].Poultry Science.2003,82(7):1108-1112.
[252]Huff W E,Huff G R,Rath N C,et al.Evaluation of the influence of bacteriophage titer on the treatment of colibacillosis in broiler chickens[J].Poultry Science,2006,85(8):1373-1377.
[253]Loc Carrillo C,Atterbury R J,el-Shibiny A,et al.Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens[J].Applied and Environmental Microbiology,2005,71(11):6554-6563.
[254]Borie C,Albala 1,Sanchez P,et al.Bacteriophage treatment reduces Salmonella colonization of infected chickens[J].Avian Diseases,2008,52(1):64-67.
[255]Smith H W,Huggins M B.Successful treatment of experimental Escherichia coli infections in mice using phage:its general superiority over antibiotics[J].Journal of General Microbiology,1982,128(2):307-318.
[256]Bogovazova G G,Voroshilova N N,Bondarenko V M.The efficacy of Klebsiella pneumoniae bacteriophage in the therapy of experimental Klebsiella infection[J].Zhurnal mikrobiologii.epidemiologii,i immunobiologii,1991,4:5-8.
[257]Bogovazova G G,Voroshilova N N,Bondarenko V M,et al.lmmunobiological properties and therapeutic effectiveness of preparations from Klebsiella bacteriophages[J].Zhurnal mikrobiologii.epidemiologii,i immunobiologii,1992,3:30-33.
[258]Soothill J S,Lawrence J C,Ayliffe G A J.The efficacy of phages in the prevention of the destruction of pigskin in vitro by Pseudomonas aeruginosa[J].Medical Science Research,1988,16:1287-1288.
[259]Soothill J S.Treatment of experimental infections of mice with bacteriophage[J].Journal of Medical Microbiology,1992,37(4):258-261.
[260]Soothill J S.Bacteriophage prevents destruction of skin grafts by Pseudomonas aeruginosa[i].Burns.1994,20:209-211.
[261]Vijayashree R,Joe A F,Rial D R.Prevention of Clostridium difficile-induced ileocecitis with Bacteriophage[J].Anaerobe,1999,5(2):69-78.
[262]Cao J,Sun Y,Berglindh T,et al.Helicobacter pylori-antigen-binding fragments expressed on the filamentous M13 phage prevent bacterial growth[J].Biochimica et Biophysica Acta,2000,1474(1):107-113.
[263]Biswas B,Adhya S,Wshart P,et al.Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium[J].Infection and Immunity,2002.70(1):204-210.
[264]Cerveny K E,DePaola A,Duckworth D H,et al.Phage therapy of local and systemic disease caused by Vibrio vulnificus in iron-dextran-treated mice[J].Infection and Immunity,2002.70(11):6251-6262.
[265]Matsuzaki S.Yasuda M,Nishikawa H,et al.Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11[J].Journal of Infection Disease.2003,187(4):613-624.
[266]Wang J,Hu B,Xu M,et al.Use of bacteriophage in the treatment of experimental animal bacteremia from imipenem-resistant Pseudomonas aeruginosa[J].International Journal of Molecular Medicine,2006,17(2):309-317.
[267]Wang J,Hu B,Xu M,et al.Therapeutic effectiveness of bacteriophages in the rescue of mice with extended spectrum beta-lactamase-producing Escherichia coli bacteremia[J].International Journal of Molecular Medicine,2006,17(2):347-355.
[268]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[269]Park S C,Shimamura I,Fuktmaga M,et al.Isolation of bacteriophages specific to a fish pathogen,Pseudomonas plecoglossicida,as a candidate for disease control[J].Applied and Environmental Microbiology,2000,66(4):1416-1422.
[270]Park S C,Nakai T.Bacteriophage control of Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis[J].Diseases of aquatic organisms,2003,53(1):33-39.
[271]Imbeault S,Parent S,Lagac(?) M,et al.Using bacteriophages to prevent furunculosis caused by Aeromonas salmonicida in farmed brook trout[J].Journal of Aquatic Animal Health,2006,18:203-214.
[272]Karunasagar I,Shivu M M,Girisha S K,et al.Biocontrol of pathogens in shrimp hatcheries using bacteriophages[J].Aquaculture,2007,268(1-4):288-292.
[273]Nakai T,Sugimoto R,Park K H,et al.Protective effects of bacteriophage on experimental Lactococcus garvieae infection in yellowtail[J].Diseases of aquatic organisms,1999,37(1):33-41.
[274]Jones J B,Jackson L E,Balogh B,et al.Bacteriophages for plant disease control[J].Annual Review of Phytopathoiogy,2007,45:245-262.
[275]Moore E S.d'H(?)relle's bacteriophage in relation to plant parasites[J].South African Journal of Science,1926,23:306.
[276]Momol T,Jones J,Olson S,et al.Integrated management of bacterial spot on tomato in Florida[EB].Rep.PP110,EDIS,Institute of Food Agricultural Science,University of Florida,2002.
[277]Freitag T,Squires R A,Schmid,J.Naturally occurring bacteriophage iyse a largeproportion of canine and feline uropathogenic Escherichia coli isolates in vitro[J].Research in Veterinary Science,2008,85:1-7.
[278]Br(u|¨)ssow H.Phage therapy:the Escherichia coli experience[J].Microbiology,2005,151(7):2133-2140.
[279]Ronner A B,Cliver D O.Isolation and characterization of a coliphage specific for Escherichia coil O157:H7[J].Journal of Food Protection,1990,53:944-947.
[280]杜崇涛,王文东,刘军等.肠出血性大肠杆菌O157:H7噬菌体的分离纯化[J].吉林畜牧兽医.2008,241(29):6-8.
[281]M izoguchi K,Morita M,Fischer C R,et al.Coevolution of bacteriophage PP01 and Escherichia coli O157:H7 in continuous culture[J].Applied and Environmental Microbiology,2003,69(1):170-176.
[282]Tanji Y,Shimada T,Yoiehi M,el al.Toward rational control of Escherichia coli O157:H7 by a phage cocktail[J].Applied Microbiology and Biotechnology,2004,64:270-274.
[283]Fischer C R,Yoichi M,Unno H,et al.The coexistence of Escherichia coli serotype O157:H7 and its specific bacteriophage in continuous culture[J].FEMS Microbiology Letters,2004,241(2):171-177.
[284]Waddell T,Mazzocco,A,Johnson R,et al.Control of Escherichia coli O157:H7 infection of calves by bacteriophages[C].4th International Symposium and Workshop on Shiga toxin (verocytotoxin)-producing Escherichia coli (VTEC 2000) Kyoto,Japan,2000.
[285]Sheng,H,Knecht H J,Kudva I T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72(8):5359-5366.
[286]Bach S J,McAllister T A,Veira D M,et al.Effect of bacteriophage DC22 on Escherichi coli O157:H7 in an artificial rumen system (Rusitec) and inoculated sheep[J].Animal Research,2003,52(2):89-101.
[287]Raya R R,Varey P,Oot R A,et al.Isolation and characterization of a new T-even bacteriophage,CEV1,and determination of its potential to reduce Escherichi coli O157:H7 levels in sheep[J].Applied and Environmental Microbiology,2006,72(9):6405-6410.
[288]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogen Disease,2008,5(2):183-191.
[289]Tanji Y,Shimada T,Fukudomi H,et al.Therapeutic Use of Phage Cocktail for Controlling Escherichia coli O157:H7 in Gastrointestinal Tract of Mice[J].Journal of bioscience and bioengineering,2005,100(3):280-287.
[290]Capparelli R,Ventimiglia I,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infect Diseases,2005,12(3):248-53.
[291]O'Flynn G,Ross R P,Fitzgerald G F,et al.Evaluation of a cocktail of three bacteriophages for biocontrol of Escherichia coli O157:H7[J].Applied Microbiology and Biotechnology,2004,70(6):3417-3424.
[292]Sharma M,Ryu J H,Beuchat L R.Inactivation of Escherichia coli O157:H7 in biofilm on stainless steel by treatment with an alkaline cleaner and a bacteriophage[J].Journal of Applied Microbiology,2005,99(3):449-459.
[293]Abuladze T,Li M,Menetrez M Y,et al.Bacteriophages reduce experimental contamination of hard surfaces,tomato,spinach,broccoli,and ground beef by Escherichia coli O157:H7[J].Applied and Environmental Microbiology,2008,74(20):6230-6238.
[294]Carlton R M,Noordman W H,Biswas B,et al.Bacteriophage P100 for control of Listeria monocytogenes in foods:Genome sequence,bioinformatic analyses,oral toxicity study,and application[J].Regulatory Toxicology and Pharmacology,2005,43(3):301-312.
[295]Embleton M L,Nair S P,Heywood W,et al.Development of a novel targeting system for lethal photosensitization of antibiotic-resistant strains of Staphylococcus aureus[J].Antimicrobial Agents and Chemotherapy,2005,49(9):3690-3696.
[296]Yacoby 1,Shamis M,Bar H,et al.Targeting antibacterial agents by using drug-carrying filamentous bacteriophages[J].Antimicrobial Agents and Chemotherapy,2006,50(6):2087-2097.
[297]Westwater C,Kasman L M,Schofield D A,et al.Use of genetically engineered phage to deliver antimicrobial agents to bacteria:an alternative therapy for treatment of bacterial infections[.l].Antimicrobial Agents and Chemotherapy,2003,47(4):1301-1307.
[298]Hagens S,Hebal A,von Ahsen U,et al.Therapy of experimental pseudomonas infections with a nonreplicating genetically modified phage[J].Antimicrobial Agents and Chemotherapy,2004,48(10):3817-3822.
[299]Larocca D,Brug M A,Jensen-pergakes K,et al.Evolving phage vectors for cell targeted gene delivery[J].Current Pharmaceutical Biotechnology,2002,3(1):45-57.
[300]Jado I,L(?)pez R,Carcia E,et al.Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model[J].Journal of Antimicrobial Chemotherapy,2003,52(6):967-973.
[301]O'Flaherty S,Coffey A,Meaney W,et al.The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant staphylococci,including methicillin-resistant Staphylococcus aureus[J].Journal of Bacteriology,2005,187(20):7161—7164.
[302]Kutter E,Sulakvelidze A.Editors,Bacteriophages:Biology and Applications[M],CRC Press.2005.
[303]Panthel K,Jechlinger W,Matis A,et al.Generation of Helicobacter pylori ghosts by PhiX protein E-mediated inactivation and their evaluation as vaccine candidates[J].Infecttion and Immunity,2003,71(1):109-116.
[304]Ebensen T,Paukner S,Link,C,et al.Bacterial ghosts are an efficient delivery system for DNA vaccines[J].The Journal of Immunology,2004,172(11):6858-6865.
[305]Paukner S,Stidl T,Kudela P,et al.Bacterial ghosts as a novel advanced targeting system for drug and DNA delivery[J].Expert Opinion on Drug Delivery,2006,3(1):11-22.
[306]Skumik M,Strauch E.Phage therapy:facts and fiction[J].International Journal of Medical Microbiology,2006,296(1):5-14.
[307]Goodridge L D.Bacteriophage biocontrol of plant pathogens:fact or fiction[J].Trends in Biotechnology,2004,22(8):384-385.
[308]Petty N K,Evans T J,Fineran P C,et al.Biotechnological exploitation of bacteriophage research[J].Trends Biotechnology.2007,25(1):7-15.
[1]Cobboid R N,Hancock D D,Rice D H,et al.Rectoanal junction colonization of feedlot cattle by Escherichia coli O157:H7 and its association with supershedders and excretion dynamics[J].Applied and Environmental Microbiology,2007,73(5):1563-1568.
[2]Loneragan G H,Brashears M M.Pre-harvest interventions to reduce carriage of E.coli O157 by harvest-ready feedlot cattle[J].Meat Science,2005,71(1):72-78.
[3]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[4]Rice D H,Sheng H Q,Wynia S A,et al.Rectoanal mucosal swab culture is more sensitive than fecal culture and distinguishes Escherichia coli O157:H7-colonized eattle and those transiently shedding the same organism[J].Journal of Clinical Microbiology,2003,41(11):4924-4929.
[5]Greenquist M A,Drouillard J S,Sargeant J M,et al.Comparison of rectoanal mucosal swab cultures and fecal cultures for determining prevalence of Escherichia coli O157:H7 in feediot cattle[J].Applied and Environmental Microbiology,2005,71(10):6431-6433.
[6]Omisakin F,MacRae M,Ogden I D,et al.Concentration and prevalence of Escherichia coil O157 in cattle faeces at slaughter[J].Applied and Environmental Microbiology,2003,69(5):2444-2447.
[7]Bach,S J,Selinger L J,Stanford K,et al.Effect of supplementing corn- or barley-based feedlot diets with canola oil on faecal shedding of Escherichia coli O157:H7 by steers[J].Journal of Applied Microbiology,2005,98(2):464-475.
[8]Chase-Topping M E,McKendrick I J,Pearce M C,et al.Risk factors for the presence of high-level shedders of Escherichia coli O157 on Scottish farms[J].Journal of Clinical Microbiology,2007,45(5):1594-1603.
[9]Chibani-Chennoufi S,Sidoti J,Buttin A,el al.In vitro and in vivo bacteriolytic activities of Escherichia coli phages:implications for phage therapy[J].Antimicrobial Agents and Chemotherapy,2004,8(7):2558-2569.
[10]Dabrowska K,Switala-Jelen K,Oposki A,et al.Bacterophage penetration in vertebrates[J].Journal of Applied Microbiology,2005,98(1):7-13.
[11]Capparelli R,Ventimiglia,I,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infection,2006,12(3):248-253.
[12]Sheng H,Knecht H J,Kudva I T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72(8):5359-5366.
[13]Echeverry A,Loneragan G H,Wagner B A,et al.Effect of intensity of feeai pat sampling on estimates of Escherichia coli O157 prevalence[J].American Journal of Veterinary Research,2005,66(12):2023-2027.
[14]Khaltsa M L,Bauer M L,Gibbs P S,et al.Comparison of two sampling methods for Escherichia coli O157:H7 detection in feedlot cattle[J].Journal of Food Protection,2005,68(8):1724-1728.
[15]Schamberger G P,Diez-Gonzalez F.Assessment of resistance to colicinogenic Escherichia coli by E.coli O157:H7 strains[J].Journal of Applied Microbiology,2005,98(1):245-252.
[16]Smith D,Blackford M,Younts S,et al.Ecological relationships between the prevalence of cattle shedding Escherichia coli O157:H7 and characteristics of the cattle or conditions of the feedlot pen[J].Journal of Food Protection,2001,64(12):1899-1903.
[17]Naylor,S W,Low J C,Besser T E,et al.Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host[J].Infection and Immunity,2003,71(3):1505-1512.
[18]Fox J T,Depenbusch B E,Drouillard J S,et al.Dry-rolled or steam-flaked grain-based diets and fecal shedding of Escherichia coli O157 in feedlot cattle[J].Journal of Animal Science,2007,85(5):1207-1212.
[19]Lim J Y,Li J,Sheng H,et al.Escherichia coli O157:H7 colonization at the rectoanal junction of long-duration culture-positive cattle[J].Applied and Environmental Microbiology,2007,73(4):1380-1382.
[20]Reinstein S,Fox J T,Shi X,et al.Prevalence of Escherichia coli O157:H7 in the American bison (Bison bison) [J].Journal of Food Protection,2007,70(11):2555-2560.
[21]McAllister T A,Bach S J,Stanford K,et al.Shedding of Escherichia coli O157:H7 by cattle fed diets containing monensin or tylosin[J].Journal of Food Protection,2006,69(9):2075-2083.
[22]Garc(?)a-S(?)nchez A,S(?)nchez S,Rubio R,et al.Presence of Shiga toxin-producing E.coli O157:H7 in a survey of wild artiodactyls[J].Veterinary Microbiology,2007,121(3-4):373-377.
[23]Davis M A,Rice D H,Sheng H,et al.Comparison of cultures from rectoanal-junction mucosal swabs and feces for detection of Escherichia coli O157 in dairy heifers[J].Applied and Environmental Microbiology,2006,72(5):3766-3770.
[24]Bach S J,McAllister T A,Veira D M,et al.Effect of bacteriophage DC22 on Esherichia coli O157:H7 in an artifical rumen system (Rusitec) and inoculated sheep[J].Animal Research,2003,52(2):89-101.
[25]Sambrook J,Russell D W.Molecular cloning:a laboratory manual-3~(rd) ed[M].Cold Spring Harbor Laboratory Press,Cold Spring Harbor,New York,2001.
[26]Khaitsa M L,Smith D R,J.Stoner A,et al.Incidence,duration,and prevalence of Escherichia coli O157:H7 fecal shedding by feedlot cattle during the feeding period[J].Journal of Food Protection,2003,66(11):1972-1977.
[27]SAS Institute,Inc.SAS user guide:statistics,version 9.1[CP].SAS Institute,Cary,N.C.Science Publishing Company,Inc.,New York,1999.
[28]Cray W C,Moon H W.Experimental infection of calves and adult cattle with Escherichia coli O157:H7[J].Applied and Environmental Microbiology,1995,61(4):1586-1590.
[29]Elder R O,Keen J E,Siragusa G R,et al.Correlation of Enterohaemorrhagic Escherichia coli O157 prevalence in feces and carcasses of beer cattle during progressing[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):2999-3003.
[30]Serna,A,Boedeker E C.Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections[J].Current Opinion in Gastroenterology,2008,24(1):38-47.
[31]Tarr P I.Escherichia coli O157:H7:clinical,diagnostic,and epidemiological aspects of human infection[J].Clinical Infectious Diseases,1995,20(1):1-8.
[32]Tauxe R V.Emerging foodborne diseases:an evolving public health challenge[J].Emerging Infectious Disease,1997,3(4):425-434.
[33]Besser T E,LeJeune J T,Rice D.et al.Prevention and control of Escherichia coli O157:H7[M],pp.167-174.In Torrence M E,Isaacson R E(eds.),Microbial Food Safety in Animal Agriculture Current Topics.Iowa State Press,Blackwell Publishing Company,Ames,1A,2003.
[34]Loneragan G H,Brashears M M.Pre-harvest interventions to reduce carriage of E.coli O157 by harvest-ready feedlot cattle[J].Meat Science,2005,71(1):72-78.
[35]Sargeant J M,Amezcua M R,Rajic A,et al.Pre-harvest interventions to reduce the shedding of E.coli O157 in the faeces of weaned domestic ruminants:a systematic review[J].Zoonoses and Public Health,2007,54(6-7):260-277.
[36]Ronner A B,Cliver D O.Isolation and characterization of a coliphage specific for Escherichia coli O157:H7[J].Journal of Food Protection,1990,53:944-947.
[37]Waddell T,Mazzocco A,Johnson R,et al.Control of Escherichia coli O157:H7 infection of calves by bacteriophages[C].4~(th) International Symposium and Workshop on Shiga toxin(verocytotoxin)-producing Escherichia coli (VTEC 2000) Kyoto,Japan,2000.
[38]Smith H W,Huggins M B.Effectiveness of phages in treating experimental Escherichia coli diarrhea in calves,piglets and lambs[J].Journal of General Microbiology,1983,129(8):2659-2675.
[39]Smith H W,Huggins M B,Shaw K M.Factors influencing the survival and multiplication of bacteriophages in calves and in their environment[J].Journal of General Microbiology,1987,133(5):1127-1135.
[40]Hoffmann,M.Animal experiments on the mucosal passage and absorption viremia of T3 phages after oral,tracheal and rectal administration.Zentralblatt fur Bakteriologie,Parasitenkunde,Infektionskrankheiten und Hygiene[C].1.Abt.Medizinisch-hygienische Bakteriologie,Virusforschung und Parasitologic Originale,1965,198(4):371-390.
[41]Brown,C A,Harmon B G,Zhao T,et al.Experimental Escherichia coli O157:H7 carriage in calves[J].Applied and Environmental Microbiology,1997,63(1):27-32.
[42]Grauke L J,Kudva I T,Yoon J W,et al.Gastrointestinal tract location of Escherichia coli O157:H7 in ruminants[J].Applied and Environmental Microbiology,2002,68(5):2269-2277.
[43]Laven R A,Ashmore A,Stewart C S.Escherichia coli in the rumen and colon of slaughter cattle,with particular reference to E.coli O157[J].Veterinary Journal,2003,165(1):78-83.
[44]Naylor S W,Low J C,Besser T E,et al.Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host[J].Infection and Immunity,2003,71(3):1505-1512.
[45]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[46]Dziva F,van Diemen P M,Stevens M P,et al.Identification of Escherichia coli O157:H7 genes influencing colonization of the bovine gastrointestinal tract using signature-tagged mutagenesis[J].Microbiology,2004,150(11)3631-3645.
[47]Sheng H,Lim J Y,Knecht H J,et al.Role of Escherichia coli O157:H7 virulence factors in colonization at the bovine terminal rectal mucosa[J].Infection and Immunity,2006,74(8):4685-4693.
[48]Morita M,Fischer C R,Mizoguchi K,et al.Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coli O157:H7[J].FEMS Microbiology Letters,2002,216(2):243-248.
[49]Rozema E A,Stephens T P,Bach S J,et al.Oral and rectal administration of bacteriophages for control of Escherichia coli O157:H7 in feedlot cattle[J].Journal of Food Protection,2009,72(2):241-250.
[50]Tanji Y,Shimada T,Yoichi M,et al.Toward rational control of Escherichia coli O157:H7 by a phage cocktail[J].Applied Microbiology and Biotechnology,2004,64(2):270-274.
[51]Tanji Y,Shimada T,Fukudomi H,et al.Therapeutic use of phage cocktail for controlling Escherichia coli O157:H7 in gastrointestinal tract of mice[J].Journal of Bioscience and Bioengineering,2005,100(3):280-287.
[52]Payne R J H,Jansen V A A.Phage therapy:the peculiar kinetics of self-replicating pharmaceuticals [J].Clinical pharmacology & therapeutics,2000,68(3):225-230.
[53]Calendar R.The bacteriophages,vol.1[M].Plenum Press,New York,1998.
[54]Vijayashree R,Fralick J A,Rolfe R D.Prevention of Clostridium difficile-induced ileocecitis with bacteriophage[J].Anaerobe,1999,5(2):69-78.
[55]Wiggins B A,Alexander M.Minimum bacterial density for bacteriophage replication:implications for significance of bacteriophages in natural ecosystems[J].Applied and Environmental Microbiology,1985,49(1):19-23.
[56]Chibani-Chennoufi S,Bruttin A,Dillmann M L,et al.Phage-host Interaction:an ecological perspective[J].Journal of Bacteriology,2004,186(12):3677-3686.
[57]Poulsen L K,Lan F,Kristensen C S,et al.Spatial distribution of Escherichia coli in the mouse large intestine inferred from rRNA in situ hybridization[J].Infection and Immunity,1994.62(11):5191-5194.
[58]Vanselow B A,Krause D O,McSweeney C S.The Shiga toxin-producing Escherichia coli,their ruminant hosts,and potential on-farm interventions:a review[J].Australian Journal of Agriculture Research,2005,56(3):219-214.
[59]Shere J A,Bartlett K J,Kaspar C W.Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1998,64(4):1390-1399.
[60]Stanford K,Bach S J,Marx T H,et al.Monitoring Escherichia coli O157:H7 in inoculated and naturally colonized feedlot cattle and their environment[J].Journal of Food Protection,2005,68(1):26-33.
[61]Jordan K N,Maher M M.Sensitive detection of Escherichia coli O157:H7 by conventional plating techniques[J].Journal of Food Protection,2006,69(3):689-692.
[62]Sanderson M W,Gay J M,Hancock D D,et al.Sensitivity of bacterioiogic culture for detection of Escherichia coli O157:H7 in bovine feces[J].Journal of Clinical Microbiology,1995,33(10):2616-2619.
[63]Sanderson M W,Sargeant J M,Nagaraja T G.Effect of pooling bovine fecal samples on the sensitivity of detection of Escherichia coli O157:H7[J].Veterinary Microbiology,2005,110(1-2):125-130.
[64]Irwin K E,Smith D R,Gray T J,et al.Behavior of cattle towards devices to detect food-safety pathogens in feedlot pens[J].Bovine Practice,2002,36:5-9.
[65]Smith D R,Gray J T,Moxiey R A,et al.A diagnostic strategy to determine the Shiga toxin-producing Escherichia coli O157 status of pens of feedlot cattle[J].Epidemiology and Infection,2004,132(2):297-302.
[66]Muller E E,Grabow WOK,Ehlers M M.Immunomagnetic separation ofEscherichia coli Q157:H7 from environmental and wastewater in South Africa[J].Water SA,2003,29:427-432.
[67]Tortorello M L,Reineke K F,Stewart D S,et al.Comparison of methods for determining the presence of Escherichia coli O157:H7 in apple juice[J].Journal ofFood Protection,1998,61(11):1425-1430.
[68]Tutenel A V,Pierard D,Vandekerchove D et al.Sensitivity of methods for the isolation of Escherichia coli O157 from naturally infected bovine faeces[J].Veterinary Microbiology,2003,94(4):341-346.
[69]Wright D J,Chapman P A,Siddons C A.Immunomagnetic separation as a sensitive method for isolating Escherichia-coli O157 from food samples[J].Epidemiology and Infection,1994,113(1):31-39.
[70]Robinson S E,Wright E J,Hart C A,et al.Intermittent and persistent shedding of Escherichia coli O157 in cohorts of naturally infected calves[J].Journal of Applied Microbiology,2004,97(5):1045-1053.
[1]Tarr P I,Gordon C A,Chandler W L.Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome[J].Lancet,2005,365(9464):1073-1086.
[2]Elder R O,Keen J E,Siragusa G R,et al.Correlation of enterohemorrhagic Escherichia coli O157 prevalence in feces,hides,and carcasses of beef cattle during processing[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):2999-3003.
[3]Bach S J,McAllister T A,Veira D M,et al.Transmission and control of Escherichia coli O157:H7:A review[J].Canadian Journal of Animal Science,2002,82(4):475-490.
[4]Rangel J M,Sparling P H,Crowe C,et al.Epidemiology of Escherichia coli O157:H7 outbreaks.United states,1982-2002[J].Emerging Infectious Diseases.2005,11(4):603-609.
[5]Spencer J L,Guan J.Public health implications related to spread of pathogens in manure from livestock and poultry operations[M].Methods in Molecular Biology (Clifton,N.J.),2004,268:503-515.
[6]Serna A,Boedeker E C.Pathogenesis and treatment of shiga toxin-producing Escherichia coli infections[J].Current Opinion in Gastroenterology,2008,24(1):38-47.
[7]Hussein H S,Bollinger L M.Prevalence of Shiga toxin-producing Escherichia coli in beef cattle[J].Journal of Food Protection,2005,68(10):2224-2241.
[8]Stanford K,Croy D,Bach S J,et al.Ecology of Escherichia coli O157:H7 in commercial dairies in Southern Alberta[J].Journal of Dairy Science,2005,88(12):4441-4451.
[9]Sanderson M W,Sargeant J M,Shi X,et al.Longitudinal emergence and distribution of Escherichia coli O157 genotypes in a beef feedlot[J].Applied and Environmental Microbiology,2006,72(12):7614-7619.
[10]Nastasijevic I,Mitrovic R,Buncic S.Occurrence of Escherichia coli O157 on hides of slaughtered cattle[J].Letters in Appied micrcobiology,2007,46(1):126-131.
[11]Oporto B,Esteban J 1,Aduriz G,et al.Escherichia coli O157:H7 and non-O157 shiga toxin-producing E.coli in healthy cattle,sheep and swine herds in northern Spain[J].Zoonoses and Public Health,2008,55(2):73-81.
[12]Sulakvelidze A,Alavidze Z,Morris J G Jr.Bacteriophage therapy[J].Antimicrobial Agents and Chemotherapy,2001,45(3):649-659.
[13]Merril C R,Scholl D,Adhya S.Phage therapy[M],pp.725-739.In Calendar R(ed.).The Bacteriophages.Oxford University Press,New York,2006.
[14]Nakai T,Park S C.Bacteriophage therapy of infectious diseases in aquaculture[J].Research in Microbiology,2002,153(1):13-18.
[15]Brüssow H.Phage therapy:the Escherichia coli experience[J].Microbiology,2005,151(Pt 7):2133-2140.
[16]Jones J B,Jackson L E,Balogh B,et al.Bacteriophages for plant disease controI[J].Annual Review of Phytopathology,2007,45:245-262.
[17]Greer G G.Bacteriophage control of foodborne bacteria[J].Journal of Food Protection,2005.68(5):1102-1111.
[18]Capparelli R,Ventimiglia 1,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infection,2006,12(3):248-253.
[19]Sheng H,Knecht H J,Kudva 1 T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72(8):5359-5366.
[20]Raya R R,Varey P,Oot R A,et al.Isolation and characterization of a new T-Even bacteriophage,CEV1,and determination of its potential to reduce Escherichia coli O157:H7 levels in sheep[J].Applied and Environmental Microbiology,2006,72(9):6405-6410.
[21]Abuladze T,Li M,Menetrez M Y,et al.Bacteriophages reduce experimental contamination of hard surfaces,tomato,spinach,broccoli,and ground beef by Escherichia coli O157:H7[J].Applied and Environmental Microbiology,2008,74(20):6230-6238.
[22]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogens and Disease,2008,5(2):183-191.
[23]Niu Y D,Xu Y,McAllsiter,T A,et al.Comparison of fecal versus rectoanal mucosal swab sampling for detecting Escherichia coli O157:H7 in experimentally inoculated cattle used in assessing bacteriophage as a mitigation strategy[J].Journal of Food Protection,2008,71 (4):691-698.
[24]Viscardi M,Perugini G A,Auriemma C,et al.Isolation and characterisation of two novel coliphages with high potential to control antibiotic-resistant pathogenic Escherichia coli (EHEC and EPEC) [J].International Journal of Antimicrobial Agents,2008,31(2):152-157.
[25]Carlton R M.Phage therapy:Past history and future prospects[J].Archivum Immunologia et Therapiae Experimentalis (Warsz),1999,47(5):267-274.
[26]Skurnik M,Pajunen M,Kilkunen S[J].Biotechnological challenges of phage therapy.Biotechnology Letters,2007,29(7):995-1003.
[27]Sambrook J,Russell D W.Molecular cloning:a laboratory manual-3rd edition[M].Cold Spring Harbor Laboratory Press,Cold Spring Harbor,New York,2001.
[28]Gannon V P,D'Souza S,Graham T,et al.Specific identification of Escherichia coli O157:H7 using multiplex PCR assay[J].Advances in Experimental Medicine and Biology,1997,412:81-82.
[29]Ahmed R,Bopp C,Borczyk A,et al.Phage-typing scheme for Escherichia coli O157:H7[J].Journal of Infectious Diseases,1987,155(4):806-809.
[30]Khakhria R,Duck D,Lior H.Extended phage-typing scheme for Escherichia coli O157:H7[J].Epidemiology and Infection,1990,105(3):511-520.
[31]Bach,S J,Selinger L J,Stanford K,et al.Effect of supplementing corn-or barley-based feedlot diets with canola oil on faecal shedding of Escherichia coli O157:H7 by steers[J].Journal of Applied Microbiology,2005,98(2):464-475.
[32]SAS Institute,Inc.SAS user guide:statistics,version 9.1[CP].SAS Institute,Cary,N.C.Science Publishing Company.Inc..New York.1999.
[33]Frost J A,Smith H R,Willshaw G A,et al.Phage-typing of Vero-cytotoxin(VT) producing Escherichia coli O157 isolated in the United Kingdom[J].Epidemiology and Infection,1989.103(1):73-81.
[34]Waterbury J B,Valois F W.Resistance to co-occurring phages enables marine Synechococcus communities to coexist with cyanophages abundant in seawater[J].Applied and Environmental Microbiology,1993,59(10):3393-3399.
[35]Suttle C A,Chan A M.Marine cyanophages infecting oceanic and coastal strains of Synechococcus:abundance,morphology,cross-infectivity and growth characteristics[J].Marine Ecology Progress Series,1993,92(1-2):99-109.
[36]Wichels A,Biel S S,Gelderblom H R,et al.Bacteriophage diversity in the North Sea[J].Applied and Environmental Microbilogy,1998,64(11):4128-4133.
[37]Weinbauer M G.Ecology of prokaryotic viruses[J].FEMS Microbiology Reviews,2004,28(2):127-181.
[38]Heller K J,Bryniok D.O-antigen-dependent mutant of bacteriophage TS[J].Journal of Virology.1984,49(1):20-25.
[39]Kudva I T,Jelacic S,Tarr P I,et al.Biocontrol ofEscherichia coli O157 with O157-specific bacteriophages[J].Applied and Environmental Microbiology,1999,65(9):3767-3773.
[40]Sharma R S,Mishra V,Mohmmed A,et al.Phage specificity and lipopolysaccarides of stem-and root-nodulating bacteria(Azorhizobium caulinodans,Sinorhizobium spp.,and Rhizobium spp.) of Sesbania spp[J].Archives of Microbiology,2008,189(4):411-418.
[41]Inoue T,Matsuzaki S,Tanaka S.A 26-kDa outer membrane protein,OmpK,common to Vibrio species is the receptor for a broad-host-range vibriophage,KVP40[J].FEMS Microbiology Letters,1995,125(1):101-106.
[42]Inoue T,Matsuzaki S,Tanaka S.Cloning and sequence analysis of Vibrio parahaemolyticus ompK gene encoding a 26-kDa outer membrane protein,OmpK,that serves as receptor for a broad-host-range vibriophage,KVP40[J].FEMS Microbiology Letters,1995,134(2-3):245-249.
[43]Nimmich W,Schmidt G,Krailmann-Wenzel U.Two different Escherichia coli capsular polysaccharide depolymerases each associated with one of the eoliphage phi K5 and phi K20[J].FEMS Microbiology Letters,1991,82(2):137-141.
[44]Scholl D,Rogers S,Adhya S,et al.Bacteriophage K1-5 encodes two different tail fiber proteins,allowing it to infect and replicate on both K1 and K5 strains of Escherichia coli[J].Journal of Virology,2001,75(6):2509-2515.
[45]Perry M B,Maclean L,Griffith D W.Structure of the O-chain polysaccharide of the phenol-phase soluble lipopolysaecharide of Escherichia coli O157:H7[J].Biochemistry and Cell Biology,1986,64(1):21-28.
[46]Iguchi A,lyoda S,Watanabe H,et al.O side chain deficency enhances sensitivity of Escherichia coli to Shiga toxin 2-converting bacteriophages[J].Current Microbiology,2007.54(1):14-19.
[47]Ho T D,Waidor M K.Enterohemorrhagic Escherichia coli O157:H7 gai mutants are sensitive to bacteriophage P1 and defective in intestinal colonization[J].Infection and Immunity,2007,75(4):1661-1666.
[48]Merino S,Camprubi S,Tom(?)s J M.Identification of the cell surface receptor for bacteriophage 18 from Aeromonas hydrophila[J].Research in Microbiology,1990,141(2):173-180.
[49]Yokoto S,Hayashi T,Matsumoto H.Identification of the lipopolysaccharide core region as the receptor site for a cytotoxin converting phage,phi CTX,of Pseudomonas aeruginosa[J].Journal of Bacteriology,1994,176(17):5262-5269.
[50]Morita M,Fischer C R.Mizoguchi K,et al.Amino acid alterations in Gp38 of host range mutants of PP01 and evidence for their infection of an ompC null mutant of Escherichia coil O157:H7[J].FEMS Microbiology Letters.2002,216(2):243-248.
[51]Mutoh N,Furukawa H,Mizushima S.Role of lipopolysaccharide and outer membrane protein of Escherichia coil K-12 in the receptor activity for bacteriophage T4[J].Journal of Bacteriology,1978,136(2):693-699.
[52]Yu F,Yamada H,Mizushima S.Role of lipopolysaccharide in the receptor function for bacteriophage Tulb in Escherichia coil[J].Journal of Bacteriology,1981,148(2):712-715.
[53]Koebnik R.Structural and functional roles the surface-exposed loops of the B-barrel memebrane protein OmpA from Escherichia coli[J].Journal of Bacteriology,1999,181(12):3688-3694.
[54]Power M L,Ferrari B C,Littlefield-Wyer J,et al.A naturally occurring novel allele of Escherichia coli Outer membrane protein A reduces sensitivity to bacteriophage[J].Applied and Environmental Microbiology,2006,72(12):7930-7932.
[55]Heller K J.Molecular interaction between bacteriophage and the gram-negative cell envelop[J].Archives of Microbiology,1992,158(30):235-248.
[56]Adams M H.Bacteriophages[M].Interscience,New York.OCLC 326505,1959.
[57]Arisaka F.Assembly and infection process of bacteriophage T4[J].Chaos,2005,15(4):7502(1)-7502(7).
[58]Williams Smith H,Huggins H B.Successful treatment of experimental Escherichia coli in mice using phages:its general superiority over antibiotics[J].Journal of General Microbiology,1982,128(2),307-318.
[59]Hagens S,Habel A,von Ahsen U,et al.Therapy of experimental Pseudomonas infections with a nonreplicating genetically modified phage[J].Anitmicrobial Agents and Chemotherapy,2004,48(10):3817-3822.
[60]Watanabe R,Mastsumoto T,Sano G,et al.Efficacy of bacteriophage therapy against gut-derived sepsis caused by Pseudomonas aeruginosa in mice[J].Antimicrobial Agents and Chemotherapy 2007,51(2):446-452.
[61]Matsuzaki S,Yasuda M,Nishikawa H,et al.Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11[J].Journal of Infection Disease.2003,187(4):613-624.
[62]Capparelli R,Parlato M,Bordello G,et al.Experimental phage therapy against Staphylococcus aureus in mice[J].Anitmicrobial Agents and Chemotherapy 2007,51(8):2765-2773.
[63]Biswas B,Adhya S,Washart P,et al.Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium[J].Infection and Immunity,2002,70(1):204-210.
[64]Carlton R M,Noordman W H,Biswas B,et al.Bacteriophage P100 for control of Listeria monocytogenes in foods:Genome sequence,bioinformatic analyses,oral toxicity study,and application[J].Regulatory Toxicology and Pharmacology,2005,43(3):301-312.
[65]Tanji Y,Shimada T,Fukudomi H,et al.Therapeutic use of phage cocktail for controlling Escherichia coli O157:H7 in gastrointestinal tract of mice[J].Journal of Bioscience and Bioengineering,2005,100(3):280-287.
[66]Yoichi M,Morita M,Mizoguchi K,et al.The criterion for selecting effective phage for Escherichia coli O157:H7 control[J].Biochemical Engineering Journal,2004,19(3):221-227.
[67]Mizoguchi K,Morita M,Fischer C R,et al.Coevolution of bacteriophage PP01 and Escherichia coli O157:H7 in continuous culture[J].Applied and Environmental Microbiology,2003,69(1):170-176.
[68]Park S C,Shimamura 1,Fukunaga M,et al.Isolation of bacteriophages specific to a fish pathogen,Pseudomonas plecoglossicida,as a candidate for disease control[J].Applied and Environmental Microbiology,2000,66(4):1416-1422.
[69]Santander J,Rogeson J.Phage-resistance of Salmonella enterica serovar Enteritidis and pathogenesis in Caenorhabditis elegans is mediated by the lipopolysaccharide[J].Electronic Journal of Biotechnology,2007,10(4):627-632.
[70]Ebert D.Experimental evolution of parasites[J].Science,1998,282(5393):!432-1436.
[71]Mora A,Leon S L,Blanco M,et al.Phage types,virulence genes and PFGE profiles of Shiga toxin-producing Escherichia coli O157:H7 isolated from raw beef,soft cheese and vegetables in Lima (Peru) [J].International Journal of Food Microbiology,2007,114(2):204-210.
[72]Ahmed R,Ali A,Demczuk W,et al.Emergence of new molecular and phage typing variants of E.coli O157:H7 in Canada[M],pp.123.In Duffy G,Garvey P,Coia J,et al(eds.),Verocytotoxigenic E.coli in Europe,vol.5.Epidemiology of Verocytotoxigenic E.coli.Concerted Action CT98-3935.Teagasc,The National Food Centre,Dublin,2001.
[73]Woodward D L,Clark C G,Caldeira R A,et al.Verotoxigenic Escherichia coli (VTEC):A major public health threat in Canada[J].The Canadian Journal of Infectious Diseases.2002.13(5):321-330.
[74]Leotta G A,Miliwebsky E S,Chinen I,et al.Characterisation of shiga toxin-producing Escherichia coli O157 strains isolated from humans in Argentina,Australia and New Zealand[J].BMC Microbiology,2008,8:46-53.
[75]Guth B E C,Chinen I,Miliwebsky E,et al.Serotypes and Shiga toxin genotypes among Escherichia coli isolated from animals and food in Argentina and Brazil[J].Veterinary Microbiology,2003,92(4):335-349.
[76]Nishikawa Y,Hase A,Ogasawara J,et al.Phage typing and DNA-based comparison of strains of Enterohemorrhagic Escherichia coli O157 from apparently sporadic infections in Osaka city.Japan,1996[J].Japanese Journal of Infectious Diseases,2001,54(4):140-143.
[77]Mora A,Blanco J E,Blanco M,et al.Antimicrobial resistance of Shiga toxin (verotoxin)-producing Escherichia coli O157:H7 and non-O157 strains isolated from humans,cattle,sheep and food in Spain[J].Research in Microbiology,2005,156(7):793-806.
[1]Suttle C A.Viruses in the sea[J].Nature,2005,437(7057):356-361.
[2]Inal J M.Phage therapy:a reappraisal of bacteriophages as antibiotics[J].Archivum Immunologiae Et Therapiae Experimentalis (Warsaw),2003,51(4):237-244.
[3]Matsuzaki S,Rashel M,Uchiyma J,et al.Bacteriophage therapy:a revitalized therapy against bacterial infectious diseases[J].Journal of Infection and Chemotherapy,2005,119(5):211-219.
[4]Ackermann H W,Krisch H M.A catalogue of T4-type bacteriophages[J].Archives of Virology,1997,142(12):2329-2345.
[5]Dabrowska K,Switala-Jelen K,Opolski A,et al.Bacteriophage penetration in vertebrates[J].Journal of Applied Microbiology,2005,98(1):7-13.
[6]Brüssow H.Bacteriophage therapy:the Escherichia coli experience[J].Microbiology,2005.151 (7):2133-2140.
[7]Chibani-Chennoufi S,Bruttin A,Dillmann M L,et al.Phage-host Interaction:an ecological perspective[J].Journal of Bacteriology,2004,186(12):3677-3686.
[8]Chibani-Chennoufi S,Sidoti J,Bruttin A,et al.Isolation of Escherichia coli bateriophages from the stool of pediatric diarrhea patients in Bangladesh[J].Journal of Bacteriology,2004,186(24):8287-8294.
[9]Hancock D D,Besser T E,Rice D H,et al.Multiple sources of Escherichia coli O157 in feedlots and dairy farms in the northwestern USA[J].Preventative Veterinary Medicine,1998.35(1):11-19.
[10]Shere J A,Bartlett K J,Kaspar C W.Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin[J].Applied and Environmental Microbiology,1998,64 (4):1390-1399.
[11]Vernozy-Rozand C,Montet M P,Lequerrec F,et al.Prevalence of verotoxin-producing Escherichia coli (VTEC) in slurry,farmyard manure and sewage sludge in France[J].Journal of Applied Microbiology,2002,93(3):473-478.
[12]Hancock D D,Besser T E,Rice D H,et al.A longitudinal study of Escherichia coli O157 in fourteen cattle herds[J].Epidemiology and Infection,1997,118(2):193-195.
[13]Bonardi S,Maggi E,Bottarelli A,et al.Isolation of Verocytotoxin-producing Escherichia coli O157:H7 from cattle at slaughter in ltaly[J].Veterinary Microbiology,1999,67(3):203-211.
[14]Van Donkersgoed J,Berg J,Potter A,et al.Environmental sources and transmission of Escherichia coli O157 in feedlot cattle[J].The Canadian Verterinary Journal,2001,42(9):714-720.
[15]Tanji Y,Shimada T,Yoichi M,et al.Toward rational control of Escherichia coli O157:H7 by a phage cocktail[J].Applied Microbiology and Biotechnology,2004,64(2):270-274.
[16]Capparelli R,Ventimiglia I,Roperto S,et al.Selection of an Escherichia coli O157:H7 bacteriophage for persistence in the circulatory system of mice infected experimentally[J].Clinical Microbiology and Infection,2006,12(3):248-253.
[17]Sheng H,Knecht H J,Kudva 1 T,et al.Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants[J].Applied and Environmental Microbiology,2006,72 (8):5359-5366.
[18]Raya R R,Varey P,Oot R A,et al.Isolation and characterization of a new T-Even bacteriophage,CEV1,and determination of its potential to reduce Escherichia coli O157:H7 levels in sheep[J].Applied and Environmental Microbiology,2006,72(9):6405-6410.
[19]Viscardi M,Perugini G A,Auriemma C,et al.Isolation and characterisation of two novel coliphages with high potential to control antibiotic-resistant pathogenic Escherichia coli (EHEC and EPEC) [J].International Journal of Antimicrobial Agents,2008,31(2):152-157.
[20]Callaway T R,Edrington T S,Brabban A D,et al.Bacteriophage isolated from feedlot cattle can reduce Escherichia coli O157:H7 populations in ruminant gastrointestinal tracts[J].Foodborne Pathogens and Disease,2008,5(2):183-191.
[21]Callaway T R,Edrington T S,Brabban A D,et al.Fecal prevalence of Escherichia coli O157,Salmonella,Listeria,and bacteriophage infecting E.coli O157:H7 in feedlot cattle in the southern plains region of the united states[J].Foodborne Pathogens and Disease,2006,3(3):234-244.
[22]Oot R A,Raya R R,Callaway T R,et al.Prevalence of Escherichia coli O157 and O157:H7-infecting bacteriophages in feedlot cattle feces[J].Letters in Applied Microbiology,2007,45(4):445-453.
[23]Sambrook J,Russell D W.Molecular cloning:a laboratory manual-3rd ed[M].Cold Spring Harbor Laboratory Press,Cold Spring Harbor,New York,2001.
[24]SAS Institute,Inc.SAS user guide:statistics,version 9.1[CP].SAS Institute,Cary,N.C.Science Publishing Company,Inc.,New York,1999.
[25]Woolcock J B.Microbiology of animals and animal products[M].Elsevier Science Publishing Company,Inc.,New York,1991.
[26]Williamson S J,Paul J H.Nutrient stimulation of lytic phage production in bacterial populations of the Gulf of Mexico[J].Aquatic Microbial Ecology,2004,36(1):9-17.
[27]Schroder J J,Jansen A G,Hilhorst G J.Long-term nitrogen supply from cattle slurry[J].Soil Use and Management,2005,21(2):196-204.
[28]Eghball B,Wienhold J,Woodbury B L,et al.Phosphorus management-plant availability of phosphorus in swine slurry and cattle feedlot manure[J].American Society of Agronomy,2005,97(2):542-548.
[29]Amon B,Kryvoruchko V,Amona T,et al.Methane,nitrous oxide and ammonia emissions during storage and after application of dairy cattle slurry and influence of slurry treatment[J].Agriculture,Ecosystems and Environment,2006,112(2-3):153-162.
[30]Williamson K E,Radosevich M,Wommack K E.Abundance and Diversity of Viruses in Six Delaware Soils[J].Applied and Environmental Microbiology,2005,71(6):3119-3125.
[31]Step L D,Smith R A.Nonrespiratory disease of stocker cattle[J].The Veterinary Clinics of North America (Food animal practice),2006,22(2):413-434.
[32]Hurst C J,Gerba C P,Cech 1.Effects of environmental variables and soil characteristics on virus survival in soil[J].Applied and Environmental Microbiology,1980,40(6):1067-1079.
[33]Jamalludeen N,Johnson R P,Friendship R,et al.Isolation and characterization of nine bacteriophages that lyse O149 Enterotoxigenic Escherichia coli[J].Veterinary Microbiology,2007,124(1-2):47-57.
[34]Stanford K,Croy D,Bach S J,et al.Ecology of Escherichia coli O157:H7 in commercial dairies in Southern Alberta[J].Journal of Dairy Science,2005,88(12):4441-4451.
[35]Smith W H,Huggins H B,Shaw K M.The control of experimental Escherichia coli diarrhoea in calves by means of bacteriophages[J].Journal of General Microbiology,1987,133(5):1111-1126.
[36]Niu Y D,Xu Y,McAllsiter,T A,et al.Comparison of fecal versus rectoanal mucosal swab sampling for detecting Escherichia coli O157:H7 in experimentally inoculated cattle used in assessing bacteriophage as a mitigation strategy[J].Journal of Food Protection,2008,71(4):691-698.
[37]Hussein H S,Bollinger L M.Prevalence of Shiga toxin-producing Escherichia coli in beef cattle[J].Journal of Food Protection,2005,68(10):2224-2241.
[38]Sanderson M W,Sargeant J M,Shi X,et al.Longitudinal emergence and distribution of Escherichia coli O157 genotypes in a beef feedlot[J].Applied and Environmental Microbiology,2006,72(12):7614-7619.
[39]Wiggins B A,Alexander M.Minimum bacterial density for bacteriophage replication:implications for significance of bacteriophages in natural ecosystems[J].Applied and Environmental Microbiology,1985,49(1):19-23.
[40]Echeverry A,Loneragan G H,Wagner B A,et al.Effect of intensity of fecal pat sampling on estimates of Escherichia coli O157 prevalence[J].American Journal of Veterinary Research,2005,66(12),2023-2027.
[41]McAllister T A,Bach S J,Johnson R P.Use of bacteriophage to control Escherichia coli O157:H7 in beef cattle and the environment[R].Final Report,Project 1.31,Beef Cattle Research Council,Calgary,2005.
[42]Jiang X,Morgan J,doyle M P.Fate of Escherichia coli O157:H7 in manure-amended soil[J].Applied and Environmental Microbiology,2002,68(5):2605-2609.
[43]Berry E D,Miller D N.Cattle feedlot soil moisture and manure content:Ⅱ.Impact on Escherichia coli O157[J].Journal of Environment Quality,2005,34(2):656-663.
[44]Wells J E,Berry E D,Varel V H.Effects of common forage phenolic acids on Escherichia coli O157:H7 viability in bovine feces[J].Applied and Environmental Microbiology,2005,71(12):7974-7979.
[45]Fremaux B,Delignette-Muller M L,Prigent-Combaret C et al.Growth and survival of non-O157:H7 shiga-toxin-producing Escherichia coli in cow manure[J].Journal of Applied Microbiology,2007,102(1):89-99.
[46]Kudva I T,Blanch K,Hovde C J.Analysis of Escherichia coli O157:H7 Survival in Ovine or Bovine Manure and Manure Slurry[J].Applied and Environmental Microbiology,1998.64(9):3166-3174.
[47]Bolton D J,Byrne C M,Sheridan J J,et al.The survival of characteristic of a non-toxigenic strain of Escherichia coli O157:H7[J].Journal of Applied Microbiology,1999,86(3):407-411.
[48]Pisman T I,Pechurkin N S.Host-parasite interactions in closed and open microbial cultivation system[J].Advances in Space Researchrnent,2008,41(5):773-776.