加减益胃汤对疲劳综合征（脾气虚证）的临床干预研究
摘要
慢性疲劳综合征(chronic fatigue syndrome,CFS)是现代医学新认识的一种疾病,美国疾病控制中心(center for disease control,CDC)预测CFS将成为21世纪影响人类健康的主要问题之一。慢性疲劳综合征的防治已成为当前的迫切任务。
目的:本课题通过加减益胃汤,对确诊为疲劳综合征的病人进行中医临床干预研究,补益中焦、调整脾胃,通过调整机体内在机制,调整激素水平促使人体各个组织器官功能趋向正常与平衡,为确立疲劳综合征的量化诊断标准、标准化治疗方案提供理论依据及客观实验依据。
方法:对确诊为疲劳综合征的36例病人给予药物(加减益胃汤)干预,疗程1个月,自身前后对照,观察疗效。治疗前后分别抽取血清,检测血清胃泌素、血清表皮生长因子两个胃肠激素,用药前后分别与健康者血清进行对比分析。
结果:治疗组疗效显著,中医证侯总有效率达91.67%。治疗组疗前的血清表皮生长因子、血清胃泌素水平与健康组的此胃肠激素比较具有高度统计学意义(p＜0.01)。治疗组疗后的两激素水平与健康组的两胃肠激素比较无统计学意义(p＞0.05)。治疗组治疗前后的血清表皮生长因子、血清胃泌素水平比较具有高度统计学意义(p＜0.01)。治疗过程中安全,无不良反应出现。
结论:加减益胃汤治疗中医辨证为脾气虚证的疲劳综合征安全有效。血清表皮生长因子、血清胃泌素与疲劳综合征有明显的相关性,为其成为亚健康疲劳综合征诊断和疗效的客观判定标准提供了依据。
Chronic fatigue syndrome is one kind of disease modern medicine new understanding. The US CDC forecast CFS will become one of human health main questions for the 21st century. The chronic fatigue syndrome preventing and controlling has become the current urgent duty.
Objective: This topic through the addition and subtraction profit stomach soup to make the Chinese medicine clinical intervention research for the patient who diagnosis for chronic fatigue syndrome. In benefit burnt. Adjust the spleen and stomach function. Through the adjustment organism intrinsic mechanism to adjustment hormone level. In order to urge the human body each organization organ function trend to be normal and to be balanced. In order to establish the quantification diagnosis standard,the standardized treatment plan which the chronic fatigue syndrome provides the theory basis and the objective experiment rests on.
Methods: 36 example patients who diagnosis for the chronic fatigue syndrome gives the medicine (addition and subtraction profit stomach soup) to intervene. Treatment course 1 month. Own around compares. Observation curative effect. Around the treatment extracts the blood serum separately, the examination blood serum stomach secretes the element(GAS), the blood serum epidermis growth factor(EGF) two gastrointestinal hormones. Around the medication separately carries on the contrast analysis with the health blood serum.
Results: The treatment group curative effect is remarkable, Chinese medicine symptom total effectiveness reaches 91.67%. The treatment group cures front the blood serum EGFand GAS gastrointestinal hormone and the healthy group's hormone comparison has highly statistics significance (p<0.01). The treatment group cures after the blood serum GAS and EGF two gastrointestinal hormones compares with the healthy group's two hormones has the non-statistics significance (p>0.05). Around the treatment group treats the blood serum EGF and GAS gastrointestinal hormone comparison has highly statistics significance (p<0.01).
Conclusion: The addition and subtraction profit stomach soup treat chronic fatigue syndrome Chinese medicine dialectical diagnosis for the spleen lacking in vital energy card weary synthesis is safely and effectively. EGF and GAS has the obvious relevance with Chronic fatigue syndrome. It has provided the basis for EGF and GAS to became the diagnosis and the curative effect objective determination standard of the Chronic fatigue syndrome.
目的:本课题通过加减益胃汤,对确诊为疲劳综合征的病人进行中医临床干预研究,补益中焦、调整脾胃,通过调整机体内在机制,调整激素水平促使人体各个组织器官功能趋向正常与平衡,为确立疲劳综合征的量化诊断标准、标准化治疗方案提供理论依据及客观实验依据。
方法:对确诊为疲劳综合征的36例病人给予药物(加减益胃汤)干预,疗程1个月,自身前后对照,观察疗效。治疗前后分别抽取血清,检测血清胃泌素、血清表皮生长因子两个胃肠激素,用药前后分别与健康者血清进行对比分析。
结果:治疗组疗效显著,中医证侯总有效率达91.67%。治疗组疗前的血清表皮生长因子、血清胃泌素水平与健康组的此胃肠激素比较具有高度统计学意义(p＜0.01)。治疗组疗后的两激素水平与健康组的两胃肠激素比较无统计学意义(p＞0.05)。治疗组治疗前后的血清表皮生长因子、血清胃泌素水平比较具有高度统计学意义(p＜0.01)。治疗过程中安全,无不良反应出现。
结论:加减益胃汤治疗中医辨证为脾气虚证的疲劳综合征安全有效。血清表皮生长因子、血清胃泌素与疲劳综合征有明显的相关性,为其成为亚健康疲劳综合征诊断和疗效的客观判定标准提供了依据。
Chronic fatigue syndrome is one kind of disease modern medicine new understanding. The US CDC forecast CFS will become one of human health main questions for the 21st century. The chronic fatigue syndrome preventing and controlling has become the current urgent duty.
Objective: This topic through the addition and subtraction profit stomach soup to make the Chinese medicine clinical intervention research for the patient who diagnosis for chronic fatigue syndrome. In benefit burnt. Adjust the spleen and stomach function. Through the adjustment organism intrinsic mechanism to adjustment hormone level. In order to urge the human body each organization organ function trend to be normal and to be balanced. In order to establish the quantification diagnosis standard,the standardized treatment plan which the chronic fatigue syndrome provides the theory basis and the objective experiment rests on.
Methods: 36 example patients who diagnosis for the chronic fatigue syndrome gives the medicine (addition and subtraction profit stomach soup) to intervene. Treatment course 1 month. Own around compares. Observation curative effect. Around the treatment extracts the blood serum separately, the examination blood serum stomach secretes the element(GAS), the blood serum epidermis growth factor(EGF) two gastrointestinal hormones. Around the medication separately carries on the contrast analysis with the health blood serum.
Results: The treatment group curative effect is remarkable, Chinese medicine symptom total effectiveness reaches 91.67%. The treatment group cures front the blood serum EGFand GAS gastrointestinal hormone and the healthy group's hormone comparison has highly statistics significance (p<0.01). The treatment group cures after the blood serum GAS and EGF two gastrointestinal hormones compares with the healthy group's two hormones has the non-statistics significance (p>0.05). Around the treatment group treats the blood serum EGF and GAS gastrointestinal hormone comparison has highly statistics significance (p<0.01).
Conclusion: The addition and subtraction profit stomach soup treat chronic fatigue syndrome Chinese medicine dialectical diagnosis for the spleen lacking in vital energy card weary synthesis is safely and effectively. EGF and GAS has the obvious relevance with Chronic fatigue syndrome. It has provided the basis for EGF and GAS to became the diagnosis and the curative effect objective determination standard of the Chronic fatigue syndrome.
引文
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[8]仓恒弘彦,志水彰,渡边恭良.慢性疲劳症候群[J],Biotherapy,2006,20(1):1-5
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