蜈蚣败毒饮治疗寻常型银屑病（瘀滞肌肤型）的临床观察
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摘要
目的探讨蜈蚣败毒饮治疗寻常型银屑病(瘀滞肌肤型)的临床疗效
方法将68例寻常型银屑病(瘀滞肌肤型)患者随机分成2组。A组34例,口服蜈蚣败毒饮,外用紫草油；B组34例,口服复方青黛胶囊,外用紫草油。观察两组治疗前后皮损面积、红斑、鳞屑、浸润的变化。
结果(1)A组总有效率89.41%,B组总有效率73.53%,两组总有效率比较差异有显著性(0.01 结论蜈蚣败毒饮与复方青黛胶囊对寻常型银屑病(瘀滞肌肤型)均具有较好疗效,而前者疗效显著优于后者。
Objective To observe the clinical efficacy of WuGongBaiDu Yin(WGBDY) decoction in the treatment of psoriasis vulgaris(the type of YuZhiJiFu).
Methods We divided the 68cases into two groups.34cases in group A, treated by WGBDY and ZiCaoYou topically.34cases in group B, treated with FuFangQingDaiJiaoNang(FFQDJN) and ZiCaoYou topically. Observe the change of erythema, scleroma,dry scaly skin bits before and after treatment.
Results (1)In group A, the total clear effect rate was 89.41%.In group B, the total clear effect rate was 73.53%.The significant difference was shown statistically between them. (2)Two groups in the symptomatic integral dropped more significantly after the treatment and there were significant difference (P<0.01). (3)WGBDY was more different stastically than FFQDJN in treating soakage (P<0.05).
Conclusion WGBDY and FFQDJN are both effective in the treatment of psoriasis vulgaris(the type of YuZhiJiFu).At the same time, WGBDY is superior to FFQDJN in the clinical efficiency.
方法将68例寻常型银屑病(瘀滞肌肤型)患者随机分成2组。A组34例,口服蜈蚣败毒饮,外用紫草油；B组34例,口服复方青黛胶囊,外用紫草油。观察两组治疗前后皮损面积、红斑、鳞屑、浸润的变化。
结果(1)A组总有效率89.41%,B组总有效率73.53%,两组总有效率比较差异有显著性(0.01
Objective To observe the clinical efficacy of WuGongBaiDu Yin(WGBDY) decoction in the treatment of psoriasis vulgaris(the type of YuZhiJiFu).
Methods We divided the 68cases into two groups.34cases in group A, treated by WGBDY and ZiCaoYou topically.34cases in group B, treated with FuFangQingDaiJiaoNang(FFQDJN) and ZiCaoYou topically. Observe the change of erythema, scleroma,dry scaly skin bits before and after treatment.
Results (1)In group A, the total clear effect rate was 89.41%.In group B, the total clear effect rate was 73.53%.The significant difference was shown statistically between them. (2)Two groups in the symptomatic integral dropped more significantly after the treatment and there were significant difference (P<0.01). (3)WGBDY was more different stastically than FFQDJN in treating soakage (P<0.05).
Conclusion WGBDY and FFQDJN are both effective in the treatment of psoriasis vulgaris(the type of YuZhiJiFu).At the same time, WGBDY is superior to FFQDJN in the clinical efficiency.
引文
[1]中国中医研究院广安门医院编.朱仁康临床经验集,北京人民卫生出版社,1979,156-158
[2]北京中医医院编.赵炳南临床经验集,北京人民卫生出版社,1979.226-227
[3]顾伯华.实用中医外科学,上海科学技术出版杜,1985.490
[4]周鸣歧,周惠君,陈景荣,周升平.辩证分型治疗银屑病302例.中医杂志,1989,30(5)：42-43
[5]孙步云.中医药治疗银屑病226例临床观察,中医杂志,1995,36(2)：99-100
[6]赵成鼎,张新兰,李春梅.谈中医对银屑病的认识和治疗,河南中医,1999,19(2)：20
[7]门军章,曹庭亮.宣法通透论治银屑病的体会,中医药研究,1997,13(1)：39
[8]徐宜厚徐宜厚皮肤病临床经验辑要,中国医药科技出版社,1998,167-169
[9]张志礼张志礼皮肤病临床经验辑要,中国医药科技出版社,2000,115-123
[10]杨晓娜银花虎杖汤治疗寻常型银屑病54例,新中医,2002,34(6)
[11]凌新民克银方治疗寻常型银屑病,中华临床医学杂志,2005,6(6)
[12]王远红扫癣汤治疗寻常型银屑病68例临床观察,中国中医药科技2005,12(2)
[13]曹雪辉凉血解毒方治疗风热血燥型寻常型银屑86例,新中医2001,33(7)
[14]杨茂农 皮炎汤治疗银屑病70例,四川中医,2000,18(1)
[15]陈忠春天花粉汤治疗寻常性银屑病66例,四川中医2004,22(2)
[16]路斌 消银汤治疗寻常型银屑病76例,四川中医2004,22(7)
[17]刘蕤 二地四根汤治疗寻常型银屑病36例,辽宁中医杂志,2004,31(11)
[18]张华 麻杏石甘汤加味治疗寻常型银屑病57例,新中医,2005,37(1)
[19]张云平银屑康汤剂治疗银屑病40例疗效分析,山东医药,2004,44(9)
[20]王雅娟活血通络汤治疗寻常型银屑病80例,陕西中医,2002,23(9)
[21]于德宝中药熏蒸治疗寻常性银屑病疗效观察,中国皮肤性病学杂志,2005,19(3)
[22王淑惠紫色膏封包治疗寻常型银屑病静止期56例,四川中医,2003,21(4)
[23]陈洪 中药药浴治疗银屑病临床观察,中国麻风皮肤病杂志,2001,17(3)
[24]秦秀好 拔火罐加电针治疗银屑病104例,陕西中医,2000,21(8)
[25]马新平耳穴割治加针刺治疗银屑病115例,中国针灸,2004,24(4)
[26]田元生 经络全息联合疗法治疗银屑病36例,中国针灸,2001年7月第21卷第7期
[27]张秀丽 中医埋线治疗寻常型银屑病临床观察,四川中医,2005,23(4)
[28]修猛刚 穴位注射治疗银屑病100例,中国针灸,2005,25(5)
[29]Trem bath RC et al. Hum Mol Genet,1997,6:813-820
[30]Tom forhrde J et al. Science,1994,264:1141-1145
[31]Mattews D et al. nature Genet,1996,14:231-233
[32]Capon F et al. J Invest Dermatol,1999,112:32-35
[33]Enlund F et al. Eur J Hum Genet,1999,7:783-790
[34]Lee YA et al. Am J Hum Genet,2000,67(4):1020-1024
[35]Veal CD et al. J Med Genet,2001,38:7-13
[36Balendran N et al. J Invest Dermatol,1999,113:322-328
[37Oka A et al.Hum Mol Genet,1999,8:2165-2170
[38]Nair R P et al.Alll J Hum Genet,2000,66:1833-1844
[39]Kristensen M, Chu CQ, Eedy DJ, et al. Localization of tumour necrosis factor-alpha(TNF-a)and its receptors in normal and psoriatic skin:epidermal cells express the SS-KD but not the 75 KD TNF receptor [J].Clin Exp Immunol, 1993,94(2):354-362
[40]Bonifati C, Carducci M, Cordiali—Fei P, et al.Correlated increasis of tumour necroses factor-alpha, interleukin-6 and granulocyte fluids and monocyte-colony stimulating factor levels in suction blister patients relationships with disease severity[J] Clin sera of Exp psonati Dermatol,1994, 19(5):383-387.
[41]Pfundt R, Wingens M Bergers M, et al NF-a and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAI kinase-dependent pathway[J]Arch Dermatol Res,2000,292(4):180-187
[42]Fransson J, de-la-Torre B, Hammar H. Psoriatic fibroblasts secrete lower amounts of IL—6 than healthy fibroblasts before and after stimulation with TNF-a [J].Arch Dermatol Res,1999,291(10):538-541
[43]Trembath RC et at. J Rheumatol,1997,24(5):856-859
[44]Balendran N et al. J Invest Dermatol,1999,113(3):322-328
[45]Ohkawara A et al J Rheumatol,1995,22(12):2266-2272
[46]Gladman DD, Farewell VT J Dermatol,1995,22(6):428-433
[47]Gladman DD et al.A rthritis Reum,1998,41(4):588-595
[48]Gonzale S et al. A rthritis Rheum,1999,42(5):1010-1016
[49]Hohler T et al.Br J Dermatol,1996 135(5):738-745
[50]Schmitt GM et al. J Invest Dermatol,1993,100(6):749-752
[51]Jee SH et al.Br.1 Dermatol,1998,139(6):978-983
[52]Jones JL, Berth-Jones J, Fletcher A et al.Assessment of epidermal dendritic cell markers and T-lymphocytes in psoriasis.J Pathol,1994,174(2):77-82
[53]Nickoloff BJ, Wrone-Smith T. Injection of pre-psoriasis skin with CD4+T cells induces Psoriasis. Am J Pathol,1999,155(1):145-158
[54]Paquet P, Pierard GE. Interleukin-6 and the skin [J).Int Arch Allergy Immunol, 1996,109:308
[55]Bonifati C, Trento E, Cordiali-Fei P, et al, Incrcased interleukin-7 concentrations in lesional skin and in the sera of patients with plaque-type psoriasis [J]. C:lin Immunol Immunopathol,1997,83:41
[56]Prens I;, Hegmans J, chin R, et al.Increased expression of interlcukin-4 receptors on psoriatic epidermal cells[Jj Am J pathol,1996,148:1493
[57]Howard M, O Garra A.Biological properties of interleukin-10 [J].Immunol To day,1992 13:198
[58]Leng X, Elias JA.Interleukin-11 inhibits macrophage interleukin-12 producton [J]. J Immunol,1997,159:2161
[59]Fierlbeck G, Rassner G, Muller G. Psoriasis induced at the injection site of recombinant interferon gamma[J]. Arch Dermatol.1990,126(3):351.
[60]王桂芝,刘成玉,纪新强,等.藻酸双醋钠对银屑病病人白细胞流变性及细胞钻附分子表达的影响[[J].青岛大学医学院学报,2000,36(1)：37
[61]Bonifati C, Mussi A, Carducci M, et al.Endothelin-I levels are increased in serand lesional skin extracts of psoriatic patients and correlate with disease severity [J].Acta Derm Venereol (stockh),1998,78:22
[62]lTokura, et al. Arch Dermatol Res,1999,291(7-8):382
[63]Valdimarsson H, et al. Clin Exp Immunol,1997,107(Suppll):21
[64]Valdimarsson H, et al. Immunology Today,1995,16:145
[65]Weissenborn, et al. J Invest Dermatol,1999,113(1):122
[66]Favre M, et al. J Invest Dermatol,1998,110(4).-311
[67]Bonifati C, et al. Clin Exp Dermatol,1994,19:383
[68]Kristensen M, et al. Clin Exp Immunol,1993,94:354
[69]Bonifati C, et al. Clin Exp Dermatol,1994,19:383
[70]Weitzul, et al. Semin Cutan Med Surg,1997,16(3):213
[71]Bunse T, et al. Arch Dermatol Venereol(Stockh),1996,76(1):10
[72]Tsuboi R, et al. Jpn J Med Mycol,1995,36(2):127
[73]Detmar M. Brown LF. Claffey KP. et al. overpression of vascular perinea bility factor/vascular endothelial growth factor and it receptors in psoriasis J Eyp Med、 1994,180:1141-1146
[74]Bhushan M. Mclaughin B.Weiss JB, et al.levels of endothelial cell stimmlatingangiogenesis factor and endothelial growth factor are elevated in psorssis. Br dermatol.1999,141:1054-1060
[75]Farber EM, Bright RP, Nall ML, et al. Psoriasis:a questionaire survery of 2114 patients [J] Arch Dermatol. Farbcr EM, Nicheoloff BJ 1968,18(3):258-259
[76]Recht B, et al. Stress, symmetry and psoriasis:possbile role of neuropeptides[J]J Am Acad Dermato],1986,14(2):305-309
[2]北京中医医院编.赵炳南临床经验集,北京人民卫生出版社,1979.226-227
[3]顾伯华.实用中医外科学,上海科学技术出版杜,1985.490
[4]周鸣歧,周惠君,陈景荣,周升平.辩证分型治疗银屑病302例.中医杂志,1989,30(5)：42-43
[5]孙步云.中医药治疗银屑病226例临床观察,中医杂志,1995,36(2)：99-100
[6]赵成鼎,张新兰,李春梅.谈中医对银屑病的认识和治疗,河南中医,1999,19(2)：20
[7]门军章,曹庭亮.宣法通透论治银屑病的体会,中医药研究,1997,13(1)：39
[8]徐宜厚徐宜厚皮肤病临床经验辑要,中国医药科技出版社,1998,167-169
[9]张志礼张志礼皮肤病临床经验辑要,中国医药科技出版社,2000,115-123
[10]杨晓娜银花虎杖汤治疗寻常型银屑病54例,新中医,2002,34(6)
[11]凌新民克银方治疗寻常型银屑病,中华临床医学杂志,2005,6(6)
[12]王远红扫癣汤治疗寻常型银屑病68例临床观察,中国中医药科技2005,12(2)
[13]曹雪辉凉血解毒方治疗风热血燥型寻常型银屑86例,新中医2001,33(7)
[14]杨茂农 皮炎汤治疗银屑病70例,四川中医,2000,18(1)
[15]陈忠春天花粉汤治疗寻常性银屑病66例,四川中医2004,22(2)
[16]路斌 消银汤治疗寻常型银屑病76例,四川中医2004,22(7)
[17]刘蕤 二地四根汤治疗寻常型银屑病36例,辽宁中医杂志,2004,31(11)
[18]张华 麻杏石甘汤加味治疗寻常型银屑病57例,新中医,2005,37(1)
[19]张云平银屑康汤剂治疗银屑病40例疗效分析,山东医药,2004,44(9)
[20]王雅娟活血通络汤治疗寻常型银屑病80例,陕西中医,2002,23(9)
[21]于德宝中药熏蒸治疗寻常性银屑病疗效观察,中国皮肤性病学杂志,2005,19(3)
[22王淑惠紫色膏封包治疗寻常型银屑病静止期56例,四川中医,2003,21(4)
[23]陈洪 中药药浴治疗银屑病临床观察,中国麻风皮肤病杂志,2001,17(3)
[24]秦秀好 拔火罐加电针治疗银屑病104例,陕西中医,2000,21(8)
[25]马新平耳穴割治加针刺治疗银屑病115例,中国针灸,2004,24(4)
[26]田元生 经络全息联合疗法治疗银屑病36例,中国针灸,2001年7月第21卷第7期
[27]张秀丽 中医埋线治疗寻常型银屑病临床观察,四川中医,2005,23(4)
[28]修猛刚 穴位注射治疗银屑病100例,中国针灸,2005,25(5)
[29]Trem bath RC et al. Hum Mol Genet,1997,6:813-820
[30]Tom forhrde J et al. Science,1994,264:1141-1145
[31]Mattews D et al. nature Genet,1996,14:231-233
[32]Capon F et al. J Invest Dermatol,1999,112:32-35
[33]Enlund F et al. Eur J Hum Genet,1999,7:783-790
[34]Lee YA et al. Am J Hum Genet,2000,67(4):1020-1024
[35]Veal CD et al. J Med Genet,2001,38:7-13
[36Balendran N et al. J Invest Dermatol,1999,113:322-328
[37Oka A et al.Hum Mol Genet,1999,8:2165-2170
[38]Nair R P et al.Alll J Hum Genet,2000,66:1833-1844
[39]Kristensen M, Chu CQ, Eedy DJ, et al. Localization of tumour necrosis factor-alpha(TNF-a)and its receptors in normal and psoriatic skin:epidermal cells express the SS-KD but not the 75 KD TNF receptor [J].Clin Exp Immunol, 1993,94(2):354-362
[40]Bonifati C, Carducci M, Cordiali—Fei P, et al.Correlated increasis of tumour necroses factor-alpha, interleukin-6 and granulocyte fluids and monocyte-colony stimulating factor levels in suction blister patients relationships with disease severity[J] Clin sera of Exp psonati Dermatol,1994, 19(5):383-387.
[41]Pfundt R, Wingens M Bergers M, et al NF-a and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAI kinase-dependent pathway[J]Arch Dermatol Res,2000,292(4):180-187
[42]Fransson J, de-la-Torre B, Hammar H. Psoriatic fibroblasts secrete lower amounts of IL—6 than healthy fibroblasts before and after stimulation with TNF-a [J].Arch Dermatol Res,1999,291(10):538-541
[43]Trembath RC et at. J Rheumatol,1997,24(5):856-859
[44]Balendran N et al. J Invest Dermatol,1999,113(3):322-328
[45]Ohkawara A et al J Rheumatol,1995,22(12):2266-2272
[46]Gladman DD, Farewell VT J Dermatol,1995,22(6):428-433
[47]Gladman DD et al.A rthritis Reum,1998,41(4):588-595
[48]Gonzale S et al. A rthritis Rheum,1999,42(5):1010-1016
[49]Hohler T et al.Br J Dermatol,1996 135(5):738-745
[50]Schmitt GM et al. J Invest Dermatol,1993,100(6):749-752
[51]Jee SH et al.Br.1 Dermatol,1998,139(6):978-983
[52]Jones JL, Berth-Jones J, Fletcher A et al.Assessment of epidermal dendritic cell markers and T-lymphocytes in psoriasis.J Pathol,1994,174(2):77-82
[53]Nickoloff BJ, Wrone-Smith T. Injection of pre-psoriasis skin with CD4+T cells induces Psoriasis. Am J Pathol,1999,155(1):145-158
[54]Paquet P, Pierard GE. Interleukin-6 and the skin [J).Int Arch Allergy Immunol, 1996,109:308
[55]Bonifati C, Trento E, Cordiali-Fei P, et al, Incrcased interleukin-7 concentrations in lesional skin and in the sera of patients with plaque-type psoriasis [J]. C:lin Immunol Immunopathol,1997,83:41
[56]Prens I;, Hegmans J, chin R, et al.Increased expression of interlcukin-4 receptors on psoriatic epidermal cells[Jj Am J pathol,1996,148:1493
[57]Howard M, O Garra A.Biological properties of interleukin-10 [J].Immunol To day,1992 13:198
[58]Leng X, Elias JA.Interleukin-11 inhibits macrophage interleukin-12 producton [J]. J Immunol,1997,159:2161
[59]Fierlbeck G, Rassner G, Muller G. Psoriasis induced at the injection site of recombinant interferon gamma[J]. Arch Dermatol.1990,126(3):351.
[60]王桂芝,刘成玉,纪新强,等.藻酸双醋钠对银屑病病人白细胞流变性及细胞钻附分子表达的影响[[J].青岛大学医学院学报,2000,36(1)：37
[61]Bonifati C, Mussi A, Carducci M, et al.Endothelin-I levels are increased in serand lesional skin extracts of psoriatic patients and correlate with disease severity [J].Acta Derm Venereol (stockh),1998,78:22
[62]lTokura, et al. Arch Dermatol Res,1999,291(7-8):382
[63]Valdimarsson H, et al. Clin Exp Immunol,1997,107(Suppll):21
[64]Valdimarsson H, et al. Immunology Today,1995,16:145
[65]Weissenborn, et al. J Invest Dermatol,1999,113(1):122
[66]Favre M, et al. J Invest Dermatol,1998,110(4).-311
[67]Bonifati C, et al. Clin Exp Dermatol,1994,19:383
[68]Kristensen M, et al. Clin Exp Immunol,1993,94:354
[69]Bonifati C, et al. Clin Exp Dermatol,1994,19:383
[70]Weitzul, et al. Semin Cutan Med Surg,1997,16(3):213
[71]Bunse T, et al. Arch Dermatol Venereol(Stockh),1996,76(1):10
[72]Tsuboi R, et al. Jpn J Med Mycol,1995,36(2):127
[73]Detmar M. Brown LF. Claffey KP. et al. overpression of vascular perinea bility factor/vascular endothelial growth factor and it receptors in psoriasis J Eyp Med、 1994,180:1141-1146
[74]Bhushan M. Mclaughin B.Weiss JB, et al.levels of endothelial cell stimmlatingangiogenesis factor and endothelial growth factor are elevated in psorssis. Br dermatol.1999,141:1054-1060
[75]Farber EM, Bright RP, Nall ML, et al. Psoriasis:a questionaire survery of 2114 patients [J] Arch Dermatol. Farbcr EM, Nicheoloff BJ 1968,18(3):258-259
[76]Recht B, et al. Stress, symmetry and psoriasis:possbile role of neuropeptides[J]J Am Acad Dermato],1986,14(2):305-309