黑腹果蝇DOA蛋白激酶与底物eEF1Bγ和SRm160相互作用的研究
|
摘要
Darkener of apricot(Doa)是果蝇基因组中编码LAMMER激酶的唯一位点。因其在哺乳动物存在4个同源蛋白(CLK1-4),LAMMER激酶也被称为CLK激酶。关于LAMMER激酶的功能了解最清楚的是它可能磷酸化SR和类SR蛋白,通过调控果蝇体细胞性别决定信号通路中关键因子doublesex的选择性剪接,从而控制果蝇的性别分化。本研究确定了eEF1Bγ和SRm160为DOA激酶的磷酸化底物,并进一步研究这两种蛋白与DOA蛋白激酶的相互作用及在其果蝇发育中的作用。扩充了LAMMER激酶参与调控的生理功能。
通过酵母双杂交,发现果蝇eEF1Bγ(翻译延长因子1Bγ)与DOA激酶存在相互作用。关于eEF1Bγ基因的研究主要集中在低等生物,在果蝇及更高等的真核生物中,未见相关研究。果蝇eEF1Bγ蛋白C端的丝氨酸~(294)极为保守,可能是LAMMER激酶的磷酸化位点。进一步研究发现在体外和体内实验中eEF1Bγ都能够被LAMMER激酶磷酸化,并通过点突变的方法确定了该磷酸化位点。本研究通过免疫荧光组化的方法确定该蛋白在果蝇胚胎发育中的表达及分布情况,并在蛹期的细胞核提取物中检测到该蛋白的存在。该位点的无义突变造成果蝇隐性致死,说明eEF1Bγ蛋白在果蝇中担负重要的生理功能。为了进一步揭示eEF1Bγ中DOA磷酸化的作用,我们构建了野生型载体和磷酸化位点被突变的突变载体,结果证实该磷酸化位点的缺失降低了蛋白的活性,因为诱导转化的野生型基因位点表达可以逆转内在的纯合无义等位基因的致死性,而该磷酸化位点突变后,诱导表达的蛋白只能在一定程度上逆转致死性。
在mRNA前体组成型和选择性拼接过程中SRm160都是必不可少的作用因子,另外SRm160还参与mRNA前体3'端加工。SRm160蛋白含有多个可能的LAMMER激酶的作用位点。本研究通过原位杂交和免疫组化的方法,研究了SRm160 mRNA和蛋白质在胚胎中的表达及分布。SRm160基因活性的丧失及高表达对果蝇都具致死性。另外器官特异性的诱导SRm160高表达与RNAi导致多种的器官的发育异常。高表达SRm160导致果蝇复眼结构严重异常和雄性生殖器结构异常或完全缺失雄性生殖器和肛门。而DOA位点的突变抑制高表达在复眼中导致的突变表型,但增强在生殖器中高表达导致的表型,该结果显示在不同器官中,不同的信号通路参与SRm160和DOA的相互作用。此外,Doa突变可以造成雌果蝇出现不同程度的雄性化特征,而SRm160无义突变基因增强Doa突变诱导的这种性别逆转表型。该结果表明SRm160可能也是DOA激酶的底物并参与果蝇体细胞性别决定的信号通路。我们的研究结果表明Doa和SRm160基因之前存在密切的遗传上的相互作用,这说明SRm160是一个DOA激酶的作用底物。为了确切阐明二者间的相互作用机制,还需要进一步通过生物化学和分子生物学的手段进行更深入的研究。
The Darkener of apricot(Doa) is the unique locus encoding LAMMER kinase in Drosophila. LAMMER kinase is also known as CLK for its 4 paralogues(CLK1-4) in mammals.The best studied role of LAMMER kinases is that it phosphorylate the SR and SR-like proteins and subsequently regulate the alternative splicing events in somatic sex-determination pathway in Drosophila.In this study,we identified eEF1Bγand SRm160 as the substrates of DOA kinase,and characterize their roles in development of Drosophila,in order to shed more light on the roles of LAMMER kinase.
Drosophila eEF1Bγwas isolated as a protein interacting with DOA kinase in a yeast two-hybrid screen.It contains a predicted and conserved phosphorylation site(Serine~(294)) for LAMMER kinases in its C-terminal region.The locus encoding eEF1Bγin Drosophila or any other higher eukaryote has never been analyzed,eEF1Bγprotein is phosphorylated in vitro and as well in vivo by DOA,and the phosphorylation site identified via site-directed mutagensis.The protein expression pattern in embryos is investigated via immunocytochemistry and the existence of EF-1γis detected in pupal nuclear fractions.I generated and characterized several EF-1γmutant alleles via excision of a P-element provides,including a recessive lethal null allele.To define further the function of the phosphorylation of EF-1γby DOA,we generated wildtype and mutant constructs expressing a Serine-294-Alanine substitution.The absence of this phosphorylation site reduces the activity of the protein,since the expression of the mutant construct does not rescue the lethality caused by homozygoty of the null allele as well as that of the wildtype.
SRm160 functions as a splicing co-activator,which is required in both constitutive and alternative splicing.It is also involved in pre-mRNA 3'-end processing.SRm160 contains several potential phosphorylation sites for LAMMER kinases.The transcript and protein expression pattern of SRm160 during embryogenesis were performed.Loss of SRm160 activity and its ubiquitous over-expression provoke lethality.Not surprisingly,over-expression and RNA interference for SRm160 with different drivers disturbs the development of multiple organs.RNA interference of SRm160 leads to slightly rough eyes and blistered wings,respectively.Overexpression SRm160 result in extremely rough eyes and abnormal genital structure or males lacking genitalia and analia, respectively.Interestingly,Doa mutations supress the overexpression phenotype in eye,but enhance the phenotype in genitals,indicating different singal pathways are involved in the interaction.In addition,as for the interaction between Doa and SRm160,SRm160 mutant alleles enhance the female-to-male sex transformation phenotype of Doa alleles,further indicating its involvement in somatic sex determination,and its probability as a DOA substrate.Our results to date indicate the strong genetic interactions between Doa and SRm160,suggesting the idea that SRm160 is a substrate of DOA kinase.However,more biochemical and molecular investigations need to be done to elucidate and confirm the mechanism of their interactions.
通过酵母双杂交,发现果蝇eEF1Bγ(翻译延长因子1Bγ)与DOA激酶存在相互作用。关于eEF1Bγ基因的研究主要集中在低等生物,在果蝇及更高等的真核生物中,未见相关研究。果蝇eEF1Bγ蛋白C端的丝氨酸~(294)极为保守,可能是LAMMER激酶的磷酸化位点。进一步研究发现在体外和体内实验中eEF1Bγ都能够被LAMMER激酶磷酸化,并通过点突变的方法确定了该磷酸化位点。本研究通过免疫荧光组化的方法确定该蛋白在果蝇胚胎发育中的表达及分布情况,并在蛹期的细胞核提取物中检测到该蛋白的存在。该位点的无义突变造成果蝇隐性致死,说明eEF1Bγ蛋白在果蝇中担负重要的生理功能。为了进一步揭示eEF1Bγ中DOA磷酸化的作用,我们构建了野生型载体和磷酸化位点被突变的突变载体,结果证实该磷酸化位点的缺失降低了蛋白的活性,因为诱导转化的野生型基因位点表达可以逆转内在的纯合无义等位基因的致死性,而该磷酸化位点突变后,诱导表达的蛋白只能在一定程度上逆转致死性。
在mRNA前体组成型和选择性拼接过程中SRm160都是必不可少的作用因子,另外SRm160还参与mRNA前体3'端加工。SRm160蛋白含有多个可能的LAMMER激酶的作用位点。本研究通过原位杂交和免疫组化的方法,研究了SRm160 mRNA和蛋白质在胚胎中的表达及分布。SRm160基因活性的丧失及高表达对果蝇都具致死性。另外器官特异性的诱导SRm160高表达与RNAi导致多种的器官的发育异常。高表达SRm160导致果蝇复眼结构严重异常和雄性生殖器结构异常或完全缺失雄性生殖器和肛门。而DOA位点的突变抑制高表达在复眼中导致的突变表型,但增强在生殖器中高表达导致的表型,该结果显示在不同器官中,不同的信号通路参与SRm160和DOA的相互作用。此外,Doa突变可以造成雌果蝇出现不同程度的雄性化特征,而SRm160无义突变基因增强Doa突变诱导的这种性别逆转表型。该结果表明SRm160可能也是DOA激酶的底物并参与果蝇体细胞性别决定的信号通路。我们的研究结果表明Doa和SRm160基因之前存在密切的遗传上的相互作用,这说明SRm160是一个DOA激酶的作用底物。为了确切阐明二者间的相互作用机制,还需要进一步通过生物化学和分子生物学的手段进行更深入的研究。
The Darkener of apricot(Doa) is the unique locus encoding LAMMER kinase in Drosophila. LAMMER kinase is also known as CLK for its 4 paralogues(CLK1-4) in mammals.The best studied role of LAMMER kinases is that it phosphorylate the SR and SR-like proteins and subsequently regulate the alternative splicing events in somatic sex-determination pathway in Drosophila.In this study,we identified eEF1Bγand SRm160 as the substrates of DOA kinase,and characterize their roles in development of Drosophila,in order to shed more light on the roles of LAMMER kinase.
Drosophila eEF1Bγwas isolated as a protein interacting with DOA kinase in a yeast two-hybrid screen.It contains a predicted and conserved phosphorylation site(Serine~(294)) for LAMMER kinases in its C-terminal region.The locus encoding eEF1Bγin Drosophila or any other higher eukaryote has never been analyzed,eEF1Bγprotein is phosphorylated in vitro and as well in vivo by DOA,and the phosphorylation site identified via site-directed mutagensis.The protein expression pattern in embryos is investigated via immunocytochemistry and the existence of EF-1γis detected in pupal nuclear fractions.I generated and characterized several EF-1γmutant alleles via excision of a P-element provides,including a recessive lethal null allele.To define further the function of the phosphorylation of EF-1γby DOA,we generated wildtype and mutant constructs expressing a Serine-294-Alanine substitution.The absence of this phosphorylation site reduces the activity of the protein,since the expression of the mutant construct does not rescue the lethality caused by homozygoty of the null allele as well as that of the wildtype.
SRm160 functions as a splicing co-activator,which is required in both constitutive and alternative splicing.It is also involved in pre-mRNA 3'-end processing.SRm160 contains several potential phosphorylation sites for LAMMER kinases.The transcript and protein expression pattern of SRm160 during embryogenesis were performed.Loss of SRm160 activity and its ubiquitous over-expression provoke lethality.Not surprisingly,over-expression and RNA interference for SRm160 with different drivers disturbs the development of multiple organs.RNA interference of SRm160 leads to slightly rough eyes and blistered wings,respectively.Overexpression SRm160 result in extremely rough eyes and abnormal genital structure or males lacking genitalia and analia, respectively.Interestingly,Doa mutations supress the overexpression phenotype in eye,but enhance the phenotype in genitals,indicating different singal pathways are involved in the interaction.In addition,as for the interaction between Doa and SRm160,SRm160 mutant alleles enhance the female-to-male sex transformation phenotype of Doa alleles,further indicating its involvement in somatic sex determination,and its probability as a DOA substrate.Our results to date indicate the strong genetic interactions between Doa and SRm160,suggesting the idea that SRm160 is a substrate of DOA kinase.However,more biochemical and molecular investigations need to be done to elucidate and confirm the mechanism of their interactions.
引文
Al-Maghrebi, M., H. Brule, M. Padkina, C. Allen, W. M. Holmes et al, 2002 The 3' untranslated region of human Vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1. Nucleic Acids Res 30: 5017-5028.
Alber, T., 1992 Structure of the leucine zipper. Curr Opin Genet Dev 2: 205-210.
Amons, R., M. A. Guerrucci, R. H. Karssies, J. Morales, P. Cormier et al, 1994 The leucine-zipper in elongation factor EF-1 delta, a guanine-nucleotide exchange protein, is conserved in Artemia and Xenopus. Biochim Biophys Acta 1218: 346-350.
Amrein, H., M. Gorman and R. Nothiger, 1988 The sex-determining gene tra2 of Drosophila encodes a putative RNA binding protein. Cell 55: 1025-1035.
An, W., S. Cho, H. Ishii and P. C. Wensink, 1996 Sex-specific and non-sex-specific oligomerization domains in both of the doublesex transcription factors from Drosophila melanogaster. Mol Cell Biol 16: 3106-3 111.
Andersen, G. R., P. Nissen and J. Nyborg, 2003 Elongation factors in protein biosynthesis. Trends Biochem Sci 28: 434-441.
Arbeitman, M. N., E. E. M. Furlong, F. Imam, E. Johnson, B. H. Null et al, 2002 Gene expression during the life cycle of Drosophila melanogaster. Science 297: 2270-2275.
Arikawa, K., J. L. Hicks and D. S. Williams, 1990 Identification of actin filaments in the rhabdomeral microvilli of Drosophila photoreceptors. J Cell Biol 110: 1993-1998.
Ashburner, M., 1989 Drosophila- a laboratory handbook. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman et al. (Editors), 1989 Curr. Prot. Molec. Biol Greene/Wiley Publishing, N.Y.
Avila, F. W., and J. W. Erickson, 2007 Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Curr Biol 17: 643-648.
Baker, B. S., 1989 Sex in flies: the splice of life. Nature 340: 521-524.
Baker, N. E., S. Yu and D. Han, 1996 Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol 6: 1290-1301.
Baker, N. E., and S. Y. Yu, 1998 The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose. Mech Dev 74: 3-14.
Baker, N. E., and S. Y. Yu, 2001 The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 104: 699-708.
Baker, N. E., and A. E. Zitron, 1995 Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous. Mech Dev 49: 173-189.
Barbash, D. A., and T. W. Cline, 1995 Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster. Genetics 141: 1451-1471.
Basler, K., and E. Hafen, 1989 Dynamics of Drosophila eye development and temporal requirements of sevenless expression. Development 107: 723-731.
Beausoleil, S. A., M. Jedrychowski, D. Schwartz, J. E. Elias, J. Villen et al, 2004 Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101:12130-12135.
Bec, G., P. Kerjan and J. P. Waller, 1994 Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation.J Biol Chem 269:2086-2092.
BECKER,W.,H.KENTRUP,J.HEUKELBACH and H.G.JOOST,1996 cDNA cloning and characterization of rat Clk3,a LAMMER kinase predominantly expressed in testis.Biochem.Biophys.Acta 1312:63-67.
BELL,L.R.,J.I.HORABIN,P.SCHEDL and T.W.CLINE,1991 Positive autoregulation of sexlethal by alternative splicing maintains the female determined state in Drosophila.Cell 65:229-239.
BELL,L.R.,E.M.MAINE,P.SCHEDL and T.W.CLNE,1988 Sex-lethal,a Drosophila sexdetermination switch gene,exhibits sex-specific RNA splicing and sequence similarity to RNA-binding proteins.Cell 55:1037-1046.
BELLE,R.,J.DERANCOURT,R.POULHE,J.-P.CAPONY,R.OZON et al.,1989 A purified complex from Xenopus oocytes contains a P-47 protein,an in vivo substrate of MPF,and a p30 protein respectively homologous to elongation factors EF1γ and EF1B.FEBS 255:101-104.
BELOTE,J.M.,M.MCKEOWN,R.T.BOGGS,R.OHKAWA and B.A.SOSNOWSKI,1989Molecular genetics of transformer,a genetic switch controlling sexual differentiation in Drosophila.Dev Genet 10:143-154.
BEN-DAVID,Y.,K.LETWIN,L.TANNOCK,A.BERNSTEIN and T.PAWSON,1991 A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.EMBO J.10:317-325.
BENDER,J.,and G.R.FINK,1994 AFC1,a LAMMER kinase from Arabidopsis thaliana,activates STE12-dependent processes in yeast.Proc.Natl.Acad.Sci.USA 91:12105-12109.
BERGET,S.M.,and P.A.SHARP,,1977 A spliced sequence at the 5'-terminus of adenovirus late mRNA.Brookhaven Symp Biol:332-344.
BINGHAM,P.M.,and B.H.JUDD,1981 A copy of the copia transposable element is very tightly linked to the w~a allele at the white locus of D.melanogaster.Cell 25:705-711.
BIRNEY,E.,S.KUMAR and A.R.KRAINER,1993 Analysis of the RNA-recognition motif and RS and RGG domains:conservation in metazoan pre-mRNA splicing factors.Nucleic Acids Res 21:5803-5816.
BLACK,D.L.,2003 Mechanisms of alternative pre-messenger RNA splicing.Annu Rev Biochem 72:291-336.
BLACKMAN,R.K.,M.SANICOLA,L.A.RAFTERY,T.GILLEVET and W.M.GELBART,1991An extensive 3' cis-regulatory region directs the imaginal disk expression of decapentaplegic,a member of the TGF-beta family in Drosophila.Development 111:657-666.
BLANCHARD,J.M.,J.WEBER,W.JELINEK and J.E.DARNELL,1978 In vitro RNA-RNA splicing in adenovirus 2 mRNA formation.Proc Natl Acad Sci U S A 75:5344-5348.
BLENCOWE,B.J.,2000 Exonic splicing enhancers:mechanism of action,diversity and role in human genetic diseases.Trends Biochem Sci 25:106-110.
BLENCOWE,B.J.,G.BAUREN,A.G.ELDRIDGE,R.ISSNER,J.A.NICKERSON et al.,2000 The SRm160/300 splicing coactivator subunits.RNA 6:111-120.
BLENCOWE,B.J.,J.A.BOWMAN,S.MCCRACKEN and E.ROSONINA,1999 SR-related proteins and the processing of messenger RNA precursors.Biochem Cell Biol.77:277-291.
BLENCOWE,B.J.,R.ISSNER,J.A.NICKERSON and P.A.SHARP,1998 A coactivator of pre-mRNA splicing.Genes Dev.12:996-1009.
BLENCOWE,B.J.,and C.A.OUZOUNIS,1999 The PWI motif:a new protein domain in splicing factors.Trends Biochem Sci 24:179-180.175_00001387.
Bodenmiller, B., D. Campbell, B. Gerrits, H. Lam, M. Jovanovic et al, 2008 PhosphoPep--a database of protein phosphorylation sites in model organisms. Nat Biotechnol 26: 1339-1340.
Booggs, R. T., P. Gregor, S. Idriss, J. M. Belote and M. McKeown, 1987 Regulation of sexual differentiation via alternative processing of RNA from the transformer gene. Cell 50: 739-747.
Boucher, L., C. A. Ouzounis, A. J. Enright and B. J. Blencowe, 2001 A genome-wide survey of RS domain proteins. Rna 7: 1693-1701.
Brand, A., and N. Perrimon, 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
Breathnach, R., C. Benoist, K. O'Hare, F. Gannon and P. Chambon, 1978 Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A 75: 4853-4857.
Brennan, C. A., and K. Moses, 2000 Determination of Drosophila photoreceptors: timing is everything. Cell Mol Life Sci 57: 195-214.
Bridges, C. B., 1921 Triploid Intersexes in Drosophila Melanogaster. Science 54: 252-254.
Brody, T. B., 1995 The Interactive Fly pp. in Genes involved in tissue and organ development.
Brook, W. J., F. J. Diaz-Benjumea and S. M. Cohen, 1996 Organizing spatial pattern in limb development. Annu Rev Cell Dev Biol 12:161-180.
Brown, K. E., and M. Freeman, 2003 Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development 130: 5401-5412.
Brown, N. L., C. A. Sattler, S. W. Paddock and S. B. Carroll, 1995 Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye. Cell 80: 879-887.
Burtis, K. C., and B. S. Baker, 1989 Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex- specific polypeptides. Cell 56: 997-1010.
Caceres, J. F., G. R. Screaton and A. R. Krainer, 1998 A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev. 12: 55-66.
Cagan, R. L., and D. F. Ready, 1989 The emergence of order in the Drosophila pupal retina. Develop. Biol. 136: 346-362.
Campos-Ortega, J. A., and V. Hartenstein, 1997 The embryonic development of Drosophila melanogaster. Springer, Berlin.
Cao, W., S. F. Jamison and M. A. Garcia-Blanco, 1997 Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. Rna 3: 1456-1467.
Caputi, M., G. Casari, S. Guenzi, R. Tagliabue, A. Sidoli et al, 1994 A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon. Nucleic Acids Res 22: 1018-1022.
Carr-Schmid, A., L. Valente, V. I. Loik, T. Williams, L. M. Starita et al, 1999 Mutations in elongation factor 1beta, a guanine nucleotide exchange factor, enhance translational fidelity. Mol Cell Biol 19: 5257-5266.
Carvalho, M. D., J. F. Carvalho and W. C. Merrick, 1984a Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes. Arch Biochem Biophys 234: 603-611.
Carvalho, M. G., J. F. Carvalho and W. C. Merrick, 1984b Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes. Arch. Biochem. Biophys. 234:603-611.
Casanova, J., E. Sanchez-Herrero and G. Morata, 1986 Identification and characterization of a parasegment specific regulatory element of the abdominal-B gene of Drosophila. Cell 47: 627-636.
Casares, F., SAnchez, L., Guerrero, I. and Sanchez-Herrero, E., 1997 The genital disc of Drosophila melanogaster. I. Segmental and compartmental organization. Dev Genes Evol 207:216-228.
Celniker, S. E., D. J. Keelan and E. B. Lewis, 1989 The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain.. Genes Dev 3: 1424-1436.
Chang, H. Y., and D. F. Ready, 2000 Rescue of photoreceptor degeneration in rhodopsin- null Drosophila mutants by activated Racl. Science 290: 1978-1980.
Chang, Y. F., J. S. Imam and M. F. Wilkinson, 2007 The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76: 51-74.
Chang, Y. W., and J. A. Traugh, 1997 Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation. J Biol Chem 272: 28252-28257.
Chang, Y. W., and J. A. Traugh, 1998 Insulin stimulation of phosphorylation of elongation factor 1 (eEF-1) enhances elongation activity. Eur J Biochem 251: 201-207.
Chen, C. J., and J. A. Traugh, 1995 Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II. Biochim Biophys Acta 1264:303-311.
Chen, E. H., and B. S. Baker, 1997 Compartmental organization of the Drosophila genital imaginal discs. Development 124: 205-218.
Cheng, C., and P. A. Sharp, 2006 Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol 26: 362-370.
Chew, S. L., H. X. Liu, A. Mayeda and A. R. Krainer, 1999 Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A 96: 10655-10660.
Choi, K. W., and S. Benzer, 1994 Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene. Cell 78:125-136.
Chou, T. B., Z. Zachar and P. M. Bingham, 1987 Developmental expression of a regulatory gene is programmed at the level of splicing. Embo J 6: 4095-4104.
Chou, Y. H., and C. T. Chien, 2002 Scabrous controls ommatidial rotation in the Drosophila compound eye. Dev Cell 3: 839-850.
Chow, L. T., R. E. Gelinas, T. R. Broker and R. J. Roberts, 1977 An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell 12:1-8.
Cline, T. W., 1988 Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states. Genetics 119: 829-862.
Colwill, K., L. L. Feng, J. M. Yeakley, G. D. Gish, J. F. Caceres et al, 1996a SRPK1 and Clk/STY protein kinases show distinct substrate specificities for Serine/Arginine- rich splicing factors. J. Biol.Chem. 271: 24569-24575.
Colwill, K., T. Pawson, B. Andrews, J. Prasad, J. L. Manley et al, 1996b The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. Embo J 15: 265-275.
Colwill, K., T. Pawson, B. Andrews, J. Prasad, J. L. Manley et al, 1996c The Clk/STY protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 15:265-275.
Cooper, M. T., and S. J. Bray, 2000 R7 photoreceptor specification requires Notch activity. Curr Biol 10: 1507-1510.
Cormier, P., H. B. Osborne, J. Morales, T. Bassez, R. Poule et al, 1991 Molecular cloning of
Xenopus elongation factor 1γ, major M-phase promoting factor substrate. Nuc. Acids Res. 19: 6644.
Cox, R. A., 1968 The use of guanidium chloride in the isolation of nucleic acids. Meth. Enz. 12: 120-129.
Cuccurese, M., G. Russo, A. Russo and C. Pietropaolo, 2005 Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression. Nucleic Acids Res 33: 5965-5977.
Curtiss, J., and M. Mlodzik, 2000 Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development 127: 1325-1336.
Custodio, N., C. Carvalho, I. Condado, M. Antoniou, B. J. Blencowe et al, 2004 In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei. Rna 10: 622-633.
Das, P., L. L. Maduzia, H. Wang, A. L. Finelli, S. H. Cho et al, 1998 The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125: 1519-1528.
Dasmahapatra, B., L. Skogerson and K. Chakraburtty, 1981 Protein synthesis in yeast II. Purification and properties of elongation factor 1 from Saccharomyces cerevisiae. J. Biol. Chem. 256: 10005-10011.
Dauksaite, V., and G. Akusjarvi, 2004 The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection. Biochem J 381: 343-350.
Dauwalder, B., S. Tsujimoto, J. Moss and W. Mattox, 2002 The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. Genes Dev 16: 2879-2892.
Del Gatto, F., and R. Breathnach, 1995 Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol 15: 4825-4834.
Dokucu, M. E., S. L. Zipursky and R. L. Cagan, 1996 Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina. Development 122:4139-4147.
Dominguez, M., 1999 Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development. Development 126: 2345-2353.
Dominguez, M., and J. F. de Celis, 1998 A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396: 276-278.
Dominguez, M., and E. Hafen, 1997 Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye. Genes Dev 11: 3254-3264.
Dominguez, M., J. D. Wasserman and M. Freeman, 1998 Multiple functions of the EGF receptor in Drosophila eye development. Curr Biol 8: 1039-1048.
Dorsett, D., 1990 Potentiation of a polyadenylation site by a downstream protein-DNA interaction. Proc. Natl. Acad. Sci. USA 87:4373-4377.
Du, C., M. E. McGuffin, B. Dauwalder, L. Rabinow and W. Mattox, 1998 Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila. Molecular Cell 2: 741-750.
Duffy, J. B., and J. P. Gergen, 1991 The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex- determining gene Sex-lethal. Genes Dev 5: 2176-2187.
DUNCAN,P.I.,D.F.STOJDL,R.M.MARIUS and J.C.BELL,1997 In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.Mol.Cell.Biol.17:5996-6001.
DUNCAN,P.I.,D.F.STOJDL,R.M.MAGUS,K.H.SCHEIT and J.C.BELL,1998 The Clk2and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.Exp.Cell Res.241:300-308.
DURFEE,T.,K.BECHERER,P.L.CHEN,S.H.YEH,Y.YANG et al.,1993 The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.Genes Develop.7:555-569.
EDMONDS,M.,M.H.VAUGHAN,JR.and H:NAKAZATO,1971 Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells:possible evidence for a precursor relationship.Proc Natl Acad Sci U S A 68:1336-1340.
EJIRI,S.,2002 Moonlighting functions of polypeptide elongation factor 1:from actin bundling to zinc finger protein R1-associated nuclear localization.Biosci Biotechnol Biochem 66:1-21.
EJIRI,S.,N.EBATA,R.KAWAMURA and T.KATSUMATA,1983 Occurrence of four subunits in high molecular weight forms of polypeptide chain elongation factor 1 from wheat embryo.J Biochem 94:319-322.
ELDRIDGE,A.G.,Y.LI,P.A.SHARP and B.J.BLENCOWE,1999 The SRm160/300 splicing coactivator is required for exon-enhancer function.Proc Natl Acad Sci 96:6125-6130.
EPPER,F.,and R.NOTHIGER,1982 Genetic and developmental evidence for a repressed genital primordium in Drosophila melanogaster.Dev Biol 94:163-175.
ESTES,P.A.,L.N.KEYES and P.SCHEDL,1995 Multiple response elements in the Sex-lethal early promoter ensure its female-specific expression pattern.Mol Cell Biol 15:904-917.
ESTRADA,B.,F.CASARES and E.SANCHEZ-HERRERO,2003 Development of the genitalia in Drosophila melanogaster.Differentiation 71:299-310.
ESTRADA,B.,and E.SANCHEZ-HERRERO,2001 The Hox gene Abdominal-B antagonizes appendage development in the genital disc of Drosophila.Development 128:331-339.
FEHON,R.G.,K.JOHANSEN,I.REBAY and S.ARTAVANIS-TSAKONAS,1991 Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila:implications for notch function.J Cell Biol 113:657-669.
FISCHER-VIZE,J.A.,G.M.RUBIN and R.LEHMANN,1992 The fat facets gene is required for Drosophila eye and embryo development.Development 116:985-1000.
FLAHERTY,S.M.,P.FORTES,E.IZAURRALDE,I.W.MATTAJ and G.M.GrLMARTIN,1997Participation of the nuclear cap binding complex in pre-mRNA 3' processing.Proc Natl Acad Sci U S A94:11893-11898.
FOLEY,E.,and P.H.O'FARRELL,2004a Functional dissection of an innate immune response by a genome-wide RNAi screen.PLos Biology 2:1091-1106.
FOLEY,E.,and P.H.O'FARRELL,2004b Functional dissection of an innate immune response by a genome-wide RNAi screen.PLoS Biol 2:E203.
FORCH,P.,and J.VALCARCEL,2003 Splicing regulation in Drosophila sex determination.Prog Mol Subcell Biol 31:127-151.
FORTINI,M.E.,I.REBAY,L.A.CARON and S.ARTAVANIS-TSAKONAS,1993 An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.Nature 365:555-557.
FRANKFORT,B.J.,and G.MARDON,2002 R8 development in the Drosophila eye:a paradigm for neural selection and differentiation.Development 129:1295-1306.
FREELAND,D.E.,and D.T.KUHN,1996 Expression patterns of developmental genes reveal segment and parasegment organization ofD.melanogaster genital discs.Mech Dev 56:61-72.
FREEMAN,M.,1996 Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.Cell 87:651-660.
FREEMAN,M.,1997 Cell determination strategies in the Drosophila eye.Development 124:261-270.
FREEMAN,M.,C.KLAMBT,C.S.GOODMAN and G.M.RUBIN,1992 The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.Cell 69:963-975.
FRENDEWEY,D.,and W.KELLER,1985 Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences.Cell 42:355-367.
Fu,X.D.,1995 The superfamily of arginine/serine-rich splicing factors.Rna 1:663-680.
FU,X.D.,and T.MANIATIS,1992 The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3'splice site.Proc Natl Acad Sci U S A 89:1725-1729.
GAENGEL,K.,and M.MLODZIK,2003 Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.Development 130:5413-5423.
GATFIELD,D.,and E.IZAURRALDE,2002 REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export.J.Cell Biol.159:579-588.
GE,H.,and J.L.MANLEY,1990 A protein factor,ASF,controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro.Cell 62:25-34.
GELLON,G.,and W.MCGINNIS,1998 Shaping animal body plans in development and evolution by modulation of Hox expression patterns.Bioessays 20:116-125.
GILBERT,W.,and C.GUTHRIE,2004 The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA.Mol Cell 13:201-212.
GILLEN,C.M.,Y.GAO,M.M.NIEHAUS-SAUTER,M.R.WYLDE and M.G.WHEATLY,2008Elongation factor 1Bgamma(eEF1Bgamma) expression during the molting cycle and cold acclimation in the crayfish Procambarus clarkii.Comp Biochem Physiol B Biochem Mol Biol.150:170-176.
GIOT,L.,J.S.BADER,C.BROUWER,A.CHAUDHURI,B.KUANG et al.,2003 A protein interaction map of Drosophila melanogaster.Science 302:1727-1736.
GOLEMBO,M.,R.SCHWEITZER,M.FREEMAN and B.Z.SHILO,1996 Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.Development 122:223-230.
GORSKI,S.M.,S.CHITTARANJAN,E.D.PLEASANCE,J.D.FREEMAN,C.L.ANDERSON et al.,2003a A SAGE approach to discovery of genes involved in autophagic cell death.Curr Biol 13:358-363.
GORSKI,S.M.,S.CHITTARANJAN,E.D.PLEASANCE,J.D.FREEMAN,C.L.ANDERSON et al.,2003b A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death.Curr Biol 13:358-363.
GRABOWSKI,P.J.,1998 Splicing regulation in neurons:Tinkering with cell-specific control.Cell 92:709-712.
GRABOWSKI,P.J.,and D.L.BLACK,2001 Alternative RNA splicing in the nervous system.Progress Neurobiology 65:289-308.
GRABOWSKI,P.J,S.R.SEILER and P.A.SHARP,1985 A multicomponent complex is involved in the splicing of messenger RNA precursors.Cell 42:345-353.
GRAVELY,B.R.,2000 Sorting out the complexity of SR proteins.RNA 6:1197-1211.
GRAVELY,B.R.,2001 Alternative splicing:increasing diversity in the proteomic world.Trends Genetics 17:100-107.
GUI,J.F.,W.S.LANE and X.D.FU,1994 A serine kinase regulates intracellular localization of splicing factors in the cell cycle.Nature 369:678-682.
HACHET,O.,and A.EPHRUSSI,2001 Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.Curr Biol 11:1666-1674.
HACKER,S.,and H.KREBBER,2004 Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins.J Biol Chem 279:5049-5052.
HAFEN,E.,K.BASLER,J.E.EDSTROEM and G.M.RUNIN,1987 Sevenless,a cell-specific homeotic gene of Drosophila,encodes a putative transmembrane receptor with a tyrosine kinase domain.Science 236:55-63.
HARRISON,D.A.,2007 Sex determination:controlling the master.Curr Biol 17:R328-330.
HARTENSTEIN,V.,JAN,Y.N.,1992 Studying Drosophila embryogenesis with P-lacZ enhancer trap lines.Rouxs Arch Dev Biol 201:194-220.
HARTMUTH,K.,H.URLAUB,H.P.VORNLOCHER,C.L.WILL,M.GENTZEL et al.,2002Protein composition of human prespliceosomes isolated by a tobramycin affinityselection method.Proc Natl Acad Sci U S A 99:16719-16724.
HEBERLEIN,U.,T.WOLFF and G.M.RUBIN,1993 The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina.Cell 75:913-926.
HEINRICHS,V.,and B.S.BAKER,1995 The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences.EMBO J.14:3987-4000.
HENRIK MOLINA,D.M.H.,NING TANG,SURESH MATHIVANAN AND AKHILESH PANDEY,2007Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.Proc Natl Acad Sci 104:2199-2204.
HIROSE,Y.,and J.L.MANLEY,2000 RNA polymerase Ⅱ and the integration of nuclear events.Genes Dev 14:1415-1429.
HOFMANN,M.,W.RUDY,U.GUNTHERT,S.G.ZIMMER,V.ZAWADZKI et al.,1993 A link between ras and metastatic behavior of tumor cells:ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells.Cancer Res 53:1516-1521.
HOSHIJIMA,K.,A.KOHYAMA,I.WATAKABE,K.INOUE,H.SAKAMOTO et al.,1995Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins.Nucleic Acids Res 23:3441-3448.
HOWELL,B.W.,D.E.H.AFAR,J.LEW,E.M.J.DOUVILLE,P.L.E.ICELEY et al.,1991 STY,a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.Mol.Cell.Biol.11:568-572.
HSIEH,S.L.,and R.D.CAMPBELL,1991 Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase.Biochem J 278(Pt 3):809-816.
HUANG,Y.,and J.A.FISCHER-VIZE,1996 Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease.Development 122:3207-3216.
HUANG,Y.,R.GATTONI,J.STEVENIN and J.A.STEITZ,2003 SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.Mol Cell 11:837-843.
HUANG,Y.,and J.A.STEITZ,2001 Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.Mol Cell 7:899-905.
HUANG,Y.,T.A.YARIO and J.A.STEITZ,2004 A molecular link between SR protein dephosphorylation and mRNA export.Proc Natl Acad Sci U S A 101:9666-9670.
Hughes, J. R., A. M. Meireles, K. H. Fisher, A. Garcia, P. R. Antrobus et al, 2008a A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis. PLos Biology 6: 785-795.
Hughes, J. R., A. M. Meireles, K. H. Fisher, A. Garcia, P. R. Antrobus et al, 2008b A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol 6: e98.
Hughes, S. C., and R. G. Fehon, 2007 Understanding ERM proteins-the awesome power of genetics finally brought to bear. Curr Opin Cell Biol 19: 51-56.
Iborra, F. J., D. A. Jackson and P. R. Cook, 1998 The path of transcripts from extra- nucleolar synthetic sites to nuclear pores: transcripts in transit are concentrated in discrete structures containing SR proteins. J Cell Sci 111(Pt 15): 2269-2282.
Isaksson, A., F. A. Peverali, L. Kockel, M. Mlodzik and D. Bohmann, 1997 The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development. Mech Dev 68: 59-67.
James, P., J. Halladay and E. A. Craig, 1996 Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.
Jamison, S. F., Z. Pasman, J. Wang, C. Will, R. Luhrmann et al, 1995 U1 snRNP- ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res 23: 3260-3267.
Janssen, G. M., and W. Moller, 1988a Elongation factor 1 beta gamma from Artemia. Purification and properties of its subunits. Eur J Biochem 171: 119-129.
Janssen, G. M. C., and W. Moller, 1988b Elongation factor 1βγ from Artemia: purification and properties of its subunits. Eur. J. Biochem. 171: 119-129.
Janssen, G. M. C., J. Morales, A. Schipper, J.-C. Labbe, O. Mulner-Lorillon et al, 1991 A major substrate of maturation promoting factor identified as elongation factor 1Bγδ in Xenopus laevis. J. Biol. Chem. 266: 14885-14888.
Jarman, A. P., E. H. Grell, L. Ackerman, L. Y. Jan and Y. N. Jan, 1994 Atonal is the proneural gene for Drosophila photoreceptors. Nature 369: 398-400.
Jarman, A. P., Y. Sun, L. Y. Jan and Y. N. Jan, 1995 Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121: 2019-2030.
Jeppesen, M. G., P. Ortiz, W. Shepard, T. G. Kinzy, J. Nyborg et al, 2003 The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. J Biol Chem 278:47190-47198.
Johnson, K. W., and K. A. Smith, 1991 Molecular cloning of a novel human cdc2/CDC28- like protein kinase. J. Biol. Chem. 266: 3402-3407.
Jurica, M. S., and M. J. Moore, 2003 Pre-mRNA splicing: awash in a sea of proteins. Mol Cell 12: 5-14.
Kambouris, N. G., D. J. Burke and C. E. Creutz, 1993 Cloning and genetic characterization of a calcium- and phospholipid-binding protein from Saccharomyces cerevisiae that is homologous to translation elongation factor-1 gamma. Yeast 9: 151- 163.
Kamiie, K., Y. Nomura, S. Kobayashi, H. Taira, K. Kobayashi et al, 2002 Cloning and expression of Bombyx mori silk gland elongation factor 1gamma in Escherichia coli. Biosci Biotechnol Biochem 66: 558-565.
Kamiie, K., H. Taira, K. Kobayashi, T. Yamashita, S. Kidou et al, 1999 Expression of elongation factor 1 beta' in Escherichia coli and its interaction with elongation factor 1 alpha from silk gland. Biosci Biotechnol Biochem 63: 666-671.
KAMIIE,K.,T.YAMASHITA,H.TAIP,A,S.KIDOU and S.EJIRI,2003 Interaction between elongation factors 1beta and 1gamma from Bombyx mori silk gland.Biosci Biotechnol Biochem 67:1522-1529.
KARAGIOSIS,S.A.,and D.F.READY,2004 Moesin contributes an essential structural role in Drosophila photoreceptor morphogenesis.Development 131:725-732.
KARCH,F.,B.WEIFFENBACH,M.PEIFER,W.BENDER,I.DUNCAN et al.,1985 The abdominal region of the bithorax complex.Cell 43:81-96.
KATAOKA,N.,M.D.DIEM,V.N.KIM,J.YONG and G.DREYFUSS,2001 Magoh,a human homolog of Drosophila mago nashi protein,is a component of the splicing-dependent exon-exon junction complex.EMBO J.20:6424-6433.
KAUFMAN,T.C.,R.LEWIS and B.WAKIMOTO,1980 Cytogenetic Analysis of Chromosome 3in DROSOPHILA MELANOGASTER:The Homoeotic Gene Complex in Polytene Chromosome Interval 84a-B.Genetics 94:115-133.
KEISMAN,E.L.,and B.S.BAKER,2001 The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sexspecifically in the genital imaginal disc.Development 128:1643-1656.
KEISMAN,E.L.,A.E.CHRISTIANSEN and B.S.BAKER,2001 The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc.Dev Cell 1:215-225.
KHOURY,G.,P.GRUSS,R.DHAR and C.J.LAI,1979 Processing and expression of early SV40 mRNA:a role for RNA conformation in splicing.Cell 18:85-92.
KIM,S.,J.KELLNER,C.H.LEE and P.A.COULOMBE,2007 Interaction between the keratin cytoskeleton and eEF1Bg affects protein synthesis in epithelial cells.Nature Struct.Molec.Biol.14:982-983.
KIM,V.N.,and G,DREYFUS,2001 Nuclear mRNA binding proteins couple pre-mRNA splicing and post-splicing events.Mol Cells 12:1-10.
KIM,V.N.,J.YONG,N.KATAOKA,L.ABEL,M.D.DIEM et al.,2001 The Y14 protein communicates to the cytoplasm the position of exon-exon junctions.EMBO J.20:2062-2068.
KIMBLE,J.,and P.SIMPSON,1997 The LIN-12/Notch signaling pathway and its regulation.Annu Rev Cell Dev Biol 13:333-361.
LINZY,T.G.,T.L.RtPMASTER and J.L.WOOLFORD,JR.,1994 Multiple genes encode the translation elongation factor EF-1 gamma in Saccharomyces cerevisiae.Nucleic Acids Res 22:2703-2707.
KNUST,E.,2007 Photoreceptor morphogenesis and retinal degeneration:lessons from Drosophila.Curr Opin Neurobiol 17:541-547.
KOBAYASHI,S.,S.KIDOU and S.EJIRI,2001 Detection and characterization of glutathione S-transferase activity in rice EF-1betabeta'gamma and EF-1gamma expressed in Escherichia coli.Biochem Biophys Res Commun 288:509-514.
KOHTZ,J.D.,S.F.JAMISON,C.L.WILL,P.ZUO,R.LUHRMANN et al.,1994 Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.Nature 368:119-124.
KONARSKA,M.M.,and P.A.SHAPP,1987 Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes.Cell 49:763-774.
KONIG,H.,N.MATTER,R.BADER,W.THIELE and F.MULLER,2007 Splicing segregation:the minor spliceosome acts outside the nucleus and controls cell proliferation.Cell 131:718-729.
KONIG,H.,H.PONTA and P.HERRLICH,1998 Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator.EMBO J.17:2904-2913.
KOONIN,E.V.,A.R.MUSHEGIAN,R.L.TATUSOV,S.F.ALTSCHUL,S.H.BRYANT et al.,1994 Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse,ancient protein superfamily using motif search and structural modeling.Protein Sci 3:2045-2054.
KOPP,A.,I.DUNCAN,D.GODT and S.B.CARROLL,2000 Genetic control and evolution of sexually dimorphic characters in Drosophila.Nature 408:553-559.
KPEBE,A.,and L.RABINOW,2008a Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase,genesis 46:132-143.
KPEBE,A.,and L.RABINOW,2008b Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase.Genesis 46:132-143.
KPEBE,A.,and L.RABINOW,2008c Dissection of darkener of apricot kinase isoform functions in Drosophila.Genetics 179:1973-1987.
KPEBE,A.,and L.RABINOW,2008d Dissection of DOA kinase isoform functions in Drosophila.Genetics 179:1973-1987.
K.RAINER,A.R.,G.C.CONWAY and D.KOZAK,1990 Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.Genes Dev 4:1158-1171.
KRAMER,H.,R.L.CAGAN and S.L.ZIPURSKY,1991 Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.Nature 352:207-212.
KRAMER,S.G.,T.M.JINKS,P.SCHEDL and J.P.GERGEN,1999 Direct activation of Sexlethal transcription by the Drosophila runt protein.Development 126:191-200.
KUHN,D.T.,J.A.MACK,C.DUAN and G.PACKERT,1993 Tumorous-head(tub-1;tuh-3)modulates Abd-B bithorax-complex functions in Drosophila melanogaster.Genetics 133:593-604.
KUMAR,J.P.,and D.F.READY,1995 Rhodopsin plays an essential structural role in Drosophila photoreceptor development.Development 121:4359-4370.
KUMAR,J.P.,M.TIO,F.HSIUNG,S.AKOPYAN,L.GABAY et al.,1998 Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.Development 125:3875-3885.
KUZIORA,M.A.,and W.MCGINNIS,1988 Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions.Embo J 7:3233-3244.
KWIATKOWSKI,A.V.,C.C.GARNER,W.J.NELSON and F.B.GERTLER,2009 Cell autonomous defects in cortical development revealed by two-color chimera analysis.Mol Cell Neurosci.
LANKES,W.T.,and H.FURTHMAYR,1991 Moesin:a member of the protein 4.1-talin-ezrin family of proteins.Proc Natl Acad Sci U S A 88:8297-8301.
LAWRENCE,P.A.,and G.STRUHL,1996 Morphogens,compartments,and pattern:lessons from drosophila? Cell 85:951-961.
LE HIR,H.,and G.R.ANDERSEN,2008 Structural insights into the exon junction complex.Curr Opin Struct Biol 18:112-119.
LE SOURD,F.,S.BOULBEN,R.LE BOUFFANT,P.CORMIER,J.MORALES et al.,2006a eEF1B:At the dawn of the 21st century.Biochim Biophys Acta.1759:13-31.
LE SOURD,F.,S.BOULBEN,R.LE BOUFFANT,P.CORMIER,J.MORALES et al.,2006b eEF1B:At the dawn of the 21st century.Biochim Biophys Acta 1759:13-31.
LECUIT,T.,and S.M.COHEN,1997 Proximal-distal axis formation in the Drosophila leg.Nature 388:139-145.
LEE,C.Y.,E.A.CLOUGH,P.YELLON,T.M.TESLOVICH,D.A.STEPHAN et al.,2003Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila.Curr Biol 13:350-357.
LEE,J.D.,and J.E.TREISMAN,2001 The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc.Development 128:1519-1529.
LEE,K.,C.DU,M.HORN and L.RABINOW,1996 Activity and autophosphorylation of LAMMER protein kinases.J.Biol.Chem.271:27299-27303.
LEHIR,H.,D.GATFIELD,E.IZAURRALDE and M.J.MOORE,2001 The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.EMBO J 20:4987-4897.
LEHIR,H.,E.IZAURRALDE,L.E.MAQUAT and M.J.MooRE,2000a The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.EMBO J.19:6860-6869.
LEHIR,H.,M.J.MOORE and L.E.MAQUAT,2000b Pre-mRNA splicing alters mRNP composition:evidence for stable association of proteins at exon-exon junctions.Genes Dev.14:1098-1108.
LERNER,M.R.,J.A.BOYLE,S.M.MOUNT,S.L.WOLIN and J.A.STEITZ,1980 Are snRNPs involved in splicing? Nature 283:220-224.
LEW,Y.,D.V.JONES,W.M.MARS,D.EVANS,D.BYRD et al.,1992 Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer.Pancreas 7:144-152.
LEWIS,B.P.,R.E.GREEN and S.E.BRENNER,2003 Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans.Proc Natl Acad Sci U S A 100:189-192.
LI,B.X.,A.K.SATOH and D.F.READY,2007 Myosin V,Rab11,and dRipl1 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.J Cell Biol 177:659-669.
LINDBERG,A.,M.GAMA-CARVALHO,M.CARMO-FONSECA and J.P.KREIVI,2004 A single RNA recognition motif in splicing factor ASF/SF2 directs it to nuclear sites of adenovirus transcription.J Gen Virol 85:603-608.
LINDBERG,R.A.,A.M.QUINN and T.HUNTER,1992 Dual-specificity protein kinases:Will any hydroxyl do? TIBS 17:114-119.
LONG,J.C.,and J.F.CACERES,2009 The SR protein family of splicing factors:master regulators of gene expression.Biochem J 417:15-27.
LONGLEY,R.L.,JR.,and D.F.READY,1995 Integrins and the development of threedimensional structure in the Drosophila compound eye.Dev Biol 171:415-433.
LONGMAN,D.,I.L.JOHNSTONE and J.F.CACERES,2000 Functional characterization of SR and SR-related genes in Caenorhabditis elegans.EMBO J 19:1625-1637.
LONGMAN,D.,T.MCGARVEY,S.MCCRACKEN,I.L.JOHNSTONE,B.J.BLENCOWE et al.,2001 Multiple interactions between SRm160 and SR family proteins in enhancerdependent splicing and development of C.elegans.Curr Biol 11:1923-1933.
LOPEZ,A.J.,1998 Alternative splicing of pre-mRNA:developmental consequences and mechanisms of regulation.Aunu Rev Genet 32:279-305.
MADHAVAN,M.M.A.S.,H.A.,1977 Histological analysis of the dynamics of growth of imaginal discs and histoblasts nests during the larval development of Drosophila melanogaster.Rouxs Arch Dev Biol 183.
MANIATIS,T.,and B.TASIC,2002 Alternative pre-mRNA splicing and proteome expansion in metazoans.Nature 418:236-243.
MANSILLA,F.,I.FRIIS,M.JADIDI,K.M.NIELSEN,B.F.CLARK et al.,2002 Mapping the human translation elongation factor eLF1H complex using the yeast two-hybrid system.Biochem J 365:669-676.
MAQUAT,L.E.,2004 Nonsense-mediated mRNA decay:splicing,translation and mRNP dynamics.Nat Rev Mol Cell Biol 5:89-99.
MATHUR,S.,K.R.CLEARY,N.INAMDAR,Y.H.KIM,P.STECK et al.,1998 Overexpression of elongation factor-1 gamma protein in colorectal carcinoma.Cancer 82:816- 821.
MATLIN,A.J.,and M.J.MOORE,2007 Spliceosome assembly and composition.Adv Exp Med Biol 623:14-35.
MAYEDA,A.,G.R.SCREATON,S.D.CHANDLER,X.D.Fu and A.R.KRAINER,1999Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements.Mol Cell Biol 19:1853-1863.
MCCRACKEN,S.,M.LAMBERMON and B.J.BLENCOWE,2002 SRm160 splicing coactivator promotes transcript 3'-end cleavage.Mol Cell Biol 22:148-160.
MCCRACKEN,S.,D.LONGMAN,I.L.JOHNSTONE,J.F.CACERES and B.J.BLENCOWE,2003An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.J Biol Chem 278:44153-44160.
MCCRACKEN,S.,D.LONGMAN,E.MARCON,P.MOENS,M.DOWNEY et al.,2005 Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.J Biol Chem 280:42227-42236.
MCCULLOUGH,A.J.,and S.M.BERGET,2000 An intronic splicing enhancer binds U1snRNPs to enhance splicing and select 5' splice sites.Mol Cell Biol 120:9225-9235.
MCGARVEY,T.,E.ROSONINA,S.MCCRACKEN,Q.LI,R.ARNAOUT et al.,2000 The acute myeloid leukemia-associated protein,DEK,forms a splicing-dependent interaction with exon-product complexes.J.Cell Biol.150:309-320.
MEISSNER,M.,S.LOPATO,J.GOTZMANN,G.SAUERMANN and B.A,2003 Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB,SRm160,and SR proteins.Exp Cell Res.283:184-195.
MENEGAY,H.J.,M.P.MYERS,F.M.MOESLEIN and G.E.LANDRETH,2000 Biochemical characterization and localization of the dual specificity kinase CLK1.J.Cell Science 113:3241-3253.
MERMOUD,J.E.,P.T.W.COHEN and A.I.LAMOND,1994 Regulation of mammalian spliceosome assembly by a protein phsophorylation mechanism.EMBO J.13:5679-5688.
MERRICK,W.C.,and J.NYBORG(Editors),2000 The protein synthesis elongation cycle.CSHL Press,Cold Spring Harbor,N.Y.
MIMORI,K.,M.MoP,I,H.INOUE,H.UEO,K.MAFUNE et al.,1996 Elongation factor 1 gamma mRNA expression in oesophageal carcinoma.Gut 38:66-70.
MIMORI,K.,M.MORI,S.TANAKA,T.AKIYOSHI and K.SUGIMACHI,1995a The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.Cancer 75:1446-1449.
MIMORI,K.,M.MORI,S.TANAKA,T.AKIYOSHI and K.SUGIMACHI.1995b The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.Cancer 75:1446-1449.
MINELLA,O.,O.MULNER-LORILLON,V.DE SMEDT,S.HOURDEZ,P.CORMIER et al.,1996Major intracellular localization of elongation factor-1.Cell Mol Biol(Noisy-le-grand)42:805-810.
MINTZ,P.J.,S.O.PATTERSON,A.F.NEUWALD,C.S.SPAHR and D.L.SPECTOR,1999Purification and biochemical characterization of interchromatin granule clusters.EMBO J.18:4308-4320.
MISTELI,T.,1999 RNA splicing:What has phosphorylation got to do with it? Curr.Biol.9:R198-200.
MISTELI,T.,and D.L.SPECTOR,1999 RNA polymerase Ⅱ targets pre-mRNA splicing factors to transcription sites in vivo.Mol Cell 3:697-705.
MITROVICH,Q.M.,and P.ANDERSON,2000 Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C.elegans.Genes Dev 14:2173-2184.
MOESLEIN,F.M.,M.P.MYERS and G.E.LANDRETH,1999 The CLK family kinases CLK1and CLK2 phosphoryate and activate the tyrosine phosphatase PTP-1B.J.Biol.Chem.274:26697-26704.
MOHR,S.E.,S.T.DILLON and R.E.BOSWELL,2001 The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis.Genes Dev 15:2886-2899.
MONNIER,A.,R.BELLE,J.MORALES,P.CORMIER,S.BOULBEN et al.,2001 Evidence for regulation of protein synthesis at the elongation step by CDK1/cyclin B phosphorylation.Nucleic Acids Res 29:1453-1457.
MORALES,J.,P.CORMIER,O.MULNER-LORILLON,R.POULHE and R.BELLE,1992 Molecular cloning of anew guanine nucleotide-exchange protein,EF1 delta.Nucleic Acids Res 20:4091.
MORANTE,J.,C.DESPLAN and A,CELIK,2007 Generating patterned arrays of photoreceptors.Curr Opin Genet Dev 17:314-319.
MORRJS,J.Z.,C.NAVARRO and R.LEHMANN,2003 Identification and analysis of mutations in bob,Doa and eight new genes required for oocyte specification and development in Drosophila melanogaster.Genetics 164:1435-1446.
MORRISON,H.,L.S.SHERMAN,J.LEGG,F.BANINE,C.ISACKE et al.,2001 The NF2 tumor suppressor gene product,merlin,mediates contact inhibition of growth through interactions with CD44.Genes Dev 15:968-980.
MOTOYOSHI,K.,and K.IWASAKI,1977 Resolution of the polypeptide chain elongation factor-1 beta gamma into subunits and some properties of the subunits.J Biochem 82:703-708.
MULNER-LORILLON,O.,P.CORMIER,J.CAVADORE,J.MORALES,R.POULHE et al.,1992a Phosphorylation of Xenopus elongation factor-1γ by cdc2 protein kinase:identification of the phosphorylation site.Exp.Cell Res.202:549-551.
MULNER-LORILLON,O.,P.CORMIER,J.C.CAVADORE,J.MORALES,R.POULHE et al.,1992b Phosphorylation of Xenopus elongation factor-1 gamma by ode2 protein kinase:identification of the phosphorylation site.Exp Cell Res 202:549-551.
MURAKAMI.K.,S.EJIRI and T.KATSUMATA,1978 Elongation factor 1 from the silk gland of silkworm.Effect of EF-1b on EF-1a-and ribosome-dependent GTPase activity.FEBS Lett 92:255-257.
NAGOSHI,R.N.,and B.S.BAKER,1990 Regulation of sex-specific RNA splicing at the Drosophila doublesex gene:cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.Genes Dev.4:89-97.
NAGOSHI,R.N.,M.MCKEOWN,K.C.BURTIS,J.M.BELOTE and B.S.BAKER,1988 The control of alternative splicing at genes regulating sexual differentiation in D.melanogaster.Cell 53:229-236.
NAYLER,O.,F.SCHNORRER,S.STAMM and A.ULLRICH,1998 The cellular localization of the mutine Serine/Arginine-rich protein kinase CLK2 is regulated by Serine 141autophosphorylation.J.Biol.Chem.273:34341-34348.
NAYLER,O.,S.STAMM and A.ULLRICH,1997a Characterization and comparison of four serine- and arginine-rich(SR) protein kinases.Biochem.J.326:693-700.
NAYLER,O.,S.STAMM and A.ULLRICH,1997b Characterization and comparison of four serine- and arginine-rich(SR) protein kinases.Biochem J 326(Pt 3):693-700.
NGO,J.C.,S.CHAKRABARTI,J.H.DING,A.VELAZQUEZ-DONES,B.NOLEN et al.,2005Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.Mol Cell 20:77-89.
NIKOLAKAKI,E.,C.DU,J.LAI,L.CANTLEY,T.GIANNAKOUROS et al.,2002 Phosphorylation by LAMMER protein kinases:determination of a consensus site,identification of in vitro substrates and implications for substrate preferences.Biochemistry 41:2055-2066.
N(O|¨)THIGER,R.,D(U|¨)BENDORFER,A.,EPPER,F.,1977 Gynandromorphs reveal two separate primordia for male and female genitalia.Rouxs Arch.Dev.Biol.181:367-373.
O'CONNELL,P.O.,and M.ROSBASH,1984 Sequence,structure and codon preference of the Drosophila ribosomal protein 49 gene.Nucl.Acid.Res.12:5495-5513.
OHNO,M.,and Y.SHIMURA,1996 A human RNA helicase-like protein,HRH1,facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.Genes Dev 10:997-1007.
OLAREWAJU,O.,P.A.ORTIZ,W.Q.CHOWDHURY,I.CHATTERJEE and T.G.KINZY,2004a The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.RNA Biol 1:89-94.
OLAREWAJU,O.,P.A.ORTZ,W.Q.CHOWDHURY,I.CHATTERJEE and T.G.KINZY,2004b The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.RNA Biology 1:e12-e17.
ORIAN-ROUSSEAU,V.,L.CHEN,J.P.SLEEMAN,P.HERRLICH and H.PONTA,2002 CD44 is required for two consecutive steps in HGF/c-Met signaling.Genes Dev 16:3074-3086.
PADMANABHA,R.,S.GEHRUNG and M.SNYDER,1991 The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family.Mol.Gen.Genet.229:1-9.
PAPAVASSILIOU,A.G.,and D.BOHMANN,1992 Dephosphorylation of phosphoproteins with potato acid phosphatase.Meth.Molec.Cell.Biol.3:149-152.
PARKER,R.,P.G.SILICIANO and C.GUTHRIE,1987 Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.Cell 49:229-239.
PARKHURST,S.M.,and D.ISH-HOROWICZ,1992 Common denominators for sex.Curr Biol 2:629-631.
PEREZ,J.M.,J.KRIEK,J.DIJK,G.W.CANTERS and W.MOLLER,1998 Expression,purification,and spectroscopic studies of the guanine nucleotide exchange domain of human elongation factor,EF-1beta.Protein Expr Purif 13:259-267.
PEREZ,J.M.,G.SIEGAL,J.KRIEK,K.HARD,J.DIJK et al.,1999 The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli.Structure 7:217-226.
PETERS,H.L,Y.W.CHANG and J.A.TRAUGH,1995 Phosphorylation of elongation factor 1(EF-1) by protein kinase C stimulates GDP/GTP-exchange activity.Eur J Biochem 234:550-556.
PINAL,N.,D.C.GOBERDHAN,L.COLLINSON,Y.FUJITA,I.M.COX et al.,2006 Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.Curr Biol 16:140-149.
POMERENING,J.R.,L.VALENTE,T.G.KINZY and T.W.JACOBS,2003 Mutation of a conserved CDK site converts a metazoan Elongation Factor 1Bbeta subunit into a replacement for yeast eEF1Balpha.Mol Genet Genomics 269:776-788.
PONTA,H.,L.SHERMAN and P.A.HERRLICH,2003 CD44:from adhesion molecules to signalling regulators.Nat Rev Mol Cell Biol 4:33-45.
PRASAD,J.,K.COLWILL,T.PAWSON and J.L.MANLEY,1999 The protein kinase Clk/Sty directly modulates SR protein activity:both hyper- and hypophosphorylation inhibit splicing.Mol Cell Biol 19:6991-7000.
PRASAD,J.,and J.L.MANLEY,2003 Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty.Molec.Cell.Biol.23:4139-4149.
RABINOW,L.,and J.A.BIRCHLER,1989 A dosage-sensitive modifier of retrotransposon induced alleles of the Drosophila white locus.EMBO J.8:879-889.
RABINOW,L.,S.L.CHIANG and J.A.BIRCHLER,1993 Mutations at the Darkener of apricot locus modulate transcript levels of copia and copia-induced mutations in Drosophila melanogaster.Genetics 134:1175-1185.
READY,D.F.,T.E.HANSON and S.BENZER,1976 Development of the Drosophila retina,a neurocrystalline lattice.Dev Biol 53:217-240.
REED,R.,1996 Initial splice-site recognition and pairing during pre-mRNA splicing.Curr Opin Genet Dev 6:215-220.
REED,R.,2003 Coupling transcription,splicing and mRNA export.Curr Opin Cell Biol 15:326-331.
RIIS,B.,.S.I.S.RATTAN,B.F.C.CLARK and W.C.MERRICK,1990 Eukaryotic protein elongation factors.Trends Biol.Chem.15:420-424.
ROMEO,Y.,and B.LEMAITRE,2008 Drosophila immunity:methods for monitoring the activity of Toll and Imd signaling pathways.Methods Mol Biol.415:379-394.
ROOKE,J.E.,and T.XU,1998 Positive and negative signals between interacting cells for establishing neural fate.Bioessays 20:209-214.
ROSCIGNO,R.F.,and M.A.GARCIA-BLANCO,1995 SR proteins escort the U4/U6.U5 trisnRNP to the spliceosome.Rna 1:692-706.
ROTH,M.B.,C.MURPHY and J.G.GALL,1990 A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.J Cell Biol 111:2217-2223.
ROTTMAN,F.,A.J.SHATKIN and R.P.PERRY,1974 Sequences containing methylated nucleotides at the 5'termini of messenger RNAs:possible implications for processing.Cell 3:197-199.
RYNER,L.C.,S.F.GOODWIN,D.H.CASTRILLON,A.ANAND,A.VILLELLA et al.,1996Control of male sexual behavior and sexual orientation In Drosophila by the fruitless gene.Cell 87:1079-1089.
SACCO-BUBULYA,P.,and D.L.SPECTOR,2002 Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing.J Cell Biol 156:425-436.
SANCHEZ,L.,CASARES,F.,GORFINKIEL,N.AND GUERRERO,I.,1997 The genital disc of Drosophila melanogaster.Ⅱ.Role of the genes hedgehog,decapentaplegic and wingless.Dev Genes Evol 207:229-241.
SANCHEZ,L.,N.GORFINKIEL and I.GUERRERO,2001 Sex determination genes control the development of the Drosophila genital disc,modulating the response to Hedgehog,Wingless and Decapentaplegic signals.Development 128:1033-1043.
SANCHEZ-HERRERO,E.,I.VERNOS,R.MARCO and G.MORATA,1985 Genetic organization of Drosophila bithorax complex.Nature 313:108-113.
SANDERS,J.,M.BRANDSMA,G.M.JANSSEN,J.DIJK and W.MOLLER,1996Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum.J Cell Sci 109(Pt 5):1113-1117.
SANDERS,J.,R.RAGGIASCHI,J.MORALES and W.MOLLER,1993 The human leucine zippercontaining guanine-nucleotide exchange protein elongation factor-1 delta.Biochim Biophys Acta 1174:87-90.
SANFORD,J.R.,and J.P.BRUZIK,1999 Developmental regulation of SR protein phosphorylation and activity.Genes Dev 13:1513-1518.
SANFORD,J.R.,and J.P.BRUZIK,2001a Regulation of SR protein localization during development.Proc Natl Acad Sci U S A 98:10184-10189.
SANFORD,J.R.,and J.P.BRUZIK,2001b Regulation of SR protein localization during development.Proc Natl Acad Sci U S A 98:10184-10189.
SANFORD,J.R.,D.LONGMAN and J.F.CACERES,2003 Multiple roles of the SR protein family in splicing regulation.Prog Mol Subcell Biol 31:33-58.
SATOH,A.K.,J.E.O'TOUSA,K.OZAKI and D.F.READY,2005 Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors.Development 132:1487-1497.
SAVALDI-GOLDSTEIN,S.,G.SESSA and R.FLUHR,2000 The ethylene-inducible PK12 kinase mediates the phosphorylation of SR splicing factors.Plant Journ.21:91-96.
SCHAAL,T.D.,and T.MANIATIS,1999 Selection and characterization of pre-mRNA splicing enhancers:identification of novel SR protein-specific enhancer sequences.Mol Cell Biol 19:1705-1719.
SCHULTZ,J.,T.JONES,P.BORK,D.SHEER,S.BLENCKE et al.,2001 Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35[correction of 4q35].Genomics 71:368-370.
SCH(U|¨)PBACH,T.,WIESCHAUS,E.,N(O|¨)THIGER,R.,1978 The embryonic organization of the genital disc studied in genetic mosaics of Drosophila melangaster.Rouxs Arch.Dev.Biol.185:249-270.
SCHUTT,C.,and R.NOTHIGER,2000 Structure,function and evolution of sex-determining systems in Dipteran insects.Development 127:667-677.
SCHWEITZER,R.,R.HOWES,R.SMITH,B.Z.SHILO and M.FREEMAN,1995 Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.Nature 376:699-702.
SCIABICA,K.S.,Q.J.DAI and R.M.SANDRI-GOLDIN,2003 ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation.Embo J 22:1608-1619.
SEFTON,L.,J.R.TIMMER,Y.ZHANG,F.BERANGER and T.W.CLINE,2000 An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element.Nature 405:970-973.
SEIF,I.,G.KHOURY and R.DHAR,1979 BKV splice sequences based on analysis of preferred donor and acceptor sites.Nucleic Acids Res 6:3387-3398.
SERRANO,N.,and P.H.O'FARRELL,1997 Limb morphogenesis:connections between patterning and growth.Curr Biol 7:R186-195.
SESSA,G.,V.RAZ,S.SAVALDI and R.FLUHR,1996 PK12,a plant dual-specificity protein kinase of the LAMMER family,is regulated by the hormone ethylene.Plant Cell 8:2223-2234.
SHARP,P.A.,1994 Split genes and RNA splicing.Cell 77:805-815.
SHEAR.N,A.,and A.GAREN,1974 Genetic control of imaginal disc development in Drosophila.Proc Natl Acad Sci U S A 71:1393-1397.
SHEN,H.,and M.R.GREEN,2004 A pathway of sequential arginine-serine-rich domainsplicing signal interactions during mammalian spliceosome assembly.Mol Cell 16:363-373.
SHEN,H.,and M.R.GREEN,2006 RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans.Genes Dev 20:1755-1765.
SHEN,H.,J.L.KAN and M.R.GREEN,2004 Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly.Mol Cell 13:367-376.
SHEU,G.T.,and J.A.TRAUGH,1997 Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli.Subunit interactions,elongation activity,and phosphorylation by protein kinase CKII.J Biol Chem 272:33290-33297.
SHI,Y.,D.C.DI GIAMMARTINO,D.TAYLOR,A.SARKESHIK,W.J.RICE et al.,2009Molecular architecture of the human pre-mRNA 3' processing complex.Mol Cell 33:365-376.
SHIN,C.,Y.FENG and J.L.MANLEY,2004 Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.Nature 427:553-558.
SHIN,C.,and J.L.MANLEY,2002 The SR protein SRp38 represses splicing in M phase cells.Cell 111:407-417.
SLOBIN,L.I.,and W.MOLLER,1978 Purification and properties of an elongation factor functionally analogous to bacterial elongation factor Ts from embryos of Artemia salina.Eur.J.Biochem.84:69-77.
SOSNOWSKI,B.A.,J.M.BELOTE and M.MCKEOWN,1989 Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage.Cell 58:449-459.
STAFFA,A.,and A.COCHRANE,1995 Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1.Mol Cell Biol 15:4597-4605.
STANYON,C.A.,G.LIU,B.A.MANGIOLA,N.PATEL,L.GIOT et al.,2004 A Drosophila protein-interaction map centered on cell-cycle regulators.Genome Biol 5:R96.
STAUDINGER,J.,M.PERRY,S.J.ELLEDGE and O.E.N.,1993 Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system.J.Biol.Chem.268:4608-4611.
STEINMANN-ZWICKY,M.,H.AMREIN and R.NOTHIGER,1990 Genetic control of sex determination in Drosophila.Adv Genet 27:189-237.
STEVENS,S.W.,D.E.RYAN,H.Y.GE,R.E.MOORE,M.K.YOUNG et al.,2002Composition and functional characterization of the yeast spliceosomal penta-snRNP.Mol Cell 9:31-44.
STOKS,M.P.,J.RUSH,J.MACNEILL,J.M.REN,K.SPROTT et al.,2007 Profiling of UV-induced ATM/ATR signaling pathways.Proc Natl Aead Sci U S A 104:19855-19860.
STRUTT,D.I.,V.WIERSDORFF and M.MLODZIK,1995 Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A.Nature 373:705-709.
STRUTT,H.,and D.STRUTT,2003 EGF signaling and ommatidial rotation in the Drosophila eye.Curr Biol 13:1451-1457.
STUART,L.M.,J.BOULAIS,G.M.CHARRIERE,E.J.HENNESSY,S.BRUNET et al.,2007a A systems biology analysis of the Drosophila phagosome.Nature 445:95-101.
STUART,L.M.,J.BOULAIS,G.M.CHARRIERE,E.J.HENNESSY,S.BRUNET et al.,2007b A systems biology analysis of the Drosophila phagosome.Nature 445:95-101.
SUREAU,A.,R.GATTONI,Y.DOOGHE,J.STEVENIN and J.SORET,2001 SC35 autoregnlates its expression by promoting splicing events that destabilize its mRNAs.Embo J 20:1785-1796.
SZYMCZYNA,B.R.,J.BOWMAN,S.MCCRACKEN,A.PINEDA-LUCENA,Y.Lu et al.,2003Structure and function of the PWI motif:a novel nucleic acid-binding domain that facilitates pre-mRNA processing.Genes Dev 17:461-475.
T. WOLFF, D. F. R., 1993 The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, N. Y.
Tacke, R., and J. L. Manley, 1999 Determinants of SR protein specificity. Curr Opin Cell Biol 11: 358-362.
Talmadge, K., S. Finkernagel, L. Sciorra, J. Sumegi and L. Rabinow, 1998 Chromosomal mapping of three human LAMMER protein kinase-encoding genes. Human Genetics 103: 523-524.
Tang, Z., T. Kuo, J. Shen and R. J. Lin, 2000 Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol Cell Biol 20: 816- 824.
Tang, Z., A. Tsurumi, S. Alaei, C. Wilson, C. Chiu et al, 2007 Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast. Biochem J 405: 21-30.
Tange, T. O., A. Nott and M. J. Moore, 2004 The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol 16: 279-284.
TAUTZ, D., and C. Pfeifle, 1989 A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81-85.
Taylor, B. J., A. Villella, L. C. Ryner, B. S. Baker and J. C. Hall, 1994 Behavioral and neurobiological implications of sex-determining factors in Drosophila. Dev Genet 15: 275-296.
Tepass, U., and K. P. Harris, 2007 Adherens junctions in Drosophila retinal morphogenesis. Trends Cell Biol 17: 26-35.
Tian, M., and T. Maniatis, 1993 A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74: 105-114.
Tintaru, A. M., G. M. Hautbergue, A. M. Hounslow, M. L. Hung, L. Y. Lian et al, 2007 Structural and functional analysis of RNA and TAP binding to SF2/ASF. EMBO Rep 8: 756-762.
Tio, M., and K. Moses, 1997 The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 124: 343-351.
Tokumoto, T., A. Kondo, J. Miwa, R. Horiguchi, M. Tokumoto et al, 2003 Regulated interaction between polypeptide chain elongation factor-1 complex with the 26S proteasome during Xenopus oocyte maturation. BMC Biochem 4: 6.
Tomlinson, A., and D. F. Ready, 1987 Cell fate in the Drosophila ommatidium. Dev. Biol. 123: 264- 275.
Tomlinson, A., and G. Struhl, 2001 Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor. Mol Cell 7: 487-495.
Tomlinson, G. C. a. A., 1995 Initiation of the proximodistal axis in insect legs. Development 121: 619-628.
Treisman, J. E., and G. M. Rubin, 1995 wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121: 3519-3527.
van Buskirk, C., and T. Schupbach, 1999 Versatility in signalling: multiple responses to EGF receptor activation during Drosophila oogenesis. Trends Cell Biol. 9: 1-4.
van Damme, H., R. Amons, G. Janssen and W. Moller, 1991 Mapping the functional domains of the eukaryotic elongation factor 1 beta gamma. Eur J Biochem 197: 505- 511.
van Damme, H. T., R. Amons, R. Karssies, C. J. Timmers, G. M. Janssen et al, 1990 Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta. Biochim Biophys Acta 1050: 241-247.
VANWETSWrNKEL,S.,J.KRIEK,G.R.ANDERSEN,P.GUNTERT,J.DIJK et al.,2003 Solution structure of the 162 residue C-terminal domain of human elongation factor 1Bgamma.J Biol Chem 278:43443-43451.
VENEMA,,R.C.,H.I.PETERS and J.A.TRAUGH,1991 a Phosphorylation of elongation factor 1(EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1activity.J Biol Chem 266:12574-12580.
VENEMA,R.C.,H.I.PETERS and J.A.TRAUGH,1991b Phosphorylation of valyl-tRNA synthetase and elongation factor 1 in response to phorbol esters is associated with stimulation of both activities.J Biol Chem 266:11993-11998.
VOAS,M.G.,and I.REBAY,2004 Signal integration during development:insights from the Drosophila eye.Dev Dyn 229:162-175.
YON STEIN,W.,A.RAMRATH,A.GRIMM,M.MULLER-BORG and A.WODARZ,2005 Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling.Development 132:1675-1686.
W.C.MERRICK,J.N.,2000 The protein synthesis elongation cycle,pp.89-125 in Translational Control of Gene Expression,edited by J.H.N.SONENBERG,M.MATHEWS.CSHL Press,New York.
WAGNER,S.,S.CHIOSEA,M.IVSHINA and J.A.NICKERSON,2004 In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.J Cell Biol 164:843-850.
WAGNER,S.,S.CHIOSEA and J.A.NICKERSON,2003 The spatial targeting and nuclear matrix binding domains of SRm160.Proc.Natl.Acad.Sci.100:3269-3274.
WAN,K.M.,J.A.NICKERSON,G.KROCKMALNIC and S.PENMAN,1994 The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis.Proc.Natl.Acad.Sci.USA 91:594-598.
WANG,H.Y.,W.LIN,J.A.DYCK,J.M.YEAKLEY,Z.SONGYANG et al.,1998 SRPK2:a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.J.Cell Biol.140:737-750.
WANG,J.,P.J.SMITH,A.R.KRAINER and M.Q.ZHANG,2005 Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes.Nucleic Acids Res 33:5053-5062.
WANG,Z.,and C.B.BURGE,2008 Splicing regulation:from a parts list of regulatory elements to an integrated splicing code.Rna 14:802-813.
WASSARMAN,D.A.,M.THERRIEN and G.M.RUBIN,1995 The Ras signaling pathway in Drosophila.Curr Opin Genet Dev 5:44-50.
WATKINS-CHOW,D.E.,K.R.DOUGLAS,M.S.BUCKWALTER,F.J.PROBST and S.A.CAMPER,1997 Construction of a 3-Mb contig and partial transcript map of the central region of mouse chromosome 11.Genomics 45:147-157.
WEAVER,T.A.,and R.A.WHITE,1995 headcase,an imaginal specific gene required for adult morphogenesis in Drosophila melanogaster.Development 121:4149-4160.
WIERSDORFF,V.,T.LECUIT,S.M.COHEN and M.MLODZIK,1996 Mad acts downstream of Dpp receptors,revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye.Development 122:2153-2162.
WIESCHAUS,E.,and R.NOTHIGER,1982 The role of the transformer genes in the development of genitalia and analia of Drosophila melanogaster.Dev Biol 90:320-334.
WOLFF,T.,2003 EGF receptor signaling:putting a new spin on eye development.Curr Biol 13:R813-814.
Wolff, T., and D. F. Ready, 1993 The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, N. Y.
Wu, J. Y., and T. Maniatis, 1993 Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75:1061-1070.
Xiao, S. H., and J. L. Manley, 1997 Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev 11: 334-344.
Xiao, S. H., and J. L. Manley, 1998 Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. Embo J 17: 6359-6367.
Xu, T., and G. M. Rubin, 1993 Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
Yaffe, M. B., G. G. Leparc, J. Lai, T. Obata, S. Volinia et al, 2001 A motif-based scanning approach for genome-wide prediction of signaling pathways. Nature Biotech. 19: 348-353.
Yang, L., and N. E. Baker, 2003 Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev Cell 4: 359-369.
Yang, L., and N. E. Baker, 2006 Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye. BMC Dev Biol 6: 8.
Yang, Y., W. Zhang, J. R. Bayrer and M. A. Weiss, 2008 Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: structure, function, and mutagenesis of a female-specific domain. J Biol Chem 283: 7280-7292.
Yeo, G., S. Hoon, B. Venkatesh and C. B. Burge, 2004 Variation in sequence and organization of splicing regulatory elements in vertebrate genes. Proc Natl Acad Sci U S A 101:15700-15705.
Yun, B., R. Farkas, K. Lee and L. Rabinow, 1994 The Doa locus encodes a member of a new protein kinase family, and is essential for eye and embryonic development in Drosophila melanogaster. Genes Dev. 8: 1160-1173.
Yun, B., K. Lee, R. Farkas, C. Hitte and L. Rabinow, 2000a The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells, and is expressed as both nuclear and cytoplasmic isoforms throughout development. Genetics 156: 749-761.
Yun, B., K. Lee, R. Farkas, C. Hitte and L. Rabinow, 2000b The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells and is expressed as both nuclear and cytoplasmic isoforms throughout development. Genetics 156: 749-761.
Yun, C. Y., and X. D. Fu, 2000 Conserved SR Protein Kinase Functions in Nuclear Import and Its Action Is Counteracted by Arginine Methylation in Saccharomyces cerevisiae. J. Cell Biology 150:707-718.
Yun, C. Y., A. L. Velazquez-Dones, S. K. Lyman and X. D. Fu, 2003 Phosphorylation- dependent and -independent nuclear import of RS domain-containing splicing factors and regulators. J Biol Chem 278:18050-18055.
Zahler, A. M., W. S. Lane, J. A. Stolk and M. B. Roth, 1992 SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev 6: 837-847.
Zavortink, M., and S. Sakonju, 1989 The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters. Genes Dev 3: 1969-1981.
Zhai, B., J. Villen, S. A. Beausoleil, J. Mintseris and S. P. Gygi, 2008 Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res 7: 1675-1682.
ZHENG,Z.M.,2004 Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression.J Biomed Sci 11:278-294.
ZHOU,Z.,L.J.LICKLIDER,S.P.GYGI and R.REED,2002 Comprehensive proteomic analysis of the human spliceosome.Nature 419:182-185.
ZHOU,Z.,and R.REED,1998 Human homologs.of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step Ⅱ of pre-mRNA splicing.Embo J 17:2095-2106.
ZHU,L.,J.WILKEN,N.B.PHILLIPS,U.NARENDRA,G.CHAN et al.2000 Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.Genes Dev 14:1750-1764.
Alber, T., 1992 Structure of the leucine zipper. Curr Opin Genet Dev 2: 205-210.
Amons, R., M. A. Guerrucci, R. H. Karssies, J. Morales, P. Cormier et al, 1994 The leucine-zipper in elongation factor EF-1 delta, a guanine-nucleotide exchange protein, is conserved in Artemia and Xenopus. Biochim Biophys Acta 1218: 346-350.
Amrein, H., M. Gorman and R. Nothiger, 1988 The sex-determining gene tra2 of Drosophila encodes a putative RNA binding protein. Cell 55: 1025-1035.
An, W., S. Cho, H. Ishii and P. C. Wensink, 1996 Sex-specific and non-sex-specific oligomerization domains in both of the doublesex transcription factors from Drosophila melanogaster. Mol Cell Biol 16: 3106-3 111.
Andersen, G. R., P. Nissen and J. Nyborg, 2003 Elongation factors in protein biosynthesis. Trends Biochem Sci 28: 434-441.
Arbeitman, M. N., E. E. M. Furlong, F. Imam, E. Johnson, B. H. Null et al, 2002 Gene expression during the life cycle of Drosophila melanogaster. Science 297: 2270-2275.
Arikawa, K., J. L. Hicks and D. S. Williams, 1990 Identification of actin filaments in the rhabdomeral microvilli of Drosophila photoreceptors. J Cell Biol 110: 1993-1998.
Ashburner, M., 1989 Drosophila- a laboratory handbook. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman et al. (Editors), 1989 Curr. Prot. Molec. Biol Greene/Wiley Publishing, N.Y.
Avila, F. W., and J. W. Erickson, 2007 Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Curr Biol 17: 643-648.
Baker, B. S., 1989 Sex in flies: the splice of life. Nature 340: 521-524.
Baker, N. E., S. Yu and D. Han, 1996 Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol 6: 1290-1301.
Baker, N. E., and S. Y. Yu, 1998 The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose. Mech Dev 74: 3-14.
Baker, N. E., and S. Y. Yu, 2001 The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 104: 699-708.
Baker, N. E., and A. E. Zitron, 1995 Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous. Mech Dev 49: 173-189.
Barbash, D. A., and T. W. Cline, 1995 Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster. Genetics 141: 1451-1471.
Basler, K., and E. Hafen, 1989 Dynamics of Drosophila eye development and temporal requirements of sevenless expression. Development 107: 723-731.
Beausoleil, S. A., M. Jedrychowski, D. Schwartz, J. E. Elias, J. Villen et al, 2004 Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101:12130-12135.
Bec, G., P. Kerjan and J. P. Waller, 1994 Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation.J Biol Chem 269:2086-2092.
BECKER,W.,H.KENTRUP,J.HEUKELBACH and H.G.JOOST,1996 cDNA cloning and characterization of rat Clk3,a LAMMER kinase predominantly expressed in testis.Biochem.Biophys.Acta 1312:63-67.
BELL,L.R.,J.I.HORABIN,P.SCHEDL and T.W.CLINE,1991 Positive autoregulation of sexlethal by alternative splicing maintains the female determined state in Drosophila.Cell 65:229-239.
BELL,L.R.,E.M.MAINE,P.SCHEDL and T.W.CLNE,1988 Sex-lethal,a Drosophila sexdetermination switch gene,exhibits sex-specific RNA splicing and sequence similarity to RNA-binding proteins.Cell 55:1037-1046.
BELLE,R.,J.DERANCOURT,R.POULHE,J.-P.CAPONY,R.OZON et al.,1989 A purified complex from Xenopus oocytes contains a P-47 protein,an in vivo substrate of MPF,and a p30 protein respectively homologous to elongation factors EF1γ and EF1B.FEBS 255:101-104.
BELOTE,J.M.,M.MCKEOWN,R.T.BOGGS,R.OHKAWA and B.A.SOSNOWSKI,1989Molecular genetics of transformer,a genetic switch controlling sexual differentiation in Drosophila.Dev Genet 10:143-154.
BEN-DAVID,Y.,K.LETWIN,L.TANNOCK,A.BERNSTEIN and T.PAWSON,1991 A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.EMBO J.10:317-325.
BENDER,J.,and G.R.FINK,1994 AFC1,a LAMMER kinase from Arabidopsis thaliana,activates STE12-dependent processes in yeast.Proc.Natl.Acad.Sci.USA 91:12105-12109.
BERGET,S.M.,and P.A.SHARP,,1977 A spliced sequence at the 5'-terminus of adenovirus late mRNA.Brookhaven Symp Biol:332-344.
BINGHAM,P.M.,and B.H.JUDD,1981 A copy of the copia transposable element is very tightly linked to the w~a allele at the white locus of D.melanogaster.Cell 25:705-711.
BIRNEY,E.,S.KUMAR and A.R.KRAINER,1993 Analysis of the RNA-recognition motif and RS and RGG domains:conservation in metazoan pre-mRNA splicing factors.Nucleic Acids Res 21:5803-5816.
BLACK,D.L.,2003 Mechanisms of alternative pre-messenger RNA splicing.Annu Rev Biochem 72:291-336.
BLACKMAN,R.K.,M.SANICOLA,L.A.RAFTERY,T.GILLEVET and W.M.GELBART,1991An extensive 3' cis-regulatory region directs the imaginal disk expression of decapentaplegic,a member of the TGF-beta family in Drosophila.Development 111:657-666.
BLANCHARD,J.M.,J.WEBER,W.JELINEK and J.E.DARNELL,1978 In vitro RNA-RNA splicing in adenovirus 2 mRNA formation.Proc Natl Acad Sci U S A 75:5344-5348.
BLENCOWE,B.J.,2000 Exonic splicing enhancers:mechanism of action,diversity and role in human genetic diseases.Trends Biochem Sci 25:106-110.
BLENCOWE,B.J.,G.BAUREN,A.G.ELDRIDGE,R.ISSNER,J.A.NICKERSON et al.,2000 The SRm160/300 splicing coactivator subunits.RNA 6:111-120.
BLENCOWE,B.J.,J.A.BOWMAN,S.MCCRACKEN and E.ROSONINA,1999 SR-related proteins and the processing of messenger RNA precursors.Biochem Cell Biol.77:277-291.
BLENCOWE,B.J.,R.ISSNER,J.A.NICKERSON and P.A.SHARP,1998 A coactivator of pre-mRNA splicing.Genes Dev.12:996-1009.
BLENCOWE,B.J.,and C.A.OUZOUNIS,1999 The PWI motif:a new protein domain in splicing factors.Trends Biochem Sci 24:179-180.175_00001387.
Bodenmiller, B., D. Campbell, B. Gerrits, H. Lam, M. Jovanovic et al, 2008 PhosphoPep--a database of protein phosphorylation sites in model organisms. Nat Biotechnol 26: 1339-1340.
Booggs, R. T., P. Gregor, S. Idriss, J. M. Belote and M. McKeown, 1987 Regulation of sexual differentiation via alternative processing of RNA from the transformer gene. Cell 50: 739-747.
Boucher, L., C. A. Ouzounis, A. J. Enright and B. J. Blencowe, 2001 A genome-wide survey of RS domain proteins. Rna 7: 1693-1701.
Brand, A., and N. Perrimon, 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
Breathnach, R., C. Benoist, K. O'Hare, F. Gannon and P. Chambon, 1978 Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A 75: 4853-4857.
Brennan, C. A., and K. Moses, 2000 Determination of Drosophila photoreceptors: timing is everything. Cell Mol Life Sci 57: 195-214.
Bridges, C. B., 1921 Triploid Intersexes in Drosophila Melanogaster. Science 54: 252-254.
Brody, T. B., 1995 The Interactive Fly pp. in Genes involved in tissue and organ development.
Brook, W. J., F. J. Diaz-Benjumea and S. M. Cohen, 1996 Organizing spatial pattern in limb development. Annu Rev Cell Dev Biol 12:161-180.
Brown, K. E., and M. Freeman, 2003 Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye. Development 130: 5401-5412.
Brown, N. L., C. A. Sattler, S. W. Paddock and S. B. Carroll, 1995 Hairy and emc negatively regulate morphogenetic furrow progression in the Drosophila eye. Cell 80: 879-887.
Burtis, K. C., and B. S. Baker, 1989 Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex- specific polypeptides. Cell 56: 997-1010.
Caceres, J. F., G. R. Screaton and A. R. Krainer, 1998 A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev. 12: 55-66.
Cagan, R. L., and D. F. Ready, 1989 The emergence of order in the Drosophila pupal retina. Develop. Biol. 136: 346-362.
Campos-Ortega, J. A., and V. Hartenstein, 1997 The embryonic development of Drosophila melanogaster. Springer, Berlin.
Cao, W., S. F. Jamison and M. A. Garcia-Blanco, 1997 Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro. Rna 3: 1456-1467.
Caputi, M., G. Casari, S. Guenzi, R. Tagliabue, A. Sidoli et al, 1994 A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon. Nucleic Acids Res 22: 1018-1022.
Carr-Schmid, A., L. Valente, V. I. Loik, T. Williams, L. M. Starita et al, 1999 Mutations in elongation factor 1beta, a guanine nucleotide exchange factor, enhance translational fidelity. Mol Cell Biol 19: 5257-5266.
Carvalho, M. D., J. F. Carvalho and W. C. Merrick, 1984a Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes. Arch Biochem Biophys 234: 603-611.
Carvalho, M. G., J. F. Carvalho and W. C. Merrick, 1984b Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes. Arch. Biochem. Biophys. 234:603-611.
Casanova, J., E. Sanchez-Herrero and G. Morata, 1986 Identification and characterization of a parasegment specific regulatory element of the abdominal-B gene of Drosophila. Cell 47: 627-636.
Casares, F., SAnchez, L., Guerrero, I. and Sanchez-Herrero, E., 1997 The genital disc of Drosophila melanogaster. I. Segmental and compartmental organization. Dev Genes Evol 207:216-228.
Celniker, S. E., D. J. Keelan and E. B. Lewis, 1989 The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain.. Genes Dev 3: 1424-1436.
Chang, H. Y., and D. F. Ready, 2000 Rescue of photoreceptor degeneration in rhodopsin- null Drosophila mutants by activated Racl. Science 290: 1978-1980.
Chang, Y. F., J. S. Imam and M. F. Wilkinson, 2007 The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76: 51-74.
Chang, Y. W., and J. A. Traugh, 1997 Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation. J Biol Chem 272: 28252-28257.
Chang, Y. W., and J. A. Traugh, 1998 Insulin stimulation of phosphorylation of elongation factor 1 (eEF-1) enhances elongation activity. Eur J Biochem 251: 201-207.
Chen, C. J., and J. A. Traugh, 1995 Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II. Biochim Biophys Acta 1264:303-311.
Chen, E. H., and B. S. Baker, 1997 Compartmental organization of the Drosophila genital imaginal discs. Development 124: 205-218.
Cheng, C., and P. A. Sharp, 2006 Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol 26: 362-370.
Chew, S. L., H. X. Liu, A. Mayeda and A. R. Krainer, 1999 Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A 96: 10655-10660.
Choi, K. W., and S. Benzer, 1994 Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene. Cell 78:125-136.
Chou, T. B., Z. Zachar and P. M. Bingham, 1987 Developmental expression of a regulatory gene is programmed at the level of splicing. Embo J 6: 4095-4104.
Chou, Y. H., and C. T. Chien, 2002 Scabrous controls ommatidial rotation in the Drosophila compound eye. Dev Cell 3: 839-850.
Chow, L. T., R. E. Gelinas, T. R. Broker and R. J. Roberts, 1977 An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell 12:1-8.
Cline, T. W., 1988 Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states. Genetics 119: 829-862.
Colwill, K., L. L. Feng, J. M. Yeakley, G. D. Gish, J. F. Caceres et al, 1996a SRPK1 and Clk/STY protein kinases show distinct substrate specificities for Serine/Arginine- rich splicing factors. J. Biol.Chem. 271: 24569-24575.
Colwill, K., T. Pawson, B. Andrews, J. Prasad, J. L. Manley et al, 1996b The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. Embo J 15: 265-275.
Colwill, K., T. Pawson, B. Andrews, J. Prasad, J. L. Manley et al, 1996c The Clk/STY protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 15:265-275.
Cooper, M. T., and S. J. Bray, 2000 R7 photoreceptor specification requires Notch activity. Curr Biol 10: 1507-1510.
Cormier, P., H. B. Osborne, J. Morales, T. Bassez, R. Poule et al, 1991 Molecular cloning of
Xenopus elongation factor 1γ, major M-phase promoting factor substrate. Nuc. Acids Res. 19: 6644.
Cox, R. A., 1968 The use of guanidium chloride in the isolation of nucleic acids. Meth. Enz. 12: 120-129.
Cuccurese, M., G. Russo, A. Russo and C. Pietropaolo, 2005 Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression. Nucleic Acids Res 33: 5965-5977.
Curtiss, J., and M. Mlodzik, 2000 Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development 127: 1325-1336.
Custodio, N., C. Carvalho, I. Condado, M. Antoniou, B. J. Blencowe et al, 2004 In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei. Rna 10: 622-633.
Das, P., L. L. Maduzia, H. Wang, A. L. Finelli, S. H. Cho et al, 1998 The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125: 1519-1528.
Dasmahapatra, B., L. Skogerson and K. Chakraburtty, 1981 Protein synthesis in yeast II. Purification and properties of elongation factor 1 from Saccharomyces cerevisiae. J. Biol. Chem. 256: 10005-10011.
Dauksaite, V., and G. Akusjarvi, 2004 The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection. Biochem J 381: 343-350.
Dauwalder, B., S. Tsujimoto, J. Moss and W. Mattox, 2002 The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. Genes Dev 16: 2879-2892.
Del Gatto, F., and R. Breathnach, 1995 Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol 15: 4825-4834.
Dokucu, M. E., S. L. Zipursky and R. L. Cagan, 1996 Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina. Development 122:4139-4147.
Dominguez, M., 1999 Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development. Development 126: 2345-2353.
Dominguez, M., and J. F. de Celis, 1998 A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 396: 276-278.
Dominguez, M., and E. Hafen, 1997 Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye. Genes Dev 11: 3254-3264.
Dominguez, M., J. D. Wasserman and M. Freeman, 1998 Multiple functions of the EGF receptor in Drosophila eye development. Curr Biol 8: 1039-1048.
Dorsett, D., 1990 Potentiation of a polyadenylation site by a downstream protein-DNA interaction. Proc. Natl. Acad. Sci. USA 87:4373-4377.
Du, C., M. E. McGuffin, B. Dauwalder, L. Rabinow and W. Mattox, 1998 Protein phosphorylation plays an essential role in the regulation of alternative splicing and sex determination in Drosophila. Molecular Cell 2: 741-750.
Duffy, J. B., and J. P. Gergen, 1991 The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex- determining gene Sex-lethal. Genes Dev 5: 2176-2187.
DUNCAN,P.I.,D.F.STOJDL,R.M.MARIUS and J.C.BELL,1997 In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.Mol.Cell.Biol.17:5996-6001.
DUNCAN,P.I.,D.F.STOJDL,R.M.MAGUS,K.H.SCHEIT and J.C.BELL,1998 The Clk2and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.Exp.Cell Res.241:300-308.
DURFEE,T.,K.BECHERER,P.L.CHEN,S.H.YEH,Y.YANG et al.,1993 The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.Genes Develop.7:555-569.
EDMONDS,M.,M.H.VAUGHAN,JR.and H:NAKAZATO,1971 Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells:possible evidence for a precursor relationship.Proc Natl Acad Sci U S A 68:1336-1340.
EJIRI,S.,2002 Moonlighting functions of polypeptide elongation factor 1:from actin bundling to zinc finger protein R1-associated nuclear localization.Biosci Biotechnol Biochem 66:1-21.
EJIRI,S.,N.EBATA,R.KAWAMURA and T.KATSUMATA,1983 Occurrence of four subunits in high molecular weight forms of polypeptide chain elongation factor 1 from wheat embryo.J Biochem 94:319-322.
ELDRIDGE,A.G.,Y.LI,P.A.SHARP and B.J.BLENCOWE,1999 The SRm160/300 splicing coactivator is required for exon-enhancer function.Proc Natl Acad Sci 96:6125-6130.
EPPER,F.,and R.NOTHIGER,1982 Genetic and developmental evidence for a repressed genital primordium in Drosophila melanogaster.Dev Biol 94:163-175.
ESTES,P.A.,L.N.KEYES and P.SCHEDL,1995 Multiple response elements in the Sex-lethal early promoter ensure its female-specific expression pattern.Mol Cell Biol 15:904-917.
ESTRADA,B.,F.CASARES and E.SANCHEZ-HERRERO,2003 Development of the genitalia in Drosophila melanogaster.Differentiation 71:299-310.
ESTRADA,B.,and E.SANCHEZ-HERRERO,2001 The Hox gene Abdominal-B antagonizes appendage development in the genital disc of Drosophila.Development 128:331-339.
FEHON,R.G.,K.JOHANSEN,I.REBAY and S.ARTAVANIS-TSAKONAS,1991 Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila:implications for notch function.J Cell Biol 113:657-669.
FISCHER-VIZE,J.A.,G.M.RUBIN and R.LEHMANN,1992 The fat facets gene is required for Drosophila eye and embryo development.Development 116:985-1000.
FLAHERTY,S.M.,P.FORTES,E.IZAURRALDE,I.W.MATTAJ and G.M.GrLMARTIN,1997Participation of the nuclear cap binding complex in pre-mRNA 3' processing.Proc Natl Acad Sci U S A94:11893-11898.
FOLEY,E.,and P.H.O'FARRELL,2004a Functional dissection of an innate immune response by a genome-wide RNAi screen.PLos Biology 2:1091-1106.
FOLEY,E.,and P.H.O'FARRELL,2004b Functional dissection of an innate immune response by a genome-wide RNAi screen.PLoS Biol 2:E203.
FORCH,P.,and J.VALCARCEL,2003 Splicing regulation in Drosophila sex determination.Prog Mol Subcell Biol 31:127-151.
FORTINI,M.E.,I.REBAY,L.A.CARON and S.ARTAVANIS-TSAKONAS,1993 An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye.Nature 365:555-557.
FRANKFORT,B.J.,and G.MARDON,2002 R8 development in the Drosophila eye:a paradigm for neural selection and differentiation.Development 129:1295-1306.
FREELAND,D.E.,and D.T.KUHN,1996 Expression patterns of developmental genes reveal segment and parasegment organization ofD.melanogaster genital discs.Mech Dev 56:61-72.
FREEMAN,M.,1996 Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.Cell 87:651-660.
FREEMAN,M.,1997 Cell determination strategies in the Drosophila eye.Development 124:261-270.
FREEMAN,M.,C.KLAMBT,C.S.GOODMAN and G.M.RUBIN,1992 The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.Cell 69:963-975.
FRENDEWEY,D.,and W.KELLER,1985 Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences.Cell 42:355-367.
Fu,X.D.,1995 The superfamily of arginine/serine-rich splicing factors.Rna 1:663-680.
FU,X.D.,and T.MANIATIS,1992 The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3'splice site.Proc Natl Acad Sci U S A 89:1725-1729.
GAENGEL,K.,and M.MLODZIK,2003 Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.Development 130:5413-5423.
GATFIELD,D.,and E.IZAURRALDE,2002 REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export.J.Cell Biol.159:579-588.
GE,H.,and J.L.MANLEY,1990 A protein factor,ASF,controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro.Cell 62:25-34.
GELLON,G.,and W.MCGINNIS,1998 Shaping animal body plans in development and evolution by modulation of Hox expression patterns.Bioessays 20:116-125.
GILBERT,W.,and C.GUTHRIE,2004 The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA.Mol Cell 13:201-212.
GILLEN,C.M.,Y.GAO,M.M.NIEHAUS-SAUTER,M.R.WYLDE and M.G.WHEATLY,2008Elongation factor 1Bgamma(eEF1Bgamma) expression during the molting cycle and cold acclimation in the crayfish Procambarus clarkii.Comp Biochem Physiol B Biochem Mol Biol.150:170-176.
GIOT,L.,J.S.BADER,C.BROUWER,A.CHAUDHURI,B.KUANG et al.,2003 A protein interaction map of Drosophila melanogaster.Science 302:1727-1736.
GOLEMBO,M.,R.SCHWEITZER,M.FREEMAN and B.Z.SHILO,1996 Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop.Development 122:223-230.
GORSKI,S.M.,S.CHITTARANJAN,E.D.PLEASANCE,J.D.FREEMAN,C.L.ANDERSON et al.,2003a A SAGE approach to discovery of genes involved in autophagic cell death.Curr Biol 13:358-363.
GORSKI,S.M.,S.CHITTARANJAN,E.D.PLEASANCE,J.D.FREEMAN,C.L.ANDERSON et al.,2003b A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death.Curr Biol 13:358-363.
GRABOWSKI,P.J.,1998 Splicing regulation in neurons:Tinkering with cell-specific control.Cell 92:709-712.
GRABOWSKI,P.J.,and D.L.BLACK,2001 Alternative RNA splicing in the nervous system.Progress Neurobiology 65:289-308.
GRABOWSKI,P.J,S.R.SEILER and P.A.SHARP,1985 A multicomponent complex is involved in the splicing of messenger RNA precursors.Cell 42:345-353.
GRAVELY,B.R.,2000 Sorting out the complexity of SR proteins.RNA 6:1197-1211.
GRAVELY,B.R.,2001 Alternative splicing:increasing diversity in the proteomic world.Trends Genetics 17:100-107.
GUI,J.F.,W.S.LANE and X.D.FU,1994 A serine kinase regulates intracellular localization of splicing factors in the cell cycle.Nature 369:678-682.
HACHET,O.,and A.EPHRUSSI,2001 Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.Curr Biol 11:1666-1674.
HACKER,S.,and H.KREBBER,2004 Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins.J Biol Chem 279:5049-5052.
HAFEN,E.,K.BASLER,J.E.EDSTROEM and G.M.RUNIN,1987 Sevenless,a cell-specific homeotic gene of Drosophila,encodes a putative transmembrane receptor with a tyrosine kinase domain.Science 236:55-63.
HARRISON,D.A.,2007 Sex determination:controlling the master.Curr Biol 17:R328-330.
HARTENSTEIN,V.,JAN,Y.N.,1992 Studying Drosophila embryogenesis with P-lacZ enhancer trap lines.Rouxs Arch Dev Biol 201:194-220.
HARTMUTH,K.,H.URLAUB,H.P.VORNLOCHER,C.L.WILL,M.GENTZEL et al.,2002Protein composition of human prespliceosomes isolated by a tobramycin affinityselection method.Proc Natl Acad Sci U S A 99:16719-16724.
HEBERLEIN,U.,T.WOLFF and G.M.RUBIN,1993 The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina.Cell 75:913-926.
HEINRICHS,V.,and B.S.BAKER,1995 The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences.EMBO J.14:3987-4000.
HENRIK MOLINA,D.M.H.,NING TANG,SURESH MATHIVANAN AND AKHILESH PANDEY,2007Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.Proc Natl Acad Sci 104:2199-2204.
HIROSE,Y.,and J.L.MANLEY,2000 RNA polymerase Ⅱ and the integration of nuclear events.Genes Dev 14:1415-1429.
HOFMANN,M.,W.RUDY,U.GUNTHERT,S.G.ZIMMER,V.ZAWADZKI et al.,1993 A link between ras and metastatic behavior of tumor cells:ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells.Cancer Res 53:1516-1521.
HOSHIJIMA,K.,A.KOHYAMA,I.WATAKABE,K.INOUE,H.SAKAMOTO et al.,1995Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins.Nucleic Acids Res 23:3441-3448.
HOWELL,B.W.,D.E.H.AFAR,J.LEW,E.M.J.DOUVILLE,P.L.E.ICELEY et al.,1991 STY,a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.Mol.Cell.Biol.11:568-572.
HSIEH,S.L.,and R.D.CAMPBELL,1991 Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase.Biochem J 278(Pt 3):809-816.
HUANG,Y.,and J.A.FISCHER-VIZE,1996 Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease.Development 122:3207-3216.
HUANG,Y.,R.GATTONI,J.STEVENIN and J.A.STEITZ,2003 SR splicing factors serve as adapter proteins for TAP-dependent mRNA export.Mol Cell 11:837-843.
HUANG,Y.,and J.A.STEITZ,2001 Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.Mol Cell 7:899-905.
HUANG,Y.,T.A.YARIO and J.A.STEITZ,2004 A molecular link between SR protein dephosphorylation and mRNA export.Proc Natl Acad Sci U S A 101:9666-9670.
Hughes, J. R., A. M. Meireles, K. H. Fisher, A. Garcia, P. R. Antrobus et al, 2008a A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis. PLos Biology 6: 785-795.
Hughes, J. R., A. M. Meireles, K. H. Fisher, A. Garcia, P. R. Antrobus et al, 2008b A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol 6: e98.
Hughes, S. C., and R. G. Fehon, 2007 Understanding ERM proteins-the awesome power of genetics finally brought to bear. Curr Opin Cell Biol 19: 51-56.
Iborra, F. J., D. A. Jackson and P. R. Cook, 1998 The path of transcripts from extra- nucleolar synthetic sites to nuclear pores: transcripts in transit are concentrated in discrete structures containing SR proteins. J Cell Sci 111(Pt 15): 2269-2282.
Isaksson, A., F. A. Peverali, L. Kockel, M. Mlodzik and D. Bohmann, 1997 The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development. Mech Dev 68: 59-67.
James, P., J. Halladay and E. A. Craig, 1996 Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.
Jamison, S. F., Z. Pasman, J. Wang, C. Will, R. Luhrmann et al, 1995 U1 snRNP- ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Res 23: 3260-3267.
Janssen, G. M., and W. Moller, 1988a Elongation factor 1 beta gamma from Artemia. Purification and properties of its subunits. Eur J Biochem 171: 119-129.
Janssen, G. M. C., and W. Moller, 1988b Elongation factor 1βγ from Artemia: purification and properties of its subunits. Eur. J. Biochem. 171: 119-129.
Janssen, G. M. C., J. Morales, A. Schipper, J.-C. Labbe, O. Mulner-Lorillon et al, 1991 A major substrate of maturation promoting factor identified as elongation factor 1Bγδ in Xenopus laevis. J. Biol. Chem. 266: 14885-14888.
Jarman, A. P., E. H. Grell, L. Ackerman, L. Y. Jan and Y. N. Jan, 1994 Atonal is the proneural gene for Drosophila photoreceptors. Nature 369: 398-400.
Jarman, A. P., Y. Sun, L. Y. Jan and Y. N. Jan, 1995 Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121: 2019-2030.
Jeppesen, M. G., P. Ortiz, W. Shepard, T. G. Kinzy, J. Nyborg et al, 2003 The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. J Biol Chem 278:47190-47198.
Johnson, K. W., and K. A. Smith, 1991 Molecular cloning of a novel human cdc2/CDC28- like protein kinase. J. Biol. Chem. 266: 3402-3407.
Jurica, M. S., and M. J. Moore, 2003 Pre-mRNA splicing: awash in a sea of proteins. Mol Cell 12: 5-14.
Kambouris, N. G., D. J. Burke and C. E. Creutz, 1993 Cloning and genetic characterization of a calcium- and phospholipid-binding protein from Saccharomyces cerevisiae that is homologous to translation elongation factor-1 gamma. Yeast 9: 151- 163.
Kamiie, K., Y. Nomura, S. Kobayashi, H. Taira, K. Kobayashi et al, 2002 Cloning and expression of Bombyx mori silk gland elongation factor 1gamma in Escherichia coli. Biosci Biotechnol Biochem 66: 558-565.
Kamiie, K., H. Taira, K. Kobayashi, T. Yamashita, S. Kidou et al, 1999 Expression of elongation factor 1 beta' in Escherichia coli and its interaction with elongation factor 1 alpha from silk gland. Biosci Biotechnol Biochem 63: 666-671.
KAMIIE,K.,T.YAMASHITA,H.TAIP,A,S.KIDOU and S.EJIRI,2003 Interaction between elongation factors 1beta and 1gamma from Bombyx mori silk gland.Biosci Biotechnol Biochem 67:1522-1529.
KARAGIOSIS,S.A.,and D.F.READY,2004 Moesin contributes an essential structural role in Drosophila photoreceptor morphogenesis.Development 131:725-732.
KARCH,F.,B.WEIFFENBACH,M.PEIFER,W.BENDER,I.DUNCAN et al.,1985 The abdominal region of the bithorax complex.Cell 43:81-96.
KATAOKA,N.,M.D.DIEM,V.N.KIM,J.YONG and G.DREYFUSS,2001 Magoh,a human homolog of Drosophila mago nashi protein,is a component of the splicing-dependent exon-exon junction complex.EMBO J.20:6424-6433.
KAUFMAN,T.C.,R.LEWIS and B.WAKIMOTO,1980 Cytogenetic Analysis of Chromosome 3in DROSOPHILA MELANOGASTER:The Homoeotic Gene Complex in Polytene Chromosome Interval 84a-B.Genetics 94:115-133.
KEISMAN,E.L.,and B.S.BAKER,2001 The Drosophila sex determination hierarchy modulates wingless and decapentaplegic signaling to deploy dachshund sexspecifically in the genital imaginal disc.Development 128:1643-1656.
KEISMAN,E.L.,A.E.CHRISTIANSEN and B.S.BAKER,2001 The sex determination gene doublesex regulates the A/P organizer to direct sex-specific patterns of growth in the Drosophila genital imaginal disc.Dev Cell 1:215-225.
KHOURY,G.,P.GRUSS,R.DHAR and C.J.LAI,1979 Processing and expression of early SV40 mRNA:a role for RNA conformation in splicing.Cell 18:85-92.
KIM,S.,J.KELLNER,C.H.LEE and P.A.COULOMBE,2007 Interaction between the keratin cytoskeleton and eEF1Bg affects protein synthesis in epithelial cells.Nature Struct.Molec.Biol.14:982-983.
KIM,V.N.,and G,DREYFUS,2001 Nuclear mRNA binding proteins couple pre-mRNA splicing and post-splicing events.Mol Cells 12:1-10.
KIM,V.N.,J.YONG,N.KATAOKA,L.ABEL,M.D.DIEM et al.,2001 The Y14 protein communicates to the cytoplasm the position of exon-exon junctions.EMBO J.20:2062-2068.
KIMBLE,J.,and P.SIMPSON,1997 The LIN-12/Notch signaling pathway and its regulation.Annu Rev Cell Dev Biol 13:333-361.
LINZY,T.G.,T.L.RtPMASTER and J.L.WOOLFORD,JR.,1994 Multiple genes encode the translation elongation factor EF-1 gamma in Saccharomyces cerevisiae.Nucleic Acids Res 22:2703-2707.
KNUST,E.,2007 Photoreceptor morphogenesis and retinal degeneration:lessons from Drosophila.Curr Opin Neurobiol 17:541-547.
KOBAYASHI,S.,S.KIDOU and S.EJIRI,2001 Detection and characterization of glutathione S-transferase activity in rice EF-1betabeta'gamma and EF-1gamma expressed in Escherichia coli.Biochem Biophys Res Commun 288:509-514.
KOHTZ,J.D.,S.F.JAMISON,C.L.WILL,P.ZUO,R.LUHRMANN et al.,1994 Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.Nature 368:119-124.
KONARSKA,M.M.,and P.A.SHAPP,1987 Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes.Cell 49:763-774.
KONIG,H.,N.MATTER,R.BADER,W.THIELE and F.MULLER,2007 Splicing segregation:the minor spliceosome acts outside the nucleus and controls cell proliferation.Cell 131:718-729.
KONIG,H.,H.PONTA and P.HERRLICH,1998 Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator.EMBO J.17:2904-2913.
KOONIN,E.V.,A.R.MUSHEGIAN,R.L.TATUSOV,S.F.ALTSCHUL,S.H.BRYANT et al.,1994 Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse,ancient protein superfamily using motif search and structural modeling.Protein Sci 3:2045-2054.
KOPP,A.,I.DUNCAN,D.GODT and S.B.CARROLL,2000 Genetic control and evolution of sexually dimorphic characters in Drosophila.Nature 408:553-559.
KPEBE,A.,and L.RABINOW,2008a Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase,genesis 46:132-143.
KPEBE,A.,and L.RABINOW,2008b Alternative promoter usage generates multiple evolutionarily conserved isoforms of Drosophila DOA kinase.Genesis 46:132-143.
KPEBE,A.,and L.RABINOW,2008c Dissection of darkener of apricot kinase isoform functions in Drosophila.Genetics 179:1973-1987.
KPEBE,A.,and L.RABINOW,2008d Dissection of DOA kinase isoform functions in Drosophila.Genetics 179:1973-1987.
K.RAINER,A.R.,G.C.CONWAY and D.KOZAK,1990 Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.Genes Dev 4:1158-1171.
KRAMER,H.,R.L.CAGAN and S.L.ZIPURSKY,1991 Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.Nature 352:207-212.
KRAMER,S.G.,T.M.JINKS,P.SCHEDL and J.P.GERGEN,1999 Direct activation of Sexlethal transcription by the Drosophila runt protein.Development 126:191-200.
KUHN,D.T.,J.A.MACK,C.DUAN and G.PACKERT,1993 Tumorous-head(tub-1;tuh-3)modulates Abd-B bithorax-complex functions in Drosophila melanogaster.Genetics 133:593-604.
KUMAR,J.P.,and D.F.READY,1995 Rhodopsin plays an essential structural role in Drosophila photoreceptor development.Development 121:4359-4370.
KUMAR,J.P.,M.TIO,F.HSIUNG,S.AKOPYAN,L.GABAY et al.,1998 Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.Development 125:3875-3885.
KUZIORA,M.A.,and W.MCGINNIS,1988 Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions.Embo J 7:3233-3244.
KWIATKOWSKI,A.V.,C.C.GARNER,W.J.NELSON and F.B.GERTLER,2009 Cell autonomous defects in cortical development revealed by two-color chimera analysis.Mol Cell Neurosci.
LANKES,W.T.,and H.FURTHMAYR,1991 Moesin:a member of the protein 4.1-talin-ezrin family of proteins.Proc Natl Acad Sci U S A 88:8297-8301.
LAWRENCE,P.A.,and G.STRUHL,1996 Morphogens,compartments,and pattern:lessons from drosophila? Cell 85:951-961.
LE HIR,H.,and G.R.ANDERSEN,2008 Structural insights into the exon junction complex.Curr Opin Struct Biol 18:112-119.
LE SOURD,F.,S.BOULBEN,R.LE BOUFFANT,P.CORMIER,J.MORALES et al.,2006a eEF1B:At the dawn of the 21st century.Biochim Biophys Acta.1759:13-31.
LE SOURD,F.,S.BOULBEN,R.LE BOUFFANT,P.CORMIER,J.MORALES et al.,2006b eEF1B:At the dawn of the 21st century.Biochim Biophys Acta 1759:13-31.
LECUIT,T.,and S.M.COHEN,1997 Proximal-distal axis formation in the Drosophila leg.Nature 388:139-145.
LEE,C.Y.,E.A.CLOUGH,P.YELLON,T.M.TESLOVICH,D.A.STEPHAN et al.,2003Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila.Curr Biol 13:350-357.
LEE,J.D.,and J.E.TREISMAN,2001 The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc.Development 128:1519-1529.
LEE,K.,C.DU,M.HORN and L.RABINOW,1996 Activity and autophosphorylation of LAMMER protein kinases.J.Biol.Chem.271:27299-27303.
LEHIR,H.,D.GATFIELD,E.IZAURRALDE and M.J.MOORE,2001 The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.EMBO J 20:4987-4897.
LEHIR,H.,E.IZAURRALDE,L.E.MAQUAT and M.J.MooRE,2000a The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.EMBO J.19:6860-6869.
LEHIR,H.,M.J.MOORE and L.E.MAQUAT,2000b Pre-mRNA splicing alters mRNP composition:evidence for stable association of proteins at exon-exon junctions.Genes Dev.14:1098-1108.
LERNER,M.R.,J.A.BOYLE,S.M.MOUNT,S.L.WOLIN and J.A.STEITZ,1980 Are snRNPs involved in splicing? Nature 283:220-224.
LEW,Y.,D.V.JONES,W.M.MARS,D.EVANS,D.BYRD et al.,1992 Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer.Pancreas 7:144-152.
LEWIS,B.P.,R.E.GREEN and S.E.BRENNER,2003 Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans.Proc Natl Acad Sci U S A 100:189-192.
LI,B.X.,A.K.SATOH and D.F.READY,2007 Myosin V,Rab11,and dRipl1 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors.J Cell Biol 177:659-669.
LINDBERG,A.,M.GAMA-CARVALHO,M.CARMO-FONSECA and J.P.KREIVI,2004 A single RNA recognition motif in splicing factor ASF/SF2 directs it to nuclear sites of adenovirus transcription.J Gen Virol 85:603-608.
LINDBERG,R.A.,A.M.QUINN and T.HUNTER,1992 Dual-specificity protein kinases:Will any hydroxyl do? TIBS 17:114-119.
LONG,J.C.,and J.F.CACERES,2009 The SR protein family of splicing factors:master regulators of gene expression.Biochem J 417:15-27.
LONGLEY,R.L.,JR.,and D.F.READY,1995 Integrins and the development of threedimensional structure in the Drosophila compound eye.Dev Biol 171:415-433.
LONGMAN,D.,I.L.JOHNSTONE and J.F.CACERES,2000 Functional characterization of SR and SR-related genes in Caenorhabditis elegans.EMBO J 19:1625-1637.
LONGMAN,D.,T.MCGARVEY,S.MCCRACKEN,I.L.JOHNSTONE,B.J.BLENCOWE et al.,2001 Multiple interactions between SRm160 and SR family proteins in enhancerdependent splicing and development of C.elegans.Curr Biol 11:1923-1933.
LOPEZ,A.J.,1998 Alternative splicing of pre-mRNA:developmental consequences and mechanisms of regulation.Aunu Rev Genet 32:279-305.
MADHAVAN,M.M.A.S.,H.A.,1977 Histological analysis of the dynamics of growth of imaginal discs and histoblasts nests during the larval development of Drosophila melanogaster.Rouxs Arch Dev Biol 183.
MANIATIS,T.,and B.TASIC,2002 Alternative pre-mRNA splicing and proteome expansion in metazoans.Nature 418:236-243.
MANSILLA,F.,I.FRIIS,M.JADIDI,K.M.NIELSEN,B.F.CLARK et al.,2002 Mapping the human translation elongation factor eLF1H complex using the yeast two-hybrid system.Biochem J 365:669-676.
MAQUAT,L.E.,2004 Nonsense-mediated mRNA decay:splicing,translation and mRNP dynamics.Nat Rev Mol Cell Biol 5:89-99.
MATHUR,S.,K.R.CLEARY,N.INAMDAR,Y.H.KIM,P.STECK et al.,1998 Overexpression of elongation factor-1 gamma protein in colorectal carcinoma.Cancer 82:816- 821.
MATLIN,A.J.,and M.J.MOORE,2007 Spliceosome assembly and composition.Adv Exp Med Biol 623:14-35.
MAYEDA,A.,G.R.SCREATON,S.D.CHANDLER,X.D.Fu and A.R.KRAINER,1999Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements.Mol Cell Biol 19:1853-1863.
MCCRACKEN,S.,M.LAMBERMON and B.J.BLENCOWE,2002 SRm160 splicing coactivator promotes transcript 3'-end cleavage.Mol Cell Biol 22:148-160.
MCCRACKEN,S.,D.LONGMAN,I.L.JOHNSTONE,J.F.CACERES and B.J.BLENCOWE,2003An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.J Biol Chem 278:44153-44160.
MCCRACKEN,S.,D.LONGMAN,E.MARCON,P.MOENS,M.DOWNEY et al.,2005 Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.J Biol Chem 280:42227-42236.
MCCULLOUGH,A.J.,and S.M.BERGET,2000 An intronic splicing enhancer binds U1snRNPs to enhance splicing and select 5' splice sites.Mol Cell Biol 120:9225-9235.
MCGARVEY,T.,E.ROSONINA,S.MCCRACKEN,Q.LI,R.ARNAOUT et al.,2000 The acute myeloid leukemia-associated protein,DEK,forms a splicing-dependent interaction with exon-product complexes.J.Cell Biol.150:309-320.
MEISSNER,M.,S.LOPATO,J.GOTZMANN,G.SAUERMANN and B.A,2003 Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB,SRm160,and SR proteins.Exp Cell Res.283:184-195.
MENEGAY,H.J.,M.P.MYERS,F.M.MOESLEIN and G.E.LANDRETH,2000 Biochemical characterization and localization of the dual specificity kinase CLK1.J.Cell Science 113:3241-3253.
MERMOUD,J.E.,P.T.W.COHEN and A.I.LAMOND,1994 Regulation of mammalian spliceosome assembly by a protein phsophorylation mechanism.EMBO J.13:5679-5688.
MERRICK,W.C.,and J.NYBORG(Editors),2000 The protein synthesis elongation cycle.CSHL Press,Cold Spring Harbor,N.Y.
MIMORI,K.,M.MoP,I,H.INOUE,H.UEO,K.MAFUNE et al.,1996 Elongation factor 1 gamma mRNA expression in oesophageal carcinoma.Gut 38:66-70.
MIMORI,K.,M.MORI,S.TANAKA,T.AKIYOSHI and K.SUGIMACHI,1995a The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.Cancer 75:1446-1449.
MIMORI,K.,M.MORI,S.TANAKA,T.AKIYOSHI and K.SUGIMACHI.1995b The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.Cancer 75:1446-1449.
MINELLA,O.,O.MULNER-LORILLON,V.DE SMEDT,S.HOURDEZ,P.CORMIER et al.,1996Major intracellular localization of elongation factor-1.Cell Mol Biol(Noisy-le-grand)42:805-810.
MINTZ,P.J.,S.O.PATTERSON,A.F.NEUWALD,C.S.SPAHR and D.L.SPECTOR,1999Purification and biochemical characterization of interchromatin granule clusters.EMBO J.18:4308-4320.
MISTELI,T.,1999 RNA splicing:What has phosphorylation got to do with it? Curr.Biol.9:R198-200.
MISTELI,T.,and D.L.SPECTOR,1999 RNA polymerase Ⅱ targets pre-mRNA splicing factors to transcription sites in vivo.Mol Cell 3:697-705.
MITROVICH,Q.M.,and P.ANDERSON,2000 Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C.elegans.Genes Dev 14:2173-2184.
MOESLEIN,F.M.,M.P.MYERS and G.E.LANDRETH,1999 The CLK family kinases CLK1and CLK2 phosphoryate and activate the tyrosine phosphatase PTP-1B.J.Biol.Chem.274:26697-26704.
MOHR,S.E.,S.T.DILLON and R.E.BOSWELL,2001 The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis.Genes Dev 15:2886-2899.
MONNIER,A.,R.BELLE,J.MORALES,P.CORMIER,S.BOULBEN et al.,2001 Evidence for regulation of protein synthesis at the elongation step by CDK1/cyclin B phosphorylation.Nucleic Acids Res 29:1453-1457.
MORALES,J.,P.CORMIER,O.MULNER-LORILLON,R.POULHE and R.BELLE,1992 Molecular cloning of anew guanine nucleotide-exchange protein,EF1 delta.Nucleic Acids Res 20:4091.
MORANTE,J.,C.DESPLAN and A,CELIK,2007 Generating patterned arrays of photoreceptors.Curr Opin Genet Dev 17:314-319.
MORRJS,J.Z.,C.NAVARRO and R.LEHMANN,2003 Identification and analysis of mutations in bob,Doa and eight new genes required for oocyte specification and development in Drosophila melanogaster.Genetics 164:1435-1446.
MORRISON,H.,L.S.SHERMAN,J.LEGG,F.BANINE,C.ISACKE et al.,2001 The NF2 tumor suppressor gene product,merlin,mediates contact inhibition of growth through interactions with CD44.Genes Dev 15:968-980.
MOTOYOSHI,K.,and K.IWASAKI,1977 Resolution of the polypeptide chain elongation factor-1 beta gamma into subunits and some properties of the subunits.J Biochem 82:703-708.
MULNER-LORILLON,O.,P.CORMIER,J.CAVADORE,J.MORALES,R.POULHE et al.,1992a Phosphorylation of Xenopus elongation factor-1γ by cdc2 protein kinase:identification of the phosphorylation site.Exp.Cell Res.202:549-551.
MULNER-LORILLON,O.,P.CORMIER,J.C.CAVADORE,J.MORALES,R.POULHE et al.,1992b Phosphorylation of Xenopus elongation factor-1 gamma by ode2 protein kinase:identification of the phosphorylation site.Exp Cell Res 202:549-551.
MURAKAMI.K.,S.EJIRI and T.KATSUMATA,1978 Elongation factor 1 from the silk gland of silkworm.Effect of EF-1b on EF-1a-and ribosome-dependent GTPase activity.FEBS Lett 92:255-257.
NAGOSHI,R.N.,and B.S.BAKER,1990 Regulation of sex-specific RNA splicing at the Drosophila doublesex gene:cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.Genes Dev.4:89-97.
NAGOSHI,R.N.,M.MCKEOWN,K.C.BURTIS,J.M.BELOTE and B.S.BAKER,1988 The control of alternative splicing at genes regulating sexual differentiation in D.melanogaster.Cell 53:229-236.
NAYLER,O.,F.SCHNORRER,S.STAMM and A.ULLRICH,1998 The cellular localization of the mutine Serine/Arginine-rich protein kinase CLK2 is regulated by Serine 141autophosphorylation.J.Biol.Chem.273:34341-34348.
NAYLER,O.,S.STAMM and A.ULLRICH,1997a Characterization and comparison of four serine- and arginine-rich(SR) protein kinases.Biochem.J.326:693-700.
NAYLER,O.,S.STAMM and A.ULLRICH,1997b Characterization and comparison of four serine- and arginine-rich(SR) protein kinases.Biochem J 326(Pt 3):693-700.
NGO,J.C.,S.CHAKRABARTI,J.H.DING,A.VELAZQUEZ-DONES,B.NOLEN et al.,2005Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.Mol Cell 20:77-89.
NIKOLAKAKI,E.,C.DU,J.LAI,L.CANTLEY,T.GIANNAKOUROS et al.,2002 Phosphorylation by LAMMER protein kinases:determination of a consensus site,identification of in vitro substrates and implications for substrate preferences.Biochemistry 41:2055-2066.
N(O|¨)THIGER,R.,D(U|¨)BENDORFER,A.,EPPER,F.,1977 Gynandromorphs reveal two separate primordia for male and female genitalia.Rouxs Arch.Dev.Biol.181:367-373.
O'CONNELL,P.O.,and M.ROSBASH,1984 Sequence,structure and codon preference of the Drosophila ribosomal protein 49 gene.Nucl.Acid.Res.12:5495-5513.
OHNO,M.,and Y.SHIMURA,1996 A human RNA helicase-like protein,HRH1,facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.Genes Dev 10:997-1007.
OLAREWAJU,O.,P.A.ORTIZ,W.Q.CHOWDHURY,I.CHATTERJEE and T.G.KINZY,2004a The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.RNA Biol 1:89-94.
OLAREWAJU,O.,P.A.ORTZ,W.Q.CHOWDHURY,I.CHATTERJEE and T.G.KINZY,2004b The translation elongation factor eEF1B plays a role in the oxidative stress response pathway.RNA Biology 1:e12-e17.
ORIAN-ROUSSEAU,V.,L.CHEN,J.P.SLEEMAN,P.HERRLICH and H.PONTA,2002 CD44 is required for two consecutive steps in HGF/c-Met signaling.Genes Dev 16:3074-3086.
PADMANABHA,R.,S.GEHRUNG and M.SNYDER,1991 The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family.Mol.Gen.Genet.229:1-9.
PAPAVASSILIOU,A.G.,and D.BOHMANN,1992 Dephosphorylation of phosphoproteins with potato acid phosphatase.Meth.Molec.Cell.Biol.3:149-152.
PARKER,R.,P.G.SILICIANO and C.GUTHRIE,1987 Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.Cell 49:229-239.
PARKHURST,S.M.,and D.ISH-HOROWICZ,1992 Common denominators for sex.Curr Biol 2:629-631.
PEREZ,J.M.,J.KRIEK,J.DIJK,G.W.CANTERS and W.MOLLER,1998 Expression,purification,and spectroscopic studies of the guanine nucleotide exchange domain of human elongation factor,EF-1beta.Protein Expr Purif 13:259-267.
PEREZ,J.M.,G.SIEGAL,J.KRIEK,K.HARD,J.DIJK et al.,1999 The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli.Structure 7:217-226.
PETERS,H.L,Y.W.CHANG and J.A.TRAUGH,1995 Phosphorylation of elongation factor 1(EF-1) by protein kinase C stimulates GDP/GTP-exchange activity.Eur J Biochem 234:550-556.
PINAL,N.,D.C.GOBERDHAN,L.COLLINSON,Y.FUJITA,I.M.COX et al.,2006 Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.Curr Biol 16:140-149.
POMERENING,J.R.,L.VALENTE,T.G.KINZY and T.W.JACOBS,2003 Mutation of a conserved CDK site converts a metazoan Elongation Factor 1Bbeta subunit into a replacement for yeast eEF1Balpha.Mol Genet Genomics 269:776-788.
PONTA,H.,L.SHERMAN and P.A.HERRLICH,2003 CD44:from adhesion molecules to signalling regulators.Nat Rev Mol Cell Biol 4:33-45.
PRASAD,J.,K.COLWILL,T.PAWSON and J.L.MANLEY,1999 The protein kinase Clk/Sty directly modulates SR protein activity:both hyper- and hypophosphorylation inhibit splicing.Mol Cell Biol 19:6991-7000.
PRASAD,J.,and J.L.MANLEY,2003 Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty.Molec.Cell.Biol.23:4139-4149.
RABINOW,L.,and J.A.BIRCHLER,1989 A dosage-sensitive modifier of retrotransposon induced alleles of the Drosophila white locus.EMBO J.8:879-889.
RABINOW,L.,S.L.CHIANG and J.A.BIRCHLER,1993 Mutations at the Darkener of apricot locus modulate transcript levels of copia and copia-induced mutations in Drosophila melanogaster.Genetics 134:1175-1185.
READY,D.F.,T.E.HANSON and S.BENZER,1976 Development of the Drosophila retina,a neurocrystalline lattice.Dev Biol 53:217-240.
REED,R.,1996 Initial splice-site recognition and pairing during pre-mRNA splicing.Curr Opin Genet Dev 6:215-220.
REED,R.,2003 Coupling transcription,splicing and mRNA export.Curr Opin Cell Biol 15:326-331.
RIIS,B.,.S.I.S.RATTAN,B.F.C.CLARK and W.C.MERRICK,1990 Eukaryotic protein elongation factors.Trends Biol.Chem.15:420-424.
ROMEO,Y.,and B.LEMAITRE,2008 Drosophila immunity:methods for monitoring the activity of Toll and Imd signaling pathways.Methods Mol Biol.415:379-394.
ROOKE,J.E.,and T.XU,1998 Positive and negative signals between interacting cells for establishing neural fate.Bioessays 20:209-214.
ROSCIGNO,R.F.,and M.A.GARCIA-BLANCO,1995 SR proteins escort the U4/U6.U5 trisnRNP to the spliceosome.Rna 1:692-706.
ROTH,M.B.,C.MURPHY and J.G.GALL,1990 A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.J Cell Biol 111:2217-2223.
ROTTMAN,F.,A.J.SHATKIN and R.P.PERRY,1974 Sequences containing methylated nucleotides at the 5'termini of messenger RNAs:possible implications for processing.Cell 3:197-199.
RYNER,L.C.,S.F.GOODWIN,D.H.CASTRILLON,A.ANAND,A.VILLELLA et al.,1996Control of male sexual behavior and sexual orientation In Drosophila by the fruitless gene.Cell 87:1079-1089.
SACCO-BUBULYA,P.,and D.L.SPECTOR,2002 Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing.J Cell Biol 156:425-436.
SANCHEZ,L.,CASARES,F.,GORFINKIEL,N.AND GUERRERO,I.,1997 The genital disc of Drosophila melanogaster.Ⅱ.Role of the genes hedgehog,decapentaplegic and wingless.Dev Genes Evol 207:229-241.
SANCHEZ,L.,N.GORFINKIEL and I.GUERRERO,2001 Sex determination genes control the development of the Drosophila genital disc,modulating the response to Hedgehog,Wingless and Decapentaplegic signals.Development 128:1033-1043.
SANCHEZ-HERRERO,E.,I.VERNOS,R.MARCO and G.MORATA,1985 Genetic organization of Drosophila bithorax complex.Nature 313:108-113.
SANDERS,J.,M.BRANDSMA,G.M.JANSSEN,J.DIJK and W.MOLLER,1996Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum.J Cell Sci 109(Pt 5):1113-1117.
SANDERS,J.,R.RAGGIASCHI,J.MORALES and W.MOLLER,1993 The human leucine zippercontaining guanine-nucleotide exchange protein elongation factor-1 delta.Biochim Biophys Acta 1174:87-90.
SANFORD,J.R.,and J.P.BRUZIK,1999 Developmental regulation of SR protein phosphorylation and activity.Genes Dev 13:1513-1518.
SANFORD,J.R.,and J.P.BRUZIK,2001a Regulation of SR protein localization during development.Proc Natl Acad Sci U S A 98:10184-10189.
SANFORD,J.R.,and J.P.BRUZIK,2001b Regulation of SR protein localization during development.Proc Natl Acad Sci U S A 98:10184-10189.
SANFORD,J.R.,D.LONGMAN and J.F.CACERES,2003 Multiple roles of the SR protein family in splicing regulation.Prog Mol Subcell Biol 31:33-58.
SATOH,A.K.,J.E.O'TOUSA,K.OZAKI and D.F.READY,2005 Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors.Development 132:1487-1497.
SAVALDI-GOLDSTEIN,S.,G.SESSA and R.FLUHR,2000 The ethylene-inducible PK12 kinase mediates the phosphorylation of SR splicing factors.Plant Journ.21:91-96.
SCHAAL,T.D.,and T.MANIATIS,1999 Selection and characterization of pre-mRNA splicing enhancers:identification of novel SR protein-specific enhancer sequences.Mol Cell Biol 19:1705-1719.
SCHULTZ,J.,T.JONES,P.BORK,D.SHEER,S.BLENCKE et al.,2001 Molecular characterization of a cDNA encoding functional human CLK4 kinase and localization to chromosome 5q35[correction of 4q35].Genomics 71:368-370.
SCH(U|¨)PBACH,T.,WIESCHAUS,E.,N(O|¨)THIGER,R.,1978 The embryonic organization of the genital disc studied in genetic mosaics of Drosophila melangaster.Rouxs Arch.Dev.Biol.185:249-270.
SCHUTT,C.,and R.NOTHIGER,2000 Structure,function and evolution of sex-determining systems in Dipteran insects.Development 127:667-677.
SCHWEITZER,R.,R.HOWES,R.SMITH,B.Z.SHILO and M.FREEMAN,1995 Inhibition of Drosophila EGF receptor activation by the secreted protein Argos.Nature 376:699-702.
SCIABICA,K.S.,Q.J.DAI and R.M.SANDRI-GOLDIN,2003 ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation.Embo J 22:1608-1619.
SEFTON,L.,J.R.TIMMER,Y.ZHANG,F.BERANGER and T.W.CLINE,2000 An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element.Nature 405:970-973.
SEIF,I.,G.KHOURY and R.DHAR,1979 BKV splice sequences based on analysis of preferred donor and acceptor sites.Nucleic Acids Res 6:3387-3398.
SERRANO,N.,and P.H.O'FARRELL,1997 Limb morphogenesis:connections between patterning and growth.Curr Biol 7:R186-195.
SESSA,G.,V.RAZ,S.SAVALDI and R.FLUHR,1996 PK12,a plant dual-specificity protein kinase of the LAMMER family,is regulated by the hormone ethylene.Plant Cell 8:2223-2234.
SHARP,P.A.,1994 Split genes and RNA splicing.Cell 77:805-815.
SHEAR.N,A.,and A.GAREN,1974 Genetic control of imaginal disc development in Drosophila.Proc Natl Acad Sci U S A 71:1393-1397.
SHEN,H.,and M.R.GREEN,2004 A pathway of sequential arginine-serine-rich domainsplicing signal interactions during mammalian spliceosome assembly.Mol Cell 16:363-373.
SHEN,H.,and M.R.GREEN,2006 RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans.Genes Dev 20:1755-1765.
SHEN,H.,J.L.KAN and M.R.GREEN,2004 Arginine-serine-rich domains bound at splicing enhancers contact the branchpoint to promote prespliceosome assembly.Mol Cell 13:367-376.
SHEU,G.T.,and J.A.TRAUGH,1997 Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli.Subunit interactions,elongation activity,and phosphorylation by protein kinase CKII.J Biol Chem 272:33290-33297.
SHI,Y.,D.C.DI GIAMMARTINO,D.TAYLOR,A.SARKESHIK,W.J.RICE et al.,2009Molecular architecture of the human pre-mRNA 3' processing complex.Mol Cell 33:365-376.
SHIN,C.,Y.FENG and J.L.MANLEY,2004 Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.Nature 427:553-558.
SHIN,C.,and J.L.MANLEY,2002 The SR protein SRp38 represses splicing in M phase cells.Cell 111:407-417.
SLOBIN,L.I.,and W.MOLLER,1978 Purification and properties of an elongation factor functionally analogous to bacterial elongation factor Ts from embryos of Artemia salina.Eur.J.Biochem.84:69-77.
SOSNOWSKI,B.A.,J.M.BELOTE and M.MCKEOWN,1989 Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage.Cell 58:449-459.
STAFFA,A.,and A.COCHRANE,1995 Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1.Mol Cell Biol 15:4597-4605.
STANYON,C.A.,G.LIU,B.A.MANGIOLA,N.PATEL,L.GIOT et al.,2004 A Drosophila protein-interaction map centered on cell-cycle regulators.Genome Biol 5:R96.
STAUDINGER,J.,M.PERRY,S.J.ELLEDGE and O.E.N.,1993 Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system.J.Biol.Chem.268:4608-4611.
STEINMANN-ZWICKY,M.,H.AMREIN and R.NOTHIGER,1990 Genetic control of sex determination in Drosophila.Adv Genet 27:189-237.
STEVENS,S.W.,D.E.RYAN,H.Y.GE,R.E.MOORE,M.K.YOUNG et al.,2002Composition and functional characterization of the yeast spliceosomal penta-snRNP.Mol Cell 9:31-44.
STOKS,M.P.,J.RUSH,J.MACNEILL,J.M.REN,K.SPROTT et al.,2007 Profiling of UV-induced ATM/ATR signaling pathways.Proc Natl Aead Sci U S A 104:19855-19860.
STRUTT,D.I.,V.WIERSDORFF and M.MLODZIK,1995 Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A.Nature 373:705-709.
STRUTT,H.,and D.STRUTT,2003 EGF signaling and ommatidial rotation in the Drosophila eye.Curr Biol 13:1451-1457.
STUART,L.M.,J.BOULAIS,G.M.CHARRIERE,E.J.HENNESSY,S.BRUNET et al.,2007a A systems biology analysis of the Drosophila phagosome.Nature 445:95-101.
STUART,L.M.,J.BOULAIS,G.M.CHARRIERE,E.J.HENNESSY,S.BRUNET et al.,2007b A systems biology analysis of the Drosophila phagosome.Nature 445:95-101.
SUREAU,A.,R.GATTONI,Y.DOOGHE,J.STEVENIN and J.SORET,2001 SC35 autoregnlates its expression by promoting splicing events that destabilize its mRNAs.Embo J 20:1785-1796.
SZYMCZYNA,B.R.,J.BOWMAN,S.MCCRACKEN,A.PINEDA-LUCENA,Y.Lu et al.,2003Structure and function of the PWI motif:a novel nucleic acid-binding domain that facilitates pre-mRNA processing.Genes Dev 17:461-475.
T. WOLFF, D. F. R., 1993 The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, N. Y.
Tacke, R., and J. L. Manley, 1999 Determinants of SR protein specificity. Curr Opin Cell Biol 11: 358-362.
Talmadge, K., S. Finkernagel, L. Sciorra, J. Sumegi and L. Rabinow, 1998 Chromosomal mapping of three human LAMMER protein kinase-encoding genes. Human Genetics 103: 523-524.
Tang, Z., T. Kuo, J. Shen and R. J. Lin, 2000 Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol Cell Biol 20: 816- 824.
Tang, Z., A. Tsurumi, S. Alaei, C. Wilson, C. Chiu et al, 2007 Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast. Biochem J 405: 21-30.
Tange, T. O., A. Nott and M. J. Moore, 2004 The ever-increasing complexities of the exon junction complex. Curr Opin Cell Biol 16: 279-284.
TAUTZ, D., and C. Pfeifle, 1989 A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98: 81-85.
Taylor, B. J., A. Villella, L. C. Ryner, B. S. Baker and J. C. Hall, 1994 Behavioral and neurobiological implications of sex-determining factors in Drosophila. Dev Genet 15: 275-296.
Tepass, U., and K. P. Harris, 2007 Adherens junctions in Drosophila retinal morphogenesis. Trends Cell Biol 17: 26-35.
Tian, M., and T. Maniatis, 1993 A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74: 105-114.
Tintaru, A. M., G. M. Hautbergue, A. M. Hounslow, M. L. Hung, L. Y. Lian et al, 2007 Structural and functional analysis of RNA and TAP binding to SF2/ASF. EMBO Rep 8: 756-762.
Tio, M., and K. Moses, 1997 The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina. Development 124: 343-351.
Tokumoto, T., A. Kondo, J. Miwa, R. Horiguchi, M. Tokumoto et al, 2003 Regulated interaction between polypeptide chain elongation factor-1 complex with the 26S proteasome during Xenopus oocyte maturation. BMC Biochem 4: 6.
Tomlinson, A., and D. F. Ready, 1987 Cell fate in the Drosophila ommatidium. Dev. Biol. 123: 264- 275.
Tomlinson, A., and G. Struhl, 2001 Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor. Mol Cell 7: 487-495.
Tomlinson, G. C. a. A., 1995 Initiation of the proximodistal axis in insect legs. Development 121: 619-628.
Treisman, J. E., and G. M. Rubin, 1995 wingless inhibits morphogenetic furrow movement in the Drosophila eye disc. Development 121: 3519-3527.
van Buskirk, C., and T. Schupbach, 1999 Versatility in signalling: multiple responses to EGF receptor activation during Drosophila oogenesis. Trends Cell Biol. 9: 1-4.
van Damme, H., R. Amons, G. Janssen and W. Moller, 1991 Mapping the functional domains of the eukaryotic elongation factor 1 beta gamma. Eur J Biochem 197: 505- 511.
van Damme, H. T., R. Amons, R. Karssies, C. J. Timmers, G. M. Janssen et al, 1990 Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta. Biochim Biophys Acta 1050: 241-247.
VANWETSWrNKEL,S.,J.KRIEK,G.R.ANDERSEN,P.GUNTERT,J.DIJK et al.,2003 Solution structure of the 162 residue C-terminal domain of human elongation factor 1Bgamma.J Biol Chem 278:43443-43451.
VENEMA,,R.C.,H.I.PETERS and J.A.TRAUGH,1991 a Phosphorylation of elongation factor 1(EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1activity.J Biol Chem 266:12574-12580.
VENEMA,R.C.,H.I.PETERS and J.A.TRAUGH,1991b Phosphorylation of valyl-tRNA synthetase and elongation factor 1 in response to phorbol esters is associated with stimulation of both activities.J Biol Chem 266:11993-11998.
VOAS,M.G.,and I.REBAY,2004 Signal integration during development:insights from the Drosophila eye.Dev Dyn 229:162-175.
YON STEIN,W.,A.RAMRATH,A.GRIMM,M.MULLER-BORG and A.WODARZ,2005 Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling.Development 132:1675-1686.
W.C.MERRICK,J.N.,2000 The protein synthesis elongation cycle,pp.89-125 in Translational Control of Gene Expression,edited by J.H.N.SONENBERG,M.MATHEWS.CSHL Press,New York.
WAGNER,S.,S.CHIOSEA,M.IVSHINA and J.A.NICKERSON,2004 In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160.J Cell Biol 164:843-850.
WAGNER,S.,S.CHIOSEA and J.A.NICKERSON,2003 The spatial targeting and nuclear matrix binding domains of SRm160.Proc.Natl.Acad.Sci.100:3269-3274.
WAN,K.M.,J.A.NICKERSON,G.KROCKMALNIC and S.PENMAN,1994 The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis.Proc.Natl.Acad.Sci.USA 91:594-598.
WANG,H.Y.,W.LIN,J.A.DYCK,J.M.YEAKLEY,Z.SONGYANG et al.,1998 SRPK2:a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.J.Cell Biol.140:737-750.
WANG,J.,P.J.SMITH,A.R.KRAINER and M.Q.ZHANG,2005 Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes.Nucleic Acids Res 33:5053-5062.
WANG,Z.,and C.B.BURGE,2008 Splicing regulation:from a parts list of regulatory elements to an integrated splicing code.Rna 14:802-813.
WASSARMAN,D.A.,M.THERRIEN and G.M.RUBIN,1995 The Ras signaling pathway in Drosophila.Curr Opin Genet Dev 5:44-50.
WATKINS-CHOW,D.E.,K.R.DOUGLAS,M.S.BUCKWALTER,F.J.PROBST and S.A.CAMPER,1997 Construction of a 3-Mb contig and partial transcript map of the central region of mouse chromosome 11.Genomics 45:147-157.
WEAVER,T.A.,and R.A.WHITE,1995 headcase,an imaginal specific gene required for adult morphogenesis in Drosophila melanogaster.Development 121:4149-4160.
WIERSDORFF,V.,T.LECUIT,S.M.COHEN and M.MLODZIK,1996 Mad acts downstream of Dpp receptors,revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye.Development 122:2153-2162.
WIESCHAUS,E.,and R.NOTHIGER,1982 The role of the transformer genes in the development of genitalia and analia of Drosophila melanogaster.Dev Biol 90:320-334.
WOLFF,T.,2003 EGF receptor signaling:putting a new spin on eye development.Curr Biol 13:R813-814.
Wolff, T., and D. F. Ready, 1993 The Development of Drosophila melanogaster. Cold Spring Harbor Laboratory Press, N. Y.
Wu, J. Y., and T. Maniatis, 1993 Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75:1061-1070.
Xiao, S. H., and J. L. Manley, 1997 Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev 11: 334-344.
Xiao, S. H., and J. L. Manley, 1998 Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. Embo J 17: 6359-6367.
Xu, T., and G. M. Rubin, 1993 Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
Yaffe, M. B., G. G. Leparc, J. Lai, T. Obata, S. Volinia et al, 2001 A motif-based scanning approach for genome-wide prediction of signaling pathways. Nature Biotech. 19: 348-353.
Yang, L., and N. E. Baker, 2003 Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev Cell 4: 359-369.
Yang, L., and N. E. Baker, 2006 Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye. BMC Dev Biol 6: 8.
Yang, Y., W. Zhang, J. R. Bayrer and M. A. Weiss, 2008 Doublesex and the regulation of sexual dimorphism in Drosophila melanogaster: structure, function, and mutagenesis of a female-specific domain. J Biol Chem 283: 7280-7292.
Yeo, G., S. Hoon, B. Venkatesh and C. B. Burge, 2004 Variation in sequence and organization of splicing regulatory elements in vertebrate genes. Proc Natl Acad Sci U S A 101:15700-15705.
Yun, B., R. Farkas, K. Lee and L. Rabinow, 1994 The Doa locus encodes a member of a new protein kinase family, and is essential for eye and embryonic development in Drosophila melanogaster. Genes Dev. 8: 1160-1173.
Yun, B., K. Lee, R. Farkas, C. Hitte and L. Rabinow, 2000a The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells, and is expressed as both nuclear and cytoplasmic isoforms throughout development. Genetics 156: 749-761.
Yun, B., K. Lee, R. Farkas, C. Hitte and L. Rabinow, 2000b The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells and is expressed as both nuclear and cytoplasmic isoforms throughout development. Genetics 156: 749-761.
Yun, C. Y., and X. D. Fu, 2000 Conserved SR Protein Kinase Functions in Nuclear Import and Its Action Is Counteracted by Arginine Methylation in Saccharomyces cerevisiae. J. Cell Biology 150:707-718.
Yun, C. Y., A. L. Velazquez-Dones, S. K. Lyman and X. D. Fu, 2003 Phosphorylation- dependent and -independent nuclear import of RS domain-containing splicing factors and regulators. J Biol Chem 278:18050-18055.
Zahler, A. M., W. S. Lane, J. A. Stolk and M. B. Roth, 1992 SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev 6: 837-847.
Zavortink, M., and S. Sakonju, 1989 The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters. Genes Dev 3: 1969-1981.
Zhai, B., J. Villen, S. A. Beausoleil, J. Mintseris and S. P. Gygi, 2008 Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res 7: 1675-1682.
ZHENG,Z.M.,2004 Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression.J Biomed Sci 11:278-294.
ZHOU,Z.,L.J.LICKLIDER,S.P.GYGI and R.REED,2002 Comprehensive proteomic analysis of the human spliceosome.Nature 419:182-185.
ZHOU,Z.,and R.REED,1998 Human homologs.of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step Ⅱ of pre-mRNA splicing.Embo J 17:2095-2106.
ZHU,L.,J.WILKEN,N.B.PHILLIPS,U.NARENDRA,G.CHAN et al.2000 Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers.Genes Dev 14:1750-1764.