影响水稻中LRR受体蛋白激酶类R基因抗性特异性及生育期相关抗性的因子解析
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摘要
水稻白叶枯病是由黄单胞杆菌水稻致病变种(Xanthomonas oryzae pv.oryzae,Xoo)引起的一种细菌性维管束病害,是水稻生产上的重要病害之一。水稻是不仅是重要的粮食作物,也作为单子叶植物和谷类作物研究的一种模式植物。而随着多越来越多个水稻抗白叶枯病基因的克隆以及白叶枯菌基因组序列的完成,水稻抗白叶枯病的研究已经称为研究植物与微生物互作关系的一种模式。因此,不论从生产上还是从基础理论研究上,对水稻对白叶枯抗病机理进行深入和广泛的研究,从分子和遗传水平解释其机理都具有重要意义。
Xa3/Xa26和Xa21是水稻中两个广谱的抗白叶枯病基因,它们都编码富亮氨酸重复类受体蛋白激酶,也都是属于基因家族成员。然而,它们具有不同的小种特异性,Xa21抗PXO99而Xa3/Xa26感PXO99。此外,Xa21的功能还受到不同生育期的影响。IRBB21对PXU99的抗性会随着植株的发育逐步增强,表现为从2叶期的感病到9-10叶期的完全抗病。而在牡丹江8中表达的Xa3/Xa26对PXO61表现全生育期抗性。
我们构建了包含编码XA21与XA26不同结构域序列的嵌合基因,将它们以及Xa21都转到同样的品种牡丹江8中,在相同背景下考察它们的抗性,抗谱以及在不同生育期时的抗性,解释了该类蛋白各个结构与功能的关系。另外,利用酵母双杂交的方法,筛选与XA3/XA26激酶结构互作的蛋白,寻找参与XA3/XA26介导的抗病反应的蛋白。
D56S编码产物包含XA3/XA26的富亮氨酸重复区和跨膜区以及XA21的激酶结构域;D57S编码产物包含XA21的富亮氨酸重复区和跨膜区以及XA3/XA26的激酶结构域。抗谱分析表明,D56S与D57S的抗谱分别与Xa3/Xa26和Xa21相似。与D56S或D57S只在胞内近膜区编码序列有差异的D52S和D92S则对所有试验菌株都不提供抗性。这些表明富亮氨酸重复区决定了XA21和XA3/XA26对白叶枯菌的小种特异性,而且XA21与XA3/XA26可能具有相同的下游抗病信号传导途径。另外,我们的结果也表明近膜区也能影响该类抗病蛋白的抗性特异性。
在2叶期,4叶期,分蘖盛期,孕穗期以及始穗期对转基因材料和各种携带Xa3/Xa26或者Xa21的材料接种白叶枯菌PXO61,PXO99和PXO341。结果显示,在牡丹江8背景下,D56S,D57S,Xa21与Xa3/Xa26一样,对PXO61具有全生育期抗性。而在IR24背景或者明恢63背景下,Xa21和Xa3/Xa26只表现出成株期抗性。不同材料中Xa21和Xa3/Xa26对PXO99或PXO341的抗性也同样如此。这些都表明Xa21或Xa3/Xa26在不同生育期的抗性差异只是受到遗传背景的影响,而非他们的结构上的差异。实时定量PCR结果显示,在IRBB21中,Xa21的表达量随着植株生长逐渐增强,这与IRBB21从苗期到成株期对白叶枯菌的抗性变化相一致。与IRBB21相比,转Xa21基因牡丹江中Xa21的表达量在不同生育期都显著增强。此外,不论是转基因植株还是IRBB21,Xa21的表达量都在分蘖盛期最高,在此生育期是与Xa21在提供的抗性也最强,说明Xa21的功能具有剂量效应,转基因牡丹江8植株中高水平的Xa21也提供了对白叶枯菌的苗期抗性。
用XA3/XA26的激酶区段筛选到3个在明恢63中与之互作的蛋白。其中,D4是mRNA剪接因子,C5是一个自吞噬相关蛋白,而C17是G蛋白的一个β亚基。推测它们可能参与Xa3/Xa26介导的抗病反应。
Bacterial blight(BB),a vascular disease caused by Xanthomonas oryzae pv Oryza (Xoo),is one of the most serious disease of rice production.Rice is not only a staple in Asia,but also a model for monocots and cereal plant.With increasing resistance gene of BB and publication of Xoo genome sequence,study of BB has been a model of research on plant-microbe interactions.Hence,it is of important theoretical and practical significance to comprehensively and in-depth study of BB and elucidate the genetic and molecular mechanism of resistance.
Xa21 and Xa3/Xa26 are two broad-spectrum resistance genes to Xoo.They both encode receptor like protein kinase and belong to a family.However,they are different in race-specificity.Xa21 is resisitant to PXO99 while Xa3/Xa26 is susceptible.In addition, function of Xa21 was affected by developmental stages of rice.The resistance to PXO99 gradually increased from susceptible 2-leaf stage to complete resistant 9/10-leaf stage with growth of IRBB21.Xa3/Xa26 expressing in Mudanjiang 8 is resistant to PXO61 at whole life.
We constructed chimeric genes encoding diverse part of domain of XA21 and XA3/XA26 and transfer them to the same rice variety Mudanjiang 8.In order to understand the relationship of structure and function of each domain,the resistance, spectrum of resistance and resistance at different stages of chimeric genes and Xa21 as well as Xa3/Xa26 were then investigated.Additionally,we screen proteins interacting with kinase domain of XA3/XA26 by using yeast two hybrid technology.
Chimeric gene D56S.which encodes product containing leucine-rich repeat domain with transmembrane domain of XA3/XA26 and protein kinase domain of XA21,and D57S encodes product containing eucine-rich repeat domain with transmembrane domain of XA21 and protein kinase domain of XA3/XA26.Resistance-spectrum analysis showed that resistance spectrums of D56S or D57S were similar to that of Xa3/Xa26 or Xa21 respectively.However,D52S and D92S,which were different with D57S or D56S only at encoding sequence of cytoplamtic juxtamembrane region,confered no resistance to PXO61.Above results suggested that leucine-rich repeat domain provided the race specificity of XA21 and XA3/XA26 and the important function of juxtamembrane region of XA21 and XA3/XA26.In addition,juxtamembrane region also affect the race specificity of XA21 and XA3/XA26.
Transgenic lines and other rice materials carrying Xa21 or Xa3/Xa26 at 2-leaf stage, 4-leaf stage,maximum-tillering stage and heading stage were inoculated with Xoo strain PXO61,PXO99 and PXO341.Results show that in Mudanjiang 8,D56S,D57S and Xa21 confered resistance to PXO61 at all stages as well as Xa3/Xa26.While in background of IR24 or Minghui 63,Xa21 and Xa3/Xa26 provided resistance to PXO61 only at adult stage.Same results were achieved in experiment when inoculated with PXO99 and PXO341,which indicated that genetic background affected the performance of Xa21 and Xa3/Xa26 at diverse developmental stages.Relative expression level of Xa21 in transgenic Mudanjiang 8 was notable increased compared with in IRBB21.Additionally, at maximum-tillering stage,the expression level of Xa21 reach its top,this was consistent with its resistance.We concluded that gene dosage-effect is an important fact affecting function of Xa21.
Three proteins interact with protein kinase domain of XA3/XA26 were obtained by yeast two hybrid screen.D4 is an mRNA splicing factor,C5 is a autophagy-related protein and C17 is a subunit of G protein.We speculated these proteins involved in Xa3/Xa2 6-mediated resistance.
Xa3/Xa26和Xa21是水稻中两个广谱的抗白叶枯病基因,它们都编码富亮氨酸重复类受体蛋白激酶,也都是属于基因家族成员。然而,它们具有不同的小种特异性,Xa21抗PXO99而Xa3/Xa26感PXO99。此外,Xa21的功能还受到不同生育期的影响。IRBB21对PXU99的抗性会随着植株的发育逐步增强,表现为从2叶期的感病到9-10叶期的完全抗病。而在牡丹江8中表达的Xa3/Xa26对PXO61表现全生育期抗性。
我们构建了包含编码XA21与XA26不同结构域序列的嵌合基因,将它们以及Xa21都转到同样的品种牡丹江8中,在相同背景下考察它们的抗性,抗谱以及在不同生育期时的抗性,解释了该类蛋白各个结构与功能的关系。另外,利用酵母双杂交的方法,筛选与XA3/XA26激酶结构互作的蛋白,寻找参与XA3/XA26介导的抗病反应的蛋白。
D56S编码产物包含XA3/XA26的富亮氨酸重复区和跨膜区以及XA21的激酶结构域;D57S编码产物包含XA21的富亮氨酸重复区和跨膜区以及XA3/XA26的激酶结构域。抗谱分析表明,D56S与D57S的抗谱分别与Xa3/Xa26和Xa21相似。与D56S或D57S只在胞内近膜区编码序列有差异的D52S和D92S则对所有试验菌株都不提供抗性。这些表明富亮氨酸重复区决定了XA21和XA3/XA26对白叶枯菌的小种特异性,而且XA21与XA3/XA26可能具有相同的下游抗病信号传导途径。另外,我们的结果也表明近膜区也能影响该类抗病蛋白的抗性特异性。
在2叶期,4叶期,分蘖盛期,孕穗期以及始穗期对转基因材料和各种携带Xa3/Xa26或者Xa21的材料接种白叶枯菌PXO61,PXO99和PXO341。结果显示,在牡丹江8背景下,D56S,D57S,Xa21与Xa3/Xa26一样,对PXO61具有全生育期抗性。而在IR24背景或者明恢63背景下,Xa21和Xa3/Xa26只表现出成株期抗性。不同材料中Xa21和Xa3/Xa26对PXO99或PXO341的抗性也同样如此。这些都表明Xa21或Xa3/Xa26在不同生育期的抗性差异只是受到遗传背景的影响,而非他们的结构上的差异。实时定量PCR结果显示,在IRBB21中,Xa21的表达量随着植株生长逐渐增强,这与IRBB21从苗期到成株期对白叶枯菌的抗性变化相一致。与IRBB21相比,转Xa21基因牡丹江中Xa21的表达量在不同生育期都显著增强。此外,不论是转基因植株还是IRBB21,Xa21的表达量都在分蘖盛期最高,在此生育期是与Xa21在提供的抗性也最强,说明Xa21的功能具有剂量效应,转基因牡丹江8植株中高水平的Xa21也提供了对白叶枯菌的苗期抗性。
用XA3/XA26的激酶区段筛选到3个在明恢63中与之互作的蛋白。其中,D4是mRNA剪接因子,C5是一个自吞噬相关蛋白,而C17是G蛋白的一个β亚基。推测它们可能参与Xa3/Xa26介导的抗病反应。
Bacterial blight(BB),a vascular disease caused by Xanthomonas oryzae pv Oryza (Xoo),is one of the most serious disease of rice production.Rice is not only a staple in Asia,but also a model for monocots and cereal plant.With increasing resistance gene of BB and publication of Xoo genome sequence,study of BB has been a model of research on plant-microbe interactions.Hence,it is of important theoretical and practical significance to comprehensively and in-depth study of BB and elucidate the genetic and molecular mechanism of resistance.
Xa21 and Xa3/Xa26 are two broad-spectrum resistance genes to Xoo.They both encode receptor like protein kinase and belong to a family.However,they are different in race-specificity.Xa21 is resisitant to PXO99 while Xa3/Xa26 is susceptible.In addition, function of Xa21 was affected by developmental stages of rice.The resistance to PXO99 gradually increased from susceptible 2-leaf stage to complete resistant 9/10-leaf stage with growth of IRBB21.Xa3/Xa26 expressing in Mudanjiang 8 is resistant to PXO61 at whole life.
We constructed chimeric genes encoding diverse part of domain of XA21 and XA3/XA26 and transfer them to the same rice variety Mudanjiang 8.In order to understand the relationship of structure and function of each domain,the resistance, spectrum of resistance and resistance at different stages of chimeric genes and Xa21 as well as Xa3/Xa26 were then investigated.Additionally,we screen proteins interacting with kinase domain of XA3/XA26 by using yeast two hybrid technology.
Chimeric gene D56S.which encodes product containing leucine-rich repeat domain with transmembrane domain of XA3/XA26 and protein kinase domain of XA21,and D57S encodes product containing eucine-rich repeat domain with transmembrane domain of XA21 and protein kinase domain of XA3/XA26.Resistance-spectrum analysis showed that resistance spectrums of D56S or D57S were similar to that of Xa3/Xa26 or Xa21 respectively.However,D52S and D92S,which were different with D57S or D56S only at encoding sequence of cytoplamtic juxtamembrane region,confered no resistance to PXO61.Above results suggested that leucine-rich repeat domain provided the race specificity of XA21 and XA3/XA26 and the important function of juxtamembrane region of XA21 and XA3/XA26.In addition,juxtamembrane region also affect the race specificity of XA21 and XA3/XA26.
Transgenic lines and other rice materials carrying Xa21 or Xa3/Xa26 at 2-leaf stage, 4-leaf stage,maximum-tillering stage and heading stage were inoculated with Xoo strain PXO61,PXO99 and PXO341.Results show that in Mudanjiang 8,D56S,D57S and Xa21 confered resistance to PXO61 at all stages as well as Xa3/Xa26.While in background of IR24 or Minghui 63,Xa21 and Xa3/Xa26 provided resistance to PXO61 only at adult stage.Same results were achieved in experiment when inoculated with PXO99 and PXO341,which indicated that genetic background affected the performance of Xa21 and Xa3/Xa26 at diverse developmental stages.Relative expression level of Xa21 in transgenic Mudanjiang 8 was notable increased compared with in IRBB21.Additionally, at maximum-tillering stage,the expression level of Xa21 reach its top,this was consistent with its resistance.We concluded that gene dosage-effect is an important fact affecting function of Xa21.
Three proteins interact with protein kinase domain of XA3/XA26 were obtained by yeast two hybrid screen.D4 is an mRNA splicing factor,C5 is a autophagy-related protein and C17 is a subunit of G protein.We speculated these proteins involved in Xa3/Xa2 6-mediated resistance.
引文
1.曹应龙.水稻抗白叶枯病基因Xa26和Xa4的遗传和功能分析.[博士学位论文]。武汉:华中农业大学.2007
2.Abedon B G,Tracy W F.Comgrassl of maize(Zea mavs L) delays development of adult plant resistance to common rust(Puccinia sorghi Schw) and European corn borer(Ostrinia nubilalis hubner).1996,J Hered.87:219-223
3.Abramovitch R B,Janjusevic R,Stebbins C E.Martin G B.Type Ⅲ effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity.Proc Natl Acad Sci USA,2006,103:2851-2856
4.Ade J.DeYoung B J.Golstein C.Innes R W.Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease.Proc Natl Acad Sci USA,2007,104:2531-2536
5.Afzal A J,Wood A J,Lightfoot D A.Plant receptor-like serine threonine kinases:roles in signaling and plant defense.Mol Plant Microbe Interact.2008.21:507-517
6.Aifa S,Aydin J,Nordvall G.Lundstrom I.Svensson SPS.Herrnanson O.A basic peptide within the juxtamembrane region is required for EGF receptor dimerization. Exp Cell Res, 2005, 302:108-114
7. Aifa S, Frikha F, Miled N, Johansen K, Lundstrom I, Svensson SPS. Phosphorylation of Thr(654) but not Thr(669) within the juxtamembrane domain of the EGF receptor inhibits calmodulin binding. Biochem Biophys Res Commun, 2006a. 347:381-387
8. Aifa S, Johansen K. Nilsson UK. Liedberg B, Lundstrom I, Svensson SPS. Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance. Cell Signal, 2002, 14:1005-1013
9. Aifa S, Miled N, Frikha F, Aniba M R. Svensson SPS. Rebai A. Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal growth factor receptor provides a model for intracellular dimerization and autophosphorylation. Proteins. 2006b, 62:1036-1043
10. Anderson P A, Lawrence G J. Morrish B C, Ayliffe M A, Finnegan E J, Ellis JG (1997) Inactivation of the Flax Rust Resistance Gene M Associated with Loss of a Repeated Unit within the Leucine-Rich Repeat Coding Region. Plant Cell 9: 641-651
11. Asai T, Tena G, Plotnikova J. Willmann M R. Chiu W L, Gomez-Gomez L, Boiler T. Ausubel F M. Sheen J. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature, 2002. 415:977-983
12. Assmann S M. G protein regulation of disease resistance during infection of rice with rice blast fungus. Sci STKE. 2005. 310:cm13.
13. Axtell M J, Staskawicz B J. Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Cell. 2003 112:369-377
14. Ballvora A. Ercolano M R. Weiss J. Meksem K. Bormann C A. Oberhagemann P. Salamini F, Gebhardt C. The R1 gene for potato resistance to late blight (Phytophthora infest am) belongs to the leucine zipper/NBS/LRR class of plant resistance genes. Plant J. 2002. 30:361-371
15. Becraft P W. Stinard P S. McCarty D R. CRINKLY4: A TNFR-like receptor kinase involved in maize epidermal differentiation. Science. 1996. 273:1406-1409
16.Belkhadir Y,Nimchuk Z,Hubert D A.Mackey D,Dangl J L.Arabidopsis RIN4negatively regulates disease resistance mediated by RPS2 and RPM1 downstream or independent of the NDR1 signal modulator and is not required for the virulence functions of bacterial type Ⅲ effectors AvrRpt2 or AvrRpml.Plant Cell,2004.16:2822-2835
17.Bendahmane A,Kanyuka K,Baulcombe D C.The Rx gene from potato controls separate virus resistance and cell death responses.Plant Cell,1999,11:781-791
18.Bent A F,Kunkel B N,Dahlbeck D,Brown K L,Schmidt R,Giraudat J,Leung J,Staskawicz B J.Rps2 of Arabidopsis Thaliana - a Leucine-Rich Repeat Class of Plant-Disease Resistance Genes.Science,1994,265:1856-1860
19.Bittner-Eddy P D,Crute I R,Holub E B,Beynon J L.RPP13 is a simple locus in Arabidopsis thaliana for alleles that specify downy mildew resistance to different avirulence determinants in Peronospora parasitica.Plant J,2000.21:177-188
20.Bleecker A B,Kende H.Ethylene:A gaseous signal molecule in plants.Annu Rev Cell Dev Biol,2000,16:1-18
21.Botella M A,Parker J E,Frost L N.Bittner-Eddy P D,Beynon J L.Daniels M J.Holub E B,Jones JDG.Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasitica avirulence determinants.Plant Cell.1998,10:1847-1860
22.Boyes D C.Nam J.Dangl J L.The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response.Proc Natl Acad Sci USA,1998,95:15849-15854
23.Brommonschenkel S H,Frary A,Frary A,Tanksley S D.The broad-spectrum tospovirus resistance gene Sw-5 of tomato is a homolog of the root-knot nematode resistance gene Mi.Mol Plant-Microbe Interact.2000,13:1130-1138
24.Brooks D M.Bender C L.Kunkel B N.The Pseudomonas svringae phytotoxin coronatine promotes virulence by overcoming salicylic acid-dependent defences in Arabidopsis thaliana.Mol Plant Pathol.2005,6:629-639
25. Brueggeman R, Rostoks N, Kudrna D, Kilian A, Han F, Chen J, Druka A, Steffenson B. Kleinhofs A. The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinases. Proc Natl Acad Sci USA. 2002. 99:9328-9333
26. Bryan G T, Wu K S, Farrall L, Jia Y L. Hershey H P, McAdams S A. Faulk K N. Donaldson G K, Tarchini R, Valent B. A single amino acid difference distinguishes resistant and susceptible alleles of the rice blast resistance gene Pi-ta. Plant Cell, 2000. 12:2033-2045
27. Burch-Smith T M. Schiff M, Caplan J L, Tsao J, Czymmek K, Dinesh-Kumar S P. A novel role for the TIR domain in association with pathogen-derived elicitors. Plos Biol. 2007. 5:501-514
28. Buschges R, Hollricher K. Panstruga R, Simons G, Wolter M. Frijters A. van Daelen R. van der Lee T. Diergaarde P. Groenendijk J, Topsch S. Vos P. Salamini F. Schulze-Lefert P. The barley Mlo gene: a novel control element of plant pathogen resistance. Cell 1997. 88:695-705
29. Cai D. Kleine M. Kifle S, Harloff H J, Sandal N N. Marcker K A. Klein-Lankhorst R M. Salentijn EMJ. Lange W, Stiekema W J. Wyss U, Grundler FMW. Jung C. Positional Cloning of a Gene for Nematode Resistance in Sugar Beet. Science. 1997. 275:832-834
30. Cameron R K. Zaton K. Intercellular salicylic acid accumulation is important for age-related resistance in Arabidopsis to Pseudomonas syringae. Physiol Mol Plant Pathol, 2004. 65:197-209
31. Cao H. Glazebrook J. Clarke J D, Volko S. Dong X N. The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cell. 1997.88:57-63
32. Cao Y L. Ding X H. Cai M. Zhao J. Lin Y J. Li X H. Xu C G. Wang S P. Expression pattern of a rice disease resistance gene Xa3/Xa26 is differentially regulated by the genetic backgrounds and developmental stages that influence its function. Genetics. 2007, 177:523-533
33. Century K S, Lagman R A. Adkisson M. Morlan J. Tobias R. Schwartz K. Smith A, Love J, Ronald P C. Whalen M C. Developmental control of Xa21-mediated disease resistance in rice. Plant J, 1999, 20:231-236
34. Che F S, Nakajima Y, Tanaka N, Iwano M, Yoshida T, Takayama S. Kadota I. Isogai A. Flagellin from an incompatible strain of Pseudomonas avenae induces a resistance response in cultured rice cells. J Biol Chem, 2000, 275:32347-32356
35. Chen X W, Shang J J, Chen D X, Lei C L, Zou Y, Zhai W X. Liu G Z. Xu J C, Ling Z Z, Cao G, Ma B T, Wang Y P, Zhao X F, Li S G, Zhu L H. A B-lectin receptor kinase gene conferring rice blast resistance. Plant J, 2006, 46:794-804
36. Chen Z Y, Agnew J L, Cohen J D, He P, Shan L B. Sheen J. Kunkel B N. Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology. Proc Natl Acad Sci USA, 2007, 104:20131-20136
37. Chern M, Canlas P E, Fitzgerald H A, Ronald P C. Rice NRR. a negative regulator of disease resistance, interacts with Arabidopsis NPR1 and rice NH1. Plant J, 2005a, 43:623-635
38. Chern M, Fitzgerald H A, Canlas P E, Navarre D A, Ronald P C. Overexpression of a rice NPR1 homolog leads to constitutive activation of defense response and hypersensitivity to light. Mol Plant-Microbe Interact. 2005b. 18:511-520
39. Chern M S, Song W Y. Pi L Y, Yadav R. Hr Z, Zhang Y. Dong X N and Ronald P C. Signaling in rice disease resistance. In: PJGM de Wit. Bisseling T. and Stikema W J. eds.. Biology of plant microbe interactions. vol2. St. Paul. MN. USA. 2000.254-258
40. Chester S. The problem of acquired physiological immunity in plants. Quar Rev Biol. 1933.8:129-154
41. Chinchilla D. Bauer Z. Regenass M. Boiler T. Felix G. The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception. Plam Cell, 2006, 18:465-476
42.Chinchilla D.Zipfel C,Robatzek S,Kemmerling B,Nurnberger T,Jones JDG,Felix G.Boller T.A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence.Nature,2007,448:497-500
43.Chintamanani S.Multani D S,Ruess H.Johal G S.Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred by the maize Hm2 gene.Mol Plant-MicrObe Interact.2008,21:79-86
44.Chu Z H,Yuan M,Yao J L,Ge X J,Yuan B,Xu C G.Li X H,Fu B y,Li Z K,Bennetzen J L,Zhang Q F,Wang S P.Promoter mutations of an essential gene for pollen development result in disease resistance in rice.Gene Dev,2006,20:1250-1255
45.Clark S E,Williams R W.Meyerowitz E M.The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis.Cell,1997.89:575-585
46.Coaker G,Falick A,Staskawicz B.Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin.Science,2005,308:548-550
47.Collins N,Drake J,Ayliffe M,Sun Q,Ellis J.Hulbert S,Pryor T.Molecular characterization of the maize Rp1-D rust resistance haplotype and its mutants.Plant Cell,1999,11:1365-1376
48.Cooley M B,Pathirana S,Wu H J.Kachroo P.Klessig D F.Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and oomycete pathogens.Plant Cell,2000,12:663-676
49.Cooper B.Clarke J D.Budworth P,Kreps J.Hutchison D.Park S,Guimil S.Dunn M.Luginbuhl P.Ellero C.Goff S A.Glazebrook J.A network of rice genes associated with stress response and seed development.Proc Natl Acad Sci USA.2003.100:4945-4950
50.Cote F.Roberts K A.Hahn M G.Identification of high-affinity binding sites for the hepta-beta-glucoside elicitor in membranes of the model legumes Medicago truncatula and Lotus japonicus.Planta.2000.211:596-605
51.Craddock B P.Cotter C.Miller W T.Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region.Febs Lett,2007.581:3235-3240
52.de Majnik J,Ogbonnaya F C,Moullet O,Eagudah E S.The Crel and Cre3 nematode resistance genes are located at homeologous loci in the wheat genome.Mol Plant-Microbe Interact,2003,16:1129-1134
53.de Torres-Zabala M,Truman W,Bennett M H,Lafforgue G,Mansfield J W,Egea P R.Bogre L,Grant M.Pseudomonas syringae pv.tomato hijacks the Arabidopsis abscisic acid signalling pathway to cause disease.Embo J.2007.26:1434-1443
54.Deslandes L,Olivier J,Peeters N,Feng D X,Khounlotham M,Boucher C,Somssich L,Genin S,Marco Y.Physical interaction between RRS1-R,a protein conferring.resistance to bacterial wilt,and PopP2,a type Ⅲ effector targeted to the plant nucleus.Proc Natl Acad Sci USA,2003,100:8024-8029
55.Deslandes L,Olivier J,Theulieres F.Hirsch J,Feng D X,Bittner-Eddy R Beynon J,Marco Y.Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene,a member of a novel family of resistance genes.Proc Natl Acad Sci USA,2002,99:2404-2409
56.Despres C,Chubak C,Rochon A,Clark R,Bethune T,Desveaux D,Fobert P R.The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1.Plant Cell,2003,15:2181-2191
57.Deverall B J.In:Brian P W,Pringle JWS.Defense Mechanisms of Plants.vol 19.Cambridge University Press.1977
58.Diener A C,Ausubel F M.Resistance to fusarium oxysporum 1,a dominant Arabidopsis disease-resistance gene.is not race specific.Genetics.2005,171:305-321
59.Ding X H.Cao Y L,Huang L L.Zhao J.Xu C G.Li X H,Wang S R Activation of the indole-3-acetic acid-amido synthetase GH3-8 suppresses expansin expression and promotes salicylate- and jasmonate-independent basal immunity in rice.Plant Cell.2008.20:228-240
60.Dixon M S.Hatzixanthis K.Jones D A.Harrison K.Jones J D.The tomato Cf-5 disease resistance gene and six homologs show pronounced allelic variation in leucine-rich repeat copy number. Plant Cell 1998, 10:1915-1925
61. Dixon M S, Jones D A, Keddie J S. Thomas C M, Harrison K, Jones J D. The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. Cell, 1996, 84:451-459
62. Dodds P N, Lawrence G J, Catanzariti A M, Teh T, Wang CIA, Ayliffe M A. Kobe B, Ellis J G. Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes. Proc Natl AcadSci USA, 2006, 103:8888-8893
63. Dodds P N, Lawrence G J, Ellis J G. Six Amino Acid Changes Confined to the Leucine-Rich Repeat P-Strand/p-Turn Motif Determine the Difference between the P and P2 Rust Resistance Specificities in Flax. Plant cell, 2001, 13:163-178
64. Dong X N. NPR1, all things considered. Curr Opin Plant Biol, 2004, 7:547-552
65. Eckardt N A. Mechanism of Pto-mediated disease resistance: Structural analysis provides a new model. Plant Cell, 2004, 16:2543-2545
66. Eitas T K, Nimchukt Z L. Dangl J L. Arabidopsis TA01 is a TIR-NB-LRR protein that contributes to disease resistance induced by the Pseudomonas syringae effector AvrB. Proc Natl Acad Sci USA. 2008, 105:6475-6480
67. Ellis J G, Lawrence G J. Luck J E, Dodds P N. Identification of regions in alleles of the flax rust resistance gene L that determine differences in gene-for-gene specificity. Plant Cell 1999. 11:495-506
68. Ernst K. Kumar A. Kriseleit D. Kloos D U. Phillips M S. Ganal M W. The broad-spectrum potato cyst nematode resistance gene (Hero) from tomato is the only member of a large gene family of NBS-LRR genes with an unusual amino acid repeat in the LRR region. Plant J. 2002. 31:127-136
69. Faigon-Soverna A. Harmon F G Storani L. Karayekov E. Staneloni R J. Gassmann W. Mas P. Casal J J. Kay S A. Yanovsky M J. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell 2006, 18:2919-2928
70. Falk A, Feys B J. Frost L N. Jones JDG. Daniels M J. Parker J E. EDS1. an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc Natl Acad Sci USA, 1999. 96:3292-3297
71. Felix G. Boiler T. Molecular sensing of bacteria in plants - The highly conserved RNA-binding motif RNP-1 of bacterial cold shock proteins is recognized as an elicitor signal in tobacco. J Biol Chem, 2003, 278:6201-6208
72. Felix G, Duran J D, Volko S, Boiler T. Plants have a sensitive perception system for the most conserved domain of bacterial flagellin. Plant J, 1999a. 18:265-276
73. Feuillet C, Travella S, Stein N, Albar L, Nublat A. Keller B. Map-based isolation of the leaf rust disease resistance gene Lr10 from the hexaploid wheat (Triricum aestivum L.) genome. Proc Natl Acad Sci USA, 2003, 100:15253-15258
74. Feys B J, Moisan L J. Newman M A, Parker J E. Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4. Embo J. 2001. 20:5400-5411
75. Fliegmann J, Mithofer A. Wanner G, Ebel J. An ancient enzyme domain hidden in the putative beta-glucan elicitor receptor of soybean may piay an active part in the perception of pathogen-associated molecular patterns during broad host resistance. .J Biol Chem, 2004. 279:1132-1140
76. Fliegmann J. Montel E. Djulic A. Cottaz S, Driguez H. Ebel M G. Catalytic properties of the bifunctional soybean beta-glucan-binding protein. a member of family 81 glycoside hydrolases. Febs Lett. 2005, 579:6647-6652
77. Fodor J, Gullner G. Adam A L. Barna B, Komives T. Kiraly Z. Local and Systemic Responses of Antioxidants to Tobacco Mosaic Virus Infection and to Salicylic Acid in Tobacco (Role in Systemic Acquired Resistance). Plant Physiol. 1997. 114:1443-1451
78. Forouhar F. Yang Y. Kumar D. Chen Y. Fridman E. Park S W. Chiang Y. Acton T B. Montelione G T. Pichersky E. Klessig D F. Tong L. Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity.Proc Natl Acad Sci USA,2005,102:1773-1778
79.Fu Z Q,Guo M,Jeong B R,Tian F,Elthon T E,Cerny R L.Staiger D,Alfano J R.A type Ⅲ effector ADP-ribosylates RNA-binding proteins and quells plant immunity.Nature,2007,447:284-288
80.Gabriel D W.Rolfe B G.Working Models of Specific Recognition in Plant-Microbe Interactions.Annu Rev Phytopathol,1990,28:365-391
81.Gaffney T,Friedrich L,Vemooij B,Negrotto D,Nye G,Uknes S,Ward E,Kessmann H,Ryals J.Requirement of salicylic acid for the induction of systemic acquired resistance.Science,1993,261:754-756
82.Galiana E,Riviere M P,Pagnotta S,Baudouin E,Panabieres F,Gounon P,Boudier L.Plant-induced cell death in the oomycete pathogen Phytophthora parasitica.Cellular Microbiol,2005,7:1365-1378
83.Gassmann W.Hinsch M E,Staskawicz B J.The Arabidopsis RPS4bacterial-resistance gene is a member of the TIR-NBS-LRR family of disease-resistance genes.Plant J,1999,20:265-277
84.Geldner N,Hyman D L,Wang X L,Schumacher K.Chory J.Endosomal signaling of plant steroid receptor kinase BRI1.Gene Dev,2007.21:1598-1602
85.Geldner N,Jurgens G.Endocytosis in signalling and development.Curr Opin Plant Biol.2006,9:589-594
86.Godiard L.Sauviac L,Torii KU,Grenon O.Mangin B,Grimsley N H,Marco Y.ERECTA.an LRR receptor-like kinase protein controlling development pleiotropically affects resistance to bacterial wilt.Plant J.2003.36:353-365
87.Goggin F L,Shah G,Williamson V M,Ullman D E.Developmental regulation of Mi-mediated aphid resistance is independent of Mi-1.2 transcript levels.Mol Plant-Microbe Interact.2004,17:532-536
88.Gomez-Gomez L,Boiler T.FLS2:An LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis.Mol Cell,2000.5:1003-1011
89.Gomez-Gomez L,Boller T.Flagellin perception:a paradigm for innate immunity.Trends Plant Sci,2002,7:251-256
90.Gouger A,Senchou V,Govers F,Sanson A.Barre A,Rouge P.Pont-Lezica R,Canut H.Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.Plant Physiol,2006,140:81-90
91.Grant M R,Godiard L,Straube E,Ashfield T.Lewald J.Sattler A,Innes R W,Dangl J L.Structure of the Arabidopsis Rpm1 gene enabling dual-specificity disease resistance.Science,1995,269:843-846
92.Gu K Y,Sangha J S,Li Y,Yin Z C.High-resolution genetic mapping of bacterial blight resistance gene Xa10.Theor Appl Genet.2008,116:155-163
93.Gu K Y,Yang B,Tian D S,Wu L F.Wang D J,Sreekala C,Yang F.Chu Z Q,Wang G L,White F F,Yin Z C.R gene expression induced by a type-Ⅲ effector triggers disease resistance in rice.Nature,2005,435:1122-1125
94.Guttman D S,Vinatzer B A,Sarkar S F.Ranall M V.Kettler G.Greenberg J T.A functional screen for the type Ⅲ(Hrp) secretome of the plant pathogen Pseudomonas syringae.Science,2002,295:1722-1726
95.Halterman D,Zhou F S,Wei F S,Wise R P.Schulze-Lefert P.The MICA6 coiled-coil,NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria graminis f.sp hordei in barley and wheat.Plant J,2001,25:335-348
96.Halterman D A,Wise R P.A single-amino acid substitution in the sixth leucine-rich repeat of barley MLA6 and MLA13 alleviates dependence on RAR1 for disease resistance signaling.Plant J,2004.38:215-226
97.Hann D R.Rathjen J P.Early events in the pathogenicity of Pseudomonas syringae on Nicotiana benthamiana.Plant J,49:607-618
98.Haubrick L L,Assmann S M.Brassinosteroids and plant function:some clues,more puzzles.Plant Cell Environ.2006.29:446-457
99.Hauck P.Thilmony R.He S Y.A Pseudomonas syringae type Ⅲ effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants.Proc Natl Acad Sci USA, 2003, 100:8577-8582
100. He J X, Gendron J M, Sun Y, Gampala SSL, Gendron N, Sun C Q. Wang Z Y. BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science, 2005, 307:1634-1638
101. He K, Gou X P, Yuan T, Lin H H, Asami T. Yoshida S. Russell S D. Li J. BAK1 and BKK1 regulate Brassinosteroid-dependent growth and Brassinosteroidlndependent cell-death pathways. Curr Biol, 2007, 17:1109-1115
102. He P, Shan L, Lin N C, Martin G B, Kemmerling B, Nurnberger T, Sheen J. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell, 2006, 125:563-575
103. He Z H, He D Z, Kohorn B D. Requirement for the induced expression of a cell wall associated receptor kinase for survival during the pathogen response. Plant J. 1998, 14:55-63
104. He Z H, Wang Z Y. Li J M, Zhu Q. Lamb C, Ronald P C, Chory J. Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science. 2000, 288:2360-2363
105. Hepworth S R, Zhang Y L. McKim S, Li X, Haughn G. BLADE-ON-PET1OLE -dependent signaling controls leaf and floral patterning in Arabidopsis. Plant Cell. 2005, 17:1434-1448
106. Herve C, Dabos P. Galaud JP. Rouge P. Lescure B. Characterization of an Arabidopsis thaliana gene that defines a new class of putative plant receptor kinases with an extracellular lectin-like domain. J Mol Biol. 1996, 258:778-788
107. Horton R M, Hunt H D. Ho S N. Pullen J K. Pease L R. Engineering hybrid genes without the use of restriction enzymes, gene-splicing by overlap extension. Gene. 1989,77:61-68
108. Inoue T, Higuchi M. Hashimoto Y. Seki M. Kobayashi M. Kato T, Tabata S. Shinozaki K. Kakimoto T. Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature. 2001, 409:1060-1063
109. Iyer A S, McCouch S R. The rice bacterial blight resistance gene xa5 encodes a novel form of disease resistance. Mol Plant-Microbe Interact, 2004, 17:1348-1354
110. Jablonska B. Ammiraju JSS. Bhattarai K K. Mantelin S. de Ilarduya O M, Roberts P A. Kaloshian I. The Mi-9 gene from Solanum arcanum conferring heat-stable resistance to root-knot nematodes is a homolog of Mi-1. Plant Physiol, 2007. 143:1044-1054
111. Janjusevic R, Abramovitch R B. Martin G B, Stebbins C E. A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase. Science, 2006. 311:222-226
112. Jelenska J, Yao N, Vinatzer B A, Wright C M, Brodsky J L, Greenberg J T. A J domain virulence effector of Pseudomonas syringae remodels host chloroplasts and suppresses defenses. Curr Biol, 2007. 17:499-508
113. Jeong S, Trotochaud A E. Clark S E. The Arabidopsis CLAVATA2 gene encodes a receptor-like protein required for the stability of the CLAVATA1 receptor-like kinase. Plant Cell, 1999. 11:1925-1933
114. Jia Y, McAdams S A. Bryan G T, Hershey H P, Valent B. Direct interaction of resistance gene and avirulence gene products confers rice blast resistance. Embo J. 2000, 19:4004-4014
115. Jirage D. Tootle T L. Reuber T L, Frost L N. Feys B J, Parker J E. Ausubel F M. Glazebrook J. Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling. Proc Natl Acad Sci USA. 1999. 96:13583-13588
116. Jones D A, Thomas C M. Hammond-Kosack K E. Balint-Kurti P J. Jones J D. Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science. 1994. 266:789-793
117. Kachroo P. Shanklin J. Shah J. Whittle E J. Klessig D F. A fatty acid desaturase modulates the activation of defense signaling pathways in plants. Proc Natl Acad Sci USA, 2001. 98:9448-9453
118. Kaku H, Nishizawa Y. Ishii-Minami N. Akimoto-Tomiyama C. Dohmae N. Takio K. Minami E. Shibuva N. Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor.Proc Natl Acad Sci USA.2006,103:11086-11091
119.Kawchuk L M,Hachey J,Lynch D R,Kulcsar F,van Rooijen G.Waterer D R.Robertson A,Kokko E,Byers R,Howard R J,Fischer R,Prufer D.Tomato Ve disease resistance genes encode cell surface-like receptors.Proc Natl Acad Sci USA,2001.98:6511-6515
120.Kim H S,Desveaux D,Singer A U,Patel P,Sondek J,Dangl J L.The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target,RIN4,from Arabidopsis membranes to block RPM1 activation.Proc Natl Acad Sci USA,2005,102:6496-6501
121.Kinoshita T,Cano-Delgado A C,Seto H,Hiranuma S,Fujioka S,Yoshida S.Chory J.Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1.Nature,2005,433:167-171
122.Kumar D,Gustafsson C,Klessig D F.Validation of RNAi silencing specificity using synthetic genes:salicylic acid-binding protein 2 is required for innate immunity in plants.Plant J,2006.45:863-868
123.Kunze G,Zipfel C,Robatzek S,Niehaus K,Boller T,Felix G.The N terminus of bacterial elongation factor Tu elicits innate immunity in Arabidopsis plants.Plant Cell 2004,16:3496-3507
124.Kus J V,Zaton K,Sarkar R.Cameron R K.Age-related resistance in Arabidopsis is a developmentally regulated defense response to Pseudomonas syringae.Plant Cell.2002.14:479-490
125.Lagudah E S.Moullet O,Appels R.Map-based cloning of a gene sequence encoding a nucleotide-binding domain and a leucine-rich region at the Cre3 nematode resistance locus of wheat.Genome.1997,40:659-665
126.Lawrence G J.Finnegan E J.Ayliffe M A,Ellis J G.The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N.Plant Cell.1995,7:1195-1206
127.Leisner S M,Turgeon R,Howell S H.Effects of host plant development and genetic-determinants on the long-distance movement of cauliflower mosaic-virus in Arabidopsis.Plant Cell,1993,5:191-202
128.Lenhard M,Laux T.Stem cell homeostasis in the Arabidopsis shoot meristem is regulated by intercellular movement of CLAVATA3 and its sequestration by CLAVATA1.Development,2003,130:3163-3173
129.Li J M,Chory J.A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction.Cell,1997,90:929-938
130.Li J M,Nam K H.Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase.Science,2002.295:1299-1301
131.Li J M,Nam K H,Vafeados D,Chory J.BIN2,a new brassinosteroid-insensitive locus in Arabidopsis.Plant Physiol,2001.127:14-22
132.Li S Q,Covino N D.Stein E G.Till J H.Hubbard S R.Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.J Biol Chem,2003,278:26007-26014
133.Li X Y.Lin H Q,Zhang W G,Zou Y,Zhang J,Tang X Y.Zhou J M.Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors.Proc Natl Acad Sci USA,2005,102:12990-12995
134.Lin F.Chen S.Que Z Q,Wang L,Liu X Q,Pan Q H.The blast resistance gene Pi37encodes a nucleotide binding site-leucine-rich repeat protein and is a member of a resistance gene cluster on rice chromosome 1.Genetics.2007.177:1871-1880
135.Lindgren P B.The role of hrp genes during plant-bacterial interactions.Annu Rev Phytopathol,1997.35:129-152
136.Liu G Z,Pit L Y,Walker J C,Ronald P C.Song W Y.Biochemical characterization of the kinase domain of the rice disease resistance receptor-like kinase XA21.J Biol Chem.2002.277:20264-20269
137.Liu K D.Wang J.Li H B,Xu C G.Liu A M,Li X H.Zhang Q.A genome-wide analysis of wide compatibility in rice and the precise location of the S5 locus in the molecular map. Theor Appl Genet, 1997, 95:809-814
138. Liu X Q, Lin F, Wang L. Pan Q H. The in silico map-based cloning of Pi36. a rice coiled-coil-nucleotide-binding site-leucine-rich repeat gene that confers race-specific resistance to the blast fungus. Genetics. 2007, 176:2541-2549
139. Liu Y, Schiff M, Czymmek K. Talloczy Z, Levine B, Dinesh-Kumar S P. Autophagy regulates programmed cell death during the plant innate immune response. Cell. 2005. 121:567-577
140. Llorente F, Alonso-Blanco C, Sanchez-Rodriguez C, Jorda L, Molina A. ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resistance to the necrotrophic fungus Plectosphaerella cucumerina. Plant J, 2005, 43:165-180
141. Lotan T, Ori N, Fluhr R. Pathogenesis-related proteins are developmentally regulated in Tobacco flowers. Plant Cell. 19891:881-887
142. Mackey D, Holt B F, Wiig A, Dangl J L. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell, 2002, 108:743-754
143. Maldonado A M, Doerner P, Dixon R A. Lamb C J, Cameron R K. A putative lipid transfer protein involved in systemic resistance signalling in Arabidopsis. Nature. 2002,419:399-403
144. Marois E, Van den Ackerveken G, Bonas U. The Xanthomonas type III effector protein AvrBs3 modulates plant gene expression and induces cell hypertrophy in the susceptible host. Mol Plant-Microbe Interact. 2002, 15:637-646
145. Martin G B. Brommonschenkel S H. Chunwongse J, Frary A. Ganal M W, Spivey R. Wu T, Earle E D, Tanksley S D. Map-based cloning of a protein kinase gene conferring disease resistance in tomato. Science. 1993, 262:1432-1436
146. Martin G B, Frary A, Wu T. Brommonschenkel S. Chunwongse J, Earle E D. Tanksley S D. Member of the Tomato Pto Gene Family Confers Sensitivity to Fenthion Resulting in Rapid Cell Death. Plant Cell, 1994, 6:1543-1552
147. Martinez C, Pons E, Prats G. Leon J. Salicylic acid regulates flowering time and links defence responses and reproductive development. Plant J, 2004, 37:209-217
148. McCarty D R, Chory J. Conservation and innovation in plant signaling pathways. Cell. 2000, 103:201-209
149. McDowell J M, Dhandaydham M. Long T A, Aarts MGM. Goff S, Holub E B. Dangl J L. Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis. Plant Cell, 1998. 10:1861-1874
150. McDowell J M, Williams S G, Funderburg N T. Eulgem T, Dangl J L. Genetic analysis of developmentally regulated resistance to downy mildew (Hyaloperonospora parasitica) in Arabidopsis thaliana. Mol Plant-Microbe Interact, 2005, 18:1226-1234
151. Melotto M, Underwood W, Koczan J, Nomura K, He S Y. Plant stomata function in innate immunity against bacterial invasion. Cell, 2006, 126:969-980
152. Meszaros T, Heifer A. Hatzimasoura E, Magyar Z. Serazetdinova L, Rios G, Bardoczy V, Teige M, Koncz C, Peck S, Bogre L. The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin. Plant J, 2006. 48:485-498
153. Mew T W, Vera Cruz C M and Reyes R C. Characterization of Resistance in Rice to Bacterial Blight. 1980, IRRI, Los Banos. Lagura Philippines
154. Meyers B C, Chin D B. Shen K A. Sivaramakrishnan S. Lavelle D O, Zhang Z. Michelmore R W. The major resistance gene cluster in lettuce is highly duplicated and spans several megabases. Plant Cell 1998, 10:1817-1832
155. Milligan S B, Bodeau J. Yaghoobi J. Kaloshian I. Zabel P. Williamson V M. The root knot nematode resistance gene Mi from tomato is a member of the leucine zipper. nucleotide binding, leucine-rich repeat family of plant genes. Plant Cell, 1998. 10:1307-1319
156. Miya A. Albert P. Shinya T. Desaki Y. Ichimura K. Shirasu K. Narusaka Y. Kawakami N. Kaku H. Shibuya N. CERK1. a LysM receptor kinase. is essential for chitin elicitor signaling in Arabidopsis. Proc Natl Acad Sci USA. 2007. 104:19613-19618
157. Moose S P. Sisco P H. Glossy 15 Controls the Epidermal Juvenile-to-Adult Phase-Transition in Maize. Plant Cell, 1994, 6:1343-1355
158. Morillo S A, Tax F E. Functional analysis of receptor-like kinases in monocots and dicots. Curr Opin Plant Biol 2006, 9:460-469
159. Mou Z, Fan W H. Dong X N. Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes. Cell, 2003. 113:935-944
160. Muller R, Bleckmann A. Simon R. The receptor kinase CORYNE of Arabidopsis transmits the stem cell-limiting signal CLAVATA3 independently of CLAVATA1. Plant Cell, 2008, 20:934-946
161. Nam K H, Li J M. BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell, 2002. 110:203-212
162. Nandi A, Krothapaili K, Buseman C M, Li M Y, Welti R, Enyedi A. Shah J. Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Plant Cell, 2003, 15:2383-2398
163. Nandi A, Welti R, Shah J. The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. Plant Cell. 2004, 16:465-477
164. Ni C Y. Murphy M P, Golde T E, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science. 2001. 294:2179-2181
165. Nielsen M E, Lok F. Nielsen H B. Distinct developmental defense activations in barley embryos identified by transcriptome profiling. Plant Mol Biol. 2006. 61:589-601
166. Nomura K, DebRoy S. Lee Y H. Pumplin N. Jones J. He S Y A bacterial virulence protein suppresses host innate immunity to cause plant disease. Science. 2006.313:220-223
167. Ori N. Eshed Y, Paran I. Presting G Aviv D. Tanksley S D. Zamir D. Fluhr R. The 12C family from the wilt disease resistance locus I2 belongs to the nucleotide binding.leucine-rich repeat superfamily of plant resistance genes.Plant Cell,1997.9:521-532
168.Panter S N,Hammond-Kosack K E,Harrison K,Jones JDG,Jones D A.Developmental control of promoter activity is not responsible for mature onset of Cf-9B-mediated resistance to leaf mold in tomato.Mol Plant-Microbe Interact.2002,15:1099-1107
169.Park S W,Kaimoyo E,Kumar D,Mosher S,Klessig D F.Methyl salicylate is a critical mobile signal for plant systemic acquired resistance.Science,2007.318:113-116
170.Parker J E,Coleman M J,Szabo V,Frost L N,Schmidt R,vanderBiezen E A.Moores T,Dean C,Daniels M J,Jones JDG.The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 receptors with N and L6.Plant Cell,1997,9:879-894
171.Pastuglia M,Roby D.Dumas C,Cock J M.Rapid induction by wounding and bacterial infection of an S Gene family receptor-like kinase gene in Brassica oleracea.Plant Cell,1997,9:49-60
172.Peng Y,Bartley L,E.Chen X,Dardick C,Chern M,Ruan R,Canlas P E,Ronald P C.OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas oryzae pv.oryzae in Rice.Mol Plant,2008,1:446-458
173.Peng Y,Park J C,Dardick C.Ruan R and Ronald P C.Xb15 is a negative regulator of Xa21-mediated disease resistance.Abstract,The 5th International rice Genetics Symposium.2005.Manila.Philippines
174.Petnicki-Ocwieja T.Schneider D J.Tam V C,Chancey S T.Shah I,.Jamir Y.Schechter L,M,Janes M D,Buell C R.Fang X,Collmer A,Alfano J R.Genomewide identification of proteins secreted by the Hrp type Ⅲ protein secretion system of Pseudomonas syringae pv.tomato DC3000.Proc Natl Acad Sci USA,2002.99:7652-7657
175.Pieterse CMJ.van Wees SCM.van Pelt J A.Knoester M.Laan R.Gerrits N.Weisbeek P J, van Loon L C. A novel signaling pathway controlling induced systemic resistance in Arabidopsis. Plant Cell, 1998. 10:1571-1580
176. Preston G M, Studholme D J, Caldelari I. Profiling the secretomes of plant pathogenic Proteobacteria. Ferns Microbiol Rev, 2005. 29:331-360
177. Qu S H, Liu G F. Zhou B. Bellizzi M, Zeng L R, Dai L Y. Han B. Wang G L. The broad-spectrum blast resistance gene Pi9 encodes a nucleotide-binding site-leucine-rich repeat protein and is a member of a multigene family in rice. Genetics, 2006, 172:1901 -1914
178. Radwan O, Mouzeyar S, Nicolas P, Bouzidi M F. Induction of a sunflower CC-NBS-LRR resistance gene analogue during incompatible interaction with Plasmopara halstedii. J Exp Bot, 2005, 56:567-575
179. Robatzek S, Chinchilla D, Boiler T. Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. Gene Dev, 2006. 20:537-542
180. Roine E, Wei W S, Yuan J, NurmiahoLassila E L, Kalkkinen N, Romantschuk M, He S Y. Hrp pilus: an hrp-dependent bacterial surface appendage produced by Pseudomonas syringae pv tomato DC3000. Proc Natl Acad Sci USA, 1997, 94:3459-3464
181. Rojo E, Sharma V K, Kovaleva V, Raikhel N V. Fletcher J C. CLV3 is localized to the extracellular space, where it activates the Arabidopsis CLAVATA stem cell signaling pathway. Plant Cell, 2002, 14:969-977
182. Ron M. Avni A. The receptor for the fungal elicitor ethylene-inducing xylanase is a member of a resistance-like gene family in tomato. Plant Cell. 2004. 16:1604-1615
183. Rooney HCE, van 't Klooster J W. van der Hoorn RAL. Joosten M. Jones JDG. de Wit P. Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science. 2005, 308:1783-1786
184. Russinovaa E, Borst J W. Kwaaitaal M, Cano-Delgado A. Yin Y H. Chory j. de Vries S C. Heterodimerization and endocytosis of Arabidopsis brassinosteroid receptors BR11 and AtSERK3 (BAK1). Plant Cell 2004. 16:3216-3229
185. Rusterucci C. Zhao Z, Haines K, Mellersh D, Neumann A. Cameron R K. Age-related resistance to Pseudomonas syringae pv. tomato is associated with the transition to flowering in Arabidopsis and is effective against Peronospora parasitica. Physiol Mol Plant Pathol. 2005, 66:222-231
186. Salmeron J M, Oldroyd GED, Rommens CMT, Scofield S R. Kim H S. Lavelle D T. Dahlbeck D, Staskawicz B J. Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. Cell, 1996,86:123-133
187. Salzberg S L, Sommer D D, Schatz M C, Phillippy A M. Rabinowicz P D, Tsuge S. Furutani A, Ochiai H, Delcher A L, Kelley D, Madupu R. Puiu D, Radune D. Shumway M, Trapnell C, Aparna G, Jha G, Pandey A. Patil P B. Ishihara H et al. Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A. BMC Genom, 2008 , 9:204
188. Salzman R A. Tikhonova I, Bordelon B P. Hasegawa P M. Bressan R A. Coordinate accumulation of antifungal proteins and hexoses constitutes a developmentally controlled defense response during fruit ripening in grape. Plant Physiol, 1998. 117:465-472
189. Schoof H, Lenhard M. Haecker A, Mayer KFX. Jurgens G. Laux T. The stem cell population of Arabidopsis shoot meristems is maintained by a regulatory loop between the CLAVATA and WUSCHEL genes. Cell. 2000. 100:635-644
190. Schornack S. Ballvora A. Gurlebeck D, Peart J. Baulcombe D. Ganal M. Baker B. Bonas U. Lahaye T. The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severly truncated derivatives of AvrBs4 and overexpressed AvrBs3. Plant J. 2004. 37:46-60
191. Shang Y L. Li X Y. Cui H T, He P. Thilmony R. Chintamanani S. Zwiesier-Vollick J. Gopalan S. Tang X Y. Zhou J M. RAR1. a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc \'atl Acad Sci USA. 2006. 103:19200-19205
192. Shen Q H, Saijo Y, Mauch S, Biskup C. Bieri S. Keller B, Seki H. Ulker B, Somssich IE, Schulze-Lefert P. Nuclear activity of MLA immune receptors links isolate-specific and basal disease-resistance responses. Science. 2007, 315:1098-1103
193. Shen Q H, Zhou F S, Bieri S, Haizel T. Shirasu K, Schulze-Lefert P. Recognition specificity and RAR1/SGT1 dependence in barley Mla disease resistance genes to the powdery mildew fungus. Plant Cell. 2003. 15:732-744
194. Shigeoka S, Ishikawa T, Tamoi M, Miyagawa Y, Takeda T, Yabuta Y, Yoshimura K. Regulation and function of ascorbate peroxidase isoenzymes. J Exp Bot, 2002, 53:1305-1319
195. Shirano Y, Kachroo P, Shah J, Klessig D F. A gain-of-function mutation in an Arabidopsis Toll Interleukin-1 Receptor-Nucleotide Binding Site-Leucine-Rich Repeat type R gene triggers defense responses and results in enhanced disease resistance. Plant Cell. 2002, 14:3149-3162
196. Shiu S H, Karlowski W M, Pan R S, Tzeng Y H. Mayer KFX, Li W H. Comparative analysis of the receptor-like kinase family in Arabidopsis and rice. Plant Cell. 2004. 16:1220-1234
197. Sohn K H, Lei R, Nemri A. Jones JDG. The downy mildew effector proteins ATR1 and ATR13 promote disease susceptibility in Arabidopsis thaliana. Plant Cell. 2007. 19:4077-4090
198. Song W Y, Pi L Y, Bureau T E, Ronald P C. Identification and characterization of 14 transposon-like elements in the noncoding regions of members of the Xa21 family of disease resistance genes in rice. Mol Gen Genet. 1998, 258:449-456
199. Song W Y. Pi L Y, Wang G L, Gardner J. Holsten T. Ronald P C. Evolution of the rice Xa21 disease resistance gene family. Plant Cell 1997 9:1279-1287
200. Song W Y, Wang G L. Chen L L, Kim H S. Pi L Y. Holsten T, Gardner J, Wang B. Zhai W X. Zhu L H. Fauquet C. Ronald P C. A receptor kinase-like protein encoded by the rice disease resistance gene. Xa21. Science. 1995. 270:1804-1806
201. Staal J, Kaliff M. Dewaele E. Persson M. Dixelius C. RLM3. a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens.Plant J.2008,55:188-200
202.Suarez-Rodriguez M C,Adams-Phillips L.Liu Y D.Wang H C,Su S H.Jester P J,Zhang S Q,Bent A F,Krysan P J.MEKK1 is required for flg22-induced MPK4activation in Arabidopsis plants.Plant Physiol,2007,143:661-669
203.Sugio A,Yang B,Zhu T,White F F.Two type Ⅲ effector genes of Xanthomonas oryzae pv.oryzae control the induction of the host genes OsTFIIA gamma 1 and OsTFX1 during bacterial blight of rice.Proc Natl Acad Sci USA,2007.104:10720-10725
204.Suharsono U,Fujisawa Y,Kawasaki T,Iwasaki Y,Satoh H,Shimamoto K.The heterotrimeric G protein α subunit acts upstream of the small GTPase Rac in disease resistance of rice.Proc Natl Acad Sci USA.2002,99:13307-13312
205.Sun X L,Cao Y L,Wang S R Point mutations with positive selection were a major force during the evolution of a receptor-kinase resistance gene family of rice.Plant Physiol,2006,140:998-1008
206.Sun X L,Cao Y L,Yang Z F,Xu C G.Li X H,Wang S R Zhang Q F.Xa26,a gene conferring resistance to Xanthomonas orvzae pv.oryzae in rice,encodes an LRR receptor kinase-like protein.Plant J.2004,37:517-527
207.Swiderski M R,Innes R W.The Arabidopsis PBS1 resistance gene encodes a member of a novel protein kinase subfamily.Plant J.2001,26:101 -112
208.Tai T H,Dahlbeck D.Clark E T.Gajiwala R Pasion R,Whalen M C.Stall R E.Staskawicz B J.Expression of the Bs2 pepper gene confers resistance to bacterial spot disease in tomato.Proc Natl Acad Sci USA.1999.96:14153-14158
209.Tameling W I,Vossen J H,Albrecht M.Lengauer T,Berden J A.Haring M A.Comelissen B J.Takken F L.Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation.Plant Physiol,2006,140:1233-1245
210.Takahashi H.Miller J.Nozaki Y.Sukamto,Takeda M.Shah J.Hase S,Ikegami M.Ehara Y.Dinesh-Kumar S P.RCY1.an Arahidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism. Plant J, 2002. 32:655-667
211. Takasaki T. Hatakeyama K, Suzuki G, Watanabe M, Isogai A. Hinata K. The S receptor kinase determines self-incompatibility in Brassica stigma. Nature, 2000. 403:913-916
212. Tang X, Frederick R D. Zhou J, Halterman D A, Jia Y, Martin G B. Initiation of plant disease resistance by physical interaction of AvrPto and Pto Kinase. Science. 1996, 274:2060-2063
213. Thomas C M, Jones D A, Parniske M, Harrison K, Balint-Kurti P J, Hatzixanthis K, Jones J D. Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequences that determine recognitional specificity in Cf-4 and Cf-9. Plant Cell 1997, 9:2209-2224
214. Thurow C. Schiermeyer A. Krawczyk S, Butterbrodt T, Nickolov K. Gatz C. Tobacco bZIP transcription factor TGA2.2 and related factor TGA2.1 have distinct roles in plant defense responses and plant development. Plant J, 2005, 44:100-113
215. Tor M, Brown D. Cooper A. Woods-Tor A, Sjolander K, Jones JDG, Holub E B. Arabidopsis downy mildew resistance gene RPP27 encodes a receptor-like protein similar to CLAVATA2 and tomato Cf-9. Plant Physiol. 2004, 135:1100-1112
216. Trotochaud A E. Jeong S, Clark S E. CLAVATA3. a multimeric ligand for the CLAVATA1 receptor-kinase. Science, 2000, 289:613-617
217. Uknes S. Dincher S. Friedrich L. Negrotto D. Williams S. Thompson-Taylor H. Potter S. Ward E. Ryals J. Regulation of pathogenesis-related Protein-1a gene expression in tobacco. Plant Cell. 1993. 5:159-169
218. Underwood W. Zhang SQ. He S Y. The Pseudomonas syringae type III effector tyrosine phosphatase HopAOl suppresses innate immunity in Arabidopsis thaliana. Plant J. 2007, 52:658-672
219. van der Biezen E A. Freddie C T. Kahn K. Parker J E. Jones JDG. Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components.Plant J,2002,29:439-451
220.Van Der Biezen E A,Jones JDG.Plant disease-resistance proteins and the gene-for-gene concept.Trends Biochem Sci,1998,23:454-456
221.van der Knaap E,Song W Y,Ruan D L,Sauter M,Ronald P C.Kende H.Expression of a gibberellin-induced leucine-rich repeat receptor-like protein kinase in deepwater rice and its interaction with kinase-associated protein phosphatase.Plant Physiol,1999,120:559-569
222.van der Vossen EAG,van der Voort J,Kanyuka K,Bendahmane A,Sandbrink H.Baulcombe D C,Bakker J,Stiekema W J,Klein-Lankhorst R M.Homologues of a single resistance-gene cluster in potato confer resistance to distinct pathogens:a virus and a nematode.Plant J,2000,23:567-576
223.Verica J A,He Z H.The cell wall-associated kinase(WAK) and WAK-like kinase gene family.Plant Physiol,2002,129:455-459
224.Walker J C,Zhang R.Relationship of a putative receptor protein-kinase from Maize to the S-Locus Glycoproteins of Brassica.Nature,1990,345:743-746
225.Wan J R,Zhang X C,Neece D,Ramonell K M,Clough S,Kim S Y.Stacey M G.Stacey G.A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis.Plant Cell,2008,20:471-481
226.Wang D.Weaver N D.Kesarwani M,Dong X N.Induction of protein secretory pathway is required for systemic acquired resistance.Science.2005.308:1036-1040
227.Wang G L,Song W Y.Ruan D L,Sideris S,Ronald P C.The cloned gene,Xa21.confers resistance to multiple Xanthomonas oryzae pv oryzae isolates in transgenic plants.Mol Plant-Microbe Interact,1996,9:850-855
228.Wang X L.Chory J.Brassinosteroids regulate dissociation of BKI1.a negative regulator of BRI1 signaling,from the plasma membrane.Science.2006.313:1118-1122
229.Wang Y S.Pi L Y.Chen X H,Chakrabarty P K.Jiang J.De Leon A L.Liu G Z.Li L C.Benny U.Oard J,Ronald P C,Song W Y.Rice XA21 binding protein 3 is a ubiquitin ligase required for full Xa21-mediated disease resistance. Plant Cell. 2006, 18:3635-3646
230. Wang Z X, Yano M, Yamanouchi U, Iwamoto M. Monna L, Hayasaka H, Katayose Y. Sasaki T. The Pib gene for rice blast resistance belongs to the nucleotide binding and leucine-rich repeat class of plant disease resistance genes. Plant J, 1999, 19:55-64
231. Wang Z Y, Seto H. Fujioka S, Yoshida S, Chory J. BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature, 2001, 410:380-383
232. Warren R F, Henk A, Mowery P, Holub E, Innes R W. A mutation within the leucine-rich repeat domain of the Arabidopsis disease resistance gene RPS5 partially suppresses multiple bacterial and downy mildew resistance genes. Plant Cell, 1998, 10:1439-1452
233. Weigel R R, Baeuscher C, Pfitzner AJP. Pfitzner U M. NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants. Plant Mol Biol. 2001.46:143-160
234. Weigel R R, Pfitzner U M, Gatz C. Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis. Plant Cell, 2005. 17:1279-1291
235. Westerink N, Brandwagt B F, de Wit P. Joosten M. Cladosporium fulvum circumvents the second functional resistance gene homologue at the Cf-4 locus (Hcr9-4E) by secretion of a stable avr4E isoform. Mol Microbiol. 2004, 54:533-545
236. Whitham S. Dinesh-Kumar S P, Choi D. Hehl R. Con- C. Baker B. The product of the tobacco mosaic virus resistance gene A': similarity to toll and the interleukin-1 receptor. Cell, 1994. 78:1101 -1115
237. Wildermuth M C. Dewdney J. Wu G, Ausubel F M. Isochorismate synthase is required to synthesize salicylic acid for plant defence. Nature. 2001. 414:562-565
238. Xiang T T. Zong N. Zou Y. Wu Y. Zhang J. Xing W M, Li Y. Tang X Y Zhu L H. Chai J J. Zhou J M. Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol. 2008. 18:74-80
239.Xiao S,Ellwood S,Calis O,Patrick E,Li T,Coleman M.Turner J G.Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8.Science.2001,291:118-120
240.Xing W,Zou Y,Liu Q,Liu J N,Luo X,Huang Q Q,Chen S,Zhu L H,Bi R C,Hao Q,Wu J W,Zhou J M,Chai J J.The structural basis for activation of plant immunity by bacterial effector protein AvrPto.Nature,2007,449:243-247
241.Xu W H,Wang Y S,Liu G Z,Chen X H.Tinjuangjun R Pi L Y,Song W Y.The autophosphorylated Ser686,Thr688,and Ser689 residues in the intracellular juxtamembrane domain of XA21 are implicated in stability control of rice receptor-like kinase.Plant J,2006,45:740-751
242.Yahiaoui N,Srichumpa P,Dudler R,Keller B.Genome analysis at different ploidy levels allows cloning of the powdery mildew resistance gene Pm3b from hexaploid wheat.Plant J,2004,37:528-538
243.Yamaguchi T,Yamada A,Hong N,Ogawa T,Ishii T.Shibuya N.Differences in the recognition of glucan elicitor signals between rice and soybean:beta-glucan fragments from the rice blast disease fungus Pyricularia oryzae that elicit phytoalexin biosynthesis in suspension-cultured rice cells.Plant Cell.2000.12:817-826
244.Yang B,Sugio A,White F F.Os8N3 is a host disease-susceptibility gene for bacterial blight office.Proc Natl Acad Sci USA.2006.10310503-10508
245.Yin Y H,Wang Z Y,Mora-Garcia S.Li J M,Yoshida S,Asami T.Chory J.BES1accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation.Cell.2002.109:181 - 191
246.Yoshimura S,Yamanouchi U,Katayose Y.Toki S.Wang Z X.Kono I.Kurata N.Yano M.Iwata N,Sasaki T.Expression of Xa1,a bacterial blight-resistance gene in rice.is induced by bacterial inoculation.Proc Nail Acad Sci USA,1998.95:1663-1668
247.Yuan J.He SY.The Pseudomonas syringae hrp regulation and secretion system controls the production and secretion of multiple extracellular proteins.J Bacteriol.1996.178:6399-6402
248.Yuan Q P,Shu O Y,Wang A H,Zhu W,Maiti R,Lin H N,Hamilton J,Haas B.Sultana R,Cheung F.Wortman J,Buell C R.The institute for genomic research Osal rice genome annotation database.Plant Physiology,2005,138:17-26
249.Zhang J,Shao F,Cui H,Chen L J,Li H T,Zou Y,Long C Z,Lan L K Chai J J,Chen S.Tang X Y,Zhou J M.A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-Induced immunity in plants.Cell Host Microbe,2007,1:175-185
250.Zhang X C,Gassmann W.Alternative splicing and mRNA levels of the disease resistance gene RPS4 are induced during defense responses.Plant Physiol,2007.145:1577-87
251.Zhao Y F,Thilmony R,Bender C L,Schaller A,He S Y,Howe G A.Virulence systems of Pseudomonas syringae pv.tomato promote bacterial speck disease in tomato by targeting the jasmonate signaling pathway.Plant J,2003,36:485-499
252.Zhou B,Qu S H,Liu G F.Dolan M,Sakai H,Lu G D,Bellizzi M.Wang G L.The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance proteins determine the resistance specificity to Magnaporthe grisea.Mol Plant-Microbe Interact,2006.19:1216-1228
253.Zhou F S,Kurth J C.Wei F S.Elliott C,Vale G,Yahiaoui N,Keller B,Somerville S,Wise R,Schulze-Lefert P.Cell-autonomous expression of barley Mla1 confers race-specific resistance to the powdery mildew fungus via a Rarl-independent signaling pathway.Plant Cell,2001,13:337-350
254.Zhu W G.Yang B,Chittoor J M.Johnson L B,White F F.AvrXa10 contains an acidic transcriptional activation domain in the functionally conserved C terminus.Mol Plant-Microbe Interact.1998.11:824-832
255.Zimmermann P,Hirsch-Hoffmann M.Hennig L,Gruissem W.Arabidopsis microarray database and analysis toolbox.Plant Physiol,2004.136:2621-2632
256.Zipfel C.Felix G.Plants and animals:a different taste for microbes? Curt Opin Plant Biol.2005.8:353-360
257.Zipfel C,Kunze G.Chinchilla D,Caniard A.Jones JDG,Boller T,Felix G.Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell, 2006, 125:749-760
258. Zipfel C, Robatzek S. Navarro L, Oakeley E J, Jones JDG, Felix G, Boiler T. Bacterial disease resistance in Arabidopsis through flagellin perception. Nature, 2004. 428:764-767
259. Zwiesler-Vollick J, Plovanich-Jones A E, Nomura K, Bandyopadhyay S, Joardar V, Kunkel B N. He S Y. Identification of novel hrp-regulated genes through functional genomic analysis of the Pseudomonas syringae pv. tomato DC3000 genome. Mol Microbiol, 2002, 45:1207-1218
2.Abedon B G,Tracy W F.Comgrassl of maize(Zea mavs L) delays development of adult plant resistance to common rust(Puccinia sorghi Schw) and European corn borer(Ostrinia nubilalis hubner).1996,J Hered.87:219-223
3.Abramovitch R B,Janjusevic R,Stebbins C E.Martin G B.Type Ⅲ effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity.Proc Natl Acad Sci USA,2006,103:2851-2856
4.Ade J.DeYoung B J.Golstein C.Innes R W.Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease.Proc Natl Acad Sci USA,2007,104:2531-2536
5.Afzal A J,Wood A J,Lightfoot D A.Plant receptor-like serine threonine kinases:roles in signaling and plant defense.Mol Plant Microbe Interact.2008.21:507-517
6.Aifa S,Aydin J,Nordvall G.Lundstrom I.Svensson SPS.Herrnanson O.A basic peptide within the juxtamembrane region is required for EGF receptor dimerization. Exp Cell Res, 2005, 302:108-114
7. Aifa S, Frikha F, Miled N, Johansen K, Lundstrom I, Svensson SPS. Phosphorylation of Thr(654) but not Thr(669) within the juxtamembrane domain of the EGF receptor inhibits calmodulin binding. Biochem Biophys Res Commun, 2006a. 347:381-387
8. Aifa S, Johansen K. Nilsson UK. Liedberg B, Lundstrom I, Svensson SPS. Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance. Cell Signal, 2002, 14:1005-1013
9. Aifa S, Miled N, Frikha F, Aniba M R. Svensson SPS. Rebai A. Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal growth factor receptor provides a model for intracellular dimerization and autophosphorylation. Proteins. 2006b, 62:1036-1043
10. Anderson P A, Lawrence G J. Morrish B C, Ayliffe M A, Finnegan E J, Ellis JG (1997) Inactivation of the Flax Rust Resistance Gene M Associated with Loss of a Repeated Unit within the Leucine-Rich Repeat Coding Region. Plant Cell 9: 641-651
11. Asai T, Tena G, Plotnikova J. Willmann M R. Chiu W L, Gomez-Gomez L, Boiler T. Ausubel F M. Sheen J. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature, 2002. 415:977-983
12. Assmann S M. G protein regulation of disease resistance during infection of rice with rice blast fungus. Sci STKE. 2005. 310:cm13.
13. Axtell M J, Staskawicz B J. Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4. Cell. 2003 112:369-377
14. Ballvora A. Ercolano M R. Weiss J. Meksem K. Bormann C A. Oberhagemann P. Salamini F, Gebhardt C. The R1 gene for potato resistance to late blight (Phytophthora infest am) belongs to the leucine zipper/NBS/LRR class of plant resistance genes. Plant J. 2002. 30:361-371
15. Becraft P W. Stinard P S. McCarty D R. CRINKLY4: A TNFR-like receptor kinase involved in maize epidermal differentiation. Science. 1996. 273:1406-1409
16.Belkhadir Y,Nimchuk Z,Hubert D A.Mackey D,Dangl J L.Arabidopsis RIN4negatively regulates disease resistance mediated by RPS2 and RPM1 downstream or independent of the NDR1 signal modulator and is not required for the virulence functions of bacterial type Ⅲ effectors AvrRpt2 or AvrRpml.Plant Cell,2004.16:2822-2835
17.Bendahmane A,Kanyuka K,Baulcombe D C.The Rx gene from potato controls separate virus resistance and cell death responses.Plant Cell,1999,11:781-791
18.Bent A F,Kunkel B N,Dahlbeck D,Brown K L,Schmidt R,Giraudat J,Leung J,Staskawicz B J.Rps2 of Arabidopsis Thaliana - a Leucine-Rich Repeat Class of Plant-Disease Resistance Genes.Science,1994,265:1856-1860
19.Bittner-Eddy P D,Crute I R,Holub E B,Beynon J L.RPP13 is a simple locus in Arabidopsis thaliana for alleles that specify downy mildew resistance to different avirulence determinants in Peronospora parasitica.Plant J,2000.21:177-188
20.Bleecker A B,Kende H.Ethylene:A gaseous signal molecule in plants.Annu Rev Cell Dev Biol,2000,16:1-18
21.Botella M A,Parker J E,Frost L N.Bittner-Eddy P D,Beynon J L.Daniels M J.Holub E B,Jones JDG.Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasitica avirulence determinants.Plant Cell.1998,10:1847-1860
22.Boyes D C.Nam J.Dangl J L.The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response.Proc Natl Acad Sci USA,1998,95:15849-15854
23.Brommonschenkel S H,Frary A,Frary A,Tanksley S D.The broad-spectrum tospovirus resistance gene Sw-5 of tomato is a homolog of the root-knot nematode resistance gene Mi.Mol Plant-Microbe Interact.2000,13:1130-1138
24.Brooks D M.Bender C L.Kunkel B N.The Pseudomonas svringae phytotoxin coronatine promotes virulence by overcoming salicylic acid-dependent defences in Arabidopsis thaliana.Mol Plant Pathol.2005,6:629-639
25. Brueggeman R, Rostoks N, Kudrna D, Kilian A, Han F, Chen J, Druka A, Steffenson B. Kleinhofs A. The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinases. Proc Natl Acad Sci USA. 2002. 99:9328-9333
26. Bryan G T, Wu K S, Farrall L, Jia Y L. Hershey H P, McAdams S A. Faulk K N. Donaldson G K, Tarchini R, Valent B. A single amino acid difference distinguishes resistant and susceptible alleles of the rice blast resistance gene Pi-ta. Plant Cell, 2000. 12:2033-2045
27. Burch-Smith T M. Schiff M, Caplan J L, Tsao J, Czymmek K, Dinesh-Kumar S P. A novel role for the TIR domain in association with pathogen-derived elicitors. Plos Biol. 2007. 5:501-514
28. Buschges R, Hollricher K. Panstruga R, Simons G, Wolter M. Frijters A. van Daelen R. van der Lee T. Diergaarde P. Groenendijk J, Topsch S. Vos P. Salamini F. Schulze-Lefert P. The barley Mlo gene: a novel control element of plant pathogen resistance. Cell 1997. 88:695-705
29. Cai D. Kleine M. Kifle S, Harloff H J, Sandal N N. Marcker K A. Klein-Lankhorst R M. Salentijn EMJ. Lange W, Stiekema W J. Wyss U, Grundler FMW. Jung C. Positional Cloning of a Gene for Nematode Resistance in Sugar Beet. Science. 1997. 275:832-834
30. Cameron R K. Zaton K. Intercellular salicylic acid accumulation is important for age-related resistance in Arabidopsis to Pseudomonas syringae. Physiol Mol Plant Pathol, 2004. 65:197-209
31. Cao H. Glazebrook J. Clarke J D, Volko S. Dong X N. The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cell. 1997.88:57-63
32. Cao Y L. Ding X H. Cai M. Zhao J. Lin Y J. Li X H. Xu C G. Wang S P. Expression pattern of a rice disease resistance gene Xa3/Xa26 is differentially regulated by the genetic backgrounds and developmental stages that influence its function. Genetics. 2007, 177:523-533
33. Century K S, Lagman R A. Adkisson M. Morlan J. Tobias R. Schwartz K. Smith A, Love J, Ronald P C. Whalen M C. Developmental control of Xa21-mediated disease resistance in rice. Plant J, 1999, 20:231-236
34. Che F S, Nakajima Y, Tanaka N, Iwano M, Yoshida T, Takayama S. Kadota I. Isogai A. Flagellin from an incompatible strain of Pseudomonas avenae induces a resistance response in cultured rice cells. J Biol Chem, 2000, 275:32347-32356
35. Chen X W, Shang J J, Chen D X, Lei C L, Zou Y, Zhai W X. Liu G Z. Xu J C, Ling Z Z, Cao G, Ma B T, Wang Y P, Zhao X F, Li S G, Zhu L H. A B-lectin receptor kinase gene conferring rice blast resistance. Plant J, 2006, 46:794-804
36. Chen Z Y, Agnew J L, Cohen J D, He P, Shan L B. Sheen J. Kunkel B N. Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology. Proc Natl Acad Sci USA, 2007, 104:20131-20136
37. Chern M, Canlas P E, Fitzgerald H A, Ronald P C. Rice NRR. a negative regulator of disease resistance, interacts with Arabidopsis NPR1 and rice NH1. Plant J, 2005a, 43:623-635
38. Chern M, Fitzgerald H A, Canlas P E, Navarre D A, Ronald P C. Overexpression of a rice NPR1 homolog leads to constitutive activation of defense response and hypersensitivity to light. Mol Plant-Microbe Interact. 2005b. 18:511-520
39. Chern M S, Song W Y. Pi L Y, Yadav R. Hr Z, Zhang Y. Dong X N and Ronald P C. Signaling in rice disease resistance. In: PJGM de Wit. Bisseling T. and Stikema W J. eds.. Biology of plant microbe interactions. vol2. St. Paul. MN. USA. 2000.254-258
40. Chester S. The problem of acquired physiological immunity in plants. Quar Rev Biol. 1933.8:129-154
41. Chinchilla D. Bauer Z. Regenass M. Boiler T. Felix G. The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception. Plam Cell, 2006, 18:465-476
42.Chinchilla D.Zipfel C,Robatzek S,Kemmerling B,Nurnberger T,Jones JDG,Felix G.Boller T.A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence.Nature,2007,448:497-500
43.Chintamanani S.Multani D S,Ruess H.Johal G S.Distinct mechanisms govern the dosage-dependent and developmentally regulated resistance conferred by the maize Hm2 gene.Mol Plant-MicrObe Interact.2008,21:79-86
44.Chu Z H,Yuan M,Yao J L,Ge X J,Yuan B,Xu C G.Li X H,Fu B y,Li Z K,Bennetzen J L,Zhang Q F,Wang S P.Promoter mutations of an essential gene for pollen development result in disease resistance in rice.Gene Dev,2006,20:1250-1255
45.Clark S E,Williams R W.Meyerowitz E M.The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis.Cell,1997.89:575-585
46.Coaker G,Falick A,Staskawicz B.Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin.Science,2005,308:548-550
47.Collins N,Drake J,Ayliffe M,Sun Q,Ellis J.Hulbert S,Pryor T.Molecular characterization of the maize Rp1-D rust resistance haplotype and its mutants.Plant Cell,1999,11:1365-1376
48.Cooley M B,Pathirana S,Wu H J.Kachroo P.Klessig D F.Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and oomycete pathogens.Plant Cell,2000,12:663-676
49.Cooper B.Clarke J D.Budworth P,Kreps J.Hutchison D.Park S,Guimil S.Dunn M.Luginbuhl P.Ellero C.Goff S A.Glazebrook J.A network of rice genes associated with stress response and seed development.Proc Natl Acad Sci USA.2003.100:4945-4950
50.Cote F.Roberts K A.Hahn M G.Identification of high-affinity binding sites for the hepta-beta-glucoside elicitor in membranes of the model legumes Medicago truncatula and Lotus japonicus.Planta.2000.211:596-605
51.Craddock B P.Cotter C.Miller W T.Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region.Febs Lett,2007.581:3235-3240
52.de Majnik J,Ogbonnaya F C,Moullet O,Eagudah E S.The Crel and Cre3 nematode resistance genes are located at homeologous loci in the wheat genome.Mol Plant-Microbe Interact,2003,16:1129-1134
53.de Torres-Zabala M,Truman W,Bennett M H,Lafforgue G,Mansfield J W,Egea P R.Bogre L,Grant M.Pseudomonas syringae pv.tomato hijacks the Arabidopsis abscisic acid signalling pathway to cause disease.Embo J.2007.26:1434-1443
54.Deslandes L,Olivier J,Peeters N,Feng D X,Khounlotham M,Boucher C,Somssich L,Genin S,Marco Y.Physical interaction between RRS1-R,a protein conferring.resistance to bacterial wilt,and PopP2,a type Ⅲ effector targeted to the plant nucleus.Proc Natl Acad Sci USA,2003,100:8024-8029
55.Deslandes L,Olivier J,Theulieres F.Hirsch J,Feng D X,Bittner-Eddy R Beynon J,Marco Y.Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene,a member of a novel family of resistance genes.Proc Natl Acad Sci USA,2002,99:2404-2409
56.Despres C,Chubak C,Rochon A,Clark R,Bethune T,Desveaux D,Fobert P R.The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1.Plant Cell,2003,15:2181-2191
57.Deverall B J.In:Brian P W,Pringle JWS.Defense Mechanisms of Plants.vol 19.Cambridge University Press.1977
58.Diener A C,Ausubel F M.Resistance to fusarium oxysporum 1,a dominant Arabidopsis disease-resistance gene.is not race specific.Genetics.2005,171:305-321
59.Ding X H.Cao Y L,Huang L L.Zhao J.Xu C G.Li X H,Wang S R Activation of the indole-3-acetic acid-amido synthetase GH3-8 suppresses expansin expression and promotes salicylate- and jasmonate-independent basal immunity in rice.Plant Cell.2008.20:228-240
60.Dixon M S.Hatzixanthis K.Jones D A.Harrison K.Jones J D.The tomato Cf-5 disease resistance gene and six homologs show pronounced allelic variation in leucine-rich repeat copy number. Plant Cell 1998, 10:1915-1925
61. Dixon M S, Jones D A, Keddie J S. Thomas C M, Harrison K, Jones J D. The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine-rich repeat proteins. Cell, 1996, 84:451-459
62. Dodds P N, Lawrence G J, Catanzariti A M, Teh T, Wang CIA, Ayliffe M A. Kobe B, Ellis J G. Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes. Proc Natl AcadSci USA, 2006, 103:8888-8893
63. Dodds P N, Lawrence G J, Ellis J G. Six Amino Acid Changes Confined to the Leucine-Rich Repeat P-Strand/p-Turn Motif Determine the Difference between the P and P2 Rust Resistance Specificities in Flax. Plant cell, 2001, 13:163-178
64. Dong X N. NPR1, all things considered. Curr Opin Plant Biol, 2004, 7:547-552
65. Eckardt N A. Mechanism of Pto-mediated disease resistance: Structural analysis provides a new model. Plant Cell, 2004, 16:2543-2545
66. Eitas T K, Nimchukt Z L. Dangl J L. Arabidopsis TA01 is a TIR-NB-LRR protein that contributes to disease resistance induced by the Pseudomonas syringae effector AvrB. Proc Natl Acad Sci USA. 2008, 105:6475-6480
67. Ellis J G, Lawrence G J. Luck J E, Dodds P N. Identification of regions in alleles of the flax rust resistance gene L that determine differences in gene-for-gene specificity. Plant Cell 1999. 11:495-506
68. Ernst K. Kumar A. Kriseleit D. Kloos D U. Phillips M S. Ganal M W. The broad-spectrum potato cyst nematode resistance gene (Hero) from tomato is the only member of a large gene family of NBS-LRR genes with an unusual amino acid repeat in the LRR region. Plant J. 2002. 31:127-136
69. Faigon-Soverna A. Harmon F G Storani L. Karayekov E. Staneloni R J. Gassmann W. Mas P. Casal J J. Kay S A. Yanovsky M J. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell 2006, 18:2919-2928
70. Falk A, Feys B J. Frost L N. Jones JDG. Daniels M J. Parker J E. EDS1. an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases. Proc Natl Acad Sci USA, 1999. 96:3292-3297
71. Felix G. Boiler T. Molecular sensing of bacteria in plants - The highly conserved RNA-binding motif RNP-1 of bacterial cold shock proteins is recognized as an elicitor signal in tobacco. J Biol Chem, 2003, 278:6201-6208
72. Felix G, Duran J D, Volko S, Boiler T. Plants have a sensitive perception system for the most conserved domain of bacterial flagellin. Plant J, 1999a. 18:265-276
73. Feuillet C, Travella S, Stein N, Albar L, Nublat A. Keller B. Map-based isolation of the leaf rust disease resistance gene Lr10 from the hexaploid wheat (Triricum aestivum L.) genome. Proc Natl Acad Sci USA, 2003, 100:15253-15258
74. Feys B J, Moisan L J. Newman M A, Parker J E. Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4. Embo J. 2001. 20:5400-5411
75. Fliegmann J, Mithofer A. Wanner G, Ebel J. An ancient enzyme domain hidden in the putative beta-glucan elicitor receptor of soybean may piay an active part in the perception of pathogen-associated molecular patterns during broad host resistance. .J Biol Chem, 2004. 279:1132-1140
76. Fliegmann J. Montel E. Djulic A. Cottaz S, Driguez H. Ebel M G. Catalytic properties of the bifunctional soybean beta-glucan-binding protein. a member of family 81 glycoside hydrolases. Febs Lett. 2005, 579:6647-6652
77. Fodor J, Gullner G. Adam A L. Barna B, Komives T. Kiraly Z. Local and Systemic Responses of Antioxidants to Tobacco Mosaic Virus Infection and to Salicylic Acid in Tobacco (Role in Systemic Acquired Resistance). Plant Physiol. 1997. 114:1443-1451
78. Forouhar F. Yang Y. Kumar D. Chen Y. Fridman E. Park S W. Chiang Y. Acton T B. Montelione G T. Pichersky E. Klessig D F. Tong L. Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity.Proc Natl Acad Sci USA,2005,102:1773-1778
79.Fu Z Q,Guo M,Jeong B R,Tian F,Elthon T E,Cerny R L.Staiger D,Alfano J R.A type Ⅲ effector ADP-ribosylates RNA-binding proteins and quells plant immunity.Nature,2007,447:284-288
80.Gabriel D W.Rolfe B G.Working Models of Specific Recognition in Plant-Microbe Interactions.Annu Rev Phytopathol,1990,28:365-391
81.Gaffney T,Friedrich L,Vemooij B,Negrotto D,Nye G,Uknes S,Ward E,Kessmann H,Ryals J.Requirement of salicylic acid for the induction of systemic acquired resistance.Science,1993,261:754-756
82.Galiana E,Riviere M P,Pagnotta S,Baudouin E,Panabieres F,Gounon P,Boudier L.Plant-induced cell death in the oomycete pathogen Phytophthora parasitica.Cellular Microbiol,2005,7:1365-1378
83.Gassmann W.Hinsch M E,Staskawicz B J.The Arabidopsis RPS4bacterial-resistance gene is a member of the TIR-NBS-LRR family of disease-resistance genes.Plant J,1999,20:265-277
84.Geldner N,Hyman D L,Wang X L,Schumacher K.Chory J.Endosomal signaling of plant steroid receptor kinase BRI1.Gene Dev,2007.21:1598-1602
85.Geldner N,Jurgens G.Endocytosis in signalling and development.Curr Opin Plant Biol.2006,9:589-594
86.Godiard L.Sauviac L,Torii KU,Grenon O.Mangin B,Grimsley N H,Marco Y.ERECTA.an LRR receptor-like kinase protein controlling development pleiotropically affects resistance to bacterial wilt.Plant J.2003.36:353-365
87.Goggin F L,Shah G,Williamson V M,Ullman D E.Developmental regulation of Mi-mediated aphid resistance is independent of Mi-1.2 transcript levels.Mol Plant-Microbe Interact.2004,17:532-536
88.Gomez-Gomez L,Boiler T.FLS2:An LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis.Mol Cell,2000.5:1003-1011
89.Gomez-Gomez L,Boller T.Flagellin perception:a paradigm for innate immunity.Trends Plant Sci,2002,7:251-256
90.Gouger A,Senchou V,Govers F,Sanson A.Barre A,Rouge P.Pont-Lezica R,Canut H.Lectin receptor kinases participate in protein-protein interactions to mediate plasma membrane-cell wall adhesions in Arabidopsis.Plant Physiol,2006,140:81-90
91.Grant M R,Godiard L,Straube E,Ashfield T.Lewald J.Sattler A,Innes R W,Dangl J L.Structure of the Arabidopsis Rpm1 gene enabling dual-specificity disease resistance.Science,1995,269:843-846
92.Gu K Y,Sangha J S,Li Y,Yin Z C.High-resolution genetic mapping of bacterial blight resistance gene Xa10.Theor Appl Genet.2008,116:155-163
93.Gu K Y,Yang B,Tian D S,Wu L F.Wang D J,Sreekala C,Yang F.Chu Z Q,Wang G L,White F F,Yin Z C.R gene expression induced by a type-Ⅲ effector triggers disease resistance in rice.Nature,2005,435:1122-1125
94.Guttman D S,Vinatzer B A,Sarkar S F.Ranall M V.Kettler G.Greenberg J T.A functional screen for the type Ⅲ(Hrp) secretome of the plant pathogen Pseudomonas syringae.Science,2002,295:1722-1726
95.Halterman D,Zhou F S,Wei F S,Wise R P.Schulze-Lefert P.The MICA6 coiled-coil,NBS-LRR protein confers AvrMla6-dependent resistance specificity to Blumeria graminis f.sp hordei in barley and wheat.Plant J,2001,25:335-348
96.Halterman D A,Wise R P.A single-amino acid substitution in the sixth leucine-rich repeat of barley MLA6 and MLA13 alleviates dependence on RAR1 for disease resistance signaling.Plant J,2004.38:215-226
97.Hann D R.Rathjen J P.Early events in the pathogenicity of Pseudomonas syringae on Nicotiana benthamiana.Plant J,49:607-618
98.Haubrick L L,Assmann S M.Brassinosteroids and plant function:some clues,more puzzles.Plant Cell Environ.2006.29:446-457
99.Hauck P.Thilmony R.He S Y.A Pseudomonas syringae type Ⅲ effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants.Proc Natl Acad Sci USA, 2003, 100:8577-8582
100. He J X, Gendron J M, Sun Y, Gampala SSL, Gendron N, Sun C Q. Wang Z Y. BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science, 2005, 307:1634-1638
101. He K, Gou X P, Yuan T, Lin H H, Asami T. Yoshida S. Russell S D. Li J. BAK1 and BKK1 regulate Brassinosteroid-dependent growth and Brassinosteroidlndependent cell-death pathways. Curr Biol, 2007, 17:1109-1115
102. He P, Shan L, Lin N C, Martin G B, Kemmerling B, Nurnberger T, Sheen J. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell, 2006, 125:563-575
103. He Z H, He D Z, Kohorn B D. Requirement for the induced expression of a cell wall associated receptor kinase for survival during the pathogen response. Plant J. 1998, 14:55-63
104. He Z H, Wang Z Y. Li J M, Zhu Q. Lamb C, Ronald P C, Chory J. Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science. 2000, 288:2360-2363
105. Hepworth S R, Zhang Y L. McKim S, Li X, Haughn G. BLADE-ON-PET1OLE -dependent signaling controls leaf and floral patterning in Arabidopsis. Plant Cell. 2005, 17:1434-1448
106. Herve C, Dabos P. Galaud JP. Rouge P. Lescure B. Characterization of an Arabidopsis thaliana gene that defines a new class of putative plant receptor kinases with an extracellular lectin-like domain. J Mol Biol. 1996, 258:778-788
107. Horton R M, Hunt H D. Ho S N. Pullen J K. Pease L R. Engineering hybrid genes without the use of restriction enzymes, gene-splicing by overlap extension. Gene. 1989,77:61-68
108. Inoue T, Higuchi M. Hashimoto Y. Seki M. Kobayashi M. Kato T, Tabata S. Shinozaki K. Kakimoto T. Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature. 2001, 409:1060-1063
109. Iyer A S, McCouch S R. The rice bacterial blight resistance gene xa5 encodes a novel form of disease resistance. Mol Plant-Microbe Interact, 2004, 17:1348-1354
110. Jablonska B. Ammiraju JSS. Bhattarai K K. Mantelin S. de Ilarduya O M, Roberts P A. Kaloshian I. The Mi-9 gene from Solanum arcanum conferring heat-stable resistance to root-knot nematodes is a homolog of Mi-1. Plant Physiol, 2007. 143:1044-1054
111. Janjusevic R, Abramovitch R B. Martin G B, Stebbins C E. A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase. Science, 2006. 311:222-226
112. Jelenska J, Yao N, Vinatzer B A, Wright C M, Brodsky J L, Greenberg J T. A J domain virulence effector of Pseudomonas syringae remodels host chloroplasts and suppresses defenses. Curr Biol, 2007. 17:499-508
113. Jeong S, Trotochaud A E. Clark S E. The Arabidopsis CLAVATA2 gene encodes a receptor-like protein required for the stability of the CLAVATA1 receptor-like kinase. Plant Cell, 1999. 11:1925-1933
114. Jia Y, McAdams S A. Bryan G T, Hershey H P, Valent B. Direct interaction of resistance gene and avirulence gene products confers rice blast resistance. Embo J. 2000, 19:4004-4014
115. Jirage D. Tootle T L. Reuber T L, Frost L N. Feys B J, Parker J E. Ausubel F M. Glazebrook J. Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling. Proc Natl Acad Sci USA. 1999. 96:13583-13588
116. Jones D A, Thomas C M. Hammond-Kosack K E. Balint-Kurti P J. Jones J D. Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science. 1994. 266:789-793
117. Kachroo P. Shanklin J. Shah J. Whittle E J. Klessig D F. A fatty acid desaturase modulates the activation of defense signaling pathways in plants. Proc Natl Acad Sci USA, 2001. 98:9448-9453
118. Kaku H, Nishizawa Y. Ishii-Minami N. Akimoto-Tomiyama C. Dohmae N. Takio K. Minami E. Shibuva N. Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor.Proc Natl Acad Sci USA.2006,103:11086-11091
119.Kawchuk L M,Hachey J,Lynch D R,Kulcsar F,van Rooijen G.Waterer D R.Robertson A,Kokko E,Byers R,Howard R J,Fischer R,Prufer D.Tomato Ve disease resistance genes encode cell surface-like receptors.Proc Natl Acad Sci USA,2001.98:6511-6515
120.Kim H S,Desveaux D,Singer A U,Patel P,Sondek J,Dangl J L.The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target,RIN4,from Arabidopsis membranes to block RPM1 activation.Proc Natl Acad Sci USA,2005,102:6496-6501
121.Kinoshita T,Cano-Delgado A C,Seto H,Hiranuma S,Fujioka S,Yoshida S.Chory J.Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1.Nature,2005,433:167-171
122.Kumar D,Gustafsson C,Klessig D F.Validation of RNAi silencing specificity using synthetic genes:salicylic acid-binding protein 2 is required for innate immunity in plants.Plant J,2006.45:863-868
123.Kunze G,Zipfel C,Robatzek S,Niehaus K,Boller T,Felix G.The N terminus of bacterial elongation factor Tu elicits innate immunity in Arabidopsis plants.Plant Cell 2004,16:3496-3507
124.Kus J V,Zaton K,Sarkar R.Cameron R K.Age-related resistance in Arabidopsis is a developmentally regulated defense response to Pseudomonas syringae.Plant Cell.2002.14:479-490
125.Lagudah E S.Moullet O,Appels R.Map-based cloning of a gene sequence encoding a nucleotide-binding domain and a leucine-rich region at the Cre3 nematode resistance locus of wheat.Genome.1997,40:659-665
126.Lawrence G J.Finnegan E J.Ayliffe M A,Ellis J G.The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N.Plant Cell.1995,7:1195-1206
127.Leisner S M,Turgeon R,Howell S H.Effects of host plant development and genetic-determinants on the long-distance movement of cauliflower mosaic-virus in Arabidopsis.Plant Cell,1993,5:191-202
128.Lenhard M,Laux T.Stem cell homeostasis in the Arabidopsis shoot meristem is regulated by intercellular movement of CLAVATA3 and its sequestration by CLAVATA1.Development,2003,130:3163-3173
129.Li J M,Chory J.A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction.Cell,1997,90:929-938
130.Li J M,Nam K H.Regulation of brassinosteroid signaling by a GSK3/SHAGGY-like kinase.Science,2002.295:1299-1301
131.Li J M,Nam K H,Vafeados D,Chory J.BIN2,a new brassinosteroid-insensitive locus in Arabidopsis.Plant Physiol,2001.127:14-22
132.Li S Q,Covino N D.Stein E G.Till J H.Hubbard S R.Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.J Biol Chem,2003,278:26007-26014
133.Li X Y.Lin H Q,Zhang W G,Zou Y,Zhang J,Tang X Y.Zhou J M.Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors.Proc Natl Acad Sci USA,2005,102:12990-12995
134.Lin F.Chen S.Que Z Q,Wang L,Liu X Q,Pan Q H.The blast resistance gene Pi37encodes a nucleotide binding site-leucine-rich repeat protein and is a member of a resistance gene cluster on rice chromosome 1.Genetics.2007.177:1871-1880
135.Lindgren P B.The role of hrp genes during plant-bacterial interactions.Annu Rev Phytopathol,1997.35:129-152
136.Liu G Z,Pit L Y,Walker J C,Ronald P C.Song W Y.Biochemical characterization of the kinase domain of the rice disease resistance receptor-like kinase XA21.J Biol Chem.2002.277:20264-20269
137.Liu K D.Wang J.Li H B,Xu C G.Liu A M,Li X H.Zhang Q.A genome-wide analysis of wide compatibility in rice and the precise location of the S5 locus in the molecular map. Theor Appl Genet, 1997, 95:809-814
138. Liu X Q, Lin F, Wang L. Pan Q H. The in silico map-based cloning of Pi36. a rice coiled-coil-nucleotide-binding site-leucine-rich repeat gene that confers race-specific resistance to the blast fungus. Genetics. 2007, 176:2541-2549
139. Liu Y, Schiff M, Czymmek K. Talloczy Z, Levine B, Dinesh-Kumar S P. Autophagy regulates programmed cell death during the plant innate immune response. Cell. 2005. 121:567-577
140. Llorente F, Alonso-Blanco C, Sanchez-Rodriguez C, Jorda L, Molina A. ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resistance to the necrotrophic fungus Plectosphaerella cucumerina. Plant J, 2005, 43:165-180
141. Lotan T, Ori N, Fluhr R. Pathogenesis-related proteins are developmentally regulated in Tobacco flowers. Plant Cell. 19891:881-887
142. Mackey D, Holt B F, Wiig A, Dangl J L. RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis. Cell, 2002, 108:743-754
143. Maldonado A M, Doerner P, Dixon R A. Lamb C J, Cameron R K. A putative lipid transfer protein involved in systemic resistance signalling in Arabidopsis. Nature. 2002,419:399-403
144. Marois E, Van den Ackerveken G, Bonas U. The Xanthomonas type III effector protein AvrBs3 modulates plant gene expression and induces cell hypertrophy in the susceptible host. Mol Plant-Microbe Interact. 2002, 15:637-646
145. Martin G B. Brommonschenkel S H. Chunwongse J, Frary A. Ganal M W, Spivey R. Wu T, Earle E D, Tanksley S D. Map-based cloning of a protein kinase gene conferring disease resistance in tomato. Science. 1993, 262:1432-1436
146. Martin G B, Frary A, Wu T. Brommonschenkel S. Chunwongse J, Earle E D. Tanksley S D. Member of the Tomato Pto Gene Family Confers Sensitivity to Fenthion Resulting in Rapid Cell Death. Plant Cell, 1994, 6:1543-1552
147. Martinez C, Pons E, Prats G. Leon J. Salicylic acid regulates flowering time and links defence responses and reproductive development. Plant J, 2004, 37:209-217
148. McCarty D R, Chory J. Conservation and innovation in plant signaling pathways. Cell. 2000, 103:201-209
149. McDowell J M, Dhandaydham M. Long T A, Aarts MGM. Goff S, Holub E B. Dangl J L. Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis. Plant Cell, 1998. 10:1861-1874
150. McDowell J M, Williams S G, Funderburg N T. Eulgem T, Dangl J L. Genetic analysis of developmentally regulated resistance to downy mildew (Hyaloperonospora parasitica) in Arabidopsis thaliana. Mol Plant-Microbe Interact, 2005, 18:1226-1234
151. Melotto M, Underwood W, Koczan J, Nomura K, He S Y. Plant stomata function in innate immunity against bacterial invasion. Cell, 2006, 126:969-980
152. Meszaros T, Heifer A. Hatzimasoura E, Magyar Z. Serazetdinova L, Rios G, Bardoczy V, Teige M, Koncz C, Peck S, Bogre L. The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin. Plant J, 2006. 48:485-498
153. Mew T W, Vera Cruz C M and Reyes R C. Characterization of Resistance in Rice to Bacterial Blight. 1980, IRRI, Los Banos. Lagura Philippines
154. Meyers B C, Chin D B. Shen K A. Sivaramakrishnan S. Lavelle D O, Zhang Z. Michelmore R W. The major resistance gene cluster in lettuce is highly duplicated and spans several megabases. Plant Cell 1998, 10:1817-1832
155. Milligan S B, Bodeau J. Yaghoobi J. Kaloshian I. Zabel P. Williamson V M. The root knot nematode resistance gene Mi from tomato is a member of the leucine zipper. nucleotide binding, leucine-rich repeat family of plant genes. Plant Cell, 1998. 10:1307-1319
156. Miya A. Albert P. Shinya T. Desaki Y. Ichimura K. Shirasu K. Narusaka Y. Kawakami N. Kaku H. Shibuya N. CERK1. a LysM receptor kinase. is essential for chitin elicitor signaling in Arabidopsis. Proc Natl Acad Sci USA. 2007. 104:19613-19618
157. Moose S P. Sisco P H. Glossy 15 Controls the Epidermal Juvenile-to-Adult Phase-Transition in Maize. Plant Cell, 1994, 6:1343-1355
158. Morillo S A, Tax F E. Functional analysis of receptor-like kinases in monocots and dicots. Curr Opin Plant Biol 2006, 9:460-469
159. Mou Z, Fan W H. Dong X N. Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes. Cell, 2003. 113:935-944
160. Muller R, Bleckmann A. Simon R. The receptor kinase CORYNE of Arabidopsis transmits the stem cell-limiting signal CLAVATA3 independently of CLAVATA1. Plant Cell, 2008, 20:934-946
161. Nam K H, Li J M. BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell, 2002. 110:203-212
162. Nandi A, Krothapaili K, Buseman C M, Li M Y, Welti R, Enyedi A. Shah J. Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Plant Cell, 2003, 15:2383-2398
163. Nandi A, Welti R, Shah J. The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. Plant Cell. 2004, 16:465-477
164. Ni C Y. Murphy M P, Golde T E, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science. 2001. 294:2179-2181
165. Nielsen M E, Lok F. Nielsen H B. Distinct developmental defense activations in barley embryos identified by transcriptome profiling. Plant Mol Biol. 2006. 61:589-601
166. Nomura K, DebRoy S. Lee Y H. Pumplin N. Jones J. He S Y A bacterial virulence protein suppresses host innate immunity to cause plant disease. Science. 2006.313:220-223
167. Ori N. Eshed Y, Paran I. Presting G Aviv D. Tanksley S D. Zamir D. Fluhr R. The 12C family from the wilt disease resistance locus I2 belongs to the nucleotide binding.leucine-rich repeat superfamily of plant resistance genes.Plant Cell,1997.9:521-532
168.Panter S N,Hammond-Kosack K E,Harrison K,Jones JDG,Jones D A.Developmental control of promoter activity is not responsible for mature onset of Cf-9B-mediated resistance to leaf mold in tomato.Mol Plant-Microbe Interact.2002,15:1099-1107
169.Park S W,Kaimoyo E,Kumar D,Mosher S,Klessig D F.Methyl salicylate is a critical mobile signal for plant systemic acquired resistance.Science,2007.318:113-116
170.Parker J E,Coleman M J,Szabo V,Frost L N,Schmidt R,vanderBiezen E A.Moores T,Dean C,Daniels M J,Jones JDG.The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 receptors with N and L6.Plant Cell,1997,9:879-894
171.Pastuglia M,Roby D.Dumas C,Cock J M.Rapid induction by wounding and bacterial infection of an S Gene family receptor-like kinase gene in Brassica oleracea.Plant Cell,1997,9:49-60
172.Peng Y,Bartley L,E.Chen X,Dardick C,Chern M,Ruan R,Canlas P E,Ronald P C.OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas oryzae pv.oryzae in Rice.Mol Plant,2008,1:446-458
173.Peng Y,Park J C,Dardick C.Ruan R and Ronald P C.Xb15 is a negative regulator of Xa21-mediated disease resistance.Abstract,The 5th International rice Genetics Symposium.2005.Manila.Philippines
174.Petnicki-Ocwieja T.Schneider D J.Tam V C,Chancey S T.Shah I,.Jamir Y.Schechter L,M,Janes M D,Buell C R.Fang X,Collmer A,Alfano J R.Genomewide identification of proteins secreted by the Hrp type Ⅲ protein secretion system of Pseudomonas syringae pv.tomato DC3000.Proc Natl Acad Sci USA,2002.99:7652-7657
175.Pieterse CMJ.van Wees SCM.van Pelt J A.Knoester M.Laan R.Gerrits N.Weisbeek P J, van Loon L C. A novel signaling pathway controlling induced systemic resistance in Arabidopsis. Plant Cell, 1998. 10:1571-1580
176. Preston G M, Studholme D J, Caldelari I. Profiling the secretomes of plant pathogenic Proteobacteria. Ferns Microbiol Rev, 2005. 29:331-360
177. Qu S H, Liu G F. Zhou B. Bellizzi M, Zeng L R, Dai L Y. Han B. Wang G L. The broad-spectrum blast resistance gene Pi9 encodes a nucleotide-binding site-leucine-rich repeat protein and is a member of a multigene family in rice. Genetics, 2006, 172:1901 -1914
178. Radwan O, Mouzeyar S, Nicolas P, Bouzidi M F. Induction of a sunflower CC-NBS-LRR resistance gene analogue during incompatible interaction with Plasmopara halstedii. J Exp Bot, 2005, 56:567-575
179. Robatzek S, Chinchilla D, Boiler T. Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. Gene Dev, 2006. 20:537-542
180. Roine E, Wei W S, Yuan J, NurmiahoLassila E L, Kalkkinen N, Romantschuk M, He S Y. Hrp pilus: an hrp-dependent bacterial surface appendage produced by Pseudomonas syringae pv tomato DC3000. Proc Natl Acad Sci USA, 1997, 94:3459-3464
181. Rojo E, Sharma V K, Kovaleva V, Raikhel N V. Fletcher J C. CLV3 is localized to the extracellular space, where it activates the Arabidopsis CLAVATA stem cell signaling pathway. Plant Cell, 2002, 14:969-977
182. Ron M. Avni A. The receptor for the fungal elicitor ethylene-inducing xylanase is a member of a resistance-like gene family in tomato. Plant Cell. 2004. 16:1604-1615
183. Rooney HCE, van 't Klooster J W. van der Hoorn RAL. Joosten M. Jones JDG. de Wit P. Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science. 2005, 308:1783-1786
184. Russinovaa E, Borst J W. Kwaaitaal M, Cano-Delgado A. Yin Y H. Chory j. de Vries S C. Heterodimerization and endocytosis of Arabidopsis brassinosteroid receptors BR11 and AtSERK3 (BAK1). Plant Cell 2004. 16:3216-3229
185. Rusterucci C. Zhao Z, Haines K, Mellersh D, Neumann A. Cameron R K. Age-related resistance to Pseudomonas syringae pv. tomato is associated with the transition to flowering in Arabidopsis and is effective against Peronospora parasitica. Physiol Mol Plant Pathol. 2005, 66:222-231
186. Salmeron J M, Oldroyd GED, Rommens CMT, Scofield S R. Kim H S. Lavelle D T. Dahlbeck D, Staskawicz B J. Tomato Prf is a member of the leucine-rich repeat class of plant disease resistance genes and lies embedded within the Pto kinase gene cluster. Cell, 1996,86:123-133
187. Salzberg S L, Sommer D D, Schatz M C, Phillippy A M. Rabinowicz P D, Tsuge S. Furutani A, Ochiai H, Delcher A L, Kelley D, Madupu R. Puiu D, Radune D. Shumway M, Trapnell C, Aparna G, Jha G, Pandey A. Patil P B. Ishihara H et al. Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A. BMC Genom, 2008 , 9:204
188. Salzman R A. Tikhonova I, Bordelon B P. Hasegawa P M. Bressan R A. Coordinate accumulation of antifungal proteins and hexoses constitutes a developmentally controlled defense response during fruit ripening in grape. Plant Physiol, 1998. 117:465-472
189. Schoof H, Lenhard M. Haecker A, Mayer KFX. Jurgens G. Laux T. The stem cell population of Arabidopsis shoot meristems is maintained by a regulatory loop between the CLAVATA and WUSCHEL genes. Cell. 2000. 100:635-644
190. Schornack S. Ballvora A. Gurlebeck D, Peart J. Baulcombe D. Ganal M. Baker B. Bonas U. Lahaye T. The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severly truncated derivatives of AvrBs4 and overexpressed AvrBs3. Plant J. 2004. 37:46-60
191. Shang Y L. Li X Y. Cui H T, He P. Thilmony R. Chintamanani S. Zwiesier-Vollick J. Gopalan S. Tang X Y. Zhou J M. RAR1. a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB. Proc \'atl Acad Sci USA. 2006. 103:19200-19205
192. Shen Q H, Saijo Y, Mauch S, Biskup C. Bieri S. Keller B, Seki H. Ulker B, Somssich IE, Schulze-Lefert P. Nuclear activity of MLA immune receptors links isolate-specific and basal disease-resistance responses. Science. 2007, 315:1098-1103
193. Shen Q H, Zhou F S, Bieri S, Haizel T. Shirasu K, Schulze-Lefert P. Recognition specificity and RAR1/SGT1 dependence in barley Mla disease resistance genes to the powdery mildew fungus. Plant Cell. 2003. 15:732-744
194. Shigeoka S, Ishikawa T, Tamoi M, Miyagawa Y, Takeda T, Yabuta Y, Yoshimura K. Regulation and function of ascorbate peroxidase isoenzymes. J Exp Bot, 2002, 53:1305-1319
195. Shirano Y, Kachroo P, Shah J, Klessig D F. A gain-of-function mutation in an Arabidopsis Toll Interleukin-1 Receptor-Nucleotide Binding Site-Leucine-Rich Repeat type R gene triggers defense responses and results in enhanced disease resistance. Plant Cell. 2002, 14:3149-3162
196. Shiu S H, Karlowski W M, Pan R S, Tzeng Y H. Mayer KFX, Li W H. Comparative analysis of the receptor-like kinase family in Arabidopsis and rice. Plant Cell. 2004. 16:1220-1234
197. Sohn K H, Lei R, Nemri A. Jones JDG. The downy mildew effector proteins ATR1 and ATR13 promote disease susceptibility in Arabidopsis thaliana. Plant Cell. 2007. 19:4077-4090
198. Song W Y, Pi L Y, Bureau T E, Ronald P C. Identification and characterization of 14 transposon-like elements in the noncoding regions of members of the Xa21 family of disease resistance genes in rice. Mol Gen Genet. 1998, 258:449-456
199. Song W Y. Pi L Y, Wang G L, Gardner J. Holsten T. Ronald P C. Evolution of the rice Xa21 disease resistance gene family. Plant Cell 1997 9:1279-1287
200. Song W Y, Wang G L. Chen L L, Kim H S. Pi L Y. Holsten T, Gardner J, Wang B. Zhai W X. Zhu L H. Fauquet C. Ronald P C. A receptor kinase-like protein encoded by the rice disease resistance gene. Xa21. Science. 1995. 270:1804-1806
201. Staal J, Kaliff M. Dewaele E. Persson M. Dixelius C. RLM3. a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens.Plant J.2008,55:188-200
202.Suarez-Rodriguez M C,Adams-Phillips L.Liu Y D.Wang H C,Su S H.Jester P J,Zhang S Q,Bent A F,Krysan P J.MEKK1 is required for flg22-induced MPK4activation in Arabidopsis plants.Plant Physiol,2007,143:661-669
203.Sugio A,Yang B,Zhu T,White F F.Two type Ⅲ effector genes of Xanthomonas oryzae pv.oryzae control the induction of the host genes OsTFIIA gamma 1 and OsTFX1 during bacterial blight of rice.Proc Natl Acad Sci USA,2007.104:10720-10725
204.Suharsono U,Fujisawa Y,Kawasaki T,Iwasaki Y,Satoh H,Shimamoto K.The heterotrimeric G protein α subunit acts upstream of the small GTPase Rac in disease resistance of rice.Proc Natl Acad Sci USA.2002,99:13307-13312
205.Sun X L,Cao Y L,Wang S R Point mutations with positive selection were a major force during the evolution of a receptor-kinase resistance gene family of rice.Plant Physiol,2006,140:998-1008
206.Sun X L,Cao Y L,Yang Z F,Xu C G.Li X H,Wang S R Zhang Q F.Xa26,a gene conferring resistance to Xanthomonas orvzae pv.oryzae in rice,encodes an LRR receptor kinase-like protein.Plant J.2004,37:517-527
207.Swiderski M R,Innes R W.The Arabidopsis PBS1 resistance gene encodes a member of a novel protein kinase subfamily.Plant J.2001,26:101 -112
208.Tai T H,Dahlbeck D.Clark E T.Gajiwala R Pasion R,Whalen M C.Stall R E.Staskawicz B J.Expression of the Bs2 pepper gene confers resistance to bacterial spot disease in tomato.Proc Natl Acad Sci USA.1999.96:14153-14158
209.Tameling W I,Vossen J H,Albrecht M.Lengauer T,Berden J A.Haring M A.Comelissen B J.Takken F L.Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation.Plant Physiol,2006,140:1233-1245
210.Takahashi H.Miller J.Nozaki Y.Sukamto,Takeda M.Shah J.Hase S,Ikegami M.Ehara Y.Dinesh-Kumar S P.RCY1.an Arahidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism. Plant J, 2002. 32:655-667
211. Takasaki T. Hatakeyama K, Suzuki G, Watanabe M, Isogai A. Hinata K. The S receptor kinase determines self-incompatibility in Brassica stigma. Nature, 2000. 403:913-916
212. Tang X, Frederick R D. Zhou J, Halterman D A, Jia Y, Martin G B. Initiation of plant disease resistance by physical interaction of AvrPto and Pto Kinase. Science. 1996, 274:2060-2063
213. Thomas C M, Jones D A, Parniske M, Harrison K, Balint-Kurti P J, Hatzixanthis K, Jones J D. Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequences that determine recognitional specificity in Cf-4 and Cf-9. Plant Cell 1997, 9:2209-2224
214. Thurow C. Schiermeyer A. Krawczyk S, Butterbrodt T, Nickolov K. Gatz C. Tobacco bZIP transcription factor TGA2.2 and related factor TGA2.1 have distinct roles in plant defense responses and plant development. Plant J, 2005, 44:100-113
215. Tor M, Brown D. Cooper A. Woods-Tor A, Sjolander K, Jones JDG, Holub E B. Arabidopsis downy mildew resistance gene RPP27 encodes a receptor-like protein similar to CLAVATA2 and tomato Cf-9. Plant Physiol. 2004, 135:1100-1112
216. Trotochaud A E. Jeong S, Clark S E. CLAVATA3. a multimeric ligand for the CLAVATA1 receptor-kinase. Science, 2000, 289:613-617
217. Uknes S. Dincher S. Friedrich L. Negrotto D. Williams S. Thompson-Taylor H. Potter S. Ward E. Ryals J. Regulation of pathogenesis-related Protein-1a gene expression in tobacco. Plant Cell. 1993. 5:159-169
218. Underwood W. Zhang SQ. He S Y. The Pseudomonas syringae type III effector tyrosine phosphatase HopAOl suppresses innate immunity in Arabidopsis thaliana. Plant J. 2007, 52:658-672
219. van der Biezen E A. Freddie C T. Kahn K. Parker J E. Jones JDG. Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components.Plant J,2002,29:439-451
220.Van Der Biezen E A,Jones JDG.Plant disease-resistance proteins and the gene-for-gene concept.Trends Biochem Sci,1998,23:454-456
221.van der Knaap E,Song W Y,Ruan D L,Sauter M,Ronald P C.Kende H.Expression of a gibberellin-induced leucine-rich repeat receptor-like protein kinase in deepwater rice and its interaction with kinase-associated protein phosphatase.Plant Physiol,1999,120:559-569
222.van der Vossen EAG,van der Voort J,Kanyuka K,Bendahmane A,Sandbrink H.Baulcombe D C,Bakker J,Stiekema W J,Klein-Lankhorst R M.Homologues of a single resistance-gene cluster in potato confer resistance to distinct pathogens:a virus and a nematode.Plant J,2000,23:567-576
223.Verica J A,He Z H.The cell wall-associated kinase(WAK) and WAK-like kinase gene family.Plant Physiol,2002,129:455-459
224.Walker J C,Zhang R.Relationship of a putative receptor protein-kinase from Maize to the S-Locus Glycoproteins of Brassica.Nature,1990,345:743-746
225.Wan J R,Zhang X C,Neece D,Ramonell K M,Clough S,Kim S Y.Stacey M G.Stacey G.A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis.Plant Cell,2008,20:471-481
226.Wang D.Weaver N D.Kesarwani M,Dong X N.Induction of protein secretory pathway is required for systemic acquired resistance.Science.2005.308:1036-1040
227.Wang G L,Song W Y.Ruan D L,Sideris S,Ronald P C.The cloned gene,Xa21.confers resistance to multiple Xanthomonas oryzae pv oryzae isolates in transgenic plants.Mol Plant-Microbe Interact,1996,9:850-855
228.Wang X L.Chory J.Brassinosteroids regulate dissociation of BKI1.a negative regulator of BRI1 signaling,from the plasma membrane.Science.2006.313:1118-1122
229.Wang Y S.Pi L Y.Chen X H,Chakrabarty P K.Jiang J.De Leon A L.Liu G Z.Li L C.Benny U.Oard J,Ronald P C,Song W Y.Rice XA21 binding protein 3 is a ubiquitin ligase required for full Xa21-mediated disease resistance. Plant Cell. 2006, 18:3635-3646
230. Wang Z X, Yano M, Yamanouchi U, Iwamoto M. Monna L, Hayasaka H, Katayose Y. Sasaki T. The Pib gene for rice blast resistance belongs to the nucleotide binding and leucine-rich repeat class of plant disease resistance genes. Plant J, 1999, 19:55-64
231. Wang Z Y, Seto H. Fujioka S, Yoshida S, Chory J. BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature, 2001, 410:380-383
232. Warren R F, Henk A, Mowery P, Holub E, Innes R W. A mutation within the leucine-rich repeat domain of the Arabidopsis disease resistance gene RPS5 partially suppresses multiple bacterial and downy mildew resistance genes. Plant Cell, 1998, 10:1439-1452
233. Weigel R R, Baeuscher C, Pfitzner AJP. Pfitzner U M. NIMIN-1, NIMIN-2 and NIMIN-3, members of a novel family of proteins from Arabidopsis that interact with NPR1/NIM1, a key regulator of systemic acquired resistance in plants. Plant Mol Biol. 2001.46:143-160
234. Weigel R R, Pfitzner U M, Gatz C. Interaction of NIMIN1 with NPR1 modulates PR gene expression in Arabidopsis. Plant Cell, 2005. 17:1279-1291
235. Westerink N, Brandwagt B F, de Wit P. Joosten M. Cladosporium fulvum circumvents the second functional resistance gene homologue at the Cf-4 locus (Hcr9-4E) by secretion of a stable avr4E isoform. Mol Microbiol. 2004, 54:533-545
236. Whitham S. Dinesh-Kumar S P, Choi D. Hehl R. Con- C. Baker B. The product of the tobacco mosaic virus resistance gene A': similarity to toll and the interleukin-1 receptor. Cell, 1994. 78:1101 -1115
237. Wildermuth M C. Dewdney J. Wu G, Ausubel F M. Isochorismate synthase is required to synthesize salicylic acid for plant defence. Nature. 2001. 414:562-565
238. Xiang T T. Zong N. Zou Y. Wu Y. Zhang J. Xing W M, Li Y. Tang X Y Zhu L H. Chai J J. Zhou J M. Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol. 2008. 18:74-80
239.Xiao S,Ellwood S,Calis O,Patrick E,Li T,Coleman M.Turner J G.Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8.Science.2001,291:118-120
240.Xing W,Zou Y,Liu Q,Liu J N,Luo X,Huang Q Q,Chen S,Zhu L H,Bi R C,Hao Q,Wu J W,Zhou J M,Chai J J.The structural basis for activation of plant immunity by bacterial effector protein AvrPto.Nature,2007,449:243-247
241.Xu W H,Wang Y S,Liu G Z,Chen X H.Tinjuangjun R Pi L Y,Song W Y.The autophosphorylated Ser686,Thr688,and Ser689 residues in the intracellular juxtamembrane domain of XA21 are implicated in stability control of rice receptor-like kinase.Plant J,2006,45:740-751
242.Yahiaoui N,Srichumpa P,Dudler R,Keller B.Genome analysis at different ploidy levels allows cloning of the powdery mildew resistance gene Pm3b from hexaploid wheat.Plant J,2004,37:528-538
243.Yamaguchi T,Yamada A,Hong N,Ogawa T,Ishii T.Shibuya N.Differences in the recognition of glucan elicitor signals between rice and soybean:beta-glucan fragments from the rice blast disease fungus Pyricularia oryzae that elicit phytoalexin biosynthesis in suspension-cultured rice cells.Plant Cell.2000.12:817-826
244.Yang B,Sugio A,White F F.Os8N3 is a host disease-susceptibility gene for bacterial blight office.Proc Natl Acad Sci USA.2006.10310503-10508
245.Yin Y H,Wang Z Y,Mora-Garcia S.Li J M,Yoshida S,Asami T.Chory J.BES1accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation.Cell.2002.109:181 - 191
246.Yoshimura S,Yamanouchi U,Katayose Y.Toki S.Wang Z X.Kono I.Kurata N.Yano M.Iwata N,Sasaki T.Expression of Xa1,a bacterial blight-resistance gene in rice.is induced by bacterial inoculation.Proc Nail Acad Sci USA,1998.95:1663-1668
247.Yuan J.He SY.The Pseudomonas syringae hrp regulation and secretion system controls the production and secretion of multiple extracellular proteins.J Bacteriol.1996.178:6399-6402
248.Yuan Q P,Shu O Y,Wang A H,Zhu W,Maiti R,Lin H N,Hamilton J,Haas B.Sultana R,Cheung F.Wortman J,Buell C R.The institute for genomic research Osal rice genome annotation database.Plant Physiology,2005,138:17-26
249.Zhang J,Shao F,Cui H,Chen L J,Li H T,Zou Y,Long C Z,Lan L K Chai J J,Chen S.Tang X Y,Zhou J M.A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-Induced immunity in plants.Cell Host Microbe,2007,1:175-185
250.Zhang X C,Gassmann W.Alternative splicing and mRNA levels of the disease resistance gene RPS4 are induced during defense responses.Plant Physiol,2007.145:1577-87
251.Zhao Y F,Thilmony R,Bender C L,Schaller A,He S Y,Howe G A.Virulence systems of Pseudomonas syringae pv.tomato promote bacterial speck disease in tomato by targeting the jasmonate signaling pathway.Plant J,2003,36:485-499
252.Zhou B,Qu S H,Liu G F.Dolan M,Sakai H,Lu G D,Bellizzi M.Wang G L.The eight amino-acid differences within three leucine-rich repeats between Pi2 and Piz-t resistance proteins determine the resistance specificity to Magnaporthe grisea.Mol Plant-Microbe Interact,2006.19:1216-1228
253.Zhou F S,Kurth J C.Wei F S.Elliott C,Vale G,Yahiaoui N,Keller B,Somerville S,Wise R,Schulze-Lefert P.Cell-autonomous expression of barley Mla1 confers race-specific resistance to the powdery mildew fungus via a Rarl-independent signaling pathway.Plant Cell,2001,13:337-350
254.Zhu W G.Yang B,Chittoor J M.Johnson L B,White F F.AvrXa10 contains an acidic transcriptional activation domain in the functionally conserved C terminus.Mol Plant-Microbe Interact.1998.11:824-832
255.Zimmermann P,Hirsch-Hoffmann M.Hennig L,Gruissem W.Arabidopsis microarray database and analysis toolbox.Plant Physiol,2004.136:2621-2632
256.Zipfel C.Felix G.Plants and animals:a different taste for microbes? Curt Opin Plant Biol.2005.8:353-360
257.Zipfel C,Kunze G.Chinchilla D,Caniard A.Jones JDG,Boller T,Felix G.Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell, 2006, 125:749-760
258. Zipfel C, Robatzek S. Navarro L, Oakeley E J, Jones JDG, Felix G, Boiler T. Bacterial disease resistance in Arabidopsis through flagellin perception. Nature, 2004. 428:764-767
259. Zwiesler-Vollick J, Plovanich-Jones A E, Nomura K, Bandyopadhyay S, Joardar V, Kunkel B N. He S Y. Identification of novel hrp-regulated genes through functional genomic analysis of the Pseudomonas syringae pv. tomato DC3000 genome. Mol Microbiol, 2002, 45:1207-1218