病毒靶向人Ⅰ型干扰素受体1的负调控机制
|
摘要
人Ⅰ型干扰素(type Ⅰ interferon,IFN-Ⅰ)的诱生和应答在机体抗病毒固有免疫中发挥重要作用。但病毒多可逃逸宿主此类抗病毒免疫,导致感染和致病。Ⅰ型干扰素受体(interferon alpha receptor,IFNAR)是识别及结合IFN-I的一种跨细胞膜蛋白受体,其IFNAR1亚型在干扰素发挥抗病毒效应的启动阶段发挥关键作用;本文从IFNAR1蛋白质的表达、降解及其功能等方面,概述病毒以IFNAR1为靶点负调控IFN-I的抗病毒机制,以期为该领域基础研究和临床抗病毒策略提供有益的参考依据。
The human type I interferon( IFN-I) induction and response are the most important events in antiviral innate immune responses of hosts. However,viruses could utilize diverse mechanisms to escape from the host antiviral immunity, favoring viruses to cause diseases. Interferon alpha receptor 1( IFNAR1) is the most critical transmembrane protein that initiates IFN-I-induced signaling pathways and mediates the anti-viral stage of type I IFNs. This article summarized negative regulation of IFNAR1 by viruses involved in the protein expression,degradation and function of IFNAR1,in order to provide some references for basic research and developing novel antiviral strategies in this field.
The human type I interferon( IFN-I) induction and response are the most important events in antiviral innate immune responses of hosts. However,viruses could utilize diverse mechanisms to escape from the host antiviral immunity, favoring viruses to cause diseases. Interferon alpha receptor 1( IFNAR1) is the most critical transmembrane protein that initiates IFN-I-induced signaling pathways and mediates the anti-viral stage of type I IFNs. This article summarized negative regulation of IFNAR1 by viruses involved in the protein expression,degradation and function of IFNAR1,in order to provide some references for basic research and developing novel antiviral strategies in this field.
引文
[1] George-PM,Badiger R,Alazawi W,et al. Pharmacology and therapeutic potential of interferons[J]. Pharmacol Ther,2012,135(1):44-53
[2] Lei X, Xiao X, Wang J. Innate immunity evasion by enteroviruses:insights into virus-host interaction[J]. Viruses,2016,8(1). pii:E22
[3] Bowie AG,Unterholzner L. Viral evasion and subversion of pattern-recognition receptor signalling[J]. Nat Rev Immunol,2008,8(12):911-922
[4] Ling LE,Zafari M,Reardon D,et al. Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 k D membrane protein[J]. J Interferon Cytokine Res,1995,15(1):55-61
[5] Constantinescu SN,Croze E,Murti A,et al. Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex[J]. Proc Natl Acad Sci U S A,1995,92(23):10487-10491
[6] Subramaniam PS,Johnson HM. The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence[J]. FEBS Lett,2004,578(3):207-210
[7] Chow KT,Gale M Jr. SnapShot:Interferon Signaling[J]. Cell,2015,163(7):1808-1808.e1
[8] Huangfu WC,Qian J,Liu C,et al. Inflammatory signaling compromises cell responses to interferon alpha[J]. Oncogene,2012,31(2):161-172
[9] Fuchs SY. Ubiquitination-mediated regulation of interferon responses[J]. Growth Factors,2012,30(3):141-148
[10] Zheng H,Qian J,Baker DP,et al. Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor[J]. J Biol Chem,2011,286(41):35733-35741
[11] Zheng H, Qian J, Varghese B, et al. Ligand-stimulated downregulation of the alpha interferon receptor:role of protein kinase D2[J]. Mol Cell Biol,2011,31(4):710-720
[12] Marijanovic Z,Ragimbeau J,Kumar KG,et al. TYK2 activity promotes ligand-induced IFNAR1 proteolysis[J]. Biochem J,2006,397(1):31-38
[13] Kumar KG,Tang W,Ravindranath AK,et al. SCF(HOS)ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor[J]. EMBO J,2003,22(20):5480-5490
[14] Kumar KG, Barriere H, Carbone CJ, et al. Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis[J]. J Cell Biol,2007,179(5):935-950
[15] Kumar KG,Varghese B,Banerjee A,et al. Basal ubiquitinindependent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif[J]. J Biol Chem,2008,283(27):18566-18572
[16] Carbone CJ,Zheng H,Bhattacharya S,et al. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies[J]. Proc Natl Acad Sci U S A,2012,109(47):19226-19231
[17] Zheng H,Gupta V,Patterson-Fortin J,et al. A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses[J]. Cell Rep,2013,5(1):180-193
[18] Malakhova OA,Kim KI,Luo JK,et al. UBP43 is a novel regulator of interferon signaling independent of its ISG15isopeptidase activity[J]. EMBO J,2006,25(11):2358-2367
[19] Arimoto KI,L9chte S,Stoner SA,et al. STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling[J]. Nat Struct Mol Biol,2017,24(3):279-289
[20] Ragimbeau J,Dondi E,Alcover A,et al. The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression[J]. EMBO J,2003,22(3):537-547
[21] Araya RE, Goldszmid RS. IFNAR1 Degradation:A New Mechanism for Tumor Immune Evasion?[J]. Cancer Cell,2017,31(2):161-163
[22] Katlinski KV,Gui J,Katlinskaya YV,et al. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment[J]. Cancer Cell,2017,31(2):194-207
[23] Friborg J,Ross-Macdonald P,Cao J,et al. Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes[J].PLoS One,2015,10(3):e0121734
[24] Chandra PK,Gunduz F,Hazari S,et al. Impaired expression of type I and type II interferon receptors in HCV-associated chronic liver disease and liver cirrhosis[J]. PLoS One, 2014, 9(9):e108616
[25] Han T,Wan Y,Wang J,et al. Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway[J]. J Immunol,2015,194(6):2757-2768
[26] He CL,Liu M,Tan ZX,et al. Hepatitis C virus core proteininduced miR-93-5p up-regulation inhibits interferon signaling pathway by targeting IFNAR1[J]. World J Gastroenterol,2018,24(2):226-236
[27] Jarret A,Mc Farland AP,Horner SM,et al. Hepatitis-C-virusinduced microRNAs dampen interferon-mediated antiviral signaling[J]. Nat Med,2016,22(12):1475-1481
[28] Zhang Y,Yang L,Wang H,et al. Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-αreceptor[J]. Biochem Biophys Res Commun,2016,478(3):1436-1441
[29] Lubick KJ, Robertson SJ, Mc Nally KL, et al. Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression[J]. Cell Host Microbe,2015,18(1):61-74
[30] Lu J,Yi L,Zhao J,et al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1[J]. J Virol,2012,86(7):3767-3776
[31] Morrison JM,Racaniello VR. Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells[J]. J Virol,2009,83(9):4412-4422
[32] Sen A,Sharma A,Greenberg HB. Rotavirus degrades multiple interferon(IFN)type receptors to inhibit IFN signaling and protects against mortality from endotoxin in suckling mice[J]. J Virol,2017.pii:JVl. e01394-17
[33] Kurt R,Chandra PK,Aboulnasr F,et al. Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture[J]. PLoS One,2015,10(5):e0125962
[34] Zhang Q,Gong R,Qu J,et al. Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway[J]. J Virol,2012,86(3):1544-1554
[35] Bhattacharya S,Qian J,Tzimas C,et al. Role of p38 protein kinase in the ligand-independent ubiquitination and downregulation of the IFNAR1 chain of type I interferon receptor[J]. J Biol Chem,2011,286(25):22069-22076
[36] Qian J,Zheng H,Huangfu WC,et al. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1[J]. PLoS Pathog, 2011, 7(6):e1002065
[37] Liu J,HuangFu WC,Kumar KG,et al. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylationdependent degradation of the type I interferon receptor[J]. Cell Host Microbe,2009,5(1):72-83
[38] Liu J,Carvalho LP,Bhattacharya S,et al. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling[J]. Mol Cell Biol,2009,29(24):6401-6412
[39] Xia C,Vijayan M,Pritzl CJ,et al. Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon(IFN)Responses by Inducing Degradation of Type I IFN Receptor 1[J]. J Virol,2015,90(5):2403-2417
[40] Teijaro JR,Studer S,Leaf N,et al. S1PR1-mediated IFNAR1degradation modulates plasmacytoid dendritic cell interferon-αautoamplification[J]. Proc Natl Acad Sci U S A,2016,113(5):1351-1356
[41] Cho IR,Oh M,Koh SS,et al. Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor[J]. Int J Mol Med,2012,29(4):581-586
[42] Chen J,Xu W,Chen Y,et al. Matrix metalloproteinase 9facilitates hepatitis B virus replication through binding with type i interferon(IFN)receptor 1 to repress IFN/JAK/STAT signaling[J]. J Virol,2017,91(8). pii:e01824-16
[43] Shah KM,Stewart SE,Wei W,et al. The EBV-encoded latent membrane proteins,LMP2A and LMP2B,limit the actions of interferon by targeting interferon receptors for degradation[J].Oncogene,2009,28(44):3903-3914
[44] Datta S,Hazari S,Chandra PK,et al. Mechanism of HCV's resistance to IFN-αin cell culture involves expression of functional IFN-αreceptor 1[J]. Virol J,2011,8:351
[45] Bisson SA,Page AL,Ganem D. A Kaposi’s sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits,Jak and STAT proteins,and blocks interferon-mediated signal transduction[J]. J Virol,2009,83(10):5056-5066
[46] Yokota S,Saito H,Kubota T,et al. Measles virus suppresses interferon-alpha signaling pathway:suppression of Jak1phosphorylation and association of viral accessory proteins,C and V,with interferon-alpha receptor complex[J]. Virology,2003,306(1):135-146
[47] Symons JA,AlcamíA,Smith GL. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity[J]. Cell,1995,81(4):551-560
[48] Liu Y,Zhang Z,Zhao X,et al. Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression[J]. Viral Immunol,2014,27(6):267-276
[49] Wang C,Sun M,Yuan X,et al. Enterovirus 71 suppresses interferon responses by blocking Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling through inducing karyopherin-α1 degradation[J]. J Biol Chem,2017,292(24):10262-10274
[2] Lei X, Xiao X, Wang J. Innate immunity evasion by enteroviruses:insights into virus-host interaction[J]. Viruses,2016,8(1). pii:E22
[3] Bowie AG,Unterholzner L. Viral evasion and subversion of pattern-recognition receptor signalling[J]. Nat Rev Immunol,2008,8(12):911-922
[4] Ling LE,Zafari M,Reardon D,et al. Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 k D membrane protein[J]. J Interferon Cytokine Res,1995,15(1):55-61
[5] Constantinescu SN,Croze E,Murti A,et al. Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex[J]. Proc Natl Acad Sci U S A,1995,92(23):10487-10491
[6] Subramaniam PS,Johnson HM. The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence[J]. FEBS Lett,2004,578(3):207-210
[7] Chow KT,Gale M Jr. SnapShot:Interferon Signaling[J]. Cell,2015,163(7):1808-1808.e1
[8] Huangfu WC,Qian J,Liu C,et al. Inflammatory signaling compromises cell responses to interferon alpha[J]. Oncogene,2012,31(2):161-172
[9] Fuchs SY. Ubiquitination-mediated regulation of interferon responses[J]. Growth Factors,2012,30(3):141-148
[10] Zheng H,Qian J,Baker DP,et al. Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor[J]. J Biol Chem,2011,286(41):35733-35741
[11] Zheng H, Qian J, Varghese B, et al. Ligand-stimulated downregulation of the alpha interferon receptor:role of protein kinase D2[J]. Mol Cell Biol,2011,31(4):710-720
[12] Marijanovic Z,Ragimbeau J,Kumar KG,et al. TYK2 activity promotes ligand-induced IFNAR1 proteolysis[J]. Biochem J,2006,397(1):31-38
[13] Kumar KG,Tang W,Ravindranath AK,et al. SCF(HOS)ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor[J]. EMBO J,2003,22(20):5480-5490
[14] Kumar KG, Barriere H, Carbone CJ, et al. Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis[J]. J Cell Biol,2007,179(5):935-950
[15] Kumar KG,Varghese B,Banerjee A,et al. Basal ubiquitinindependent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif[J]. J Biol Chem,2008,283(27):18566-18572
[16] Carbone CJ,Zheng H,Bhattacharya S,et al. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies[J]. Proc Natl Acad Sci U S A,2012,109(47):19226-19231
[17] Zheng H,Gupta V,Patterson-Fortin J,et al. A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses[J]. Cell Rep,2013,5(1):180-193
[18] Malakhova OA,Kim KI,Luo JK,et al. UBP43 is a novel regulator of interferon signaling independent of its ISG15isopeptidase activity[J]. EMBO J,2006,25(11):2358-2367
[19] Arimoto KI,L9chte S,Stoner SA,et al. STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling[J]. Nat Struct Mol Biol,2017,24(3):279-289
[20] Ragimbeau J,Dondi E,Alcover A,et al. The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression[J]. EMBO J,2003,22(3):537-547
[21] Araya RE, Goldszmid RS. IFNAR1 Degradation:A New Mechanism for Tumor Immune Evasion?[J]. Cancer Cell,2017,31(2):161-163
[22] Katlinski KV,Gui J,Katlinskaya YV,et al. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment[J]. Cancer Cell,2017,31(2):194-207
[23] Friborg J,Ross-Macdonald P,Cao J,et al. Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes[J].PLoS One,2015,10(3):e0121734
[24] Chandra PK,Gunduz F,Hazari S,et al. Impaired expression of type I and type II interferon receptors in HCV-associated chronic liver disease and liver cirrhosis[J]. PLoS One, 2014, 9(9):e108616
[25] Han T,Wan Y,Wang J,et al. Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway[J]. J Immunol,2015,194(6):2757-2768
[26] He CL,Liu M,Tan ZX,et al. Hepatitis C virus core proteininduced miR-93-5p up-regulation inhibits interferon signaling pathway by targeting IFNAR1[J]. World J Gastroenterol,2018,24(2):226-236
[27] Jarret A,Mc Farland AP,Horner SM,et al. Hepatitis-C-virusinduced microRNAs dampen interferon-mediated antiviral signaling[J]. Nat Med,2016,22(12):1475-1481
[28] Zhang Y,Yang L,Wang H,et al. Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-αreceptor[J]. Biochem Biophys Res Commun,2016,478(3):1436-1441
[29] Lubick KJ, Robertson SJ, Mc Nally KL, et al. Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression[J]. Cell Host Microbe,2015,18(1):61-74
[30] Lu J,Yi L,Zhao J,et al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1[J]. J Virol,2012,86(7):3767-3776
[31] Morrison JM,Racaniello VR. Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells[J]. J Virol,2009,83(9):4412-4422
[32] Sen A,Sharma A,Greenberg HB. Rotavirus degrades multiple interferon(IFN)type receptors to inhibit IFN signaling and protects against mortality from endotoxin in suckling mice[J]. J Virol,2017.pii:JVl. e01394-17
[33] Kurt R,Chandra PK,Aboulnasr F,et al. Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture[J]. PLoS One,2015,10(5):e0125962
[34] Zhang Q,Gong R,Qu J,et al. Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway[J]. J Virol,2012,86(3):1544-1554
[35] Bhattacharya S,Qian J,Tzimas C,et al. Role of p38 protein kinase in the ligand-independent ubiquitination and downregulation of the IFNAR1 chain of type I interferon receptor[J]. J Biol Chem,2011,286(25):22069-22076
[36] Qian J,Zheng H,Huangfu WC,et al. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1[J]. PLoS Pathog, 2011, 7(6):e1002065
[37] Liu J,HuangFu WC,Kumar KG,et al. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylationdependent degradation of the type I interferon receptor[J]. Cell Host Microbe,2009,5(1):72-83
[38] Liu J,Carvalho LP,Bhattacharya S,et al. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling[J]. Mol Cell Biol,2009,29(24):6401-6412
[39] Xia C,Vijayan M,Pritzl CJ,et al. Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon(IFN)Responses by Inducing Degradation of Type I IFN Receptor 1[J]. J Virol,2015,90(5):2403-2417
[40] Teijaro JR,Studer S,Leaf N,et al. S1PR1-mediated IFNAR1degradation modulates plasmacytoid dendritic cell interferon-αautoamplification[J]. Proc Natl Acad Sci U S A,2016,113(5):1351-1356
[41] Cho IR,Oh M,Koh SS,et al. Hepatitis B virus X protein inhibits extracellular IFN-α-mediated signal transduction by downregulation of type I IFN receptor[J]. Int J Mol Med,2012,29(4):581-586
[42] Chen J,Xu W,Chen Y,et al. Matrix metalloproteinase 9facilitates hepatitis B virus replication through binding with type i interferon(IFN)receptor 1 to repress IFN/JAK/STAT signaling[J]. J Virol,2017,91(8). pii:e01824-16
[43] Shah KM,Stewart SE,Wei W,et al. The EBV-encoded latent membrane proteins,LMP2A and LMP2B,limit the actions of interferon by targeting interferon receptors for degradation[J].Oncogene,2009,28(44):3903-3914
[44] Datta S,Hazari S,Chandra PK,et al. Mechanism of HCV's resistance to IFN-αin cell culture involves expression of functional IFN-αreceptor 1[J]. Virol J,2011,8:351
[45] Bisson SA,Page AL,Ganem D. A Kaposi’s sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits,Jak and STAT proteins,and blocks interferon-mediated signal transduction[J]. J Virol,2009,83(10):5056-5066
[46] Yokota S,Saito H,Kubota T,et al. Measles virus suppresses interferon-alpha signaling pathway:suppression of Jak1phosphorylation and association of viral accessory proteins,C and V,with interferon-alpha receptor complex[J]. Virology,2003,306(1):135-146
[47] Symons JA,AlcamíA,Smith GL. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity[J]. Cell,1995,81(4):551-560
[48] Liu Y,Zhang Z,Zhao X,et al. Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression[J]. Viral Immunol,2014,27(6):267-276
[49] Wang C,Sun M,Yuan X,et al. Enterovirus 71 suppresses interferon responses by blocking Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling through inducing karyopherin-α1 degradation[J]. J Biol Chem,2017,292(24):10262-10274