呼吸窘迫综合征患儿炎性因子水平变化及相关性分析
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摘要
目的探讨呼吸窘迫综合征(NRDS)患儿炎性因子水平变化情况及NRDS病情与炎性因子水平的相关性。方法选择2013年2月至2015年12月在开封市儿童医院就诊的NRDS患儿46例。选择同时期同科室的正常新生儿46例为对照组。根据胸片结果对NRDS病情进行分级,Ⅰ、Ⅱ级为轻度组31例,Ⅲ、Ⅳ级为重度组15例。比较两组炎性因子水平。结果 NRDS组患儿血清白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)明显高于对照组(t=12.774,8.373,均P=0.000),两组肿瘤坏死因子-α(TNF-α)差异无统计学意义(t=1.527,P=0.130)。NRDS病情与IL-1β和IL-6呈正相关(r=0.47、0.42,P<0.05)。结论 NRDS患儿血清IL-1β,IL-6明显升高,与NRDS病情严重程度关系密切,联合检测IL-1β,IL-6对NRDS病情评估具有重要意义。
Objective To investigate the levels of inflammatory cytokines in children with respiratory distress syndrome(NRDS).Methods Forty-six children with NRDS were enrolled in our hospital from February 2013 to Decembder 2015.Forty-six normal newborn infants of the same period were selected as control group.The severity of NRDS was graded according to the result of chest radiography,with 31 cases in the mild group of Ⅰ and Ⅱ,15 cases of severe groud Ⅲ and Ⅳ.Results The levels of serum IL-1β and IL-6 in the NRDS group were significantly higher than those in the control group(t=12.774,8.373,all P=0.000).There was no significant difference between the two groups of the TNF-α(t=1.527,P=0.130).NRDS disease and IL-1β and IL-6 were positively correlated(r=0.47、0.42,P<0.05).Conclusion The levels of IL-1β and IL-6 in serum of children with NRDS are significantly higher than those of NRDS.The detection of IL-1β and IL-6 in NRDS have great significance.
Objective To investigate the levels of inflammatory cytokines in children with respiratory distress syndrome(NRDS).Methods Forty-six children with NRDS were enrolled in our hospital from February 2013 to Decembder 2015.Forty-six normal newborn infants of the same period were selected as control group.The severity of NRDS was graded according to the result of chest radiography,with 31 cases in the mild group of Ⅰ and Ⅱ,15 cases of severe groud Ⅲ and Ⅳ.Results The levels of serum IL-1β and IL-6 in the NRDS group were significantly higher than those in the control group(t=12.774,8.373,all P=0.000).There was no significant difference between the two groups of the TNF-α(t=1.527,P=0.130).NRDS disease and IL-1β and IL-6 were positively correlated(r=0.47、0.42,P<0.05).Conclusion The levels of IL-1β and IL-6 in serum of children with NRDS are significantly higher than those of NRDS.The detection of IL-1β and IL-6 in NRDS have great significance.
引文
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[2] PEI L,WEN GF,SONG WL,et al.Risk factors for the development of acute respiratory distress syndrome in children with measles[J].CJCP,2015,17(3):245-248.
[3] DE AZEVEDO-QUINTANILHA IG,VIEIRA-DE-ABREU A,FERREIRA AC,et al.Integrin αDβ2(CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome(MA-ARDS)[J].Malar J,2016,15(1):393.
[4] GUO C,GOODWIN A,BUIE JNJ,et al.A stromal cell–derived factor 1α analogue improves endothelial cell function in lipopolysaccharide-induced acute respiratory distress syndrome[J].Mol Med,2016,22:115-123.
[5] GONZALES J,LUCAS R,VERIN A.The acute respiratory distress syndrome:mechanisms and perspective therapeutic approaches[J].Austin J Vasc Med,2015,2(1):1009.
[6] PRINCE LR,MAXWELL NC,GILL SK,et al.Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease[J].PLoS One,2014,9(8):e103059.DOI:10.1371/journal.pone.0103059.
[7] ZHU WW,KONG GQ,MA MM,et al.Short communication:camel milk ameliorates inflammatory responses and oxidative stress and downregulates mitogen-activated protein kinase signaling pathways in lipopolysaccharide-induced acute respiratory distress syndrome in rats[J].J Dairy Sc,2016,99(1):53-56.
[8] LIM JK,LEE JH,CHEIFETZ MI.Special considerations for the management of pediatric acute respiratory distress syndrome[J].Expert Rev Respir Med,2016,10(10):1133-1145.