复方丁香挥发油的提取和包合工艺研究
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摘要
目的研究复方丁香挥发油的提取和包合工艺。方法以提取的挥发油体积为评价指标,采用正交设计优选水蒸气蒸馏法提取丁香、砂仁和胡椒三味中药中的挥发油的最优条件;以包合率为评价指标,采用单因素实验和正交实验,优选最佳的包合工艺条件。结果复方丁香挥发油的最佳提取工艺条件为:药材加8倍水量,浸泡2.5h,加热蒸馏提取6h,挥发油平均含量为4.74%;复方丁香挥发油包合物的最佳条件为:挥发油与β-CD比例为1∶8,包合温度为40℃,包合时间为4h,洗涤溶剂为石油醚,干燥温度为40℃,挥发油平均包合率为81.5%。结论优选的提取工艺和包合工艺条件科学、合理、可行。
Objective To study the extraction and inclusion of volatile oil from compound clove. Methods Using the extracted volatile oil volume as the evaluation index,the optimum conditions for extraction of volatile oil from traditional Chinese medicine of clove,parsley and pepper were optimized by orthogonal design. Taking the inclusion ratio as the evaluation index,a single factor experiment and orthogonal experiment were carried out to optimize the optimal conditions of the inclusion process. Results The optimum conditions for extraction of compound clove volatile oil were as follows :8 times water was added to medicinal materials,the soaking time was 2.5 hours,the heating distillation extraction time was 6 hours,and the average volatile oil content was 4.74 %. The optimum conditions for compound clove volatile oil inclusions were as follows :The ratio of volatile oil to β-CD was 1 ∶ 8,the inclusion temperature was 40℃,the inclusion time was 4 hours,the washing solvent was petroleum ether,the drying temperature was 40℃,and the average inclusion rate of volatile oil was 81.5 %. Conclusion Optimized extraction process and Inclusion process were scientific,reasonable and feasible.
Objective To study the extraction and inclusion of volatile oil from compound clove. Methods Using the extracted volatile oil volume as the evaluation index,the optimum conditions for extraction of volatile oil from traditional Chinese medicine of clove,parsley and pepper were optimized by orthogonal design. Taking the inclusion ratio as the evaluation index,a single factor experiment and orthogonal experiment were carried out to optimize the optimal conditions of the inclusion process. Results The optimum conditions for extraction of compound clove volatile oil were as follows :8 times water was added to medicinal materials,the soaking time was 2.5 hours,the heating distillation extraction time was 6 hours,and the average volatile oil content was 4.74 %. The optimum conditions for compound clove volatile oil inclusions were as follows :The ratio of volatile oil to β-CD was 1 ∶ 8,the inclusion temperature was 40℃,the inclusion time was 4 hours,the washing solvent was petroleum ether,the drying temperature was 40℃,and the average inclusion rate of volatile oil was 81.5 %. Conclusion Optimized extraction process and Inclusion process were scientific,reasonable and feasible.
引文
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[2]尹卫平,赵天增,等.丁香属河南小叶丁香挥发油成分的研究[J].中草药,1998(4):225-226.
[3]王红武,张明发,沈雅琴,等.砂仁对消化系统药理作用的实验研究[J].中国中医药科技,1997,4(5):284.
[4]胡玉兰,张忠义,林敬明.中药砂仁的化学成分和药理活性研究进展[J].中药材,2005,28(1):72.
[5]ChP(中国药典).2015,VolⅠ(一部):243.
[6]温悦.挥发油提取方法研究概况[J].中国中医药科技,2010,19(12):375.
[7]杨小艳,毛羽,等.白胡椒挥发油的提取工艺研究[N].西南民族大学学报:自然科学版,2009,35(3):556-558
[8]方学智,姚小华,王开良,等.不同制油方法对油茶籽油品质的影响[J].中国油脂,2009,34(1):23-25.
[9]耿晶娟,舒奕,陶莎,薛文通.不同方法提取火麻籽油的品质分析[J].中国油脂,2015,40(5):46-48.
[10]张玲,付佳,高军刚,等.香樟籽油的超声波辅助提取工艺研究[J].安徽农业科学,2010,38(1):352-353.
[11]吴忠,等.超临界CO2流体萃取海南砂有效成分的研究[J].中药材,2000,23(3):157.
[12]韩春然,张静,李煜.超声波法制备丁香精油-β-环糊精微胶囊[J].食品科学,2013,34(22):97-100.
[13]彭颖.肉桂精油的提取及其微胶囊化的研究[D].天津:天津商业大学,2012:1-10.
[14]陈琳皓,单杨,李高阳,等.复凝聚法制作甜橙香精微胶囊工艺研究[J].食品与机械,2016,32(3):198-202.
[15]刘光宪,周巾英,祝水兰,等.沙棘籽油微胶囊的制备及其性质研究[J].食品与机械,2017,33(8):194-197.
[16]袁超,祁鲲,朱新亮,等.茉莉精油/羟丙基-β-环糊精包合物的制备及表征[J].中国粮油学报,2017,32(10):85-89.
[17]孙芸,刘丛,杜为军,等.中药B-环糊精包合物的制备工艺及其应用研究进展[J].新疆师范大学学报,2008,27(4):1109.
[18]ChP(中国药典).2015,VolⅣ(四部):203-204.