血液灌流联合抗蛇毒血清对蛇咬伤所致急性重症患者的疗效
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摘要
目的探讨血液灌流(HP)联合抗蛇毒血清治疗蛇咬伤所致急性重症患者的效果。方法选择2017年10月～2018年11月我院收治的蛇咬伤所致急性重症患者70例为研究对象,按治疗的不同分为对照组和研究组各35例。对照组应用抗蛇毒血清+常规治疗,研究组在对照组的基础上加用血液灌流治疗。观察两组患者的治疗效果、肝肾功能以及凝血功能情况。结果研究组的治疗总有效率(88.57%)高于对照组(68.57%),总胆红素(TB)、尿素氮(BUN)均低于对照组,血浆凝血酶原时间(PT)、凝血酶时间(TT)均短于对照组,组间差异具有统计学意义(P<0.05)。结论血液灌流联合抗蛇毒血清治疗蛇咬伤所致急性重症患者的效果显著,能够提高治愈率,对肝、肾功能具有一定的积极作用。
Objective To investigate the effect of hemoperfusion combined with antivenom in treating patients with acute severe snake bite. Methods From October 2017 to November 2018,70 cases of severe acute snakebite patients admitted to our hospital were studied,and 35 cases were divided into control group and research group according to different treatment.The control group received antivenom+routine treatment,and the research group received hemoperfusion on the basis of the control group.The therapeutic effect,liver and kidney function and coagulation function of the two groups were observed. Results The total effective rate of the study group was higher(88.57%) than the control group(68.57%),the total bilirubin(TB),urea nitrogen(BUN) were lower than the control group,the plasma prothrombin time(PT),thrombin time(TT) were shorter than the control group,the difference between groups was statistically significant(P<0.05). Conclusion Hemoperfusion combined with antivenin serum is effective in treating acute patients with severe snake bite.
Objective To investigate the effect of hemoperfusion combined with antivenom in treating patients with acute severe snake bite. Methods From October 2017 to November 2018,70 cases of severe acute snakebite patients admitted to our hospital were studied,and 35 cases were divided into control group and research group according to different treatment.The control group received antivenom+routine treatment,and the research group received hemoperfusion on the basis of the control group.The therapeutic effect,liver and kidney function and coagulation function of the two groups were observed. Results The total effective rate of the study group was higher(88.57%) than the control group(68.57%),the total bilirubin(TB),urea nitrogen(BUN) were lower than the control group,the plasma prothrombin time(PT),thrombin time(TT) were shorter than the control group,the difference between groups was statistically significant(P<0.05). Conclusion Hemoperfusion combined with antivenin serum is effective in treating acute patients with severe snake bite.
引文
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[9] 杜洁,谢虹.注射用抗蛇毒血清分段稀释滴注对蛇咬伤患者的解毒疗效分析与临床护理[J].抗感染药学,2016,13(2):325.
[2] 贺东坡,谢智慧,喻安永,等.高压氧辅助抗蛇毒血清治疗对五步蛇毒中毒大鼠肾保护作用研究[J].重庆医学,2018,47(14):1862-1865,1869.
[3] 崔艳.综合性治疗毒蛇咬伤的临床疗效分析[J].世界最新医学信息文摘,2018,18(30):80,85.
[4] 赵燕,戴维.持续性床旁血液滤过联合灌流在毒蛇咬伤救治中的意义[J].陕西医学杂志,2017,46(12):1712-1713.
[5] 杨光喜.毒蛇咬伤468例的临床救治疗效分析[J].中国社区医师,2017,33(16):55,57.
[6] 钟桂年,罗朝汉,吴登锋,等.综合性治疗毒蛇咬伤的临床疗效分析[J].湖北科技学院学报(医学版),2017,31(1):33-35.
[7] 李培玲,周璇,熊飞霞.重症蛇咬伤的持续缓慢低效血液透析串联血液灌流治疗及护理体会[J].长江大学学报(自科版),2016,13(18):68-69,83.
[8] 杜洁.分段稀释滴注法注射抗蛇毒血清的临床效果观察[J].中国医院用药评价与分析,2016,16(1):80.
[9] 杜洁,谢虹.注射用抗蛇毒血清分段稀释滴注对蛇咬伤患者的解毒疗效分析与临床护理[J].抗感染药学,2016,13(2):325.