膳食中的主要成分对肠道微生物组成及代谢影响的研究进展
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摘要
随着对肠道微生物结构和功能的不断挖掘,研究发现肠道微生物参与人体与膳食相关的多项生理过程,膳食在调节人体肠道微生物的组成和代谢活动中有重要作用。膳食营养中含有肠道菌群代谢所需的底物,以多种途径影响肠道菌群的组成和功能。本文对近几年来国内外关于膳食主成分对肠道菌群组成及代谢影响的研究进行综述,以肠道菌群为靶点,通过调整人类的食物多样性来改善宿主的代谢能力和健康,旨在为肠道菌群的研究及其饮食调控提供参考。
With the continuous excavation of intestinal microbial structure and function,studies found that intestinal microbes participate in many physiological processes related to human diet,and diet plays an important role in regulating the composition and metabolic activities of human intestinal microbes. Dietary nutrients contain the substrate required for metabolism of the intestinal flora,affecting the composition and function of the intestinal flora in some ways. In this paper,effects of dietary components on the composition and metabolism of intestinal flora in recent years are reviewed. Targets were to improve the metabolism and health of the host by targeting the intestinal flora and regulating human food diversity.The purpose is to provide some ideas and references for the study of intestinal flora and its dietary regulation.
With the continuous excavation of intestinal microbial structure and function,studies found that intestinal microbes participate in many physiological processes related to human diet,and diet plays an important role in regulating the composition and metabolic activities of human intestinal microbes. Dietary nutrients contain the substrate required for metabolism of the intestinal flora,affecting the composition and function of the intestinal flora in some ways. In this paper,effects of dietary components on the composition and metabolism of intestinal flora in recent years are reviewed. Targets were to improve the metabolism and health of the host by targeting the intestinal flora and regulating human food diversity.The purpose is to provide some ideas and references for the study of intestinal flora and its dietary regulation.
引文
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[5]Schroeder B O,Bckhed F.Signals from the gut microbiota to distant organs in physiology and disease[J]. Nature Medicine,2016,22(10):1079.
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[27]Lecomte V,Kaakoush NO,Maloney CA,et al.Changes in gut microbiota in rats fed a high fat diet correlate with obesityassociated metabolic parameters[J]. PLo S One,2015,10:e0126931.
[28]Cani PD,Bibiloni R,Knauf C,et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice[J].Diabetes,2008,57:1470-81.
[29]Cani P D. Human gut microbiome:Hopes,threats and promises[J].Gut,2018,67(9):1716-1725.
[30]Ravussin Y,Koren O,Spor A,et al. Responses of gut microbiota to diet composition and weight loss in lean and obese mice[J].Obesity,2012,20:738-747.
[31]Devkota S,Wang Y,Musch M W,et al.Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/-mice[J].Nature,2012,487:104-108.
[32]Xiao L,Si B S,Feng Q,et al.High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice[J].Microbiome,2017,5(1):43.
[33]Buffie C G,Bucci V,Stein R R,et al.Precision microbiome restoration of bile acid-mediated resistance to Clostridium difficile[J].Nature,2015,517(7533):205-208.
[34]Koeth R A,Wang Z,Levison B S,et al.Intestinal microbiota metabolism of L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nature Medicine,2013,19(5):576-585.
[35]张芹，周中凯，任晓冲.高通量测序技术研究高糖饮食对小鼠肠道菌群的影响[J].食品安全质量检测学报，2015(5):1776-1782.
[36]Kumar P,Prajapati B,Mishra P K,et al. Influence of gut microbiota on inflammation and pathogenesis of sugar rich diet induced diabetes[J]. Immunome Research,2016,12(1):109-119.
[37]王芳.广西巴马长寿老人肠道菌群及其与膳食纤维多糖饮食关联性研究[D].南宁:广西大学，2015.
[38]So D,Whelan K,Rossi M,et al.Dietary fiber intervention on gut microbiota composition in healthy adults:A systematic review and meta-analysis[J]. The American Journal of Clinical Nutrition,2018,107(6):965-983.
[39]Kassem Makki,Deehan Edward C,Jens Walter,et al. The impact of dietary fiber on gut microbiota in host health and disease[J].Cell Host&Microbe,2018,23(6):705-715.
[40]Sonnenburg E D,Smits S A,Tikhonov M,et al.Diet-induced extinctions in the gut microbiota compound over generations[J].Nature,2016,529:212-215.
[41]Ara Koh,Filipe De Vadder,Petia Kovatcheva-Datchary,et al.From dietary fiber to host physiology:Short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.
[42]Chen D,Yang Z,Chen X,et al. Effect of Lactobacillus rhamnosus hsryfm 1301 on the gut microbiota and lipid metabolism in rats fed a high-fat diet[J].Journal of Microbiology and Biotechnology,2015,25:687-95.
[43]Liang Y,Lin C,Zhang Y,et al. Probiotic mixture of Lactobacillus and Bifidobacterium alleviates systemic adiposity and inflammation in non-alcoholic fatty liver disease rats through Gpr109a and the commensal metabolite butyrate[J].Inflammopharmacology,2018,26(4):1051-1055.
[44]Stenman L K,Waget A,Garret C,et al. Potential probiotic Bifidobacterium animals ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice[J]. Beneficial Microbes,2014,5(4):437-445.
[45]Zhao Liping,Zhang Feng,Ding Xiaoying,et al.Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J]. Science,2018,359(6380):1151-1156.
[46]Valdes A M,Walter J,Segal E,et al. Role of the gut microbiota in nutrition and health[J]. Bmj Clinical Research,2018,361:k2179.
[47]Marco C,Elena B,Matteo S,et al. et al. Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet[J]. British Journal of Nutrition,2016,116(1):1-14.
[48]Trompette A,Gollwitzer E S,Yadava K A,et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis[J]. Nature Medicine,2014,20(2):159-166.
[2] Sabes-Figuera R,Knapp M,Bendeck M,et al. The composition of the gut microbiota throughout life,with an emphasis on early life[J].Microbial Ecology in Health&Disease,2015,26(1):26050.
[3]Singh R K,Chang H W,Yan D,et al.Influence of diet on the gut microbiome and implications for human health[J]. Journal of Translational Medicine,2017,15(1):73.
[4]Van Hylckama,Vlieg J E,Veiga P,et al.Impact of microbial transformation of food on health-from fermented foods to fermentation in the gastro-intestinal tract[J]. Current Opinion in Biotechnology,2011,22(2):211-219.
[5]Schroeder B O,Bckhed F.Signals from the gut microbiota to distant organs in physiology and disease[J]. Nature Medicine,2016,22(10):1079.
[6]Mélanie Deschasaux,Bouter K E,Andrei Prodan,et al.Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography[J]. Nature Medicine,2018,24(10):1526.
[7]Schnorr S L,Candela M,Rampelli S,et al.Gut microbiome of the Hadza hunter-gatherers[J]. Nature Communications,2014,5:3654.
[8]De Filippo C,Cavalieri D,Di Paola M,et al.Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa[J]. Proceddings of the National Academy of Science of the USA,2010,107(33):14691-14696.
[9]Harrison Christy A,Taren Douglas.How poverty affects diet to shape the microbiota and chronic disease[J]. Nature Reviews Immunology,2018,18(4):279.
[10]Bocci V.The neglected organ:Bacterial flora has a crucial immunostimulatory role[J].Perspectives in Biology and Medicine,1992,35(2):251.
[11]孙长豹，刘志静，刘飞，等.食物成分对肠道菌群结构的影响[J].食品研究与开发，2018,39(9):178-182.
[12]Arumugam M,Raes J,Pelleter E,et al. Enterotypes of the human gut microbiome[J].Nature,2011,473:174-180.
[13]Gill S R,Pop M,Deboy R T,et al.Metagenomic analysis of the human distal gut microbiome[J]. Science,2006,312:1355-1359.
[14]Sina C,Gavrilova O,Forster M,et al. G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation[J]. The Journal of Immunology,2009,183(11):7514-7522.
[15]Carbonero F,Benefiel A C,Gaskins H R.Contributions of the microbial hydrogen economy to colonic homeostasis[J]. Nature,2012,9(9):504-518.
[16]Scott K P,Gratz S W,Sheridan P O,et al.The influence of diet on the gut microbiota[J].Pharmacological Research,2013,69(1):52-60.
[17]Li H,Li T,Beasley D A E,et al.Diet Diversity is associated with beta but not alpha diversity of pika gut microbiota[J].Frontiers in Microbiology,2016,7:1169.
[18]Filippo C D,Cavalieri D,Paola M D,et al.Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa[J]. Proceedings of the National Academy of Sciences of the United States of America,2010,107(33):14691-14696.
[19]Russell W R,Gratz S W,Duncan S H,et al.High-protein,reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health[J]. American Journal of Clinical Nutrition,2011,93(5):1062.
[20]Wang L,Jacobs J P,Lagishetty V,et al.High-protein diet promotes sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats[J]. American Journal of Physiology Regulatory Integrative and Comparative Physiology,2017,313(4):R473-R486.
[21]S'witecka D,Dominika S',Narbad A,et al.The study on the impact of glycated pea proteins on human intestinal bacteria[J].International Journal of Food Microbiology,2011,145(1):267-272.
[22]Chang H K,Park J,Kim M.Gut microbiota-derived shortchain fatty acids,T cells,and inflammation[J].Immune Network,2014,14(6):277.
[23]Levine M E,Suarez J A,Brandhorst S,et al. Low protein intake is associated with a major reduction in IGF-1,cancer,and overall mortality in the 65 and younger but not older population[J].Cell Metabolism,2014,19(3):407-417.
[24]Hamilton M Kristina,Boudry Galle,Lemay Danielle G.Changes in intestinal barrier function and gut microbiota in highfat diet-fed rats are dynamic and region dependent[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2015,308(10):G840-G851.
[25]Natividad J M,Lamas B,Hang P P,et al. Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice[J]. Nature Communications,2018,9(1):2802.
[26]Lin H,An Y,Hao F,et al.Correlations of fecal metabonomic and microbiomic changes induced by high-fat diet in the preobesity state[J].Scientific Reports,2016,6:21618.
[27]Lecomte V,Kaakoush NO,Maloney CA,et al.Changes in gut microbiota in rats fed a high fat diet correlate with obesityassociated metabolic parameters[J]. PLo S One,2015,10:e0126931.
[28]Cani PD,Bibiloni R,Knauf C,et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice[J].Diabetes,2008,57:1470-81.
[29]Cani P D. Human gut microbiome:Hopes,threats and promises[J].Gut,2018,67(9):1716-1725.
[30]Ravussin Y,Koren O,Spor A,et al. Responses of gut microbiota to diet composition and weight loss in lean and obese mice[J].Obesity,2012,20:738-747.
[31]Devkota S,Wang Y,Musch M W,et al.Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/-mice[J].Nature,2012,487:104-108.
[32]Xiao L,Si B S,Feng Q,et al.High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice[J].Microbiome,2017,5(1):43.
[33]Buffie C G,Bucci V,Stein R R,et al.Precision microbiome restoration of bile acid-mediated resistance to Clostridium difficile[J].Nature,2015,517(7533):205-208.
[34]Koeth R A,Wang Z,Levison B S,et al.Intestinal microbiota metabolism of L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nature Medicine,2013,19(5):576-585.
[35]张芹，周中凯，任晓冲.高通量测序技术研究高糖饮食对小鼠肠道菌群的影响[J].食品安全质量检测学报，2015(5):1776-1782.
[36]Kumar P,Prajapati B,Mishra P K,et al. Influence of gut microbiota on inflammation and pathogenesis of sugar rich diet induced diabetes[J]. Immunome Research,2016,12(1):109-119.
[37]王芳.广西巴马长寿老人肠道菌群及其与膳食纤维多糖饮食关联性研究[D].南宁:广西大学，2015.
[38]So D,Whelan K,Rossi M,et al.Dietary fiber intervention on gut microbiota composition in healthy adults:A systematic review and meta-analysis[J]. The American Journal of Clinical Nutrition,2018,107(6):965-983.
[39]Kassem Makki,Deehan Edward C,Jens Walter,et al. The impact of dietary fiber on gut microbiota in host health and disease[J].Cell Host&Microbe,2018,23(6):705-715.
[40]Sonnenburg E D,Smits S A,Tikhonov M,et al.Diet-induced extinctions in the gut microbiota compound over generations[J].Nature,2016,529:212-215.
[41]Ara Koh,Filipe De Vadder,Petia Kovatcheva-Datchary,et al.From dietary fiber to host physiology:Short-chain fatty acids as key bacterial metabolites[J].Cell,2016,165(6):1332-1345.
[42]Chen D,Yang Z,Chen X,et al. Effect of Lactobacillus rhamnosus hsryfm 1301 on the gut microbiota and lipid metabolism in rats fed a high-fat diet[J].Journal of Microbiology and Biotechnology,2015,25:687-95.
[43]Liang Y,Lin C,Zhang Y,et al. Probiotic mixture of Lactobacillus and Bifidobacterium alleviates systemic adiposity and inflammation in non-alcoholic fatty liver disease rats through Gpr109a and the commensal metabolite butyrate[J].Inflammopharmacology,2018,26(4):1051-1055.
[44]Stenman L K,Waget A,Garret C,et al. Potential probiotic Bifidobacterium animals ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice[J]. Beneficial Microbes,2014,5(4):437-445.
[45]Zhao Liping,Zhang Feng,Ding Xiaoying,et al.Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J]. Science,2018,359(6380):1151-1156.
[46]Valdes A M,Walter J,Segal E,et al. Role of the gut microbiota in nutrition and health[J]. Bmj Clinical Research,2018,361:k2179.
[47]Marco C,Elena B,Matteo S,et al. et al. Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet[J]. British Journal of Nutrition,2016,116(1):1-14.
[48]Trompette A,Gollwitzer E S,Yadava K A,et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis[J]. Nature Medicine,2014,20(2):159-166.